AR028576A1 - Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa - Google Patents

Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa

Info

Publication number: AR028576A1
Authority: AR; Argentina
Prior art keywords: phosphodesterase; inhibitors; useful; carboline derivatives; carboline
Prior art date: 2000-05-17

Application number

ARP010102326A

Other languages

English (en)

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2001-05-16

Publication date

2003-05-14

2001-05-16 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-05-14 Publication of AR028576A1 publication Critical patent/AR028576A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ARP010102326A 2000-05-17 2001-05-16 Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa AR028576A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20466700P	2000-05-17	2000-05-17
US09/847,767 US6492358B2 (en)	2000-05-17	2001-05-02	β-carboline derivatives useful as inhibitors of phosphodiesterase

Publications (1)

Publication Number	Publication Date
AR028576A1 true AR028576A1 (es)	2003-05-14

Family

ID=22758909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP010102326A AR028576A1 (es)	2000-05-17	2001-05-16	Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa

Country Status (32)

Country	Link
US (2)	US6492358B2 (es)
EP (1)	EP1289985B1 (es)
JP (1)	JP5014551B2 (es)
KR (1)	KR20030031482A (es)
CN (1)	CN1255403C (es)
AR (1)	AR028576A1 (es)
AT (1)	ATE256127T1 (es)
AU (2)	AU2001261167B2 (es)
BG (1)	BG66141B1 (es)
CA (1)	CA2409715C (es)
CZ (1)	CZ20023934A3 (es)
DE (1)	DE60101479T2 (es)
DK (1)	DK1289985T3 (es)
ES (1)	ES2211806T3 (es)
GE (1)	GEP20053511B (es)
HK (1)	HK1051368A1 (es)
HR (1)	HRP20020910B1 (es)
HU (1)	HUP0302412A3 (es)
IL (2)	IL152873A0 (es)
MX (1)	MXPA02011426A (es)
MY (1)	MY128479A (es)
NO (1)	NO324251B1 (es)
NZ (1)	NZ522731A (es)
PL (1)	PL205507B1 (es)
PT (1)	PT1289985E (es)
RU (1)	RU2271358C2 (es)
SK (1)	SK16972002A3 (es)
TR (1)	TR200302309T4 (es)
TW (1)	TWI286553B (es)
UA (1)	UA74826C2 (es)
WO (1)	WO2001087038A2 (es)
ZA (1)	ZA200210111B (es)

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US6987115B2 (en) *	2000-12-08	2006-01-17	Smithkline Beecham Corporation	Antibacterial compounds
US6900220B2 (en) *	2001-01-02	2005-05-31	Syntex (U.S.A.) Llc	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
JP4220779B2 (ja) *	2001-02-12	2009-02-04	リリーアイコスリミテッドライアビリティカンパニー	化学化合物
DE60216233T2 (de) *	2001-02-12	2007-09-27	Lilly Icos Llc, Wilmington	Carbolinderivate
CA2441792C (en) *	2001-04-25	2010-08-03	Lilly Icos Llc	Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction
MXPA03011081A (es) *	2001-06-05	2004-07-08	Lilly Icos Llc	Derivados de carbolina como inhibidores de pde5.
EP1397361B1 (en)	2001-06-21	2006-08-09	Lilly Icos LLC	Carboline derivatives as pdev inhibitors
CA2467269C (en)	2001-11-14	2011-04-05	Weiqin Jiang	Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
KR20100112659A (ko) *	2002-02-07	2010-10-19	지티엑스, 인코포레이티드	선택적 안드로겐 수용체 조절자를 이용한 양성 전립선 과형성증의 치료 방법
ES2297217T3 (es) *	2002-06-19	2008-05-01	Janssen Pharmaceutica Nv	Derivados sustituidos de 2,4-dihidro-pirrolo(3,4-b)quinolin-9-ona utilizados como inhibidores de fosfodiesterasa.
WO2004113300A1 (ja) *	2003-06-23	2004-12-29	Ono Pharmaceutical Co., Ltd.	新規三環性複素環化合物
WO2005070930A2 (en)	2004-01-23	2005-08-04	Chiron Corporation	Tetrahydrocarboline compounds as anticancer agents
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
CN102408425A (zh)	2004-03-15	2012-04-11	Ptc医疗公司	用于抑制血管生成的咔啉衍生物及其应用
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
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JP2009502961A (ja) *	2005-07-29	2009-01-29	コンサートファーマシューティカルズインコーポレイテッド	新規な医薬組成物
US7678363B2 (en)	2005-08-26	2010-03-16	Braincells Inc	Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
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AU2007249435A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 HT receptor mediated neurogenesis
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US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
EP2178537A4 (en) *	2007-07-19	2011-08-17	Merck Sharp & Dohme	BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS
JP2011505373A (ja)	2007-11-30	2011-02-24	ビオタサイエンティフィックマネージメントピーティーワイリミテッド	抗菌剤としての２環式ｐｐａｔ阻害剤
BRPI0907122B8 (pt)	2008-01-11	2021-05-25	Albany Molecular Res Inc	compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
US8338447B2 (en)	2008-03-24	2012-12-25	Medivation Technologies, Inc.	Pyrido[3,4-B]indoles and methods of use
MD4009C2 (ro) *	2008-07-15	2010-08-31	Институт Химии Академии Наук Молдовы	Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
WO2010107485A1 (en) *	2009-03-17	2010-09-23	The Trustees Of Columbia University In The City Of New York	E3 ligase inhibitors
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja)	2009-07-01	2012-12-13	アルバニーモレキュラーリサーチ，インコーポレイテッド	アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
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WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
ES2587856T3 (es)	2011-03-18	2016-10-27	Ono Pharmaceutical Co., Ltd.	Derivado de tetrahidrocarbolina
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
US10092574B2 (en)	2012-09-26	2018-10-09	Valorisation-Recherche, Limited Partnership	Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
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2001
- 2001-03-05 UA UA2002119179A patent/UA74826C2/uk unknown
- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
- 2001-05-03 EP EP01935038A patent/EP1289985B1/en not_active Expired - Lifetime
- 2001-05-03 CA CA2409715A patent/CA2409715C/en not_active Expired - Fee Related
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-03 AU AU2001261167A patent/AU2001261167B2/en not_active Ceased
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/en active IP Right Grant
- 2001-05-03 IL IL15287301A patent/IL152873A0/xx unknown
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Application Discontinuation
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 CZ CZ20023934A patent/CZ20023934A3/cs unknown
- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
- 2001-05-16 MY MYPI20012323A patent/MY128479A/en unknown
- 2001-05-16 AR ARP010102326A patent/AR028576A1/es unknown
2002
- 2002-01-21 TW TW091100842A patent/TWI286553B/zh not_active IP Right Cessation
- 2002-10-01 US US10/261,861 patent/US6864253B2/en not_active Expired - Lifetime
- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-15 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown
2003
- 2003-05-22 HK HK03103637A patent/HK1051368A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
MY128479A (en)	2007-02-28
US6864253B2 (en)	2005-03-08
KR20030031482A (ko)	2003-04-21
UA74826C2 (en)	2006-02-15
HUP0302412A2 (hu)	2003-11-28
DK1289985T3 (da)	2004-04-05
NZ522731A (en)	2004-09-24
HK1051368A1 (en)	2003-08-01
CN1255403C (zh)	2006-05-10
US20030166641A1 (en)	2003-09-04
HRP20020910B1 (en)	2011-02-28
SK16972002A3 (sk)	2003-11-04
RU2271358C2 (ru)	2006-03-10
EP1289985A2 (en)	2003-03-12
TR200302309T4 (tr)	2004-02-23
DE60101479D1 (en)	2004-01-22
US20020010189A1 (en)	2002-01-24
CA2409715A1 (en)	2001-11-22
WO2001087038A3 (en)	2002-05-16
NO20025527D0 (no)	2002-11-18
NO20025527L (no)	2003-01-16
IL152873A0 (en)	2003-06-24
CN1446217A (zh)	2003-10-01
PL365445A1 (en)	2005-01-10
AU2001261167B2 (en)	2006-10-05
JP2003533453A (ja)	2003-11-11
ES2211806T3 (es)	2004-07-16
HUP0302412A3 (en)	2007-02-28
PL205507B1 (pl)	2010-04-30
BG66141B1 (bg)	2011-07-29
DE60101479T2 (de)	2005-04-28
HRP20020910A2 (en)	2004-12-31
PT1289985E (pt)	2004-03-31
TWI286553B (en)	2007-09-11
MXPA02011426A (es)	2004-09-06
GEP20053511B (en)	2005-05-10
NO324251B1 (no)	2007-09-17
CZ20023934A3 (cs)	2003-10-15
ATE256127T1 (de)	2003-12-15
BG107285A (bg)	2003-07-31
AU6116701A (en)	2001-11-26
WO2001087038A2 (en)	2001-11-22
IL152873A (en)	2012-01-31
ZA200210111B (en)	2004-03-12
US6492358B2 (en)	2002-12-10
JP5014551B2 (ja)	2012-08-29
EP1289985B1 (en)	2003-12-10
CA2409715C (en)	2010-09-14

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