[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PT1261322E - Composições farmacêuticas compreendendo um agonista ou antagonista do receptor de adenosina - Google Patents

Composições farmacêuticas compreendendo um agonista ou antagonista do receptor de adenosina Download PDF

Info

Publication number
PT1261322E
PT1261322E PT00956773T PT00956773T PT1261322E PT 1261322 E PT1261322 E PT 1261322E PT 00956773 T PT00956773 T PT 00956773T PT 00956773 T PT00956773 T PT 00956773T PT 1261322 E PT1261322 E PT 1261322E
Authority
PT
Portugal
Prior art keywords
antagonist
pharmaceutical compositions
receptor agonist
adenosine receptor
adenosine
Prior art date
Application number
PT00956773T
Other languages
English (en)
Inventor
Pnina Fishman
Original Assignee
Can Fite Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13186499A external-priority patent/IL131864A0/xx
Application filed by Can Fite Biopharma Ltd filed Critical Can Fite Biopharma Ltd
Publication of PT1261322E publication Critical patent/PT1261322E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT00956773T 1999-09-10 2000-09-08 Composições farmacêuticas compreendendo um agonista ou antagonista do receptor de adenosina PT1261322E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13186499A IL131864A0 (en) 1999-09-10 1999-09-10 Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
IL13368099A IL133680A0 (en) 1999-09-10 1999-12-23 Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist

Publications (1)

Publication Number Publication Date
PT1261322E true PT1261322E (pt) 2008-01-09

Family

ID=26323880

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00956773T PT1261322E (pt) 1999-09-10 2000-09-08 Composições farmacêuticas compreendendo um agonista ou antagonista do receptor de adenosina

Country Status (19)

Country Link
US (2) US7064112B1 (pt)
EP (1) EP1261322B1 (pt)
JP (2) JP4980530B2 (pt)
KR (2) KR100584797B1 (pt)
CN (1) CN100358512C (pt)
AU (1) AU782826B2 (pt)
BR (1) BR0013905A (pt)
CA (1) CA2384111C (pt)
DE (1) DE60037277T2 (pt)
DK (1) DK1261322T3 (pt)
ES (1) ES2296637T3 (pt)
HK (1) HK1052653B (pt)
HU (1) HU226913B1 (pt)
IL (1) IL133680A0 (pt)
MX (1) MXPA02002546A (pt)
PL (1) PL199852B1 (pt)
PT (1) PT1261322E (pt)
RU (1) RU2239455C2 (pt)
WO (1) WO2001019360A2 (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121272A (en) * 1997-07-10 2000-06-01 Can Fite Technologies Ltd Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia
HUP0301315A3 (en) * 2000-06-21 2007-10-29 Hoffmann La Roche Benzothiazole derivatives, process for their preparation, their use and pharmaceutical compositions containing them
DE60203702T2 (de) 2001-01-16 2006-03-02 Can-Fite Biopharma Ltd. Verwendung eines adenosin-a3-rezeptor-agonisten zur hemmung der virenreplikation
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
US20040204481A1 (en) * 2001-04-12 2004-10-14 Pnina Fishman Activation of natural killer cells by adenosine A3 receptor agonists
US7049303B2 (en) 2001-11-07 2006-05-23 Medical Research Council Inhibition of viruses
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
DE60315863T2 (de) * 2002-10-22 2008-05-15 Can-Fite Biopharma Ltd. A3ar als ein marker für einen erkrankungszustand
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
EA011279B1 (ru) 2004-05-24 2009-02-27 Ф. Хоффманн-Ля Рош Аг (4-метокси-7-морфолин-4-илбензотиазол-2-ил)-амид 4-гидрокси-4-метилпиперидин-1-карбоновой кислоты
BRPI0510406A (pt) 2004-05-26 2007-12-26 Inotek Pharmaceuticals Corp derivados de purina como agonistas do receptor de adenosina a1 e métodos de uso destes
US7825102B2 (en) 2004-07-28 2010-11-02 Can-Fite Biopharma Ltd. Treatment of dry eye conditions
US7863253B2 (en) 2004-09-20 2011-01-04 Inotek Pharmaceuticals Corporation Purine Derivatives and methods of use thereof
DE602005008095D1 (de) 2004-11-05 2008-08-21 Hoffmann La Roche Verfahren zur herstellung von isonikotinsäurederivaten
JP2008519029A (ja) * 2004-11-08 2008-06-05 キャン−ファイト・バイオファーマ・リミテッド 加速骨吸収の治療的処置
CA2586420A1 (en) * 2004-11-22 2007-04-12 King Pharmaceuticals Research & Development, Inc. Enhancing treatment of cancer and hif-1 mediated disoders with adenosine a3 receptor antagonists
JP4801724B2 (ja) 2005-03-23 2011-10-26 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのアセチレニル−ピラゾロ−ピリミジン誘導体
CN101273040B (zh) 2005-09-27 2011-11-09 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的*二唑基吡唑并嘧啶类化合物
CA2627319A1 (en) 2005-11-30 2007-06-07 Prakash Jagtap Purine derivatives and methods of use thereof
EP1976494A1 (en) * 2006-01-27 2008-10-08 Can-Fite Biopharma Ltd. Adenosine a3 receptor agonists for the treatment of dry eye disorders
WO2008023362A2 (en) * 2006-08-21 2008-02-28 Can-Fite Biopharma Ltd. Use of a combination of methotrexate and an a3ar agonist for the treatment of cancer
CA2665616A1 (en) * 2006-10-06 2008-04-17 The Trustees Of The University Of Pennsylvania Effective delivery of cross-species a3 adenosine-receptor antagonists toreduce intraocular pressure
GB0625100D0 (en) * 2006-12-15 2007-01-24 Univ Murcia Epigallocatechin-3-gallate compositions for cancer therapy and chemoprotection
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
TW200914048A (en) * 2007-07-17 2009-04-01 Combinatorx Inc Combinations for the treatment of B-cell proliferative disorders
TW200920381A (en) * 2007-07-17 2009-05-16 Combinatorx Inc Treatments of B-cell proliferative disorders
WO2009151569A2 (en) * 2008-06-09 2009-12-17 Combinatorx, Incorporated Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders
US8629275B2 (en) 2008-09-08 2014-01-14 Merck Sharp & Dohme Corp. AHCY hydrolase inhibitors for treatment of hyper homocysteinemia
AU2010250759B2 (en) 2009-05-17 2013-03-14 Can-Fite Biopharma Ltd. A3 adenosine receptor agonists for the reduction of intraocular pressure
US9199102B2 (en) 2009-07-21 2015-12-01 Oradin Pharmaceutical Ltd. A3 adenosine receptor ligands for modulation of pigmentation
WO2011074903A2 (ko) * 2009-12-17 2011-06-23 이화여자대학교 산학협력단 Ａ3 아데노신 수용체 효능제를 포함하는 약제학적 조성물
PT2523669T (pt) 2010-01-11 2017-01-31 Inotek Pharmaceuticals Corp Associação, conjunto ( kit ) e método de redução da pressão intraocular
JP2013521274A (ja) 2010-03-03 2013-06-10 ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ・アズ リプレゼンテッド バイ ザ セクレタリー・デパートメント オブ ヘルス アンド ヒューマン サービシーズ ブドウ膜炎の治療のためのａ３ａｒアゴニスト
US8476247B2 (en) 2010-03-26 2013-07-02 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
US20130109645A1 (en) 2010-03-31 2013-05-02 The united States of America,as represented by Secretary,Dept.,of Health and Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
GEP20166496B (en) 2011-12-22 2016-06-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
JP2015504088A (ja) * 2012-01-23 2015-02-05 キャン−ファイト バイオファーマ リミテッドＣａｎ−Ｆｉｔｅ ＢｉｏＰｈａｒｍａ Ｌｔｄ． 肝疾患の治療
RS56150B1 (sr) 2012-01-26 2017-11-30 Inotek Pharmaceuticals Corp Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US8822460B2 (en) 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
JP6204983B2 (ja) 2012-07-19 2017-09-27 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２のオクタヒドロ−シクロペンタピロリル拮抗薬
US9549943B2 (en) 2012-08-09 2017-01-24 Can-Fite Biopharma Ltd. A3 adenosine receptor ligands for use in treatment of a sexual dysfunction
EP2968389A4 (en) 2013-03-15 2016-08-24 Inotek Pharmaceuticals Corp OPHTHALMIC FORMULATIONS
IL242723B (en) 2015-11-23 2019-12-31 Can Fite Biopharma Ltd A3 adenosine receptor ligand for the treatment of ectopic fat accumulation
EP3445368B1 (en) 2016-04-21 2024-07-17 Astrocyte Pharmaceuticals, Inc. Compounds and methods for treating neurological and cardiovascular conditions
IL254535A0 (en) 2017-09-17 2017-11-30 Can Fite Biopharma Ltd Adenosine a3 receptor ligand for use in the management of cytokine release syndrome
JP7311855B2 (ja) 2018-02-09 2023-07-20 アストロサイト ファーマシューティカルズ， インコーポレイテッド 嗜癖および関連する障害を処置するための化合物および方法
WO2020069068A1 (en) 2018-09-26 2020-04-02 Astrocyte Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
IL264112A (en) 2019-01-06 2020-07-30 Fishman Pnina Adenosine a3 receptor ligand for use in lowering adipocyte levels

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5688774A (en) 1993-07-13 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
ATE206432T1 (de) 1993-07-13 2001-10-15 Nasa A3 -adenosin -rezeptor agonisten
GB2289218A (en) * 1994-05-06 1995-11-15 Merck & Co Inc Inhibition of TNFalpha production with agonists of the A2b subtype of the adenosine receptor
RU2071770C1 (ru) 1994-12-14 1997-01-20 Владислав Алексеевич Шматко Способ лечения рака шейки матки и яичников
RU2071771C1 (ru) 1995-01-11 1997-01-20 Владислав Алексеевич Шматко Способ лечения рака молочной железы
AU750322B2 (en) 1997-05-09 2002-07-18 Trustees Of The University Of Pennsylvania, The Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
IL121272A (en) 1997-07-10 2000-06-01 Can Fite Technologies Ltd Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia
US6048865A (en) 1997-07-29 2000-04-11 Medco Research, Inc. N6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator
CA2296485A1 (en) 1997-07-29 1999-02-11 Medco Research, Inc. N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators
AU1363699A (en) * 1997-10-23 1999-05-10 National Institute Of Health Methods for reducing ischemic injury of the heart via the sequential administ ration of monophosphoryl lipid a and adenosine receptor agents
WO1999063938A2 (en) 1998-06-08 1999-12-16 Epigenesis Pharmaceuticals, Inc. Composition and method for prevention and treatment of cardiopulmonary and renal failure or damage associated with ischemia, endotoxin release, ards or brought about by administration of certain drugs
US6448253B1 (en) 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
IL127947A0 (en) 1999-01-07 1999-11-30 Can Fite Technologies Ltd Pharmaceutical use of adenosine agonists
PT1150991E (pt) * 1999-02-01 2004-08-31 Univ Virginia Composicoes para o tratamento da resposta inflamatoria
IL131096A (en) 1999-07-26 2004-09-27 Can Fite Technologies Ltd Method for preparing a composition derived from muscle tissue

Also Published As

Publication number Publication date
JP2003514771A (ja) 2003-04-22
CA2384111A1 (en) 2001-03-22
HK1052653A1 (en) 2003-09-26
RU2002109228A (ru) 2004-01-10
DE60037277T2 (de) 2008-10-09
AU6863400A (en) 2001-04-17
DE60037277D1 (de) 2008-01-10
BR0013905A (pt) 2003-07-15
CA2384111C (en) 2008-05-27
JP2007204496A (ja) 2007-08-16
US20060084626A1 (en) 2006-04-20
CN100358512C (zh) 2008-01-02
HU226913B1 (en) 2010-03-01
ES2296637T3 (es) 2008-05-01
HUP0203870A2 (hu) 2003-03-28
CN1391468A (zh) 2003-01-15
KR100674529B1 (ko) 2007-01-30
EP1261322B1 (en) 2007-11-28
KR20020038749A (ko) 2002-05-23
WO2001019360A2 (en) 2001-03-22
RU2239455C2 (ru) 2004-11-10
JP4980530B2 (ja) 2012-07-18
KR100584797B1 (ko) 2006-06-02
MXPA02002546A (es) 2003-07-21
EP1261322A2 (en) 2002-12-04
KR20060036490A (ko) 2006-04-28
HUP0203870A3 (en) 2005-07-28
PL199852B1 (pl) 2008-11-28
AU782826B2 (en) 2005-09-01
WO2001019360A3 (en) 2002-09-19
IL133680A0 (en) 2001-04-30
US7064112B1 (en) 2006-06-20
PL356469A1 (en) 2004-06-28
HK1052653B (zh) 2008-08-01
DK1261322T3 (da) 2008-04-07

Similar Documents

Publication Publication Date Title
HK1052653A1 (en) Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
HUP0203638A3 (en) Betha2-adrenergic receptor agonists and pharmaceutical compositions containing them and their use
HUP0201545A3 (en) Betha2-adrenergic receptor agonists and pharmaceutical compositions containing them
AU1845402A (en) Nmda receptor agonist pharmaceutical compositions
HUP0401437A3 (en) Adenosine a3 receptor agonists
PT1192169E (pt) C-pirazoles agonistas do receptor a2a
IS5706A (is) Adenosín A3 viðtakastillar
EP1187614A4 (en) SUBSTITUTED PIPERIDINES THAN MELANOCORTIN-4 RECEPTOR AGONISTS
IL142958A0 (en) Vitronectin receptor antagonist pharmaceuticals
EG24194A (en) 5ht-a-partial agonist pharmaceutical compositions
PL356990A1 (en) Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
IL160715A0 (en) Pharmaceutical compositions containing an a1 adenosine receptor antagonist
HUP0201300A3 (en) Il-8 receptor antagonist imidazoidinylidene-2-imino derivatives and pharmaceutical compositions containing them
EG24025A (en) Vitronectin receptor antagonist
HUP0203603A3 (en) Novel il-8 receptor antagonist indole derivatives and pharmaceutical compositions containing them
AU4980999A (en) A3 adenosine receptor antagonists
AU5861900A (en) Receptor agonists and antagonists
HUP0200057A2 (en) Dopamine d1 receptor agonist compounds, pharmaceutical compositions containing them and their use
IL131864A0 (en) Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
IL160438A0 (en) Pharmaceutical compositions containing an angiotensin ii receptor antagonist
SI1347760T1 (en) Nmda receptor agonist pharmaceutical compositions
IL165716A0 (en) Pharmaceutical compositions containing heterocyclic adenosine receptor antagonists
HU0800727D0 (hu) Opioid agonista és antagonista hatóanyagot tartalmazó gyógyszerkészítmény
GB0015901D0 (en) Compositions containing 5ht receptor agonists
AU2512800A (en) Alpha1-adrenergic receptor antagonists