PT1088824E - Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilase - Google Patents
Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilaseInfo
- Publication number
- PT1088824E PT1088824E PT00308131T PT00308131T PT1088824E PT 1088824 E PT1088824 E PT 1088824E PT 00308131 T PT00308131 T PT 00308131T PT 00308131 T PT00308131 T PT 00308131T PT 1088824 E PT1088824 E PT 1088824E
- Authority
- PT
- Portugal
- Prior art keywords
- blycylic
- glycogene
- pyrrolyl
- amides
- phosphorylase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15714899P | 1999-09-30 | 1999-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1088824E true PT1088824E (pt) | 2004-04-30 |
Family
ID=22562529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00308131T PT1088824E (pt) | 1999-09-30 | 2000-09-18 | Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilase |
Country Status (10)
Country | Link |
---|---|
US (3) | US6399601B1 (pt) |
EP (1) | EP1088824B1 (pt) |
JP (1) | JP3489819B2 (pt) |
AT (1) | ATE257480T1 (pt) |
BR (1) | BR0004582A (pt) |
CA (1) | CA2321379A1 (pt) |
DE (1) | DE60007592T2 (pt) |
DK (1) | DK1088824T3 (pt) |
ES (1) | ES2211454T3 (pt) |
PT (1) | PT1088824E (pt) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223725B1 (en) * | 1997-11-14 | 2007-05-29 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
ATE381939T1 (de) | 1997-11-14 | 2008-01-15 | Amylin Pharmaceuticals Inc | Neuartige exendin agonisten |
WO2001026659A1 (de) * | 1999-10-12 | 2001-04-19 | Lareida Juerg | Arzneimittel zur behandlung von neuropathien |
CO5271699A1 (es) * | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa |
KR100873585B1 (ko) * | 2000-03-17 | 2008-12-11 | 아지노모토 가부시키가이샤 | 당뇨병성 합병증용 약제 |
EP1136071A3 (en) * | 2000-03-22 | 2003-03-26 | Pfizer Products Inc. | Use of glycogen phosphorylase inhibitors |
KR20030023747A (ko) * | 2000-08-11 | 2003-03-19 | 화이자 인코포레이티드 | 인슐린 저항성 증후군의 치료 |
US20020165237A1 (en) * | 2000-08-11 | 2002-11-07 | Fryburg David Albert | Treatment of the insulin resistance syndrome |
GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
ES2347137T3 (es) * | 2000-10-20 | 2010-10-26 | Amylin Pharmaceuticals, Inc. | Tratamiento de miocardio hibernante y cardiomiopatia diabetica con un peptido gpl-1. |
BR0206847A (pt) * | 2001-02-02 | 2004-02-25 | Pfizer | Tratamento do diabete melito |
EP1419771A4 (en) * | 2001-08-23 | 2004-11-03 | Mitsubishi Pharma Corp | PROPHYLACTIC AND / OR CURATIVE AGENT FOR DISEASES INDUCED BY ARTERIOSCLEROSIS ACTIVITY |
CA2465382A1 (en) * | 2001-10-29 | 2003-05-08 | Japan Tobacco Inc. | Indole compound and medicinal use thereof |
ES2280596T3 (es) * | 2001-12-29 | 2007-09-16 | Novo Nordisk A/S | Uso combinado de un compuesto de glp-1 y un inhibidor de una aldosa reductasa. |
GB0205165D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205170D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
WO2003091213A1 (fr) * | 2002-04-25 | 2003-11-06 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'amide ou sels de ces derives |
US7057046B2 (en) | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
US20040038864A1 (en) * | 2002-06-27 | 2004-02-26 | Per Balschmidt | Use of dimethyl sulfone as isotonicity agent |
DK1543011T3 (da) | 2002-09-06 | 2006-08-07 | Janssen Pharmaceutica Nv | Thienopyrrolyl- og furanopyrrolylforbindelser og deres anvendelse som histamin H4-receptorligander |
GB0222912D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
GB0222909D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
BR0316099A (pt) | 2002-11-07 | 2005-09-27 | Pfizer Prod Inc | Agentes antidiabéticos |
JP4552189B2 (ja) * | 2002-11-14 | 2010-09-29 | 小野薬品工業株式会社 | 脊柱管狭窄症治療剤 |
US7098235B2 (en) | 2002-11-14 | 2006-08-29 | Bristol-Myers Squibb Co. | Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds |
EP1569682A2 (en) * | 2002-12-03 | 2005-09-07 | Novo Nordisk A/S | Combination treatment using exendin-4 and thiazolidinediones |
EP1594439A2 (en) * | 2003-02-13 | 2005-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS |
EP1615899A1 (en) * | 2003-04-15 | 2006-01-18 | Pfizer Inc. | Alpha-substituted carboxylic acids as ppar modulators |
BRPI0409465A (pt) * | 2003-04-17 | 2006-05-02 | Pfizer Prod Inc | derivados de carboxamida como agentes antidiabéticos |
WO2004096768A1 (en) * | 2003-04-30 | 2004-11-11 | Pfizer Products Inc. | Anti-diabetic agents |
CA2525502C (en) * | 2003-05-21 | 2012-12-18 | Prosidion Limited | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
WO2004113345A1 (ja) * | 2003-06-20 | 2004-12-29 | Japan Tobacco Inc. | 縮合ピロール化合物及びその医薬用途 |
EP1709004A2 (en) | 2003-12-29 | 2006-10-11 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
ES2353309T3 (es) | 2004-03-08 | 2011-03-01 | Prosidion Ltd. | Hidrazidas del ácido pirrolopiridin-2-carboxílico como inhibidores de glucógeno fosforilasa. |
US9737511B2 (en) * | 2004-05-24 | 2017-08-22 | Geoffrey C. GURTNER | Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux |
EP1755579A4 (en) * | 2004-05-24 | 2009-06-10 | Univ New York | METHOD FOR TREATING OR PREVENTING PATHOLOGICAL EFFECTS OF AN ACUTE INCREASE OF HYPERGLYCEMIA AND / OR ACUTE INCREASE IN FREE FATTY ACID FLUID |
WO2006041922A2 (en) * | 2004-10-08 | 2006-04-20 | Dara Biosciences, Inc. | Agents and methods for administration to the central nervous system |
WO2006053274A2 (en) | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
US7365061B2 (en) | 2004-11-15 | 2008-04-29 | Bristol-Myers Squibb Company | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
US7223786B2 (en) | 2004-11-15 | 2007-05-29 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
WO2006055462A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006059163A1 (en) * | 2004-12-02 | 2006-06-08 | Prosidion Limited | Treatment of diabetes with glycogen phosphorylase inhibitors |
KR20070102694A (ko) * | 2005-01-31 | 2007-10-19 | 아지노모토 가부시키가이샤 | 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물 |
WO2006088798A2 (en) * | 2005-02-14 | 2006-08-24 | Albert Einstein College Of Medicine Of Yeshiva University | Modulation of hypothalamic atp-sensitive potassium channels |
JP2009500425A (ja) | 2005-07-06 | 2009-01-08 | セプラコア インコーポレーテッド | エスゾピクロン及びトランス4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロ−n−メチル−1−ナフタレンアミン又はトランス4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロ−1−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法 |
ES2594156T3 (es) | 2006-01-06 | 2016-12-16 | Sunovion Pharmaceuticals Inc. | Cicloalquilaminas como inhibidores de la recaptación de monoaminas |
US8053603B2 (en) | 2006-01-06 | 2011-11-08 | Sunovion Pharmaceuticals Inc. | Tetralone-based monoamine reuptake inhibitors |
DK2816024T3 (en) | 2006-03-31 | 2017-10-30 | Sunovion Pharmaceuticals Inc | CHIRALE AMINER |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
BRPI0713216A2 (pt) * | 2006-06-30 | 2012-12-04 | Sepracor Inc | inibiadores heterocìclos fundidos da d-aminoácido oxidase |
US20080058395A1 (en) * | 2006-06-30 | 2008-03-06 | Sepracor Inc. | Fused heterocyclic inhibitors of D-amino acid oxidase |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
JP5306818B2 (ja) * | 2006-10-18 | 2013-10-02 | 武田薬品工業株式会社 | 縮合複素環化合物 |
AU2008206039A1 (en) * | 2007-01-18 | 2008-07-24 | Sepracor Inc. | Inhibitors of D-amino acid oxidase |
US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
WO2008151156A1 (en) | 2007-05-31 | 2008-12-11 | Sepracor Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
WO2010017418A1 (en) * | 2008-08-07 | 2010-02-11 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
US10098857B2 (en) | 2008-10-10 | 2018-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds |
US20100152200A1 (en) * | 2008-11-17 | 2010-06-17 | The Regents Of The University Of Michigan | Alphavirus inhibitors and uses thereof |
WO2011017634A2 (en) * | 2009-08-07 | 2011-02-10 | Sepracore Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
MY188344A (en) | 2012-03-09 | 2021-12-01 | Biotropics Malaysia Berhad | Extract formulations of rhodamnia cinerea and uses thereof |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
GB201708451D0 (en) * | 2017-05-26 | 2017-07-12 | Univ Oxford Innovation Ltd | Inhibitors of metallo-beta-lactamases |
US11331288B2 (en) | 2017-09-14 | 2022-05-17 | The Board Of Trustees Of The Leland Stanford Junior University | Conditioning irradiated tissue for increasing vascularity |
EP3795559B1 (en) | 2018-05-15 | 2024-07-31 | Asahi Kasei Kabushiki Kaisha | Method for producing amino acid aminoalkyl ester or inorganic acid salt thereof |
CN111468183A (zh) * | 2019-11-25 | 2020-07-31 | 天津大学 | 多氟代三芳基手性螺环磷酸催化剂及其制备方法、用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0031088A1 (de) * | 1979-12-19 | 1981-07-01 | Hoechst Aktiengesellschaft | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen sowie ihre Verwendung |
ES2081747B1 (es) * | 1993-09-07 | 1997-01-16 | Esteve Labor Dr | Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos. |
FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
ATE205477T1 (de) * | 1995-06-06 | 2001-09-15 | Pfizer | Substituierte n-(indol-2-carbonyl)-amide und derivate als glycogen phosphorylase inhibitoren |
US5952322A (en) * | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
EP0901786B1 (en) * | 1997-08-11 | 2007-06-13 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
US5939417A (en) * | 1998-10-19 | 1999-08-17 | Cell Pathways Inc | 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia |
-
2000
- 2000-09-18 DE DE60007592T patent/DE60007592T2/de not_active Expired - Fee Related
- 2000-09-18 EP EP00308131A patent/EP1088824B1/en not_active Expired - Lifetime
- 2000-09-18 DK DK00308131T patent/DK1088824T3/da active
- 2000-09-18 AT AT00308131T patent/ATE257480T1/de not_active IP Right Cessation
- 2000-09-18 PT PT00308131T patent/PT1088824E/pt unknown
- 2000-09-18 ES ES00308131T patent/ES2211454T3/es not_active Expired - Lifetime
- 2000-09-20 JP JP2000285363A patent/JP3489819B2/ja not_active Expired - Fee Related
- 2000-09-27 US US09/670,759 patent/US6399601B1/en not_active Expired - Fee Related
- 2000-09-28 CA CA002321379A patent/CA2321379A1/en not_active Abandoned
- 2000-10-02 BR BR0004582-9A patent/BR0004582A/pt not_active IP Right Cessation
-
2002
- 2002-04-05 US US10/117,370 patent/US6576653B2/en not_active Expired - Fee Related
-
2003
- 2003-02-14 US US10/367,002 patent/US6828343B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2211454T3 (es) | 2004-07-16 |
ATE257480T1 (de) | 2004-01-15 |
CA2321379A1 (en) | 2001-03-30 |
US6576653B2 (en) | 2003-06-10 |
US6399601B1 (en) | 2002-06-04 |
BR0004582A (pt) | 2001-04-17 |
JP3489819B2 (ja) | 2004-01-26 |
US20020183369A1 (en) | 2002-12-05 |
EP1088824A3 (en) | 2001-06-27 |
DE60007592T2 (de) | 2004-09-16 |
EP1088824A2 (en) | 2001-04-04 |
US20030195361A1 (en) | 2003-10-16 |
EP1088824B1 (en) | 2004-01-07 |
JP2001131181A (ja) | 2001-05-15 |
US6828343B2 (en) | 2004-12-07 |
DE60007592D1 (de) | 2004-02-12 |
DK1088824T3 (da) | 2004-04-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT1088824E (pt) | Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilase | |
MXPA05011702A (es) | Agentes antidiabeticos. | |
BR0316099A (pt) | Agentes antidiabéticos | |
EA200970585A1 (ru) | Бензамидные производные как агонисты ер-рецепторов | |
PT1349843E (pt) | Derivados de tiazolo e de oxazolo como activadores dos receptores activados por proliferadores de peroxissomas humanos | |
DK1213296T3 (da) | Glucopyranosyloxpyrazolderivater, lægemidler indeholdende samme samt mellemprodukter til fremstilling heraf | |
BR0000968A (pt) | ácidos oxâmicos contendo ciano e seus derivados como ligantes de receptores da tiróide | |
EE200300403A (et) | N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina | |
DK1487444T3 (da) | Anvendelse af pyridylamider som angiogeneseinhibitorer | |
CY1105631T1 (el) | Υποκατεστημενα παραγωγα καρβοστυριλης ως αγωνιστες 5-ητ1α υποτυπου δεκτη | |
WO2007039883A3 (en) | Process for preparation of aprepitant | |
ATE523498T1 (de) | Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivate | |
NO20032261D0 (no) | Medisinske preparater | |
SI1578741T1 (sl) | Aromatske spojine kot protivnetna imunomodulatorna in antiproliferativna sredstva | |
EP1914229A4 (en) | NOVEL CERCOSPORAMIDE DERIVATIVES | |
WO2006059164A3 (en) | Pyrrolopyridine-2-carboxylic acid amides | |
BR0209735A (pt) | Derivados heterocìclicos e uso medicinal destes | |
EA200870223A1 (ru) | Производные бензоизоиндола для лечения боли | |
ATE511506T1 (de) | Thiopen-derivate als wirkstoffe gegen okulare hypotonie | |
BR0200536A (pt) | Compostos de sulfonilpiridazinana úteis como inibidores de aldose reductase | |
BRPI0411208A (pt) | uso de derivados 2-amino-1,3-propanodiol para a fabricação de um medicamento para o tratamento de vários tipos de dor | |
DK1179342T3 (da) | Medicinske sammensætninger til öjeblikkelig frigivelse ved oral anvendelse | |
BRPI0406990A (pt) | Derivado de oligossacarìdeo | |
SI1924255T1 (sl) | Uporaba n-(dibenz(b,f)oksepin-10-ilmetil)-n-metil-n-prop-2-inilamina(omigapil), za profilakso in/ali zdravljenje miĺ iäśne distrofije | |
TW200642686A (en) | Aporphine or secoaporphine compounds for treatment of diabetes |