PL3204386T3 - Podstawione związki aminopurynowe, ich kompozycje i sposoby leczenia nimi - Google Patents

Podstawione związki aminopurynowe, ich kompozycje i sposoby leczenia nimi

Info

Publication number: PL3204386T3
Authority: PL; Poland
Prior art keywords: compositions; methods; aminopurine compounds; treatment therewith; substituted aminopurine
Prior art date: 2014-10-06

Application number

PL15848476T

Other languages

English (en)

Inventor

Matthew Alexander

Sogole Bahmanyar

John Fredrerick Boylan

Joshua Hansen

Dehua Huang

Robert Hubbard

Brandon Jeffy

Jim Leisten

Mehran Moghaddam

Raj K. Raheja

Heather Raymon

Kimberly Schwarz

Marianne Sloss

Eduardo Torres

Tam Minh Tran

Shuichan Xu

Jingjing Zhao

Original Assignee

Signal Pharmaceuticals, Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-06

Filing date

2015-10-05

Publication date

2021-09-20

2015-10-05 Application filed by Signal Pharmaceuticals, Llc filed Critical Signal Pharmaceuticals, Llc

2021-09-20 Publication of PL3204386T3 publication Critical patent/PL3204386T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL15848476T 2014-10-06 2015-10-05 Podstawione związki aminopurynowe, ich kompozycje i sposoby leczenia nimi PL3204386T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462060339P	2014-10-06	2014-10-06
PCT/US2015/053941 WO2016057370A1 (en)	2014-10-06	2015-10-05	Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
EP15848476.6A EP3204386B1 (en)	2014-10-06	2015-10-05	Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

Publications (1)

Publication Number	Publication Date
PL3204386T3 true PL3204386T3 (pl)	2021-09-20

Family

ID=55632334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL15848476T PL3204386T3 (pl)	2014-10-06	2015-10-05	Podstawione związki aminopurynowe, ich kompozycje i sposoby leczenia nimi

Country Status (27)

Country	Link
US (8)	US9512124B2 (pl)
EP (2)	EP3822274B1 (pl)
JP (4)	JP6884701B2 (pl)
KR (2)	KR102504849B1 (pl)
CN (2)	CN107001372B (pl)
AR (2)	AR102171A1 (pl)
AU (2)	AU2015328414B2 (pl)
CA (1)	CA2963639C (pl)
CL (1)	CL2017000820A1 (pl)
CO (1)	CO2017003838A2 (pl)
CY (1)	CY1124173T1 (pl)
DK (1)	DK3204386T3 (pl)
EA (1)	EA201790779A1 (pl)
EC (1)	ECSP17026210A (pl)
ES (2)	ES2980464T3 (pl)
HR (1)	HRP20210656T1 (pl)
HU (1)	HUE054694T2 (pl)
IL (2)	IL251566B (pl)
LT (1)	LT3204386T (pl)
MX (2)	MX2017004600A (pl)
PL (1)	PL3204386T3 (pl)
PT (1)	PT3204386T (pl)
RS (1)	RS61884B1 (pl)
SG (2)	SG10202009598VA (pl)
SI (1)	SI3204386T1 (pl)
TW (1)	TW201629063A (pl)
WO (1)	WO2016057370A1 (pl)

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PL3204386T3 (pl) *	2014-10-06	2021-09-20	Signal Pharmaceuticals, Llc	Podstawione związki aminopurynowe, ich kompozycje i sposoby leczenia nimi
JP6903577B2 (ja)	2014-12-16	2021-07-14	シグナルファーマシューティカルズ，エルエルシー	皮膚におけるｃ−ＪｕｎＮ末端キナーゼの阻害の測定方法
WO2016123291A1 (en)	2015-01-29	2016-08-04	Signal Pharmaceuticals, Llc	Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
EP3271360B1 (en)	2015-03-18	2020-04-22	Bristol-Myers Squibb Company	Substituted tricyclic heterocyclic compounds
JP6793658B2 (ja)	2015-03-18	2020-12-02	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｔｎｆ阻害剤として有用な三環式ヘテロ環式化合物
KR102696304B1 (ko)	2015-03-18	2024-08-16	브리스톨-마이어스 스큅 컴퍼니	Tnf의 억제제로서 유용한 헤테로시클릭 화합물
EP3795553B1 (en)	2015-07-24	2024-05-15	Celgene Corporation	Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
JP6811233B2 (ja)	2015-08-03	2021-01-13	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｔｎｆアルファの修飾因子として有用な環状化合物
NZ746554A (en) *	2016-04-01	2023-03-31	Signal Pharm Llc	Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
MX2018011970A (es) *	2016-04-01	2019-05-20	Signal Pharm Llc	Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas.
EP3464312A4 (en)	2016-06-02	2019-11-27	Celgene Corporation	ANTI-TRYPANOSOMA AND ANTI-LEISHMANIA AGENTS FOR ANIMALS AND HUMANS
JP6970126B2 (ja) *	2016-06-02	2021-11-24	セルジーンコーポレイション	動物及びヒトの抗マラリア薬
BR122022005778B1 (pt)	2017-10-04	2024-01-09	Celgene Corporation	Cápsula compreendendo cis-4-[2-{[(3s,4r)-3-fluoro-oxan-4-il]amino}-8-(2,4,6-tricloroanilino)-9h-purin-9-il]-1-metilciclohexano-1-carboxamida
JP2020536100A (ja) *	2017-10-04	2020-12-10	セルジーンコーポレイション	シス−４−［２−｛［（３ｓ，４ｒ）−３−フルオロキサン−４−イル］アミノ｝−８−（２，４，６−トリクロロアニリノ）−９ｈ−プリン−９−イル］−１−メチルシクロヘキサン−１−カルボキサミドの製造プロセス
CN115916747A (zh) *	2020-07-01	2023-04-04	四川海思科制药有限公司	一种并环杂环衍生物及其在医药上的应用
US12084453B2 (en)	2021-12-10	2024-09-10	Incyte Corporation	Bicyclic amines as CDK12 inhibitors
CN114478326B (zh) *	2022-01-21	2023-10-03	安徽宁亿泰科技有限公司	一种苯嘧磺草胺关键中间体的合成方法

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IL99699A (en)	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
FI109088B (fi)	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
CZ27399A3 (cs)	1999-01-26	2000-08-16	Ústav Experimentální Botaniky Av Čr	Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
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PL3204386T3 (pl) *	2014-10-06	2021-09-20	Signal Pharmaceuticals, Llc	Podstawione związki aminopurynowe, ich kompozycje i sposoby leczenia nimi
MX2018011970A (es)	2016-04-01	2019-05-20	Signal Pharm Llc	Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas.

2015
- 2015-10-05 PL PL15848476T patent/PL3204386T3/pl unknown
- 2015-10-05 SI SI201531584T patent/SI3204386T1/sl unknown
- 2015-10-05 EA EA201790779A patent/EA201790779A1/ru unknown
- 2015-10-05 KR KR1020177010551A patent/KR102504849B1/ko active IP Right Grant
- 2015-10-05 RS RS20210632A patent/RS61884B1/sr unknown
- 2015-10-05 CN CN201580065272.2A patent/CN107001372B/zh active Active
- 2015-10-05 DK DK15848476.6T patent/DK3204386T3/da active
- 2015-10-05 SG SG10202009598VA patent/SG10202009598VA/en unknown
- 2015-10-05 ES ES20214685T patent/ES2980464T3/es active Active
- 2015-10-05 MX MX2017004600A patent/MX2017004600A/es unknown
- 2015-10-05 US US14/874,513 patent/US9512124B2/en active Active
- 2015-10-05 TW TW104132732A patent/TW201629063A/zh unknown
- 2015-10-05 AR ARP150103202A patent/AR102171A1/es not_active Application Discontinuation
- 2015-10-05 JP JP2017538172A patent/JP6884701B2/ja active Active
- 2015-10-05 EP EP20214685.8A patent/EP3822274B1/en active Active
- 2015-10-05 EP EP15848476.6A patent/EP3204386B1/en active Active
- 2015-10-05 CN CN202110381676.XA patent/CN113248506A/zh active Pending
- 2015-10-05 HU HUE15848476A patent/HUE054694T2/hu unknown
- 2015-10-05 PT PT158484766T patent/PT3204386T/pt unknown
- 2015-10-05 WO PCT/US2015/053941 patent/WO2016057370A1/en active Application Filing
- 2015-10-05 KR KR1020237006598A patent/KR20230035424A/ko active Application Filing
- 2015-10-05 CA CA2963639A patent/CA2963639C/en active Active
- 2015-10-05 LT LTEP15848476.6T patent/LT3204386T/lt unknown
- 2015-10-05 AU AU2015328414A patent/AU2015328414B2/en active Active
- 2015-10-05 ES ES15848476T patent/ES2871142T3/es active Active
- 2015-10-05 SG SG11201702759XA patent/SG11201702759XA/en unknown
2016
- 2016-10-27 US US15/335,619 patent/US9737541B2/en active Active
2017
- 2017-04-04 IL IL251566A patent/IL251566B/en active IP Right Grant
- 2017-04-04 CL CL2017000820A patent/CL2017000820A1/es unknown
- 2017-04-06 MX MX2021014531A patent/MX2021014531A/es unknown
- 2017-04-20 CO CONC2017/0003838A patent/CO2017003838A2/es unknown
- 2017-04-27 EC ECIEPI201726210A patent/ECSP17026210A/es unknown
- 2017-07-05 US US15/641,383 patent/US10149849B2/en active Active
2018
- 2018-10-24 US US16/169,414 patent/US10398700B2/en active Active
2019
- 2019-07-17 US US16/514,749 patent/US10646493B2/en active Active
- 2019-10-02 JP JP2019182133A patent/JP6987823B2/ja active Active
2020
- 2020-02-28 AU AU2020201486A patent/AU2020201486B2/en active Active
- 2020-04-13 US US16/846,503 patent/US10940152B2/en active Active
- 2020-09-01 IL IL277069A patent/IL277069B/en unknown
2021
- 2021-01-12 US US17/147,127 patent/US11590139B2/en active Active
- 2021-04-26 HR HRP20210656TT patent/HRP20210656T1/hr unknown
- 2021-05-24 CY CY20211100444T patent/CY1124173T1/el unknown
- 2021-12-01 JP JP2021195105A patent/JP7196270B2/ja active Active
2022
- 2022-12-14 JP JP2022199122A patent/JP2023027269A/ja active Pending
2023
- 2023-01-11 US US18/095,670 patent/US20230158035A1/en active Pending
- 2023-03-09 AR ARP230100589A patent/AR128748A2/es unknown

Also Published As

Publication number	Publication date
US20190091230A1 (en)	2019-03-28
AU2020201486A1 (en)	2020-03-19
JP6884701B2 (ja)	2021-06-09
EP3822274A1 (en)	2021-05-19
RS61884B1 (sr)	2021-06-30
EP3204386A4 (en)	2018-04-18
BR112017006998A2 (pt)	2018-01-16
IL251566B (en)	2020-09-30
TW201629063A (zh)	2016-08-16
AU2015328414A1 (en)	2017-04-27
AU2020201486B2 (en)	2021-07-08
US10398700B2 (en)	2019-09-03
JP2020033352A (ja)	2020-03-05
MX2017004600A (es)	2017-06-30
US20160096841A1 (en)	2016-04-07
KR20230035424A (ko)	2023-03-13
KR20170063740A (ko)	2017-06-08
LT3204386T (lt)	2021-07-12
US9737541B2 (en)	2017-08-22
US11590139B2 (en)	2023-02-28
ECSP17026210A (es)	2017-05-31
AR102171A1 (es)	2017-02-08
CN107001372A (zh)	2017-08-01
PT3204386T (pt)	2021-05-31
CO2017003838A2 (es)	2017-07-11
JP6987823B2 (ja)	2022-01-05
EA201790779A1 (ru)	2017-09-29
US20170042902A1 (en)	2017-02-16
NZ767954A (en)	2024-02-23
IL251566A0 (en)	2017-05-29
SG11201702759XA (en)	2017-05-30
US20170296546A1 (en)	2017-10-19
JP7196270B2 (ja)	2022-12-26
IL277069B (en)	2022-05-01
SI3204386T1 (sl)	2021-08-31
IL277069A (en)	2020-10-29
US20190336507A1 (en)	2019-11-07
NZ730753A (en)	2024-02-23
EP3204386A1 (en)	2017-08-16
WO2016057370A1 (en)	2016-04-14
DK3204386T3 (da)	2021-05-25
AR128748A2 (es)	2024-06-12
HRP20210656T1 (hr)	2021-07-23
JP2023027269A (ja)	2023-03-01
KR102504849B1 (ko)	2023-03-02
JP2017530199A (ja)	2017-10-12
HUE054694T2 (hu)	2021-09-28
SG10202009598VA (en)	2020-10-29
US10940152B2 (en)	2021-03-09
ES2980464T3 (es)	2024-10-01
US9512124B2 (en)	2016-12-06
US10646493B2 (en)	2020-05-12
CA2963639A1 (en)	2016-04-14
EP3822274B1 (en)	2024-03-06
US20200237768A1 (en)	2020-07-30
CL2017000820A1 (es)	2017-12-15
US20210128565A1 (en)	2021-05-06
JP2022033858A (ja)	2022-03-02
ES2871142T3 (es)	2021-10-28
EP3204386B1 (en)	2021-03-03
US20230158035A1 (en)	2023-05-25
AU2015328414B2 (en)	2020-03-19
CY1124173T1 (el)	2022-05-27
CN107001372B (zh)	2021-04-27
MX2021014531A (es)	2022-01-06
US10149849B2 (en)	2018-12-11
CA2963639C (en)	2023-07-04
CN113248506A (zh)	2021-08-13

Publication	Publication Date	Title
IL277069B (en)	2022-05-01	Modified aminopurine compounds, their compositions and methods of treatment with them
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