PL1613288T3 - Stała kompozycja farmaceutyczna zawierająca agonistę receptora S1P oraz alkohol cukrowy - Google Patents

Stała kompozycja farmaceutyczna zawierająca agonistę receptora S1P oraz alkohol cukrowy

Info

Publication number: PL1613288T3
Authority: PL; Poland
Prior art keywords: pharmaceutical compositions; receptor agonist; sugar alcohol; solid pharmaceutical; solid
Prior art date: 2003-04-08

Application number

PL04725895T

Other languages

English (en)

Inventor

Tomoyuki Oomura

Madhusudhan Pudipeddi

Alan Edward Royce

Colleen Ruegger

Masaki Sasaki

Tokuhiro Tamura

Original Assignee

Novartis Ag

Mitsubishi Tanabe Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-08

Filing date

2004-04-06

Publication date

2009-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1613288(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-04-06 Application filed by Novartis Ag, Mitsubishi Tanabe Pharma Corp filed Critical Novartis Ag

2009-07-31 Publication of PL1613288T3 publication Critical patent/PL1613288T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oil, Petroleum & Natural Gas (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Virology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

PL04725895T 2003-04-08 2004-04-06 Stała kompozycja farmaceutyczna zawierająca agonistę receptora S1P oraz alkohol cukrowy PL1613288T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US46121503P	2003-04-08	2003-04-08
PCT/EP2004/003656 WO2004089341A1 (en)	2003-04-08	2004-04-06	Organic compounds
EP04725895A EP1613288B1 (en)	2003-04-08	2004-04-06	Solid pharmaceutical compositions comprising a s1p receptor agonist and a sugar alcohol

Publications (1)

Publication Number	Publication Date
PL1613288T3 true PL1613288T3 (pl)	2009-07-31

Family

ID=32326722

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL04725895T PL1613288T3 (pl)	2003-04-08	2004-04-06	Stała kompozycja farmaceutyczna zawierająca agonistę receptora S1P oraz alkohol cukrowy
PL10184951.1T PL2316431T3 (pl)	2003-04-08	2004-04-06	Kompozycja w postaci stałego preparatu do stosowania doustnego obejmująca agonistę receptora S1P i alkohol cukrowy

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL10184951.1T PL2316431T3 (pl)	2003-04-08	2004-04-06	Kompozycja w postaci stałego preparatu do stosowania doustnego obejmująca agonistę receptora S1P i alkohol cukrowy

Country Status (42)

Country	Link
US (11)	US20060275357A1 (pl)
EP (5)	EP1613288B1 (pl)
JP (3)	JP5495467B2 (pl)
KR (3)	KR101367574B1 (pl)
CN (2)	CN101797241B (pl)
AR (3)	AR043987A1 (pl)
AT (3)	AT501681B1 (pl)
AU (1)	AU2004228929B2 (pl)
BE (2)	BE1015972A5 (pl)
BR (1)	BRPI0409250B8 (pl)
CA (2)	CA2707750A1 (pl)
CL (2)	CL2004000745A1 (pl)
CY (3)	CY1110260T1 (pl)
DE (4)	DE602004017847D1 (pl)
DK (2)	DK1613288T3 (pl)
EC (1)	ECSP056090A (pl)
ES (3)	ES2320767T3 (pl)
FR (2)	FR2854073B1 (pl)
GB (1)	GB2400318B (pl)
GR (1)	GR1005052B (pl)
HK (3)	HK1071685A1 (pl)
HR (3)	HRP20050886B1 (pl)
HU (2)	HUE028247T2 (pl)
IL (3)	IL170888A (pl)
IS (2)	IS2682B (pl)
IT (1)	ITMI20040682A1 (pl)
LU (1)	LU91867I2 (pl)
MA (1)	MA27729A1 (pl)
MX (1)	MXPA05010860A (pl)
MY (1)	MY141249A (pl)
NO (4)	NO329332B1 (pl)
NZ (3)	NZ592339A (pl)
PE (5)	PE20090743A1 (pl)
PL (2)	PL1613288T3 (pl)
PT (1)	PT1613288E (pl)
RU (5)	RU2358716C2 (pl)
SG (1)	SG175449A1 (pl)
SI (2)	SI1613288T1 (pl)
TN (1)	TNSN05256A1 (pl)
TW (1)	TWI332847B (pl)
WO (1)	WO2004089341A1 (pl)
ZA (1)	ZA200507394B (pl)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1773307B8 (en) *	2004-07-30	2014-12-17	Novartis AG	Compound formulations of 2-amino-1,3-propanediol compounds
CN1891212B (zh) *	2005-07-07	2010-10-13	马启明	一种口服制剂及其制备方法
AU2006289100B2 (en)	2005-09-09	2010-07-22	Novartis Ag	Treatment of autoimmune diseases
PL1948678T3 (pl)	2005-11-09	2013-09-30	Onyx Therapeutics Inc	Związki do hamowania enzymów
TWI389683B (zh) *	2006-02-06	2013-03-21	Kyorin Seiyaku Kk	A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
EP2041158B1 (en)	2006-06-19	2013-04-17	Onyx Therapeutics, Inc.	Peptide epoxyketones for proteasome inhibition
GB0612721D0 (en)	2006-06-27	2006-08-09	Novartis Ag	Organic compounds
EP1905434A1 (en) *	2006-09-26	2008-04-02	Novartis AG	Organic compounds comprising an S1P receptor agonist and their therapeutic use
AU2011235934A1 (en) *	2006-09-26	2011-11-03	Novartis Ag	Pharmaceutical compositions comprising an S1P modulator
EP1923054A1 (en) *	2006-09-26	2008-05-21	Novartis AG	Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
EP1923058A1 (en) *	2006-09-26	2008-05-21	Novartis AG	Coated pharmaceutical composition comprising an S1P agonist or modulator
EP1923055A1 (en) *	2006-09-26	2008-05-21	Novartis AG	Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
MX2009002993A (es) *	2006-09-26	2009-04-01	Novartis Ag	Composiciones farmaceuticas que comprenden un modulador de s1p.
WO2008124210A1 (en) *	2007-02-14	2008-10-16	Emory University	Methods and compositions for treating or preventing infection using leukocyte sequestration agents
WO2008129846A1 (ja) *	2007-03-29	2008-10-30	Daiichi Sankyo Company, Limited	医薬組成物
PL2207791T5 (pl)	2007-10-04	2020-07-27	Onyx Therapeutics, Inc.	Krystaliczne peptydo- epoksy ketonowe inhibitory proteazy i synteza keto-epoksydów Aminokwasowych
AU2012216630B2 (en) *	2007-10-12	2015-01-22	Novartis Ag	Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
MY159358A (en) *	2007-10-12	2016-12-30	Novartis Ag	Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
JP5534645B2 (ja) *	2008-01-11	2014-07-02	日医工株式会社	無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤
JP5452237B2 (ja)	2008-02-07	2014-03-26	杏林製薬株式会社	アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
LT2278960T (lt)	2008-03-17	2017-02-10	Actelion Pharmaceuticals Ltd.	S1p1 receptoriaus selektyvaus agonisto dozavimo režimas
MX2010014223A (es)	2008-06-20	2011-01-21	Novartis Ag	Composiciones pediatricas para el tratamiento de esclerosis multiple.
CA2728436C (en) *	2008-06-20	2016-07-26	Merck Patent Gmbh	Directly compressible and rapidly disintegrating tablet matrix
KR101651702B1 (ko) *	2008-09-04	2016-08-26	카아길, 인코포레이팃드	에리쓰리톨 정제
EP3090737A1 (en)	2008-10-21	2016-11-09	Onyx Therapeutics, Inc.	Combination therapy with peptide epoxyketones
AU2013100531B4 (en) *	2008-11-11	2013-11-28	Novartis Ag	Crystalline forms of fingolimod HCL
BRPI0921533A2 (pt)	2008-11-11	2016-01-12	Novartis Ag	composto orgânicos
EP2356090B1 (en) *	2008-11-11	2017-07-05	Novartis AG	Crystalline forms of fingolimod hcl
RU2464271C1 (ru)	2008-12-17	2012-10-20	Дайити Санкио Компани, Лимитед	Способ получения производного диамина
EP2383272A4 (en)	2009-01-13	2012-07-25	Daiichi Sankyo Co Ltd	INHIBITOR OF AN ACTIVE FACTOR OF BLOOD COAGULATION
CN102348688B (zh)	2009-03-10	2014-07-09	第一三共株式会社	用于制备二胺衍生物的方法
CN102348680B (zh)	2009-03-13	2014-11-05	第一三共株式会社	用于制备光学活性二胺衍生物的方法
TWI504598B (zh)	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
JPWO2010147169A1 (ja) *	2009-06-18	2012-12-06	第一三共株式会社	溶出性の改善された医薬組成物
US9675566B2 (en)	2009-07-16	2017-06-13	Pathologica Llc	Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
JP5919196B2 (ja)	2009-11-13	2016-05-18	オニキスセラピューティクス，インク．ＯｎｙｘＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	転移抑制のためのペプチドエポキシケトンの使用
CA2791651C (en)	2010-03-01	2019-08-20	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
BR112012023654B1 (pt)	2010-03-19	2022-04-12	Daiichi Sankyo Company, Limited	Método para produzir grânulos contendo agente anticoagulante e método para produzir uma composição farmacêutica contendo o dito agente
WO2011115066A1 (ja)	2010-03-19	2011-09-22	第一三共株式会社	ジアミン誘導体の結晶およびその製造方法
EP2560619A2 (en) *	2010-04-22	2013-02-27	Ratiopharm GmbH	A method of preparing an oral dosage form comprising fingolimod
KR101795096B1 (ko)	2010-07-02	2017-12-01	다이이찌 산쿄 가부시키가이샤	광학 활성 디아민 유도체의 염의 제조 방법
EP2646409A4 (en)	2010-11-25	2015-12-16	Shilpa Medicare Ltd	FINGOLIMODE POLYMORPHS AND METHODS THEREOF
LT2661261T (lt)	2011-01-07	2019-10-25	Novartis Ag	Imunosupresantų kompozicijos
ES2662373T3 (es)	2011-01-19	2018-04-06	Pathologica, Llc.	Formas de dosificación farmacéutica oral de liberación controlada que comprenden MGBG
AR085749A1 (es) *	2011-04-01	2013-10-23	Novartis Ag	Formulaciones
WO2013019872A1 (en)	2011-08-01	2013-02-07	Teva Pharmaceutical Industries Ltd.	Process for preparing pharmaceutical compositions comprising fingolimod
JPWO2013022059A1 (ja)	2011-08-10	2015-03-05	第一三共株式会社	ジアミン誘導体含有医薬組成物
WO2013091704A1 (en)	2011-12-22	2013-06-27	Synthon Bv	Pharmaceutical composition comprising fingolimod
RU2482842C1 (ru) *	2012-04-26	2013-05-27	Открытое акционерное общество "Новосибхимфарм"	Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения
RU2506949C1 (ru) *	2012-06-13	2014-02-20	Открытое акционерное общество "Новосибхимфарм"	Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
US20140105921A1 (en)	2012-07-09	2014-04-17	Onyx Therapeutics, Inc.	Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
RU2496486C1 (ru) *	2012-07-11	2013-10-27	Александр Васильевич Иващенко	Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
JP6370804B2 (ja)	2013-01-08	2018-08-08	パソロジカエルエルシー	脱髄疾患の治療のための方法および組成物
WO2014141298A2 (en) *	2013-03-11	2014-09-18	Astron Research Limited	Stable pharmaceutical composition of fingolimod
JP6294872B2 (ja) *	2013-04-26	2018-03-14	国立大学法人京都大学	脳動脈瘤の形成および／または増大の抑制若しくは縮小用医薬組成物
MX370184B (es) *	2013-05-13	2019-12-04	Synthon Bv	Composición farmacéutica que comprende fingolimod.
CA2920758A1 (en) *	2013-07-29	2015-02-05	Aizant Drug Research Solutions Pvt Ltd	Pharmaceutical compositions of fingolimod
RU2530626C1 (ru) *	2013-10-21	2014-10-10	Ооо "Валента-Интеллект"	Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
CN106794159A (zh) *	2014-08-22	2017-05-31	广东东阳光药业有限公司	一种芬戈莫德固体组合物及其制备方法
WO2016042493A1 (en) *	2014-09-19	2016-03-24	Aizant Drug Research Pvt. Ltd	Pharmaceutical compositions of fingolimod
CA2974375A1 (en) *	2015-01-20	2016-07-28	Handa Pharmaceuticals, Llc	Stable solid fingolimod dosage forms
US9925138B2 (en)	2015-01-20	2018-03-27	Handa Pharmaceuticals, Llc	Stable solid fingolimod dosage forms
WO2016135644A1 (en)	2015-02-26	2016-09-01	Novartis Ag	Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
RU2577230C1 (ru) *	2015-04-09	2016-03-10	Общество с ограниченной ответственностью "Лонг Шенг Фарма Рус"	Способ получения капсул финголимода гидрохлорида
US9690975B2 (en) *	2015-05-28	2017-06-27	Axogen Corporation	Quantitative structural assay of a nerve graft
US11434200B2 (en)	2017-03-09	2022-09-06	Novartis Ag	Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
EP3419607B1 (en)	2017-03-29	2019-11-20	Deva Holding Anonim Sirketi	Stable formulations of fingolimod
GR1009654B (el)	2018-08-31	2019-11-18	Φαρματεν Α.Β.Ε.Ε.	Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
DE102018217334A1 (de) *	2018-10-10	2020-04-16	Harbins Ruhr Bioscience, Inc.	Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel
JP7503420B2 (ja) *	2020-05-18	2024-06-20	東和薬品株式会社	フィンゴリモドを含む医薬組成物とその製造方法及び安定化方法
US11298412B2 (en)	2020-07-16	2022-04-12	Harbins Ruhr Bioscience, Inc.	Sphingoid compounds for prophylaxis and/or therapy of coronaviridae infection

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7607683A (nl) *	1976-07-12	1978-01-16	Akzo Nv	Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4110332A (en) *	1977-05-05	1978-08-29	Chevron Research Company	1-Triorganostannyl-3-organothio-4-substituted-1,2,4-delta2 -triazolidin-5-ones
US4559153A (en)	1983-10-25	1985-12-17	Phillips Petroleum Company	Metal working lubricant
US5112616A (en) *	1988-11-30	1992-05-12	Schering Corporation	Fast dissolving buccal tablet
JP2841857B2 (ja) *	1990-11-29	1998-12-24	田辺製薬株式会社	長期間安定な経口用医薬製剤
US5604229A (en) *	1992-10-21	1997-02-18	Yoshitomi Pharmaceutical Industries, Ltd.	2-amino-1,3-propanediol compound and immunosuppressant
DE69524962T4 (de)	1994-08-22	2003-08-28	Mitsubishi Pharma Corp., Osaka	Benzolderivate und deren medizinische verwendung
PT812588E (pt)	1995-12-28	2005-01-31	Mitsubishi Pharma Corp	Composicao farmaceutica externa para administracao topica contendo 2-amino-2-(2-(4-octilfenil)-etil)-propano-1,3-diol para o tratamento de doencas provocadas por uma afeccao imunitaria
JP2002241272A (ja) *	1996-07-18	2002-08-28	Mitsubishi Pharma Corp	医薬処方組成物
US6476004B1 (en) *	1996-07-18	2002-11-05	Mitsubishi Pharma Corporation	Pharmaceutical composition
JPH11209277A (ja) *	1998-01-19	1999-08-03	Yoshitomi Pharmaceut Ind Ltd	医薬組成物
GB9624038D0 (en)	1996-11-19	1997-01-08	Sandoz Ltd	Organic compounds
RU2188004C2 (ru) *	1997-02-27	2002-08-27	Велфайд Корпорейшн	Фармацевтическая композиция
CA2286315C (en) *	1997-04-04	2007-03-06	Yoshitomi Pharmaceutical Industries Ltd.	2-aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor
JPH1180026A (ja)	1997-09-02	1999-03-23	Yoshitomi Pharmaceut Ind Ltd	新規免疫抑制剤、その使用方法およびその同定方法
JP3545595B2 (ja)	1998-04-01	2004-07-21	花王株式会社	スフィンゴ糖脂質の製造法
JP4627356B2 (ja) *	1999-06-30	2011-02-09	松森　　昭	ウイルス性心筋炎の予防または治療薬剤
EP1195165A4 (en) *	1999-07-12	2005-08-10	Ono Pharmaceutical Co	FIBROSIS INHIBITORS CONTAINING THE ACTIVE INGREDIENT OF SPHINGOSINE A PHOSPHATE OR ITS RECEPTOR AGONISTS
KR100812578B1 (ko)	2000-07-13	2008-03-13	상꾜 가부시키가이샤	아미노알코올 유도체
CA2421893A1 (en) *	2000-08-31	2002-03-07	Merck And Co., Inc.	Phosphate derivatives as immunoregulatory agents
US6953332B1 (en)	2000-11-28	2005-10-11	St. Jude Medical, Inc.	Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
ES2254675T3 (es)	2001-03-26	2006-06-16	Novartis Ag	Derivados del 2-amino-propanol.
US7521192B2 (en)	2001-04-18	2009-04-21	Rigel Pharmaceuticals, Inc.	EDG: modulators of lymphocyte activation and migration
JP2002316985A (ja)	2001-04-20	2002-10-31	Sankyo Co Ltd	ベンゾチオフェン誘導体
US20040235794A1 (en)	2001-09-04	2004-11-25	Shinji Nakade	Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller
DE60223699T2 (de)	2001-09-27	2008-10-30	Kyorin Pharmaceutical Co., Ltd.	Diarylsulfidderivat, dessen additionssalz und immunsuppressivum
ATE463478T1 (de)	2001-09-27	2010-04-15	Kyorin Seiyaku Kk	Diaryletherderivat, dessen additionssalz und immunosuppressivum
JP4709488B2 (ja)	2002-01-18	2011-06-22	メルク・シャープ・エンド・ドーム・コーポレイション	Ｅｄｇ受容体作動薬としてのＮ−（ベンジル）アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
AU2003207567B2 (en)	2002-01-18	2008-01-24	Merck Sharp & Dohme Corp.	Edg receptor agonists
AU2003214873A1 (en)	2002-01-18	2003-09-02	Ceretek Llc	Methods of treating conditions associated with an edg receptor
US20050070506A1 (en)	2002-01-18	2005-03-31	Doherty George A.	Selective s1p1/edg1 receptor agonists
EP1772145B1 (en) *	2004-07-16	2011-03-23	Kyorin Pharmaceutical Co., Ltd.	Method of effectively using medicine and method concerning prevention of side effect

2004
- 2004-04-06 PL PL04725895T patent/PL1613288T3/pl unknown
- 2004-04-06 BR BRPI0409250A patent/BRPI0409250B8/pt active IP Right Grant
- 2004-04-06 SI SI200431037T patent/SI1613288T1/sl unknown
- 2004-04-06 DK DK04725895T patent/DK1613288T3/da active
- 2004-04-06 FR FR0450692A patent/FR2854073B1/fr not_active Expired - Lifetime
- 2004-04-06 PE PE2008001684A patent/PE20090743A1/es not_active Application Discontinuation
- 2004-04-06 EP EP04725895A patent/EP1613288B1/en not_active Expired - Lifetime
- 2004-04-06 ES ES04725895T patent/ES2320767T3/es not_active Expired - Lifetime
- 2004-04-06 PE PE2004000355A patent/PE20050396A1/es not_active Application Discontinuation
- 2004-04-06 WO PCT/EP2004/003656 patent/WO2004089341A1/en active Application Filing
- 2004-04-06 MX MXPA05010860A patent/MXPA05010860A/es active IP Right Grant
- 2004-04-06 GR GR20040100121A patent/GR1005052B/el unknown
- 2004-04-06 PE PE2015000303A patent/PE20150676A1/es not_active Application Discontinuation
- 2004-04-06 JP JP2004111761A patent/JP5495467B2/ja not_active Expired - Lifetime
- 2004-04-06 ES ES200400852A patent/ES2228282B1/es not_active Expired - Fee Related
- 2004-04-06 AT ATA606/2004A patent/AT501681B1/de not_active IP Right Cessation
- 2004-04-06 DE DE602004017847T patent/DE602004017847D1/de not_active Expired - Lifetime
- 2004-04-06 KR KR1020127019448A patent/KR101367574B1/ko active IP Right Grant
- 2004-04-06 DE DE201112100047 patent/DE122011100047I1/de active Pending
- 2004-04-06 KR KR1020057019066A patent/KR20050121712A/ko not_active Application Discontinuation
- 2004-04-06 EP EP10186307A patent/EP2319502A1/en not_active Withdrawn
- 2004-04-06 DE DE102004016947A patent/DE102004016947A1/de active Pending
- 2004-04-06 CN CN2010101213007A patent/CN101797241B/zh not_active Expired - Lifetime
- 2004-04-06 PE PE2012002027A patent/PE20130200A1/es not_active Application Discontinuation
- 2004-04-06 EP EP10184951.1A patent/EP2316431B1/en not_active Revoked
- 2004-04-06 EP EP14163450.1A patent/EP2769713A1/en not_active Withdrawn
- 2004-04-06 AU AU2004228929A patent/AU2004228929B2/en active Active
- 2004-04-06 RU RU2005134173/15A patent/RU2358716C2/ru not_active IP Right Cessation
- 2004-04-06 CA CA2707750A patent/CA2707750A1/en not_active Abandoned
- 2004-04-06 IT IT000682A patent/ITMI20040682A1/it unknown
- 2004-04-06 KR KR1020107029859A patent/KR20110005320A/ko not_active Application Discontinuation
- 2004-04-06 SG SG2008040545A patent/SG175449A1/en unknown
- 2004-04-06 GB GB0407819A patent/GB2400318B/en not_active Expired - Lifetime
- 2004-04-06 PT PT04725895T patent/PT1613288E/pt unknown
- 2004-04-06 NZ NZ592339A patent/NZ592339A/xx not_active IP Right Cessation
- 2004-04-06 AR ARP040101162A patent/AR043987A1/es not_active Application Discontinuation
- 2004-04-06 ES ES10184951.1T patent/ES2556947T3/es not_active Expired - Lifetime
- 2004-04-06 PE PE2013000382A patent/PE20131352A1/es active IP Right Grant
- 2004-04-06 CN CN2004800092370A patent/CN1767819B/zh not_active Expired - Lifetime
- 2004-04-06 AT AT04725895T patent/ATE414508T1/de active
- 2004-04-06 PL PL10184951.1T patent/PL2316431T3/pl unknown
- 2004-04-06 SI SI200432283T patent/SI2316431T1/sl unknown
- 2004-04-06 CA CA2521325A patent/CA2521325C/en not_active Expired - Lifetime
- 2004-04-06 HU HUE10184951A patent/HUE028247T2/en unknown
- 2004-04-06 DK DK10184951.1T patent/DK2316431T3/en active
- 2004-04-06 US US10/552,005 patent/US20060275357A1/en not_active Abandoned
- 2004-04-06 NZ NZ542622A patent/NZ542622A/xx not_active IP Right Cessation
- 2004-04-06 EP EP08161161A patent/EP2008650A3/en not_active Withdrawn
- 2004-04-06 NZ NZ586280A patent/NZ586280A/en not_active IP Right Cessation
- 2004-04-06 DE DE202004021680U patent/DE202004021680U1/de not_active Expired - Lifetime
- 2004-04-07 CL CL200400745A patent/CL2004000745A1/es unknown
- 2004-04-07 TW TW093109631A patent/TWI332847B/zh active
- 2004-04-07 MY MYPI20041275A patent/MY141249A/en unknown
- 2004-04-07 BE BE2004/0180A patent/BE1015972A5/fr not_active IP Right Cessation
2005
- 2005-03-31 HK HK05102715A patent/HK1071685A1/xx not_active IP Right Cessation
- 2005-09-14 ZA ZA200507394A patent/ZA200507394B/en unknown
- 2005-09-15 IL IL170888A patent/IL170888A/en active IP Right Grant
- 2005-10-06 HR HR20050886A patent/HRP20050886B1/xx not_active IP Right Cessation
- 2005-10-07 TN TNP2005000256A patent/TNSN05256A1/en unknown
- 2005-10-07 EC EC2005006090A patent/ECSP056090A/es unknown
- 2005-10-19 MA MA28560A patent/MA27729A1/fr unknown
- 2005-11-01 IS IS8114A patent/IS2682B/is unknown
- 2005-11-07 NO NO20055231A patent/NO329332B1/no active Protection Beyond IP Right Term
2006
- 2006-07-06 HK HK06107621.6A patent/HK1091114A1/xx not_active IP Right Cessation
2008
- 2008-05-08 AT AT0074408A patent/AT504853A2/de not_active Application Discontinuation
- 2008-08-11 US US12/189,323 patent/US8324283B2/en not_active Expired - Fee Related
- 2008-08-13 US US12/191,098 patent/US20090203798A1/en not_active Abandoned
2009
- 2009-02-17 RU RU2009105403/15A patent/RU2009105403A/ru not_active Application Discontinuation
- 2009-02-19 CY CY20091100192T patent/CY1110260T1/el unknown
- 2009-03-12 IL IL197578A patent/IL197578A/en active IP Right Grant
2010
- 2010-02-18 NO NO20100250A patent/NO334116B1/no unknown
- 2010-02-25 IS IS8885A patent/IS8885A/is unknown
- 2010-08-25 JP JP2010188835A patent/JP5543298B2/ja not_active Expired - Lifetime
- 2010-10-26 AR ARP100103931A patent/AR078782A2/es not_active Application Discontinuation
- 2010-10-26 AR ARP100103930A patent/AR078781A2/es not_active Application Discontinuation
- 2010-11-08 HR HRP20100601AA patent/HRP20100601B1/hr not_active IP Right Cessation
- 2010-11-08 HR HR20100600A patent/HRP20100600A2/hr not_active Application Discontinuation
- 2010-11-17 RU RU2010146697/15A patent/RU2475236C2/ru active
- 2010-11-18 RU RU2010147000/15A patent/RU2475237C2/ru active
2011
- 2011-01-10 US US12/987,726 patent/US20110105620A1/en not_active Abandoned
- 2011-03-01 CL CL2011000450A patent/CL2011000450A1/es unknown
- 2011-09-06 HU HUS1100016C patent/HUS1100016I1/hu unknown
- 2011-09-08 CY CY2011013C patent/CY2011013I1/el unknown
- 2011-09-08 LU LU91867C patent/LU91867I2/fr unknown
- 2011-09-08 BE BE2011C030C patent/BE2011C030I2/fr unknown
- 2011-09-08 FR FR11C0036C patent/FR11C0036I2/fr active Active
- 2011-09-08 NO NO2011016C patent/NO2011016I2/no unknown
- 2011-09-21 HK HK11109933.8A patent/HK1155647A1/xx not_active IP Right Cessation
2012
- 2012-11-15 RU RU2012148593/15A patent/RU2012148593A/ru not_active Application Discontinuation
- 2012-12-20 US US13/721,278 patent/US20130108675A1/en not_active Abandoned
2013
- 2013-04-23 JP JP2013090602A patent/JP2013177404A/ja active Pending
- 2013-09-16 US US14/027,943 patent/US20140011885A1/en not_active Abandoned
- 2013-09-26 NO NO20131287A patent/NO335120B1/no unknown
2014
- 2014-05-23 US US14/285,808 patent/US20140255497A1/en not_active Abandoned
2015
- 2015-10-12 IL IL242037A patent/IL242037A0/en unknown
- 2015-12-29 CY CY20151101194T patent/CY1117071T1/el unknown
2017
- 2017-06-27 US US15/634,579 patent/US20170290787A1/en not_active Abandoned
2019
- 2019-02-13 US US16/274,357 patent/US20190175527A1/en not_active Abandoned
2020
- 2020-04-03 US US16/839,703 patent/US20200237690A1/en not_active Abandoned
2021
- 2021-10-14 US US17/501,173 patent/US20220031609A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2004307506A (ja)	2004-11-04
EP2319502A1 (en)	2011-05-11
RU2475237C2 (ru)	2013-02-20
CY2011013I2 (el)	2014-04-09
SI2316431T1 (sl)	2016-04-29
US20090203798A1 (en)	2009-08-13
ES2320767T3 (es)	2009-05-28
CN1767819B (zh)	2010-07-28
BRPI0409250B1 (pt)	2017-07-11
IL197578A0 (en)	2011-07-31
CA2707750A1 (en)	2004-10-21
AT501681B1 (de)	2012-04-15
US20060275357A1 (en)	2006-12-07
DE122011100047I1 (de)	2011-12-15
EP1613288A1 (en)	2006-01-11
AR043987A1 (es)	2005-08-17
HRP20100601B1 (hr)	2016-12-02
IL170888A (en)	2010-06-16
ES2556947T3 (es)	2016-01-21
HRP20050886B1 (en)	2011-01-31
HUE028247T2 (en)	2016-12-28
NO20131287L (no)	2006-01-09
NZ592339A (en)	2012-09-28
RU2005134173A (ru)	2006-09-10
IS8885A (is)	2010-02-25
RU2358716C2 (ru)	2009-06-20
PE20131352A1 (es)	2013-11-14
RU2009105403A (ru)	2010-08-27
FR2854073A1 (fr)	2004-10-29
SG175449A1 (en)	2011-11-28
US8324283B2 (en)	2012-12-04
IE20040246A1 (en)	2004-12-15
NZ542622A (en)	2009-01-31
JP2011006461A (ja)	2011-01-13
EP2008650A2 (en)	2008-12-31
EP2316431A1 (en)	2011-05-04
HK1071685A1 (en)	2005-07-29
CY2011013I1 (el)	2014-04-09
US20220031609A1 (en)	2022-02-03
FR2854073B1 (fr)	2008-03-14
SI1613288T1 (sl)	2009-04-30
CL2004000745A1 (es)	2005-02-11
AR078781A2 (es)	2011-11-30
LU91867I2 (fr)	2011-11-08
ITMI20040682A1 (it)	2004-07-06
US20140255497A1 (en)	2014-09-11
TNSN05256A1 (en)	2007-07-10
EP2316431B1 (en)	2015-09-30
US20080311188A1 (en)	2008-12-18
HK1091114A1 (en)	2007-01-12
NO334116B1 (no)	2013-12-16
AT501681A1 (de)	2006-10-15
CN1767819A (zh)	2006-05-03
NO20055231L (no)	2006-01-09
PL2316431T3 (pl)	2016-09-30
CN101797241B (zh)	2013-03-27
BRPI0409250B8 (pt)	2022-01-18
CY1110260T1 (el)	2014-04-09
GR20040100121A (el)	2004-12-17
RU2010147000A (ru)	2012-08-10
US20200237690A1 (en)	2020-07-30
DE202004021680U1 (de)	2010-04-22
NZ586280A (en)	2011-12-22
HUS1100016I1 (hu)	2016-08-29
HRP20100601A2 (hr)	2011-03-31
EP2769713A1 (en)	2014-08-27
GR1005052B (el)	2005-11-30
CA2521325A1 (en)	2004-10-21
BRPI0409250A (pt)	2006-03-28
US20140011885A1 (en)	2014-01-09
MY141249A (en)	2010-03-31
TWI332847B (en)	2010-11-11
NO329332B1 (no)	2010-09-27
ATE414508T1 (de)	2008-12-15
IL242037A0 (en)	2015-11-30
WO2004089341A1 (en)	2004-10-21
US20130108675A1 (en)	2013-05-02
US20110105620A1 (en)	2011-05-05
CN101797241A (zh)	2010-08-11
AU2004228929A1 (en)	2004-10-21
PE20090743A1 (es)	2009-07-17
EP1613288B1 (en)	2008-11-19
GB0407819D0 (en)	2004-05-12
HRP20100600A2 (hr)	2011-03-31
HRP20050886A2 (en)	2006-11-30
KR20110005320A (ko)	2011-01-17
MXPA05010860A (es)	2006-05-25
HK1155647A1 (en)	2012-05-25
RU2012148593A (ru)	2014-05-20
NO335120B1 (no)	2014-09-22
DE602004017847D1 (de)	2009-01-02
FR11C0036I2 (fr)	2023-12-29
ZA200507394B (en)	2007-03-28
DK2316431T3 (en)	2016-01-11
GB2400318B (en)	2005-08-10
LU91867I9 (pl)	2019-01-03
AR078782A2 (es)	2011-11-30
MA27729A1 (fr)	2006-01-02
JP2013177404A (ja)	2013-09-09
RU2010146697A (ru)	2012-05-27
AU2004228929B2 (en)	2008-02-07
NO20100250L (no)	2006-01-09
PE20050396A1 (es)	2005-07-05
BE2011C030I2 (pl)	2023-03-07
TW200503784A (en)	2005-02-01
KR20050121712A (ko)	2005-12-27
IS2682B (is)	2010-10-15
CA2521325C (en)	2010-09-14
NO2011016I2 (no)	2012-08-27
ES2228282A1 (es)	2005-04-01
PE20150676A1 (es)	2015-05-17
DE102004016947A1 (de)	2004-10-21
NO20055231D0 (no)	2005-11-07
DK1613288T3 (da)	2009-03-23
JP5543298B2 (ja)	2014-07-09
IS8114A (is)	2005-11-01
EP2008650A3 (en)	2011-04-27
US20170290787A1 (en)	2017-10-12
KR20120101148A (ko)	2012-09-12
GB2400318A (en)	2004-10-13
ECSP056090A (es)	2006-03-01
JP5495467B2 (ja)	2014-05-21
PE20130200A1 (es)	2013-03-09
KR101367574B1 (ko)	2014-02-25
IL197578A (en)	2015-10-29
PT1613288E (pt)	2009-02-25
CY1117071T1 (el)	2017-04-05
US20190175527A1 (en)	2019-06-13
ES2228282B1 (es)	2006-02-16
FR11C0036I1 (fr)	2011-10-14
NO2011016I1 (no)	2011-09-19
AT504853A2 (de)	2008-08-15
RU2475236C2 (ru)	2013-02-20
BE1015972A5 (fr)	2005-12-06
CL2011000450A1 (es)	2011-11-25

Publication	Publication Date	Title
HUS1100016I1 (hu)	2016-08-29	S1P receptor antagonistát és cukoralkoholt tartalmazó gyógyszerészeti kompozíció
IL177902A0 (en)	2006-12-31	Pharmaceutical compositions containing an interleukin-6 antagonist
IL175973A0 (en)	2006-10-05	Pharmaceutical compositions comprising lercanidipine
IL174909A (en)	2010-11-30	Pharmaceutical compositions containing an interleukin-6 antagonist
IL176122A0 (en)	2006-10-05	Pharmaceutical compositions containing an interleukin-6 antagonist
IL173913A0 (en)	2006-07-05	A pharmaceutical composition comprising a p2x7 receptor antagonist and a nonsteroidal anti inflammatory drug
EP1729744A4 (en)	2012-10-31	PHARMACEUTICAL PREPARATIONS
IL176519A0 (en)	2006-10-05	Directly compressible pharmaceutical composition for the oral administration of cci-779
GB0426301D0 (en)	2004-12-29	Pharmaceutical formulations
AU1845402A (en)	2002-06-24	Nmda receptor agonist pharmaceutical compositions
IL191804A0 (en)	2008-12-29	Solid dispersion containing an active ingredient and tablets for oral administration containing the same
EG24194A (en)	2008-10-14	5ht-a-partial agonist pharmaceutical compositions
IL177826A0 (en)	2006-12-31	Oral matrix formulations comprising licarbazepine
IL161997A0 (en)	2005-11-20	Pharmaceutical composition comprising a 5ht1 receptor agonist
IL178296A0 (en)	2007-02-11	Pharmaceutical compositions containing a gaba?? receptor agonist
GB0423800D0 (en)	2004-12-01	New pharmaceutical formulations
GB0416397D0 (en)	2004-08-25	Pharmaceutical formulations
EP1811967A4 (en)	2008-08-20	METHOD AND FORMULATIONS FOR PREPARING PHARMACEUTICAL COMPOSITIONS WITH BUPROPION
HK1105358A1 (en)	2008-02-15	Solid pharmaceutical formulation
PL1655026T3 (pl)	2010-01-29	Zawierające diacereinę i meloksikam stałe preparaty farmaceutyczne
AU2003280065A1 (en)	2004-06-15	Bupropion hydrochloride solid dosage forms
HK1094676A1 (en)	2007-04-04	Solid pharmaceutical preparation form
SI1347760T1 (en)	2005-10-31	Nmda receptor agonist pharmaceutical compositions
GB0408076D0 (en)	2004-05-12	Pharmaceutical formulations
GB0408070D0 (en)	2004-05-12	Pharmaceutical formulations