PH22271A - 5-(pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use - Google Patents

5-(pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use

Info

Publication number: PH22271A
Authority: PH; Philippines
Prior art keywords: pyridinyl; diamines; pyridine; preparation; cardiotonic
Prior art date: 1980-03-28

Application number

PH25441A

Other languages

English (en)

Inventor

Lesher George Yohe

Page Donald Frederick

Opalka Jr Chester Joseph

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-28

Filing date

1981-03-27

Publication date

1988-07-14

1981-03-27 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1988-07-14 Publication of PH22271A publication Critical patent/PH22271A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PH25441A 1980-03-28 1981-03-27 5-(pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use PH22271A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/135,100 US4297360A (en)	1980-03-28	1980-03-28	5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use

Publications (1)

Publication Number	Publication Date
PH22271A true PH22271A (en)	1988-07-14

Family

ID=22466542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH25441A PH22271A (en)	1980-03-28	1981-03-27	5-(pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use

Country Status (24)

Country	Link
US (2)	US4297360A (fr)
JP (1)	JPS56150064A (fr)
KR (1)	KR830005201A (fr)
AT (1)	ATA143781A (fr)
AU (1)	AU545667B2 (fr)
BE (1)	BE888122A (fr)
CA (1)	CA1171856A (fr)
DE (1)	DE3112251A1 (fr)
DK (1)	DK136781A (fr)
ES (1)	ES500726A0 (fr)
FI (1)	FI810920L (fr)
FR (2)	FR2479224A1 (fr)
GB (1)	GB2073185B (fr)
IE (1)	IE52712B1 (fr)
IL (1)	IL62401A (fr)
IT (1)	IT1136973B (fr)
LU (1)	LU83258A1 (fr)
NL (1)	NL8101453A (fr)
NO (1)	NO811040L (fr)
NZ (1)	NZ196641A (fr)
PH (1)	PH22271A (fr)
PT (1)	PT72743B (fr)
SE (2)	SE8101993L (fr)
ZA (1)	ZA812026B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4420617A (en) *	1980-03-28	1983-12-13	Sterling Drug Inc.	5(Pyridinyl)pyridin-2-amines
US4351941A (en) *	1981-02-04	1982-09-28	Sterling Drug Inc.	Pyridinyl-pyridines
US4374141A (en) *	1981-08-17	1983-02-15	Sterling Drug Inc.	2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use
US4361569A (en) *	1981-08-26	1982-11-30	Sterling Drug Inc.	3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof
US4465686A (en) *	1981-09-08	1984-08-14	Sterling Drug Inc.	5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
US4599423A (en) *	1982-04-26	1986-07-08	Sterling Drug Inc.	Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones
US4595762A (en) *	1982-08-25	1986-06-17	Sterling Drug Inc.	5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles
US4469699A (en) *	1982-08-25	1984-09-04	Sterling Drug Inc.	5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use
US4539327A (en) *	1982-08-25	1985-09-03	Sterling Drug Inc.	5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof
US4448780A (en) *	1982-09-03	1984-05-15	Sterling Drug Inc.	N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof
US4463008A (en) *	1982-11-10	1984-07-31	Sterling Drug Inc.	2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof
US4431651A (en) *	1982-11-18	1984-02-14	Sterling Drug Inc.	2-Pyridinones and their use as cardiotonic agents
US4451469A (en) *	1982-12-16	1984-05-29	Sterling Drug Inc.	Selected 6-alkyl-and 4,6-dialkyl-2(1H)-pyridinones as cardiotonics
US4517192A (en) *	1983-01-31	1985-05-14	Sterling Drug Inc.	6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics
IL74373A0 (en) *	1984-02-21	1985-05-31	Lilly Co Eli	Process for the preparation of diaminopyridines
EP0200024B1 (fr)	1985-04-30	1992-07-01	ARZNEIMITTELWERK DRESDEN GmbH	Pyridine-3-nitriles, leur procédé de préparation et leur utilisation pharmaceutique
US4895867A (en) *	1986-06-26	1990-01-23	Norwich Eaton Pharmaceuticals, Inc.	2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents
US4882354A (en) *	1987-12-16	1989-11-21	Norwich Eaton Pharmaceuticals, Inc.	N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
EP0326307B1 (fr) *	1988-01-23	1994-08-17	Kyowa Hakko Kogyo Co., Ltd.	Dérivés de pyridazinone et préparations pharmaceutiques les contenant
WO1992003451A1 (fr) *	1990-08-21	1992-03-05	The Upjohn Company	Derives d'acide bisphosphonique utilises comme agents anti-arthritiques
CZ403592A3 (en) *	1992-02-20	1993-12-15	Hoechst Ag	Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
EP0615825B1 (fr) *	1993-03-14	1998-11-04	WILHELM HEDRICH VAKUUMANLAGEN GmbH & Co. KG	Méthode et appareil pour remplir des moules avec une résine de coulée ou des fluides similaires coulables
US8263585B2 (en)	2007-05-04	2012-09-11	Novartis Ag	Organic compounds
US8268834B2 (en)	2008-03-19	2012-09-18	Novartis Ag	Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
JP6191883B2 (ja)	2011-08-16	2017-09-06	カーディオラピーティーワイリミテッド	制御放出製剤
CN107530337B (zh)	2014-12-22	2021-07-09	贝克心脏与糖尿病研究所	治疗方法
CN106243032A (zh) *	2016-07-20	2016-12-21	扬子江药业集团江苏海慈生物药业有限公司	一种米力农的制备方法
CN111377857B (zh) *	2018-12-30	2023-04-18	鲁南制药集团股份有限公司	一种米力农的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1322318A (en) *	1971-05-19	1973-07-04	Sterling Drug Inc	1-alkyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and esters
US3838156A (en) *	1973-03-29	1974-09-24	Sterling Drug Inc	Certain 2-substituted-6-(3 or 4-pyridyl)-nicotinic acid derivatives
US4004012A (en) *	1975-10-14	1977-01-18	Sterling Drug Inc.	3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones

1980
- 1980-03-28 US US06/135,100 patent/US4297360A/en not_active Expired - Lifetime
- 1980-11-06 US US06/204,726 patent/US4312875A/en not_active Expired - Lifetime
1981
- 1981-03-17 IL IL62401A patent/IL62401A/xx unknown
- 1981-03-24 NL NL8101453A patent/NL8101453A/nl not_active Application Discontinuation
- 1981-03-24 GB GB8109260A patent/GB2073185B/en not_active Expired
- 1981-03-25 FI FI810920A patent/FI810920L/fi not_active Application Discontinuation
- 1981-03-26 DK DK136781A patent/DK136781A/da not_active Application Discontinuation
- 1981-03-26 ZA ZA00812026A patent/ZA812026B/xx unknown
- 1981-03-26 NO NO811040A patent/NO811040L/no unknown
- 1981-03-26 PT PT72743A patent/PT72743B/pt unknown
- 1981-03-26 BE BE1/10187A patent/BE888122A/fr not_active IP Right Cessation
- 1981-03-26 FR FR8106071A patent/FR2479224A1/fr active Granted
- 1981-03-26 ES ES500726A patent/ES500726A0/es active Granted
- 1981-03-27 KR KR1019810001014A patent/KR830005201A/ko unknown
- 1981-03-27 SE SE8101993A patent/SE8101993L/xx not_active Application Discontinuation
- 1981-03-27 JP JP4533581A patent/JPS56150064A/ja active Pending
- 1981-03-27 IT IT20785/81A patent/IT1136973B/it active
- 1981-03-27 CA CA000374044A patent/CA1171856A/fr not_active Expired
- 1981-03-27 PH PH25441A patent/PH22271A/en unknown
- 1981-03-27 NZ NZ196641A patent/NZ196641A/en unknown
- 1981-03-27 AT AT0143781A patent/ATA143781A/de not_active Application Discontinuation
- 1981-03-27 DE DE19813112251 patent/DE3112251A1/de not_active Withdrawn
- 1981-03-27 AU AU68836/81A patent/AU545667B2/en not_active Ceased
- 1981-03-27 IE IE700/81A patent/IE52712B1/en unknown
- 1981-03-27 LU LU83258A patent/LU83258A1/fr unknown
- 1981-10-07 FR FR8118887A patent/FR2490644B1/fr not_active Expired
1985
- 1985-03-08 SE SE8501169A patent/SE8501169D0/xx unknown

Also Published As

Publication number	Publication date
FR2479224A1 (fr)	1981-10-02
IL62401A0 (en)	1981-05-20
ES8202816A1 (es)	1982-03-01
PT72743A (en)	1981-04-01
IT1136973B (it)	1986-09-03
IT8120785A0 (it)	1981-03-27
PT72743B (en)	1982-03-24
SE8101993L (sv)	1981-11-13
FR2490644A1 (fr)	1982-03-26
AU6883681A (en)	1981-10-08
NZ196641A (en)	1984-03-16
DK136781A (da)	1981-09-29
DE3112251A1 (de)	1982-04-01
IE810700L (en)	1981-09-28
NL8101453A (nl)	1981-10-16
FR2490644B1 (fr)	1984-12-14
KR830005201A (ko)	1983-08-03
ES500726A0 (es)	1982-03-01
NO811040L (no)	1981-09-28
IL62401A (en)	1985-01-31
AU545667B2 (en)	1985-07-25
ATA143781A (de)	1986-02-15
GB2073185A (en)	1981-10-14
IE52712B1 (en)	1988-02-03
FR2479224B1 (fr)	1984-12-14
ZA812026B (en)	1982-04-28
US4297360A (en)	1981-10-27
US4312875A (en)	1982-01-26
BE888122A (fr)	1981-09-28
LU83258A1 (fr)	1981-10-29
JPS56150064A (en)	1981-11-20
CA1171856A (fr)	1984-07-31
SE8501169D0 (sv)	1985-03-08
GB2073185B (en)	1984-02-29
FI810920L (fi)	1981-09-29

Publication	Publication Date	Title
PH22271A (en)	1988-07-14	5-(pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
IL64220A0 (en)	1982-02-28	Nicotinamide derivatives,their preparation and their use as herbicides
HK31189A (en)	1989-04-21	5-(pyridinyl)-2(1h)-pyridinones,useful as cardiotonic agents and their preparation
JPS5711966A (en)	1982-01-21	Pyridoxine derivative,manufacture and medicinal use
IL64854A0 (en)	1982-03-31	Sulfonylurea n-oxides and their use as herbicides
EG13630A (en)	1982-09-30	4-(5-trifluoromethyl-2-pyridyloxy)phenoxyalkane derivatives and herbicides containing the same
IL66645A0 (en)	1982-12-31	Pyridine and pyrazine derivatives,their manufacture and their use as fungicides
NZ193904A (en)	1981-11-19	Phenoxypyridine derivatives and herbicidal compositions
ZA801345B (en)	1981-04-29	3-substituted pyridine derivatives,processes for their preparation and their use as fungicides
IL61841A (en)	1984-03-30	Triazolylphenacyl pyridyl ether derivatives,their preparation and their use as fungicides
AU518910B2 (en)	1981-10-29	2.3.5.6-tetrachloropyridine and pentachloropyridine
IL65338A (en)	1985-06-30	3-(2-benzyl-1,3-dioxolan-2-yl)-pyridine derivatives,their manufacture and their use as fungicides
JPS5724364A (en)	1982-02-08	2-(2-imidazoline-2-yl)pyridines and quinolines, manufacture and intermediate and herbicidal use
PT71539A (en)	1980-08-01	Process for the preparation of 1,2-dihydro-2-oxo-5-(pyridinyl) nicotinonitrile
GB1534477A (en)	1978-12-06	Oximecarbamates and their use as insecticides,acaricides and nematicides
PH19458A (en)	1986-04-18	2-alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof
GB2089791B (en)	1984-08-30	1,2-dihydro-5-(pyridinyl) nicotinamide derivatives and their preparation
ZA803679B (en)	1981-06-24	5-(4-pyridinyl)-2(lh) pyridinones, useful as cardiotonic agents, and their preparation
ZA813474B (en)	1982-06-30	Cardiotonic aminophenylpyridine derivatives and preparation
PH16014A (en)	1983-05-20	6-(pyridinyl)-4-substituted-3(2h)-pyridazinones,useful as cardiotonic agents and pharmaceutical preparation
AU6515780A (en)	1981-06-18	6-(pyridinyl) pyridazines and preparation
ZA807267B (en)	1981-11-25	5-(pyridinyl)-2(1h)-pyridinones,useful as cardiotonic agents and their preparation
GB2093019B (en)	1985-02-20	Nicotinic acid derivatives and preparations thereof
ZA815165B (en)	1982-08-25	Substituted triazolylalkyl pyridyl ethers,processes for their preparation and their use as fungicides
PH16741A (en)	1984-02-10	5-(pyridinyl)-6-alkyl-2-(1h)-pyridinones and use as cardiotonics