ES500726A0 - Un procedimiento para preparar diaminopiridinas - Google Patents

Un procedimiento para preparar diaminopiridinas

Info

Publication number: ES500726A0
Authority: ES; Spain
Prior art keywords: diaminopyridids; preparing; procedure; preparing diaminopyridids
Prior art date: 1980-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES500726A

Other languages

English (en)

Other versions

ES8202816A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

STWB Inc

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-28

Filing date

1981-03-26

Publication date

1982-03-01

1981-03-26 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1982-03-01 Publication of ES8202816A1 publication Critical patent/ES8202816A1/es

1982-03-01 Publication of ES500726A0 publication Critical patent/ES500726A0/es

Status Granted legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES500726A 1980-03-28 1981-03-26 Un procedimiento para preparar diaminopiridinas Granted ES500726A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/135,100 US4297360A (en)	1980-03-28	1980-03-28	5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use

Publications (2)

Publication Number	Publication Date
ES8202816A1 ES8202816A1 (es)	1982-03-01
ES500726A0 true ES500726A0 (es)	1982-03-01

Family

ID=22466542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES500726A Granted ES500726A0 (es)	1980-03-28	1981-03-26	Un procedimiento para preparar diaminopiridinas

Country Status (24)

Country	Link
US (2)	US4297360A (es)
JP (1)	JPS56150064A (es)
KR (1)	KR830005201A (es)
AT (1)	ATA143781A (es)
AU (1)	AU545667B2 (es)
BE (1)	BE888122A (es)
CA (1)	CA1171856A (es)
DE (1)	DE3112251A1 (es)
DK (1)	DK136781A (es)
ES (1)	ES500726A0 (es)
FI (1)	FI810920L (es)
FR (2)	FR2479224A1 (es)
GB (1)	GB2073185B (es)
IE (1)	IE52712B1 (es)
IL (1)	IL62401A (es)
IT (1)	IT1136973B (es)
LU (1)	LU83258A1 (es)
NL (1)	NL8101453A (es)
NO (1)	NO811040L (es)
NZ (1)	NZ196641A (es)
PH (1)	PH22271A (es)
PT (1)	PT72743B (es)
SE (2)	SE8101993L (es)
ZA (1)	ZA812026B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4420617A (en) *	1980-03-28	1983-12-13	Sterling Drug Inc.	5(Pyridinyl)pyridin-2-amines
US4351941A (en) *	1981-02-04	1982-09-28	Sterling Drug Inc.	Pyridinyl-pyridines
US4374141A (en) *	1981-08-17	1983-02-15	Sterling Drug Inc.	2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use
US4361569A (en) *	1981-08-26	1982-11-30	Sterling Drug Inc.	3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof
US4465686A (en) *	1981-09-08	1984-08-14	Sterling Drug Inc.	5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
US4599423A (en) *	1982-04-26	1986-07-08	Sterling Drug Inc.	Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones
US4595762A (en) *	1982-08-25	1986-06-17	Sterling Drug Inc.	5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles
US4469699A (en) *	1982-08-25	1984-09-04	Sterling Drug Inc.	5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use
US4539327A (en) *	1982-08-25	1985-09-03	Sterling Drug Inc.	5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof
US4448780A (en) *	1982-09-03	1984-05-15	Sterling Drug Inc.	N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof
US4463008A (en) *	1982-11-10	1984-07-31	Sterling Drug Inc.	2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof
US4431651A (en) *	1982-11-18	1984-02-14	Sterling Drug Inc.	2-Pyridinones and their use as cardiotonic agents
US4451469A (en) *	1982-12-16	1984-05-29	Sterling Drug Inc.	Selected 6-alkyl-and 4,6-dialkyl-2(1H)-pyridinones as cardiotonics
US4517192A (en) *	1983-01-31	1985-05-14	Sterling Drug Inc.	6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics
IL74373A0 (en) *	1984-02-21	1985-05-31	Lilly Co Eli	Process for the preparation of diaminopyridines
EP0200024B1 (de)	1985-04-30	1992-07-01	ARZNEIMITTELWERK DRESDEN GmbH	3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US4895867A (en) *	1986-06-26	1990-01-23	Norwich Eaton Pharmaceuticals, Inc.	2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents
US4882354A (en) *	1987-12-16	1989-11-21	Norwich Eaton Pharmaceuticals, Inc.	N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
EP0326307B1 (en) *	1988-01-23	1994-08-17	Kyowa Hakko Kogyo Co., Ltd.	Novel pyridazinone derivatives and pharmaceutical preparations containing them
WO1992003451A1 (en) *	1990-08-21	1992-03-05	The Upjohn Company	Bisphosphonic acid derivatives as anti-arthritic agents
CZ403592A3 (en) *	1992-02-20	1993-12-15	Hoechst Ag	Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
EP0615825B1 (de) *	1993-03-14	1998-11-04	WILHELM HEDRICH VAKUUMANLAGEN GmbH & Co. KG	Verfahren und Vorrichtung zum Füllen von Giessformen mit Giessharz o. dgl. giessfähig flüssigen Medien
US8263585B2 (en)	2007-05-04	2012-09-11	Novartis Ag	Organic compounds
US8268834B2 (en)	2008-03-19	2012-09-18	Novartis Ag	Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
JP6191883B2 (ja)	2011-08-16	2017-09-06	カーディオラピーティーワイリミテッド	制御放出製剤
CN107530337B (zh)	2014-12-22	2021-07-09	贝克心脏与糖尿病研究所	治疗方法
CN106243032A (zh) *	2016-07-20	2016-12-21	扬子江药业集团江苏海慈生物药业有限公司	一种米力农的制备方法
CN111377857B (zh) *	2018-12-30	2023-04-18	鲁南制药集团股份有限公司	一种米力农的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1322318A (en) *	1971-05-19	1973-07-04	Sterling Drug Inc	1-alkyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and esters
US3838156A (en) *	1973-03-29	1974-09-24	Sterling Drug Inc	Certain 2-substituted-6-(3 or 4-pyridyl)-nicotinic acid derivatives
US4004012A (en) *	1975-10-14	1977-01-18	Sterling Drug Inc.	3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones

1980
- 1980-03-28 US US06/135,100 patent/US4297360A/en not_active Expired - Lifetime
- 1980-11-06 US US06/204,726 patent/US4312875A/en not_active Expired - Lifetime
1981
- 1981-03-17 IL IL62401A patent/IL62401A/xx unknown
- 1981-03-24 NL NL8101453A patent/NL8101453A/nl not_active Application Discontinuation
- 1981-03-24 GB GB8109260A patent/GB2073185B/en not_active Expired
- 1981-03-25 FI FI810920A patent/FI810920L/fi not_active Application Discontinuation
- 1981-03-26 DK DK136781A patent/DK136781A/da not_active Application Discontinuation
- 1981-03-26 ZA ZA00812026A patent/ZA812026B/xx unknown
- 1981-03-26 NO NO811040A patent/NO811040L/no unknown
- 1981-03-26 PT PT72743A patent/PT72743B/pt unknown
- 1981-03-26 BE BE1/10187A patent/BE888122A/fr not_active IP Right Cessation
- 1981-03-26 FR FR8106071A patent/FR2479224A1/fr active Granted
- 1981-03-26 ES ES500726A patent/ES500726A0/es active Granted
- 1981-03-27 KR KR1019810001014A patent/KR830005201A/ko unknown
- 1981-03-27 SE SE8101993A patent/SE8101993L/xx not_active Application Discontinuation
- 1981-03-27 JP JP4533581A patent/JPS56150064A/ja active Pending
- 1981-03-27 IT IT20785/81A patent/IT1136973B/it active
- 1981-03-27 CA CA000374044A patent/CA1171856A/en not_active Expired
- 1981-03-27 PH PH25441A patent/PH22271A/en unknown
- 1981-03-27 NZ NZ196641A patent/NZ196641A/en unknown
- 1981-03-27 AT AT0143781A patent/ATA143781A/de not_active Application Discontinuation
- 1981-03-27 DE DE19813112251 patent/DE3112251A1/de not_active Withdrawn
- 1981-03-27 AU AU68836/81A patent/AU545667B2/en not_active Ceased
- 1981-03-27 IE IE700/81A patent/IE52712B1/en unknown
- 1981-03-27 LU LU83258A patent/LU83258A1/fr unknown
- 1981-10-07 FR FR8118887A patent/FR2490644B1/fr not_active Expired
1985
- 1985-03-08 SE SE8501169A patent/SE8501169D0/xx unknown

Also Published As

Publication number	Publication date
FR2479224A1 (fr)	1981-10-02
IL62401A0 (en)	1981-05-20
ES8202816A1 (es)	1982-03-01
PT72743A (en)	1981-04-01
IT1136973B (it)	1986-09-03
IT8120785A0 (it)	1981-03-27
PT72743B (en)	1982-03-24
SE8101993L (sv)	1981-11-13
FR2490644A1 (es)	1982-03-26
AU6883681A (en)	1981-10-08
NZ196641A (en)	1984-03-16
DK136781A (da)	1981-09-29
DE3112251A1 (de)	1982-04-01
IE810700L (en)	1981-09-28
NL8101453A (nl)	1981-10-16
FR2490644B1 (es)	1984-12-14
KR830005201A (ko)	1983-08-03
NO811040L (no)	1981-09-28
IL62401A (en)	1985-01-31
AU545667B2 (en)	1985-07-25
ATA143781A (de)	1986-02-15
GB2073185A (en)	1981-10-14
PH22271A (en)	1988-07-14
IE52712B1 (en)	1988-02-03
FR2479224B1 (es)	1984-12-14
ZA812026B (en)	1982-04-28
US4297360A (en)	1981-10-27
US4312875A (en)	1982-01-26
BE888122A (fr)	1981-09-28
LU83258A1 (fr)	1981-10-29
JPS56150064A (en)	1981-11-20
CA1171856A (en)	1984-07-31
SE8501169D0 (sv)	1985-03-08
GB2073185B (en)	1984-02-29
FI810920L (fi)	1981-09-29

Publication	Publication Date	Title
ES500726A0 (es)	1982-03-01	Un procedimiento para preparar diaminopiridinas
ES502565A0 (es)	1983-11-01	Un procedimiento para preparar derivados de tetralina
ES493061A0 (es)	1981-06-16	Un procedimiento para preparar un lipopolisacarido
ES490166A0 (es)	1981-04-01	Un procedimiento para preparar mercaptoacildipeptidos
ES500727A0 (es)	1982-01-16	Un procedimiento para preparar imidazo-piridinas
ES534694A0 (es)	1985-11-01	Un procedimiento para preparar cefuroxima sodica
ES523195A0 (es)	1984-10-01	Un procedimiento para preparar alquil-glicosidos
ES537668A0 (es)	1985-09-16	Un procedimiento para preparar n-formil-3-fenoxi-1-azetidincarboxamidas
AR231299A1 (es)	1984-10-31	Un procedimiento para preparar copolimeros
ES503134A0 (es)	1982-11-01	Un procedimiento para preparar nuevos compuestos de cefem
ES497303A0 (es)	1982-01-01	Un procedimiento para preparar 9-aminoalquilfluorenos
ES523193A0 (es)	1984-10-01	Un procedimiento para preparar 3-fenoxi-1-azetidincarbo-xznmidas
ES531550A0 (es)	1985-12-01	Procedimiento para preparar un fenilaminobencoalcanol
ES505498A0 (es)	1982-09-16	Un procedimiento para preparar nuevos compuestos de cefem
ES494459A0 (es)	1981-08-16	Un procedimiento para preparar cetoximinoeteres
ES518758A0 (es)	1984-03-01	Un procedimiento para preparar azetidinas.
ES534170A0 (es)	1985-12-16	Un procedimiento para preparar 1-piridil-alquil-4-aril-piperazinas
ES505656A0 (es)	1982-12-01	Un procedimiento para preparar nuevos derivados de antraci- clina
ES500412A0 (es)	1982-01-16	Un procedimiento para preparar una pirazolopiridina
ES524772A0 (es)	1985-06-01	Un procedimiento para preparar fenilanilinas-n.sustituidas.
ES500464A0 (es)	1982-02-01	Un procedimiento para preparar 2-halogeno-acetanilidas
ES500776A0 (es)	1982-01-01	Un procedimiento para preparar un adhesivo
ES506302A0 (es)	1982-08-16	Un procedimiento para preparar derivados de tetrahidroiso- quinoleinas
ES527108A0 (es)	1985-07-01	Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas
ES493191A0 (es)	1981-06-16	Un metodo para preparar feniliminotiadiazolinas