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PE20210548A1 - Derivado de amino-fluoropiperidina como inhibidor de quinasa - Google Patents

Derivado de amino-fluoropiperidina como inhibidor de quinasa

Info

Publication number
PE20210548A1
PE20210548A1 PE2020000773A PE2020000773A PE20210548A1 PE 20210548 A1 PE20210548 A1 PE 20210548A1 PE 2020000773 A PE2020000773 A PE 2020000773A PE 2020000773 A PE2020000773 A PE 2020000773A PE 20210548 A1 PE20210548 A1 PE 20210548A1
Authority
PE
Peru
Prior art keywords
amino
kinase inhibitor
fluoropiperidine
derivative
fluoropiperidine derivative
Prior art date
Application number
PE2020000773A
Other languages
English (en)
Inventor
In Woo Kim
Nam Youn Kim
Seung Hwarn Jeong
Jun Hee Lee
Original Assignee
Dae Woong Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma filed Critical Dae Woong Pharma
Publication of PE20210548A1 publication Critical patent/PE20210548A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a un compuesto representado por la Formula 1 donde R1 es C1-5 alquil, halogeno, ciano; X es N-R2, O, S; R2 es C1-5 alquil, C1-5 haloalquil, C3-6 cicloalquil. El compuesto segun la presente invencion puede usarse de manera util para la prevencion o el tratamiento de enfermedades que estan asociadas con acciones inhibidoras de quinasas.
PE2020000773A 2017-12-28 2018-12-28 Derivado de amino-fluoropiperidina como inhibidor de quinasa PE20210548A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170183060A KR102577241B1 (ko) 2017-12-28 2017-12-28 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체
PCT/KR2018/016812 WO2019132560A1 (ko) 2017-12-28 2018-12-28 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체

Publications (1)

Publication Number Publication Date
PE20210548A1 true PE20210548A1 (es) 2021-03-17

Family

ID=67063980

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000773A PE20210548A1 (es) 2017-12-28 2018-12-28 Derivado de amino-fluoropiperidina como inhibidor de quinasa

Country Status (22)

Country Link
US (1) US11078206B2 (es)
EP (1) EP3733671B1 (es)
JP (1) JP7032535B2 (es)
KR (1) KR102577241B1 (es)
CN (1) CN111491934B (es)
AU (1) AU2018394995B2 (es)
BR (1) BR112020013164A2 (es)
CA (1) CA3084777C (es)
CL (1) CL2020001754A1 (es)
DO (1) DOP2020000109A (es)
EC (1) ECSP20035222A (es)
ES (1) ES2923682T3 (es)
MA (1) MA51429A (es)
MX (1) MX2020006708A (es)
MY (1) MY196186A (es)
PE (1) PE20210548A1 (es)
PH (1) PH12020551014A1 (es)
RU (1) RU2762637C1 (es)
SA (1) SA520412333B1 (es)
SG (1) SG11202004918XA (es)
TN (1) TN2020000125A1 (es)
WO (1) WO2019132560A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104263816B (zh) 2008-05-16 2018-10-19 生命技术公司 用于测量细胞增殖的双标记法
CA3069990A1 (en) 2017-08-01 2019-02-07 Theravance Biopharma R&D Ip, Llc Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors
KR102577242B1 (ko) 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체
WO2019132562A1 (ko) 2017-12-28 2019-07-04 주식회사 대웅제약 카이네이즈 저해제로서의 옥시-플루오로피페리딘 유도체
CA3125039A1 (en) 2019-01-23 2020-07-30 Theravance Biopharma R&D Ip, Llc Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors
US11814373B2 (en) 2019-09-23 2023-11-14 Pmv Pharmaceuticals, Inc. Methods and compounds for restoring mutant p53 function
CN114901659A (zh) 2019-11-26 2022-08-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的稠合嘧啶吡啶酮化合物
CN115244055B (zh) * 2020-01-21 2024-09-03 江苏先声药业有限公司 嘧啶并五元环类衍生物及其应用
WO2021147952A1 (zh) * 2020-01-21 2021-07-29 江苏先声药业有限公司 嘧啶并吡咯类化合物
CN116096704A (zh) 2020-06-24 2023-05-09 皮姆维制药公司 用于治疗癌症的组合疗法
WO2022062601A1 (zh) * 2020-09-22 2022-03-31 江苏先声药业有限公司 嘧啶并吡咯类化合物
CN114315838B (zh) * 2020-09-30 2024-09-03 江苏先声药业有限公司 嘧啶并吡咯类化合物
IL314122A (en) 2022-01-27 2024-09-01 Pmv Pharmaceuticals Inc Deuterium-converted compounds to restore mutant P53 activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
JP5369183B2 (ja) 2008-07-16 2013-12-18 ファーマサイクリックス,インク. 固形腫瘍の治療用のブルートンのチロシンキナーゼの阻害剤
KR101705158B1 (ko) * 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Egfr 억제제 및 질환 치료방법
UA111272C2 (uk) * 2010-06-23 2016-04-11 Ханмі Сайєнс Ко., Лтд. Конденсовані піримідинові похідні для інгібування тирозинкіназної активності
CA2847540C (en) 2011-09-22 2016-05-17 Pfizer Inc. Pyrrolopyrimidine and purine derivatives
HUE031955T2 (en) * 2012-08-06 2017-08-28 Acea Biosciences Inc New pyrrole pyrimidine compounds as inhibitors of protein kinases
BR112016005881A2 (pt) 2013-09-18 2017-09-12 Beijing Hanmi Pharmaceutical Co Ltd composto, composição farmacêutica e uso do composto
PT3318565T (pt) * 2013-12-05 2021-05-28 Pfizer Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo e pirrolo[2,3-d]piridinilo acrilamidas
CN105732637B (zh) * 2014-12-30 2020-04-21 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
CN108934162A (zh) * 2015-12-16 2018-12-04 南方研究所 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法
MY191110A (en) 2016-06-30 2022-05-30 Daewoong Pharmaceutical Co Ltd Pyrazolopyrimidine derivatives as kinase inhibitor
KR102032418B1 (ko) 2017-06-15 2019-10-16 한국화학연구원 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물

Also Published As

Publication number Publication date
MA51429A (fr) 2021-04-07
CA3084777A1 (en) 2019-07-04
EP3733671A4 (en) 2021-06-09
EP3733671A1 (en) 2020-11-04
NZ765159A (en) 2023-09-29
SG11202004918XA (en) 2020-06-29
BR112020013164A2 (pt) 2020-12-01
US20200299298A1 (en) 2020-09-24
CN111491934A (zh) 2020-08-04
TN2020000125A1 (en) 2022-01-06
ECSP20035222A (es) 2020-07-31
MX2020006708A (es) 2020-08-20
KR102577241B1 (ko) 2023-09-11
CA3084777C (en) 2022-08-30
CN111491934B (zh) 2022-08-30
ES2923682T3 (es) 2022-09-29
WO2019132560A1 (ko) 2019-07-04
AU2018394995B2 (en) 2021-05-13
DOP2020000109A (es) 2020-09-30
US11078206B2 (en) 2021-08-03
AU2018394995A1 (en) 2020-06-25
SA520412333B1 (ar) 2022-12-08
CL2020001754A1 (es) 2020-11-27
JP2021505644A (ja) 2021-02-18
RU2762637C1 (ru) 2021-12-21
KR20190080540A (ko) 2019-07-08
EP3733671B1 (en) 2022-06-29
JP7032535B2 (ja) 2022-03-08
MY196186A (en) 2023-03-21
PH12020551014A1 (en) 2021-08-16

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