PE20210548A1 - Derivado de amino-fluoropiperidina como inhibidor de quinasa - Google Patents
Derivado de amino-fluoropiperidina como inhibidor de quinasaInfo
- Publication number
- PE20210548A1 PE20210548A1 PE2020000773A PE2020000773A PE20210548A1 PE 20210548 A1 PE20210548 A1 PE 20210548A1 PE 2020000773 A PE2020000773 A PE 2020000773A PE 2020000773 A PE2020000773 A PE 2020000773A PE 20210548 A1 PE20210548 A1 PE 20210548A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- kinase inhibitor
- fluoropiperidine
- derivative
- fluoropiperidine derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a un compuesto representado por la Formula 1 donde R1 es C1-5 alquil, halogeno, ciano; X es N-R2, O, S; R2 es C1-5 alquil, C1-5 haloalquil, C3-6 cicloalquil. El compuesto segun la presente invencion puede usarse de manera util para la prevencion o el tratamiento de enfermedades que estan asociadas con acciones inhibidoras de quinasas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170183060A KR102577241B1 (ko) | 2017-12-28 | 2017-12-28 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
PCT/KR2018/016812 WO2019132560A1 (ko) | 2017-12-28 | 2018-12-28 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20210548A1 true PE20210548A1 (es) | 2021-03-17 |
Family
ID=67063980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000773A PE20210548A1 (es) | 2017-12-28 | 2018-12-28 | Derivado de amino-fluoropiperidina como inhibidor de quinasa |
Country Status (22)
Country | Link |
---|---|
US (1) | US11078206B2 (es) |
EP (1) | EP3733671B1 (es) |
JP (1) | JP7032535B2 (es) |
KR (1) | KR102577241B1 (es) |
CN (1) | CN111491934B (es) |
AU (1) | AU2018394995B2 (es) |
BR (1) | BR112020013164A2 (es) |
CA (1) | CA3084777C (es) |
CL (1) | CL2020001754A1 (es) |
DO (1) | DOP2020000109A (es) |
EC (1) | ECSP20035222A (es) |
ES (1) | ES2923682T3 (es) |
MA (1) | MA51429A (es) |
MX (1) | MX2020006708A (es) |
MY (1) | MY196186A (es) |
PE (1) | PE20210548A1 (es) |
PH (1) | PH12020551014A1 (es) |
RU (1) | RU2762637C1 (es) |
SA (1) | SA520412333B1 (es) |
SG (1) | SG11202004918XA (es) |
TN (1) | TN2020000125A1 (es) |
WO (1) | WO2019132560A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104263816B (zh) | 2008-05-16 | 2018-10-19 | 生命技术公司 | 用于测量细胞增殖的双标记法 |
CA3069990A1 (en) | 2017-08-01 | 2019-02-07 | Theravance Biopharma R&D Ip, Llc | Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors |
KR102577242B1 (ko) | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
WO2019132562A1 (ko) | 2017-12-28 | 2019-07-04 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 옥시-플루오로피페리딘 유도체 |
CA3125039A1 (en) | 2019-01-23 | 2020-07-30 | Theravance Biopharma R&D Ip, Llc | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
US11814373B2 (en) | 2019-09-23 | 2023-11-14 | Pmv Pharmaceuticals, Inc. | Methods and compounds for restoring mutant p53 function |
CN114901659A (zh) | 2019-11-26 | 2022-08-12 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的稠合嘧啶吡啶酮化合物 |
CN115244055B (zh) * | 2020-01-21 | 2024-09-03 | 江苏先声药业有限公司 | 嘧啶并五元环类衍生物及其应用 |
WO2021147952A1 (zh) * | 2020-01-21 | 2021-07-29 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
CN116096704A (zh) | 2020-06-24 | 2023-05-09 | 皮姆维制药公司 | 用于治疗癌症的组合疗法 |
WO2022062601A1 (zh) * | 2020-09-22 | 2022-03-31 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
CN114315838B (zh) * | 2020-09-30 | 2024-09-03 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
IL314122A (en) | 2022-01-27 | 2024-09-01 | Pmv Pharmaceuticals Inc | Deuterium-converted compounds to restore mutant P53 activity |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
JP5369183B2 (ja) | 2008-07-16 | 2013-12-18 | ファーマサイクリックス,インク. | 固形腫瘍の治療用のブルートンのチロシンキナーゼの阻害剤 |
KR101705158B1 (ko) * | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
UA111272C2 (uk) * | 2010-06-23 | 2016-04-11 | Ханмі Сайєнс Ко., Лтд. | Конденсовані піримідинові похідні для інгібування тирозинкіназної активності |
CA2847540C (en) | 2011-09-22 | 2016-05-17 | Pfizer Inc. | Pyrrolopyrimidine and purine derivatives |
HUE031955T2 (en) * | 2012-08-06 | 2017-08-28 | Acea Biosciences Inc | New pyrrole pyrimidine compounds as inhibitors of protein kinases |
BR112016005881A2 (pt) | 2013-09-18 | 2017-09-12 | Beijing Hanmi Pharmaceutical Co Ltd | composto, composição farmacêutica e uso do composto |
PT3318565T (pt) * | 2013-12-05 | 2021-05-28 | Pfizer | Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo e pirrolo[2,3-d]piridinilo acrilamidas |
CN105732637B (zh) * | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
CN108934162A (zh) * | 2015-12-16 | 2018-12-04 | 南方研究所 | 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法 |
MY191110A (en) | 2016-06-30 | 2022-05-30 | Daewoong Pharmaceutical Co Ltd | Pyrazolopyrimidine derivatives as kinase inhibitor |
KR102032418B1 (ko) | 2017-06-15 | 2019-10-16 | 한국화학연구원 | 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
-
2017
- 2017-12-28 KR KR1020170183060A patent/KR102577241B1/ko active IP Right Grant
-
2018
- 2018-12-28 MX MX2020006708A patent/MX2020006708A/es unknown
- 2018-12-28 CA CA3084777A patent/CA3084777C/en active Active
- 2018-12-28 JP JP2020532550A patent/JP7032535B2/ja active Active
- 2018-12-28 AU AU2018394995A patent/AU2018394995B2/en active Active
- 2018-12-28 TN TNP/2020/000125A patent/TN2020000125A1/en unknown
- 2018-12-28 RU RU2020124577A patent/RU2762637C1/ru active
- 2018-12-28 ES ES18894845T patent/ES2923682T3/es active Active
- 2018-12-28 PE PE2020000773A patent/PE20210548A1/es unknown
- 2018-12-28 CN CN201880081900.XA patent/CN111491934B/zh active Active
- 2018-12-28 SG SG11202004918XA patent/SG11202004918XA/en unknown
- 2018-12-28 EP EP18894845.9A patent/EP3733671B1/en active Active
- 2018-12-28 MA MA051429A patent/MA51429A/fr unknown
- 2018-12-28 MY MYPI2020002995A patent/MY196186A/en unknown
- 2018-12-28 WO PCT/KR2018/016812 patent/WO2019132560A1/ko active Application Filing
- 2018-12-28 US US16/770,642 patent/US11078206B2/en active Active
- 2018-12-28 BR BR112020013164-4A patent/BR112020013164A2/pt unknown
-
2020
- 2020-06-10 DO DO2020000109A patent/DOP2020000109A/es unknown
- 2020-06-25 SA SA520412333A patent/SA520412333B1/ar unknown
- 2020-06-26 EC ECSENADI202035222A patent/ECSP20035222A/es unknown
- 2020-06-26 CL CL2020001754A patent/CL2020001754A1/es unknown
- 2020-06-28 PH PH12020551014A patent/PH12020551014A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
MA51429A (fr) | 2021-04-07 |
CA3084777A1 (en) | 2019-07-04 |
EP3733671A4 (en) | 2021-06-09 |
EP3733671A1 (en) | 2020-11-04 |
NZ765159A (en) | 2023-09-29 |
SG11202004918XA (en) | 2020-06-29 |
BR112020013164A2 (pt) | 2020-12-01 |
US20200299298A1 (en) | 2020-09-24 |
CN111491934A (zh) | 2020-08-04 |
TN2020000125A1 (en) | 2022-01-06 |
ECSP20035222A (es) | 2020-07-31 |
MX2020006708A (es) | 2020-08-20 |
KR102577241B1 (ko) | 2023-09-11 |
CA3084777C (en) | 2022-08-30 |
CN111491934B (zh) | 2022-08-30 |
ES2923682T3 (es) | 2022-09-29 |
WO2019132560A1 (ko) | 2019-07-04 |
AU2018394995B2 (en) | 2021-05-13 |
DOP2020000109A (es) | 2020-09-30 |
US11078206B2 (en) | 2021-08-03 |
AU2018394995A1 (en) | 2020-06-25 |
SA520412333B1 (ar) | 2022-12-08 |
CL2020001754A1 (es) | 2020-11-27 |
JP2021505644A (ja) | 2021-02-18 |
RU2762637C1 (ru) | 2021-12-21 |
KR20190080540A (ko) | 2019-07-08 |
EP3733671B1 (en) | 2022-06-29 |
JP7032535B2 (ja) | 2022-03-08 |
MY196186A (en) | 2023-03-21 |
PH12020551014A1 (en) | 2021-08-16 |
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