[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PE20081779A1 - Derivados de nicotinamida - Google Patents

Derivados de nicotinamida

Info

Publication number
PE20081779A1
PE20081779A1 PE2008000378A PE2008000378A PE20081779A1 PE 20081779 A1 PE20081779 A1 PE 20081779A1 PE 2008000378 A PE2008000378 A PE 2008000378A PE 2008000378 A PE2008000378 A PE 2008000378A PE 20081779 A1 PE20081779 A1 PE 20081779A1
Authority
PE
Peru
Prior art keywords
pyrimidin
carboxamide
fluorophenyl
compounds
refers
Prior art date
Application number
PE2008000378A
Other languages
English (en)
Inventor
Kirk Lang Olson
Tanisha Danielle Rowe Blake
Matthew James Pelc
Steve R Turner
John I Trujillo
Atli Thorarensen
Barbara Ann Schweitzer
Jr James Richard Kiefer
Wei Huang
Bradley E Neal
Joseph Blair Moon
Bruce Cameron Hamper
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20081779A1 publication Critical patent/PE20081779A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE NICOTINAMIDA DE FORMULA (Ia) DONDE R1, R3 Y R4 SON CADA UNO H, F, CHF2, OH, CH2OH, CN, ENTRE OTROS; R2 ES H O F; R5 ES H, NH2, OH O CH3; L ES C(O)NH, NHC(O) O CH2NHC(O); A ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-(2-(3-FLUOROFENIL)PIRIMIDIN-5-CARBOXAMIDO)PIRROLIDIN-1-CARBOXILATO DE ETILO, 2-(3-FLUOROFENIL)-N-{1-[(METILAMINO)CARBONIL]PIPERIDIN-4-IL}PIRIMIDIN-5-CARBOXAMIDA, 2-(3-FLUOROFENIL)-N-[1-(6-METIL-5,6,7,8-TETRAHIDROPIRIDO[4,3-d]PIRIMIDIN-2-IL)PIRROLIDIN-3-IL]PIRIMIDIN-5-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROSTAGLANDINA SINTASA DE TIPO HEMATOPOYETICA (H-PGDS) SIENDO UTILES EN EL TRATAMIENTO DE RINITIS ALERGICA, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, DERMATITIS ATOPICA
PE2008000378A 2007-02-26 2008-02-25 Derivados de nicotinamida PE20081779A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89165007P 2007-02-26 2007-02-26

Publications (1)

Publication Number Publication Date
PE20081779A1 true PE20081779A1 (es) 2008-12-18

Family

ID=39529670

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000378A PE20081779A1 (es) 2007-02-26 2008-02-25 Derivados de nicotinamida

Country Status (10)

Country Link
US (2) US7582643B2 (es)
EP (1) EP2132196A1 (es)
JP (1) JP2010519328A (es)
AR (1) AR065464A1 (es)
CA (1) CA2679198C (es)
CL (1) CL2008000585A1 (es)
PE (1) PE20081779A1 (es)
TW (1) TW200845998A (es)
UY (1) UY30938A1 (es)
WO (1) WO2008104869A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522524A (ja) 2008-05-13 2011-08-04 ケイマン ケミカル カンパニー 化合物又は製剤における造血プロスタグランジンｄシンターゼの有力リガンドを置換する能力をアッセイする方法
JP2011524894A (ja) 2008-06-18 2011-09-08 ファイザー・リミテッド ニコチンアミド誘導体
NZ592297A (en) * 2008-09-22 2012-11-30 Cayman Chemical Co Inc 2-Aryl-5-heteroaryl pyridine and pyrimidine derivatives as pharmaceutical active agents
WO2011044307A1 (en) * 2009-10-08 2011-04-14 Sanofi-Aventis Phenyloxadiazole derivatives as pgds inhibitors
ES2617339T3 (es) 2010-12-16 2017-06-16 Calchan Limited Derivados de pirrolopirimidina inhibidores de ASK1
WO2014066568A1 (en) 2012-10-24 2014-05-01 Winthrop-University Hospital Non-invasive biomarker to identify subjects at risk of preterm delivery
CN103601722B (zh) * 2013-09-13 2016-03-02 南京华威医药科技开发有限公司 新型抗肿瘤化合物
EP3682250A4 (en) 2017-09-13 2021-03-03 Progenity, Inc. PRECLAMPSY BIOMARKERS AND RELATED SYSTEMS AND PROCEDURES
MX2021014441A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
KR20220030222A (ko) 2019-05-31 2022-03-10 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
CN111549000B (zh) * 2020-06-18 2022-07-29 中国医学科学院整形外科医院 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用
KR20230027059A (ko) 2020-06-19 2023-02-27 사토 세이야쿠 가부시키가이샤 H－pgds를 저해하는 축환 화합물
WO2023113023A1 (ja) 2021-12-17 2023-06-22 佐藤製薬株式会社 Ｈ－ｐｇｄｓを阻害するアザインドール誘導体

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2230894A1 (en) 1995-09-01 1997-03-13 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
EP0891361A1 (en) 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
IL136637A0 (en) 1997-12-22 2001-06-14 Du Pont Pharm Co Nitrogen containing heteroaromatics with ortho-substituted pi's as factor xa inhibitors
MXPA02003167A (es) 1999-09-28 2003-10-06 Eisai Co Ltd Compuestos de quinuclidina, y farmacos que contienen los mismos a manera del ingrediente activo.
PL372944A1 (en) 2001-02-20 2005-08-08 Bristol-Myers Squibb Company 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators
EP1429765A2 (en) 2001-09-14 2004-06-23 Methylgene, Inc. Inhibitors of histone deacetylase
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
JP4500483B2 (ja) 2002-03-25 2010-07-14 独立行政法人科学技術振興機構 ヒト由来プロスタグランジン合成酵素阻害剤
US20050222235A1 (en) 2002-07-12 2005-10-06 Yoshihiro Urade Drugs for improving the prognosis of brain injury and a method of screening the same
JP4550353B2 (ja) 2002-07-24 2010-09-22 株式会社医薬分子設計研究所 造血器型プロスタグランジンｄ２合成酵素阻害剤
WO2004031180A1 (ja) 2002-10-03 2004-04-15 Institute Of Medicinal Molecular Design. Inc. キナゾリン−４−オン誘導体
EP1575918A2 (en) * 2002-12-19 2005-09-21 Neurogen Corporation Substituted biaryl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
ES2257616T3 (es) * 2003-04-25 2006-08-01 Actimis Pharmaceuticals, Inc. Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2.
EP1638955A2 (en) 2003-07-02 2006-03-29 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
WO2005028624A2 (en) 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
WO2005040135A1 (ja) 2003-10-24 2005-05-06 Ono Pharmaceutical Co., Ltd. 抗ストレス薬およびその医薬用途
US20050165028A1 (en) 2004-01-23 2005-07-28 Norman Mark H. Vanilloid receptor ligands and their use in treatments
WO2005094805A1 (ja) 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
TW200720255A (en) 2005-07-13 2007-06-01 Taiho Pharmaceutical Co Ltd Benzoimidazole compound capable of inhibiting prostaglandin d synthetase
PE20070589A1 (es) * 2005-10-04 2007-06-22 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
GB0520657D0 (en) 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
WO2007048042A2 (en) 2005-10-21 2007-04-26 University Of Alabama At Birmingham Small molecule inhibitors of hiv-1 capsid assembly
CA2672373C (en) 2006-12-19 2011-08-30 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases

Also Published As

Publication number Publication date
EP2132196A1 (en) 2009-12-16
JP2010519328A (ja) 2010-06-03
US20080207651A1 (en) 2008-08-28
US7582643B2 (en) 2009-09-01
CL2008000585A1 (es) 2008-08-29
UY30938A1 (es) 2008-09-30
CA2679198C (en) 2011-07-12
US8067589B2 (en) 2011-11-29
AR065464A1 (es) 2009-06-10
CA2679198A1 (en) 2008-09-04
TW200845998A (en) 2008-12-01
US20090281125A1 (en) 2009-11-12
WO2008104869A1 (en) 2008-09-04

Similar Documents

Publication Publication Date Title
PE20081779A1 (es) Derivados de nicotinamida
PE20081385A1 (es) Derivados de nicotinamida
MY151172A (en) Pyrimidine amide compounds as pgds inhibitors
MY154895A (en) Pyrimidine hydrazide compounds as pgds inhibitors
MD4574B1 (ro) 3,5-Diamino-6-cloro-N-(N-(4-(4-(2-(hexil (2,3,4,5,6-pentahidroxihexil) amino) etoxi) fenil) butil) carbamimidoil)pirazină-2-carboxamidă
PH12014500947B1 (en) 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
MX2009010270A (es) Indol carboxamidas como inhibidores de quinasas ikappa2.
SG155932A1 (en) Chemical compounds
NO20091590L (no) Heterocykliske amidforbindelser anvendbare som kinaseinhibitorer
UA115881C2 (uk) Алкоксипіразоли як активатори розчинної гуанілатциклази
PE20090288A1 (es) Derivados de quinoxalina como inhibidores de la pi3 quinasa
EA201071019A1 (ru) Кристаллические формы производных фениламинопиримидина
MX2010005824A (es) Derivados de aminotiazol.
NO20071137L (no) Nye piperidinderivater for behandling av depresjon
NO20063597L (no) Acetylinske piperazinforbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister
UA99699C2 (ru) Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит
TW200616967A (en) Novel indazole carboxamides and their use
NO20084674L (no) 1- [ (4-(benzoyl (metyl) amino] -3- (fenyl) butyl] azetidinderivater for behandling av gastrointestinale lidelser
IL206615A0 (en) Piperidine sulfonamide derivatives
WO2008089436A3 (en) Crystalline forms of histone deacetylase inhibitors
WO2010122580A3 (en) Piperidine derivatives as inhibitors of renin
WO2012085935A3 (en) Diamide piperidine compounds as inhibitors of renin
TH100707B (th) กระบวนการสำหรับการเตรียมผลิตภัณฑ์ของสารประกอบเบนซิมิดาซอล ไธเอนิลเอมีน และอนุพันธ์ของมัน ซึ่งเป็นประโยชน์ในการใช้เป็นสารยับยั้งการแลกเปลี่ยนโซเดียม/โปรตอน รูปแบบที่3

Legal Events

Date Code Title Description
FD Application declared void or lapsed