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PE20021155A1 - Derivados de quinolina como antagonistas de neuropeptidos y - Google Patents

Derivados de quinolina como antagonistas de neuropeptidos y

Info

Publication number
PE20021155A1
PE20021155A1 PE2002000425A PE2002000425A PE20021155A1 PE 20021155 A1 PE20021155 A1 PE 20021155A1 PE 2002000425 A PE2002000425 A PE 2002000425A PE 2002000425 A PE2002000425 A PE 2002000425A PE 20021155 A1 PE20021155 A1 PE 20021155A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxy
pyrrolidin
methyl
quinoline
Prior art date
Application number
PE2002000425A
Other languages
English (en)
Inventor
Werner Mueller
Jean-Marc Plancher
Philippe Pflieger
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20021155A1 publication Critical patent/PE20021155A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DERIVADOS DE QUINOLINA DE FORMULA I DONDE R1 ES H, ALQUILO, ALCOXIALQUILO, ALQUENILO, ALQUINILO, HIDROXIALQUILO, ARALQUILO, HETEROCICLILALQUILO, CICLOALQUILALQUILO, NH2SO2, ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO, ALQUENILO, ALQUINILO, ARALQUILO, HETEROARILALQUILO, ALCOXI, ALCOXIALCOXI, ENTRE OTROS; R3 ES H, ALQUILO, NH2, MONOALQUILAMINO, DIALQUILAMINO, ALCOXI; R4 ES H, ALQUILO, CICLOALQUILO, ALCOXI, OH, NH2, ALQUIL-SO2, ENTRE OTROS; R5 ES H, ALQUILO, CICLOALQUILO, ALCOXI, HIDROXI, NH2, ALQUILAMINO, ENTRE OTROS; A ES UN ANILLO HETEROCICLICO DE 5-10 MIEMBROS. SON COMPUESTOS PREFERIDOS 7-CICLOPROPILMETOXI-2-METIL-4-PIRROLIDIN-1-IL-QUINOLINA; 6-BUTIL-4-PIRROLIDIN-1-IL-QUINOLIN-7-OL; 2-METIL-4-PIRROLIDIN-1-IL-QUINOLIN-7-OL; 7-(3-METOXI-BENCILOXI)-2-METIL-4-PIRROLIDIN-1-IL-QUINOLINA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y AL USO DE LOS COMPUESTOS CON INHIBIDORES DE LIPASA COMO ORLISTAT. LOS COMPUESTOS SON ANTAGONISTAS DE RECEPTORES DE NEUROPEPTIDOS Y, PUEDEN SER UTILES PARA EL TRATAMIENTO DE ARTRITIS, DIABETES, TRASTORNOS DE COMIDA, OBESIDAD
PE2002000425A 2001-05-21 2002-05-17 Derivados de quinolina como antagonistas de neuropeptidos y PE20021155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01112370 2001-05-21

Publications (1)

Publication Number Publication Date
PE20021155A1 true PE20021155A1 (es) 2002-12-17

Family

ID=8177497

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000425A PE20021155A1 (es) 2001-05-21 2002-05-17 Derivados de quinolina como antagonistas de neuropeptidos y

Country Status (19)

Country Link
US (2) US6818767B2 (es)
EP (1) EP1395564B1 (es)
JP (1) JP3715280B2 (es)
KR (1) KR100621287B1 (es)
CN (1) CN100376557C (es)
AR (1) AR035979A1 (es)
AT (1) ATE387428T1 (es)
AU (1) AU2002338896B2 (es)
BR (1) BR0209957A (es)
CA (1) CA2446324A1 (es)
DE (1) DE60225274T2 (es)
ES (1) ES2300478T3 (es)
GT (1) GT200200090A (es)
MX (1) MXPA03010565A (es)
PA (1) PA8545301A1 (es)
PE (1) PE20021155A1 (es)
UY (1) UY27300A1 (es)
WO (1) WO2002094789A1 (es)
ZA (1) ZA200308783B (es)

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Also Published As

Publication number Publication date
ATE387428T1 (de) 2008-03-15
PA8545301A1 (es) 2003-01-24
AR035979A1 (es) 2004-07-28
KR100621287B1 (ko) 2006-09-13
UY27300A1 (es) 2002-11-29
US6818767B2 (en) 2004-11-16
GT200200090A (es) 2003-06-19
MXPA03010565A (es) 2004-03-02
ZA200308783B (en) 2005-02-11
WO2002094789A1 (en) 2002-11-28
ES2300478T3 (es) 2008-06-16
CN100376557C (zh) 2008-03-26
JP2004536066A (ja) 2004-12-02
US20050049413A1 (en) 2005-03-03
DE60225274D1 (de) 2008-04-10
CA2446324A1 (en) 2002-11-28
US20020198194A1 (en) 2002-12-26
KR20030096416A (ko) 2003-12-24
DE60225274T2 (de) 2009-03-26
EP1395564A1 (en) 2004-03-10
AU2002338896B2 (en) 2006-04-27
JP3715280B2 (ja) 2005-11-09
CN1522249A (zh) 2004-08-18
EP1395564B1 (en) 2008-02-27
BR0209957A (pt) 2004-03-30

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