PE133599A1 - Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacion - Google Patents
Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacionInfo
- Publication number
- PE133599A1 PE133599A1 PE1998001189A PE00118998A PE133599A1 PE 133599 A1 PE133599 A1 PE 133599A1 PE 1998001189 A PE1998001189 A PE 1998001189A PE 00118998 A PE00118998 A PE 00118998A PE 133599 A1 PE133599 A1 PE 133599A1
- Authority
- PE
- Peru
- Prior art keywords
- alkynyl
- alkyl
- cholesterol
- alkylene
- refers
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 8
- 235000012000 cholesterol Nutrition 0.000 abstract 4
- -1 DIMETHYLAMINOMETHYL Chemical class 0.000 abstract 2
- 206010020740 Hyperproteinaemia Diseases 0.000 abstract 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 1
- 229940107161 cholesterol Drugs 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/14—Dithiocarbamic acids; Derivatives thereof
- C07C333/18—Esters of dithiocarbamic acids
- C07C333/24—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A URETANOS DE FORMULA I DONDE: m ES 0-1; n ES 1-2; A ES ENLACE, ALQUILENO C1-C8, ALQUENILENO C2-C8, ALQUINILENO C2-C8, NO ESTA UNIDO A "Y" UN GRUPO INSATURADO; X ES O o S; Y ES O o S; R1 ES ALQUILO C1-C8, ALQUENILO C1-C6, ALQUINILO C1-C6; R2 ES H, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON HIDROXI o ALCOXI; o R1 Y R2 JUNTO A N FORMAN UN ANILLO HETEROCICLICO DE 5-7 MIEMBROS; R3 A R6 SON H o ALQUILO; R7 ES ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6; R8 ES CICLOALQUILO C3-C7, FENILO, NAFTILO OPCIONALMENTE SUSTITUIDO, SI A NO ES UN ENLACE, ENTONCES ES H. UN COMPUESTO PREFERIDO ES TRANS-S-(4-CLOROFENIL)-N-4-[4-(DIMETILAMINOMETIL)FENIL]-CICLOHEXIL-N-METILDITIOCARBAMATO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS SUSTANCIAS ACTIVAS CON ACTIVIDAD REDUCTORA DEL COLESTEROL O LIPIDOS COMO RESINAS FIJADORAS DE ACIDOS BILIARES, COMPUESTOS QUE INHIBEN LA RESORCION DE COLESTEROL, FIBRATOS, ACIDO NICOTINICO. EL COMPUESTO I INHIBE A 2,3-EPOXIESCUALENO-LANOSTEROL-CICLASA QUE INTERVIENE EN LA BIOSINTESIS DEL COLESTEROL Y PUEDE SER UTIL PARA EL TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERPROTEINEMIA, HIPERTRIGLICERIDEMIA, ATEROSCLEROSIS, MICOSIS; TAMBIEN SE LE EMPLEA COMO PIENSO PARA LAS GALLINAS PONEDORAS PARA PRODUCIR HUEVOS POBRES EN COLESTEROL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19754795A DE19754795A1 (de) | 1997-12-10 | 1997-12-10 | Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE133599A1 true PE133599A1 (es) | 2000-01-13 |
Family
ID=7851380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001189A PE133599A1 (es) | 1997-12-10 | 1998-12-07 | Nuevos uretanos, sus analogos tio y ditio, sus sales, medicamentos que contienen estos compuestos y su empleo asi como procedimientos para su preparacion |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6346545B1 (es) |
| EP (1) | EP1045832B1 (es) |
| JP (1) | JP4001317B2 (es) |
| KR (1) | KR20010024708A (es) |
| CN (1) | CN1281431A (es) |
| AR (1) | AR014405A1 (es) |
| AT (1) | ATE291570T1 (es) |
| AU (1) | AU747173B2 (es) |
| BG (1) | BG104501A (es) |
| BR (1) | BR9813545A (es) |
| CA (1) | CA2310055C (es) |
| CO (1) | CO5290251A1 (es) |
| CZ (1) | CZ20002150A3 (es) |
| DE (2) | DE19754795A1 (es) |
| EA (1) | EA003298B1 (es) |
| EE (1) | EE200000340A (es) |
| HR (1) | HRP980621A2 (es) |
| HU (1) | HUP0100292A3 (es) |
| ID (1) | ID21432A (es) |
| IL (1) | IL135737A0 (es) |
| NO (1) | NO20002968L (es) |
| NZ (1) | NZ505594A (es) |
| PE (1) | PE133599A1 (es) |
| PL (1) | PL341654A1 (es) |
| SK (1) | SK8602000A3 (es) |
| TR (1) | TR200001636T2 (es) |
| UY (1) | UY25288A1 (es) |
| WO (1) | WO1999029662A2 (es) |
| YU (1) | YU35500A (es) |
| ZA (1) | ZA9811263B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011512388A (ja) * | 2008-02-22 | 2011-04-21 | ビーエーエスエフ ソシエタス・ヨーロピア | ３’−ブロモ−２，３，４，６’−テトラメトキシ−２’，６−ジメチルベンゾフェノンを含んでいる殺菌剤組成物 |
| US10143686B2 (en) * | 2010-12-27 | 2018-12-04 | The Curators Of The University Of Missouri | Oxidosqualene cyclase as a protein target for anticancer therapeutics |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
| US5011859A (en) * | 1990-03-30 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase |
| CA2047375C (en) * | 1990-07-25 | 2003-04-15 | Charlotte L. Barney | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
| US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
| DE4303840A1 (de) * | 1992-10-22 | 1994-08-11 | Thomae Gmbh Dr K | Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| US5466687A (en) | 1992-10-22 | 1995-11-14 | Dr. Karl Thomae Gmbh | Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation |
| DE4239150A1 (de) | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4239151A1 (de) | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4438020A1 (de) * | 1994-10-25 | 1996-05-02 | Thomae Gmbh Dr K | N-substituierte Arylcyclohexylacylamine, ihre Salze mit physiologisch verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel |
-
1997
- 1997-12-10 DE DE19754795A patent/DE19754795A1/de not_active Withdrawn
-
1998
- 1998-12-07 PE PE1998001189A patent/PE133599A1/es not_active Application Discontinuation
- 1998-12-07 UY UY25288A patent/UY25288A1/es unknown
- 1998-12-07 ID IDP981585A patent/ID21432A/id unknown
- 1998-12-08 BR BR9813545-7A patent/BR9813545A/pt not_active IP Right Cessation
- 1998-12-08 WO PCT/EP1998/007962 patent/WO1999029662A2/de active IP Right Grant
- 1998-12-08 KR KR1020007006319A patent/KR20010024708A/ko not_active Withdrawn
- 1998-12-08 CN CN98811960A patent/CN1281431A/zh active Pending
- 1998-12-08 CA CA002310055A patent/CA2310055C/en not_active Expired - Fee Related
- 1998-12-08 PL PL98341654A patent/PL341654A1/xx not_active Application Discontinuation
- 1998-12-08 TR TR2000/01636T patent/TR200001636T2/xx unknown
- 1998-12-08 EA EA200000633A patent/EA003298B1/ru not_active IP Right Cessation
- 1998-12-08 JP JP2000524259A patent/JP4001317B2/ja not_active Expired - Fee Related
- 1998-12-08 AU AU17593/99A patent/AU747173B2/en not_active Ceased
- 1998-12-08 HU HU0100292A patent/HUP0100292A3/hu unknown
- 1998-12-08 DE DE59812686T patent/DE59812686D1/de not_active Expired - Lifetime
- 1998-12-08 EE EEP200000340A patent/EE200000340A/xx unknown
- 1998-12-08 SK SK860-2000A patent/SK8602000A3/sk unknown
- 1998-12-08 IL IL13573798A patent/IL135737A0/xx unknown
- 1998-12-08 YU YU35500A patent/YU35500A/sh unknown
- 1998-12-08 NZ NZ505594A patent/NZ505594A/en unknown
- 1998-12-08 EP EP98962422A patent/EP1045832B1/de not_active Expired - Lifetime
- 1998-12-08 CZ CZ20002150A patent/CZ20002150A3/cs unknown
- 1998-12-08 AT AT98962422T patent/ATE291570T1/de not_active IP Right Cessation
- 1998-12-09 CO CO98073124A patent/CO5290251A1/es not_active Application Discontinuation
- 1998-12-09 HR HR19754795.8A patent/HRP980621A2/hr not_active Application Discontinuation
- 1998-12-09 ZA ZA9811263A patent/ZA9811263B/xx unknown
- 1998-12-09 AR ARP980106227A patent/AR014405A1/es not_active Withdrawn
-
1999
- 1999-03-24 US US09/275,318 patent/US6346545B1/en not_active Expired - Lifetime
-
2000
- 2000-06-02 BG BG104501A patent/BG104501A/bg active Pending
- 2000-06-09 NO NO20002968A patent/NO20002968L/no not_active Application Discontinuation
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| SE8100403L (sv) | Cyklohexen-derivat | |
| AR027578A1 (es) | Derivados de indano |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |