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PA8591601A1 - Agonistas morfolinicos de la dopamina - Google Patents

Agonistas morfolinicos de la dopamina

Info

Publication number
PA8591601A1
PA8591601A1 PA20038591601A PA8591601A PA8591601A1 PA 8591601 A1 PA8591601 A1 PA 8591601A1 PA 20038591601 A PA20038591601 A PA 20038591601A PA 8591601 A PA8591601 A PA 8591601A PA 8591601 A1 PA8591601 A1 PA 8591601A1
Authority
PA
Panama
Prior art keywords
morpholinic
dopamine
agonists
rent
compound
Prior art date
Application number
PA20038591601A
Other languages
English (en)
Inventor
Allerton Charlotte Moria Norfor
Andrew Douglas Baxter
Andrew Simon Cook
David Hepworth
Wong Stephen Kwok-Fung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0228787A external-priority patent/GB0228787D0/en
Priority claimed from GB0308460A external-priority patent/GB0308460D0/en
Priority claimed from GB0313606A external-priority patent/GB0313606D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PA8591601A1 publication Critical patent/PA8591601A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA COMPUESTOS DE LAS FORMULAS (I), (lA) Y (lB) EN LAS QUE: A SE SELECCIONA ENTRE C-X Y N, B SE SELECCIONA ENTRE C-Y Y N, R1 SE SELECCIONA ENTRE H Y AQUILO C1-C6, R2 SE SELECCIONA ENTRE H Y ALQUILO C1-C6, X SE SELECCIONA ENTRE H, HO, C(O)NH2, NH2, Y SE SELECCIONA ENTRE H, HO, NH2, Br, Cl Y F, Z SE SELECCIONA ENTRE H, HO, F, CONH2 Y CN; Y SUS SALES, SOLVATOS Y PROFARMACOS FARMACEUTICAMENTE ACEPTABLES; CON LAS CONDICIONES DE QUE: PARA UN COMPUESTO DE LA FORMULA (l), (lA) O (lB), CUANDO A ES C-X, B ES C-Y, R1 ES HO ALQUILO C1,-C61 Y R2 ES H O ALQUILO C11-C6, AL MENOS UNO DE X, Y Y Z DEBE SER OH; PARA UN COMPUESTO DE LA FORMULA (l), CUANDO A ES C-X Y B ES C-Y, Y ES H, Z ES H, R1 ES H, Y R2 ES H, ENTONCES X NO PUEDE SER OH. Y ESTOS COMPUESTROS SON UTILES COMO MEDICAMENTOS.
PA20038591601A 2002-12-10 2003-12-10 Agonistas morfolinicos de la dopamina PA8591601A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0228787A GB0228787D0 (en) 2002-12-10 2002-12-10 Morpholine dopamine agonists
GB0308460A GB0308460D0 (en) 2003-04-11 2003-04-11 Morpholine dopamine agonists
GB0313606A GB0313606D0 (en) 2003-06-12 2003-06-12 Morpholine dopamine agonists

Publications (1)

Publication Number Publication Date
PA8591601A1 true PA8591601A1 (es) 2004-12-16

Family

ID=32512061

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038591601A PA8591601A1 (es) 2002-12-10 2003-12-10 Agonistas morfolinicos de la dopamina

Country Status (37)

Country Link
EP (1) EP1572214B1 (es)
JP (3) JP3889775B2 (es)
KR (1) KR100796102B1 (es)
AP (1) AP2005003325A0 (es)
AR (1) AR042339A1 (es)
AT (1) ATE460938T1 (es)
AU (1) AU2003302878B2 (es)
CA (1) CA2508262C (es)
CO (1) CO5700781A2 (es)
CR (1) CR7869A (es)
CY (1) CY1110130T1 (es)
DE (1) DE60331769D1 (es)
DK (1) DK1572214T3 (es)
EA (1) EA009589B1 (es)
EC (1) ECSP055850A (es)
ES (1) ES2339767T3 (es)
GE (1) GEP20074272B (es)
HK (1) HK1081850A1 (es)
HN (1) HN2003000401A (es)
HR (1) HRP20050523A2 (es)
IS (1) IS7843A (es)
MA (1) MA27605A1 (es)
MX (1) MXPA05006151A (es)
MY (1) MY144338A (es)
NL (1) NL1024983C2 (es)
NO (1) NO330143B1 (es)
NZ (1) NZ540505A (es)
OA (1) OA13014A (es)
PA (1) PA8591601A1 (es)
PE (1) PE20040906A1 (es)
PL (1) PL377480A1 (es)
PT (1) PT1572214E (es)
RS (1) RS51442B (es)
SI (1) SI1572214T1 (es)
TW (1) TW200423944A (es)
UY (1) UY28117A1 (es)
WO (1) WO2004052372A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200601985A1 (ru) * 2004-05-26 2007-04-27 Пфайзер Лимитед Новые производные индазола и индолона и их применение в качестве фармацевтических средств
EP1758862A1 (en) * 2004-05-27 2007-03-07 Pfizer Limited Aminopyridine derivatives as selective dopamine d3 agonists
GB0502509D0 (en) * 2005-02-07 2005-03-16 Pfizer Ltd Novel salt form of a dopamine agonist
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
GB0700786D0 (en) * 2007-01-15 2007-02-21 Pfizer Ltd Morpholine dopamine agonists for the treatment of pain
JP5952267B2 (ja) 2010-05-21 2016-07-13 リサーチ・トライアングル・インスティチュート 薬物依存を処置するためのヒドロキシブプロピオン類似体(政府支援研究または開発)
WO2011146850A1 (en) * 2010-05-21 2011-11-24 Research Triangle Institute Phenylmorpholines and analogues thereof
KR20160097291A (ko) * 2013-12-11 2016-08-17 에프. 호프만-라 로슈 아게 키랄 2-아릴 모폴린의 제조 방법
GB2543296A (en) * 2015-10-13 2017-04-19 Indivior Uk Ltd Dopamine D3 receptor antagonists having a morpholine moiety
EP3725768A1 (en) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB851311A (en) * 1958-04-02 1960-10-12 Geigy Ag J R Morpholine compounds and their production
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction

Also Published As

Publication number Publication date
EA200500801A1 (ru) 2005-12-29
GEP20074272B (en) 2007-12-25
TW200423944A (en) 2004-11-16
IS7843A (is) 2005-05-12
ES2339767T3 (es) 2010-05-25
CY1110130T1 (el) 2015-01-14
RS51442B (en) 2011-04-30
HK1081850A1 (en) 2006-05-26
AR042339A1 (es) 2005-06-15
AU2003302878A1 (en) 2004-06-30
MY144338A (en) 2011-08-29
EP1572214A1 (en) 2005-09-14
CO5700781A2 (es) 2006-11-30
MXPA05006151A (es) 2005-08-26
JP3889775B2 (ja) 2007-03-07
KR20050094813A (ko) 2005-09-28
MA27605A1 (fr) 2005-11-01
RS20050445A (en) 2007-04-10
EA009589B1 (ru) 2008-02-28
JP2006511599A (ja) 2006-04-06
HRP20050523A2 (en) 2005-08-31
WO2004052372A1 (en) 2004-06-24
DK1572214T3 (da) 2010-06-07
NO330143B1 (no) 2011-02-21
SI1572214T1 (sl) 2010-07-30
CA2508262A1 (en) 2004-06-24
CA2508262C (en) 2009-12-01
KR100796102B1 (ko) 2008-01-21
NO20052557L (no) 2005-09-06
PT1572214E (pt) 2010-05-06
PE20040906A1 (es) 2005-01-24
JP4624341B2 (ja) 2011-02-02
NO20052557D0 (no) 2005-05-26
HN2003000401A (es) 2004-11-23
NL1024983A1 (nl) 2004-06-11
EP1572214B1 (en) 2010-03-17
DE60331769D1 (de) 2010-04-29
UY28117A1 (es) 2004-07-30
JP2006232857A (ja) 2006-09-07
NZ540505A (en) 2007-02-23
AU2003302878B2 (en) 2009-04-23
ATE460938T1 (de) 2010-04-15
JP3920908B2 (ja) 2007-05-30
NL1024983C2 (nl) 2005-02-01
OA13014A (en) 2006-11-10
JP2007084575A (ja) 2007-04-05
ECSP055850A (es) 2005-09-20
PL377480A1 (pl) 2006-02-06
AP2005003325A0 (en) 2005-06-30
CR7869A (es) 2005-07-08

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