LV10435B - Azole derivatives, method for their preparation and use - Google Patents
Azole derivatives, method for their preparation and use Download PDFInfo
- Publication number
- LV10435B LV10435B LVP-93-286A LV930286A LV10435B LV 10435 B LV10435 B LV 10435B LV 930286 A LV930286 A LV 930286A LV 10435 B LV10435 B LV 10435B
- Authority
- LV
- Latvia
- Prior art keywords
- alkyl
- hydrogen
- aryl
- alkenyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Cephalosporin Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4100109 | 1991-01-04 | ||
DE4109949 | 1991-03-26 | ||
DE4121229 | 1991-06-27 | ||
SU5010754 RU2104272C1 (ru) | 1991-01-04 | 1992-01-03 | Производные имидазола, способ их получения и фармацевтическая композиция, понижающая кровяное давление |
Publications (2)
Publication Number | Publication Date |
---|---|
LV10435A LV10435A (lv) | 1995-02-20 |
LV10435B true LV10435B (en) | 1995-08-20 |
Family
ID=27202079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-93-286A LV10435B (en) | 1991-01-04 | 1993-05-04 | Azole derivatives, method for their preparation and use |
Country Status (23)
Country | Link |
---|---|
US (1) | US5482957A (fr) |
EP (1) | EP0503162B1 (fr) |
JP (1) | JPH07110854B2 (fr) |
KR (1) | KR920014785A (fr) |
AT (1) | ATE165351T1 (fr) |
AU (1) | AU653760B2 (fr) |
BR (1) | BR9200011A (fr) |
CA (1) | CA2058198A1 (fr) |
CS (1) | CS1092A3 (fr) |
DE (1) | DE59209292D1 (fr) |
DK (1) | DK0503162T3 (fr) |
ES (1) | ES2114874T3 (fr) |
FI (1) | FI920017A (fr) |
HR (1) | HRP940767A2 (fr) |
HU (2) | HUT60249A (fr) |
IE (1) | IE920020A1 (fr) |
IL (1) | IL100568A (fr) |
LV (1) | LV10435B (fr) |
MX (1) | MX9200026A (fr) |
NO (1) | NO301881B1 (fr) |
NZ (1) | NZ241169A (fr) |
PH (1) | PH30954A (fr) |
PL (1) | PL168887B1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2058198A1 (fr) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Procede de preparation et utilisation de derives d'azole |
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
EP0505098A1 (fr) * | 1991-03-19 | 1992-09-23 | Merck & Co. Inc. | Dérivés d'imidazole ayant des groupes fonctionnels acides comme angiotensin II antagonistes |
TW215434B (fr) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
NO304429B1 (no) * | 1992-12-17 | 1998-12-14 | Sankyo Co | Bifenylderivater, farmas°ytisk preparat og deres anvendelse for fremstilling av et medikament for behandling av hypertensjon og hjertesykdom |
TW348175B (en) * | 1993-01-06 | 1998-12-21 | Hoechst Ag | Process for the preparation of biphenyl derivatives |
FR2711367B1 (fr) * | 1993-10-19 | 1995-12-01 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
US5395844A (en) * | 1993-06-10 | 1995-03-07 | The Du Pont Merck Pharmaceutical Company | Imidazole 5-position substituted angiotensin II antagonists |
FR2708612B1 (fr) * | 1993-08-05 | 1996-03-01 | Roussel Uclaf | Nouveaux dérivés bicycliques de l'imidazole, leur procédé de préparation, les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant. |
FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
EP0855392A3 (fr) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Hétérocycles à cinq chaínons contenant des substituants biphénylylsulphoniques, leur procédé de préparation, leur utilisation comme médicament ou agent diagnostique ainsi que médicament les contenant |
DE19802969A1 (de) * | 1998-01-27 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
YU78601A (sh) * | 1999-05-05 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
AU2004268621C1 (en) | 2003-08-29 | 2011-08-18 | Exelixis, Inc. | c-Kit modulators and methods of use |
CA2652162A1 (fr) * | 2006-06-01 | 2007-12-06 | Marcel Gubler | Derives de thiazole |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
US7828840B2 (en) | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
EP2227452A2 (fr) | 2007-11-30 | 2010-09-15 | F. Hoffmann-La Roche AG | Composés de pyridine |
EP2297113A1 (fr) * | 2008-04-29 | 2011-03-23 | Theravance, Inc. | Agents antihypertenseurs à double action |
EP2810951B1 (fr) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
EP3241839B1 (fr) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
TWI545114B (zh) | 2009-09-29 | 2016-08-11 | 施萬生物製藥研發Ip有限責任公司 | 製備聯苯基咪唑化合物之方法 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2968439A2 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
EP4424697A2 (fr) | 2013-06-05 | 2024-09-04 | Bausch Health Ireland Limited | Agonistes ultra-purs de guanylate cyclase c, leur procédé de fabrication et d'utilisation |
GB2605148A (en) * | 2021-03-23 | 2022-09-28 | Vicore Pharma Ab | New compounds |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
US4355044A (en) * | 1980-12-19 | 1982-10-19 | Bernardo Heller | D-Phenylalanine treatment |
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
JPS6323868A (ja) * | 1986-07-11 | 1988-02-01 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | アンギオテンシン2受容体遮断性イミダゾ−ル |
CA1334092C (fr) * | 1986-07-11 | 1995-01-24 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii |
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
CA1338238C (fr) * | 1988-01-07 | 1996-04-09 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
SG52709A1 (en) * | 1989-06-30 | 1998-09-28 | Du Pont | Substituted imidazoles |
KR950009860B1 (ko) * | 1989-06-30 | 1995-08-29 | 이. 아이. 듀퐁 드 네모아 앤드 캄파니 | 융합된 환 아릴 치환된 이미다졸과 약제학적으로 허용되는 이의 염, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물 |
EP0409332A3 (en) * | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
JPH03218371A (ja) * | 1989-08-02 | 1991-09-25 | Takeda Chem Ind Ltd | ピラゾール誘導体 |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
CA2085584C (fr) * | 1990-06-22 | 2003-02-11 | David John Carini | Traitement de l'insuffisance renale chronique a l'aide d'antagonistes de type imidazole du recepteur de l'angiotensine ii |
US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
US5087634A (en) * | 1990-10-31 | 1992-02-11 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
CA2058198A1 (fr) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Procede de preparation et utilisation de derives d'azole |
US5236928A (en) * | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
-
1991
- 1991-12-20 CA CA002058198A patent/CA2058198A1/fr not_active Abandoned
- 1991-12-23 NZ NZ241169A patent/NZ241169A/xx unknown
- 1991-12-31 IL IL10056891A patent/IL100568A/en not_active IP Right Cessation
- 1991-12-31 AU AU90110/91A patent/AU653760B2/en not_active Ceased
-
1992
- 1992-01-01 EP EP91122406A patent/EP0503162B1/fr not_active Expired - Lifetime
- 1992-01-01 ES ES91122406T patent/ES2114874T3/es not_active Expired - Lifetime
- 1992-01-01 DK DK91122406T patent/DK0503162T3/da active
- 1992-01-01 AT AT91122406T patent/ATE165351T1/de not_active IP Right Cessation
- 1992-01-01 DE DE59209292T patent/DE59209292D1/de not_active Expired - Lifetime
- 1992-01-02 FI FI920017A patent/FI920017A/fi unknown
- 1992-01-02 PH PH43726A patent/PH30954A/en unknown
- 1992-01-03 PL PL92293064A patent/PL168887B1/pl unknown
- 1992-01-03 CS CS9210A patent/CS1092A3/cs unknown
- 1992-01-03 NO NO920048A patent/NO301881B1/no unknown
- 1992-01-03 HU HU9200021A patent/HUT60249A/hu unknown
- 1992-01-03 IE IE002092A patent/IE920020A1/en not_active Application Discontinuation
- 1992-01-03 BR BR929200011A patent/BR9200011A/pt not_active Application Discontinuation
- 1992-01-03 MX MX9200026A patent/MX9200026A/es unknown
- 1992-01-04 JP JP4017423A patent/JPH07110854B2/ja not_active Expired - Lifetime
- 1992-01-04 KR KR1019920000019A patent/KR920014785A/ko not_active Application Discontinuation
-
1993
- 1993-05-04 LV LVP-93-286A patent/LV10435B/en unknown
-
1994
- 1994-04-28 US US08/234,591 patent/US5482957A/en not_active Expired - Lifetime
- 1994-10-25 HR HRP-1974/91A patent/HRP940767A2/hr not_active Application Discontinuation
-
1995
- 1995-06-29 HU HU95P/P00597P patent/HU211985A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
EP0503162B1 (fr) | 1998-04-22 |
NO301881B1 (no) | 1997-12-22 |
FI920017A (fi) | 1992-07-05 |
JPH04308587A (ja) | 1992-10-30 |
ATE165351T1 (de) | 1998-05-15 |
IL100568A (en) | 1996-11-14 |
IE920020A1 (en) | 1992-07-15 |
HU211985A9 (en) | 1996-01-29 |
US5482957A (en) | 1996-01-09 |
KR920014785A (ko) | 1992-08-25 |
ES2114874T3 (es) | 1998-06-16 |
JPH07110854B2 (ja) | 1995-11-29 |
FI920017A0 (fi) | 1992-01-02 |
AU9011091A (en) | 1992-07-09 |
DE59209292D1 (de) | 1998-05-28 |
CS1092A3 (en) | 1992-07-15 |
PL293064A1 (en) | 1992-09-21 |
HU9200021D0 (en) | 1992-03-30 |
CA2058198A1 (fr) | 1992-07-05 |
NO920048L (no) | 1992-07-06 |
LV10435A (lv) | 1995-02-20 |
HRP940767A2 (en) | 1997-02-28 |
AU653760B2 (en) | 1994-10-13 |
IL100568A0 (en) | 1992-09-06 |
PH30954A (en) | 1997-12-23 |
MX9200026A (es) | 1992-08-01 |
PL168887B1 (pl) | 1996-04-30 |
BR9200011A (pt) | 1992-09-08 |
EP0503162A1 (fr) | 1992-09-16 |
NO920048D0 (no) | 1992-01-03 |
NZ241169A (en) | 1995-01-27 |
HUT60249A (en) | 1992-08-28 |
DK0503162T3 (da) | 1998-12-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LV10435B (en) | Azole derivatives, method for their preparation and use | |
JP3542813B2 (ja) | ビフェニルスルホニル尿素またはビフェニルスルホニルウレタン側鎖を有するイミダゾール誘導体、その製法およびそれからなる高血圧治療剤 | |
US5183899A (en) | Pyrazole derivative | |
CA2036304C (fr) | Derives de la pyrimidinedione; preparation et utilisation | |
JP3212036B2 (ja) | 置換アゾール、その製造方法およびその含有組成物 | |
AU653288B2 (en) | Sulphonylbenzyl-substituted pyridones | |
SK13195A3 (en) | Imidazole carboxylic acids and pharmaceutical agent containing thereof | |
EP0430300A2 (fr) | Dérivés de xanthine, leur préparation et application | |
EP0443568A1 (fr) | Dérivés fusés de thiophène, leur préparation et leur application | |
PT91426A (pt) | Processo para a preparacao de composicoes farmaceuticas antiviricas incorporando derivados de acido alfa-aminoboronico | |
IE913991A1 (en) | Substituted azoles, process for their preparation, agents¹containing them and their use | |
SK10694A3 (en) | Compounds having angiotensine ii antagonistic activity | |
JPH04225959A (ja) | 複素環式化合物 | |
CA2031916A1 (fr) | Composes de cycloheptimidazolone employes comme antagonistes de l'angiotensine ii pour reduire l'hypertension | |
SK34993A3 (en) | Propenoyl-imidazole derivatives | |
JP3032844B2 (ja) | ピリミジンジオン誘導体 | |
CA2108815A1 (fr) | Pyridinobiphenyles a substituant alkoxymethyl | |
JPH06211814A (ja) | (チオ)ウレア誘導体 | |
JP2837318B2 (ja) | アンジオテンシンii拮抗性ピリジン誘導体 | |
JP3243086B2 (ja) | 4,5,6,7−テトラヒドロ−1H−イミダゾ[4,5−c]ピリジン−6−カルボン酸アミド誘導体 | |
CA2090274A1 (fr) | Imidazoles substitues par un groupement sulfonylbenzyle | |
LT3373B (en) | Azole derivatives, process for preparing and using thereof | |
CA2124057A1 (fr) | 2,4-imidazolidinediones substituees |