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LT2734522T - 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai - Google Patents

4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai

Info

Publication number
LT2734522T
LT2734522T LTEP12733505.7T LT12733505T LT2734522T LT 2734522 T LT2734522 T LT 2734522T LT 12733505 T LT12733505 T LT 12733505T LT 2734522 T LT2734522 T LT 2734522T
Authority
LT
Lithuania
Prior art keywords
benzamides
imidazotriazin
imidazopyridazin
btk
inhibitors
Prior art date
Application number
LTEP12733505.7T
Other languages
English (en)
Inventor
Tjeerd A. Barf
Christiaan Jans
de Adrianus MAN
Arthur A. Oubrie
Hans C.A. Raaijmakers
Johannes Rewinkel
Jan-Gerard Sterrenburg
Jacobus C.H.M. Wijkmans
Original Assignee
Merck Sharp & Dohme B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2734522(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme B.V. filed Critical Merck Sharp & Dohme B.V.
Publication of LT2734522T publication Critical patent/LT2734522T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Biomedical Technology (AREA)
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  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTEP12733505.7T 2011-07-19 2012-07-11 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai LT2734522T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19
PCT/EP2012/063552 WO2013010868A1 (en) 2011-07-19 2012-07-11 4 - imidazopyridazin- 1 -yl-benzamides and 4 - imidazotriazin- 1 - yl - benzamides as btk- inhibitors

Publications (1)

Publication Number Publication Date
LT2734522T true LT2734522T (lt) 2019-02-11

Family

ID=47557677

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12733505.7T LT2734522T (lt) 2011-07-19 2012-07-11 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk-inhibitoriai

Country Status (36)

Country Link
US (7) US9290504B2 (lt)
EP (4) EP3689878B1 (lt)
JP (6) JP5826931B2 (lt)
KR (2) KR101802689B1 (lt)
CN (2) CN106243113B (lt)
AU (4) AU2012285987C1 (lt)
BR (1) BR112014001255B1 (lt)
CA (1) CA2841886C (lt)
CL (1) CL2014000130A1 (lt)
CO (1) CO6940411A2 (lt)
CR (1) CR20140030A (lt)
CY (2) CY2021010I2 (lt)
DK (2) DK3689878T3 (lt)
DO (1) DOP2014000008A (lt)
EA (2) EA037644B1 (lt)
EC (1) ECSP14013217A (lt)
ES (3) ES2904707T3 (lt)
GT (1) GT201400009A (lt)
HR (2) HRP20212021T1 (lt)
HU (3) HUE041987T2 (lt)
IL (3) IL230511B (lt)
IN (1) IN2014CN00408A (lt)
LT (1) LT2734522T (lt)
MA (1) MA35348B1 (lt)
MX (1) MX342983B (lt)
MY (1) MY192354A (lt)
PE (1) PE20141681A1 (lt)
PH (1) PH12017500166B1 (lt)
PL (2) PL2734522T3 (lt)
PT (1) PT3689878T (lt)
RS (2) RS58177B1 (lt)
SG (1) SG10201605913VA (lt)
SI (2) SI3689878T1 (lt)
TN (1) TN2014000027A1 (lt)
UA (1) UA115312C2 (lt)
WO (1) WO2013010868A1 (lt)

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BR112012030625A2 (pt) 2010-06-03 2017-06-27 Pharmacyclics Inc uso de inibidores de tirosina quinase de bruton (btk)
EA025496B1 (ru) 2011-05-17 2016-12-30 Принсипиа Биофарма Инк. Ингибиторы тирозинкиназы
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
WO2013010136A2 (en) 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
MY192354A (en) * 2011-07-19 2022-08-17 Merck Sharp & Dohme 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors
MX2015001081A (es) 2012-07-24 2015-10-14 Pharmacyclics Inc Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).
SI2892900T1 (en) 2012-09-10 2018-01-31 Principia Biopharma Inc. Compounds of pyrazolopyrimidine, as kinase inhibitors
MX2015003874A (es) 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
WO2014055934A2 (en) * 2012-10-04 2014-04-10 University Of Utah Research Foundation Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
EP2948458B1 (en) 2013-01-23 2019-05-01 Merck Sharp & Dohme Corp. Btk inhibitors
WO2014113942A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
SG10201709926VA (en) 2013-05-30 2017-12-28 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
NZ715838A (en) * 2013-07-31 2020-05-29 Merck Patent Gmbh Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
WO2015057992A1 (en) * 2013-10-16 2015-04-23 Izumi Raquel Btk inhibitors for hematopoietic mobilization
KR20160093062A (ko) 2013-12-05 2016-08-05 아세르타 파마. 비.브이. Pi3k 억제제 및 btk 억제제의 치료적 조합
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TN2014000027A1 (en) 2015-07-01
AU2016203837B2 (en) 2018-01-25
IL266894A (en) 2019-07-31
EP4249076A2 (en) 2023-09-27
AU2016203837A1 (en) 2016-06-30
CN106243113A (zh) 2016-12-21
JP6251220B2 (ja) 2017-12-20
EP3495368B1 (en) 2023-05-31
ES2950569T3 (es) 2023-10-11
DOP2014000008A (es) 2014-04-30
NZ620085A (en) 2016-05-27
US20230331729A1 (en) 2023-10-19
KR101702727B1 (ko) 2017-02-06
US20140155385A1 (en) 2014-06-05
EA201490300A1 (ru) 2014-05-30
SG10201605913VA (en) 2016-09-29
US20160151364A1 (en) 2016-06-02
JP6617130B2 (ja) 2019-12-11
RS58177B1 (sr) 2019-03-29
JP2019108395A (ja) 2019-07-04
MY192354A (en) 2022-08-17
ES2904707T3 (es) 2022-04-05
CN103889987A (zh) 2014-06-25
EA201992270A3 (ru) 2020-03-31
SI3689878T1 (sl) 2021-12-31
EA037644B1 (ru) 2021-04-26
EP4249076A3 (en) 2023-11-01
US9758524B2 (en) 2017-09-12
AU2017279778B2 (en) 2019-09-19
PL2734522T3 (pl) 2019-04-30
KR20160117642A (ko) 2016-10-10
AU2012285987C1 (en) 2016-09-08
JP2022088618A (ja) 2022-06-14
ES2708224T3 (es) 2019-04-09
JP2018035184A (ja) 2018-03-08
IL266894B (en) 2022-04-01
JP5826931B2 (ja) 2015-12-02
IL230511A0 (en) 2014-03-31
US20210230166A1 (en) 2021-07-29
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RS62760B1 (sr) 2022-01-31
HUE041987T2 (hu) 2019-06-28

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