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KR970006314A - Polypeptides with Antimicrobial and Antifungal Activity - Google Patents

Polypeptides with Antimicrobial and Antifungal Activity Download PDF

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Publication number
KR970006314A
KR970006314A KR1019950019694A KR19950019694A KR970006314A KR 970006314 A KR970006314 A KR 970006314A KR 1019950019694 A KR1019950019694 A KR 1019950019694A KR 19950019694 A KR19950019694 A KR 19950019694A KR 970006314 A KR970006314 A KR 970006314A
Authority
KR
South Korea
Prior art keywords
antimicrobial
amino acid
polypeptide
absent
polypeptides
Prior art date
Application number
KR1019950019694A
Other languages
Korean (ko)
Inventor
이건형
홍성유
조현숙
이복률
정광희
문홍모
Original Assignee
허영섭
재단법인 목암생명공학 연구소
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 허영섭, 재단법인 목암생명공학 연구소 filed Critical 허영섭
Priority to KR1019950019694A priority Critical patent/KR970006314A/en
Priority to PCT/KR1996/000034 priority patent/WO1997002286A1/en
Priority to AU49571/96A priority patent/AU4957196A/en
Priority to US08/700,449 priority patent/US5889148A/en
Publication of KR970006314A publication Critical patent/KR970006314A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 항균성 및 항진균성 폴리펩타이드에 관한 것이다. 본 발명의 폴리펩타이드는 세균 및 진균류에 대해 우수한 항균활성을 가지며 세포에서도 용혈현상을 나타내지 않았다. 따라서 본 발명의 폴리펩타이드는 항균활성을 가지는 물질로서 의약 및 생활용품의 첨가제로 개발될 수 있을 것이다.The present invention relates to antimicrobial and antifungal polypeptides. The polypeptide of the present invention has excellent antimicrobial activity against bacteria and fungi and did not show hemolysis in cells. Therefore, the polypeptide of the present invention may be developed as an additive of medicine and household goods as a substance having antimicrobial activity.

Description

항균성 및 항진균성 활성을 갖는 폴리펩타이드Polypeptides with Antimicrobial and Antifungal Activity

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

하기식(Ⅰ)로 나타내어지는 항균성 및 항진균성 폴리펩타이드.Antimicrobial and antifungal polypeptide represented by the following formula (I). X1X2X3X4X5V C V C X6(Ⅰ)X 1 X 2 X 3 X 4 X 5 VCVCX 6 (Ⅰ) (X1은 아미노산 잔기 2~4개로 구성된 펩타이드이고, X2는 N, K, V로 구성된 군중에서 선택된 아미노산이며, X3는 없거나 G, P, L, K로 구성된 군중에서 선택된 아미노산이고, X4는 없거나 K이며, X5는 없거나 R이고, R6는 R, L, D로 구성된 군중에서 선택된 어느 하나의 아미노산이다.)(X 1 is a peptide consisting of 2-4 amino acid residues, X 2 is an amino acid selected from the crowd consisting of N, K, V, X 3 is absent or an amino acid selected from the crowd consisting of G, P, L, K, X 4 is absent or K, X 5 is absent or R, and R 6 is any amino acid selected from the group consisting of R, L and D.) 제1항에 있어서, X1은 아미노산 잔기 YC, FC, WS, FYC, KYC, PYC, FKYC, FFYC로 이루어진 군에서 선택된 어느 하나의 펩타이드인 것을 특징으로 하는 항균성 및 항진균성 폴리펩타이드.The antimicrobial and antifungal polypeptide of claim 1, wherein X 1 is any one peptide selected from the group consisting of amino acid residues YC, FC, WS, FYC, KYC, PYC, FKYC, FFYC. 제1항에 있어서, 상기 폴리펩타이드의 씨스테인(C) 잔기가 아미노이소뷰틸린산(aminoisobutylic acid)으로 교체된 것을 특징으로 하는 항균성 및 항진균성 폴리펩타이드.The antimicrobial and antifungal polypeptide of claim 1, wherein the cysteine (C) residue of the polypeptide is replaced with aminoisobutylic acid. 제1항의 항균성 및 항진균성 폴리펩타이드를 생물학적 활성 성분으로 함유하는 항균제 조성물.An antimicrobial composition comprising the antimicrobial and antifungal polypeptide of claim 1 as a biologically active ingredient. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950019694A 1995-07-06 1995-07-06 Polypeptides with Antimicrobial and Antifungal Activity KR970006314A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019950019694A KR970006314A (en) 1995-07-06 1995-07-06 Polypeptides with Antimicrobial and Antifungal Activity
PCT/KR1996/000034 WO1997002286A1 (en) 1995-07-06 1996-03-11 Novel antibiotic peptides
AU49571/96A AU4957196A (en) 1995-07-06 1996-03-11 Novel antibiotic peptides
US08/700,449 US5889148A (en) 1995-07-06 1996-03-11 Antibiotic peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950019694A KR970006314A (en) 1995-07-06 1995-07-06 Polypeptides with Antimicrobial and Antifungal Activity

Publications (1)

Publication Number Publication Date
KR970006314A true KR970006314A (en) 1997-02-19

Family

ID=66526765

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950019694A KR970006314A (en) 1995-07-06 1995-07-06 Polypeptides with Antimicrobial and Antifungal Activity

Country Status (1)

Country Link
KR (1) KR970006314A (en)

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