KR950700293A - 세로토닌작동성의 에르골린 유도체(Serotoninergic ergoline derivatives) - Google Patents

세로토닌작동성의 에르골린 유도체(Serotoninergic ergoline derivatives)

Info

Publication number: KR950700293A
Authority: KR; South Korea
Prior art keywords: serotoninergic; ergoline derivatives; ergoline; derivatives; formula
Prior art date: 1992-12-24

Application number

KR1019940702946A

Other languages

English (en)

Other versions

KR100325274B1 (ko

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-24

Filing date

1994-08-24

Publication date

1995-01-16

1992-12-24 Priority claimed from GB929226967A external-priority patent/GB9226967D0/en

1993-03-19 Priority claimed from GB939305696A external-priority patent/GB9305696D0/en

1993-11-26 Application filed filed Critical

1995-01-16 Publication of KR950700293A publication Critical patent/KR950700293A/ko

2002-08-14 Application granted granted Critical

2002-08-14 Publication of KR100325274B1 publication Critical patent/KR100325274B1/ko

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

KR1019940702946A 1992-12-24 1993-11-26 세로토닌작동성에르골린유도체,이의제조방법및이를포함하는약제학적조성물 KR100325274B1 (ko)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB9226967.9		1992-12-24
GB929226967A GB9226967D0 (en)	1992-12-24	1992-12-24	Serotoninergic ergoline derivatives
GB9305696.8		1993-03-19
GB939305696A GB9305696D0 (en)	1993-03-19	1993-03-19	Scrotoninergic ergoline derivatives
PCT/EP1993/003337 WO1994014806A1 (en)	1992-12-24	1993-11-26	Serotoninergic ergoline derivatives

Publications (2)

Publication Number	Publication Date
KR950700293A true KR950700293A (ko)	1995-01-16
KR100325274B1 KR100325274B1 (ko)	2002-08-14

Family

ID=26302231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019940702946A KR100325274B1 (ko)	1992-12-24	1993-11-26	세로토닌작동성에르골린유도체,이의제조방법및이를포함하는약제학적조성물

Country Status (22)

Country	Link
US (1)	US5430031A (ko)
EP (1)	EP0628042B1 (ko)
JP (1)	JP3337688B2 (ko)
KR (1)	KR100325274B1 (ko)
CN (1)	CN1043230C (ko)
AT (1)	ATE204278T1 (ko)
AU (1)	AU669597B2 (ko)
CA (1)	CA2125288C (ko)
DE (1)	DE69330601T2 (ko)
DK (1)	DK0628042T3 (ko)
ES (1)	ES2162856T3 (ko)
FI (1)	FI943839A (ko)
HU (1)	HU220391B (ko)
IL (1)	IL108085A (ko)
MX (1)	MX9400165A (ko)
NZ (1)	NZ258559A (ko)
PL (1)	PL304893A1 (ko)
PT (1)	PT628042E (ko)
RU (1)	RU2131427C1 (ko)
TW (1)	TW252979B (ko)
UA (1)	UA41880C2 (ko)
WO (1)	WO1994014806A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9407637D0 (en)	1994-04-18	1994-06-08	Erba Carlo Spa	Serotoninergic abeo-ergoline derivatives
CZ200380A3 (cs) *	2000-08-16	2004-01-14	Pharmacia & Upjohn Company	Sloučeniny pro léčbu poruch spojených se závislostmi
EP1685838A1 (en) *	2000-08-16	2006-08-02	Pharmacia & Upjohn Company LLC	Compounds for the treatment of addictive disorders
JP3996897B2 (ja)	2001-06-08	2007-10-24	ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス	ソマトスタチン−ドーパミンキメラ類似体
SI21351A (sl) *	2002-12-17	2004-06-30	LEK farmacevtska dru�ba d.d.	Zdravljenje odvisnosti od psihostimulansov
US9777039B2 (en)	2012-11-01	2017-10-03	Ipsen Pharma S.A.S.	Somatostatin analogs and dimers thereof
TWI523863B (zh)	2012-11-01	2016-03-01	艾普森藥品公司	體抑素－多巴胺嵌合體類似物
CN106866656A (zh) *	2017-02-28	2017-06-20	西南交通大学	一类麦角碱衍生物及其在预防和治疗精神疾病的用途
GB2571696B (en)	2017-10-09	2020-05-27	Compass Pathways Ltd	Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CA3138094A1 (en)	2019-04-17	2020-10-22	Compass Pathfinder Limited	Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2802023A1 (de) *	1977-01-28	1978-08-03	Sandoz Ag	Neue ergotderivate, ihre herstellung und verwendung
US4382940A (en) *	1979-12-06	1983-05-10	Farmitalia Carlo Erba S.P.A.	Ercoline derivatives and therapeutic compositions having CNS affecting activity
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
FI76085C (fi) *	1981-07-21	1988-09-09	Erba Farmitalia	Foerfarande foer framstaellning av ergolinderivat.
CH649300A5 (de) *	1981-08-07	1985-05-15	Sandoz Ag	Ergopeptinderivate, ihre herstellung und verwendung.
YU254782A (en)	1981-12-18	1986-10-31	Schering Ag	Process for making new ergot anilides
DE3309493A1 (de) *	1983-03-14	1984-09-20	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) *	1983-04-28	1987-07-27	Erba Farmitalia	Ergoline derivatives
DE3445784A1 (de) *	1984-12-13	1986-06-26	Schering AG, Berlin und Bergkamen, 1000 Berlin	Verfahren zur herstellung von ergolin-derivaten
GB8501078D0 (en) *	1985-01-16	1985-02-20	Erba Farmitalia	Piperazin-1-yl-ergo-line derivatives
GB8515528D0 (en) *	1985-06-19	1985-07-24	Erba Farmitalia	Ergoline derivatives
DE3533672A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-substituierte ergolinderivate
US4968802A (en) *	1985-10-01	1990-11-06	Eli Lilly And Company	Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
US4939258A (en) *	1985-10-01	1990-07-03	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
DE3535929A1 (de) *	1985-10-04	1987-04-09	Schering Ag	1,2-disubstituierte ergolinderivate
GB8612366D0 (en) *	1986-05-21	1986-06-25	Erba Farmitalia	Ergoline esters
DE3620293A1 (de) *	1986-06-16	1987-12-17	Schering Ag	1-und/oder 2-substituierte ergolinderivate
DE3623438C2 (de) *	1986-07-10	1998-04-09	Schering Ag	In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
US4931447A (en) *	1987-06-15	1990-06-05	Eli Lilly And Company	Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4843703A (en) *	1987-07-07	1989-07-04	Truth Incorporated	Method of assembling a window operator
DE3868866D1 (de) *	1987-11-20	1992-04-09	Erba Carlo Spa	Ergolinderivate mit antiparkinsonwirkung.
DE3824659A1 (de) *	1988-07-15	1990-02-08	Schering Ag	2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln
GB8824744D0 (en) *	1988-10-21	1988-11-30	Erba Carlo Spa	Antiemesis ergoline derivatives
US4902691A (en) *	1988-12-19	1990-02-20	Eli Lilly And Company	Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors
DE3913756A1 (de) *	1989-04-21	1990-10-25	Schering Ag	8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung
ES2083564T3 (es) *	1990-01-25	1996-04-16	Pharmacia Spa	Procedimiento para la preparacion de derivados de ergolina.

1993
- 1993-11-26 PT PT94901903T patent/PT628042E/pt unknown
- 1993-11-26 EP EP94901903A patent/EP0628042B1/en not_active Expired - Lifetime
- 1993-11-26 RU RU94040382A patent/RU2131427C1/ru not_active IP Right Cessation
- 1993-11-26 AU AU56286/94A patent/AU669597B2/en not_active Ceased
- 1993-11-26 DK DK94901903T patent/DK0628042T3/da active
- 1993-11-26 PL PL93304893A patent/PL304893A1/xx unknown
- 1993-11-26 KR KR1019940702946A patent/KR100325274B1/ko not_active IP Right Cessation
- 1993-11-26 NZ NZ258559A patent/NZ258559A/en unknown
- 1993-11-26 WO PCT/EP1993/003337 patent/WO1994014806A1/en active IP Right Grant
- 1993-11-26 UA UA94085718A patent/UA41880C2/uk unknown
- 1993-11-26 ES ES94901903T patent/ES2162856T3/es not_active Expired - Lifetime
- 1993-11-26 TW TW082109975A patent/TW252979B/zh active
- 1993-11-26 CA CA002125288A patent/CA2125288C/en not_active Expired - Fee Related
- 1993-11-26 JP JP51472394A patent/JP3337688B2/ja not_active Expired - Fee Related
- 1993-11-26 AT AT94901903T patent/ATE204278T1/de not_active IP Right Cessation
- 1993-11-26 DE DE69330601T patent/DE69330601T2/de not_active Expired - Fee Related
- 1993-11-26 HU HU9401951A patent/HU220391B/hu not_active IP Right Cessation
- 1993-12-20 IL IL10808593A patent/IL108085A/en not_active IP Right Cessation
- 1993-12-20 US US08/169,177 patent/US5430031A/en not_active Expired - Fee Related
- 1993-12-23 CN CN93112788A patent/CN1043230C/zh not_active Expired - Fee Related
1994
- 1994-01-03 MX MX9400165A patent/MX9400165A/es unknown
- 1994-08-19 FI FI943839A patent/FI943839A/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU669597B2 (en)	1996-06-13
TW252979B (ko)	1995-08-01
PL304893A1 (en)	1995-01-09
ATE204278T1 (de)	2001-09-15
AU5628694A (en)	1994-07-19
RU2131427C1 (ru)	1999-06-10
EP0628042A1 (en)	1994-12-14
FI943839A0 (fi)	1994-08-19
FI943839A (fi)	1994-08-19
DK0628042T3 (da)	2001-11-12
IL108085A (en)	1996-10-16
PT628042E (pt)	2002-01-30
US5430031A (en)	1995-07-04
DE69330601T2 (de)	2002-07-04
RU94040382A (ru)	1996-07-10
KR100325274B1 (ko)	2002-08-14
DE69330601D1 (de)	2001-09-20
HUT68190A (en)	1995-05-29
IL108085A0 (en)	1994-04-12
UA41880C2 (uk)	2001-10-15
CA2125288C (en)	2004-11-23
WO1994014806A1 (en)	1994-07-07
HU9401951D0 (en)	1994-09-28
NZ258559A (en)	1996-07-26
JP3337688B2 (ja)	2002-10-21
MX9400165A (es)	1994-07-29
CN1043230C (zh)	1999-05-05
CN1093087A (zh)	1994-10-05
EP0628042B1 (en)	2001-08-16
HU220391B (hu)	2002-01-28
JPH07504207A (ja)	1995-05-11
ES2162856T3 (es)	2002-01-16
CA2125288A1 (en)	1994-07-07

Publication	Publication Date	Title
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
AU8794291A (en)	1992-05-21	New oxazolopyridine derivatives, processes for preparing these and pharmaceutical compositions containing them
ES2158537T3 (es)	2001-09-01	Derivados de acidos ciclopropilalcanoicos.
NO942953D0 (no)	1994-08-09	11-benzaldoksimestradienderivater, fremgangsmåte for deres fremstilling smat legemddel inneholdende slike
AP9801237A0 (en)	1998-06-30	Quinoline derivatives.
PL295030A1 (en)	1993-05-31	Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
DE69130412D1 (de)	1998-12-03	Pyrazolopyridinverbindung und Verfahren zu ihrer Herstellung
ATE203515T1 (de)	2001-08-15	Meta-substituierte phenylsulphonamidderivate
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
EA200100983A1 (ru)	2002-10-31	Производные 13-метилэритромицина
ES2108129T3 (es)	1997-12-16	Nuevos derivados de pirazina, su preparacion y empleo.
CA2286511A1 (en)	2000-04-09	Novel macrolide derivatives
ES2160602T3 (es)	2001-11-16	Derivados de quinolona y acridinona para el tratamiento de la incontinencia urinaria.
TW360652B (en)	1999-06-11	Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
DK0628042T3 (da)	2001-11-12	Serotoninerge ergolinderivater
AP9801377A0 (en)	2000-04-29	Tricyclic erythromycin derivatives.
ES2027550A6 (es)	1992-06-01	Procedimiento para preparar derivados de glicerol.
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
EA199900688A1 (ru)	2000-04-24	Хиноксалиндионы
HUT60495A (en)	1992-09-28	Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
FI911616A0 (fi)	1991-04-04	Substituerade 3-tia- eller 3-oxa-alkyl -flavoner, foerfarande foer deras framstaellning, deras anvaendning, pao dessa foereningar baserade laekemedel samt mellanprodukter.
GR3020922T3 (en)	1996-12-31	Amide derivatives of 1-amino-octahydropyrido[2,1-c][1,4]oxazine, processes for their preparation and pharmaceutical compositions containing them
FI921681A (fi)	1992-04-14	Menetelmä lääkeaineina käyttökelpoisten 2-(heterosyklyylitio)karbapeneemijohdannaisten valmistamiseksi

Legal Events

Date	Code	Title
1996-12-28	N231	Notification of change of applicant
1998-11-26	A201	Request for examination
1998-11-26	AMND	Amendment
2000-08-29	E902	Notification of reason for refusal
2001-02-23	AMND	Amendment
2001-08-24	E601	Decision to refuse application
2001-09-20	AMND	Amendment
2001-09-20	J201	Request for trial against refusal decision
2001-12-20	B701	Decision to grant
2002-02-06	GRNT	Written decision to grant
2005-02-07	LAPS	Lapse due to unpaid annual fee