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ES2083564T3 - Procedimiento para la preparacion de derivados de ergolina. - Google Patents

Procedimiento para la preparacion de derivados de ergolina.

Info

Publication number
ES2083564T3
ES2083564T3 ES91902706T ES91902706T ES2083564T3 ES 2083564 T3 ES2083564 T3 ES 2083564T3 ES 91902706 T ES91902706 T ES 91902706T ES 91902706 T ES91902706 T ES 91902706T ES 2083564 T3 ES2083564 T3 ES 2083564T3
Authority
ES
Spain
Prior art keywords
pct
represents hydrogen
alkyl
image
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91902706T
Other languages
English (en)
Inventor
Sergio Mantegani
Gabriella Traquandi
Tiziano Bandiera
Enzo Brambilla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909001774A external-priority patent/GB9001774D0/en
Priority claimed from GB909025849A external-priority patent/GB9025849D0/en
Application filed by Pharmacia SpA filed Critical Pharmacia SpA
Application granted granted Critical
Publication of ES2083564T3 publication Critical patent/ES2083564T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVADOS DE ERGOLINA DE FORMULA (I), DONDE R REPRESENTA HIDROGENO O C SUB 1 OGENO, CLORO, BROMINA O METILO; BIEN R SUB 2 O R SUB 3 REPRESENTAN HIDROGENO O CONJUNTAMENTE REPRESENTAN UN ENLACE QUIMICO; R SUB 4 REPRESENTA A GRUPO HIDROCARBURO C SUB 1 DEPENDIENTEMENTE HIDROGENO O ALQUILO C SUB 1 7 REPRESENTA HIDROGENO, C SUB 1 UB 3 POSTERIOR CICLIZACION DE LOS COMPUESTOS RESULTANTES. LOS COMPUESTOS DE FORMULA (I) SE SABE QUE SON AGENTES UTILES ANXIOLITICOS, ANTISICOTICOS Y ANTIPARKINSONIANOS.
ES91902706T 1990-01-25 1991-01-21 Procedimiento para la preparacion de derivados de ergolina. Expired - Lifetime ES2083564T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001774A GB9001774D0 (en) 1990-01-25 1990-01-25 Process for preparing ergoline derivatives
GB909025849A GB9025849D0 (en) 1990-11-28 1990-11-28 Process for preparing ergoline derivatives

Publications (1)

Publication Number Publication Date
ES2083564T3 true ES2083564T3 (es) 1996-04-16

Family

ID=26296553

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91902706T Expired - Lifetime ES2083564T3 (es) 1990-01-25 1991-01-21 Procedimiento para la preparacion de derivados de ergolina.

Country Status (21)

Country Link
US (1) US5210194A (es)
EP (1) EP0464178B1 (es)
JP (1) JPH04504582A (es)
KR (1) KR920701205A (es)
AT (1) ATE131167T1 (es)
AU (1) AU644625B2 (es)
CA (1) CA2049053A1 (es)
DE (1) DE69115138T2 (es)
DK (1) DK0464178T3 (es)
ES (1) ES2083564T3 (es)
FI (1) FI96113C (es)
GR (1) GR3019125T3 (es)
HU (1) HU208971B (es)
IE (1) IE72142B1 (es)
IL (1) IL96996A (es)
MY (1) MY106383A (es)
NO (1) NO178373C (es)
NZ (1) NZ236852A (es)
PT (1) PT96557B (es)
RU (1) RU2074857C1 (es)
WO (1) WO1991011447A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
PL304893A1 (en) * 1992-12-24 1995-01-09 Erba Carlo Spa Serotoninergic derivatives of ergoline
GB9407637D0 (en) 1994-04-18 1994-06-08 Erba Carlo Spa Serotoninergic abeo-ergoline derivatives
GB9603226D0 (en) * 1996-02-15 1996-04-17 Pharmacia Spa Heterocyclyl-ergoline derivatives
US6060483A (en) * 1996-06-27 2000-05-09 Pharmacia & Upjohn S.P.A. Antineurodegenerative ergoline derivatives
KR100620435B1 (ko) 2001-06-08 2006-09-12 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. 소마토스타틴-도파민 키메라 유사체
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
WO2014070965A2 (en) 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763161A (en) * 1970-07-13 1973-10-02 Du Pont Tetrasubstituted dicyanopyrazines and related compounds
JPS58172012A (ja) * 1982-04-01 1983-10-08 Clarion Co Ltd 同一放送識別受信機
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
US4806538A (en) * 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
DE3517247A1 (de) * 1985-05-13 1986-11-13 Gerhard Prof. Dr.-Ing. 8012 Ottobrunn Flachenecker Antennendiversity-empfangsanlage zur elimination von empfangsstoerungen
US4871736A (en) * 1986-11-25 1989-10-03 The Ohio State University Stereoisomeric tricyclic bis(dioxopiperazines) and pharmaceutical compositions
US4733402A (en) * 1987-04-23 1988-03-22 Signatron, Inc. Adaptive filter equalizer systems
DE3814899A1 (de) * 1988-05-03 1989-11-16 Hirschmann Richard Gmbh Co Empfangsverfahren und empfangs-antennensystem fuer mobilen empfang
NO175659C (no) * 1988-07-06 1994-11-09 Sumitomo Electric Industries Kommunikasjonssystem med multippelmottagning og mottagerapparat for diversitetssignaler
DE3926336C2 (de) * 1989-08-09 2001-03-29 Heinz Lindenmeier Antennendiversity-Empfangsanlage zur Elimination von Empfangsstörungen beim mobilen Empfang von Fernsehsignalen

Also Published As

Publication number Publication date
FI96113C (fi) 1996-05-10
IL96996A0 (en) 1992-03-29
KR920701205A (ko) 1992-08-11
RU2074857C1 (ru) 1997-03-10
PT96557A (pt) 1991-10-15
US5210194A (en) 1993-05-11
PT96557B (pt) 1998-07-31
CA2049053A1 (en) 1991-07-26
ATE131167T1 (de) 1995-12-15
NO178373B (no) 1995-12-04
HUT58092A (en) 1992-01-28
NO913647L (no) 1991-09-16
WO1991011447A1 (en) 1991-08-08
JPH04504582A (ja) 1992-08-13
GR3019125T3 (en) 1996-05-31
MY106383A (en) 1995-05-30
DE69115138T2 (de) 1996-05-09
IE910244A1 (en) 1991-07-31
DE69115138D1 (de) 1996-01-18
AU644625B2 (en) 1993-12-16
DK0464178T3 (da) 1996-01-02
IL96996A (en) 1994-11-28
HU208971B (en) 1994-02-28
EP0464178A1 (en) 1992-01-08
NO178373C (no) 1996-03-13
IE72142B1 (en) 1997-03-26
FI96113B (fi) 1996-01-31
EP0464178B1 (en) 1995-12-06
NZ236852A (en) 1992-05-26
FI914458A0 (fi) 1991-09-23
NO913647D0 (no) 1991-09-16
AU7078891A (en) 1991-08-21

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