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KR910015298A - 오메프라졸 직장투여조성물 - Google Patents

오메프라졸 직장투여조성물 Download PDF

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Publication number
KR910015298A
KR910015298A KR1019900002526A KR900002526A KR910015298A KR 910015298 A KR910015298 A KR 910015298A KR 1019900002526 A KR1019900002526 A KR 1019900002526A KR 900002526 A KR900002526 A KR 900002526A KR 910015298 A KR910015298 A KR 910015298A
Authority
KR
South Korea
Prior art keywords
omeprazole
soluble
water
composition according
rectal
Prior art date
Application number
KR1019900002526A
Other languages
English (en)
Other versions
KR930000861B1 (ko
Inventor
김광식
Original Assignee
임성기
한미약품공업 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 임성기, 한미약품공업 주식회사 filed Critical 임성기
Priority to KR1019900002526A priority Critical patent/KR930000861B1/ko
Priority to EP91102856A priority patent/EP0444625B1/en
Priority to DE69102307T priority patent/DE69102307T2/de
Priority to CA002037101A priority patent/CA2037101C/en
Priority to ES91102856T priority patent/ES2057628T3/es
Priority to JP3119605A priority patent/JPH0751503B2/ja
Priority to US07/661,652 priority patent/US5219870A/en
Publication of KR910015298A publication Critical patent/KR910015298A/ko
Application granted granted Critical
Publication of KR930000861B1 publication Critical patent/KR930000861B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

오메프라졸 직장투여조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본발명에 있어서의 조성물에 사용되는 방출화제의 사용량에 따른 시간별 방출률을 나타낸 그래프이다.

Claims (9)

  1. 오메프라졸을 유효성분으로 함유하는 조성물에 있어서, 기제로서 수용성 또는 유용성 기제를 함유하고 있으며, 안정화제로서는 수용성 염기성아미노산을 함유하고 있는 것을 특징으로 하는 오메프라졸 직장투여조성물.
  2. 제1항에 있어서, 상기 수용성기제로서는 폴리에틸렌 글리콜조합이 함유되어 있는 것을 특징으로 하는 오메프라졸 직장투여조성물.
  3. 제1항에 있어서, 상기 유용성개제로서는 아뎁스솔리두스가 함유되어 있는 것을 특징으로 하는 오메프라졸 직장투여조성물.
  4. 제1항에 또는 제3항에 있어서, 상기 유용성 기제가 함유되어 있는 경우에는 방출화제로서 소디움라우릴설페이트를 함유하고 있는 것을 특징으로 하는 오메프라졸 직장투여조성물.
  5. 제4항에 있어서, 상기 방출화제는 조성물의 전체량에 대하여 0.05 내지 1.0중량% 범위로 함유되어 있는 것을 특징으로 하는 오메프라졸 직장투여조성물.
  6. 제1항에 있어서, 상기 수용성 염기성아미노산은 아르기닌, 리진 또는 히스티딘인 것을 특징으로 하는 오메프라졸 직장투여조성물.
  7. 제1항 또는 제6항에 있어서 상기 수용성염기성아미노산은 상기 오메프라졸 1몰에 대해 0.1 내지 20몰로 함유되어 있는 것을 특징으로 하는 오메프라졸 직장투여조성물.
  8. 오메프라졸을 유효성분으로 하는 조성물을 제조함에 있어서, 수용성 또는 유용성 기제를 70∼80℃로 냉각시킨 다음, 여기에다 안정화제로서의 수용성 염기성아미노산과 유효성분인 오메프라졸을 첨가하여 혼합시켜서, 이를 필름에 충진, 냉각시킴을 특징으로 하는 오메프라졸 직장투여조성물.
  9. 제8항에 있어서, 상기 수용성 염기성아미노산은 상기 오메프라졸 1몰에 대해 0.1 내지 20몰의 비율로 첨가하여서 됨을 특징으로 하는 오메프라졸 직장투여조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019900002526A 1990-02-27 1990-02-27 오메프라졸 직장투여 조성물 KR930000861B1 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1019900002526A KR930000861B1 (ko) 1990-02-27 1990-02-27 오메프라졸 직장투여 조성물
EP91102856A EP0444625B1 (en) 1990-02-27 1991-02-26 Omeprazole compositions designed for administration in Rectum
DE69102307T DE69102307T2 (de) 1990-02-27 1991-02-26 Omeprazolezusammensetzung zur rektalen Anwendung.
CA002037101A CA2037101C (en) 1990-02-27 1991-02-26 Omeprazole compositions designed for administration in rectum
ES91102856T ES2057628T3 (es) 1990-02-27 1991-02-26 Composiciones de omeprazol diseñadas para administracion rectal y su proceso de preparacion.
JP3119605A JPH0751503B2 (ja) 1990-02-27 1991-02-27 オメプラゾールの直腸投与組成物
US07/661,652 US5219870A (en) 1990-02-27 1991-02-27 Omeprazole compositions designed for administration in rectum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019900002526A KR930000861B1 (ko) 1990-02-27 1990-02-27 오메프라졸 직장투여 조성물

Publications (2)

Publication Number Publication Date
KR910015298A true KR910015298A (ko) 1991-09-30
KR930000861B1 KR930000861B1 (ko) 1993-02-08

Family

ID=19296479

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900002526A KR930000861B1 (ko) 1990-02-27 1990-02-27 오메프라졸 직장투여 조성물

Country Status (7)

Country Link
US (1) US5219870A (ko)
EP (1) EP0444625B1 (ko)
JP (1) JPH0751503B2 (ko)
KR (1) KR930000861B1 (ko)
CA (1) CA2037101C (ko)
DE (1) DE69102307T2 (ko)
ES (1) ES2057628T3 (ko)

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Also Published As

Publication number Publication date
DE69102307T2 (de) 1995-02-09
JPH0751503B2 (ja) 1995-06-05
US5219870A (en) 1993-06-15
JPH04234817A (ja) 1992-08-24
EP0444625A1 (en) 1991-09-04
KR930000861B1 (ko) 1993-02-08
CA2037101C (en) 1997-03-18
EP0444625B1 (en) 1994-06-08
ES2057628T3 (es) 1994-10-16
CA2037101A1 (en) 1991-08-28
DE69102307D1 (de) 1994-07-14

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