[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

KR850001700A - 단순 헤르페스 바이러스 서브유니트 왁진(Herpes Simplex Virus Subuait Vaccine)의 제조방법 - Google Patents

단순 헤르페스 바이러스 서브유니트 왁진(Herpes Simplex Virus Subuait Vaccine)의 제조방법 Download PDF

Info

Publication number
KR850001700A
KR850001700A KR1019840005156A KR840005156A KR850001700A KR 850001700 A KR850001700 A KR 850001700A KR 1019840005156 A KR1019840005156 A KR 1019840005156A KR 840005156 A KR840005156 A KR 840005156A KR 850001700 A KR850001700 A KR 850001700A
Authority
KR
South Korea
Prior art keywords
virus
glycoprotein
subunit
headfest
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019840005156A
Other languages
English (en)
Other versions
KR910005889B1 (ko
Inventor
요오이찌로오 기노 (외 1)
Original Assignee
노나까 사네오
자이단호오진 가가꾸 오요비겟세이 료오호오 겡뀨우쇼
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노나까 사네오, 자이단호오진 가가꾸 오요비겟세이 료오호오 겡뀨우쇼 filed Critical 노나까 사네오
Publication of KR850001700A publication Critical patent/KR850001700A/ko
Application granted granted Critical
Publication of KR910005889B1 publication Critical patent/KR910005889B1/ko
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

단순 헤르페스 바이러스 서브유니트 왁진(Herpes Simplex Virus Subuait Vaccine)의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명 왁진 접종후 경과일수에 따른 면역군 및 대조군의 생존율을 도시한 그래프이다.

Claims (9)

  1. 단순 헤르페스 바이러스 타입 1 및 타입 2에 공통되는 성분인 글리코프로테인gB를 주요 활성성분으로 하는 단순 헤르페스 바이러스 서브유니트 왁진.
  2. 제1항에 있어서, 글리코프로테인 gB가 단순 헤르페스 바이러스 타입 1 및 타입 2 또는 바이러스로 감염된 세포로 부터 제조되는 단순 헤르페스 바이러스 서브유니트 왁진.
  3. 제1항에 있어서, 글리코프로테인 gB가 리간드로서 글리코프로테인 gB에 대한 단일영양계 항체를 사용하는 친화성 크로마토그래피 분리에 의한 정제 생성물인 단순 헤드페스 바이러스 서브유니트.
  4. 제1항에 있어서, 알미늄겔이 혼합되는 단순 헤드페스 바이러스 서브유니트.
  5. 제1항에 있어서, 왁진이 동결건조 생성물 형태인 단순 헤드페스 바이러스 서브유니트.
  6. 제5항에 있어서, 왁진이 아미노산 또는 그 염 및 사카라이드로 구성되는 군에서 선정된 안정제가 혼합된 단순 헤드페스 바이러스 서브유니트.
  7. 제6항에 있어서, 안정제가 1개 이상의 아미노산 또는 그 염과 1개 이상의 사카라이드의 혼합물인 단순 헤드페스 바이러스 서브유니트.
  8. 단순 헤드페스 바이러스 글리코프로테인 함유용액을 리간드로서 단순 헤드페스 바이러스 글리코프로테인 gB에 대한 단일영양계 항체를 사용하는 친화성 크로마토그래피 분리를 행하며, 또 수득 정제 글리코프로테인 gB를 알미늄겔 상에 흡착시켜 글리코프로테인 gB-흡착 알미늄 겔 분산액을 수득하는 단계로 구성되는 단순 헤드페스 서브유니트 왁진의 제조방법.
  9. 제 8항에 있어서, 단순 헤드페스 바이러스 글리코프로테인 함유용액이 단순 헤드페스 타입 1 또는 타입 2의 입자 또는 바이러스로 감염된 세포의 바이러스 엔베토프 성분을 계면활성제와 함께 용해처리하여 수득되는 용액인 단순 헤르페스 서브유니트 왁진의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840005156A 1983-08-31 1984-08-24 단순 헤르페스 바이러스 서브유니트 왁진(Herpes Simplex Virus Subunit Vaccine)의 제조방법 Expired KR910005889B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP83-159641 1983-08-31
JP58159641A JPS6051120A (ja) 1983-08-31 1983-08-31 単純ヘルペスサブユニットワクチン

Publications (2)

Publication Number Publication Date
KR850001700A true KR850001700A (ko) 1985-04-01
KR910005889B1 KR910005889B1 (ko) 1991-08-06

Family

ID=15698148

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005156A Expired KR910005889B1 (ko) 1983-08-31 1984-08-24 단순 헤르페스 바이러스 서브유니트 왁진(Herpes Simplex Virus Subunit Vaccine)의 제조방법

Country Status (9)

Country Link
US (1) US4661349A (ko)
EP (1) EP0135841B1 (ko)
JP (1) JPS6051120A (ko)
KR (1) KR910005889B1 (ko)
AT (1) ATE79548T1 (ko)
AU (1) AU571569B2 (ko)
CA (1) CA1244766A (ko)
DE (1) DE3485873T2 (ko)
SU (1) SU1554755A3 (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171568A (en) * 1984-04-06 1992-12-15 Chiron Corporation Recombinant herpes simplex gb-gd vaccine
US5244792A (en) * 1984-04-06 1993-09-14 Chiron Corporation Expression of recombinant glyoprotein B from herpes simplex virus
US5612041A (en) * 1984-07-17 1997-03-18 Chiron Corporation Recombinant herpes simplex gD vaccine
US4689225A (en) * 1984-11-02 1987-08-25 Institut Merieux Vaccine for cytomegalovirus
US4790987A (en) * 1985-11-15 1988-12-13 Research Corporation Viral glycoprotein subunit vaccine
ATE136468T1 (de) * 1986-10-20 1996-04-15 Chiron Corp Impfstoff zur behandlung von hsv
US5149529A (en) * 1988-04-08 1992-09-22 Board Of Trustees Of Leland Chiron Corporation Compositions and treatment for herpes simplex
US5151267A (en) * 1988-07-15 1992-09-29 University Of Saskatchewan Bovine herpesvirus type 1 polypeptides and vaccines
US5585264A (en) * 1988-07-15 1996-12-17 University Of Saskatchewan Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides
US5081010A (en) * 1989-02-09 1992-01-14 Eastman Kodak Company Extraction composition, test kit and their use to extract or determine herpes simplex viral antigen
EP0471778A1 (en) * 1989-05-12 1992-02-26 Ciba Corning Diagnostics Corp. Herpes simplex virus type 2-glycoprotein g proteins and polypeptides
US6174916B1 (en) 1990-04-27 2001-01-16 Milkhaus Laboratory, Ltd. Methods for treating herpes virus infections
ATE179614T1 (de) * 1990-08-02 1999-05-15 Chiron Corp Herpes simplex virus vp16 impfstoffe
US5334503A (en) * 1991-10-08 1994-08-02 Eastman Kodak Company Test kit and method for the detection of microorganisms associated with periodontal diseases using surfactant mixture as extraction composition
US5807557A (en) * 1994-07-25 1998-09-15 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex
US6156319A (en) * 1994-07-25 2000-12-05 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex vaccine
US6290967B1 (en) * 1996-12-20 2001-09-18 Merck & Co., Inc. Stabilizers for lyophilized vaccines
US6051385A (en) * 1997-10-22 2000-04-18 The Regents Of The University Of Michigan Compositions and methods for identifying and testing therapeutics against HSV infection
AU2001286407A1 (en) * 2000-08-01 2002-03-04 University Of Pittsburgh Of The Commonwealth System Of Higher Education Antiviral compounds derived from the hsv gd protein and methods
EP1494030B1 (en) * 2003-06-30 2013-11-27 Sysmex Corporation Sample pretreatment solution for influenza virus test by immunochromatography
WO2019086463A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
US20220193222A1 (en) * 2018-11-30 2022-06-23 Vaccine Stabilization Institute Viral formulations containing amino acids

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374127A (en) * 1977-09-19 1983-02-15 Merck & Co., Inc. Herpes sub unit vaccine
FI66020C (fi) * 1977-09-19 1984-08-10 Merck & Co Inc Foerfarande foer framstaellning av antigeniska immunogeniska subunits av hsv-1 och hsv-2
IT1117218B (it) * 1979-05-18 1986-02-17 Depa Sas Procedimento per la produzione di un prodotto per la diagnosi dei tumori delle parti molli o carcinomi e prodotto ottenuto
US4341754A (en) * 1980-01-24 1982-07-27 Vanderbilt University Diagnostic reagent for herpes simplex virus encephalitis
US4337242A (en) * 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4452734A (en) * 1980-02-11 1984-06-05 Merck & Co., Inc. Herpes subunit vaccine
US4430437A (en) * 1980-08-27 1984-02-07 The United States Of America As Represented By The Department Of Health And Human Services Test methods employing monoclonal antibodies against Herpes simplex virus types 1 and 2 nucleocapsids proteins
US4540669A (en) * 1980-09-11 1985-09-10 Merck & Co., Inc. Herpes simplex type I subunit vaccine
US4317811A (en) * 1980-09-11 1982-03-02 Merck & Co., Inc. Herpes simplex type 1 subunit vaccine
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
US4762708A (en) * 1982-02-18 1988-08-09 University Patents, Inc. Materials and methods for herpes simplex virus vaccination
US4535057A (en) * 1982-07-26 1985-08-13 Amf Incorporated Immunoassay employing monoclonal herpes simplex antibody and biotin-avidin detection system
DE3228501A1 (de) * 1982-07-30 1984-02-02 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines herpes-antigens, dazu geeignetes mittel sowie verfahren zu seiner herstellung und die verwendung dieses antigens
EP0133063B1 (en) * 1983-06-23 1987-01-07 Stanley Dr. Person Immunologically reactive non-glycosylated amino acid chains of glycoprotein b of herpes virus types 1 and 2
US4533496A (en) * 1984-05-08 1985-08-06 Monsanto Company Method of isolating monoclonal antibodies from hybridoma cultures

Also Published As

Publication number Publication date
SU1554755A3 (ru) 1990-03-30
DE3485873D1 (en) 1992-09-24
AU571569B2 (en) 1988-04-21
CA1244766A (en) 1988-11-15
KR910005889B1 (ko) 1991-08-06
DE3485873T2 (de) 1993-03-25
EP0135841B1 (en) 1992-08-19
US4661349A (en) 1987-04-28
EP0135841A3 (en) 1986-05-28
JPS6051120A (ja) 1985-03-22
AU3254184A (en) 1985-03-07
ATE79548T1 (de) 1992-09-15
EP0135841A2 (en) 1985-04-03

Similar Documents

Publication Publication Date Title
KR850001700A (ko) 단순 헤르페스 바이러스 서브유니트 왁진(Herpes Simplex Virus Subuait Vaccine)의 제조방법
ATE162402T1 (de) Oraler an der oberfläche von erythrozyten gebundene antigene beinhaltender impfstoff
NO20003716D0 (no) Protein D for anvendelse in vitro, renset antistoff som binder proteinet, samt anvendelser derav
WO2004001007A3 (en) Buffered formulations for concentrating antibodies and methods of use thereof
KR840003420A (ko) 왁진 조성물
DE69233489D1 (de) Verfahren zur Herstellung von Diagnostica
KR900009095A (ko) 합성 항원, 이의 제조방법 및 용도
NO933261D0 (no) Blanding til forsterkning av immunforsvaret
GB1257263A (ko)
GB1282163A (en) Modified allergens and a process for their preparation
DK0413188T3 (da) Fremgangsmåde til fremstilling af umodificerede, intravenøst administrerbare IgM- og/eller IgA-holdige immunglobulinpræparater
NO870560L (no) Nytt farmasoeytisk preparat.
Anacker et al. Details of the ultrastructure of Rickettsia prowazekii grown in the chick yolk sac
DE3866408D1 (de) Selbstklebende vorrichtung zur transdermalen verabreichung eines wirkstoffs.
CA2056437A1 (en) Production of virus and purification of viral envelope proteins for vaccine use
KR870010870A (ko) 약학 조성물의 제조방법
WO2023172741A3 (en) A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine comprising b- and t-cell antigens, immunogenic composition, and uses thereof
KR840006492A (ko) 플라티늄-디아민 착화물의 제조 방법
JPS5299220A (en) Medicines for bulbospinal paralysis
DE3585713D1 (de) Immunoverstaerker und verfahren zu ihrer herstellung.
EP0129173A3 (en) Malaria associated antigen and preparing process thereof
US3144390A (en) Process for the purification of interferon
IE40794L (en) Influenza vaccine.
KR910016347A (ko) C형 간염 바이러스에 대한 초면역 글로블린 및 이의 제조방법
Laver et al. Preparation and immunogenicity of a purified influenza virus haemagglutinin and neuraminidase subunit vaccine

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19840824

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19890302

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19840824

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19910327

Patent event code: PE09021S01D

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19910711

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19911026

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19911101

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19911101

End annual number: 3

Start annual number: 1

PR1001 Payment of annual fee

Payment date: 19940701

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 19950705

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 19960702

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 19970625

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 19980630

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 19990629

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20000624

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20010704

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20020708

Start annual number: 12

End annual number: 12

FPAY Annual fee payment

Payment date: 20030627

Year of fee payment: 13

PR1001 Payment of annual fee

Payment date: 20030627

Start annual number: 13

End annual number: 13

EXPY Expiration of term
PC1801 Expiration of term