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KR850001172A - 이미다졸릴기를 갖는 디페닐 아조메틴의 제조방법 - Google Patents

이미다졸릴기를 갖는 디페닐 아조메틴의 제조방법 Download PDF

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Publication number
KR850001172A
KR850001172A KR1019840003647A KR840003647A KR850001172A KR 850001172 A KR850001172 A KR 850001172A KR 1019840003647 A KR1019840003647 A KR 1019840003647A KR 840003647 A KR840003647 A KR 840003647A KR 850001172 A KR850001172 A KR 850001172A
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KR
South Korea
Prior art keywords
azomethine
diphenyl
group
imidazolyl
methyl
Prior art date
Application number
KR1019840003647A
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English (en)
Inventor
장-피에르 카플랑
Original Assignee
이. 뚜레-라마이뜨르
신떼라보
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이. 뚜레-라마이뜨르, 신떼라보 filed Critical 이. 뚜레-라마이뜨르
Publication of KR850001172A publication Critical patent/KR850001172A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

이미다졸릴기를 갖는 디페닐 아조메틴의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식
    의 벤조페논을 화합물 H2N(CH2)nR(III)의 또는 그의 히드로클로라이드와 반응시키는 단계로 이루어지는 것을 특징으로 하는 다음 일반식,
    의 디페닐 아조메틴을 제조하는 방법.
    상기 (I), (II) 및 (III)식에서 X1,X2,X3및 X4는 같거나 다를수도 있는데 각각 수소 또는 할로겐원자 또는 니트로, 시아노, 히드록시, 메톡시, C1-C3-알킬, 알릴 또는 페닐기를 나타내고, R은 2-(1H-이미다졸릴)기를 나타내고 n=1이거나 또는 R은 4-(1H-이미다졸릴)기를 나타내고, n=1 또는 2이다.
  2. 제1항에 있어서, X1및 X3는 각각 할로겐, 불소, 염소 또는 브롤원자를 나타내고 X2는 수소원자 또는 메틸 또는 알릴기를 나타내는 것을 특징으로 하는 디페닐 아조메틴의 제조방법.
  3. 5-클로로-2-히드록시페닐 2-클로로페닐케톤을 4-이미다졸릴메틸아민과 반응시키는 단계로 이루어지는 것을 특징으로 하는 4-클로로-2-[(2-클로로페닐)-{[4-(1H-이미다졸릴-메틸]이미노}메틸]페놀을 제조하는 방법.
  4. 제1항 또는 제2항 또는 제3항에 있어서, (II)와 (III)사이의 반응은 20 내지 110℃의 온도에 용매내에서, 선택적으로 염기의 존재하에 실행되는 것을 특징으로 하는 디페닐아조메틴의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840003647A 1983-07-01 1984-06-27 이미다졸릴기를 갖는 디페닐 아조메틴의 제조방법 KR850001172A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8310974A FR2548183B1 (fr) 1983-07-01 1983-07-01 Diphenylazomethines portant un radical imidazolyle, leur preparation et leur application en therapeutique
FR10974 1983-07-01

Publications (1)

Publication Number Publication Date
KR850001172A true KR850001172A (ko) 1985-03-16

Family

ID=9290407

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003647A KR850001172A (ko) 1983-07-01 1984-06-27 이미다졸릴기를 갖는 디페닐 아조메틴의 제조방법

Country Status (17)

Country Link
US (1) US4558062A (ko)
EP (1) EP0133061A1 (ko)
JP (1) JPS6036462A (ko)
KR (1) KR850001172A (ko)
AU (1) AU3004384A (ko)
CA (1) CA1220783A (ko)
DK (1) DK320084A (ko)
ES (1) ES8503337A1 (ko)
FI (1) FI842644A (ko)
FR (1) FR2548183B1 (ko)
GR (1) GR79541B (ko)
HU (1) HU192987B (ko)
IL (1) IL72257A0 (ko)
NO (1) NO842636L (ko)
NZ (1) NZ208719A (ko)
PT (1) PT78827B (ko)
ZA (1) ZA844999B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600648B1 (fr) * 1986-06-27 1988-09-09 Synthelabo N-imidazolylmethyl-diphenylazomethines, leur preparation et leur application en therapeutique
FR2661909B1 (fr) * 1990-05-09 1997-08-14 Inst Nat Sante Rech Med Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2110663B (en) * 1981-12-04 1985-08-07 Farmos Group Ltd Imidazole derivatives

Also Published As

Publication number Publication date
FR2548183A1 (fr) 1985-01-04
ZA844999B (en) 1985-02-27
ES533830A0 (es) 1985-02-16
FI842644A0 (fi) 1984-06-29
US4558062A (en) 1985-12-10
PT78827B (fr) 1986-09-10
EP0133061A1 (fr) 1985-02-13
IL72257A0 (en) 1984-12-31
NZ208719A (en) 1986-10-08
AU3004384A (en) 1985-01-03
FR2548183B1 (fr) 1985-10-31
JPS6036462A (ja) 1985-02-25
PT78827A (fr) 1984-07-01
DK320084A (da) 1985-01-02
HUT34958A (en) 1985-05-28
ES8503337A1 (es) 1985-02-16
CA1220783A (en) 1987-04-21
FI842644A (fi) 1985-01-02
DK320084D0 (da) 1984-06-29
HU192987B (en) 1987-08-28
GR79541B (ko) 1984-10-30
NO842636L (no) 1985-01-02

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