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KR840001578A - 9,10-치환된 2-메시틸이미노-3-알킬-3,4,6,7-테트라하이드로-2H-피리미도(6,1-a)이소퀴놀린-4-온의 제조방법 - Google Patents

9,10-치환된 2-메시틸이미노-3-알킬-3,4,6,7-테트라하이드로-2H-피리미도(6,1-a)이소퀴놀린-4-온의 제조방법 Download PDF

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Publication number
KR840001578A
KR840001578A KR1019820004064A KR820004064A KR840001578A KR 840001578 A KR840001578 A KR 840001578A KR 1019820004064 A KR1019820004064 A KR 1019820004064A KR 820004064 A KR820004064 A KR 820004064A KR 840001578 A KR840001578 A KR 840001578A
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KR
South Korea
Prior art keywords
alkyl
formula
carbon atoms
compound
mesitylimino
Prior art date
Application number
KR1019820004064A
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English (en)
Other versions
KR880001281B1 (ko
Inventor
랄 반시 (외 6)
Original Assignee
하인리히 벡커 베른하르트 벡크
훽스트 아크티엔 게젤샤프트
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Publication of KR840001578A publication Critical patent/KR840001578A/ko
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Publication of KR880001281B1 publication Critical patent/KR880001281B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

9, 10-치환된 2-메시틸이미노-3-알킬-3,4,6,7-테트라하이드로-2H-피리미도(6,1-a)이소퀴놀린-4-온의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(Ⅱ)의 화합물을 다음 일반식(Ⅲ)의 에피할로하이드린과 반응시킨 후 수득한 생성물을 다음 일반식(Ⅳ)의 화합물과 반응시켜 다음 일반식(Ⅰ)의 화합물을 제조함을 특징으로 하는, 다음 일반식(Ⅰ)의 화합물 및 이의 약학적으로 내성인 염의 제조방법.
  3. 상기 식에서, R은 탄소수 1 내지 4의 알킬이고, 치환기 X 및 Y중 하나는 탄소수 1 내지 4의 알킬이며, 다른 하나는 식 -CH2CH(OR1) CH2NR2R3의 기이고, R1, R2및 R3는 동일하거나 다르고, 수소 또는 탄소수 1 내지 4의 알킬이거나, 또는 R2및 R3는 결합된 질소원자와 함께, 질소 또는 산소원자를 더 함유하는 임의로 치환된 헤테로사이클기이고, 치환기 x′ 및 y′중 하나는 수소이고, 다른하나는 탄소수 1 내지 4의 알킬이며, Z는 할로겐원자이다.
  4. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8204064A 1981-09-10 1982-09-08 9,10-치환된 2-메시틸이미노-3-알킬-3,4,6,7-테트라하이드로-2H-피리미도(6,1-a)이소퀴놀린-4-온의 제조방법 KR880001281B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19813135831 DE3135831A1 (de) 1981-09-10 1981-09-10 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DEP3135831.4 1981-09-10
DE3135831.4 1981-09-10

Publications (2)

Publication Number Publication Date
KR840001578A true KR840001578A (ko) 1984-05-07
KR880001281B1 KR880001281B1 (ko) 1988-07-18

Family

ID=6141286

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204064A KR880001281B1 (ko) 1981-09-10 1982-09-08 9,10-치환된 2-메시틸이미노-3-알킬-3,4,6,7-테트라하이드로-2H-피리미도(6,1-a)이소퀴놀린-4-온의 제조방법

Country Status (13)

Country Link
US (1) US4590197A (ko)
EP (1) EP0075165B1 (ko)
JP (1) JPS5857380A (ko)
KR (1) KR880001281B1 (ko)
AT (1) ATE23159T1 (ko)
AU (1) AU8815182A (ko)
CA (1) CA1216584A (ko)
DE (2) DE3135831A1 (ko)
DK (1) DK403782A (ko)
ES (1) ES8400747A1 (ko)
FI (1) FI823107L (ko)
IL (1) IL66753A0 (ko)
ZA (1) ZA826620B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS5855362A (ja) * 1981-09-30 1983-04-01 凸版印刷株式会社 転写装飾板の製造方法
JPS58140356A (ja) * 1982-02-09 1983-08-20 電気化学工業株式会社 ライニング材
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011321A (en) * 1973-12-19 1977-03-08 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting β-adrenergic receptors
AR206061A1 (es) * 1974-11-15 1976-06-23 Knoll Ag Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
GB1574665A (en) * 1976-05-08 1980-09-10 Otsuka Pharma Co Ltd 3,4-dihydrocarbostyril derivatives and process for preparing the same
IN147624B (ko) * 1976-12-10 1980-05-03 Hoechst Pharma
NZ185900A (en) * 1976-12-10 1981-04-24 Hoechst Ag Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
IN149457B (ko) * 1978-03-10 1981-12-12 Hoechst Pharma
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
AU8815182A (en) 1983-03-17
KR880001281B1 (ko) 1988-07-18
IL66753A0 (en) 1982-12-31
ES515587A0 (es) 1983-11-01
DE3135831A1 (de) 1983-04-28
FI823107L (fi) 1983-03-11
ZA826620B (en) 1983-07-27
EP0075165B1 (de) 1986-10-29
ES8400747A1 (es) 1983-11-01
EP0075165A1 (de) 1983-03-30
DK403782A (da) 1983-03-11
US4590197A (en) 1986-05-20
FI823107A0 (fi) 1982-09-08
DE3273979D1 (en) 1986-12-04
CA1216584A (en) 1987-01-13
JPS5857380A (ja) 1983-04-05
ATE23159T1 (de) 1986-11-15

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