KR20240110077A - 담즙정체성 질환 치료를 위한 조성물 및 방법 - Google Patents
담즙정체성 질환 치료를 위한 조성물 및 방법 Download PDFInfo
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Abstract
본 발명은 담즙정체성 질환의 치료 및 예방에 사용하기 위한 조성물 및 방법을 제공한다.
Description
본 발명은 담즙정체성 질환의 치료 및 예방에 사용하기 위한 조성물 및 방법에 관한 것이다.
담즙정체성 질환은 간에서 담즙의 독성 축적을 초래하고, 혈청내 간 효소 수치 상승으로 입증되는 바와 같이 간 기능이 손상되는 병태이다. 이는 간외 담관의 직접적인 막힘(예를 들어, 담석, 염증성 협착, 암 또는 췌장염) 또는 원발성 담도 간경변증(PBC), 원발성 경화 간경변(PSC), 진행성 가족성 간내 답증정체증, 임신 답증정체증, 담관염, 간 질환, 예컨대 알코올성 간 질환, 비-알코올성 지방간염(NASH), 및 간세포 암종, 및 간경변의 다른 원인 질환, 예컨대 낭포성 섬유증 및 이식편 대 숙주 질환으로 인해 야기된 간내 담관 손상으로 인해 발생할 수 있다.
우르소데옥시콜산(UDCA)은 PBC 및 PSC와 같은 담즙정체성 간 질환의 치료제로 보고되어 있다. UDCA는 항-담즙정체성, 항-염증성, 항-세포자멸적 및 보호 특성을 통해 질환 진행을 지연시키는 것으로 여겨진다(Paumgartner 등, Hepatology 36:525-531, 2002). 그러나, PBC의 경우, 환자의 약 40%가 UDCA 치료에 반응하지 못한다(Pares 등, Gastroenterology 130: 715-720, 2006). 또한, 치료는 특히 고투약량으로 투여될 때 심한 부작용을 가질 수 있다. PSC에서 고용량은 상당한 유해 사례의 위험과 연관되어 있었다. 비-천연 담즙산 유도체인 오베티콜산은 UDCA에 대한 반응이 부적절한 성인에서는 UDCA와 조합하여, 또는 UDCA를 용인할 수 없는 성인에서는 단일 요법으로 원발성 담도 담관염(PBC)을 치료하는 것으로 승인되었으며, PSC 치료를 위한 임상 시험에서 연구되고 있다. 그러나, 치료는 심각한 소양증을 포함하여 바람직하지 않은 부작용과 연관될 수 있다. 약리적 개입으로 질환이 제어되지 않는 환자는 종종 간 이식이 필요하다.
위장(GI) 미생물군집은 간과 위장(GI) 관에서 대사, 염증, 면역력 및 담즙산 합성에 영향을 미치는 다양한 일차 및 이차 담즙산의 범위로 간 합성된 접합된 일차 담즙산을 변경하여 담즙산 대사에서 역할을 한다. 간 합성된 담즙산염은 양친매성이고 흡수를 위해 지질 및 다른 소수성 분자를 용해시키는 것을 돕는 세제 특성을 갖는 글리신 또는 타우린 접합된 콜산(CA) 및 케노데옥시 콜산(CDCA)을 포함한다(Ridlon 등, J. Lipid Res. 47:247-259, 2006). 접합된 일차 담즙산염(선택적으로 본 명세서에서 "접합된 일차 담즙산"으로 지칭됨)은 산화, 이성질체화 및 7α-디하이드록실화를 포함한 일련의 미생물 촉매 반응을 통해 이차 담즙산으로 추가로 대사작용될 수 있는 탈접합된 일차 담즙산(본 명세서에서 "일차 담즙산"으로 지칭됨)을 형성하기 위해 특정 장 박테리아에 의해 공 액화된다 수행된다(Ridlon 등, J. Lipid Res. 47:247-259, 2006). 또한, 간은 이들 담즙산 대사물의 접합된 형태를 생성한다(본 명세서에서 “접합된 이차 담즙산"으로 지칭됨). 총 45종 이상의 담즙산이 인간에서 발견되는 것으로 보고되어 있다(Bathena 등, J. Chromatography B 942-943:53-62, 2013). 담즙산 함량 및 신호전달의 변화는 담즙정체성 질환, NASH 및 염증성 질환, 예컨대 염증성 장 질환을 비롯한 다수의 질환 결과와 연관되어 있다(Hofmann, Arch Intern Med 159:2647-2658, 1999; Duboc 등, Gut 63:531-539, 2013; Kohli 등, Dig.Dis. 33:440-446, 2015).
접합된 일차 담즙산염은 적절한 영양소 흡수에 중요하지만, 고농도로 존재하거나 교질입자를 형성할 수 없는 경우 간세포 및 담도 상피 세포에 손상을 일으킬 수 있다(Monte 등, World J. Gastroenterol.15(7):804-816, 2009). 담즙산의 상승된 수준은 또한 간에서 산화적 스트레스 및 세포자멸사를 유발하는 것으로 밝혀졌으며(Sokol 등 Hepatology 17: 869-881, 1993; Faubion 등, Fas.J. Clin.Invest. 103: 137-145, 1999) 및 더 소수성 담즙산은 결장에서의 발암과 연관되어 있다(Debruyne 등, Mutat.Res. 480-481:359-369, 2001). 중단된 FXR 신호전달 및 담즙산 함량은 간암과도 연관되어 있다(Kim 등, Carcinogenesis 28:940-946, 2007). 인간에서, MDR3 유전자의 결함은 진행성 가족성 간내 담즙정체증으로 알려진 유형의 담즙정체증을 초래한다(Deleuze 등, Hepatology 23:904-908, 1996).
효과적인 치료 옵션의 이용가능성이 제한되고 질환의 만성 진행이 주어짐에 따라, 담즙정체성 질환 및 그의 징후 및 증상을 개선 또는 예방하기 위한 치료법이 필요하다.
본 발명은 복수의 생존가능한 박테리아를 포함하는 제형을 제공하며, 여기서 제형은 일차 담즙 대사 활성(예를 들어, 담즙산 또는 담즙산염 가수분해효소적 활성; 또한 하기 참조)을 나타낼 수 있는 적어도 하나의 박테리아 OTU 또는 종 및 약제학적으로 허용가능한 부형제를 포함한다.
일부 구현예에서, OTU 또는 종의 16S rDNA 서열 또는 이의 단편은 도 16의 서열 또는 이의 부분과 적어도 95% 또는 적어도 97% 동일하다(예를 들어, 적어도 98%, 적어도 99% 또는 100% 동일하다)(예를 들어, 하기 참조).
일부 구현예에서, 제형은 일차 담즙산 또는 담즙산염 가수분해효소적 활성과 상이한 특이성을 갖는 이차 담즙산 또는 담즙산염 가수분해효소적 활성, 탈접합, 산화 및 디하이드록실화로 구성된 군으로부터 선택된 활성을 나타낼 수 있는 적어도 하나의 생존가능한 박테리아 OTU 또는 종을 추가로 포함한다.
일부 구현예에서, 제형은 적어도 2개의 상이한 박테리아 OTU 또는 종을 포함한다.
일부 구현예에서, 제형은 2개의 상이한 박테리아 OTU 또는 종을 포함하고, 제형은 산화 및 디하이드록실화 활성을 나타낼 수 있다.
일부 구현예에서, 제형은 표 1의 적어도 2개의 분기군으로부터 선택된 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 45 또는 50개의 OTU 또는 박테리아 종을 포함한다. 다양한 예에서, 표 1의 조성물의 각각의 OTU 또는 박테리아 종의 16S rDNA는 도 16의 적어도 하나의 서열, 또는 이의 부분과 적어도 95% 또는 97% 서열 동일성(예를 들어, 적어도 98%, 적어도 99%, 또는 100% 동일성)을 갖는다(예를 들어, 하기 참조).
일부 구현예에서, 제형은 표 2의 적어도 2개의 분기군으로부터 선택된 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 또는 50개의 OTU 또는 박테리아 종을 포함한다.
일부 구현예에서, 제형은 표 1, 표 2 또는 표 3의 B 또는 C 부분의 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 또는 50개의 OTU 또는 박테리아 종을 포함한다.
일부 구현예에서, 제형은 하기로 구성된 군으로부터 선택된 5, 10, 15, 또는 20개의 분기군으로부터의 하나 이상의 OTU 또는 박테리아 종을 포함한다:1, 6, 86, 87, 90, 100, 101, 164, 195, 196, 197, 203, 204, 및 297.
일부 구현예에서, 제형내 상이한 OTU 또는 종의 수는 60, 50, 30, 20 또는 15 미만이다.
일부 구현예에서, 제형의 하나 이상의 박테리아 OTU 또는 종의 담즙산 또는 담즙산염 가수분해효소, 탈접합, 산화 또는 디하이드록실화 활성은 동물-기반 검정, 세포-기반 검정, 시험관내 검정, 서열분석, 또는 이들 유형의 검정의 조합을 사용하여 검출된다.
일부 구현예에서, 제형의 각각의 박테리아 OTU 또는 종은 가수분해, 탈접합, 산화 또는 디하이드록실화로 구성된 군으로부터 선택된 담즙산 또는 담즙산염 대사 활성을 갖는다.
본 발명은 또한 상기 또는 본원의 다른 곳에 기재된 제형을 포함하는 치료적 제형 또는 조성물을 포함한다. 다양한 구현예에서, 치료적 제형의 생존가능한 박테리아는 소장, 결장 또는 둘 모두에 전달된다.
또한, 담즙정체성 질환 또는 병태로 진단되거나 또는 위험에 처한 대상체를 치료하는 방법으로서, 상기 대상체에게 미생물 조성물 또는 제형(예를 들어, 상기 기재된 제형 참고)을 투여하는 단계를 포함하는 방법이 본 발명에 의해 제공되며, 미생물 조성물내의 적어도 하나의 박테리아 OTU 또는 종은 일차 담즙산 또는 담즙산염을 탈접합시킬 수 있다. 다양한 구현예에서, 미생물 조성물내의 적어도 하나의 OTU 또는 박테리아 종은 일차 담즙산 또는 염을 이차 담즙산 또는 염으로 대사작용할 수 있다. 다양한 구현예에서, OTU의 16S rDNA 서열은 도 16의 서열 또는 이의 부분과 적어도 95% 동일하다(예를 들어, 적어도 98%, 적어도 99%, 또는 100% 동일)(예를 들어, 하기 참고).
본 발명은 담즙정체성 질환 또는 병태로 진단되거나 위험에 처한 대상체를 치료하는 방법을 추가로 제공하며, 상기 방법은 상기 또는 본원의 다른 곳에 기재된 제형을 상기 대상체에게 투여하는 단계를 포함한다.
본 명세서에 기재된 방법의 다양한 구현예에서, 상기 대상체는 일반적인 담즙정체증(GC), 일차 경화 간경변(PSC), 원발성 담도 간경변증(PBS), 진행성 가족성 간내 답증정체증(PFIC), 비-알코올성 지방 간 질환(NAFLD), 비-알코올성 지방간염(NASH), 임신 담즙정체증, 담관염, 간염, 알코올성 간 질환, 간세포 암종, 간경변증, 낭포성 섬유증, 이식편 대 숙주 질환(GVHD) 또는 간외 담관 막힘으로 진단되거나 위험에 처해있다. 다양한 구현예에서, 간외 담관의 막힘은 담석, 염증성 협착, 암 또는 췌장염으로 인한 것이다.
본 발명은 또한 담즙정체성 질환 또는 병태(예를 들어, 상기 기재된 목록 참고)로 진단되거나 위험에 처하여, 오베티콜산(OCA), 우르소데옥시콜산(UDCA), 또는 오베티콜산 또는 UDCA의 유도체가 처방된 대상체를 치료하는 방법을 제공하며, 상기 방법은 상기 대상체에게 하기를 투여하는 단계를 포함한다:(i) CDCA, BSH 활성을 갖는 박테리아, 또는 하나의 활성 및/또는 활성의 둘 모두를 억제할 수 있는 화합물 중 하나 이상을 포함하는 조성물; 및 (ii) 약제학적으로 허용가능한 부형제.
본 발명은 히오콜산(hyocholic acid) 또는 히오콜산의 농도를 증가시킬 수 있는 박테리아를 함유하는 조성물을 추가로, 포함한다.
본 발명은 담즙정체성 질환 또는 병태(예를 들어, 상기 기재된 목록 참고)로 진단되거나 위험에 처한 대상체를 치료하는 방법으로서, 상기 대상체에게 UDCA 및, BSH 활성을 갖지만 리토콜린산(LCA) 수준을 증가시키지는 않는 박테리아를 포함하는 조성물을 투여하는 단계를 포함하는 방법을 포함한다. 다양한 구현예에서, 조성물은 일차 담즙산 또는 염을 이차 담즙산 또는 염으로 대사작용할 수 있는 박테리아를 추가로 포함한다.
치료되는 대상체를 UDCA로 치료하는데 사용하기 위한, BSH 활성을 갖는 박테리아를 포함하는 조성물이 또한 본 발명에 제공되며, 여기서 박테리아는 LCA 수준을 증가시키지 않는다. 다양한 구현예에서, 조성물은 일차 담즙산 또는 염을 이차 담즙산 또는 염으로 대사작용할 수 있는 박테리아를 추가로 포함한다.
일부 구현예에서, 방법은 대상체에게 OCA를 투여하는 단계를 추가로 포함한다.
본 명세서에 기재된 임의의 제형 및 방법의 일부 구현예에서, 미생물 조성물은 인간 배설물로부터 직접 유래되거나, 설계된 조성물이거나, 박테리아 포자를 포함하거나, 포자 형성 박테리아를 포함한다.
본 발명은 담즙정체성 질환 또는 병태(예를 들어, 상기 목록 참조)로 진단되거나 위험에 처한 대상체를 치료하는데 사용하기 위한 상기 및 본원의 다른 곳에서 기재된 바와 같은 제형을 포함하는 조성물을 추가로 제공한다.
또한, 본 발명은 대상체에서 담즙산 대사를 변경시키기 위한 조성물에 사용하기 위한 박테리아 종을 확인하는 방법을 제공한다. 이들 방법은 원하는 담즙산 활성을 촉매하는 단백질의 데이터베이스에서 박테리아 균주의 단백질 코딩 서열을 참조 서열과 비교하는 단계를 포함하며, 여기서 참조 서열과 상동성을 갖는 서열을 포함하는 박테리아 균주의 확인은 조성물에 사용하기 위한 박테리아 균주의 확인을 나타낸다.
다양한 구현예에서, 방법은 시험관내 검정 또는 동물 모델-기반 검정을 사용하여 박테리아 종의 담즙산 대사 활성을 시험하는 단계를 추가로 포함한다.
추가의 구현예에서, 서열 상동성 수준은 적어도 75%, 80%, 85%, 90%, 93%, 95%, 97%, 98%, 99%, 또는 100% 동일성이다.
본 명세서에서 사용된 바와 같이, "증강"은 (i) 치료적 미생물 조성물로부터 (게놈 서열분석 또는 미생물학적 기술과 같은 방법에 의해 결정된 바와 같이) 부재이거나 검출불가능한, (ii) 미생물 조성물의 투여 전 숙주 틈새(예를 들어, 위장관(GI) 관, 예를 들어, 위장관의 내강, 위장관의 점막, 결장, 소장)에 부재이거나, 검출불가능하거나, 낮은 빈도로 존재하거고, 및 (iii) 미생물 조성물의 투여 후에, 또는 미생물이 투여 전에 낮은 빈도로 존재하고, 미생물 조성물의 투여 후; 실시예 2-배, 5-배, 1x102-배, 1x103-배, 1x104-배, 1x105-배, 1x106-배, 1x107-배, 또는 그 초과 1x108-배 상당히 증가하는 경우, 검출가능한 하나 이상의 유형의 미생물(예를 들어, 박테리아)의 확립 또는 유의미한 증가를 지칭한다. 증강된 생태를 포함하는 미생물은 음식 또는 다른 환경 공급원과 같은 외인성 공급원으로부터 유래될 수 있거나, 또는 이들이 낮은 빈도로 거주하는 숙주 내의 틈새로부터 유래될 수 있다. 증가는 특정 유형의 박테리아의 수, 유형의 다양성(예를 들어, 분기군, OTU 또는 박테리아 종)의 증가, 또는 둘 모두일 수 있다. 일부 구현예에서, "검출불가능한” 또는 "낮은" 빈도를 결정하기 위한 비교를 위해 참조 수준이 확립된다.
"분기군"은 계통발생수에서 통계적으로 유효한 노드의 다운스트림에 있는 조작상 분류 단위(OTU 또는 계통발생수의 구성원)를 지칭한다. 분기군은 최대 가능성 방법을 사용하여 전장 16S rDNA 서열로 구성된 계통발생수의 위상기하학을 기반으로 정의된다. 분기군은 주어진 분기군의 모든 OTU가 서로 지정된 수의 부트스트랩 지원 노드 내에 있고 전장 16S rDNA 서열을 기반으로 한 유전적 유사성을 갖도록 구성된다. 동일한 분기군 내에 있는 OTU는 예를 들어 16S rDNA 서열에 기초하여 상이한 분기군에서 OTU와 유전자적으로 및 계통발생적으로 구별되는 것으로 구별될 수 있다. 따라서, 단일 분기군 내의 종은 생태학적 기능을 보존할 가능성이 있고, 조성물에서 상호교환될 수 있다.
"장내세균총불균형"은 점막 또는 피부 표면을 포함하여 대상체내 위장관 또는 다른 신체 영역의 미생물총의 상태를 지칭하며, 여기서 미생물 생태학적 네트워크의 정상 또는 건강한 다양성 및/또는 기능이 파괴된다. 상기 파괴는 예를 들어, 미생물군집의 다양성 감소, 하나 이상의 병원체 또는 공생균의 과성장, 특정 경우에만 질환을 유발할 수 있는 공생 유기체의 존재, 대상체내에 특정 유전적 및/또는 환경 조건이 대상체에게 존재하는 경우에만 질환을 야기할 수 있는 공생 유기체의 존재, 또는 더 이상 숙주 대상체에게 하나 이상의 필수 기능을 제공하지 않으므로 건강을 증진시키거나, 또는 하나 이상의 대사 기능의 균형의 변화를 유발하지 않는 미생물군집으로의 이행으로 인해 발생할 수 있는 건강하지 않은 상태의 미생물군집을 초래한다. 장내세균총불균형은 예를 들어 감염을 치료 또는 예방하기 위해 항생제를 사용함으로써 야기될 수 있다. 일부 경우에, 장내세균총불균형은 예를 들어, 간담도계의 기능 이상으로 인한 장간 담즙 순환의 감소와 같은 숙주 생리학의 변경과 연관되어 있다. 일부 경우에, 장내세균총불균형은 염증 상태, 예를 들어 PSC 또는 궤양성 대장염과 연관되어 있다.
"생착"은 조성물로 처리된 숙주의 GI관 (예를 들어, 소장 또는 대장)과 같은 표적 틈새의 치료적 조성물에 존재하는 박테리아 유형 (예를 들어, 박테리아 분기군, OTU 또는 종)의 확립을 지칭하며, 박테리아 유형은 처리 전에 처리된 숙주에서 부재이거나 검출되지 않았다. 접목된 종 또는 OTU는 최종 투여량 또는 치료의 투여로부터 측정된 바와 같이 확립될 수 있다(예를 들어, 1일, 2일, 3일, 4일, 5일, 6일, 1주, 2주, 3주, 4주, 8주, 12주, 3개월 또는 6개월). 검출 방법은 당 업계에 공지되어 있고, qPCR, 16S v4 차세대 서열분석(NGS) 및 전체 메타게놈(Metagenomic) 서열분석(WMS) 및 다른 고처리량 서열분석 방법을 포함한다. 검출 한계는 예를 들어 10e6에서 하나의 박테리아, 10e7에서 하나 또는 10e8에서 하나의 박테리아의 검출일 수 있다. 일부 구현예에서, 검출 방법은 조성물에 제공된 박테리아 균주를 선택적으로 검출할 수 있다. 일부 구현예에서, 검출 방법은 조성물에 제공된 박테리아의 종 또는 OTU를 선택적으로 검출할 수 있다. 임의의 특정 이론에 의지하지 않으면서, 생착된 미생물 모집단은 상기 표적 틈새에서 환경적 이동을 유도할 수 있고, 이에 의해 불균형적(dysbiotic) 생태로부터 건강한 상태를 나타내는 다른 생태로의 이동을 촉진할 수 있는 공생 미생물의 성장에 유리한 조건을 촉진할 수 있다.
본 명세서에서 사용된 바와 같이 "치료하는" 및 "치료하는"은 질환의 적어도 하나의 징후 증상을 예방 또는 개선하기 위해 질환에 대해 진단되거나 위험에 처한 것으로 예상되는 개체에 제제, 조성물 또는 제형의 투여를 지칭한다. 용어들 "장애" 및 "질환"은 본원에서 상호교환적으로 사용된다. 용어 "예방하는" 및 "예방"은 특정 부정적인 병태, 장애 또는 질환에 걸리기 쉬운 임상적으로 무증상 개체에 제제 또는 조성물을 투여하는 단계를 지칭하며, 따라서 질환의 적어도 하나의 징후 증상의 발생 예방에 관한 것이다. 본 명세서에 사용된 바와 같이, 달리 지시되지 않는 한, 용어 "증상"은 징후 및 증상을 포함한다.
"치료 유효량" 또는 "유효량"의 제제, 조성물, 제형 또는 이들의 조합은 장애의 적어도 하나의 증상을 예방 또는 개선하기에 충분한 양의 제제, 조성물, 제형 또는 이들의 조합이다. 본 명세서에 기재된 치료 유효량의 치료적 조성물은 개체의 질환 상태, 연령, 성별 및 체중, 및 치료적 조성물이 개체에서 원하는 반응을 유도하는 능력, 예를 들어 적어도 하나의 장애 파라미터의 개선, 또는 장애의 적어도 하나의 징후 증상의 개선(및 선택적으로, 투여되는 임의의 추가 효능제의 효과)에 따라 달라질 수 있다. 치료 유효량은 또한 조성물의 임의의 독성 또는 유해 효과가 치료적으로 유익한 효과보다 더 큰 양이다. 본 명세서에 기재된 바와 같은 조성물은 일반적으로 치료 유효량으로 투여된다. 담즙정체성 질환의 증상 또는 관련이 당 업계에 공지되어 있다. 예를 들어, 일반적인 담즙정체증의 증상은 당 업계에 공지되어 있으며, 예를 들어 가려움증, 황달, 간 및 비장 확대, 피로, 메스꺼움 및 구토, 간경변, 간부전, 간암, 담석 및 이러한 증상의 생화학적 마커를 포함할 수 있다.
박테리아의 "유형"은 균주, 종, 분기군, 계열 또는 다른 조직상의 카테고리로 그룹화된 박테리아를 지칭한다. 일부 구현예에서, 박테리아 종은 참조 박테리아의 16S rDNA 서열과 적어도 95%, 적어도 97%, 적어도 98%, 적어도 99%, 또는 적어도 100% 동일한 적어도 하나의 16S rDNA 서열을 갖는 박테리아로 정의된다. 일부 경우에, 박테리아 종은 16S rDNA 서열의 적어도 하나의 가변 영역(V1-V8), 예를 들어, 참조 박테리아의 16S rDNA 가변 영역과 적어도 95%, 적어도 97%, 적어도 98%, 적어도 99%, 또는 적어도 100% 동일한 V4 또는 V6 영역을 갖는 박테리아로 정의된다.
본원에 언급된 각각의 특허 문헌 및 과학 논문 및 그에 인용된 특허 문헌 및 과학 논문의 전체 개시내용은 모든 목적을 위해 본원에 참고로 명시적으로 포함된다.
본 발명의 추가의 특징 및 이점은 이하에 보다 상세하게 기재된다.
도 1a 및 1b는 인간 박테리아 단리물 및 담즙산 대사를 위해 설계된 조성물의 시험관내 스크리닝 결과를 도시한다. 도 1a는 박테리아 종 및 개별 균주에서 다양한 효소적 활성 및 기질 특이성을 나타내는 데이터를 도시한다. 각각의 행은 시험된 개별 균주에 해당한다. 칼럼은 스크리닝 접근법, 및 스크리닝에 사용되는 담즙산 기질에 의해 포괄되는 5가지 카테고리의 효소적 활성을 도시한다. 진한 정사각형은 표시된 기질에 효소적 활성이 있음을 나타내며, 반면 공백은 활성이 없음을 나타낸다. 도 1b는 설계된 조성물 및 이들의 구성성분 균주 및 담즙산 활성을 도시한다. 행은 지시된 조성물 내의 개별 균주를 나타낸다. 컬럼은 각각의 균주에 대한 효소적 활성 및 기질 특이성을 나타낸다. 균주는 또한 활성을 확인하기 위해 완전한 조성물의 혼합물로서 시험되었다. 종 확인에 유용한 적어도 하나의 16S rDNA 서열이 도 16에 제공되어 있다.
도 2는 무균 마우스를 No BA 조성물로 군집화한 실험으로부터의 NGS 데이터를 도시한다. "담즙산 활성이 없는" 조성물을 투약하기 전 및 투약 후 1일, 3일 및 7일후에 수집된 5마리 마우스로부터의 배설물 샘플을 차세대 서열분석(NGS)에 의해 분석하였다. y-축은 각각의 샘플에 대해 최대 20,000회의 판독이 관측된 판독 수를 나타낸다. 개별 분기군은 막대 그래프에서 상이한 음영으로 표시된다. "담즙산 없는" 조성물에서 박테리아에 속하는 3개의 분기군은 진회색, 백색 및 담회색으로 도시되어 있다.
도 3은 설계된 조성물을 이용한 군집화가 무균 마우스에서 배설물 담즙산 함량을 변경할 수 있는지 여부를 시험하는 실험으로부터의 데이터를 도시한다. 데이터는 '무 담즙산(BA 없음) 활성' 조성물, 'BSH 단독 활성' 조성물, 'Max BA 활성' 조성물 또는 '전형화'(마우스-유래된 FMT)로 군집화된 무균 마우스의 배설물 담즙산 프로파일을 설명한다. 처리 당 5마리 마우스를 시험하였고, 담즙산 프로파일은 총 분석된 담즙산 풀의 백분율로서 묘사된다(분석된 담즙산 풀은 샘플에서 검출된 모든 담즙산의 합을 의미함). * Tukey의 다중 비교 테스트를 통해 양방향(2-way) Anova를 기반으로 한 기존의 마우스와 비교했을 때 유의미한 차이를 나타낸다. P-값은 하기와 같다:** p ≤ 0.01, **** p ≤ 0.001.
도 4는 박테리아에 의한 접합된 일차 담즙산염의 이화작용이 간 담즙산 풀을 감소시킬 수 있는지를 조사한 실험 결과를 도시한다. 총 간 담즙산 풀은 야생형, 전형화 및 무균 마우스, 뿐만 아니라 ‘BA 활성 없음’, ‘BSH 단독 활성’ 또는 ‘Max BA 활성’ 조성물로 군집화된 마우스에서 측정되었다. 5마리의 마우스를 각각의 아암(arm)에서 시험하고, 총 간 담즙산을 LC-MS를 사용하여 분석하였고, 결과를 샘플 조직 중량(nM/mg)으로 정규화하였다. 총 담즙산 풀을 간 조직에서 검출된 모든 담즙산의 합으로 결정하고, 순수한 표준으로 보정 곡선을 사용하여 정량화하였다. * 한 쌍의 t-시험에 기초한 무균 마우스와 비교하여 총 담즙산 수준의 유의미한 차이를 나타낸다. P-값은 하기와 같다:*** p ≤ 0.001, **** p ≤ 0.001.
도 5a는 상이한 담즙산 이화작용 활성을 갖는 박테리아 조성물에 의한 무균 마우스의 군집화가 회장 FXR 유전자 발현을 상당히 변화시킬 수 있는지를 조사하는 실험 결과를 도시한다. 담즙산 활성 없음(BA 활성 없음), BSH 단독 활성, 또는 Max BA 활성 조성물로 군집화된 전-생균이 없는 마우스에서 Taqman qPCR에 의해 유전자 발현을 평가하였다. 대조군은 경구 위관영양법("FMT)을 통해 쥣과 배설물로 군집화된 전-생균이 없는 마우스 및 쥣과 미생물총이 있는 종래의 마우스를 포함한다. 발현은 하우스키핑 유전자인 베타-액틴과 관련하여 나타난다. **** Tukey의 다중 비교에 의하면, p ≤ 0.0001 (n=4~8).
도 5b는 뚜렷한 담즙산 활성을 갖는 박테리아 조성물에 의한 무균 마우스의 군집화가 회장 FGF15 유전자 발현에 차등적으로 영향을 미침을 나타내는 실험 결과를 도시한다. 회장 FGF15 발현은 무균 마우스, 통상적으로 하우징된 마우스, 쥣과-유래된 FMT로 군집화된 무균 마우스뿐만 아니라 'BA 활성이 없는 조성물', 'BSH 단독 활성'조성물 또는 'Max BA 활성’ 조성물로 군집화된 마우스에서 평가하였다. 발현은 하우스키핑 유전자인 베타 액틴과 관련하여 나타난다. **** Tukey의 다중 비교에 의하면, P < 0.0001 (n=4~8).
도 6a~6d는 CDCA의 존재 하에서 FXR-활성화된 유전자 발현을 매개하는 오베티콜산(OCA)의 능력을 시험한 실험 결과를 도시한다. 다운스트림 표적 유전자의 발현을 자극하는 오베티콜산(OCA)의 능력은 CDCA의 존재하에 20-배 향상되었다. 도 6a: hFXR 리포터 세포를 일정한 농도의 50 μM CDCA로 CDCA(0~100 μM), OCA(0~10 μM) 또는 OCA(0~10 μM)의 연속 희석으로 24시간 동안 인큐베이션하였다. FXR 활성화는 루시퍼라제 활성의 측정에 의해 평가되었고, 비히클 대조군(0.2% DMSO)에 대한 배수 변화로 표시된다. 각각의 용량을 3회 수행하였다. 도 7b:콜산 식이에 의한 식이 보충은 생체 내에서 FXR 신호전달을 증가시켰다. 도 7c 및 7d.OCA는 FXR 신호전달을 활성화시키고 용량 의존적 방식으로 FXR-의존성 유전자의 발현을 조절하였다. FXR 신호전달은 간에서의 Cyp7A1 및 회장에서의 FGF15를 포함하는 다운-스트림 유전자의 발현 측정에 의해 평가되었다.
도 7a는 HCA가 아닌 CDCA가 시험관내에서 FXR 신호전달을 활성화시킨다는 것을 입증하는 실험 결과를 도시한다. hFXR 루시퍼라제 세포 리포터 분석에서, 선택된 담즙산 단독의 용량 반응 곡선은 FXR 신호전달에 대한, CDCA의 전체 효능제 활성, LCA 및 DCA의 낮은 효능제 활성(시험된 최대 농도는 100 μM) 및 히포콜산의 효능제 활성 없음(HCA; 최대 200 μM)을 나타낸다.
도 7b는 시험관내 FXR 활성화 검정에 기초하여 루시퍼라제에서 50 μM CDCA(도 7a에 도시된 바와 같이 CDCA = 50 μM의 EC50)의 존재하에 히오콜산(HCA)에 의한 FXR의 상승작용 활성화를 입증하는 실험 결과를 도시한다. DCA 및 LCA는 HCA와 상당한 상승 효과를 나타내지 않았다. 100 μM에서의 LCA와 50 μM에서의 CDCA는 세포에 대한 독성 증가로 인해 활성화 배수에 차이가 없음을 보여주었다. 데이터는 50 μM CDCA 단독에 대한 배수 변화로 표현된다.
도 8a 및 8b는 원발성 경화성 담관염(PSC) 환자에서 총 담즙산 수준 및 담즙산 조성물의 변화를 보여주는 실험 결과를 도시한다. 도 8a:환자는 총 관문 혈액 및 말초 혈액 담즙 수준의 상응하는 증가와 함께 담즙의 총 담즙산 수준이 감소된 것으로 나타났다. 도 8b:PSC 환자는 소화관 미생물군집에 의해 전형적으로 생성된 이차 및 접합된 이차 담즙산의 비율이 감소하고, 상응하는 업스트림 접합된 일차 담즙산이 유의미하게 증가함을 보여준다. 담즙산 농도는 정량화를 위한 적절한 참조 표준으로 LC-MS를 사용하여 측정하였다. 데이터는 평균 ± 표준 편차로 표시된다. * Tukey의 다중 비교 테스트를 통한 양방향 Anova를 기반으로 한, PSC와 건강한 환자의 유의미한 차이를 나타낸다. P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001.
도 9a~9g는 DDC-식이 유도 담즙정체성 질환으로 치료된 종래에 하우징된 마우스가 건강한 대조군과 비교하여 변경된 담즙산 함량 및 소화관 미생물 프로파일을 나타내는 실험 결과를 보여준다. 도 9a:알칼리성 포스파타제(ALP), 알라닌 아미노기전달효소(ALT), 총 빌리루빈(TBIL) 및 콜레스테롤(CHOL)을 포함하여 DDC 처리된 종래에 하우징된 스위스 알비노 마우스에서 혈청 바이오마커의 수준이 상당히 증가하여 담즙정체성 간 질환의 존재를 확인했다. 도 9b-9d:DDC-다이어트 유도된 담즙정체성 질환이 있는 마우스는 처리되지 않은 대조군과 비교하여 업스트림 접합된 1º 담즙산의 상응하는 증가와 함께 2º 및 접합된 2º 담즙산의 수준이 감소된 것으로 나타났다. 도 9e:알파 다양성 및 베타 다양성 지수는 담즙정체성 질환을 유도하기 위해 마우스 DDC 처리전(d0) 및 처리후(d21) 마우스에서 뚜렷한 미생물 모집단을 보여준다. 알파 다양성(좌측 그래프)은 Shannon 다양성 지수에 기초한 종 풍부도의 측정치이며, 베타-다양성(우측 그래프)은 원리 좌표 분석(PCoA)을 기반으로 2개의 가중 축에서 분리 거리로 표시된다. 도 9f:담즙정체성 질환을 유발하기 위해 DDC로 처리전(d0) 및 처리후(d21) 마우스간에 유병률(p ≤ 0.2)이 상당히 상이한 종의 목록.도 9g:기존의 스위스 알비노 마우스에서 담즙정체성 질환 진전과 함께 알려진 7α-디하이드록실화 활성으로 균주의 상당한 손실.*는 DDC 처리된 및 대조군 마우스(A~D) 사이 또는 마우스 DDC 처리전(d0) 및 처리후(d21) 마우스간에 유의한 차이를 나타낸다. Tukey의 다중 비교 테스트를 통해 양방향 Anova를 기반으로 하는 유의성 분석.P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001
도 10a~10e는 소화관 미생물군집의 부재가 스위스 알비노 마우스에서, 마우스-유래 FMT에 의한 군집화에 의해 역전될 수 있는 병태인 DDC-식이 유도 담즙정체성 질환에 대한 감수성을 증가시킨다. 무균(GF) 마우스는 보다 빠른 체중 감소(도 10a) 및 DDC 식이로 처리할 때 종래에-하우징된(CH) 마우스와 비교된, 알칼리성 포스파타제(도 10b), 알라닌 아미노기 전달효소(도 10c) 및 총 빌리루빈(도 10d)과 같은 혈청 바이오마커의 수준이 훨씬 더 높음을 나타낸다. GF 마우스에서 스위스 알비노 마우스-유래된 자가-FMT로 4주 동안의 군집화는 체중 감소 및 ALP, ALT 및 TBIL의 수준이 DDC-식이가 주어진 CH 마우스에 비교할만한 수준으로 감소된, DDC-유도된 질환에 대한 이러한 감수성을 역전시킨다. 도 10e는 담즙산 프로파일링의 결과를 보여주며, 이는 FMT 처리가 무균 마우스와 비교하여 소화관에서 담즙산 조성물을 회복시키기에 충분하다는 것을 결정하였다. *는 DDC 처리에서 GF 마우스에 비해 유의한 차이를 나타낸다. Tukey의 다중 비교 테스트를 통해 양방향 Anova를 기반으로 하는 유의성 분석.P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001
도 11a~11e는 미생물 조성물이 DDC-식이 유도된 담즙정체성 간 질환에 대한 감수성에 영향을 준다는 것을 보여준다. 도 11a~11b:무균 C57Bl/6 및 스위스 알비노 마우스는 질환에 대한 종래의 스위스 알비노 마우스의 상당한 저항에도 불구하고 간 질환으로 인한 체중 감소에 비교할만한 감수성을 나타낸다. 도 11c:DDC 식이에서, 종래의 C57Bl/6 공여체 마우스 FMT를 갖는 무균 스위스 알비노 마우스의 군집화는 종래의 스위스 알비노 공여체 마우스로부터 FMT를 받는 스위스 알비노 마우스보다 더 신속한 체중 감소를 초래한다. 도 11d:혈청 ALP 수준은 말단 수집 전 체중 감소의 차이에도 불구하고, 상이한 공여체로부터 FMT로 군집화된 마우스 사이에서 비교할만하게 유지된다. 도 11e:C57Bl/6 공여체 FMT 군집화된 마우스는 스위스 알비노 공여체 FMT 군집화된 마우스와 비교하여 상당히 더 높은 수준의 1º 담즙산 및 더 낮은 수준의 2º 담즙산을 갖는다. (*참고로, 도 11a의 경우, GF-C57 마우스는 다른 3개의 아암과는 별도의 실험의 일부였다. )
도 12a~12c는 미생물군집의 복원이 무균 마우스의 DDC 식이 유도 간 질환에 대한 감수성을 구제한다는 것을 보여준다. 복잡한 종래의 스위스 알비노 마우스 유래 FMT, 또는 담즙산 대사(Max BA)를 회복시키는 덜 복잡한 설계된 조성물에 의한 처리가 무세균 스위스 알비노 마우스에서 DDC 식이에 대한 반응으로 체중 감소(도 12a) 및 ALP 수준(도 12b)을 감소시켰다. 도 12c:종래의 마우스 유래된 FMT 또는 설계된 조성물(Max BA)에 의한 군집화는 무균 마우스에서 배설물 담즙산 서브셋의 대부분을 회복시켰다. *는 DDC 처리에서 GF 마우스에 비해 유의한 차이를 나타낸다. Tukey의 다중 비교 테스트를 통해 양방향 Anova를 기반으로 하는 유의성 분석.P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001
도 13은 이차 담즙산(데옥시콜산 + 리토콜린산)에 의한 식이 보충의, DDC-식이 유도 담즙정체성 질환에 대한 감수성에 대한 유익한 효과를 입증한다. DCA + LCA 보충된 식이의 무균 스위스 알비노 마우스는 DDC 식이에 노출되었을 때 미처리 무균 마우스에 비해 체중 감소율이 감소된 것으로 나타났다.
도 14는 BSH 활성의 생체 정보 예측을 시험관내 분석된 활성과 비교한 결과를 보여주는 그래프 및 표의 세트이다.
도 15는 7α-디하이드록실화 활성의 생체 정보 예측을 시험관내 분석된 활성과 비교한 결과를 나타내는 그래프 및 표이다.
도 16은 본 발명의 다양한 조성물 및 방법에 유용한 예시적인 박테리아로부터의 전장 16S rDNA 서열의 목록이다.
도 2는 무균 마우스를 No BA 조성물로 군집화한 실험으로부터의 NGS 데이터를 도시한다. "담즙산 활성이 없는" 조성물을 투약하기 전 및 투약 후 1일, 3일 및 7일후에 수집된 5마리 마우스로부터의 배설물 샘플을 차세대 서열분석(NGS)에 의해 분석하였다. y-축은 각각의 샘플에 대해 최대 20,000회의 판독이 관측된 판독 수를 나타낸다. 개별 분기군은 막대 그래프에서 상이한 음영으로 표시된다. "담즙산 없는" 조성물에서 박테리아에 속하는 3개의 분기군은 진회색, 백색 및 담회색으로 도시되어 있다.
도 3은 설계된 조성물을 이용한 군집화가 무균 마우스에서 배설물 담즙산 함량을 변경할 수 있는지 여부를 시험하는 실험으로부터의 데이터를 도시한다. 데이터는 '무 담즙산(BA 없음) 활성' 조성물, 'BSH 단독 활성' 조성물, 'Max BA 활성' 조성물 또는 '전형화'(마우스-유래된 FMT)로 군집화된 무균 마우스의 배설물 담즙산 프로파일을 설명한다. 처리 당 5마리 마우스를 시험하였고, 담즙산 프로파일은 총 분석된 담즙산 풀의 백분율로서 묘사된다(분석된 담즙산 풀은 샘플에서 검출된 모든 담즙산의 합을 의미함). * Tukey의 다중 비교 테스트를 통해 양방향(2-way) Anova를 기반으로 한 기존의 마우스와 비교했을 때 유의미한 차이를 나타낸다. P-값은 하기와 같다:** p ≤ 0.01, **** p ≤ 0.001.
도 4는 박테리아에 의한 접합된 일차 담즙산염의 이화작용이 간 담즙산 풀을 감소시킬 수 있는지를 조사한 실험 결과를 도시한다. 총 간 담즙산 풀은 야생형, 전형화 및 무균 마우스, 뿐만 아니라 ‘BA 활성 없음’, ‘BSH 단독 활성’ 또는 ‘Max BA 활성’ 조성물로 군집화된 마우스에서 측정되었다. 5마리의 마우스를 각각의 아암(arm)에서 시험하고, 총 간 담즙산을 LC-MS를 사용하여 분석하였고, 결과를 샘플 조직 중량(nM/mg)으로 정규화하였다. 총 담즙산 풀을 간 조직에서 검출된 모든 담즙산의 합으로 결정하고, 순수한 표준으로 보정 곡선을 사용하여 정량화하였다. * 한 쌍의 t-시험에 기초한 무균 마우스와 비교하여 총 담즙산 수준의 유의미한 차이를 나타낸다. P-값은 하기와 같다:*** p ≤ 0.001, **** p ≤ 0.001.
도 5a는 상이한 담즙산 이화작용 활성을 갖는 박테리아 조성물에 의한 무균 마우스의 군집화가 회장 FXR 유전자 발현을 상당히 변화시킬 수 있는지를 조사하는 실험 결과를 도시한다. 담즙산 활성 없음(BA 활성 없음), BSH 단독 활성, 또는 Max BA 활성 조성물로 군집화된 전-생균이 없는 마우스에서 Taqman qPCR에 의해 유전자 발현을 평가하였다. 대조군은 경구 위관영양법("FMT)을 통해 쥣과 배설물로 군집화된 전-생균이 없는 마우스 및 쥣과 미생물총이 있는 종래의 마우스를 포함한다. 발현은 하우스키핑 유전자인 베타-액틴과 관련하여 나타난다. **** Tukey의 다중 비교에 의하면, p ≤ 0.0001 (n=4~8).
도 5b는 뚜렷한 담즙산 활성을 갖는 박테리아 조성물에 의한 무균 마우스의 군집화가 회장 FGF15 유전자 발현에 차등적으로 영향을 미침을 나타내는 실험 결과를 도시한다. 회장 FGF15 발현은 무균 마우스, 통상적으로 하우징된 마우스, 쥣과-유래된 FMT로 군집화된 무균 마우스뿐만 아니라 'BA 활성이 없는 조성물', 'BSH 단독 활성'조성물 또는 'Max BA 활성’ 조성물로 군집화된 마우스에서 평가하였다. 발현은 하우스키핑 유전자인 베타 액틴과 관련하여 나타난다. **** Tukey의 다중 비교에 의하면, P < 0.0001 (n=4~8).
도 6a~6d는 CDCA의 존재 하에서 FXR-활성화된 유전자 발현을 매개하는 오베티콜산(OCA)의 능력을 시험한 실험 결과를 도시한다. 다운스트림 표적 유전자의 발현을 자극하는 오베티콜산(OCA)의 능력은 CDCA의 존재하에 20-배 향상되었다. 도 6a: hFXR 리포터 세포를 일정한 농도의 50 μM CDCA로 CDCA(0~100 μM), OCA(0~10 μM) 또는 OCA(0~10 μM)의 연속 희석으로 24시간 동안 인큐베이션하였다. FXR 활성화는 루시퍼라제 활성의 측정에 의해 평가되었고, 비히클 대조군(0.2% DMSO)에 대한 배수 변화로 표시된다. 각각의 용량을 3회 수행하였다. 도 7b:콜산 식이에 의한 식이 보충은 생체 내에서 FXR 신호전달을 증가시켰다. 도 7c 및 7d.OCA는 FXR 신호전달을 활성화시키고 용량 의존적 방식으로 FXR-의존성 유전자의 발현을 조절하였다. FXR 신호전달은 간에서의 Cyp7A1 및 회장에서의 FGF15를 포함하는 다운-스트림 유전자의 발현 측정에 의해 평가되었다.
도 7a는 HCA가 아닌 CDCA가 시험관내에서 FXR 신호전달을 활성화시킨다는 것을 입증하는 실험 결과를 도시한다. hFXR 루시퍼라제 세포 리포터 분석에서, 선택된 담즙산 단독의 용량 반응 곡선은 FXR 신호전달에 대한, CDCA의 전체 효능제 활성, LCA 및 DCA의 낮은 효능제 활성(시험된 최대 농도는 100 μM) 및 히포콜산의 효능제 활성 없음(HCA; 최대 200 μM)을 나타낸다.
도 7b는 시험관내 FXR 활성화 검정에 기초하여 루시퍼라제에서 50 μM CDCA(도 7a에 도시된 바와 같이 CDCA = 50 μM의 EC50)의 존재하에 히오콜산(HCA)에 의한 FXR의 상승작용 활성화를 입증하는 실험 결과를 도시한다. DCA 및 LCA는 HCA와 상당한 상승 효과를 나타내지 않았다. 100 μM에서의 LCA와 50 μM에서의 CDCA는 세포에 대한 독성 증가로 인해 활성화 배수에 차이가 없음을 보여주었다. 데이터는 50 μM CDCA 단독에 대한 배수 변화로 표현된다.
도 8a 및 8b는 원발성 경화성 담관염(PSC) 환자에서 총 담즙산 수준 및 담즙산 조성물의 변화를 보여주는 실험 결과를 도시한다. 도 8a:환자는 총 관문 혈액 및 말초 혈액 담즙 수준의 상응하는 증가와 함께 담즙의 총 담즙산 수준이 감소된 것으로 나타났다. 도 8b:PSC 환자는 소화관 미생물군집에 의해 전형적으로 생성된 이차 및 접합된 이차 담즙산의 비율이 감소하고, 상응하는 업스트림 접합된 일차 담즙산이 유의미하게 증가함을 보여준다. 담즙산 농도는 정량화를 위한 적절한 참조 표준으로 LC-MS를 사용하여 측정하였다. 데이터는 평균 ± 표준 편차로 표시된다. * Tukey의 다중 비교 테스트를 통한 양방향 Anova를 기반으로 한, PSC와 건강한 환자의 유의미한 차이를 나타낸다. P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001.
도 9a~9g는 DDC-식이 유도 담즙정체성 질환으로 치료된 종래에 하우징된 마우스가 건강한 대조군과 비교하여 변경된 담즙산 함량 및 소화관 미생물 프로파일을 나타내는 실험 결과를 보여준다. 도 9a:알칼리성 포스파타제(ALP), 알라닌 아미노기전달효소(ALT), 총 빌리루빈(TBIL) 및 콜레스테롤(CHOL)을 포함하여 DDC 처리된 종래에 하우징된 스위스 알비노 마우스에서 혈청 바이오마커의 수준이 상당히 증가하여 담즙정체성 간 질환의 존재를 확인했다. 도 9b-9d:DDC-다이어트 유도된 담즙정체성 질환이 있는 마우스는 처리되지 않은 대조군과 비교하여 업스트림 접합된 1º 담즙산의 상응하는 증가와 함께 2º 및 접합된 2º 담즙산의 수준이 감소된 것으로 나타났다. 도 9e:알파 다양성 및 베타 다양성 지수는 담즙정체성 질환을 유도하기 위해 마우스 DDC 처리전(d0) 및 처리후(d21) 마우스에서 뚜렷한 미생물 모집단을 보여준다. 알파 다양성(좌측 그래프)은 Shannon 다양성 지수에 기초한 종 풍부도의 측정치이며, 베타-다양성(우측 그래프)은 원리 좌표 분석(PCoA)을 기반으로 2개의 가중 축에서 분리 거리로 표시된다. 도 9f:담즙정체성 질환을 유발하기 위해 DDC로 처리전(d0) 및 처리후(d21) 마우스간에 유병률(p ≤ 0.2)이 상당히 상이한 종의 목록.도 9g:기존의 스위스 알비노 마우스에서 담즙정체성 질환 진전과 함께 알려진 7α-디하이드록실화 활성으로 균주의 상당한 손실.*는 DDC 처리된 및 대조군 마우스(A~D) 사이 또는 마우스 DDC 처리전(d0) 및 처리후(d21) 마우스간에 유의한 차이를 나타낸다. Tukey의 다중 비교 테스트를 통해 양방향 Anova를 기반으로 하는 유의성 분석.P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001
도 10a~10e는 소화관 미생물군집의 부재가 스위스 알비노 마우스에서, 마우스-유래 FMT에 의한 군집화에 의해 역전될 수 있는 병태인 DDC-식이 유도 담즙정체성 질환에 대한 감수성을 증가시킨다. 무균(GF) 마우스는 보다 빠른 체중 감소(도 10a) 및 DDC 식이로 처리할 때 종래에-하우징된(CH) 마우스와 비교된, 알칼리성 포스파타제(도 10b), 알라닌 아미노기 전달효소(도 10c) 및 총 빌리루빈(도 10d)과 같은 혈청 바이오마커의 수준이 훨씬 더 높음을 나타낸다. GF 마우스에서 스위스 알비노 마우스-유래된 자가-FMT로 4주 동안의 군집화는 체중 감소 및 ALP, ALT 및 TBIL의 수준이 DDC-식이가 주어진 CH 마우스에 비교할만한 수준으로 감소된, DDC-유도된 질환에 대한 이러한 감수성을 역전시킨다. 도 10e는 담즙산 프로파일링의 결과를 보여주며, 이는 FMT 처리가 무균 마우스와 비교하여 소화관에서 담즙산 조성물을 회복시키기에 충분하다는 것을 결정하였다. *는 DDC 처리에서 GF 마우스에 비해 유의한 차이를 나타낸다. Tukey의 다중 비교 테스트를 통해 양방향 Anova를 기반으로 하는 유의성 분석.P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001
도 11a~11e는 미생물 조성물이 DDC-식이 유도된 담즙정체성 간 질환에 대한 감수성에 영향을 준다는 것을 보여준다. 도 11a~11b:무균 C57Bl/6 및 스위스 알비노 마우스는 질환에 대한 종래의 스위스 알비노 마우스의 상당한 저항에도 불구하고 간 질환으로 인한 체중 감소에 비교할만한 감수성을 나타낸다. 도 11c:DDC 식이에서, 종래의 C57Bl/6 공여체 마우스 FMT를 갖는 무균 스위스 알비노 마우스의 군집화는 종래의 스위스 알비노 공여체 마우스로부터 FMT를 받는 스위스 알비노 마우스보다 더 신속한 체중 감소를 초래한다. 도 11d:혈청 ALP 수준은 말단 수집 전 체중 감소의 차이에도 불구하고, 상이한 공여체로부터 FMT로 군집화된 마우스 사이에서 비교할만하게 유지된다. 도 11e:C57Bl/6 공여체 FMT 군집화된 마우스는 스위스 알비노 공여체 FMT 군집화된 마우스와 비교하여 상당히 더 높은 수준의 1º 담즙산 및 더 낮은 수준의 2º 담즙산을 갖는다. (*참고로, 도 11a의 경우, GF-C57 마우스는 다른 3개의 아암과는 별도의 실험의 일부였다. )
도 12a~12c는 미생물군집의 복원이 무균 마우스의 DDC 식이 유도 간 질환에 대한 감수성을 구제한다는 것을 보여준다. 복잡한 종래의 스위스 알비노 마우스 유래 FMT, 또는 담즙산 대사(Max BA)를 회복시키는 덜 복잡한 설계된 조성물에 의한 처리가 무세균 스위스 알비노 마우스에서 DDC 식이에 대한 반응으로 체중 감소(도 12a) 및 ALP 수준(도 12b)을 감소시켰다. 도 12c:종래의 마우스 유래된 FMT 또는 설계된 조성물(Max BA)에 의한 군집화는 무균 마우스에서 배설물 담즙산 서브셋의 대부분을 회복시켰다. *는 DDC 처리에서 GF 마우스에 비해 유의한 차이를 나타낸다. Tukey의 다중 비교 테스트를 통해 양방향 Anova를 기반으로 하는 유의성 분석.P-값은 하기와 같다:* p≤0.1, ** p ≤ 0.01, *** p≤0.001 **** p ≤ 0.0001
도 13은 이차 담즙산(데옥시콜산 + 리토콜린산)에 의한 식이 보충의, DDC-식이 유도 담즙정체성 질환에 대한 감수성에 대한 유익한 효과를 입증한다. DCA + LCA 보충된 식이의 무균 스위스 알비노 마우스는 DDC 식이에 노출되었을 때 미처리 무균 마우스에 비해 체중 감소율이 감소된 것으로 나타났다.
도 14는 BSH 활성의 생체 정보 예측을 시험관내 분석된 활성과 비교한 결과를 보여주는 그래프 및 표의 세트이다.
도 15는 7α-디하이드록실화 활성의 생체 정보 예측을 시험관내 분석된 활성과 비교한 결과를 나타내는 그래프 및 표이다.
도 16은 본 발명의 다양한 조성물 및 방법에 유용한 예시적인 박테리아로부터의 전장 16S rDNA 서열의 목록이다.
본 발명은 담즙정체성 질환의 예방, 개선 및 치료에 사용하기 위한 방법 및 조성물을 제공한다. 본 발명의 방법에 따르면, 치료된 대상체의 미생물군집은 본 명세서에 기재된 조성물과 같은 박테리아 조성물의 투여에 의해 담즙산 대사에 영향을 미치도록 변경된다. 일부 구현예에서, 박테리아 조성물은 약제와 조합하여 사용된다. 일부 구현예에서, 조성물과 함께 투여될 때 약제학적 투약량 또는 요법은 약제학적 단독 치료에 비해 양이 감소된다. 일부 구현예에서, 약제의 효능은 본 발명의 조성물로 치료함으로써 증가되고/되거나 부작용이 감소된다.
위장관에서의 미생물군집 매개된 담즙산 대사는 접합된 일차 담즙산의 탈접합을 포함하는데, 이 과정에서 극성 타우린 또는 글리신 그룹이 접합된 일차 담즙산염에서 제거되어 일차 담즙산이 생성된다(Ridlon 등, J. Lipid Res. 47:247-259, 2006). 접합된 일차 담즙산염의 농도 감소는 환자가 바람직하지 않은 수준의 접합된 담즙산을 갖는 담즙정체성 질환의 효과 및/또는 진행에 상당히 영향을 줄 수 있다. 게다가, 조성물은 예를 들어 상피 세포, 면역 세포 및 간에서 신호전달 특성을 갖는 일차 및/또는 이차 담즙산의 수준 증가로 인해 추가 효과를 유발할 수 있다. 담즙산 경로를 조작하는 것은 OCA가 담즙정체성 환자에게 치료적 이점이 있을 수 있다는 보고에 의해 입증된 바와 같이 치료적 이점을 가질 수 있다. 하기에 기재된 바와 같이, 일부 구현예에서, 본 발명의 조성물은 적어도 하나의 담즙산염 가수분해효소(BSH)를 발현할 수 있는 하나 이상의 박테리아 종 또는 OTU를 포함한다.
일차 담즙산은 접합된 일차 담즙산염의 탈접합 생성물이다. 일차 담즙산의 예는 콜산(CA) 및 케노데옥시콜산(CDCA)이다. CA 및 CDCA는 간에서 담즙산 생성을 조절하는 핵 호르몬 수용체인 파르네소이드 X 수용체(FXR)에 대한 리간드이다. FXR은 담즙산 합성 효소 CYP7A1 및 CYP8B1을 하향조절함으로써 담즙산 항상성을 조절한다(Sinal 등, Cell 102:731-744, 2000). FXR 신호전달의 활성화는 담즙산 합성을 억제하고, 간으로부터 담즙산 배출을 증가시켜, 잠재적으로 독성 담즙산에 의한 간 축적 및 간 손상을 감소시킨다(Chiang, Compr.Physiol. 3:1191-1212, 2013). 담즙산 합성의 감소는 간에서 직접적으로 및 FXR-FGF15/19-FGF4R 경로에 의해 위장관을 통해 간접적으로 매개될 수 있으며, 이 둘 모두는 담즙산 신호전달에 의해 매개된다. FGF19는 쥣과 FGF15의 인간 오쏘로그이다. FXR 신호전달은 또한 NF-kB 신호전달에 대한 그의 작용을 통해 항-염증 성분을 갖는 것으로 여겨진다(Chiang, Compr.Physiol. 3:1191-1212, 2013). 핵 호르몬 수용체 FXR(NR1H4)을 표적으로 하는 분자는 담즙정체성 간 질환, 예를 들어 OCA를 치료하기 위해 개발되고 있다. 따라서, 일부 구현예에서, 본 발명의 조성물 및 방법은 접합된 일차 담즙산염을 일차 담즙산으로 대사작용할 수 있고, 선택적으로 또한 일차 담즙산을 이차 담즙산으로 대사작용할 수 있는 하나 이상의 박테리아를 포함하는 조성물에 관한 것이다.
일부 구현예에서, 콜산 (CA) 및 케노데옥시콜산 (CDCA)과 같은 미생물군집 합성된 일차 담즙산은 FXR에 대한 일차 내인성 리간드이고, 따라서 접합된 일차 담즙산의 농도를 감소시키고, 이들의 합성에서 중요한 역할을 한다. 생성된 일차 및 이차 담즙산은 접합된 담즙산의 간 축적뿐만 아니라 잠재적으로 독성인 담즙산으로부터의 손상을 방지하는 기능을 할 수 있다. 따라서, 본 발명은 회장 및 간에서 내인성 신호전달에 영향을 주는 표적화된 경로를 따라 담즙산 대사를 변경시키는, 설계된 조성물을 포함하는 박테리아 조성물을 제공한다. 본 발명의 조성물 및 방법은 하기와 같이 더욱 상세하게 기재된다.
조성물
본 발명의 조성물은 건강한 포유동물, 예를 들어 인간의 위장관에서 확인된 미생물, 예를 들어 박테리아를 포함한다. 일부 구현예에서, 조성물에 유용한 박테리아의 유형은 소장(예를 들어, 인간 소장)에서 확인된 유형이다. 일부 경우에는, 박테리아의 유형이 주로 결장에서 확인되는 것이다. 일부 구현예는 박테리아(예를 들어, 소장 및 결장 유래 박테리아)의 혼합된 모집단을 포함한다. 일부 경우에, 본 조성물은 배설물 제제, 예를 들어 인간 배설물로부터 직접 유래된 제제로부터 유래된다. 인간 배설물로부터 "직접 유래된"은 조성물의 박테리아가 상기 박테리아의 배양이 거의 또는 전혀없이 인간 배설물로부터 단리됨을 의미한다.
일부 구현예에서, 본 조성물은 단일 종 무균 배양에서 유래된 박테리아를 포함한다. 이러한 배양물로부터 선택된 종은 조합되어 조성물을 생성한다. 이러한 조성물은 본 명세서에서 "설계된 조성물"로 지칭된다. 일부 경우에, 배양 물로부터의 박테리아는 포자를 형성하도록 유도되고, 이러한 포자는 조성물에 사용된다. 설계된 조성물의 박테리아는 일반적으로 건강한 인간 배설물에서 확인된 종이다. 설계된 조성물의 예는 하기에 기재되어 있다.
일부 구현예에서, 본 조성물은 타우린 및/또는 글리신 접합을 제거함으로써 하나 이상의 접합된 일차 담즙산염을 일차 담즙산으로 대사작용할 수 있는 박테리아 및/또는 가수분해, 산화, 환원, 하이드록실화, 에피머화, (일련의 CoA-결찰, 산화 및/또는 탈수 반응을 통한) 7-알파-디하이드록실화, 탈황산화 및 담즙산의 이량체화를 통해 하나 이상의 일차 담즙산을 이차 담즙산으로 대사작용할 수 있는 박테리아를 포함한다. 예를 들어, 본 발명의 특정 조성물은 담즙산염 가수분해효소(BSH) 활성을 발현할 수 있는 박테리아를 포함하므로, 예를 들어 위장관내에서 접합된 일차 담즙산염의 탈접합을 증가시키는 데 사용될 수 있다. 다른 조성물은 담즙산염 가수분해효소 활성뿐만 아니라 담즙산화 및 7-알파-디하이드록실화를 포함한 활성을 갖는 박테리아를 포함한다. 담즙산에서 원하는 변경을 달성하기 위해, 특정 기능을 발현할 수 있는 박테리아가 선택될 수 있다. 예를 들어, 박테리아는 기능성 BSH, 7α-디하이드록실라제, α-하이드록시스테로이드 탈수소효소 (α-HSDH), β-하이드록시스테로이드 탈수소효소, 또는 담즙산을 대사시킬 수 있는 다른 효소를 발현하는 능력으로 선택될 수 있다. 일부 경우에, 활성은 하나 초과의 특정 활성, 예를 들어, 7α-디하이드록실화 를 갖는 오페론에 의해 영향을 받아, 하이드록실 담즙산의 디하이드록시 담즙산으로의 대사를 초래한다. 박테리아 또는 박테리아의 조합은, 예를 들어 하나 이상의 접합된 일차 담즙산염(예를 들어, 글리코콜산, 타우로콜산, 글리코케노데옥시콜산, 타우로케노데옥시콜산, 타우로-α-무리콜산, 또는 타우로-b-무리콜산)의 양을 감소시키는 그의 능력으로 선택된다. 일부 구현예에서, 박테리아 또는 박테리아의 조합은 하나 이상의 일차 또는 이차 담즙산(예를 들어, 콜산, 데옥시콜산, 옥소콜산(3-, 7- 또는 12-), 이소콜산, 케노데옥시콜산, 리토콜린산, 옥소케노데옥시콜산 (3- 또는 7-), 이소코네데옥시콜산, α-무리콜산, β-무리콜산, γ-무리콜산(히아콜산으로도 알려져 있음)의 양을 감소 또는 증가시키는 능력으로 선택된다. 담즙산은 본 명세서에 기재된 바와 같이 LC-MS를 사용하여 분석될 수 있으며, 당해 분야에 공지된 박층 크로마토그래피, GC-질량 분광분석법 또는 당해 분야에 공지된 다른 방법으로 공지되어 있다.
본 명세서에 기재된 조성물은 일반적으로 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 45, 또는 50가지 유형의 박테리아를 포함한다. 박테리아 유형은 가족, 속, 분기군, 종 또는 균주일 수 있다. 일 예에서, 조성물은 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 45, 또는 50개의 상이한 박테리아 종을 포함한다. 또 다른 예에서, 조성물은 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개의 상이한 분기군으로부터의 박테리아를 포함한다. 보다 구체적인 예에서, 조성물은 표 1, 표 2, 또는 표 3의 일부 B 또는 C로부터의 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 45, 또는 50개의 상이한 종; 또는 표 1에 열거된 분기군 각각의 분기군의 적어도 5, 10, 15 또는 18개 모두에서의 종을 포함한다:1, 6, 86, 87, 90, 100, 101, 164, 195, 196, 197, 203, 204, 및 297.일부 구현예에서, 박테리아 종은 참조 서열 (예를 들어, 16S rDNA 서열)에 대한 상동성에 의해 확인된다. 일반적으로, 종의 참조 서열의 16S rDNA 서열(전체 서열 또는 가변 영역(들), 예컨대 V4 또는 V1~3)에 대해 적어도 97% 동일성(예를 들어, 적어도 98%, 적어도 99% 또는 100% 동일성)을 갖는 박테리아 균주는 참조 종과 동일한 종이다. 이러한 참조 서열의 예시적인 목록이 도 16에 제공되어 있다. 일부 구현예에서, 조성물 중 상이한 OTU 또는 종의 수는 60, 50, 30, 20 또는 15 미만이다. 전형적으로, 조성물은 약제학적으로 허용가능한 부형제로 제형화된다(하기 참조).
본 명세서에 기재된 본 발명의 목적을 위해, 분기군은 진화론적으로 관련된 박테리아 종의 그룹이다. 이들의 관련성 때문에, 분기군 내의 박테리아는 담즙산 대사와 같은 기능적 특징을 공유할 가능성이 평균보다 더 높다. 분기군은 계통발생학 분야의 통상의 기술을 갖는 개체에게 친숙한 최대 가능성 방법을 사용하여 전장 16S 서열로 구성된 계통발생수의 위상기하학을 기반으로 정의된다. 주어진 분기군의 모든 OTU가 하기를 보장하도록 분기군이 구성된다:(i) 서로 지정된 수의 부트스트랩 지원 노드 내에서, 및 (ii) 5%의 유전적 유사성 내에서. 동일한 분기군 내에 있는 OTU는 16S-V4 서열 데이터에 기초하여 상이한 분기군에서 OTU와 유전자적 및 계통발생적으로 구별되는 것으로 구별될 수 있는 반면, 동일한 분기군 내에 속하는 OTU는 밀접하게 관련되어 있다. 하나의 종 또는 OTU를 동일한 분기군으로부터의 또 다른 종 또는 OTU로 치환하는 조성물은 생태학적 기능을 보존할 가능성이 있으므로 본 발명에 유용하다. 일부 구현예에서, 본 발명에 유용한 박테리아는 당 업계에 공지되고, 본원에 예시된 바와 같이 특정 기능 및 추가의 시험을 나타내는 것으로 입증된 하나 이상의 박테리아를 함유하는 분기군에서의 존재에 기초하여 선택될 수 있다. 일부 구현예에서, 본 조성물은 표 1에서 5개, 10개, 15개 또는 모든 18개의 분기군으로부터 1종, 2종 또는 3종을 포함한다. 분기군 내의 종의 예시적인 목록이 표 2에 제공되어 있다. 표 3은 상이한 박테리아 종의 목록 및 각각의 담즙산 대사 활성의 지표이다. 본원에 표 3으로부터의 종이 본 발명의 조성물 또는 제형에 포함되는 것으로 표시될 때, 임의로 상기 종은 표 3에 언급된 하나 이상의 표시된 담즙 대사 활성을 포함한다. 또한 분기군을 기준으로 관련 유기체를 선택한 다음, 표 3의 박테리아를 확인하는 데 사용된 방법에 따라 원하는 활성을 테스트하여 조성물이 확인될 수 있다. 표 3에서, 블랭크 세포는 상응하는 균주에서 시험되지 않은 활성을 나타낸다.
일부 구현예에서, 조성물의 모든 유기체는 절대 혐기성 미생물이다. 일부 구현예에서, 조성물 중 박테리아는 시험관내에서 배양되어 포자를 형성할 수 있는 종이며, 이러한 포자는 시험관내에서 발아될 수 있다. 일부 구현예에서, 조성물 중 박테리아는 포자이다. 일부 구현예에서, 조성물 중 박테리아는 영양 형태이다. 박테리아 포자의 조성물 또는 영양 박테리아의 조성물은 대부분의 박테리아가 특정 형태(즉, 포자 또는 영양)인 반면, 소수는 상이한 형태, 예를 들어, 포자의 경우, 조성물 내의 일부 세포는 영양일 수 있지만, 영양 박테리아의 경우 일부 세포는 포자의 형태일 수 있음을 이해해야 한다. 예를 들어, 본 조성물은 100%, 적어도 99%, 적어도 97%, 적어도 95%, 적어도 90%, 적어도 85%, 적어도 80%, 또는 적어도 75%의 포자일 수 있거나 또는 본 조성물은 100%, 적어도 99%, 적어도 97%, 적어도 95%, 적어도 90%, 적어도 85%, 적어도 80%, 또는 적어도 75% 영양 박테리아일 수 있다. 일부 구현예에서, 개별 종은 영양 박테리아 및 포자의 혼합물로서 존재한다. 일부 구현예에서, 조성물에 사용된 종의 수는 콜로니-형성 단위(cfu) 검정을 사용하여 결정되지만, 당해 분야에서 공지된 다른 방법이 사용될 수 있다. 영양 또는 포자 특이적 형태의 박테리아 백분율의 평가는 투약 형태의 조성물을 제조한 날짜 또는 투약 형태의 날짜 또는 투여로 언급될 수 있다. 포자를 제조하는 방법은 당 업계, 예를 들어 미국특허 제9,011,834호에 기재되어 있다.
치료에 효과적인 박테리아의 총 수는 건강한 인간의 위장관에서 유기체의 총 수보다 훨씬 적으며, 즉, 조성물에서 제공되는 종의 다양성뿐만 아니라 제공된 총 유기체의 수의 관점에서 치료적 효과를 달성하기 위해 완전한 건강한 미생물군집을 투여할 필요는 없다.
본 출원에서 조성물이 특정 유형의 박테리아로 "구성되는" 것으로 표시되는 경우, 이는 조성물에 존재하는 박테리아 유형만을 지칭하는 것으로 이해되어야 한다. 특정 박테리아 목록을 "구성하는" 박테리아 제형은 추가의 비-박테리아 물질, 예컨대 하나 이상의 부형제(예를 들어, 하나 이상의 캡슐 포함), 수성 또는 비-수성 매질(예를 들어, 글리세롤, 폴리에틸렌 글리콜, 코코아 버터, 물 및/또는 완충액), 뿐만 아니라 하나 이상의 프리바이오틱스 또는 소분자 약물을 함유할 수 있다.
동일성의 결정
일부 구현예에서, 분기군, 조작상 분류 단위(OTU), 종 및 균주는 16S rDNA 서열 (들)에 의해 확인된다. 분기군, OTU, 종 및 균주의 관련성은 분기군, OTU, 종 또는 균주 간의 동일성 퍼센트에 의해 결정될 수 있다. 일부 경우에, 동일성 퍼센트는 16S rDNA 서열을 사용하여 결정된다. 16S rDNA 서열은 전장, 하나 이상의 가변 영역일 수 있고, 단일 서열로부터 유래되거나, 또는 균주, 종 또는 OTU로부터의 다수의 16S rDNA 서열로부터 유래된 복합체일 수 있다. 참조 서열과 쿼리 서열 사이의 동일성 퍼센트는 당해 분야에 공지된 방법을 사용하여 결정될 수 있다. 이러한 결정을 위한 방법의 비-제한적인 예가 아래에 제공된다. 본 명세서에 사용된 바와 같이, 2개의 뉴클레오타이드 서열 사이의 관련성은 파라미터 "동일성"에 의해 기재된다. 일반적으로, 2개의 박테리아는 그들이 적어도 95%, 예를 들어 97%, 98%, 99% 또는 100%의 16S rDNA 동일성을 갖는 경우 동일한 OTU 또는 종이다. 일부 구현예에서, 16S rDNA 동일성은 전장 16S rDNA 분자에 대해 결정된다. 일부 구현예에서, 16S rDNA 동일성은 가변 영역(예를 들어, V4)과 같은 16S rDNA 분자의 단편에 대해 결정된다. 일부 구현예에서, 동일성은 예를 들어 적어도 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 75, 100, 125, 150, 175, 200, 225, 250, 300, 또는 그 초과 개의 뉴클레오타이드의 단편에 대해 결정된다(또는 본원에 열거된 임의의 수 사이의 범위, 또는 이러한 범위의 특정 값).
일 구현예에서, 쿼리 서열과 참조 서열 사이의 서열 동일성의 정도는 1) 디폴트 스코어링 매트릭스 및 디폴트 갭 페널티를 사용하여 임의의 적합한 정렬 프로그램에 의해 2개의 서열을 정렬하고, 2) 정확한 매치의 수를 확인하고, 여기서 정확한 매치는 정렬 프로그램이 정렬의 주어진 위치에서 2개의 정렬된 서열에서 동일한 뉴클레오타이드를 확인한 경우이며, 3) 정확한 매치의 수를 참조 서열의 길이로 나눔으로써 결정된다.
또 다른 구현예에서, 쿼리 서열과 참조 서열 사이의 서열 동일성의 정도는 1) 디폴트 스코어링 매트릭스 및 디폴트 갭 페널티를 사용하여 임의의 적합한 정렬 프로그램에 의해 2개의 서열을 정렬하고, 2) 정확한 매치의 수를 확인하고, 여기서 정확한 매치는 정렬 프로그램이 정렬의 주어진 위치에서 2개의 정렬된 서열에서 동일한 뉴클레오타이드를 확인한 경우이며, 3) 정확한 매치의 수를 2개의 서열 중 가장 긴 길이로 나눔으로써 결정된다.
또 다른 구현예에서, 쿼리 서열과 참조 서열 사이의 서열 동일성 정도는 1) 디폴트 스코어링 매트릭스 및 디폴트 갭 페널티를 사용하여 임의의 적합한 정렬 프로그램에 의해 2개의 서열을 정렬하고, 2) 정확한 매치의 수를 확인하고, 여기서 정확한 매치는 정렬 프로그램이 정렬의 주어진 위치에서 2개의 정렬된 서열에서 동일한 아미노산 또는 뉴클레오타이드를 확인한 경우이며, 3) 정확한 매치의 수를 서열의 갭 및 돌출 부분을 포함하는 전체 정렬의 길이인, “정렬 길이”로 나눔으로써 결정된다.
서열 동일성 비교는 일반적으로 서열 비교 프로그램의 도움으로 이루어진다. 이러한 상업적 또는 공개적으로 이용가능한 컴퓨터 프로그램은 복잡한 비교 알고리즘을 사용하여 둘 이상의 서열 사이의 차이를 초래할 수 있는 진화론적 사건을 가장 잘 반영하는 둘 이상의 서열을 정렬시킨다. 따라서, 이들 알고리즘은 동일하거나 유사한 아미노산의 정렬을 보상하고 갭, 갭 연장 및 비-유사 아미노산의 정렬을 페널티하는 평점 체계로 동작한다. 비교 알고리즘의 평점 체계는 하기를 포함한다:
i) 갭이 삽입될 때마다 페널티 점수 배정(갭 페널티 점수)
ii) 기존 갭이 추가 위치로 연장될 때마다 페널티 점수 배정(연장 페널티 점수)
iii) 동일한 아미노산의 정렬시 높은 점수의 배정, 및
iv) 동일하지 않은 아미노산의 정렬시 가변 점수의 배정.
일반적으로 정렬 프로그램의 디폴트 값은 서열 비교에 사용된다. 동일성을 결정하는데 유용한 적합한 컴퓨터 프로그램은 예를 들어 BLAST (blast.ncbi.nlm.nih.gov)를 포함한다.
본 발명의 일 구현예에서, 정렬 프로그램은 선택된 서열의 전장, 예를 들어 전장, V1-3, V4 또는 V6 16S rDNA 서열에 대한 정렬을 최적화한다. 16S rDNA 서열은 선택된 균주, 종 또는 OTU로부터의 단일 서열 또는 다수의 16S rDNA 서열의 복합체일 수 있다. 예를 들어, 전반적인 정렬 프로그램은 Needleman-Wunsch 알고리즘 (Needleman and Wunsch, J. Mol. Biol. 48: 443-453, 1970)을 기반으로 한다. 이러한 프로그램의 비-제한적인 예는 ebi.ac.uk/Tools/psa/에서 이용가능한 EMBOSS Needle 및 EMBOSS Stretcher 프로그램이다.
일 구현예에서, 서열은 전반적인 정렬 프로그램에 의해 정렬되고, 서열 동일성은 프로그램에 의해 확인된 정확한 매치의 수를 "정렬 길이"로 나눈 값을 확인함으로써 계산되며, 여기서 정렬 길이는 서열의 갭 및 돌출부분을 포함하는 전체 정렬의 길이이다. 추가 구현예에서, 전반적인 정렬 프로그램은 Needleman-Wunsch 알고리즘을 사용하고, 서열 동일성은 프로그램에 의해 확인된 정확한 매치의 수를 "정렬 길이"로 나눈 값을 확인함으로써 계산되며, 여기서 정렬 길이는 서열의 갭 및 돌출부분을 포함하는 전체 정렬의 길이이다.
또 추가의 구현예에서, 전반적인 정렬 프로그램은 EMBOSS 바늘 및 EMBOSS 스트레처(stretcher)로 구성된 군으로부터 선택되고, 서열 동일성은 프로그램에 의해 확인된 정확한 매치의 수를 "정렬 길이"로 나눈 값을 확인함으로써 계산되며, 여기서 정렬 길이는 서열의 갭 및 돌출부분을 포함하는 전체 정렬의 길이이다.
소프트웨어가 정렬을 생성하면, 유사성 퍼센트(%) 및 서열 동일성 퍼센트(%)를 계산할 수 있다.
제형
일부 구현예에서, 치료는 대상체, 예를 들어, 담즙정체성 질환 또는 병태에 대해 위험이 있거나, 최근에 치료받았거나, 진단된 환자에게 조성물을 투여하는 단계를 포함한다. 일부 구현예에서, 조성물은 경구 투약 형태이다. 일부 구현예에서, 조성물은 활성 성분으로서 본 명세서에 기재된 바와 같은 박테리아 컨소시엄을 하나 이상의 약제학적으로 허용가능한 담체(부형제)와 조합하여 포함한다. 본 발명의 조성물을 제조함에 있어서, 박테리아는 전형적으로 부형제와 혼합되거나, 부형제에 의해 희석되거나, 예를 들어 캡슐, 샤세트, 종이 또는 다른 컨테이너의 형태로 이러한 담체 내에 봉입된다. 부형제가 희석제로서 작용할 때, 이는 고체, 반고체 또는 액체 물질일 수 있으며, 이는 활성 성분을 위한 비히클, 담체 또는 매질로서 작용한다. 따라서, 제형은 예를 들어 최대 10중량%의 활성 성분, 연질 캡슐, 경질 캡슐, 겔-캡, 정제, 좌제, 용액 또는 포장된 분말을 함유하는, 정제, 환제, 산제, 로젠지, 샤세트, 캬셰, 엘릭시르, 현탁액, 에멀션, 용액, 시럽, 에어로졸(고체로서, 또는 액체 배지내)의 형태로 있을 수 있다. 적합한 부형제는 예를 들어 PBS, 글리세롤, 코코아 버터 또는 폴리에틸렌 글리콜을 포함한다.
제형을 제조할 때, 다른 성분과 배합하기 전에 적절한 입자 크기를 제공하기 위해 고체 형태의 조성물이 밀링될 수 있다. 또한, 조성물은 당해 분야에 공지된 방법 및 형태를 사용함으로써, 예를 들어 결장에서 방출하기 위해 환자에게 투여한 후 활성 성분의 신속, 지속 또는 지연 방출을 제공하도록 제형화될 수 있다.
조성물은 단위 투여 형태로 제형화될 수 있고, 각각의 투여 형태는 약 102 내지 약 109 생존가능한 OTU, 예를 들어, 약 104 내지 약 108 OUT를 함유한다. 일부 구현예에서, 실질적으로 모든 박테리아는 포자 형태이다. 일부 구현예에서, 박테리아는 포자 및 영양 형태이다. 용어 "단위 투약 형태"는 인간 대상체 및 다른 포유동물에 대한 일원화된 투약량으로서 적합한 물리적 이산 단위를 지칭하며, 각각의 단위는 적합한 약제학적 부형제와 관련하여 원하는 치료적 효과를 생성하도록 계산된 사전결정된 양의 활성 성분을 함유한다. 일부 경우에, 둘 이상의 단위 투약 형태는 용량을 구성한다. 예를 들어, 단일 용량은 1개의 단위 투약 형태, 2개의 단위 투약 형태, 3개의 단위 투약 형태, 4개의 단위 투약 형태, 5개의 단위 투약 형태 이상일 수 있다. 일부 경우에, 단일 용량을 구성하는 단위 투약 형태의 수는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 또는 30개의 단위 투약 형태이다. 단일 용량은 예를 들어 103 내지 약 109 포자, 예를 들어, 약 104 내지 약 108 포자일 수 있다. 한 예에서, 용량은 용량에 총 102 및 108 포자를 함유하는 1, 2, 3 또는 4개의 캡슐이다. 다중 투약 형태를 갖는 단일 용량의 경우, 투약 형태는 일반적으로 규정진 기간 내에, 예를 들어 1시간, 2시간, 5시간, 10시간, 15시간 또는 24시간 내에 전달된다.
본 명세서에 기재된 조성물은 넓은 투약 범위에 걸쳐 효과적일 수 있고, 일반적으로 약제학적 유효량으로 투여된다.
본 명세서에 기재된 조성물을 포함하는 정제 또는 환제는, 투약 형태를 제공하기 위해, 예를 들어, (예를 들어, 삼킴능력을 개선함으로써) 전달을 용이하게 하기 위해, 또는 위장관, 예컨대 결장의 표적화된 영역으로의 전달을 개선하기 위해 코팅 또는 달리 배합될 수 있다.
일부 구현예에서, 정제 또는 환제는 조성물을 둘러싸는 내부 성분 및 외부 성분을 포함하며, 외부 성분은 내부 성분에 대한 외피 역할을 한다. 두 성분은 위내 붕해에 저항할 수 있고 내부 성분이 십이지장 내로 온전하게 통과하거나 방출 지연되는 장용 코팅층에 의해 분리될 수 있다.
일부 구현예에서, 본 발명의 조성물을 포함하는 제형은 내시경술 또는 원하는 부위, 예를 들어, 상부 장관(예를 들어, 위 및/또는 십이지장) 또는 하부 장관(예를 들어, 소장 및/또는 대장) 또는 근처에서 제형을 전달하는 다른 적합한 방법에 의해, 비위 경로를 통해 투여된다. 시험관내 또는 동물 모델 시험 시스템으로부터 또는 임상 연구로부터 유래된 용량-반응 곡선으로부터 효과적인 용량이 외삽될 수 있다.
게다가, 제형은 선택적으로 당해 기술에 공지된 제산제와 조합하여 투여될 수 있다.
치료 방법
본 명세서에 기재된 바와 같은 조성물은 예를 들어 담즙정체성 질환 또는 병태를 예방 또는 치료하기 위해 투여하기 위해, 대상체, 예를 들어, 포유동물, 예컨대 치료가 필요한 인간에게 투여하기에 유용하다. 이러한 질환의 예는 일반 담즙정체증(GC), 원발성 경화 담관염(PSC), 원발 담도 담관염(PBS), 진행성 가족성 간내 담즙정체증(PFIC), 비-알코올성 지방간 질환(NAFLD), 비-알코올성 지방간염(NASH), 임신 담즙정체증, 담관염, 간염, 알코올성 간 질환, 간세포 암종, 간경변증, 낭포성 섬유증 및 이식편 대 숙주 질환(GVHD)을 포함한다. 또한, 예를 들어 담석, 염증성 협착증, 암 또는 췌장염으로 인한 간외 담관의 막힘이 있는 대상체는 본 발명의 방법에 의해 치료될 수 있다. 예를 들어, BSH, 7α-디하이드록실화 및 하이드록시스테로이드 수소이탈 활성(낮은 활성을 갖는 기준과 비교하여 상승된 활성)을 제공할 수 있는 Max BA 활성 조성물은, 비정상 담즙산 조성물, 예를 들어 접합된 일차 담즙산의 비정상 축적을 나타내는 담즙정체성 질환 환자를 치료하는데 사용될 수 있다.
일부 구현예에서, OCA 및/또는 UDCA 치료에 반응하지만 바람직하지 않은 부작용(예를 들어, 중증(불내성) 소양증, 간-관련 부작용의 상승 및/또는 OCA 치료와 연관된 생화학적 테스트, 또는 바람직하지 않은 HDL-C 감소)을 경험하는 환자는 BSH 단독 조성물, 또는 적어도 BSH 활성을 갖는 본 명세서에 기재된 다른 조성물로 처리될 수 있고, 이에 의해 OCA 및/또는 UDCA의 투여량 또는 투여 빈도의 감소를 허용하고; 또는 정상 또는 고용량의 OCA 및/또는 UDCA에 대한 환자의 내성을 증가시킨다. 특정 이론을 고수하지 않으면서, 그러한 환자에서 담즙산의 수준을 변경함으로써, CDCA와 같은 일차 및/또는 이차 담즙산은 OCA 또는 UDCA와 상승작용하여 PBC와 같은 간 질환의 환자 치료를 개선할 수 있다.
본 발명의 방법 및 조성물은 담즙산 대사를 개선함으로써 이들 질환 및 병태의 하나 이상의 증상을 개선시키는 데 사용될 수 있다. 본 방법은 담즙정체성 질환의 인과관계 병리를 반드시 해결할 필요는 없지만, 총 담즙산 풀을 감소시키고 접합된 일차 담즙산염을 일차 담즙산 및/또는 이차 담즙산으로 전환함으로써 담관 손상의 원인을 고갈시키는 것은 상당한 대안적 접근법이 없는 경우를 포함하여 질환 및 환자 복지의 진행에 중대한 영향을 미칠 수 있다. 이 접근법의 이점은 달리 난치성 질환의 치료, 현재 이용가능한 치료와 비교하여 바람직하지 않은 부작용이 적은 치료, 또는 현재 이용가능한 치료와 연관된 바람직하지 않은 부작용의 감소, 예를 들어, 이용가능한 치료의 유효량을 감소시키는 것을 포함할 수 있다. 달리 나타내지 않는 한, 본 명세서에 사용된 바와 같이 용어 "총 담즙산"은 동물에서 검출된 우세한 담즙산의 합을 의미한다. 인간에서, 이것은 전형적으로 적어도 콜산, 글리코콜산, 데옥시콜산, 타우로콜산, 케노데옥시콜산, 글리코케노데옥시콜산, 타우로케노데옥시콜산, 우르소데옥시콜산, 및 리토콜린산을 지칭한다. 일부 구현예에서, 이것은 또한 a-무리콜산, 베타-무리콜산, 감마-무리콜산(히오콜산), 옥소-담즙산 및 이소-담즙산을 포함한다. 일부 구현예에서, 포유동물 대상체는 담즙정체성 질환 또는 병태의 하나 이상의 증상을 갖는 인간 대상체이다. 일부 구현예에서, 조성물의 효능은 담즙산 조성물, 예를 들어 서로 비교된 선택된 담즙산의 상대 수준 또는 기준과 비교하여 하나 이상의 담즙산의 농도를 측정함으로써 평가될 수 있다. 이러한 조치는 예를 들어 배설물 또는 혈청 담즙산 수준을 사용하여 이루어질 수 있다. 일부 구현예에서, 치료의 대사 징후가 분석될 수 있다. 일부 구현예에서, 조성물로 투여된 박테리아 종의 존재 또는 부재가 분석될 수 있다. 이러한 조치는 또한 환자 요법을 모니터링하기 위해, 예를 들어 환자가 조성물에 의한 추가 치료를 필요로 하는지 여부를 결정하기 위해 사용될 수 있다. 적절한 참조를 확인하는 방법은 당해 기술의 숙련가에게 공지되어 있으며, 예를 들어, 건강한 환자 모집단에서 하나 이상의 담즙산 수준, 질환으로 진단된 미치료 환자 모집단에서 하나 이상의 담즙산 수준, 또는 치료 전 수준과 비교하여 치료 후 환자에서 하나 이상의 담즙산 수준의 개선을 포함한다.
일부 구현예에서, 효과적인 치료는 치료 전 환자의 ALP 활성 또는 농도와 비교하여 예를 들어 간, 혈액 또는 혈청에서 알칼리성 포스파타제(ALP) 활성 또는 농도를 감소시키고; 또는 기준과 비교하여 농도 또는 활성을 감소시킨다. Ocaliva®(오베티콜산)의 FDA 라벨링에 따라, 이러한 감소는 통계적으로 상당한 증상 감소가 관찰되지 않는 경우에도 치료를 정당화하기에 충분하다. ALP 분석 방법은 당해 기술에 공지되어 있다.
일부 구현예에서, 조성물의 효능은 치료 전 빌리루빈 수준과 비교하여 빌리루빈의 감소에 의해 평가될 수 있다. 예를 들어, 일부 구현예에서, 효과적인 치료는 환자의 소변에서 빌리루빈 수준을 데시리터당 25 밀리그램 미만으로 저하시킨다. 빌리루빈은 또한 혈액에서 분석될 수 있으며, 예를 들어 총 빌리루빈은 1.0 mg/dL 미만이다. 빌리루빈 수준을 분석하는 방법은 당 업계에 공지되어 있다.
일부 경우에, 본 발명의 조성물에 의한 효과적인 치료는 하기 중 적어도 하나를 초래한다; 알칼리성 포스파타제 수준을 <1.67 X 정상인 상한치 (ULN)로 감소, 총 빌리루빈을 ≤ULN으로 감소, 또는 알칼리성 포스파타제 감소를 기준선으로부터 15% 이상 감소.
환자에게 투여되는 치료적 조성물의 양 및 빈도는 투여되는 것, 예방 또는 치료와 같은 투여 목적, 환자의 상태, 투여 방식 등에 따라 달라질 것이다. 치료 용도에서, 조성물은 질환의 증상 및 그의 합병증을 치료 또는 적어도 부분적으로 정지시키기에 충분한 양으로 질환을 앓고 있는 환자에게 투여될 수 있다. 효과적인 용량은 질환의 중증도, 환자의 연령, 체중 및 일반적인 상태 등과 같은 요인에 따라 치료되는 질환 상태뿐만 아니라 주치 임상의의 판단에 따라 달라질 것이다. 제형 관련 섹션에서 상기 언급된 투약량 정보를 참조한다.
일부 구현예에서, 상기 대상체는 조성물의 투여 전에 항생제 치료를 받는다. 일부 구현예에서, 상기 대상체는 항생제 치료를 받고, 항생제 치료 이후 및 조성물의 투여 전 적어도 1일, 2일, 3일, 5일, 1주일, 2주일, 3주일 또는 4주일이 경과할 때까지 조성물을 받지 않는다. 일부 구현예에서, 상기 대상체는 투약 기간의 적용범위를 보장하기 위해 다중 용량의 조성물을 수용한다. 일부 구현예에서, 상기 대상체는 조성물의 투여 전에 담즙정체성 질환의 증상을 갖는다. 다른 구현예에서, 상기 대상체는 조성물의 투여 전에 담즙정체성 질환의 증상을 나타내지 않으며, 예를 들어 조성물은 담즙정체성 질환이 임상 증상을 초래할 위험을 감소시키기 위해 예방적으로 투여된다.
일부 구현예에서, 조성물은 질환, 장애 또는 병태의 개선 전에 한 번만 투여된다. 일부 구현예에서, 치료적 조성물은 2일 초과, 예컨대 3, 4, 5 또는 6일마다, 또는 매주 또는 매주보다 덜 빈번하게, 예를 들어, 2주마다, 3주마다, 4주마다, 6주마다, 8주마다, 12주마다, 1개월에 한 번, 2개월에 한 번, 3개월에 한 번, 4개월에 한 번, 또는 6개월에 한 번의 간격으로 투여된다. 일부 경우에, 본 조성물은 정해진 스케줄에 따라 간헐적으로, 예를 들어 하루에 1회, 매주 1회, 또는 매월 1회 또는 상기 대상체가 일차 질환으로부터 재발할 때 간헐적으로 투여된다. 또 다른 구현예에서, 본 조성물은 담즙정체성 질환에 걸릴 위험이 있는 개체에게 장기간에 걸쳐 투여된다.
일부 구현예에서, 본 조성물은 일반적으로 장내 투여된다. 예를 들어, 투여는 삼킨 형태(예를 들어, 알약, 샤세트, 캡슐, 시럽 등)를 통한 경구 투여 또는 구강 또는 비강 튜브(비위, 비뇨관, 구강 위 또는 구강 공장 포함)에 의한 경구 투여일 수 있다. 다른 구현예에서, 투여는 직장 투여(예를 들어, 관장제, 좌제 또는 결장경 검사)를 포함한다. 조성물은 입, 식도, 위, 소장, 대장 또는 직장을 포함하여 위장관의 적어도 하나의 영역에 투여될 수 있다. 조성물은 분말, 하나 이상의 캡슐, 하나 이상의 정제, 겔 또는 액체와 같은 약제 형태로 경구 투여될 수 있다. 조성물은 또한 경구 경로에 의해 또는 경비위관을 통해 또는 겔 또는 액체 형태의 직장 경로에 의해, 결장경을 통한 관장 또는 점적주입에 의해, 또는 좌약에 의해 투여될 수 있다.
상기 대상체는 조성물의 투여 전에 결장-크렌징 제제를 가질 수 있다. 결장경 검사를 위해 대상체를 준비하는 데 사용되는 방법과 같은 결장-크렌징 방법은 당해 기술에 알려져 있다. 또한, 당 업계에 공지되어 있고 대상체에 적합한 것으로 결정된 바와 같이, 대상체는 조성물 투여시 위 pH를 증가시키기 위해 제산제 또는 완충제로 임의로 처리될 수 있다.
조합 요법
상기 논의된 바와 같이, 본 명세서에 기재된 것과 같은 본 발명의 조성물 또는 제형은 담즙정체성 질환의 치료 또는 예방에 유용한 다른 제제와 조합하여 투여될 수 있다. 따라서, 예를 들어, 본 발명의 조성물 또는 제형은 하나 이상의 하기 제제와 조합하여 투여될 수 있다:Ocaliva®(OCA, INT-747), INT-767(FXR/TGR5 효능제), LJN452, GS-9674(PX-102), PX-104, EDP-305, EP 024297, WAY-362450(FXR-450)(XL335), GSK2324, GW4064, 펙사라민, 내인성 담즙산(CDCA, LCA/DCA 및/또는 UDCA). 이들 추가 제형은 본 발명의 조성물 또는 제형과 별개의 조성물로 투여될 수 있거나, 이들과 조합되어 추가의 새로운 조성물을 생성할 수 있다. 추가의 제형은 본 발명의 조성물 또는 제형과 동시에 투여될 수 있거나, 대안적으로는 당해 분야의 숙련가에 의해 적절한 것으로 결정된 바와 같이 본 발명의 조성물 또는 제형의 1, 2, 4, 8, 12, 24, 또는 그 초과 시간 또는 일내에 투여될 수 있다. 본 발명의 조합 또는 제형의 하나의 특정 예에서, Ocaliva(OCA)는 CDCA를 증가시키는 본 발명의 조성물과 조합하여 투여된다.
후보 조성물을 테스트하는 방법
쥣과 모델
담즙산 대사에 악영향을 받은 동물 모델을 사용하여 담즙정체성 질환의 증상을 개선하는 능력에 대한 후보 조성물을 시험할 수 있다. 이러한 모델을 사용하여, 후보 조성물을 모델에 투여하고, 질환의 적어도 하나의 징후 또는 증상의 개선 또는 질환 진행 속도의 감소는 후보 조성물이 담즙정체성 질환 치료에 사용될 수 있음을 나타낸다.
이러한 모델의 한 예는 다중약물 내성 2 녹아웃(mdr2-/-) 마우스이다. mdr2는 간에서 간관으로 포스파티딜콜린(PC)을 내보내는 수송체인, 인간 mdr3의 마우스 동족체이다. PC의 부재는 교질에서 적절하게 격리되지 않은 일차 담즙산염에서 비정상적으로 높은 담즙 조성물을 야기하는 것으로 생각된다. 이 과량의 일차 담즙산염은 이들 동물에서 담즙정체증의 기초가 되는 담관 손상을 유발하는 것으로 생각된다. (Smit 등, Cell 75:451-462, 1993; Fickert 등, Gastroenterology 127:261-274, 2004). mdr2-/- 넉아웃 마우스는 원발성 경화 담관염(PSC)으로 진단된 인간에서 볼 수 있는 것과 유사한 특징을 갖는 담관 손상 및 특히 담도 협착 및 간 섬유증과 관련하여 담즙산의 비정상과 연관된 다른 장애를 발생시킨다. 이들 마우스에는 담도 인지질이 결여되어, 담즙산이 과다한 교질입자로 인해 담관 염증과 손상을 유발하며, 원발성 경화성 담관염을 모방하는 병리생리학으로 발전한다.
LaRusso와 동료들은 mdr2-/- 유전자 배경을 갖고 무균(GF)이 상승된 마우스가 종래에 하우징된 (CH) mdr2-/- 마우스보다 더 심각한 형태의 질환을 발병한다는 관찰에 근거하여 mdr2-/- 모델의 추가 발달을 보고했다(Tabibian 등, Hepatology 2015). 이 모델에서, GF가 상승된 mdr2-/- 마우스는 GF 상태와 연관된 창자 조직에서의 전형적인 변경, 예컨대 더 얕은 결장 선와, 줄어든 회장 융모 길이, 및 상피성 융합막 단백질의 감소된 발현, 폐쇄 소대(zonula occludens)를 나타낸다. 그러나, 통상적으로 제기된 mdr2-/- 마우스와 비교하여, 아스파르테이트 아미노기 전달효소, 알칼리성 포스파타제 및 빌리루빈의 증가를 포함하여 60일령의 간담도 질환에 대한 혈청 생화학적 마커에서 차이가 관측된다. 담관세포 노화는 간 조직에서 p16INK4a 원위치 하이브리드화에 의해 평가되었고, 무균 마우스에서 상당히 증가되었다. 이들 생화학적 및 조직화학적 마커는 조직병리 측정에 의해 추가로 확인되었다. 또한, 담즙산 조성물의 분석은 무균 마우스에 대해 예상되는 바와 같이 미생물 활성으로부터 유래된 일차 또는 이차 담즙산의 부재를 보여주었다. 알칼리성 포스파타제, 아스파르테이트 아미노기전달효소 및 빌리루빈을 포함한 혈청 생화학은 GF mdr2-/- 마우스에서 모두 상당히 더 높았다. 더 어린 GF mdr2-/- 마우스(30일령)는 또한 통상적으로 제기된 mdr2-/- 코호트보다 더 심각한 간담도 질환을 나타내는 변경된 혈청 생화학적 마커를 나타낸다.
2007년에 Fickert 등(하기 참조)이 개발한 담즙정체성 질환의 두 번째 모델(Fickert 등, Am. J. Pathol.171(2):525-536, 2007)은 담관염 및 간 섬유증을 유발하는 화합물 3,5-디에톡시 카보닐-1,4- 디하이드로콜리딘(DDC)을 사용하여 담관 손상 및 폐색을 유도한다. 종래의 스위스 알비노 마우스에서, DDC 치료는 염증, 섬유증, 담관 폐색 및 만성 담관염을 초래하였으며, PSC 환자에서 볼 수 있는 것과 같은 알칼리성 포스파타제 및 알라닌 전달효소 수준 상승과 같은 증상을 동반하였다. 4주 이내에 증상이 보임에 따라 담즙정체성 질환을 신속하게 연구할 수 있다. 그러나, 이 화학 모델에서의 미생물군집의 역할은 탐구되지 않았으며, DDC-식이 유도 간 질환에 대한 무균 마우스의 감수성에 미치는 미생물 담즙산 대사의 효과는 본 특허에서 설명된다.
보고된 바와 같이, 담즙산 프로파일은 일차 담즙산과 관련하여 (HPLC에 의해) GF와 CH mdr2-/- 마우스간에 유의차를 나타내지 않는다. 그러나, 총 혈청 담즙산 수준은 mdr2-/- 마우스에서 상당히 더 높았다. 유사하게, 담즙정체증의 DDC-식이 모델에서 총 혈청 담즙산이 상승되었지만, 담도 담즙산의 수준은 질환에 의해 변경되지 않았다. 무균 마우스는 미생물 활성의 부족으로 인해 이차 담즙산을 만들 수 없다. 따라서, 무균 모델은 일차 담즙산의 탈접합 또는 일차 담즙산에서 이차 담즙산으로의 전환과 같은 특정 담즙산 효소적 활성을 강조하도록 설계된 다양한 박테리아 조합의 평가를 가능하게 한다. 또한, 이 스크린은 또한 특정 일차 또는 이차 담즙산 또는 담즙산의 조합을 평가하여 생체 내에서 질환 표현형의 변화를 매개할 수 있는 것들을 확인할 수 있게 한다. 일부 구현예에서, 본 모델 또는 본 명세서에 기재된 다른 모델에서 시험된 박테리아 조성물은 일차 및 이차 담즙산의 총 수준을 변경시켜, 질환 표현형에 대한 담즙산 조성물 변경의 효과를 측정할 수 있게 한다.
쥣과 PSC/담즙산 질환 모델에서 조성물의 효능을 평가하는 추가의 방법은 Tabibian 등에 의해 기술된 방법을 사용하여 무균 한배새끼와 비교하여 정의된 미생물 조성물로 통상적인(conventionalization) 마우스의 조직학적 평가를 포함한다. (Hepatol.63:185-196, 2015). 무균 mdr2-/-는 CH mdr2-/- 마우스와 비교하여 진행된 간 섬유증의 비율이 상당히 높으며, 일부 경우에 60일까지 간경변을 보이는 반면, CH mdr2-/- 마우스는 간경변이 발생하는 것으로 보고되지 않았다. 따라서, 본 명세서에 기재된 조성물로 치료된 GF mdr2-/- 마우스에서 간 섬유증의 감소는 본 조성물이 NAFLD 또는 NASH와 같은 담즙산 신호전달과 관련된 PSC 또는 다른 장애를 치료하는데 유용하다는 것을 나타낸다. GF mdr2-/- 마우스를 사용하여 후보 조성물의 효과를 평가하는 다른 방법은 PSC 또는 담즙산 대사의 다른 장애 치료에 유용한 조성물의 존재 하에서 연성 반응 및 연성감소증의 감소 및 노화성 담관세포의 비율의 감소 및 간 효소, 예를 들어 ALP 및 혈청의 빌리루빈 감소를 검출하는 것을 포함한다.
후보 조성물은 상기 기재된 바와 같이 mdr2-/- GF 모델 또는 DDC-식이 유도된 담즙정체성 질환 모델의 무균 버전에서 시험될 수 있다. 예를 들어, 실시예(하기)에 기재된 바와 같은 담즙산 대사의 적절한 장애의 임의의 다른 적합한 모델이 또한 사용될 수 있다. 이러한 장애, 즉 치료적 조성물을 치료하는데 유용한 후보 조성물은, 적합한시간 동안 투여될 때, 후보 조성물을 받지 않은 동물과 비교하여 장애의 동물 모델에서 질환의 적어도 하나의 징후 또는 증상을 감소시키는 조성물이다.
질환의 징후 및 증상을 확인하는 방법 및 이의 개선은 당해 기술에 공지되어 있다. 예를 들어, 혈청 중 담즙산 농도는 비색계 방법을 사용하여 분석될 수 있다(예를 들어, Trinity Biotech(Jamestown, NY)의 키트). 탠덤 질량 분광분석법(GC-MS 또는 LC-MS/MS)와 조합된 박막 크로마토그래피, 고-성능 액체 크로마토그래피(HPLC), 기체 크로마토그래피, 또는 액체 크로마토그래피를 사용하여 담즙산 대사 효소 활성 및 담즙산의 조성 변화를 검출할 수도 있다.
질환의 동물 모델에서 선택된 담즙산 장애와 연관된 적어도 하나의 징후 증상을 예방 또는 개선하는 조성물은 "치료적 조성물"로 지칭되며, 장애를 치료하는데 유용하다.
등가물
모든 기술 특징은 이러한 특징의 가능한 모든 조합으로 개별적으로 조합될 수 있다.
본 발명은 그의 사상 또는 본질적인 특성을 벗어나지 않으면서 다른 특정 형태로 구현될 수 있다. 그러므로 전술한 구현예는 모든 면에서 본 명세서에 기재된 본 발명을 제한하기보다는 예시적인 것으로 간주되어야 한다.
실시예
하기 비-제한적인 예는 본 명세서에 기재된 본 발명의 구현예를 추가로 설명한다.
실시예 1: 물질 및 방법
물질
타우로콜산(t-CA), 타우로케노데옥시콜산(t-CDCA), 글리코콜산(gCA), 글리코케노데옥시콜산(gCDCA), 콜산(CA), 케노데옥시콜산(CDCA), 데옥시콜산(DCA), 리토콜린산(LCA), 및 3,5-디에톡시카보닐-1,4-디하이드로콜리딘(DDC)을 Sigma-Aldrich (St. Louis, MO)로부터 입수하였다. 베타-무리콜산(bMCA), 7-옥소콜산, 7-옥소케노데옥시콜산 및 타우로-베타-무리콜산(t-MCA)은 Santa Cruz Biotechnology(Dallas, TX)로부터 입수하였다. 알파-무리콜산(aMCA), 타우로-알파-무리콜산(t-MCA), 12-옥소콜산, 12-옥소데옥시콜산, 3-이소데옥시콜산(3β 12α), 히오데옥시콜산(3α 6α), 히오콜산(HCA) 및 3-옥소데옥시콜산은 Steraloids(Newport, RI)로부터 입수하였다. LC-MS 기반 효소적 검정에 사용된 담즙산 스톡은 에탄올에 화합물을 용해시켜 제조하였다. 세포-기반 검정에 사용된 케노데옥시콜산(CDCA; Sigma-Aldrich) 및 오베티콜산(OCA; MedChemExpress, NJ)을 DMSO에 용해시켜 스톡을 제조하였다.
군집화
무균 및 종래의 마우스는 Taconic Biosciences(Hudson, NY)로부터 구입하여, 포괄적으로 6~10주령 사이에 사용하였다. 무균 마우스에 경구 위관영양법을 통해 100 μL 7.5% 중탄산나트륨을 투약하여 위장관 산을 중화시키고 투여된 박테리아의 생존성을 개선시켰다. 중탄산나트륨을 투여받은 약 10~30분 후, 마우스에 경구 위관영양법을 통해 200 ㎕의 특정 박테리아 조성물을 투약하였다. 마우스를 무균 방식으로 처리하고, 무균 격리기에 수용하고, 멸균 차우(chow) 및 물을 제공하였다. 모든 연구는 각각의 연구 부위에 대해 개별 동물 관리 및 사용위원회의 승인을 받았다.
배설물 수집
투약 직전에, 신선한 배설물 펠릿을 마우스로부터 직접 수집한 후, 투약 후 1일, 3일, 7일 또는 매주 수집하였다. 각각의 시점에서, 2개의 배설물 펠릿을 멸균 1.7mL 마이크로원심분리기 튜브에 수집하였다. LC-MS에 의한 분석을 위해 하나의 배설물 펠릿을 -80℃에서 냉동시켰다. 두 번째 배설물 펠릿을 PBS(v/v)에서 100 μL의 15% 글리세롤로 균질화한 다음, -80°C에서 냉동시켜 미생물 및 서열 분석을 유지하였다.
서열 분석
차세대 서열분석 (NGS; 고처리량 서열분석)을 사용하여 16S rDNA V4 서열을 사용하여 서열을 분석하고, 가장 근접한 해당 OTU를 확인하도록 맵핑하였다. 모든 종 호출에 대해 서열 동일성은 적어도 97%(최근접한 0.1%)였다. 종 동일성을 할당하기 위해 내부 독점 수동 큐레이션된 기준 OTU 데이터베이스를 사용하였다.
담즙산염 가수분해효소(BSH) 활성 분석
PBS 중의 박테리아 전체 세포 현탁액을 각각 150 ㎍/ml의 최종 농도로 접합된 담즙산의 혼합물과 함께 인큐베이션하였다. 96-웰 플레이트의 반응 혼합물을 혐기성 조건 하에서 37℃에서 4시간 동안 인큐베이션하였다. 인큐베이션 후, 샘플을 혐기성 챔버로부터 제거하였다. 동등 용적의 아세토니트릴을 샘플에 첨가하여 담즙산을 추출하고, 플레이트를 펠릿 박테리아로 원심분리하고, 생성된 상청액을 0.2 μm 필터를 통해 여과하여 LC-MS 분석을 위한 샘플을 생성하였다.
하이드록시스테로이드 탈수소효소 및 7α-디하이드록시화 활성에 대한 분석
하이드록시스테로이드 탈수소 효소(HSDH) 및 7α-디하이드록실화 활성을 분석하기 위해, 뇌 심장 주입(BHI) 배지의 박테리아 현탁액을 각각 혐기성 챔버에서 37℃에서 4시간 동안 각각 100 μM의 농도로 콜산 또는 케노데옥시콜산과 개별적으로 인큐베이션하였다. 인큐베이션 후, 샘플을 혐기성 챔버로부터 제거하였다. 동등 용적의 아세토니트릴을 샘플에 첨가하여 담즙산을 추출하고, 플레이트를 펠릿 박테리아로 원심분리하고, 생성된 상청액을 0.2 μm 필터를 통해 여과하여 LC-MS 분석을 위한 샘플을 생성하였다.
설계된 조성물
연구 세포 은행(RCB)의 수집을 사용하여 생체내 연구를 위한 설계된 조성물(DE)을 생성하였다. 각 세포 은행의 영양 역가(CFU/mL)를 사용하여 각각의 용량에 대해 최종 역가 1.00E+07 CFU/균주를 갖는 설계된 조성물을 생성하는데 필요한 각각의 용적을 계산하였다. 설계된 조성물에 첨가될 개별 RCB의 용적은 아래와 같이 계산하였다:
[모든 용량에 필요한 총 영양 역가(예를 들어, 1.00E+07 = 1.00E+08 CFU 총 10 용량)]/[RCB 영양 역가(CFU/mL)] = 1.00E+07 CFU에 필요한 용적/10 용량에 필요한 용량
이를 정의된 DE의 각 RCB에 대해 반복하여 용적을 결정한 후, 각각의 RCB의 계산된 용적을 혐기성 챔버에서 조합하여 RCB를 형성하고, 와동시키고, 스펀 다운시키고, 최종 용적 15% 글리세롤-PBS로 재현탁시켰다.
마우스 배설물 및 간 샘플에서의 담즙산 추출
마우스 배설물 펠릿을 칭량하고, 10x w/v 추출 완충액(물 중 50% 메탄올)에서 균질화하고, 얼음에서 1시간 동안 추출하였다. 간 조직 샘플을 유사하게 칭량하고, 2x w/v 추출 완충액(물 중 50% 메탄올)에서 균질화하고, 얼음에서 1시간 동안 추출하였다. 인큐베이션 후, 동등 용적의 차가운 아세토니트릴로 샘플을 추가로 추출하고, 원심분리하고, 분석을 위해 LC-MS에 로딩하기 전에 0.22 ㎛ 필터를 통해 상청액을 여과하였다.
관문, 혈청 및 담즙 샘플에서 담즙산 추출
주변 혈청 샘플을 아세토니트릴에서 1:1로 희석하고, 원심분리하고, 분석을 위해 LC-MS에 로딩하기 전에 0.22 μm 필터를 통해 상청액을 여과하였다. 관문 혈청 샘플을 아세토니트릴에서 1:10으로 희석하고, LC-MS 분석 전에 유사하게 원심분리하고 여과하였다. 마지막으로, 담즙 샘플을 아세토니트릴에 1:100으로 희석하고, 원심분리한 후, LC-MS 분석을 위해 0.22 μm 필터를 통해 여과하였다. 인간 및 마우스 샘플 모두에 동일한 절차가 이용되었다.
담즙산의 LC-MS 분석
0.2 μm 프리-컬럼 필터가 선행된 Microsolv 두자리 C18 컬럼이 장착된 Agilent 1260 HPLC를 사용하여 담즙산을 분리하였다. 0.4 ml/분의 유량으로 0.1% 포름산을 갖는 물 및 아세토니트릴 구배를 사용하여 분리를 달성하였다. 5 μL의 용적으로 샘플을 주입했다. HPLC 시스템을 애질런트(Agilent) 저-질량 튜닝 믹스를 사용하여 50 내지 1700 m/z의 질량 범위로 보정된 Bruker Compass™ qTOF 질량 분광분석기에 연결했다. 각 시행은 각 시행의 시작 부분에 주입된 참조 질량 용액으로 추가로 교정되었다. 담즙산을 음성 모드로 검출하고, Bruker 데이터 분석 소프트웨어를 사용하여 결정된 피크 하의 공지된 순수한 표준 및 면적과 비교하여 고유한 m/z 및 체류 시간으로 확인하였다. PBS에서 0.001 μM ~ 100 μM의 농도 범위에서 순수한 표준으로 생성된 보정 곡선을 사용하여 대사물을 정량화했다. 배설물 샘플의 경우, 개별 담즙산은 총 담즙산 풀의 퍼센트로 표시되며, 여기서 총 담즙산 풀은 샘플에서 검출된 모든 담즙산의 합으로 결정된다. 간 샘플의 경우, 총 담즙산 수준을 검출된 모든 담즙산의 합으로 결정하고, 샘플 조직 중량(nM/ng )으로 정규화하였다. LC-MS에 의해 검출된 담즙산은 하기와 같이 표 4에 열거되어 있다.
유전자 발현 프로파일링
투여 후 3일에 마우스로부터 얻은 원위 회장 샘플을 수집시 급속 냉동시켰다. RNA를 균질화에 의해 단리하고, 이어서 제조사의 지침에 따라 Qiagen RNeasy® Plus Mini 키트를 사용하여 추출하였다. 실시간 qPCR 반응은 ~ 50 ng RNA를 사용한 RNA-to-CT 원스텝 qPCR 발현 키트(Life Technologies, Carlsbad, CA)에 의해, 및 베타-액틴에 대한 Taqman® 프라이머, NR1H4(Mm00436425_m1), NRB02(Mm00442278_m1), 또는 FGF15(Mm00433278_m1)에 의해 실행하였다. 모든 유전자 발현은 하우스키핑 유전자인 베타-액틴의 발현으로 정규화되었다.
hFXR 루시퍼라제 리포터 분석
FXR 리포터 세포 분석은 Indigo의 FXR 리포터 CHO 세포주를 사용한 Seres Therapeutics의 지침에 따라 Indigo Biosciences에 의해 수행되었으며, 이는 네이티브 N-말단 DNA 결합 도메인(DBD)이 효모 Gal4 DBD의 것으로 대체된 FXR 수용체 하이브리드를 발현한다. 개똥벌레 루시퍼라제인, 리포터 유전자는 Gal4 업스트림 활성화 서열(UAS)에 기능적으로 연결되어 있다. 간단히, 리포터 세포를 CDCA, OCA 또는 비히클(0.2% DMSO)의 연속 희석 곡선에 제출하고, 고-습도, 5% CO2 챔버에서 24시간 동안 37°C에서 인큐베이션하였다. 기질 및 검출 시약과의 인큐베이션 후 발광을 결정하였다. 또한, 생존 세포 수는 생존 세포 다중화(LCM) 검정(Indigo Biosciences)을 사용하여 분석 내에서 결정하였다. 데이터는 비히클 그룹에 정규화된 것으로 표시된다(도 7).
혈청 알칼리성 포스파타제 수준(ALP) 분석
전혈 또는 혈청 샘플을 ALP 측정에 사용하였다. 100 μL의 샘플을 VetScan 포유동물 간 프로파일 디스크(Abaxis)에 장입하고, VetScan VS2 시리즈 화학 분석(Abaxis)을 사용하여 분석하였다. 추가적인 혈청 생화학적 분석 보고서뿐만 아니라 ALP 수준이 비교를 위해 인쇄되었다.
이 실시예에 기재된 방법은 특정 담즙산 대사 특징을 갖는 박테리아를 확인하는데 유용하다. 다른 상기 방법은 당해 기술의 숙련가에게 알려져 있다.
실시예 2: 설계된 조성물은 시험관내에서 특정 담즙산 활성을 입증한다.
무균 마우스 모델에서, 출원인은 총 담즙산 수준의 표적화된 감소 및 구체적으로, 설계된 박테리아 조성물을 사용하여 일차 담즙산을 그의 이차 대응물로 전환시키는 것을 입증하였다. 출원인은 또한 설계된 조성물에 의한 이차 담즙산 경로의 표적화된 회복에 의해 영향을 받는, 장자내 담즙산 특이적 신호전달을 입증하였다. 이러한 실험은 아래에서 더욱 상세하게 기재된다.
특정 대사 활성을 갖는 박테리아 균주의 조합을 생성하기 위해, 시험관내 개별 박테리아 균주의 담즙산 대사 활성을 특성화하기 위한 방법을 설계하였다. 따라서, LC-MS 기반 스크리닝 접근법을 사용하였다. 거의 200개 균주를 스크리닝하여 다수의 인간 박테리아 단리물에서 탈접합, 산화 및 7-알파 디하이드록실화(7α-deOH)를 포함하는 다양한 담즙산 대사 활성을 확인하였으며; 예가 도 1a에 도시되어 있다 (또한, 표 3 참조). 담즙산 탈접합은 담즙산염 가수분해효소(BSH)에 의해 촉매접촉된다. 상이한 BSH는 상이한 접합된 일차 담즙산염에 대한 활성을 선호할 수 있다. 일부 경우에, 박테리아는 둘 이상의 BSH를 가지며, 이들 중 적어도 2개는 서로 기질-특이적 활성이 상이하다. 예를 들어, 출원인은 BSH 서열에 대한 인간 미생물군집 프로젝트 데이터베이스에 제시된 1129개의 게놈을 질의하였고, 이들 게놈의 43%가 BSH 서열에 상응하는 서열을 갖고 게놈은 1 내지 6개의 이러한 서열을 가짐을 발견하였다. 따라서, 일부 경우에, DE에 대한 종을 선택하는 기준은 둘 이상의 BSH의 존재, 예를 들어 다중 유형의 접합된 일차 담즙산염을 대사작용하는 능력이다. 다른 사례에서, 종은 특이성, 예를 들어 단 하나의 특정 접합된 담즙산염을 절단하는 능력을 위해 선택된다. 산화 반응은 하이드록시스테로이드 탈수소효소(HSDH)에 의해 촉매접촉되는 반면, 7α-디하이드록시화는 바이오페론에 의해 촉진되는 다단계 공정이다. 놀랍게도, 속 내의 다중 균주가 시험된 경우에, 시험된 3가지 반응 중 어느 하나에 대한 기질 특이성 또는 효소 활성의 명백한 패턴은 없었다. 또한, 활성 수준의 특이성에 있어서의 변화는 상이한 공여체로부터 동일한 종의 다수의 단리물 사이에서도 나타났다.
이전에 언급한 바와 같이, 분기군 내의 종의 가능성은 유사한 기능을 가지므로 특정 기능을 갖는 조성물을 생성하는데 유용한 종의 풀을 제공한다. 그러나, 종과 OTU 및 균주 사이의 활성 변화(표 3)는 시험관내 분석 또는 게놈 분석에 의해 목적하는 담즙산 대사 능력을 갖는 조성물의 구축에 필요한 관심 균주에서의 활성을 확인한다.
담즙산 대사 활성이 측정된 박테리아 균주를 특정 담즙산 대사 특징을 갖도록 설계된 조합으로 시험하였다. 특정 담즙산 대사 활성을 갖는 3가지 조성물을 설계하고 제조하였다(도 1b). 대조군의 "BA 활성 없음" 조성물은 단일 균주로서 상기 기재된 바와 같이 시험할 경우 담즙산 대사 활성을 나타내지 않은 균주로 구성되었다. 또한, 상기 기재된 분석에서 사용될 때, 혼합 조성물은 임의의 검출가능한 담즙산 대사 활성을 나타내지 않았으며, 이는 이들 균주가 서로 조합되어 담즙산 대사 활성과 관련하여 상보적인 특징이 없음을 시사한다. 두 번째 조성물인 'BSH 단독 활성 조성물'은 담즙산 대사 활성만 검출된 균주가 BSH 활성인 균주로 이루어졌으며, 이로 인해 일차 담즙산염의 탈접합으로 제한되고 탈접합된 일차 담즙산을 그것의 이차 유도체로 추가로 변형시킬 수 없었던 조성물이 생성되었다. 시험된 접합된 담즙산염에는 글리신 및 타우린 접합된 콜산 및 케노데옥시콜산뿐만 아니라 타우린 접합된 α-무리콜산 및 β-무리콜 산이 포함된다. 최종 조성물인 "최대 담즙산"(Max BA 활성) 조성물은 상기 기재된 2개의 이차 담즙산 효소적 활성, 산화 및 7α-디하이드록실화뿐만 아니라 BSH 매개 탈접합 활성을 포함하도록 설계되었다. 조합의 활성은 시험관내 분석에서 확인되었다(도 1b).
이들 데이터는 시험관내 방법이 담즙산 대사를 변경시키는 데 효과적인 조성물을 구축하는데 사용될 수 있음을 입증한다.
군집화된 무균 마우스는 조성물로부터의 종와 빠르게 접목
박테리아 GI 군집화의 무균 마우스 모델을 사용하여 생체내에서 특정 박테리아 조성물의 담즙산 대사 활성을 특성화하였다. 무균 마우스에는 임의의 미생물이 없다. 따라서, 마우스가 무균 환경에서 유지되는 한, 특정 박테리아 조성물을 무균 마우스에 도입하면 조성물의 담즙산 대사 활성을 직접 분석할 수 있다.
5개의 무균 마우스를 상기 기재된 시험관내 실험에 사용된 3개의 박테리아 균주로 구성된 "담즙산 활성 없음" 조성물로 군집화시켰다. 조성물로 투약하기 전 및 투약 후 6시간, 1일, 3일 및 7일에 배설물 샘플을 수집하고, 군집화 미생물을 검출하기 위해 NGS로 분석하였다. 아래의 군집화 데이터는 박테리아 분기군 수준에서 보고된다. 16S v4 NGS 서열분석으로 추론된 종 확인을 통해 박테리아 분기군을 정확하게 확인할 수 있다. 이것은 '담즙산 없음' 조서울에서 3종이 뚜렷한 분기군에 속하기 때문에 가능했으며; 이 경우, 분기군 수준에서의 분석은 군집화후 마우스에 존재하는 균주에 관한 정확한 데이터를 제공한다.
NGS를 사용하여 관측된 박테리아 수의 결여에 기초하여 실험을 시작할 때 5마리의 마우스 모두에 무균이 없는 것으로 확인되었다(도 2 참조). 마우스 전-처리의 배설물로부터 박테리아가 배양되지 않아, 무균 상태를 추가로 확인하였다. 24시간까지, 처리된 마우스의 미생물군집은 조성물 박테리아가 속하는 분기군으로부터의 서열만을 가졌다. 이후의 시점(3일 및 7일)은 또한 "담즙산 없음" 조성물 내의 박테리아가 속하는 3개의 분기군만을 함유하는 것으로 밝혀졌다. 이는 조성물 중 박테리아 만이 무균 마우스의 위장관을 안정적으로 군집화했음을 나타낸다. 이들 데이터는 무균 모델을 사용하여 조성물을 분석하기 위한 군집화 실험을 테스트할 수 있음을 입증한다.
군집화된 무균 마우스는 특정 배설물 담즙산 프로파일을 보여준다
담즙산 대사와 관련된 조성물을 시험하기 위한 쥣과 군집화 모델의 적합성 및 표적화된 방식으로 담즙산 대사를 변화시키는 박테리아 조성물의 능력을 추가로 조사하기 위해, 설계된 조성물로 군집화된 무균 마우스로부터의 배설물 샘플을 무균 및 통상적인 대조군 마우스와 비교하여 담즙 산 조성물에 대해 분석하였다.
무균 마우스의 배설물에서 접합된 일차 담즙산염만 검출되었다. 접합된 일차 담즙산염은 간에 의해 합성되며, 배설물에서의 유병률은 GI 박테리아에 의해 촉매접촉되어 (비접합된) 일차 및 이차 담즙산을 생성하는 담즙산 대사의 부족을 입증한다. 유사하게, 담즙산 활성이 없는 조성물로 군집화된 마우스는 처리되지 않은 무균 마우스와 동일한 담즙산 프로파일과 함께, 배설물 샘플에서 검출가능한 일차 담즙산 및 이차 담즙산의 완전한 결핍을 실증하였다(도 3). 대조적으로, 특정 무-병원체 마우스(SPF 마우스)로부터의 배설물 제제로 무균 마우스를 군집화시킨, 통상적인 마우스, 도 3의 "통상적인" 마우스, 본원에서 배설물 미생물군집 이식(FMT)으로 지칭되는 과정은 다양한 일차 및 이차 담즙산을 포함하여 처리되지 않은 야생형 마우스에서 볼 수 있는 것과 유사한 다양한 배설물 담즙산 프로파일(도 3)을 나타냈다.
미생물군집-매개된 담즙산 대사의 제1 단계는 접합된 일차 담즙산염으로부터 타우린 또는 글리신 잔기의 BSH에 의한 제거인 접합된 탈접합(deconjugation)이다 (Ridlon 등, JLR 47: 247-259, 2006). 박테리아 조성물에 의한 무균 마우스의 군집화는 BSH 활성만으로 제한되어, 이전에 검출된 접합된 일차 담즙산염 이외에도 탈접합된 일차 담즙산(일차 담즙산)을 함유하지만 다운스트림 이차 담즙산은 함유하지 않은 마우스 배설물 샘플을 수득하였다(도 3). 하나의 경우에, 단일 마우스는 낮은 수준의 마우스 무리콜산 유도체, 이소-담즙산 (3α, 6α 무리콜 산)을 가졌다. 단일 마우스에서 검출된 이러한 특이점 담즙산은 종래의 야생형 마우스에서 전형적으로 보여지는 것보다 10배 낮은 수준이었고, 간에서 불완전한 무리콜산 합성의 부산물일 수 있다.
본 실시예의 데이터는 접합된 일차 담즙산염이 BSH 활성을 갖는 박테리아 조성물의 도입에 의해 생체내에서 탈접합될 수 있음을 입증한다. 게다가, 이는 생체내 활성이 조성물의 시험관내 활성에 상응할 수 있음을 입증한다(도 1b).
접합된 일차 담즙산염의 탈접합 후, 생성된 일차 담즙산은 간에서 담즙산 대사의 신호전달 및 조절에 영향을 줄 수 있는 다양한 이차 담즙산으로 GI 미생물군집에 의해 추가로 변형된다. 7일 동안 Max BA 활성 조성물에 의한 무균 마우스의 군집화는 마우스 SPF/FMT 마우스 배설물 샘플에 의해 군집화된 통상적인 마우스에서 보이는 것과 유사한 수준으로 많은 탈접합된 일차 및 이차 담즙산을 생성하였다(도 3). Max BA 군집화된 마우스에서 회복된 이차 담즙산은 7α-디하이드록실화된 담즙산(DCA 및 LCA) 및 옥소-담즙산(7-옥소 CA, 3-옥소 CDCA, 12-옥소 DCA, 3-옥소 LCA) 및 이소-담즙산(UDCA)을 포함하였으며, 미생물 담즙산 대사의 상당 부분이 설계된 박테리아 조성물로 회복될 수 있음을 입증한다. 관찰된 유일한 예외는 이소-담즙산 3b, 12a-DCA였으며, 이는 Max BA 활성 군집화된 마우스에서 검출되지 않았다. 임의의 특정 이론에 전념하지 않으면서, 3b,12a-DCA의 형성은 DCA에 특이적인 담즙산 이성질체화 활성을 필요로 하며, 이는 7b-HSDH 효소에 의해 촉매접촉되며, 이는 이 실험을 위한 박테리아 조성물에서 선택되지 않는다. 이 활성은 Max BA 활성 구성에 존재하지 않았을 가능성이 있다.
tCDCA는 통상적인 마우스에서 검출되었고, max-BA 마우스에서는 검출되지 않았다(도 3). 이는 Max BA 조성물이 모든 tCDCA를 DCA 및 옥소-담즙산으로 완전히 전환시키는 반면, 통상적인 마우스는 통상적인 마우스의 미생물총 조성물보다 접합된 담즙산의 전환에서 더욱 효율적이지 않았음을 나타낸다. 이는 DE가 생체내에서 담즙산 풀을 선택적으로 형성할 수 있고, 이 특징이 담즙산 대사 또는 신호전달의 결함과 연관된 질환을 가진 환자에게 유용할 수 있음을 추가로 입증한다.
또한, 도 3에 도시된 바와 같이, Max BA 조성물은 HCA 활성의 존재를 나타내지 만, 통상적인 마우스에서는 아무것도 검출되지 않았다. 이 경우, HCA는 통상적인 조성물만큼 완전히 Max BA 조성물에 의해 대사작용되지 않을 가능성이 있다. 이들 데이터는 담즙산 연관된 질환을 개선하기 위해 풀을 선택적으로 정규화 또는 달리 조정하기 위해, 환자의 담즙산 풀의 조성을 변경하기 위해 선택된 담즙산 활성을 갖는 설계된 조성물의 유용성을 추가로 입증한다.
위장관에서 박테리아 담즙산 대사를 회복하면 총 간 담즙산 풀이 낮아졌다.
본 발명의 일부 양태에서, 담즙정체성 질환 환자는 담즙산 풀의 감소로부터 유익할 수 있다. 일차 및 이차 담즙산은 간에서 담즙산 합성을 조절하기 위해 FXR을 통해 신호를 보내 CYP7A1 및 기타 담즙산 합성 유전자의 발현을 조절하여 존재할 때 담즙산 생성을 감소시킨다(Hylemon 등, JLF 50:1509-1520, 2009). 일차 및 이차 담즙산 풀이 없는 무균 마우스는 종래의 마우스에 비해 담즙산 생산이 증가하고 총 담즙산 수준이 더 높은 것으로 보고되었다(Sayin 등, Cell Metab.17:225-2235, 2013). 담즙산 합성에 대한 설계된 박테리아 조성물의 효과를 결정하기 위해, 무균 마우스, 설계된 조성물로 군집화된 마우스 및 종래의 마우스의 총 간 담즙산 풀을 상기 기재된 방법을 사용하여 분석하였다.
이러한 연구에서, 무균 마우스는 FMT/통상적인 마우스 및 야생형 마우스에 비해 상승된 담즙산 풀을 가졌다(도 4). BA 활성이 없는 조성물에 의한 군집화는 총 담즙산 풀에 영향을 미치지 않았으며, 이는 처리되지 않은 무균 마우스와 비교하여 상승된 상태로 유지되었다. BSH 단독 또는 Max BA 조성물에 의한 군집화는 총 간 담즙산 풀에서 야생형 마우스와 비교할 수 있는 수준으로 상당한 감소를 초래하였으며(도 4), 즉 일차 및 이차 담즙산 모두에 의해 담즙산 수용체를 통한 신호전달이 있고, 이에 의해 간에서 담즙산 풀에 영향을 미친다.
FGF15는 특정 담즙산 활성을 갖는 박테리아 조성물에 반응하여 차별적으로 조절된다
담즙산, 특히 비접합된 일차 담즙산 CDCA는 파르네소이드 X 수용체, FXR(NR1H4)을 통해 회장에서 신호전달되어, FGF15의 상향조절을 야기하는 것으로 보고되었다. FGF15는 간에서 작용하여 담즙산 합성을 감소시키고, 따라서 장간 시스템에서 총 담즙산을 감소시킨다. 따라서, FGF15 유전자 발현은 설계된 박테리아 조성물에 의해 유도된 담즙산 프로파일의 변화가 기능, 특히 FXR 신호전달을 변화시킬 수 있는지를 테스트하기 위한 바이오마커로서 사용되었다. 문헌에 보고된 바와 같이, FXR 수준 자체는 변하지 않을 것으로 예상되었다(Sayin 등, Cell Metab.17:225-235, 2013; Song 등, Tox.Appl.Pharmacol.283:57-64, 2015).
이들 실험에서, 무균 유래 동물은 쥣과-유래된 배설물 미생물군집 이식(FMT)으로 군집화되어 무균 동물과 비교하여 FGF15 유전자 발현(200x - 300x)을 상당히 상향조절하였다(도 5b). 이들 통상적인 마우스의 FGF15 수준은 야생형 통상적인 마우스에서 관찰된 것과 유사하였다. 이들 데이터는 FXR 신호전달을 조절하는데 있어서 복잡한 GI 미생물군집의 역할을 확인한다. 최대 담즙산 활성을 함유하는 한정된 박테리아 조성물로 군집화된 마우스는 무균 마우스와 비교하여 FGF15 수준이 증가하였다. 이들 데이터는 이차 담즙산의 존재하에 FXR 신호전달의 회복을 입증한다(도 5b). 놀랍게도, 담즙산 활성이 없는 조성물이 제공된 동물은 FGF15 수준의 작은 증가(약 8배)를 보였으며, 이는 일부 FGF15 활성이 이차 담즙산 대사와 무관하게 미생물군집의 존재에 의해 유도될 수 있음을 나타낸다(도 5). 그러나, 담즙산 조성물로 군집화된 마우스에서 FGF15의 수준은 통상적인 또는 최대 담즙산 활성 군집화된 마우스에서 관찰된 수준보다 상당히 낮았다. 그에 반해서, 마우스는 일차 담즙산을 생성하지만 이차 담즙산은 생성하지 않았고 FXR을 활성화시킬 것으로 예상된 BSH 단독 활성 조성물로 군집화된 마우스는 FGF15 발현에서 변화를 나타내지 않았다(도 5b).
일차 담즙산 CDCA에 의한 공동 처리는 시험관 내에서 OCA의 활성을 향상시킨다
오베티콜산(OCA)은 일차 담도 담관염(PBC)을 전형적으로 우르소데옥시콜산과 조합하거나 일부 환자에서 단일 치료 레지멘으로 치료하도록 FDA 승인을 받았다. 또한 PSC 및 NASH의 치료제로 임상 개발 중에 있다. 그러나 OCA는 바람직하지 않은 부작용을 가질 수 있다. FXR 효능제인 오베티콜산은 CDCA와 비교하여 인간 FXR 활성화에 100배 더 강한 것으로 보고된 CDCA의 합성 유도체이다.
비히클에 대한 OCA 및 CDCA의 차별적인 효능을 확인하기 위해 인간 FXR 리포터 세포주를 사용하여 실험을 수행하였다(도 6). 루시퍼라제-기반 분석에서, 리포터 세포는 FXR 활성의 판독과 함께 OCA 또는 CDCA의 연속 희석과 함께 인큐베이션되었다. FXR은 담즙산에 결합한 후 전사 조절인자로 활성화된다. OCA는 CDCA에 비해 거의 100배 더 강력했다. 그런 다음 FXR의 활성화에 대한 CDCA와 OCA의 동시-인큐베이션의 효과를 결정했다. 놀랍게도, CDCA의 EC50 (50 uM)의 첨가는 OCA의 FXR 활성에 영향을 미쳤다. CDCA의 존재 하에서, OCA 용량-반응 곡선은 약 20배로 이동된 상태로 유지되었고, 이는 CDCA를 OCA에 첨가하면 OCA 효능을 증가시킬 수 있음을 나타낸다(도 6a).
현재 OCA 투약 표준과 관련된 부작용을 감안할 때, 저용량의 OCA는 효과적인 치료를 제공하면서도 환자 경험을 상당히 개선할 수 있다. 담즙산 공동 처리가 생체내에서 OCA 효능을 개선시키는지를 결정하기 위해, 먼저 마우스 모델에서 관심있는 OCA 및 담즙산의 효과적인 FXR 신호전달을 위한 용량 범위를 확인하였다. 마우스에서, 케노데옥시콜산은 담즙산 풀의 중요하지 않은 부분을 구성하는 반면, 콜산(CA)은 FXR에 대한 보다 강력한 리간드인 것으로 보인다(Song 등, Tox.Appl.Pharmacol.283:57-64, 2015). 따라서, OCA의 용량 범위 뿐만 아니라 고정된 농도의 CA를 마우스에서 FXR 신호전달에 대한 그의 효과에 대해 시험하였다. CYP7A1(간) 및 FGF-15(회장)의 발현에 기초하여 회장 및 간 FXR 신호전달을 모니터링하였다. OCA 투여는 CYP7A1 발현의 용량 의존적 감소 및 FGF-15 수준의 증가를 초래하였으며(도 6c~d), 간 및 회장에서 FXR을 통한 효과적인 신호전달을 시사한다. 콜산 보충 식이는 또한 CYP7A1 발현을 감소시키고, 회장내 FGF-15 수준을 증가시켰으며, 이는 CA 보충과 함께 FXR 활성화를 시사한다(도 6b).
본 발명자들은 다음으로 OCA와 콜산의 공동 처리가 FXR을 통한 OCA 신호전달의 효능을 향상시켜 효과적인 치료에 필요한 OCA의 유효 농도를 낮출 수 있는지를 결정하였다. UDCA 치료에 반응하는 PBC 환자에서, OCA는 3개월 후 반응이 없을 때 투약량을 10 mg으로 증가시킬 수 있는 옵션으로 5 mg의 1일 1회 용량으로 권장된다. 이러한 농도에서의 투약은 부작용, 특히 소양증과 연관되어 있다. 콜산(CA) 또는 케노데옥시콜산(CDCA)과 같은 일차 담즙산을 생성하는 미생물군집 조성물로 OCA의 효능 을 증가시키면, 낮은 용량에서도 동등한 효능을 얻을 수 있으며, 효과적인 치료를 달성하면서 OCA-관련된 부작용을 경감시킬 수 있다. 투약량 또는 빈도의 감소는 또한 OCA로의 치료를 성공적으로 용인할 수 있는 환자의 수를 증가시켜서 더 넓은 모집단에게 치료를 제공할 수 있다.
이러한 발견을 고려하여, 일부 구현예에서, 본 발명은 OCA 치료를 받는 환자에게 투여되는 경우 CDCA 및/또는 콜산을 증가시킬 수 있는 박테리아 조성물에 관한 것이다. 일부 경우에, 조성물은 또한 HSDH 및 7α-디하이드록실화 활성을 조절(예를 들어, 감소)할 수 있다.
CDCA는 용량 의존 방식으로 비-활성 히오콜산의 효능을 향상시킨다
히오콜산(HCA; 6-a-하이드록시 무리콜산이며; OCA는 6-α-에틸 콜산임)은 태아 담즙에 중도 수준으로 존재하고 성인 인간에서 더 낮은 수준으로 존재하는 것으로 보고된 담즙산이다(Setchell 등, J. Biol. Chem.263: 16637-16644,1988). HCA에는 알려진 기능 특성이 없다. 상기 기재된 시험관내 리포터 분석을 사용하여, 출원인은 HCA가 hFXR 효능제 활성을 갖는지 여부를 시험하였다. 결과는 도 8에 도시되어 있다.
이들 실험에서, HCA 단독은 CDCA의 농도와 비교하여 최대 200 uM의 농도에서 인간 FXR 효능제 활성을 갖지 않았으며, 비교적 약한 효능제인 LCA 및 DCA보다 더욱더 적은 활성이었다(도 7a). 놀랍게도, 50 uM CDCA의 존재하에, HCA는 용량-의존적이고 상승작용 방식으로 인간 FXR을 활성화시켰다(도 7b). 이 효과는 DCA 또는 LCA와 조합된 CDCA에서는 보이지 않았으며, 이는 hFXR 효능제 활성을 보다 부가적인 방식으로 상향조절하였지만; LCA와의 병용은 더 높은 농도(100 μM)에서 독성을 나타냈다(아래 그래프). 임의의 특정 이론을 고수하지 않으면서, CDCA는 6-α 위치에서 변형된 담즙산을 강화시킬 수 있다.
이들 데이터는 CDCA 및/또는 HCA를 상향 조절할 수 있는 박테리아 조성물이 담즙정체성 질환을 치료하기 위해 내인성 FXR 신호전달을 향상시키는 데 사용될 수 있음을 나타낸다.
실시예 3: 담즙정체성 질환의 쥣과 모델 치료
MDR2 유전자가 결여된 마우스는 담즙정체성 질환을 발생시킨다(Tabibian 등, Hepatology 63 (1):185-196, 2016). 무균 MDR2-/- 마우스는 아마도 미생물군집 합성된 일차 및 이차 담즙산의 결여에 더하여 적절한 양의 포스파티딜콜린이 결여된 담즙으로부터의 담관세포 독성 때문에 아마도 더 신속하고 심각한 담즙정체증이 발생한다. 일차 담즙산염을 탈접합할 수 없거나 이차 담즙산(상기와 같은 무-BSH 및 BSH-단독 조성물)을 만들 수 없는 박테리아로 이들 마우스를 군집화하고, 이차 담즙산의 전체 스위트(상기와 같은 Max BA)를 만들 수 있는 미생물군집으로 군집화된 마우스와 질환의 진행을 비교하여, 미생물군집으로의 개입을 통해 담즙정체증의 진행을 제어하는 능력을 입증한다.
무균 mdr2-/- 마우스는 또한 담즙정체성 질환 또는 담즙정체성 질환 증상을 개선하기 위한 특정 조성물의 효능을 모델링하는데 사용될 수 있다. BA 활성이 없는 조성물과 같이 보호가 잘되지 않는 미생물군집으로 군집화된 마우스 모델은 담즙산 대사를 향상시킬 수 있는 조성물, 예를 들어 BSH 활성 단독 조성물 또는 Max BA 활성 조성물로 그러한 마우스를 군집화하는 것에 비해 질환을 더 빠르게 또는 더 크게 발생시킬 것으로 예상된다. 이러한 조성물은 마우스 모델을 사용하여 평가되어, 담즙정체성 질환의 진행 및 중증도에서 일차 및/또는 이차 담즙산 대사를 증가시킬 수 있는 조성물의 효과를 모니터링한다. 이러한 조성물의 평가에 유용한 무균 개입 마우스 모델은 무균 mdr2-/- 결실 모델 또는 야생형 마우스에서 담즙정체성 질환의 DDC-유도된 화학적 모델을 포함한다(예를 들어, Fickert 등, Am. J. Pathol.171:525-536, 2007). 종래의 mdr2-/- 마우스에서의 항생제 치료는 항생제를 사용하여 기능이상 미생물군집을 고갈시킨 다음 보호성 조성물로 대체하는 추가 모델로서 사용될 수 있다. BSH 단독 또는 Max BA 조성물과 같은 이차 담즙산 대사를 개선할 수 있는 미생물군집은 질환의 진행을 늦추고 기존의 담즙정체성 질환의 중증도를 감소시킬 수 있다.
실시예 4:
PSC 환자의 이차 담즙산 수준 감소
원발성 경화 담관염(PSC)에서 담관의 막힘은 환자의 간담도계 및 말초 조직에서 담즙산 농도의 유의미한 변화를 초래하여 간에서의 신호전달 및 조직 손상을 초래하는 것으로 생각된다(Chazouillers, Clin.Res. Hepatol.Gasteroentrology 36:S21-S25, 2012). Trottier 등 (Trottier 등, Dig.Liver Dis. 44:303-310, 2012)는 PSC 환자의 말초 혈청에서 이차 담즙산의 감소와 함께 총 담즙산의 유의미한 증가가 있음을 보여주었다. 그러나, 담즙 또는 관문 혈청과 같은 간담도 순환에 연결된 시스템에서 담즙산 수준의 변화는 특징이 잘 드러나지 않는다. 여기, 본 발명자들은 7명의 PSC(말기 간 질환) 환자에서 관문, 담즙 및 말초 혈청 25개의 독특한 담즙산을 프로파일링하였다. 이 측정 값은 12명의 건강한 공여체의 측정 값과 비교하였으며, 담즙정체성 간 질환 환자에서 담즙산의 총 수준뿐만 아니라 조성물의 상당한 변화를 보여주었다.
총 담즙산 수준은 말초 혈청에서 상당히 상승했으며, 건강한 공여체와 비교하여 관문 혈액에서 증가했다(도 8a). 대조적으로, 담즙의 총 담즙산 수준은 PSC 환자에서 상당히 낮았으며, 이는 간 담낭에서 담즙의 흐름이 감소하고 담관의 차단을 나타낸다(도 8a). 혈청에서 담즙산의 상응하는 증가는 결과적으로 혈청으로 유출된 간내 담즙산의 축적을 반영할 수 있다. 그들의 구성성분 담즙산 그룹으로 분해될 때, 접합된 및 비접합된 미생물-유래된 이차 담즙산의 수준은 말초 및 관문 혈청 및 담즙에서 감소되었다(도 8b). 여기에는 7α-디하이드록실화 및 HSDH와 같은 미생물-촉매접촉된 활성에 의해 생성된 담즙산이 포함되었다. 소화관에서 미생물 BSH 활성에 의해 생성된 비접합된 일차 담즙산은 말초 혈청에서 감소하고, 관문 혈청에서도 더 적게 감소했다. 이러한 변화는 간에 의해 합성된 업스트림 접합된 일차 담즙산의 증가를 동반하였고, 이는 소화관 미생물군집에 의해 촉매접촉된 일차 및 이차 담즙산 대사 경로의 손상을 시사한다. 미생물군집 합성 담즙산에서의 이러한 감소는 간 질환 환자에서 변경된 미생물군집 및 잠재적으로 간에서의 신호전달 손상을 시사한다.
담즙정체성 질환의 마우스 모델은 인간 PSC 환자와 비슷한 담즙산 프로파일의 변화를 보여준다
보다 빠른 DDC-식이 유도 담즙정체증 모델뿐만 아니라 1년에 걸쳐 질환을 발생시키는 mdr2-/- 결실 모델인 2개의 마우스 모델이 현재 담즙정체성 간 질환의 진행을 연구하는데 이용되고 있다. DDC-식이 모델은 최근 담즙정체성 질환의 유전자 mdr2-/- 녹아웃 모델에 대한 대안으로서 공개되었다(Fickert 등, Am. J. Pathol.171(2): 525-536, 2007). 이 모델은 PSC 환자에서 전형적으로 보이는 담관의 막힘을 입증하고, PSC에서 담즙정체성 질환과 연관된 상승된 ALP 및 ALT 혈청 수준을 보여준다. 그러나, 마우스에서 담즙산 대사에 대한 DDC-식이 유도성 담즙정체성 질환의 효과는 알려져 있지 않다.
담즙산 함량의 변화를 평가하기 위해, 종래에 하우징된 C57Bl/6 마우스를 DDC-식이 상에 놓고 체중 감소를 모니터링하였다. 체중 감소, 혈청 생화학 및 전반적인 건강 상태에 기초하여 질환 중증도를 평가하였다. 21일의 치료에서, DDC 식이에서 마우스는 ALP, ALT, 총 빌리루빈 및 콜레스테롤의 상승된 수준을 나타내며(도 9a), 담즙정체성 질환의 발병을 확인시켜준다. 이어서, 이들 마우스로부터의 배설물, 간 및 관문 혈액 샘플을 건강한 미처리 대조군과 비교하여 담즙산 함량에 대해 평가하였다.
DDC 식이로 처리된 마우스는 배설물, 간 및 관문 샘플에서 비접합된 및 접합된 이차 담즙산의 상대 존재비가 감소하는(도 9b~d, 2º, Conj.2º), 위에서 특성규명된 PSC 환자에서 관찰된 것과 유사한 경향을 실증하였다(도 8). 미생물 유래된 이차 담즙산의 이러한 감소는 다시 담즙정체성 질환을 갖는 소화관 미생물군집에 대한 변경을 제안하였다. 소화관 미생물군집에 대한 간 질환의 영향을 결정하기 위해, 본 발명자들은 16S NGS 서열분석을 사용하여 담즙정체성 질환(DDC-처리) 전(0일째) 및 후(21일째)의 마우스의 배설물 미생물 함량을 프로파일링하였다. 담즙정체성 간 질환이 있는 마우스는 Shannon 다양성 지수에 기초하여 알파 다양성이 상당히 감소한 것으로 나타났으며, 이는 질환 발생에 따른 종 풍부도의 손실을 시사한다(도 9e). 베타-다양성의 평가는 또한 간 질환이 있는 마우스에서 미생물군집의 구성에서 상당한 변화를 나타내었고(도 9e), 담즙정체성 마우스의 미생물군집은 PCoA 플롯에서 건강한 마우스의 미생물군집과 뚜렷한 클러스터를 형성한다. 도 10f는 마우스에서 간 질환의 발달로 유병률이 상당히 (p ≤ 0.2) 변경된 종을 열거한다. 수많은 종의 상당한 고갈에 추가하여, 시험관내 분석에 기초하여 7α-디하이드록실화 활성을 보유하는 것으로 알려진 특정 균주도 담즙정체성 질환을 갖는 마우스에서 감손되었다(도 9g). 7α-디하이드록실화는 데옥시콜산(DCA)과 리토콜린산(LCA)의 두 가지 주요 이차 담즙산 생산에 필요하다. 이들 동일한 담즙산은 DDC-식이로 처리된 마우스에서도 감손된다(도 10b~10d). 따라서 DDC-마우스 모델의 담즙산 조성물의 변화는 인간의 담즙정체성 질환을 연구하기 위한 비교 모델을 제공한다.
미생물군집의 부재는 담즙정체성 질환에 대한 감수성을 증가시킨다
이전의 연구는 mdr2-/- 결실 모델에서, 미생물군집의 부재는 담즙정체성 간 질환의 더 빠른 발병을 유발시킨다는 것을 보여주었다. 따라서, 담즙정체성 질환의 DDC-식이 유도 모델에서 질환 발생에 대한 미생물군집의 중요성을 먼저 평가하였다. 무균 스위스 알비노 마우스를 무균 DDC 보충식이에 배치하고, 질환 발생을 모니터링하였다. 체중 감소, 혈청 생화학 및 전반적인 건강을 사용하여 질환의 진행을 모니터링하였다. 동시에, 통상적으로 하우징된 스위스 알비노 마우스도 DDC 식이에 배치하였다. 무균 마우스는 통상적인 마우스와 비교하여 빠른 체중 감소(도 10a) 및 간 생화학에 대한 더 심각한 변경(도 10b~d)을 보여, 미생물군집이 간 질환에 대한 내성에 결정적인 역할을 한다는 것을 시사한다.
마우스 유래 FMT에 의한 군집화는 무균 마우스에서 담즙산 대사 및 저항 담즙정체성 질환을 회복시킨다
담즙정체성 질환에 대한 내성에 있어서의 미생물군집의 중요성을 추가로 입증하기 위해, 본 발명자들은 통상적으로 하우징된 스위스 알비노 마우스로부터 유래된 마우스 FMT로 무균 스위스 알비노 마우스를 군집화시켰다. 무균 마우스를 4주 동안 군집화한 후, DDC-보충된 식이로 처리하여 담즙정체성 간 질환을 유발시켰다. FMT로 처리된 마우스는 무균 마우스와 비교하여 더 느린 속도로 질환을 발달시켰으며, DDC-식이에 대한 반응에서 통상적인 마우스와 비교할 수 있었다(도 10). 체중 감소 및 혈청 ALP 수준은 모두 무균 스위스 알비노 마우스에 비해 FMT 군집화된 마우스에서 더 낮았으며, 이는 건강한 미생물군집을 복원하는 것이 DDC-유도된 담즙정체성 간 질환에 대한 내성을 확장하기에 충분하다는 것을 시사한다. 담즙산 프로파일링은 또한 FMT 처리가 무균 마우스와 비교하여 소화관에서 담즙산 조성물을 회복시키기에 충분하다는 것을 결정하였다(도 10e).
미생물 조성물은 담즙정체성 질환에 대한 감수성을 결정한다
통상적인 스위스 알비노 및 C57Bl/6 배경 마우스를 DDC-보충된 식이에 배치할 때, C57Bl/6 배경으로부터의 마우스는 스위스 알비노 마우스에 비해 식이 유도된 간 질환에 더 민감하였다(도 11a~11b). C57Bl/6 마우스는 동일한 연령의 스위스 알비노 마우스에 비해 더 빠른 체중 감소를 나타냈다. 그러나 ALP의 혈청 수준은 비슷한 수준으로 유지되었다. 그러나, 미생물군집이 없는 경우, 무균 스위스 알비노 마우스는 더 이상 내성이 없으며, C57Bl/6 마우스와 비슷한 속도로 질환이 발생했으며(도 11a~11b), 이는 유전적 배경보다는 미생물군집 조성물이 마우스에서 간 질환에 대한 감수성을 결정할 수 있음을 시사한다. 무균 스위스 알비노 및 C57Bl/6 마우스는 유사한 속도로 체중이 감소하고, 혈청에서 ALP 수준이 상승한 것으로 나타났다. C57Bl/6 마우스는 약간 더 높은 ALP 수준을 가졌으며, 이는 그 유전적 배경에서 질환의 추가 진행을 시사한다.
두 유전자적으로 별개의 균주 사이의 미생물군집의 역할을 추가로 비교하기 위해, 본 발명자들은 스위스 알비노 마우스의 DDC-식이 유도된 담즙정체성 질환에 대한 감수성에 대한 C57Bl/6 유래 미생물군집의 효과를 결정하였다. 무균 스위스 알비노 마우스를 C57Bl/6 유래 또는 스위스 알비노-유래된 배설물 미생물군집 이식(FMT)으로 처리하고, 4주 동안 군집화시켰다. 이어서, 마우스를 DDC-보충된 식이(0.1%)에 배치하고, 담즙정체성 질환의 발병을 모니터링하였다. 체중 감소 및 혈청 생화학은 질환의 주요 마커인 반면, 담즙산 대사 및 간 조직학은 미생물군집 기능성 및 질환 발달의 추가 마커로서 사용되었다.
C57Bl/6 유래 FMT로 군집화된 스위스 알비노 마우스는 유사한 혈청 ALP 수준에도 불구하고 스위스 알비노 유래 FMT로 군집화된 마우스(도 11c)에 비해 더 빠른 초기 체중 감소를 나타냈다(도 11d). C57Bl/6 군집화된 마우스는 DDC 식이에 대한 반응에서 무균 마우스와 더 유사 해 보였으나, 스위스 알비노 군집화된 마우스는 그들의 반응에서 통상적인 마우스와 유사하여, 그들의 시작 미생물군집과 질환의 진행 사이의 연관성을 시사한다. 다른 미생물군집의 잠재적인 역할을 추가로 평가하기 위해, 본 발명자들은 C57Bl/6-유래된 FMT로 군집화된 마우스의 배설물 담즙산 프로파일을 DDC 처리 전에 스위스 알비노 유래된 FMT로 군집화된 마우스와 비교하였다. C57Bl/6 공급 FMT로 처리된 마우스는 기준선에서 스위스 알비노 유래된 FMT로 처리된 마우스와 비교하여 유의하게 더 높은 수준의 일차 담즙산 및 더 낮은 수준의 7-알파 디하이드록실화 및 이성질체화 이차 담즙산을 가졌다(도 11e). 이것은 2개의 미생물군집들(C57Bl/6 대 스위스 알비노) 사이의 대사 활동에서 유의한 차이를 나타내며, 두 마우스 균주 사이에서 보여지는 감수성의 차이를 설명할 수 있다. 보다 민감한 C57Bl/6 FMT 군집화된 마우스에서 이차 담즙산의 고갈은 PSC 환자(도 8) 및 담즙정체증의 마우스 모델(도 9)에서 보이는 이차 담즙산의 손실을 모방하며, 담즙정체성 간 질환의 진행에서 미생물 담즙산 대사를 위한 역할에 집중한다.
설계된 조성물로 미생물 담즙산 대사를 회복시키는 것은 무균 마우스의 담즙정체성 질환에 대한 감수성을 구제한다
상기 결과는 DDC-식이 유도된 간 질환에 대한 보호에서 미생물군집에 대한 중요한 역할을 나타낸다. 특히, 간 질환 진행에 따른 담즙산 대사의 변화, 및 이차 담즙산 수준이 감소된 마우스에서 간 질환에 대한 증가된 감수성은 담즙정체성 간 질환에 대한 반응에서 미생물 담즙산 대사 및 담즙산 자체에 대한 역할을 시사한다.
도 3에 도시된 바와 같이, 박테리아 조성물은 마우스 소화관의 담즙산을 재구성하여, 미생물 담즙산 대사를 구체적으로 회복시키도록 설계될 수 있다. 본 발명자들은 DDC-식이-유도된 모델 담즙정체증에서 간 질환으로부터 무균 마우스를 보호하는데 있어서, 이러한 하나의 조성물, Max BA(도 2 및 3)의 효능을 시험하였다. Max BA 조성물은 BSH, 7α-디하이드록실화 및 HSDH를 포함한 모든 주요 담즙산 대사 활성을 회복시키도록 설계되었다(도 1). 무균 마우스를 Max BA 조성물로 처리하고, 4주 동안 군집화시켰다. 이어서, 군집화된 마우스를 DDC 보충된 식이에 노출시키고, DDC 식이에 노출된 무균 및 통상적인 대조군과 비교하여 간 질환의 발병을 모니터링하였다. Max BA 조성물로 처리된 마우스는 DDC 식이에서 비군집화된 무균 마우스와 비교하여 체중 감소 속도가 더 느리고 혈청 ALP 수준이 낮게 유지되었으며(도 12a~12b), Max BA 조성물이 존재하는 경우 질환의 진행이 느리다는 것을 시사한다. 설계된 박테리아 조성물에 의한 군집화는 FMT 치료만큼 효과적이었으며, DDC 처리에 의한 간 질환 진행률을 감소시키는 데 있어서 통상적인 마우스와 비교할 수 있었다.
이러한 발견을 고려하여, 일부 구현예에서, 본 발명은 담즙정체성 질환으로 진단된 환자에게 투여될 때 일차 및 이차 담즙산의 수준을 회복시킬 수 있는 박테리아 조성물에 관한 것이며, 예를 들어 이러한 조성물로의 치료는 일차 및 이차 담즙산이 건강한 인간에게서 관찰되는 범위 내의 수준으로 존재하도록 초래할 수 있다.
mFMT에 의한 군집화는 무균 mdr2-/-C57Bl/6 마우스에서 조기 치사를 구제한다.
Tabiban 등 (Tabiban 등, Hepatol.63: 185-196, 2015)는 이전에 FVB 유전적 배경에서 무균 mdr2-/- 마우스가 종래의 mdr2-/- 마우스와 비교하여 더 빠른 속도로 및 큰 중증도로 간 질환을 발생시키는 것으로 밝혔다. 본 발명자들은 DDC-식이 유도된 담즙정체성 질환 모델에서 담즙정체성 질환에 더 민감한 것으로 입증된 유전자 배경인, mdr2-/- 결실을 갖는 C57Bl/6 마우스를 사용하기로 선택하였다(도 11). C57Bl/6 배경에서 mdr2-/- 결실 돌연변이체의 무균 유도는 조기 치사를 초래하였으며, 생존한 새끼는 4주령에 도달하기 전에 심각한 질환 및 치사를 나타냈다.
DDC-식이 유도된 담즙정체성 질환 모델에서 무균 마우스의 감수성을 구제하는데 있어서 마우스-유래 FMT의 실증된 효과를 고려하여(도 10), C57Bl/6 유전자 배경의 무균 mdr2-/- 마우스의 생존에 대한 FMT 처리의 효과를 결정하였다. 새끼가 2주령되었을때 침구 및 케이지에 따라 마우스 FMT로 위탁모에게 군집화하였다. FMT 군집화는 12주 이상 동안 처리된 mdr2-/- 강아지에서 100% 생존율을 수득한 반면, 무균 상태로 남아있는 처리되지 않은 강아지는 4주령 이내에 치사율을 나타냈다. mdr2-/- 무균 마우스의 생존에 대한 군집화의 상당한 효과는 담즙정체성 간 질환을 개선시키는데 있어서 미생물군집의 역할을 추가로 지적한다. 담즙산 활성이 없는 시험 조성물(BA 없음)은 소화관내 담즙산 활성의 대부분을 재구성(Max BA)하는 것과 비교하여 담즙정체성 간 질환의 진행을 조절하는데 담즙산의 특정 역할에 대한 통찰력을 제공할 것이다.
담즙산 보충은 무균 마우스의 DDC-식이 유도된 간 질환에 대한 내성을 증가시키기에 충분하다.
본 발명자들은 다음 미생물군집의 부재하에 DDC-식이 유도된 간 질환의 진행에 일차 및 이차 담즙산 보충의 특정 역할을 탐구하였다. 무균 마우스에 일차(CA + CDCA) 또는 이차(DCA + LCA) 담즙산이 보충된 식이를 1주일 동안 공급한 후 DDC 처리에 노출시켰다. 담즙산 보충은 DDC 처리와 함께 계속되어 신호전달을 유지했다. DDC 식이에서 무균 및 통상적인 대조군과 비교하여 체중 감소 및 혈청 생화학에 기초한 간 질환 진전 속도에 대해 마우스를 모니터링하였다.
DDC 노출 후 7일째에, 예비 체중 분석은 DCA + LCA 보충 식이를 공급받은 마우스가 DDC 식이에서 통상적인 마우스에 비해 체중 감소 속도가 상당히 느리다는 것을 보여주었다(도 13). DCA + LCA 보충 식이의 마우스는 DDC 식이의 통상적인 마우스에서 77%와 비교하여 평균 87% 체중 감소를 나타낸다. 이것은 또한 DDC에서 보다 민감한 무균 마우스에서 체중 감소 속도에 비해 현저한 개선을 구성한다. 이것은 심지어 미생물군집이 없는 경우에도 간 질환에 대한 감수성 조절에서 이차 담즙산 신호전달에 중요한 역할을 시사한다. 소화관에서 DCA 및 LCA 수준을 구체적으로 회복시킴으로써 이들 효과를 모방하는 조성물은 간 질환의 진행을 상당히 감소시킬 수 있다. 지속적인 분석은 DCA + LCA 식이의 지속 효과뿐만 아니라 일차 담즙산, 콜산 및 케노데옥시콜산이 보충된 식이의 효과를 평가할 것이다.
이러한 발견을 고려하여, 일부 구현예에서, 본 발명은 담즙정체성 질환으로 진단된 환자에게 투여되는 경우, DCA 및 LCA 수준 및/또는 콜산을 증가시킬 수 있는 박테리아 조성물에 관한 것이다.
미생물 담즙산 활성은 DDC-식이 유도 담즙정체성 간 질환에 대한 내성에 기여한다
이차 담즙산 대사를 회복하는 능력이 간 질환에 대한 감수성에 대한 미생물군집의 유익한 효과에 필요한지 여부를 결정하기 위해, 마우스는 모든 미생물 담즙산 활성이 결여된 박테리아 균주로 구성된 설계된 조성물로 처리된다(무 BA, 도 1). 이 조성물은 소화관에서 담즙산을 변형시킬 수 없으며, 군집화된 마우스는 무균 마우스와 동일한 담즙산 조성물을 유지할 것이다. 이 실험에서, 마우스는 무 BA 조성물, (2º 담즙산 대사를 회복시키는) Max BA 조성물 또는 마우스 유래된 FMT로 처리하고, 4주 동안 군집화한다. 군집화된 마우스를 DDC-보충 식이에 배치하고, 체중 감소 및 혈청 생화학에 기초하여 간 질환의 발달을 모니터링한다. Max BA 또는 FMT 마우스와 비교하여 무 BA 군집화된 마우스에서 질환의 더 빠른 진행은 담즙정체성 간 질환에 대한 미생물군집 내성에 의해 일차 및 이차 담즙산의 생성에 대한 역할을 시사할 것이다.
실시예 5: 담즙산 대사 활성을 갖는 균주를 확인하기 위한 유전자 상동성 검색 방법의 사용
균주의 전체 게놈 서열에 기초하여 담즙산 대사 활성 잠재력을 갖는 균주를 확인하는데 사용될 수 있는 유전자 상동성 검색 방법의 2가지 예는 하기와 같이 기술된다. 한 방법에서, 균주의 전체 게놈 서열로부터의 단백질-코딩 영역은 BLASTp와의 원하는 담즙산 활성을 촉매하는 공지된 특성규명된 단백질의 데이터베이스와 비교하여 쌍별로; 데이터베이스의 임의의 단백질과 충분한 유사성을 갖는 단백질을 함유하는 균주가 원하는 담즙산 활성을 추정적으로 보유하는 것으로 확인된다. 두 번째 방법에서, 균주의 전체 게놈 서열로부터의 단백질-코딩 영역은 원하는 담즙산 활성을 촉매하는 공지된 특성규명된 단백질의 다중 서열 정렬로부터 유래된 프로파일 히든 마르코프 모델(HMM)과 비교하여; 프로파일 HMM과 충분히 유사한 단백질을 함유하는 균주는 원하는 담즙산 활성을 추정적으로 보유하는 것으로 확인될 수 있다. 서열 데이터베이스, 프로파일 HMM 및 적절한 유사성 컷오프의 세부사항은 질의되는 담즙산 활성에 따라 다르며, 이는 하기에 기재되어 있다.
도 14는 BSH 활성의 생체정보 예측을 시험관내 분석된 활성과 비교한 결과를 보여준다. 시험관내에서 스크리닝되고 이용가능한 전체 게놈 서열을 갖는 모든 균주가 고려된다. 좌측 플롯은 LC-MS에 의해 시험관내 스크리닝된 균주를 고려하는 반면, 우측 플롯은 TLC에 의해 스크리닝된 균주를 고려한다. 두 플롯 모두 해당 균주의 게놈에서 BSH HMM에 대한 가장 중요한 정렬의 e- 값을 보여준다. 게놈 정렬의 유의성은 시험관내 스크린(Mann-Whitney U 테스트; LC-MS의 경우 p=0.02, TLC의 경우 p=0.0005)의 결과와 유의한 상관 관계가 있다. e-값 = 1e-40의 컷오프는 어떤 균주가 BSH 활성을 갖거나 갖지 않을지를 예측하는 데 사용될 수 있으며(점선); 이 분류 컷오프에 대한 결과 혼동 매트릭스가 표시된다(LC-MS 분석 감수성 = 0.86, 특이성 = 0.5, 정확도 = 0.88, p = 0.01; TLC 분석 감수성 = 0.77, 특이성 = 0.63, 정확도 = 0.74, p = 0.0002). TLC 분석 자체의 감수성이 낮기 때문에, 게놈 예측의 오탐율이 과대 평가될 수 있음을 주목한다. 게다가, LC-MS 분석에서 적은 수의 진 음성으로 인해, 게놈 예측의 특이성이 과소 평가될 수 있다.
도 15는 7α-디하이드록실화 활성의 생체정보 예측을 시험관내 분석된 활성과 비교한 결과를 보여준다. 시험관내에서 스크리닝되고 이용가능한 전체 게놈 서열을 갖는 모든 균주가 고려된다. 박스 플롯은 LC-MS에 의해 시험관내 스크리닝된 균주를 고려하지 않았다(어떤 것도 TLC에 의해 스크리닝되지 않음). 두 플롯 모두 해당 균주 게놈에서 BaiE HMM과 가장 유의하게 일치하는 e-값을 보여준다. 게놈 정렬의 유의성은 시험관내 스크린의 결과와 유의한 상관 관계가 있다 (Mann-Whitney U 테스트; p <1e-8). e-값 = 1e-40의 컷오프는 어느 균주가 7α-디하이드록실화 활성을 가질지 또는 갖지 않을지를 예측하는데 사용될 수 있으며(점선); 이 분류 컷오프에 대한 결과 혼동 매트릭스가 표시된다(감수성 = 1.0, 특이도 = 1.0, 정확도 = 1.0, p <1e-5). 진 양성의 수가 적기 때문에 실제 감수성, 특이성 및 정확도가 과대 평가될 수 있다.
다른 구현예는 하기 청구범위의 범위 내에 있다.
SEQUENCE LISTING
<110> Seres Therapeutics, Inc.
<120> COMPOSITIONS AND METHODS FOR TREATING CHOLESTATIC DISEASE
<130> 4268.0430001
<150> PCT/US2018/046769
<151> 2018-08-14
<150> US 62/545,298
<151> 2017-08-14
<160> 311
<170> PatentIn version 3.5
<210> 1
<211> 1532
<212> DNA
<213> Artificial Sequence
<220>
<223> Abiotrophia_defectiva
<400> 1
atgagagttt gatcctggct caggatgaac gctggcggcg tgcctaacac atgcaagtcg 60
aacggagatt acggacggaa gttttcggat ggaagcctgt aattcttagt ggcggacggg 120
tgagtaacgc gtgggcaacc tgccctatac agggggatag cagctggaaa cggctggtaa 180
gaccgcataa gtcggttaaa tcgcatgatt tgatcgggaa atgagcaatc aggtatagga 240
tgggcccgcg tccgattagc cagttggcag ggtaaaagcc taccaaagcg acgatcggta 300
gccggactga gaggtcggac ggccacattg ggactgagac acggcccaaa ctcctacggg 360
aggcagcagt gggggatatt gcacaatgga ggaaactctg atgcagcgac gccgcgtgag 420
tgaagaagta tttcggtatg taaagctcta tcagcaggga agatgatgac ggtacctgac 480
taagaagccc cggctaacta cgcgccagca gccgcggtaa tacgtagggg gcaagcgtta 540
tccggattta ctgggtgtaa agggagcgca ggcggttttg caagttgaga gtggaagcag 600
ggggctcaac cccctgactg ctcccaaaac tgtaaaactt gagtatggga gaggcaggcg 660
gaattcctag tgtagcggtg aaatgcttag atattaggaa gaacaccggt ggcgaaggcg 720
gcctgctgga ccaaaactga cgctgaggct cgaaagcgtg ggtagcaaac aggattagat 780
accctggtag tccacgctgt aaacgatgaa tactaggtgc tgggatgcat aagcatttcg 840
gtgccgtcgc aaacgcatta agtattccac ctggggagta cgttcgcaag aatgaaactc 900
aaaggaattg acggggaccc gcacaagcgg tggagcatgt ggtttaattc gacgcaacgc 960
gaagaacctt acccggtctt gagatcctcc tgaatactga gtaatgtcag tagtccttcg 1020
ggacaggaga gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga tgttgggtta 1080
agtcccgcaa cgagcgcaac ccctattttt agtagccagc ggttcggccg ggcactctaa 1140
agagactgcc gaggataact cggaggaagg cggggatgac gtcaaatcat catgcccctt 1200
atgaccgggg ctacacacgt gctacaatgg cagttacaga gggaagcgaa ggcgtgagcc 1260
ggagcaaatc tcagaaaggc tgcctcagtt cggattgtag tctgcaactc gactacatga 1320
agctggaatc gctagtaatc gcgaatcaga atgtcgcggt gaatacgttc ccgggtcttg 1380
tacacaccgc ccgtcacacc atgggagtcg gaaatgcccg aagtcagtgg cctaaccgta 1440
agggaggagc tgccgaaggc aggtctggtg actggggtga agtcgtaaca aggtagccgt 1500
atcggaaggt gcggctggat cacctccttt ct 1532
<210> 2
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<212> DNA
<213> Artificial Sequence
<220>
<223> Abiotrophia_sp_oral_clone_P4PA
<400> 2
gacgaacgct ggcggtgtgc ctaatacatg caagtcgaac gagtggcgaa cgggtgagta 60
acacgtgggt aacctacctc atagtggggg ataacagtcg gaaacgactg ctaataccgc 120
atagggaaag tcgctaagag atggacccgc ggtgcattag ctggttggta gggtaaaggc 180
ctaccaaggc gatgatgcat agccgacctg agagggtgat cggccacatt gggactgaga 240
ctcggcccag actcctacgg gaggcagcag tagggaatct tccgcaatgg acgcaagtct 300
gacggagcaa cgccgcgtga gtgaagaagg tcttcggatc gtaaagctct gttgttggag 360
aagatgacgg tatctaaccg gaaagccacg gctaactacg tgccagcagc cgcggtaata 420
cgtaggtggc gagcgttgtc cggatttatt gggcgtaaag ggagtgtagg cggtctttta 480
agtctgatgt gaaagcccac ggctcaaccg tggagggtca ttggaaactg ggagacttga 540
gtgcagaaga ggagagcgga attccatgtg tagcggtgaa atgcgtagat atatggagga 600
acaccagtgg cgaaggcggc tctctggtct gactgacgct gaggctcgaa agcgtgggga 660
gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttgga 720
gcttcagtgc tggagttaac gcaataagca ctccgcctgg ggagtacggc cgcaaggctg 780
aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag 840
caacgcgaag aaccttacca ggtcttgaca tcgacaggtg gtgcatggtt gtcgtcagct 900
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccctataa ctagttgcca 960
gcatggggac tctagttaga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 1020
atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggatggc aacgagcagc 1080
gaactcgcga gggtaagcga atctctacca ttctcagttc ggatgtagtc tgcaacccga 1140
ctacagaagc cggaatcgct agtaatcgcg gatcagcacg ccgcggtgaa tacgttcccg 1200
ggtcttgtac acaccgcccg tcacaccacg agagtttgta acacccgaag ccggtgccta 1260
gggagccgtc gaaggtggga tagatgattg gggtgaagtc gtaacaaggt agccgtatcg 1320
gaaggtgc 1328
<210> 3
<211> 1488
<212> DNA
<213> Artificial Sequence
<220>
<223> Aerococcus_sanguinicola
<400> 3
ctcaggacga acgctggcgg catgcctaat acatgcaagt cgagcgaacc gacgaagtgc 60
ttgcacttct gacgttagcg gcggacgggt gagtaacacg taaggaacct acctatgagc 120
gggggacaac atccggaaac gggtgctaat accgcatagt aatttgtcag gcatctgaca 180
aattggaaag acggcttttg ctgtcactca tagatggtct tgcggtgcat tagctagttg 240
gtgggataaa agcttaccaa ggccatgatg catagccgac ctgagagggt aatcggccac 300
actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa tcttccgcaa 360
tgggcgcaag cctgacggag caatgccgcg tgagtgaaga aggttttcgg atcgtaaaac 420
tctgttgtaa gagaagaaca aattgtagag taactgctac agtcttgacg gtatcttacc 480
agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 540
ccggatttat tgggcgtaaa gggagcgcag gtggtttctt aagtctgatg tgaaagccca 600
cggcttaacc gtggagggtc attggaaact gggaaacttg agtgcagaag aggaaagtgg 660
aactccatgt gtagcggtgg aatgcgtaga tatatggaag aacaccagtg gcgaaggcga 720
ctttctggtc tgtaactgac actgaggctc gaaagcgtgg gtagcaaaca ggattagata 780
ccctggtagt ccacgccgta aacgatgagt gctaggtgtt ggagggtttc cgcccttcag 840
tgccgcagtt aacgcattaa gcactccgcc tggggagtac ggccgcaagg ctgaaactca 900
aaggaattga cggggacccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 960
aagaacctta ccaagtcttg acatcctttg accactctag agatagagct ttcccttcgg 1020
ggacaaagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 1080
gtcccgcaac gagcgcaacc cttattgtta gttgccagca tttagttggg cactctagcg 1140
agactgccgg tgacaaaccg gaggaaggcg gggatgacgt caaatcatca tgccccttat 1200
gacttgggct acacacgtgc tacaatggat ggtacaacgg gctgcgaact cgcgagagtc 1260
agcgaatccc ttaaagccat tctcagttcg gattgcaggc tgcaactcgc ctgcatgaag 1320
ccggaatcgc tagtaatcgc ggatcagcac gccgcggtga atacgttccc gggtcttgta 1380
cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taaccttttg 1440
gagccagccg ccgaaggtgg gacagatgat tggggtgaag tcgtaaca 1488
<210> 4
<211> 1546
<212> DNA
<213> Artificial Sequence
<220>
<223> Aerococcus_urinae
<400> 4
atgagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 60
agcgaaccga agaagtgctt gcacttctga cgttagcggc ggacgggtga gtaacacgta 120
aggaacctac cgataagcgg gggacaacat ccggaaacgg gtgctaatac cgcataggaa 180
acaccacctc atggtggtgt ttggaaagac ggctttgctg tcacttatcg atggccttgc 240
ggtgcattag ctcgttggtg gggtaacggc ctaccaaggc aatgatgcat agccgacctg 300
agagggtaat cggccacatt gggactgaga cacggcccaa actcctacgg gaggcagcag 360
tagggaatct tccgcaatgg gcgcaagcct gacggagcaa cgccgcgtga gtgaagaagg 420
ttttcggatc gtaaagctct gttgtaagag aagaacaaat tggagagtaa ctgctccagt 480
cttgacggta tcttaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 540
taggtggcaa gcgttgtccg gatttattgg gcgtaaaggg ggcgcaggcg gtttcttaag 600
tctgatgtga aagcccacgg cttaaccgtg gaagtgcatt ggaaactggg gaacttgagt 660
acagaagagg aaagtggaac tccatgtgta gcggtggaat gcgtagatat atggaagaac 720
accagtggcg aaggcgactt tctggtctgt cactgacgct gaggcccgaa agcgtgggta 780
gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aggtgttgga 840
gggtttccac ccttcagtgc cggagttaac gcattaagca ctccgcctgg ggagtacggc 900
cgcaaggctg aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt 960
taattcgaag caacgcgaag aaccttacca agtcttgaca tcctttgacc actctagaga 1020
tagagctttc ccttcgggga caaagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 1080
gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt attgttagtt gccagcattg 1140
agttgggcac tctagcgaga ctgccggtga caaaccggag gaaggcgggg atgacgtcaa 1200
atcatcatgc cccttatgac ttgggctaca cacgtgctac aatggatggt acaacgagca 1260
gcgaccttgt gaaagcaagc gaatctctta aagccattct cagttcggat tgtagtctgc 1320
aactcgacta catgaagccg gaatcgctag taatcgcgga tcagcacgcc gcggtgaata 1380
cgttcccggg tcttgtacac accgcccgtc acaccacgag agtttgtaac acctgaagtc 1440
ggtgaggtaa cctttggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt 1500
aacaaggtag ccgtaggtga acctgcggct ggatcacctc ctttct 1546
<210> 5
<211> 1419
<212> DNA
<213> Artificial Sequence
<220>
<223> Aerococcus_urinaeequi
<220>
<221> misc_feature
<222> (1092)..(1092)
<223> n is a, c, g, or t
<400> 5
acatgcaagt cgagcgaaca gatgaagtgc ttgcacttct gacgttagcg gcgaacgggt 60
gagtaacacg taaggaatct acctataagc gggggataac attcggaaac gggtgctaat 120
accgcataat atcttcttcc gcatggaagg agattgaaag acggctctgc tgtcacttat 180
agatgacctt gcggtgcatt agttagttgg tggggtaacg gcctaccaag acgatgatgc 240
atagccgacc tgagagggtg atcggccaca ttgggactga gacacggccc aaactcctac 300
gggaggcagc agtagggaat cttccgcaat gggcgaaagc ctgacggagc aatgccgcgt 360
gagtgaagaa ggccttcggg tcgtaaaact ctgttataag agaagaacaa attgtagagt 420
aactgctaca gtcttgacgg tatcttatca gaaagccacg gctaactacg tgccagcagc 480
cgcggtaata cgtaggtggc aagcgttgtc cggatttatt gggcgtaaag ggagcgcagg 540
tggtttctta agtctgatgt gaaagcccac ggcttaaccg tggagggtca ttggaaactg 600
ggaaacttga gtacagaaga ggaatgtgga actccatgtg tagcggtgga atgcgtagat 660
atatggaaga acaccagtgg cgaaggcgac attctggtct gttactgaca ctgaggctcg 720
aaagcgtggg gagcaaacag gattagatac cctggtagtc cacgccgtaa acgatgagtg 780
ctaggtgttg gagggtttcc gcccttcagt gccgcagtta acgcattaag cactccgcct 840
ggggagtacg accgcaaggt tgaaactcaa aggaattgac ggggacccgc acaagcggtg 900
gagcatgtgg tttaattcga agcaacgcga agaaccttac caagtcttga catcctttga 960
ccaccctaga gatagggctt tcccttcggg gacaaagtga caggtggtgc atggttgtcg 1020
tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc ctattattag 1080
ttgccagcat tnagttgggc actctaatga gactgccggt gacaaaccgg aggaaggtgg 1140
ggatgacgtc aaatcagcat gccccttatg acttgggcta cacacgtgct acaatggatg 1200
gtacaacgag tcgcaaaccc gcgagggcaa gcaaatctct taaagccatt ctcagttcgg 1260
attgcaggct gcaactcgcc tgcatgaagc cggaatcgct agtaatcgtg gatcagcacg 1320
ccacggtgaa tacgttcccg ggtcttgtac acaccgcccg tcacaccacg agagtttgta 1380
acacccgaag tcggtgaggt aacctttatg gagccagcc 1419
<210> 6
<211> 1548
<212> DNA
<213> Artificial Sequence
<220>
<223> Aerococcus_viridans
<400> 6
atgagagttt gatcctggct caggacgaac gctggcggca tgcctaatac atgcaagtcg 60
agcgaacaga tgaagtgctt gcacttctga cgttagcggc gaacgggtga gtaacacgta 120
aggaatctac ctataagcgg gggataacat tcggaaacgg gtgctaatac cgcataatat 180
tttcttccgc atggaagaag attgaaagac ggctctgctg tcacttatag atgaccttgc 240
ggtgcattag ttagttggtg gggtaatggc ctaccaagac gatgatgcat agccgacctg 300
agagggtgat cggccacatt gggactgaga cacggcccaa actcctacgg gaggcagcag 360
tagggaatct tccgcaatgg gcgaaagcct gacggagcaa tgccgcgtga gtgaagaagg 420
ccttcgggtc gtaaaactct gttataagag aagaacaaat tgtagagtaa ctgctacagt 480
cttgacggta tcttatcaga aagccacggc taactacgtg ccagcagccg cggtaatacg 540
taggtggcaa gcgttgtccg gatttattgg gcgtaaaggg agcgcaggtg gtttcttaag 600
tctgatgtga aagcccacgg cttaaccgtg gagggtcatt ggaaactggg aaacttgagt 660
acagaagagg aatgtggaac tccatgtgta gcggtggaat gcgtagatat atggaagaac 720
accagtggcg aaggcgacat tctggtctgt tactgacact gaggctcgaa agcgtgggga 780
gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aggtgttgga 840
gggtttccgc ccttcagtgc cgcagttaac gcattaagca ctccgcctgg ggagtacgac 900
cgcaaggttg aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt 960
taattcgaag caacgcgaag aaccttacca agtcttgaca tcctttgacc accctagaga 1020
tagggctttc ccttcgggga caaagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 1080
gtgagatgtt gggttaagtc ccgcaacgag cgcaacccct attattagtt gccagcattt 1140
agttgggcac tctaatgaga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 1200
atcagcatgc cccttatgac ttgggctaca cacgtgctac aatggatggt acaacgagtc 1260
gcaaacccgc gagggcaagc aaatctctta aagccattct cagttcggat tgcaggctgc 1320
aactcgcctg catgaagccg gaatcgctag taatcgtgga tcagcacgcc acggtgaata 1380
cgttcccggg tcttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 1440
ggtgaggtaa cctttatgga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 1500
gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttct 1548
<210> 7
<211> 1446
<212> DNA
<213> Artificial Sequence
<220>
<223> Alistipes_finegoldii
<400> 7
gatgaacgct agcggcaggc ttaacacatg caagtcgagg ggcagcacga ggtagcaata 60
ctttggtggc gaccggcgca cgggtgcgta acgcgtatgc aacctacctt taacaggggc 120
ataacactga gaaattggta ctaattcccc ataacattcg agaaggcatc ttcttgggtt 180
aaaaactccg gtggttaaag atgggcatgc gttgtattag ctagttggtg aggtaacggc 240
tcaccaaggc aacgatacat agggggactg agaggttaac cccccacatt ggtactgaga 300
cacggaccaa actcctacgg gaggcagcag tgaggaatat tggtcaatgg acgcaagtct 360
gaaccagcca tgccgcgtgc aggaagacgg ctctatgagt tgtaaactgc ttttgtacta 420
gggtaaacgc tcttacgtgt aggagcctga aagtatagta cgaataagga tcggctaact 480
ccgtgccagc agccgcggta atacggagga tccaagcgtt atccggattt attgggttta 540
aagggtgcgt aggcggtttg ataagttaga ggtgaaatac cggggctcaa ctccggaact 600
gcctctaata ctgttgaact agagagtagt tgcggtaggc ggaatgtatg gtgtagcggt 660
gaaatgctta gagatcatac agaacaccga ttgcgaaggc agcttaccaa actatatctg 720
acgttgaggc acgaaagcgt ggggagcaaa caggattaga taccctggta gtccacgcag 780
taaacgatga taactcgttg tcggcgatac acagtcggtg actaagcgaa agcgataagt 840
tatccacctg gggagtacgt tcgcaagaat gaaactcaaa ggaattgacg ggggcccgca 900
caagcggagg aacatgtggt ttaattcgat gatacgcgag gaaccttacc cgggcttgaa 960
agttagtgac gattctggaa acaggatttc ccttcggggc acgaaactag gtgctgcatg 1020
gttgtcgtca gctcgtgccg tgaggtgtcg ggttaagtcc cataacgagc gcaaccccta 1080
ccgttagttg ccatcaggtc aagctgggca ctctggcggg actgccggtg taagccgaga 1140
ggaaggtggg gatgacgtca aatcagcacg gcccttacgt ccggggctac acacgtgtta 1200
caatggtagg tacagagggc cgctaccccg cgaggggatg ccaatctcga aagcctatct 1260
cagttcggat cggaggctga aacccgcctc cgtgaagttg gattcgctag taatcgcgca 1320
tcagccatgg cgcggtgaat acgttcccgg gccttgtaca caccgcccgt caagccatgg 1380
aagctggggg tgcctgaagt tcgtgaccgc aaggagcgac ctagggcaaa accggtgact 1440
ggggct 1446
<210> 8
<211> 1495
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_acidifaciens
<400> 8
tatcatggct caagatgaac gctagctaca ggcttaacac atgcaagtcg aggggcagca 60
tgaaagtttg cttgcaaact tttgatggcg accggcgcac gggtgagtaa cacgtatcca 120
acctgcctca tactcgggga tagcctttcg aaagaaagat taatacccga tgtcatagtc 180
ctaccgcatg atgggattat taaagaattt cggtatggga tggggatgcg ttccattagt 240
tagttggcgg ggtaacggcc caccaagaca acgatggata ggggttctga gaggaaggtc 300
ccccacattg gaactgagac acggtccaaa ctctacggga ggcagcagtg aggaatattg 360
gtcaatggac gagagtctga accagccaag tagcgtgaag gatgactgcc ctatgggttg 420
taaacttctt ttatatggga ataaaatgtt ccacgtgtgg gattttgtat gtaccatatg 480
aataaggatc ggctaactcc gtgccagcag ccgcggtaat acggaggatc cgagcgttat 540
ccggatttat tgggtttaaa gggagcgtag gtggattgtt aagtcagttg tgaaagtttg 600
cggctcaacc gtaaaattgc agttgaaact ggcagtcttg agtacagtag aggtgggcgg 660
aattcgtggt gtagcggtga aatgcttaga tatcacgaag aactccgatt gcgaaggcag 720
ctcactggac tgcaactgac actgaggctc gaaagtgtgg gtatcaaaca ggattagata 780
ccctggtagt ccacacagta aacgatgaat actcgctgtt tgcgatatac ggcaagcggc 840
caagcgaaag cattaagtat tccacctggg gagtacgccg gcaacggtga aactcaaagg 900
aattgacggg ggccgcacaa gcggaggaac atgtggttta attcgatgat acgcgaggaa 960
ccttacccgg gcttaaattg cacctgaata atgtggaaac atgttagccg taaggcaggt 1020
gtgaaggtgc tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata 1080
acgagcgcaa cccttatctt cagttactaa caggtcatgc tgaggactct ggagagactg 1140
ccgtcgtaag atgtgaggaa ggtggggatg acgtcaaatc agcacggccc ttacgtccgg 1200
ggctacacac gtgttacaat gggaggtaca gaaggccgct acctggcgac aggatgccaa 1260
tccccaaaac ctctctcagt tcggatcgaa gtctgcaacc cgacttcgtg aagctggatt 1320
cgctagtaat cgcgcatcag ccatggcgcg gtgaatacgt tcccgggcct tgtacacacc 1380
gcccgtcaag ccatgaaagc cgggggtacc tgaagtacgt aaccgcaaga tcgtcctagg 1440
gtaaaactgg taattggggc taagtcgtaa caaggtagcc gtaccggaag gtgcg 1495
<210> 9
<211> 1422
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_caccae
<220>
<221> misc_feature
<222> (179)..(181)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (901)..(901)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1006)..(1006)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1420)..(1420)
<223> n is a, c, g, or t
<400> 9
atgaacgcta gctacaggct taacacatgc aagtcgaggg gcatcagttt gtttgcttgc 60
aaacaaacgc tggcgaccgg cgcacgggtg agtaacacgt atccaaccta cctcatactc 120
ggggatagcc tttcgaaaga aagattaata tccgatagca tatatttccc gcatgggtnn 180
natattaaag aaattcggta tgagatgggg atgcgttcca ttagtttgtt gggggggtaa 240
cggcccacca agactacgat ggataggggt tctgagagga aggtccccca cattggaact 300
gagacacggt ccaaactcct acgggaggca gcagtgagga atattggtca atggacgcga 360
gtctgaacca gccaagtagc gtgaaggatg actgccctat gggttgtaaa cttcttttat 420
atgggaataa agtggtccac gtgtggactt ttgtatgtac catatgaata aggatcggct 480
aactccgtgc cagcagccgc ggtaatacgg aggatccgag cgttatccgg atttattggg 540
tttaaaggga gcgtaggcgg attgttaagt cagttgtgaa agtttgcggc tcaaccgtaa 600
aattgcagtt gatactggca gtcttgagtg cagtagaggt gggcggaatt cgtggtgtag 660
cggtgaaatg cttagatatc acgaagaact ccgattgcga aggcagctca ctggagtgta 720
actgacgctg atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac 780
acagtaaacg atgaatactc gctgtttgcg atatacagta agcggccaag cgaaagcatt 840
aagtattcca cctggggagt acgccggcaa cggtgaaact caaaggaatt gacgggggcc 900
ngcacaagcg gaggaacatg tggtttaatt cgatgatacg cgaggaacct tacccgggct 960
taaattgcaa atgaattatg gggaaaccca tacgccgcaa ggcatntgtg aaggtgctgc 1020
atggttgtcg tcagctcgtg ccgtgaggtg tcggcttaag tgccataacg agcgcaaccc 1080
ttatcttcag ttactaacag gtcatgctga ggactctgga gagactgccg tcgtaagatg 1140
tgaggaaggt ggggatgacg tcaaatcagc acggccctta cgtccggggc tacacacgtg 1200
ttacaatggg gggtacagaa ggcagctacc tggtgacagg atgccaatcc caaaaacctc 1260
tctcagttcg gatcgaagtc tgcaacccga cttcgtgaag ctggattcgc tagtaatcgc 1320
gcatcagcca tggcgcggtg aatacgttcc cgggccttgt acacaccgcc cgtcaagcca 1380
tgaaagccgg gggtacctga agtacgtaac cgcaaggagn gt 1422
<210> 10
<211> 1521
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_caccae
<400> 10
gtttgatcct ggctcaggat gaacgctagc tacaggctta acacatgcaa gtcgaggggc 60
atcagtttgg tttgcttgca aaccaaagct ggcgaccggc gcacgggtga gtaacacgta 120
tccaacctac ctcatactcg gggatagcct ttcgaaagaa agattaatat ccgatggcat 180
atatttcccg catgggtttt atattaaaga aattcggtat gagatgggga tgcgttccat 240
tagtttgttg ggggggtaac ggcccaccaa gactacgatg gataggggtt ctgagaggaa 300
ggtcccccac attggaactg agacacggtc caaactccta cgggaggcag cagtgaggaa 360
tattggtcaa tggacgcgag tctgaaccag ccaagtagcg tgaaggatga ctgccctatg 420
ggttgtaaac ttcttttata tgggaataaa gtggtccacg tgtggacttt tgtatgtacc 480
atatgaataa ggatcggcta actccgtgcc agcagccgcg gtaatacgga ggatccgagc 540
gttatccgga tttattgggt ttaaagggag cgtaggcgga ttgttaagtc agttgtgaaa 600
gtttgcggct caaccgtaaa attgcagttg atactggcag tcttgagtgc agtagaggtg 660
ggcggaattc gtggtgtagc ggtgaaatgc ttagatatca cgaagaactc cgattgcgaa 720
ggcagctcac tggagtgtaa ctgacgctga tgctcgaaag tgtgggtatc aaacaggatt 780
agataccctg gtagtccaca cagtaaacga tgaatactcg ctgtttgcga tatacagtaa 840
gcggccaagc gaaagcatta agtattccac ctggggagta cgccggcaac ggtgaaactc 900
aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc gatgatacgc 960
gaggaacctt acccgggctt aaattgcaaa tgaattatgg ggaaacccat acgccgcaag 1020
gcatttgtga aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt cggcttaagt 1080
gccataacga gcgcaaccct tatcttcagt tactaacagg tcatgctgag gactctggag 1140
agactgccgt cgtaagatgt gaggaaggtg gggatgacgt caaatcagca cggcccttac 1200
gtccggggct acacacgtgt tacaatgagg ggtacagaag gccgctacct ggtgacagga 1260
tgccaatccc aaaaacctct ctcagttcgg atcgaagtct gcaacccgac ttcgtgaagc 1320
tggattcgct agtaatcgcg catcagccat ggcgcggtga atacgttccc gggccttgta 1380
cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtacgtaacc gcaaggagcg 1440
tcctagggta aaactggtaa ttggggctaa gtcgtaacaa ggtagccgta ccggaaggtg 1500
cggctggaac acctcctttc t 1521
<210> 11
<211> 1531
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_eggerthii
<400> 11
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatgat tgaagcttgc ttcaatcgat ggcgaccggc gcacgggtga 120
gtaacacgta tccaacctgc cgataactcg gggatagcct ttcgaaagaa agattaatac 180
ccgatagtat agtatttccg catggtttca ctattaaaga atttcggtta tcgatgggga 240
tgcgttccat tagatagttg gcggggtaac ggcccaccaa gtcaacgatg gataggggtt 300
ctgagaggaa ggtcccccac attggaactg agacacggtc caaactccta cgggaggcag 360
cagtgaggaa tattggtcaa tggacgagag tctgaaccag ccaagtagcg tgaaggatga 420
ctgccctatg ggttgtaaac ttcttttata cgggaataaa gtggagtatg catactcctt 480
tgtatgtacc gtatgaataa ggatcggcta actccgtgcc agcagccgcg gtaatacgga 540
ggatccgagc gttatccgga tttattgggt ttaaagggag cgtaggcggg tgcttaagtc 600
agttgtgaaa gtttgcggct caaccgtaaa attgcagttg atactgggta ccttgagtgc 660
agcataggta ggcggaattc gtggtgtagc ggtgaaatgc ttagatatca cgaagaactc 720
cgattgcgaa ggcagcttac tggactgtaa ctgacgctga tgctcgaaag tgtgggtatc 780
aaacaggatt agataccctg gtagtccaca cagtaaacga tgaatactcg ctgttggcga 840
tacacagtca gcggccaagc gaaagcatta agtattccac ctggggagta cgccggcaac 900
ggtgaaactc aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc 960
gatgatacgc gaggaacctt acccgggctt aaattgcagt ggaatgtagt ggaaacatta 1020
cagccttcgg gccgctgtga aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt 1080
cggcttaagt gccataacga gcgcaaccct tatctatagt tactatcagg tcatgctgag 1140
gactctatgg agactgccgt cgtaagatgt gaggaaggtg gggatgacgt caaatcagca 1200
cggcccttac gtccggggct acacacgtgt tacaatgggg ggtacagaag gcagctacct 1260
ggcgacagga tgctaatccc taaaacctct ctcagttcgg attggagtct gcaacccgac 1320
tccatgaagc tggattcgct agtaatcgcg catcagccac ggcgcggtga atacgttccc 1380
gggccttgta cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtacgtaacc 1440
gcaaggagcg tcctagggta aaactggtga ttggggctaa gtcgtaacaa ggtagccgta 1500
ccggaaggtg cggctggaac acctcctttc t 1531
<210> 12
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_eggerthii
<400> 12
tacaatgaag agtttgatcc tggctcagga tgaacgctag ctacaggctt aacacatgca 60
agtcgagggg cagcatgatt gaagcttgct tcaatcgatg gcgaccggcg cacgggtgag 120
taacacgtat ccaacctgcc gataactcgg ggatagcctt tcgaaagaaa gattaatacc 180
cgatagtata gtttttccgc atggtttcac tattaaagaa tttcggttat cgatggggat 240
gcgttccatt agatagttgg cggggtaacg gcccaccaag tcaacgatgg ataggggttc 300
tgagaggaag gtcccccaca ttggaactga gacacggtcc aaactcctac gggaggcagc 360
agtgaggaat attggtcaat ggacgagagt ctgaaccagc caagtagcgt gaaggatgac 420
tgccctatgg gttgtaaact tcttttatac gggaataaag tggagtatgc atactccttt 480
gtatgtaccg tatgaataag gatcggctaa ctccgtgcca gcagccgcgg taatacggag 540
gatccgagcg ttatccggat ttattgggtt taaagggagc gtaggcgggt gcttaagtca 600
gttgtgaaag tttgcggctc aaccgtaaaa ttgcagttga tactgggcgc cttgagtgca 660
gcataggtag gcggaattcg tggtgtagcg gtgaaatgct tagatatcac gaagaactcc 720
gattgcgaag gcagcttact ggactgtaac tgacgctgat gctcgaaagt gtgggtatca 780
aacaggatta gataccctgg tagtccacac agtaaacgat gaatactcgc tgttggcgat 840
acacagtcag cggccaagcg aaagcattaa gtattccacc tggggagtac gccggcaacg 900
gtgaaactca aaggaattga cgggggcccg cacaagcgga ggaacatgtg gtttaattcg 960
atgatacgcg aggaacctta cccgggctta aattgcagcg gaatgtagtg gaaacattac 1020
agccttcggg ccgctgtgaa ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc 1080
ggcttaagtg ccataacgag cgcaaccctt atctatagtt actatcaggt catgctgagg 1140
actctatgga gactgccgtc gtaagatgtg aggaaggtgg ggatgacgtc aaatcagcac 1200
ggcccttacg tccggggcta cacacgtgtt acaatggggg gtacagaagg cagctacctg 1260
gcgacaggat gctaatcccg aaaacctctc tcagttcgga ttggagtctg caacccgact 1320
ccatgaagct ggattcgcta gtaatcgcgc atcagccacg gcgcggtgaa tacgttcccg 1380
ggccttgtac acaccgcccg tcaagccatg aaagccgggg gtacctgaag tacgtaaccg 1440
caaggagcgt cctagggtaa aactggtgat tggggctaag tcgtaacaag gtagccgtac 1500
cggaaggtgc ggctggaaca cctcctt 1527
<210> 13
<211> 1458
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_faecis
<400> 13
gatgaacgct agctacaggc ttaacacatg caagtcgagg ggcagcattc cagtttgctt 60
gcaaactgga gatggcgacc ggcgcacggg tgagtaacac gtatccaacc tgccgataac 120
tcggggatag cctttcgaaa gaaagattaa tacccgatgg cataatagaa ccgcatggtt 180
tgattattaa agaatttcgg ttatcgatgg ggatgcgttc cattaggcag ttggtggggt 240
aacggcccac caaaccttcg atggataggg gttctgagag gaaggtcccc cacattggaa 300
ctgagacacg gtccaaactc ctacgggagg cagcagtgag gaatattggt caatggacga 360
gagtctgaac cagccaagta gcgtgaagga tgactgccct atgggttgta aacttctttt 420
atatgggaat aaagtgatcc acgtgtggat ttttgtatgt accatatgaa taaggatcgg 480
ctaactccgt gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg 540
ggtttaaagg gagcgtaggt ggacagttaa gtcagttgtg aaagtttgcg gctcaaccgt 600
aaaattgcag ttgatactgg ctgtcttgag tacagtagag gtgggcggaa ttcgtggtgt 660
agcggtgaaa tgcttagata tcacgaagaa ctccgattgc gaaggcagct cactggactg 720
caactgacac tgatgctcga aagtgtgggt atcaaacagg attagatacc ctggtagtcc 780
acacagtaaa cgatgaatac tcgctgtttg cgatatacag taagcggcca agcgaaagca 840
ttaagtattc cacctgggga gtacgccggc aacggtgaaa ctcaaaggaa ttgacggggg 900
cccgcacaag cggaggaaca tgtggtttaa ttcgatgata cgcgaggaac cttacccggg 960
cttaaattgc atttgaatat attggaaaca gtatagtcgt aagrcaaatg tgaaggtgct 1020
gcatggttgt cgtcagctcg tgccgtgagg tgtcggctta agtgccataa cgagcgcaac 1080
ccttatctty agttactaac aggtcatgct gaggactctg gagagactgc cgtcgtaaga 1140
tgtgaggaag gtggggatga cgtcaaatca gcacggccct tacgtccggg gctacacacg 1200
tgttacaatg gggggtacag aaggycgcta cctggtgaca ggatgctaat cccaaaagcc 1260
tctctcagtt cggatcgaag tctgcaaccc gacttcgtga agctggattc gctagtaatc 1320
gcgcatcagc catggcgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcaagc 1380
catgaaagcc gggggtacct gaagtacgta accgcaagga gcgtcctagg gtaaaactgg 1440
taattggggc taagtcgt 1458
<210> 14
<211> 1323
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_finegoldii
<400> 14
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat aactcaggga tagcctttcg 120
aaagaaagat taatacctga tggctaaagt cggttatcga tggggatgcg ttccattagt 180
ttgttggcgg ggtaacggcc caccaagaca gcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgggagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggt ggattgttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg cagtcttgag tacagtagag gtgggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct cactggactg actgacactg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg taagcggcca agcgaaagcg ttaagtattc cacctgggga 780
gtacgccggc acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat 840
gtggtttaat tcgatgatac gcgaggaacc ttacccgggc ttaaattgtg aaggtgctgc 900
atggttgtcg tcagctcgtg ccgtgaggtg tcggcttaag tgccataacg agcgcaaccc 960
ttatcttcag ttactaacag ctgaggactc tggagagact gccgtcgtaa gatggaggaa 1020
ggtggggatg acgtcaaatc agcacggccc ttacgtccgg ggctacacac gtgttacaat 1080
ggggggcaga aggcagctac ctggcgacag gatgccaatc ccgcctctct cagttcggac 1140
gaagtctgca acccgacttc ggaagctgga ttcgctagta atcgcgcatc agccatggcg 1200
cggtgaatac gttcccgggc cttgtacaca ccgcccgtca agccatgaaa gccgggggta 1260
cctgaagtac gtagcgtcct agggtaaaac tggtaattgg ggctaagtcg taacaaggta 1320
acc 1323
<210> 15
<211> 1485
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_finegoldii
<400> 15
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcattt tagtttgctt gcaaactaaa gatggcgacc ggcgcacggg tgagtaacac 120
gtatccaacc tgccgataac tcagggatag cctttcgaaa gaaagattaa taccggatgg 180
cataggattg tcgcatgatg atcctattaa agaatttcgg ttatcgatgg ggatgcgttc 240
cattaggcag ttggtgaggt aacggctcac caaaccttcg atggataggg gttctgagag 300
gaaggtcccc cacattggaa ctgagacacg gtccaaactc ctacgggagg cagcagtgag 360
gaatattggt caatggacgg gagtctgaac cagccaagta gcgtgaagga tgactgccct 420
atgggttgta aacttctttt atacgggaat aaagtgatcc acgtgtggat ttttgtatgt 480
accgtatgaa taaggatcgg ctaactccgt gccagcagcc gcggtaatac ggaggatccg 540
agcgttatcc ggatttattg ggtttaaagg gagcgtaggt ggattgttaa gtcagttgtg 600
aaagtttgcg gctcaaccgt aaaattgcag ttgatactgg cagtcttgag tacagtagag 660
gtgggcggaa ttcgtggtgt agcggtgaaa tgcttagata tcacgaagaa ctccgattgc 720
gaaggcagct cactggactg caactgacac tgatgctcga aagtgtgggt atcaaacagg 780
attagatacc ctggtagtcc acacagtaaa cgatgaatac tcgctgtttg cgatatacgg 840
taagcggcca agcgaaagcg ttaagtattc cacctgggga gtacgccggc aacggtgaaa 900
ctcaaaggaa ttgacggggg cccgcacaag cggaggaaca tgtggtttaa ttcgatgata 960
cgcgaggaac cttacccggg cttaaattac atttgaataa tctggaaaca ggttagccgt 1020
aaggcaaatg tgaaggtgct gcatggttgt cgtcagctcg tgccgtgagg tgtcggctta 1080
agtgccataa cgagcgcaac ccttatcttc agttactaac aggtcatgct gaggactctg 1140
gagagactgc cgtcgtaaga tgtgaggaag gtggggatga cgtcaaatca gcacggccct 1200
tacgtccggg gctacacacg tgttacaatg gggggtacag aaggcagcta cctggtgaca 1260
ggatgctaat cccaaaaacc tctctcagtt cggatcgaag tctgcaaccc gacttcgtga 1320
agctggattc gctagtaatc gcgcatcagc catggcgcgg tgaatacgtt cccgggcctt 1380
gtacacaccg cccgtcaagc catgaaagcc gggggtacct gaagtacgtt acccagagcg 1440
ttctaaggta aaatggtatt ggggctaagt cgtaacaagg taacc 1485
<210> 16
<211> 1322
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_finegoldii
<400> 16
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat aactcaggga tagcctttcg 120
aaagaaagat taataccgga tggctaaagt cggttatcga tggggatgcg ttccattagg 180
cagttggtga ggtaacggct caccaaacct tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgggagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggt ggattgttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg cagtcttgag tacagtagag gtgggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct cactggactg actgacactg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg taagcggcca agcgaaagcg ttaagtattc cacctgggga 780
gtacgccggc acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat 840
gtggtttaat tcgatgatac gcgaggaacc ttacccgggc ttaaattatg aagtgctgca 900
tggttgtcgt cagctcgtgc cgtgaggtgt cggcttaagt gccataacga gcgcaaccct 960
tatcttcagt tactaacagc tgaggactct ggagagactg ccgtcgtaag atggaggaag 1020
gtggggatga cgtcaaatca gcacggccct tacgtccggg gctacacacg tgttacaatg 1080
gggggcagaa ggcagctacc tggtgacagg atgctaatcc cacctctctc agttcggacg 1140
aagtctgcaa cccgacttcg gaagctggat tcgctagtaa tcgcgcatca gccatggcgc 1200
ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcaa gccatgaaag ccgggggtac 1260
ctgaagtacg tagcgtccta gggtaaaact ggtaattggg gctaagtcgt aacaaggtaa 1320
cc 1322
<210> 17
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_fluxus
<400> 17
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttt tatagcaata taaaagatgg cgaccggcgc acgggtgagt 120
aacacgtatc caacctgccg ataactcggg gataaccctt cgaaagaagg cctaataccc 180
gatggcatat cccttccgcc tggttgggat attaaagaac ttcggttatc gatggggatg 240
cgttccatta gcttgttggc ggggtaacgg cccaccaagg cttcgatgga taggggttct 300
gagaggaagg tcccccacat tggaactgag acacggtcca aactcctacg ggaggcagca 360
gtgaggaata ttggtcaatg gacgagagtc tgaaccagcc aagtagcgtg aaggatgaag 420
gtcctatgga ttgtaaactt cttttatacg ggaataaagt gcagtatgca tactgttttg 480
tatgtaccgt atgaataagg atcggctaac tccgtgccag cagccgcggt aatacggagg 540
atccgagcgt tatccggatt tattgggttt aaagggagcg taggcggatg cttaagtcag 600
ttgtgaaagt ttgcggctca accgtaaaat tgcagttgat actgggcgtc ttgagtacag 660
tagaggcagg cggaattcgt ggtgtagcgg tgaaatgctt agatatcacg aagaactccg 720
attgcgaagg cagcctgctg gactgtcact gacgctgatg ctcgaaagtg tgggtatcaa 780
acaggattag ataccctggt agtccacaca gtaaacgatg aatactcgct gttggcgata 840
cacagtcagc ggccaagcga aagcgttaag tattccacct ggggagtacg ccggcaacgg 900
tgaaactcaa aggaattgac gggggcccgc acaagcggag gaacatgtgg tttaattcga 960
tgatacgcga ggaaccttac ccgggcttga attgcatatg agttatccgg agacggataa 1020
gccgcaaggc atatgtgaag gtgctgcatg gttgtcgtca gctcgtgccg tgaggtgtcg 1080
gcttaagtgc cataacgagc gcaaccctta tcgatagtta ccatcaggtc atgctgggga 1140
ctctgtcgag actgccgtcg taagatgcga ggaaggtggg gatgacgtca aatcagcacg 1200
gcccttacgt ccggggccac acacgtgtta caatgggggg tacagaaggc cgctacacag 1260
cgatgtgatg ccaatcccca aaacccctct cagttcggat tggagtctgc aacccgactc 1320
catgaagctg gattcgctag taatcgcgca tcagccacgg cgcggtgaat acgttcccgg 1380
gccttgtaca caccgcccgt caagccatga aagccggggg tacctgaagt gcgtaaccgc 1440
gaggagcgcc ctagggtaaa actggtgatt ggggctaagt cgtaacaagg tagccgtacc 1500
ggaaggtgcg gctggaacac ctcctttct 1529
<210> 18
<211> 1486
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_helcogenes
<400> 18
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcattg tcatagcaat atgacagatg gcgaccggcg cacgggtgag taacacgtat 120
ccaacctgcc ttccactcgg gaatagcctt tcgaaagaaa gattaatgcc cgatggcact 180
gaaagaggtc atcctttttc agttaaagaa tttcggtgga agatggggat gcgttccatt 240
agcttgttgg cggggtaacg gcccaccaag gcatcgatgg ataggggttc tgagaggaag 300
gtcccccaca ttggaactga gacacggtcc aaactcctac gggaggcagc agtgaggaat 360
attggtcaat gggcgggagc ctgaaccagc caagtagcgt gaaggatgac tgccctatgg 420
gttgtaaact tcttttataa gggaataaaa cgggccacgt gtggcctttt gcatgtacct 480
tatgaataag gatcggctaa ctccgtgcca gcagccgcgg taatacggag gatccgagcg 540
ttatccggat ttattgggtt taaagggagc gcagacgggg tcttaagtca gttgtgaaag 600
tttgcggctc aaccgtaaaa ttgcagttga tactggggct cttgagtgca gtataggcag 660
gcggaattcg tggtgtagcg gtgaaatgct tagatatcac gaagaactcc gattgcgaag 720
gcagcctgct ggactgtaac tgacgttcat gctcgaaagt gcgggtatca aacaggatta 780
gataccctgg tagtccgcac agtaaacgat gaatactcgc tgttggcgat acacagtcag 840
cggccaagcg aaagcgttaa gtattccacc tggggagtac gccggcaacg gtgaaactca 900
aaggaattga cgggggcccg cacaagcgga ggaacatgtg gtttaattcg atgatacgcg 960
aggaacctta cccgggcttg aattgctaat gaatatggcg gaaacgtcat agccgcaagg 1020
ccttagtgaa ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc ggcttaagtg 1080
ccataacgag cgcaaccctt atctatagtt accatcaggc aatgctgggg actctatgga 1140
gactgccgtc gtaagatgtg aggaaggttg ggatgacgtc aaatcagcac ggcccttacg 1200
tccggggcta cacacgtgtt acaatggggg gtacagaagg cagctacaca gcgatgtgat 1260
gctaatccca aaaacctctc tcagttcgga ctggagtctg caacccgact ccacgaagct 1320
ggattcgcta gtaatcgcgc atcagccacg gcgcggtgaa tacgttcccg ggccttgtac 1380
acaccgcccg tcaagccatg aaagccgggg gtacctgaag tgcgtaaccg cgaggagcgc 1440
cctagggtaa aactggtgat tggggctaag tcgtaacaag gtaacc 1486
<210> 19
<211> 1513
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_helcogenes
<400> 19
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcattg tcatagcaat atgacagatg gcgaccggcg cacgggtgag taacacgtat 120
ccaacctgcc ttccactcgg gaatagcctt tcgaaagaaa gattaatgcc cgatggcact 180
gaaagaggtc atcctttttc agttaaagaa tttcggtgga agatggggat gcgttccatt 240
agcttgttgg cggggtaacg gcccaccaag gcatcgatgg ataggggttc tgagaggaag 300
gtcccccaca ttggaactga gacacggtcc aaactcctac gggaggcagc agtgaggaat 360
attggtcaat gggcgggagc ctgaaccagc caagtagcgt gaaggatgac tgccctatgg 420
gttgtaaact tcttttataa gggaataaaa cgggccacgt gtggcctttt gcatgtacct 480
tatgaataag gatcggctaa ctccgtgcca gcagccgcgg taatacggag gatccgagcg 540
ttatccggat ttattgggtt taaagggagc gcagacgggg tcttaagtca gttgtgaaag 600
tttgcggctc aaccgtaaaa ttgcagttga tactggggct cttgagtgca gtataggcag 660
gcggaattcg tggtgtagcg gtgaaatgct tagatatcac gaagaactcc gattgcgaag 720
gcagcctgct ggactgtaac tgacgttcat gctcgaaagt gcgggtatca aacaggatta 780
gataccctgg tagtccgcac agtaaacgat gaatactcgc tgttggcgat acacagtcag 840
cggccaagcg aaagcgttaa gtattccacc tggggagtac gccggcaacg gtgaaactca 900
aaggaattga cgggggcccg cacaagcgga ggaacatgtg gtttaattcg atgatacgcg 960
aggaacctta cccgggcttg aattgctaat gaatatggcg gaaacgtcat agccgcaagg 1020
cattagtgaa ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc ggcttaagtg 1080
ccataacgag cgcaaccctt atctatagtt accatcaggc aatgctgggg actctatgga 1140
gactgccgtc gtaagatgtg aggaaggttg ggatgacgtc aaatcagcac ggcccttacg 1200
tccggggcta cacacgtgtt acaatggggg gtacagaagg cagctacaca gcgatgtgat 1260
gctaatccca aaaacctctc tcagttcgga ctggagtctg caacccgact ccacgaagct 1320
ggattcgcta gtaatcgcgc atcagccacg gcgcggtgaa tacgttcccg ggccttgtac 1380
acaccgcccg tcaagccatg aaagccgggg gtacctgaag tgcgtaaccg cgaggagcgc 1440
cctagggtaa aactggtgat tggggctaag tcgtaacaag gtagccgtac cggaaggtgc 1500
ggctggaaca cct 1513
<210> 20
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_intestinalis
<400> 20
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat tattccggga tagcctttcg 120
aaagaaagat taatactgga tagctaaagt cgataatcga tggggatgcg ttccattagt 180
ttgttggcgg ggtaacggcc caccaagaca tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatatggga atatgtatgt accatacgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccr agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggattattaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg tagtcttgag tgcagcagag gtaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tactggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agcaagcggc caagcgaaag cattaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttaaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatctt tagttactaa cagctgagga ctctagagag actgccgtcg taagatggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc cggggctaca cacgtgttac 1080
aatggggggc agaaggcagc tacacagcga tgtgatgcta atcccacctc tctcagttcg 1140
gatggagtct gcaacccgac tccagaagct ggattcgcta gtaatcgcgc atcagccacg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg aaagccgggg 1260
gtacctgaag tacgtagcgt cctagggtaa aactggtaat tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 21
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_intestinalis
<400> 21
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatgac ctagcaatag gttgatggcg accggcgcac gggtgagtaa 120
cacgtatcca acctgccgat tattccggga tagcctttcg aaagaaagat taatactgga 180
tagcataacg agaaggcatc ttcttgttat taaagaattt cgataatcga tggggatgcg 240
ttccattagt ttgttggcgg ggtaacggcc caccaagaca tcgatggata ggggttctga 300
gaggaaggtc ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt 360
gaggaatatt ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc 420
cctatgggtt gtaaacttct tttatatggg aataaagtga gccacgtgtg gctttttgta 480
tgtaccatac gaataaggat cggctaactc cgtgccagca gccgcggtaa tacggaggat 540
ccgagcgtta tccggattta ttgggtttaa agggagcgta ggcggattat taagtcagtt 600
gtgaaagttt gcggctcaac cgtaaaattg cagttgatac tggtagtctt gagtgcagca 660
gaggtaggcg gaattcgtgg tgtagcggtg aaatgcttag atatcacgaa gaactccgat 720
tgcgaaggca gcttactgga ctgtaactga cgctgatgct cgaaagtgtg ggtatcaaac 780
aggattagat accctggtag tccacacagt aaacgatgaa tactcgctgt ttgcgatata 840
cagcaagcgg ccaagcgaaa gcattaagta ttccacctgg ggagtacgcc ggcaacggtg 900
aaactcaaag gaattgacgg gggcccgcac aagcggagga acatgtggtt taattcgatg 960
atacgcgagg aaccttaccc gggcttaaat tgcaactgac ggatttggaa acagatcttc 1020
cttcgggcag ttgtgaaggt gctgcatggt tgtcgtcagc tcgtgccgtg aggtgtcggc 1080
ttaagtgcca taacgagcgc aacccttatc tttagttact aacaggtcat gctgaggact 1140
ctagagagac tgccgtcgta agatgtgagg aaggtgggga tgacgtcaaa tcagcacggc 1200
ccttacgtcc ggggctacac acgtgttaca atggggggta cagaaggcag ctacacagcg 1260
atgtgatgct aatcccaaaa gcctctctca gttcggattg gagtctgcaa cccgactcca 1320
tgaagctgga ttcgctagta atcgcgcatc agccacggcg cggtgaatac gttcccgggc 1380
cttgtacaca ccgcccgtca agccatgaaa gccgggggta cctgaagtac gtaaccgcaa 1440
ggagcgtcct agggtaaaac tggtaattgg ggctaagtcg taacaaggta gccgtaccgg 1500
aaggtgcggc tggaacacct cctttct 1527
<210> 22
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_intestinalis
<400> 22
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat tattccggga tagcctttcg 120
aaagaaagat taatactgga tagctaaagt cgataatcga tggggatgcg ttccattagt 180
ttgttggcgg ggtaacggcc caccaagaca tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatatggga atatgtatgt accatacgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggattattaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg tagtcttgag tgcagcagag gtaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tactggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agcaagcggc caagcgaaag cattaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttaaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatctt tagttactaa cagctgagga ctctagagag actgccgtcg taagatggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc cggggctaca cacgtgttac 1080
aatggggggc agaaggcagc tacacagcga tgtgatgcta atcccacctc tctcagttcg 1140
gatggagtct gcaacccgac tccagaagct ggattcgcta gtaatcgcgc atcagccacg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg aaagccgggg 1260
gtacctgaag tacgtagcgt cctagggtaa aactggtaat tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 23
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_ovatus
<400> 23
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttt agtttgcttg caaactgaag atggcgaccg gcgcacgggt 120
gagtaacacg tatccaacct gccgataact ccgggatagc ctttcgaaag aaagattaat 180
accggatggc atacgaatat cgcatgatat ttttattaaa gaatttcggt tatcgatggg 240
gatgcgttcc attagtttgt tggcggggta acggcccacc aagactacga tggatagggg 300
ttctgagagg aaggtccccc acattggaac tgagacacgg tccaaactcc tacgggaggc 360
agcagtgagg aatattggtc aatgggcgag agcctgaacc agccaagtag cgtgaaggat 420
gaaggctcta tgggtcgtaa acttctttta tatgggaata aagttttcca cgtgtggaat 480
tttgtatgta ccatatgaat aaggatcggc taactccgtg ccagcagccg cggtaatacg 540
gaggatccga gcgttatccg gatttattgg gtttaaaggg agcgtaggtg gattgttaag 600
tcagttgtga aagtttgcgg ctcaaccgta aaattgcagt tgaaactggc agtcttgagt 660
acagtagagg tgggcggaat tcgtggtgta gcggtgaaat gcttagatat cacgaagaac 720
tccgattgcg aaggcagctc actagactgt tactgacact gatgctcgaa agtgtgggta 780
tcaaacagga ttagataccc tggtagtcca cacagtaaac gatgaatact cgctgtttgc 840
gatatacagt aagcggccaa gcgaaagcat taagtattcc acctggggag tacgccggca 900
acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat gtggtttaat 960
tcgatgatac gcgaggaacc ttacccgggc ttaaattgca acagaatata ttggaaacag 1020
tatagccgta aggctgttgt gaaggtgctg catggttgtc gtcagctcgt gccgtgaggt 1080
gtcggcttaa gtgccataac gagcgcaacc cttatcttta gttactaaca ggttatgctg 1140
aggactctag agagactgcc gtcgtaagat gtgaggaagg tggggatgac gtcaaatcag 1200
cacggccctt acgtccgggg ctacacacgt gttacaatgg ggggtacaga aggccgctac 1260
ctggtgacag gatgctaatc ccaaaaacct ctctcagttc ggatcgaagt ctgcaacccg 1320
acttcgtgaa gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc 1380
ccgggccttg tacacaccgc ccgtcaagcc atgaaagccg ggggtacctg aagtacgtaa 1440
ccgcaaggag cgtcctaggg taaaactggt aattggggct aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga acacctcctt tct 1533
<210> 24
<211> 1392
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_ovatus
<400> 24
tttagtttgc ttgcaaactg aagaatggcg accgcgcgca cgggtgagta acacgtatcc 60
aacctgccga taactccggg atagcctttc gaaagaaaga ttaataccgg atggcatact 120
aatatcgcat gatattttta ttaaagaatt tcggttatcg atggggatgc gttccattag 180
tttgttggcg gggtaacggc ccaccaagac aacgatggat aggggttctg agaggaaggt 240
cccccacatt ggaactgaga cacggtccaa actcctacgg gaggcagcag tgaggaatat 300
tggtcaatgg gcgagagcct gaaccagcca agtagcgtga aggatgactg ctctatgggt 360
cgtaaacttc ttttatatgg gaataaagta ttccacgtgt ggaattttgt atgtaccata 420
tgaataagga tcggctaact ccgtgccagc agccgcggta atacggagga tccgagcgtt 480
atccggattt attgggttta aagggagcgt aggtggattg ttaagtcagt tgtgaaagtt 540
tgcggctcaa ccgtaaaatt gcagttgaaa ctggcagtct tgagtacagt agaggtgggc 600
ggaattcgtg gtgtagcggt gaaatgctta gatatcacga agaactccga ttgcgaaggc 660
agctcactag actgtcactg acactgatgc tcgaaagtgt gggtatcaaa caggattaga 720
taccctggta gtccacacag taaacgatga atactcgctg tttgcgatat acagtaagcg 780
gccaagcgaa agcattaagt attccacctg gggagtacgc cggcaacggt gaaactcaaa 840
ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat gatacgcgag 900
gaaccttacc cgggcttaaa ttgcaacaga atattttgga aacagtatag ccgcaaggct 960
gttgtgaagg tgctgcatgg ttgtcgtcag ctcgtgccgt gaggtgtcgg cttaagtgcc 1020
ataacgagcg caacccttat ctttagttac taacaggtca tgctgaggac tctagagaga 1080
ctgccgtcgt aagatgtgag gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc 1140
cggggctaca cacgtgttac aatggggggt acagaaggca gctacctggc gacaggatgc 1200
taatcccaaa aacctctctc agttcggatc gaagtctgca acccgacttc gtgaagctgg 1260
attcgctagt aatcgcgcat cagccatggc gcggtgaata cgttcccggg ccttgtacac 1320
accgcccgtc aagccatgaa agcccggggg tacctgaagt acgtaaccgc aaggagcgtc 1380
ctagggtaaa ac 1392
<210> 25
<211> 1455
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_ovatus
<400> 25
gatcatggct caggatgaac gctagctaca ggcttaacac atacaagtcg tggggcagca 60
ttttatgttt gtttgcaaac tgaagatggc gaccggcgca cgggtgagta acacgtatcc 120
aacctgccga taactccgga atagcctttc gaaagaaaga ttaataccgg atagcatacg 180
atatcgcatg atatttttat taaagaattt cggttatcga tggggatgcg ttccattagt 240
ttgttggcgg ggtaacggcc caccaagact acgatggata ggggttctga gaggaaggtc 300
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 360
ggtcaatggg cgagagcctg aaccagccaa gtagcgtgaa ggatgaaggc tctatgggtc 420
gtaaacttct tttatatggg aataaagttt tccacgtgtg gaattttgta tgtaccatat 480
gaataaggat cggactactc cgtgccagca gccgcggtaa tacggaggat ccgagcgtta 540
tccggattta ttgggtttaa agggagcgta ggtggattgt taagtcagtt gtgaaagttt 600
gcggctcaac cgtaaaattg cagttgaaac tggcagtctt gagtacagta gaggtgggcg 660
gaattcgtgg tgtagcggtg aaatgcttag atatcacgaa gaactccgat tgcgaaggca 720
gctcactaga ctgttactga cactgatgct cgaaagtgtg ggtatcaaac aggattagat 780
accctggtag tccacacagt aaacgatgaa tactcgctgt ttgcgatata cagtaagcgg 840
ccaagcgaaa gcattaagta ttccacctgg ggagtacgcc ggcaacggtg aaactcaaag 900
gaattgacgg gggcccgcac aagcggagga acatgtggtt taattcgatg atacgcgaga 960
accttacccg ggcttaaatt gcaacagaat atattggaaa cagtatagcc gtaaggctgt 1020
tgtgaaggtg ctgcatggtt gtcgtcagct cgtgccgtga ggtgtcggct taagtgccat 1080
aacgagcgca acccttatct ttagttacta acaggttatg ctgaggactc tagagagact 1140
gccgtcgtaa gatgtgagga aggtggggat gacgtcaaat cagcacggcc cttacgtccg 1200
gggctacaca cgtgttacaa tggggggtac agaaggcagc tacctggtga catgatgcta 1260
atcccaaaaa cctctctcag ttcggatcga agtctgcaac ccgacttcgt gaagctggat 1320
tcgctagtaa tcgcgcatca gccatggcgc ggtgaatacg ttcccgggcc ttgtacacac 1380
cgcccgtcaa gccatgaaag ccgggggtac ctgaagtacg taaccgcaag gagcgtccta 1440
gggtaaaact ggtaa 1455
<210> 26
<211> 1287
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_ovatus
<400> 26
gatgaacgct agctacaggc ttgacacatg caagtcgagg gaccggcgca cgggtgagta 60
acacgtatcc aacctgccga taactccgga atagcctttc gaaagaaaga ttaataccgg 120
atagctaaag tcggttatcg atggggatgc gttccattag tttgttggcg gggtaacggc 180
ccaccaagac tacgatggat aggggttctg agaggaaggt cccccacatt ggaactgaga 240
cacggtccaa actcctacgg gaggcagcag tgaggaatat tggtcaatgg gcgagagcct 300
gaaccagcca agtagcgtga aggatgaagg cttatgggtc gtaaacttct tttatatggg 360
aatatgtatg taccatatga ataaggatcg gctaactccg tgccagcagc cgcggtaata 420
cggaggatcc gagcgttatc cggatttatt gggtttaaag ggagcgtagg tggattgtta 480
agtcagttgt gaaagtttgc ggctcaaccg taaaattgca gttgaaactg gcagtcttga 540
gtacagtaga ggtgggcgga attcgtggtg tagcggtgaa atgcttagat atcacgaaga 600
actccgattg cgaaggcagc tcactagact gactgacact gatgctcgaa agtgtgggta 660
tcaaacagga ttagataccc tggtagtcca cacagtaaac gatgaatact cgctgtttgc 720
gagtaagcgg ccaagcgaaa gcattaagta ttccacctgg ggagtacgcc ggcaacggtg 780
aaactcaaag gaattgacgg gggcccgcac aagcggagga acatgtggtt taattcgatg 840
atacgcgagg aaccttaccc gggcttaaat tgtgaaggtg ctgcatggtt gtcgtcagct 900
cgtgccgtga ggtgtcggct taagtgccat aacgagcgca acccttatct ttagttacta 960
acagctgagg actctagaga gactgccgtc gtaagatgga ggaaggtggg gatgacgtca 1020
aatcagcacg gcccttacgt ccggggctac acacgtgtta caatgggggg cagaaggcag 1080
ctacctggcg acaggatgct aatcccacct ctctcagttc ggacgaagtc tgcaacccga 1140
cttcggaagc tggattcgct agtaatcgcg catcagccat ggcgcggtga atacgttccc 1200
gggccttgta cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtacgtagcg 1260
tcctagggta aaactggtaa ttggggc 1287
<210> 27
<211> 1509
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_ovatus
<400> 27
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcattt tagtttgctt gcaaactaaa gatggcgacc ggcgcacggg tgagtaacac 120
gtatccaacc tgccgataac tcggggatag cctttcgaaa gaaagattaa tatccgatag 180
tatattaaaa ccgcatggtt ttactattaa agaatttcgg ttatcgatgg ggatgcgttc 240
cattagtttg ttggcggggt aacggcccac caagactacg atggataggg gttctgagag 300
gaaggtcccc cacattggaa ctgagacacg gtccaaactc ctacgggagg cagcagtgag 360
gaatattggt caatggacga gagtctgaac cagccaagta gcgtgaagga tgactgccct 420
atgggttgta aacttctttt atatgggaat aaagtattcc acgtgtggga ttttgtatgt 480
accatatgaa taaggatcgg ctaactccgt gccagcagcc gcggtaatac ggaggatccg 540
agcgttatcc ggatttattg ggtttaaagg gagcgtaggt ggattgttaa gtcagttgtg 600
aaagtttgcg gctcaaccgt aaaattgcag ttgaaactgg cagtcttgag tacagtagag 660
gtgggcggaa ttcgtggtgt agcggtgaaa tgcttagata tcacgaagaa ctccgattgc 720
gaaggcagct cactagactg caactgacac tgatgctcga aagtgtgggt atcaaacagg 780
attagatacc ctggtagtcc acacagtaaa cgatgaatac tcgctgtttg cgatatacag 840
taagcggcca agcgaaagca ttaagtattc cacctgggga gtacgccggc aacggtgaaa 900
ctcaaaggaa ttgacggggg cccgcacaag cggaggaaca tgtggtttaa ttcgatgata 960
cgcgaggaac cttacccggg cttaaattgc atttgaataa tctggaaaca ggttagccgc 1020
aaggcaaatg tgaaggtgct gcatggttgt cgtcagctcg tgccgtgagg tgtcggctta 1080
agtgccataa cgagcgcaac ccttatcttt agttactaac aggtcatgct gaggactcta 1140
gagagactgc cgtcgtaaga tgtgaggaag gtggggatga cgtcaaatca gcacggccct 1200
tacgtccggg gctacacacg tgttacaatg gggggtacag aaggcagcta cctggcgaca 1260
ggatgctaat cccaaaaacc tctctcagtt cggatcgaag tctgcaaccc gacttcgtga 1320
agctggattc gctagtaatc gcgcatcagc catggcgcgg tgaatacgtt cccgggcctt 1380
gtacacaccg cccgtcaagc catgaaagcc gggggtacct gaagtacgta accgcaagga 1440
gcgtcctagg gtaaaactgg taattggggc taagtcgtaa caaggtagcc gtaccggaag 1500
gtgcggctg 1509
<210> 28
<211> 1311
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_ovatus
<400> 28
gatcctggct caggatgaac gctagctaca ggcttaacac atgcaagtcg agggaccggc 60
gcacgggtga gtaacacgta tccaacctgc cgataactcc ggaatagcct ttcgaaagaa 120
agattaatac cggatagtta aagtcggtta tcgatgggga tgcgttccat tagtttgttg 180
gcggggtaac ggcccaccaa gcctacgatg gataggggtt ctgagaggaa ggtcccccac 240
attggaactg agacacggtc caaactccta cgggaggcag cagtgaggaa tattggtcaa 300
tgggcgagag cctgaaccag ccaagtagcg tgaaggatga aggcttatgg gtcgtaaact 360
tcttttatat gggaatatgt atgtaccata tgaataagga tcggctaact ccgtgccagc 420
agccgcggta atacggagga tccgagcgtt atccggattt attgggttta aagggagcgt 480
aggtggattg ttaagtcagt tgtgaaagtt tgcggctcaa ccgtaaaatt gcagttgaaa 540
ctggcagtct tgagtacagt agaggtgggc ggaattcgtg gtgtagcggt gaaatgctta 600
gatatcacga agaactccga ttgcgaaggc agctcactag actgactgac actgatgctc 660
gaaagtgtgg gtatcaaaca ggattagata ccctggtagt ccacacagta aacgatgaat 720
actcgctgtt tgcgagtaag cggccaagcg aaagcattaa gtattccacc tggggagtac 780
gccggcaacg gtgaaactca aaggaattga cgggggcccg cacaagcgga ggaacatgtg 840
gtttaattcg atgatacgcg aggaacctta cccgggctta aattgtgaag gtgctgcatg 900
gttgtcgtca gctcgtgccg tgaggtgtcg gcttaagtgc cataacgagc gcaaccctta 960
tctttagtta ctaacagctg aggactctag agagactgcc gtcgtaagat ggaggaaggt 1020
ggggatgacg tcaaatcatc acggccctta cgtccggggc tacacacgtg ttacaatggg 1080
gggcagaagg cggctacctg gtgacaggat gctaatccca cctctctcag ttcggacgaa 1140
gtctgcaacc cgacttcgga agctggattc gctagtaatc gcgcatcagc catggcgcgg 1200
tgaatacgtt cccgggcctt gtacacaccg cccgtcaagc catgaaagcc gggggtacct 1260
gaagtacgta gcgtcctagg taaaactggt aattggggct aagtcgtaac a 1311
<210> 29
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_1_1_30
<400> 29
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttc gctagcaata gtgaagatgg cgaccggcgc acgggtgagt 120
aacacgtatc caacctgccg ataactcggg gatagccttt cgaaagaaag attaatatcc 180
gatagtatat taaaaccgca tggttttact attaaagaat ttcggttatc gatggggatg 240
cgttccatta gtttgttggc ggggtaacgg cccaccaaga ctacgatgga taggggttct 300
gagaggaagg tcccccacat tggaactgag acacggtcca aactcctacg ggaggcagca 360
gtgaggaata ttggtcaatg gacgagagtc tgaaccagcc aagtagcgtg aaggatgact 420
gccctatggg ttgtaaactt cttttatatg ggaataaagt attccacgtg tgggattttg 480
tatgtaccat atgaataagg atcggctaac tccgtgccag cagccgcggt aatacggagg 540
atccgagcgt tatccggatt tattgggttt aaagggagcg taggtggatt gttaagtcag 600
ttgtgaaagt ttgcggctca accgtaaaat tgcagttgaa actggcagtc ttgagtacag 660
tagaggtggg cggaattcgt ggtgtagcgg tgaaatgctt agatatcacg aagaactccg 720
attgcgaagg cagctcacta gactgcaact gacactgatg ctcgaaagtg tgggtatcaa 780
acaggattag ataccctggt agtccacaca gtaaacgatg aatactcgct gtttgcgata 840
tacagtaagc ggccaagcga aagcattaag tattccacct ggggagtacg ccggcaacgg 900
tgaaactcaa aggaattgac gggggcccgc acaagcggag gaacatgtgg tttaattcga 960
tgatacgcga ggaaccttac ccgggcttaa attgcatttg aataatctgg aaacaggtta 1020
gccgcaaggc aaatgtgaag gtgctgcatg gttgtcgtca gctcgtgccg tgaggtgtcg 1080
gcttaagtgc cataacgagc gcaaccctta tctttagtta ctaacaggtt atgctgagga 1140
ctctagagag actgccgtcg taagatgtga ggaaggtggg gatgacgtca aatcagcacg 1200
gcccttacgt ccggggctac acacgtgtta caatgggggg tacagaaggc agctacctgg 1260
tgacaggatg ctaatcccaa aaacctctct cagttcggat cgaagtctgc aacccgactt 1320
cgtgaagctg gattcgctag taatcgcgca tcagccatgg cgcggtgaat acgttcccgg 1380
gccttgtaca caccgcccgt caagccatga aagccggggg tacctgaagt acgtaaccgc 1440
aaggagcgtc ctagggtaaa actggtaatt ggggctaagt cgtaacaagg tagccgtacc 1500
ggaaggtgcg gctggaacac ctcctttct 1529
<210> 30
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_20_3
<400> 30
acaacgaaga gtttgatcct ggctcaggat gaacgctagc gacaggctta acacatgcaa 60
gtcgaggggc agcacaggta gcaataccgg gtggcgaccg gcgcacgggt gagtaacgcg 120
tatgcaactt acctatcaga gggggataac ccggcgaaag tcggactaat accgcatgaa 180
gcaggggtcc ccgcatgggg atatttgcta aagattcatc gctgatagat aggcatgcgt 240
tccattaggc agttggcggg gtaacggccc accaaaccga cgatggatag gggttctgag 300
aggaaggtcc cccacattgg tactgagaca cggaccaaac tcctacggga ggcagcagtg 360
aggaatattg gtcaatgggc gtaagcctga accagccaag tcgcgtgagg gatgaaggtt 420
ctatggatcg taaacctctt ttataaggga ataaagtgcg ggacgtgtcc tgttttgtat 480
gtaccttatg aataaggatc ggctaactcc gtgccagcag ccgcggtaat acggaggatc 540
cgagcgttat ccggatttat tgggtttaaa gggtgcgtag gcggcctttt aagtcagcgg 600
tgaaagtctg tggctcaacc atagaattgc cgttgaaact ggggggcttg agtatgtttg 660
aggcaggcgg aatgcgtggt gtagcggtga aatgcttaga tatcacgcag aaccccgatt 720
gcgaaggcag cctgccaagc catgactgac gctgatgcac gaaagcgtgg ggatcaaaca 780
ggattagata ccctggtagt ccacgcagta aacgatgatc actagctgtt tgcgatacag 840
tgtaagcggc acagcgaaag cgttaagtga tccacctggg gagtacgccg gcaacggtga 900
aactcaaagg aattgacggg ggcccgcaca agcggaggaa catgtggttt aattcgatga 960
tacgcgagga accttacccg ggtttgaacg cattcggacc gaggtggaaa caccttttct 1020
agcaatagcc gtttgcgagg tgctgcatgg ttgtcgtcag ctcgtgccgt gaggtgtcgg 1080
cttaagtgcc ataacgagcg caacccttgc cactagttac taacaggtga tgctgaggac 1140
tctggtggga ctgccagcgt aagctgcgag gaaggcgggg atgacgtcaa atcagcacgg 1200
cccttacatc cggggcgaca cacgtgttac aatggcgtgg acaaagggag ccacctggcg 1260
acagggagcg aatccccaaa ccacgtctca gttcggatcg gagtctgcaa cccgactccg 1320
tgaagctgga ttcgctagta atcgcgcatc agccatggcg cggtgaatac gttcccgggc 1380
cttgtacaca ccgcccgtca agccatggga gccgggggta cctgaagtcc gtaaccgcga 1440
ggatcggcct agggtaaaac tggtgactgg ggctaagtcg taacaaggta gccgtaccgg 1500
aaggtgcggc tggaacacct cctttct 1527
<210> 31
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_2_1_22
<400> 31
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttt agtttgcttg caaactaaag atggcgaccg gcgcacgggt 120
gagtaacacg tatccaacct gccgataact cggggatagc ctttcgaaag aaagattaat 180
atccgatggt atattaaaac cgcatggttt tactattaaa gaatttcggt tatcgatggg 240
gatgcgttcc attagtttgt tggcggggta acggcccacc aagactacga tggatagggg 300
ttctgagagg aaggtccccc acattggaac tgagacacgg tccaaactcc tacgggaggc 360
agcagtgagg aatattggtc aatggacgag agtctgaacc agccaagtag cgtgaaggat 420
gactgcccta tgggttgtaa acttctttta tatgggaata aagtattcca cgtgtggaat 480
tttgtatgta ccatatgaat aaggatcggc taactccgtg ccagcagccg cggtaatacg 540
gaggatccga gcgttatccg gatttattgg gtttaaaggg agcgtaggtg gattgttaag 600
tcagttgtga aagtttgcgg ctcaaccgta aaattgcagt tgaaactggc agtcttgagt 660
acagtagagg tgggcggaat tcgtggtgta gcggtgaaat gcttagatat cacgaagaac 720
tccgattgcg aaggcagctc actagactgc aactgacact gatgctcgaa agtgtgggta 780
tcaaacagga ttagataccc tggtagtcca cacagtaaac gatgaatact cgctgtttgc 840
gatatacagt aagcggccaa gcgaaagcat taagtattcc acctggggag tacgccggca 900
acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat gtggtttaat 960
tcgatgatac gcgaggaacc ttacccgggc ttaaattgca tttgaataat ctggaaacag 1020
gttagccgca aggcaaatgt gaaggtgctg catggttgtc gtcagctcgt gccgtgaggt 1080
gtcggcttaa gtgccataac gagcgcaacc cttatcttta gttactaaca ggtcatgctg 1140
aggactctag agagactgcc gtcgtaagat gtgaggaagg tggggatgac gtcaaatcag 1200
cacggccctt acgtccgggg ctacacacgt gttacaatgg ggggtacaga aggcagctac 1260
ctggcgacag gatgctaatc ccaaaaacct ctctcagttc ggatcgaagt ctgcaacccg 1320
acttcgtgaa gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc 1380
ccgggccttg tacacaccgc ccgtcaagcc atgaaagccg ggggtacctg aagtacgtaa 1440
ccgcaaggag cgtcctaggg taaaactggt aattggggct aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga acacctcctt tct 1533
<210> 32
<211> 1525
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_2_2_4
<400> 32
tacaatgaag agtttgatcc tggctcagga tgaacgctag ctacaggctt aacacatgca 60
agtcgagggg cagcatttcg ctagcaatag tgaagatggc gaccggcgca cgggtgagta 120
acacgtatcc aacctgccga taactcgggg atagcctttc gaaagaaaga ttaatatccg 180
atagtatatt aaaaccgcat ggttttacta ttaaagaatt tcggttatcg atggggatgc 240
gttccattag tttgttggcg gggtaacggc ccaccaagac tacgatggat aggggttctg 300
agaggaaggt cccccacatt ggaactgaga cacggtccaa actcctacgg gaggcagcag 360
tgaggaatat tggtcaatgg acgagagtct gaaccagcca agtagcgtga aggatgactg 420
ccctatgggt tgtaaacttc ttttatatgg gaataaagta ttccacgtgt gggattttgt 480
atgtaccata tgaataagga tcggctaact ccgtgccagc agccgcggta atacggagga 540
tccgagcgtt atccggattt attgggttta aagggagcgt aggtggattg ttaagtcagt 600
tgtgaaagtt tgcggctcaa ccgtaaaatt gcagttgaaa ctgggagtct tgagtacagt 660
agaggtgggc ggaattcgtg gtgtagcggt gaaatgctta gatatcacga agaactccga 720
ttgcgaaggc agctcactag actgtcactg acactgatgc tcgaaagtgt gggtatcaaa 780
caggattaga taccctggta gtccacacag taaacgatga atactcgctg tttgcgatat 840
acagtaagcg gccaagcgaa agcattaagt attccacctg gggagtacgc cggcaacggt 900
gaaactcaaa ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat 960
gatacgcgag gaaccttacc cgggcttaaa ttgcaaatga ataatctgga aacaggttag 1020
ccgcaaggca tttgtgaagg tgctgcatgg ttgtcgtcag ctcgtgccgt gaggtgtcgg 1080
cttaagtgcc ataacgagcg caacccttat ctttagttac taacaggtta tgctgaggac 1140
tctagagaga ctgccgtcgt aagatgtgag gaaggtgggg atgacgtcaa atcagcacgg 1200
cccttacgtc cggggctaca cacgtgttac aatggggggt acagaaggca gctacctggt 1260
gacaggatgc taatcccaaa aacctctctc agttcggatc gaagtctgca acccgacttc 1320
gtgaagctgg attcgctagt aatcgcgcat cagccatggc gcggtgaata cgttcccggg 1380
ccttgtacac accgcccgtc aagccatgaa agccgggggt acctgaagta cgtaaccgca 1440
aggagcgtcc tagggtaaaa ctggtaattg gggctaagtc gtaacaaggt agccgtaccg 1500
gaaggtgcgg ctggaacacc tcctt 1525
<210> 33
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_3_1_19
<400> 33
acaacgaaga gtttgatcct ggctcaggat gaacgctagc gacaggctta acacatgcaa 60
gtcgaggggc agcacaggta gcaataccgg gtggcgaccg gcgcacgggt gagtaacgcg 120
tatgcaactt gcctatcaga gggggataac ccggcgaaag tcggactaat accgcatgaa 180
gcagggatcc cgcatgggaa tatttgctaa agattcatcg ctgatagata ggcatgcgtt 240
ccattaggca gttggcgggg taacggccca ccaaaccgac gatggatagg ggttctgaga 300
ggaaggtccc ccacattggt actgagacac ggaccaaact cctacgggag gcagcagtga 360
ggaatattgg tcaatggccg agaggctgaa ccagccaagt cgcgtgaggg atgaaggttc 420
tatggatcgt aaacctcttt tataagggaa taaagtgcgg gacgtgtccc gttttgtatg 480
taccttatga ataaggatcg gctaactccg tgccagcagc cgcggtaata cggaggatcc 540
gagcgttatc cggatttatt gggtttaaag ggtgcgtagg cggcctttta agtcagcggt 600
gaaagtctgt ggctcaacca tagaattgcc gttgaaactg gggggcttga gtatgtttga 660
ggcaggcgga atgcgtggtg tagcggtgaa atgcatagat atcacgcaga accccgattg 720
cgaaggcagc ctgccaagcc attactgacg ctgatgcacg aaagcgtggg gatcaaacag 780
gattagatac cctggtagtc cacgcagtaa acgatgatca ctagctgttt gcgatacact 840
gtaagcggca cagcgaaagc gttaagtgat ccacctgggg agtacgccgg caacggtgaa 900
actcaaagga attgacgggg gcccgcacaa gcggaggaac atgtggttta attcgatgat 960
acgcgaggaa ccttacccgg gtttgaacgc attcggaccg aggtggaaac accttttcta 1020
gcaatagccg tttgcgaggt gctgcatggt tgtcgtcagc tcgtgccgtg aggtgtcggc 1080
ttaagtgcca taacgagcgc aacccttgcc actagttact aacaggtaaa gctgaggact 1140
ctggtgggac tgccagcgta agctgcgagg aaggcgggga tgacgtcaaa tcagcacggc 1200
ccttacatcc ggggcgacac acgtgttaca atggcgtgga caaagggagg ccacctggcg 1260
acagggagcg aatccccaaa ccacgtctca gttcggatcg gagtctgcaa cccgactccg 1320
tgaagctgga ttcgctagta atcgcgcatc agccatggcg cggtgaatac gttcccgggc 1380
cttgtacaca ccgcccgtca agccatggga gccgggggta cctgaagtcc gtaaccgcga 1440
ggatcggcct agggtaaaac tggtgactgg ggctaagtcg taacaaggta gccgtaccgg 1500
aaggtgcggc tggaacacct cctttct 1527
<210> 34
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_3_1_23
<400> 34
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttt agtttgcttg caaactgaag atggcgaccg gcgcacgggt 120
gagtaacacg tatccaacct gccgataact ccggaatagc ctttcgaaag aaagattaat 180
accggatagt atacgaatat cgcatgatat ttttattaaa gaatttcggt tatcgatggg 240
gatgcgttcc attagtttgt tggcggggta acggcccacc aagactacga tggatagggg 300
ttctgagagg aaggtccccc acattggaac tgagacacgg tccaaactcc tacgggaggc 360
agcagtgagg aatattggtc aatgggcgag agcctgaacc agccaagtag cgtgaaggat 420
gaaggctcta tgggtcgtaa acttctttta tatgggaata aagtattcca cgtgtggaat 480
tttgtatgta ccatatgaat aaggatcggc taactccgtg ccagcagccg cggtaatacg 540
gaggatccga gcgttatccg gatttattgg gtttaaaggg agcgtaggtg gattgttaag 600
tcagttgtga aagtttgcgg ctcaaccgta aaattgcagt tgaaactggc agtcttgagt 660
acagtagagg tgggcggaat tcgtggtgta gcggtgaaat gcttagatat cacgaagaac 720
tccgattgcg aaggcagctc actagactgt tactgacact gatgctcgaa agtgtgggta 780
tcaaacagga ttagataccc tggtagtcca cacagtaaac gatgaatact cgctgtttgc 840
gatatacagt aagcggccaa gcgaaagcat taagtattcc acctggggag tacgccggca 900
acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat gtggtttaat 960
tcgatgatac gcgaggaacc ttacccgggc ttaaattgca acagaatata ttggaaacag 1020
tatagccgta aggctgttgt gaaggtgctg catggttgtc gtcagctcgt gccgtgaggt 1080
gtcggcttaa gtgccataac gagcgcaacc cttatcttta gttactaaca ggtgatgctg 1140
aggactctag agagactgcc gtcgtaagat gtgaggaagg tggggatgac gtcaaatcag 1200
cacggccctt acgtccgggg ctacacacgt gttacaatgg ggggtacaga aggcggctac 1260
ctggtgacag gatgctaatc ccaaaaacct ctctcagttc ggatcgaagt ctgcaacccg 1320
acttcgtgaa gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc 1380
ccgggccttg tacacaccgc ccgtcaagcc atgaaagccg ggggtacctg aagtacgtaa 1440
ccgcaaggag cgtcctaggg taaaactggt aattggggct aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga acacctcctt tct 1533
<210> 35
<211> 1446
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_3_2_5
<400> 35
acaacgaaga gtttgatcct ggctcaggat gaacgctagc gacaggctta acacatgcaa 60
gtcgaggggc agcacaggta gcaataccgg gtggcgaccg gcgcacgggt gagtaacgcg 120
tatgcaactt gcctatcaga gggggataac ccggcgaaag tcggactaat accgcatgaa 180
gcaggggccc cgcatgggga tatttgctaa agattcatcg ctgatagata ggcatgcgtt 240
ccattaggca gttggcgggg taacggccca ccaaaccgac gatggatagg ggttctgaga 300
ggaaggtccc ccacattggt actgagacac ggaccaaact cctacgggag gcagcagtga 360
ggaatattgg tcaatggccg agaggctgaa ccagccaagt cgcgtgaggg atgaaggttc 420
tatggatcgt aaacctcttt tataagggaa taaagtgcgg gacgtgtccc gttttgtatg 480
taccttatga ataaggatcg gctaactccg tgccagcagc cgcggtaata cggaggatcc 540
gagcgttatc cggatttatt gggtttaaag ggtgcgtagg cggcctttta agtcagcggt 600
gaaagtctgt ggctcaacca tagaattgcc gttgaaactg gggggcttga gtatgtttga 660
ggcaggcgga atgcgtggtg tagcggtgaa atgcatagat atcacgcaga accccgattg 720
cgaaggcagc ctgccaagcc atgactgacg ctgatgcacg aaagcgtggg gatcaaacag 780
gattagatac cctggtagtc cacgcagtaa acgatgatca ctagctgttt gcgatacact 840
gtaagcggca cagcgaaagc gttaagtgat ccacctgggg agtacgccgg caacggtgaa 900
actcaaagga attgacgggg gcccgcacaa gcggaggaac atgtggttta attcgatgat 960
acgcgaggaa ccttacccgg gtttgaacgc attcggaccg aggtggaaac accttttcta 1020
gcaatagccg tttgcgaggt gctgcatggt tgtcgtcagc tcgtgccgtg aggtgtcggc 1080
ttaagtgcca taacgagcgc aacccttgcc actagttact aacaggtgat gctgaggact 1140
ctggtgggac tgccagcgta agctgcgagg aaggcgggga tgacgtcaaa tcagcacggc 1200
ccttacatcc ggggcgacac acgtgttaca atggcgtgga caaagggagg ccacctggcg 1260
acagggagcg aatccccaaa ccacgtctca gttcggatcg gagtctgcaa cccgactccg 1320
tgaagctgga ttcgctagta atcgcgcatc agccatggcg cggtgaatac gttcccgggc 1380
cttgtacaca ccgcccgtca agccatggga gccgggggta cctgaagtcc gtaaccgcga 1440
ggatcg 1446
<210> 36
<211> 1531
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_4_1_36
<400> 36
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatgaa cttagcttgc taagtttgat ggcgaccggc gcacgggtga 120
gtaacacgta tccaacctgc cgatgactcg gggatagcct ttcgaaagaa agattaatac 180
ccgatggcat agttcttccg catggtggaa ctattaaaga atttcggtca tcgatgggga 240
tgcgttccat taggttgttg gcggggtaac ggcccaccaa gccttcgatg gataggggtt 300
ctgagaggaa ggtcccccac attggaactg agacacggtc caaactccta cgggaggcag 360
cagtgaggaa tattggtcaa tggacgagag tctgaaccag ccaagtagcg tgaaggatga 420
ctgccctatg ggttgtaaac ttcttttata cgggaataaa gtgaggcacg tgtgcctttt 480
tgtatgtacc gtatgaataa ggatcggcta actccgtgcc agcagccgcg gtaatacgga 540
ggatccgagc gttatccgga tttattgggt ttaaagggag cgtaggcgga cgcttaagtc 600
agttgtgaaa gtttgcggct caaccgtaaa attgcagttg atactgggtg tcttgagtac 660
agtagaggca ggcggaattc gtggtgtagc ggtgaaatgc ttagatatca cgaagaactc 720
cgattgcgaa ggcagcttgc tggactgtaa ctgacgctga tgctcgaaag tgtgggtatc 780
aaacaggatt agataccctg gtagtccaca cagtaaacga tgaatactcg ctgtttgcga 840
tatacagtaa gcggccaagc gaaagcgtta agtattccac ctggggagta cgccggcaac 900
ggtgaaactc aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc 960
gatgatacgc gaggaacctt acccgggctt gaattgcaac tgaatgatgt ggagacatgt 1020
cagccgcaag gcagttgtga aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt 1080
cggcttaagt gccataacga gcgcaaccct tatcgatagt taccatcagg ttatgctggg 1140
gactctgtcg agactgccgt cgtaagatgt gaggaaggtg gggatgacgt caaatcagca 1200
cggcccttac gtccggggct acacacgtgt tacaatgggg ggtacagaag gcagctacac 1260
ggcgacgtga tgctaatccc taaagcctct ctcagttcgg attggagtct gcaacccgac 1320
tccatgaagc tggattcgct agtaatcgcg catcagccac ggcgcggtga atacgttccc 1380
gggccttgta cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtgcgtaacc 1440
gcaaggagcg ccctagggta aaactggtga ttggggctaa gtcgtaacaa ggtagccgta 1500
ccggaaggtg cggctggaac acctcctttc t 1531
<210> 37
<211> 1489
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_AR20
<400> 37
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
gcagcatgaa cttagcttgc taagtttgat ggcgaccggc gcacgggtga gtaacacgta 120
tccaacctgc cgatgactcg gggatagcct ttcgaaagaa agattaatac ccgatggcat 180
agttcttccg catggtagaa ctattaaaga atttcggtca tcgatgggga tgcgttccat 240
taggttgttg gcggggtaac ggcccaccaa gccttcgatg gataggggtt ctgagaggaa 300
ggtcccccac attggaactg agacacggtc caaactccta cgggaggcag cagtgaggaa 360
tattggtcaa tggacgagag tctgaaccag ccaagtagcg tgaaggatga ctgccctatg 420
ggttgtaaac ttcttttata cgggaataaa gtgaggcacg cgtgcctttt tgtatgtacc 480
gtatgaataa ggatcggcta actccgtgcc agcagccgcg gtaatacgga ggatccgagc 540
gttatccgga tttattgggt ttaaagggag cgtaggcgga cgcttaagtc agttgtgaaa 600
gtttgcggct caaccgtaaa attgcagttg atactgggtg tcttgagtac agtagaggca 660
ggcggaattc gtggtgtagc ggtgaaatgc ttagatatca cgaagaactc cgattgcgaa 720
ggcagcctgc tggactgtaa ctgacgctga tgctcgaaag tgtgggtatc aaacaggatt 780
agataccctg gtagtccaca cagtaaacga tgaatactcg ctgtttgcga tatacagtaa 840
gcggccaagc gaaagcgtta agtattccac ctggggagta cgccggcaac ggtgaaactc 900
aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc gatgatacgc 960
gaggaacctt acccgggctt gaattgcaac tgaatgatgt ggagacatgt cagccgcaag 1020
gcagttgtga aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt cggcttaagt 1080
gccataacga gcgcaaccct tatcgatagt taccatcagg ttatgctggg gactctgtcg 1140
agactgccgt cgtaagatgt gaggaaggtg gggatgacgt caaatcagca cggcccttac 1200
gtccggggct acacacgtgt tacaatgggg ggtacagaag gcagctacac ggcgacgtga 1260
tgctaatccc taaagcctct ctcagttcgg attggagtct gcaacccgac tccatgaagc 1320
tggattcgct agtaatcgcg catcagccac ggcgcggtga atacgttccc gggccttgta 1380
cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtgcgtaacc gcaaggagcg 1440
ccctagggta aaactggtga ttggggctaa gtcgtaacaa ggtagccgt 1489
<210> 38
<211> 1517
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_D1
<400> 38
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcattt tagtttgctt gcaaactaaa gatggcgacc ggcgcacggg tgagtaacac 120
gtatccaacc tgccgataac tcggggatag cctttcgaaa gaaagattaa tatccgatgg 180
tatattaaaa ccgcatggtt ttactattaa agaatttcgg ttatcgatgg ggatgcgttc 240
cattagtttg ttggcggggt aacggcccac caagactacg atggataggg gttctgagag 300
gaaggtcccc cacattggaa ctgagacacg gtccaaactc ctacgggagg cagcagtgag 360
gaatattggt caatggacga gagtctgaac cagccaagta gcgtgaagga tgactgccct 420
atgggttgta aacttctttt atatgggaat aaagtattcc acgtgtggaa ttttgtatgt 480
accatatgaa taaggatcgg ctaactccgt gccagcagcc gcggtaatac ggaggatccg 540
agcgttatcc ggatttattg ggtttaaagg gagcgtaggt ggattgttaa gtcagttgtg 600
aaagtttgcg gctcaaccgt aaaattgcag ttgaaactgg cagtcttgag tacagtagag 660
gtgggcggaa ttcgtggtgt agcggtgaaa tgcttagata tcacgaagaa ctccgattgc 720
gaaggcagct cactagactg caactgacac tgatgctcga aagtgtgggt atcaaacagg 780
attagatacc ctggtagtcc acacagtaaa cgatgaatac tcgctgtttg cgatatacag 840
taagcggcca agcgaaagca ttaagtattc cacctgggga gtacgccggc aacggtgaaa 900
ctcaaaggaa ttgacggggg cccgcacaag cggaggaaca tgtggtttaa ttcgatgata 960
cgcgaggaac cttacccggg cttaaattgc atttgaataa tctggaaaca ggttagccgc 1020
aaggcaaatg tgaaggtgct gcatggttgt cgtcagctcg tgccgtgagg tgtcggctta 1080
agtgccataa cgagcgcaac ccttatcttt agttactaac aggtcatgct gaggactcta 1140
gagagactgc cgtcgtaaga tgtgaggaag gtggggatga cgtcaaatca gcacggccct 1200
tacgtccggg gctacacacg tgttacaatg gggggtacag aaggcagcta cctggcgaca 1260
ggatgctaat cccaaaaacc tctctcagtt cggatcgaag tctgcaaccc gacttcgtga 1320
agctggattc gctagtaatc gcgcatcagc catggcgcgg tgaatacgtt cccgggcctt 1380
gtacacaccg cccgtcaagc catgaaagcc gggggtacct gaagtacgta accgcaagga 1440
gcgtcctagg gtaaaactgg taattggggc taagtcgtaa caaggtagcc gtaccggaag 1500
gtgcggctgg aacacct 1517
<210> 39
<211> 1531
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_D20
<400> 39
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatgaa cttagcttgc taagtttgat ggcgaccggc gcacgggtga 120
gtaacacgta tccaacctgc cgatgactcg gggatagcct ttcgaaagaa agattaatac 180
ccgatggcat aattcttccg catggtagaa ctattaaaga atttcggtca tcgatgggga 240
tgcgttccat taggttgttg gcggggtaac ggcccaccaa gccttcgatg gataggggtt 300
ctgagaggaa ggtcccccac attggaactg agacacggtc caaactccta cgggaggcag 360
cagtgaggaa tattggtcaa tggacgagag tctgaaccag ccaagtagcg tgaaggatga 420
ctgccctatg ggttgtaaac ttcttttata cgggaataaa gtgaggcacg tgtgcctttt 480
tgtatgtacc gtatgaataa ggatcggcta actccgtgcc agcagccgcg gtaatacgga 540
ggatccgagc gttatccgga tttattgggt ttaaagggag cgtaggcgga cgcttaagtc 600
agttgtgaaa gtttgcggct caaccgtaaa attgcagttg atactgggtg tcttgagtac 660
agtagaggca ggcggaattc gtggtgtagc ggtgaaatgc ttagatatca cgaagaactc 720
cgattgcgaa ggcagcctgc tggactgtaa ctgacgctga tgctcgaaag tgtgggtatc 780
aaacaggatt agataccctg gtagtccaca cagtaaacga tgaatactcg ctgtttgcga 840
tatacagtaa gcggccaagc gaaagcgtta agtattccac ctggggagta cgccggcaac 900
ggtgaaactc aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc 960
gatgatacgc gaggaacctt acccgggctt gaattgcaac tgaatgatgt ggagacatgt 1020
cagccgcaag gcagttgtga aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt 1080
cggcttaagt gccataacga gcgcaaccct tatcgatagt taccatcagg ttatgctggg 1140
gactctgtcg agactgccgt cgtaagatgt gaggaaggtg gggatgacgt caaatcagca 1200
cggcccttac gtccggggct acacacgtgt tacaatgggg ggtacagaag gcagctacac 1260
ggcgacgtga tgctaatccc taaagcctct ctcagttcgg attggagtct gcaacccgac 1320
tccatgaagc tggattcgct agtaatcgcg catcagccac ggcgcggtga atacgttccc 1380
gggccttgta cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtgcgtaacc 1440
gcaaggagcg ccctagggta aaactggtga ttggggctaa gtcgtaacaa ggtagccgta 1500
ccggaaggtg cggctggaac acctcctttc t 1531
<210> 40
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_D22
<400> 40
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttt agtttgcttg caaactgaag atggcgaccg gcgcacgggt 120
gagtaacacg tatccaacct gccgataact cggggatagc ctttcgaaag aaagattaat 180
atccgatggt atattaaaac cgcatggttt tactattaaa gaatttcggt tatcgatggg 240
gatgcgttcc attagtttgt tggcggggta acggcccacc aagactacga tggatagggg 300
ttctgagagg aaggtccccc acattggaac tgagacacgg tccaaactcc tacgggaggc 360
agcagtgagg aatattggtc aatggacgag agtctgaacc agccaagtag cgtgaaggat 420
gactgcccta tgggttgtaa acttctttta tatgggaata aagtattcca cgtgtgggat 480
tttgtatgta ccatatgaat aaggatcggc taactccgtg ccagcagccg cggtaatacg 540
gaggatccga gcgttatccg gatttattgg gtttaaaggg agcgtaggtg gattgttaag 600
tcagttgtga aagtttgcgg ctcaaccgta aaattgcagt tgaaactggc agtcttgagt 660
acagtagagg tgggcggaat tcgtggtgta gcggtgaaat gcttagatat cacgaagaac 720
tccgattgcg aaggcagctc actagactgc aactgacact gatgctcgaa agtgtgggta 780
tcaaacagga ttagataccc tggtagtcca cacagtaaac gatgaatact cgctgtttgc 840
gatatacagt aagcggccaa gcgaaagcat taagtattcc acctggggag tacgccggca 900
acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat gtggtttaat 960
tcgatgatac gcgaggaacc ttacccgggc ttaaattgca aatgaataat ctggaaacag 1020
gttagccgca aggcatttgt gaaggtgctg catggttgtc gtcagctcgt gccgtgaggt 1080
gtcggcttaa gtgccataac gagcgcaacc cttatcttta gttactaaca ggtcatgctg 1140
aggactctag agagactgcc gtcgtaagat gtgaggaagg tggggatgac gtcaaatcag 1200
cacggccctt acgtccgggg ctacacacgt gttacaatgg ggggtacaga aggcagctac 1260
ctggcgacag gatgctaatc ccaaaaacct ctctcagttc ggatcgaagt ctgcaacccg 1320
acttcgtgaa gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc 1380
ccgggccttg tacacaccgc ccgtcaagcc atgaaagccg ggggtacctg aagtacgtaa 1440
ccgcaaggag cgtcctaggg taaaactggt aattggggct aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga acacctcctt tct 1533
<210> 41
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_D2
<400> 41
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatttt tctagcaata gaagagatgg cgaccggcgc acgggtgagt 120
aacacgtatc caacctaccg ataactccgg aatagccttt cgaaagaaag attaataccg 180
gatagtatac gaatatcgca tgatattttt attaaagaat ttcggttatc gatggggatg 240
cgttccatta gtttgttggc ggggtaacgg cccaccaaga ctacgatgga taggggttct 300
gagaggaagg tcccccacat tggaactgag acacggtcca aactcctacg ggaggcagca 360
gtgaggaata ttggtcaatg ggcgcaggcc tgaaccagcc aagtagcgtg aaggatgaag 420
gctctatggg tcgtaaactt cttttatatg ggaataaagt tttccacgtg tggaattttg 480
tatgtaccat atgaataagg atcggctaac tccgtgccag cagccgcggt aatacggagg 540
atccgagcgt tatccggatt tattgggttt aaagggagcg taggtggatt gttaagtcag 600
ttgtgaaagt ttgcggctca accgtaaaat tgcagttgaa actggagtct tgagtacagt 660
agaggtgggc ggaattcgtg gtgtagcggt gaaatgctta gatatcacga agaactccga 720
ttgcgaaggc agctcactag actgttactg acactgatgc tcgaaagtgt gggtatcaaa 780
caggattaga taccctggta gtccacacag taaacgatga atactcgctg tttgcgatat 840
acagtaagcg gccaagcgaa agcattaagt attccacctg gggagtacgc cggcaacggt 900
gaaactcaaa ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat 960
gatacgcgag gaaccttacc cgggcttaaa ttgcaaatga atatgtagga aactatatag 1020
ccgcaaggca tttgtgaagg tgctgcatgg ttgtcgtcag ctcgtgccgt gaggtgtcgg 1080
cttaagtgcc ataacgagcg caacccttat ctttagttac taacaggtta tgctgaggac 1140
tctagagaga ctgccgtcgt aagatgtgag gaaggtgggg atgacgtcaa atcagcacgg 1200
cccttacgtc cggggctaca cacgtgttac aatggggggt acagaaggca gctacacggc 1260
gacgtgatgc taatcccaaa aacctctctc agttcggatc gaagtctgca acccgacttc 1320
gtgaagctgg attcgctagt aatcgcgcat cagccatggc gcggtgaata cgttcccggg 1380
ccttgtacac accgcccgtc aagccatgaa agccgggggt acctgaagta cgtaaccgca 1440
aggagcgtcc tagggtaaaa ctggtaattg gggctaagtc gtaacaaggt agccgtaccg 1500
gaaggtgcgg ctggaacacc tcctttct 1528
<210> 42
<211> 1488
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_sp_F_4
<400> 42
agagtttgat catggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcatga acttagcttg ctaagtttga tggcgaccgg cgcacgggtg agtaacacgt 120
atccaacctg ccgatgactc ggggatagcc tttcgaaaga aagattaata cccgatggca 180
tagttcttcc gcatggtgga actattaaag aatttcggtc atcgatgggg atgcgttcca 240
ttaggttgtt ggcggggtaa cggcccacca agccttcgat ggataggggt tctgagagga 300
aggtccccca cattggaact gagacacggt ccaaactcct acgggaggca gcagtgagga 360
atattggtca atggacgaga gtctgaacca gccaagtagc gtgaaggatg actgccctat 420
gggtcgtaaa cttcttttat acgggaataa agtgaggcac gtgtgccttt ttgtatgtac 480
cgtatgaata aggatcggct aactccgtgc cagcagccgc ggtaatacgg aggatccgag 540
cgttatccgg atttattggg tttaaaggga gcgtaggcgg acgcttaagt cagttgtgaa 600
agtttgcggc tcaaccgtaa aattgcagtt gatactgggt gtcttgagta cagtagaggc 660
aggcggaatt cgtggtgtag cggtgaaatg cttagatatc acgaagaact ccgattgcga 720
aggcagcttg ctggactgta actgacgctg atgctcgaaa gtgtgggtat caaacaggat 780
tagataccct ggtagtccac acagtaaacg atgaatactc gctgtttgcg atatacagta 840
agcggccaag cgaaagcgtt aagtattcca cctggggagt acgccggcaa cggtgaaact 900
caaaggaatt gacgggggcc cgcacaagcg gaggaacatg tggtttaatt cgatgatacg 960
cgaggaacct tacccgggct tgaattgcaa ctgaatgatg tggagacatg tcagccgcaa 1020
ggcagttgtg aaggtgctgc atggttgtcg tcagctcgtg ccgtgaggtg tcggcttaag 1080
tgccataacg agcgcaaccc ttatcgatag ttaccatcag gttatgctgg ggactctgtc 1140
gagactgccg tcgtaagatg tgaggaaggt ggggatgacg tcaaatcagc acggccctta 1200
cgtccggggc tacacacgtg ttacaatggg gggtacagaa ggcagctaca cggcgacgtg 1260
atgctaatcc ctaaagcctc tctcagttcg gattggagtc tgcaacccga ctccatgaag 1320
ctggattcgc tagtaatcgc gcatcagcca cggcgcggtg aatacgttcc cgggccttgt 1380
acacaccgcc cgtcaagcca tgaaagccgg gggtacctga agtgcgtaac cgcaaggagc 1440
gccctagggt aaaactggtg attggggcta agtcgtaaca aggtagcc 1488
<210> 43
<211> 1531
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_stercoris
<400> 43
ttacaatgaa gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc 60
aagtcgaggg gcagcatcat caaagcttgc tttgatggat ggcgaccggc gcacgggtga 120
gtaacacgta tccaacctgc cgacaacact gggatagcct ttcgaaagaa agattaatac 180
cggatggcat agttttcccg catgggataa ttattaaaga atttcggttg tcgatgggga 240
tgcgttccat taggcagttg gcggggtaac ggcccaccaa accaacgatg gataggggtt 300
ctgagaggaa ggtcccccac attggaactg agacacggtc caaactccta cgggaggcag 360
cagtgaggaa tattggtcaa tggacgagag tctgaaccag ccaagtagcg tgaaggatga 420
ctgccctatg ggttgtaaac ttcttttata cgggaataaa gtgagccacg tgtggctttt 480
tgtatgtacc gtatgaataa ggatcggcta actccgtgcc agcagccgcg gtaatacgga 540
ggatccgagc gttatccgga tttattgggt ttaaagggag cgtaggcggg ttgttaagtc 600
agttgtgaaa gtttgcggct caaccgtaaa attgcagttg atactggcga ccttgagtgc 660
aacagaggta ggcggaattc gtggtgtagc ggtgaaatgc ttagatatca cgaagaactc 720
cgattgcgaa ggcagcttac tggattgtaa ctgacgctga tgctcgaaag tgtgggtatc 780
aaacaggatt agataccctg gtagtccaca cagtaaacga tgaatactcg ctgttggcga 840
tatacagtca gcggccaagc gaaagcatta agtattccac ctggggagta cgccggcaac 900
ggtgaaactc aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc 960
gatgatacgc gaggaacctt acccgggctt aaattgcaac tgactgaatc ggaaacggtt 1020
ctttcttcgg acagttgtga aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt 1080
cggcttaagt gccataacga gcgcaaccct tacgggtagt taccatcagg ttatgctggg 1140
gactctaccc ggactgccgt cgtaagatgt gaggaaggtg gggatgacgt caaatcagca 1200
cggcccttac gtccggggct acacacgtgt tacaatgggg ggtacagaag gcagctacac 1260
ggcgacgtgg tgctaatccc gaaagcctct ctcagttcgg attggagtct gcaacccgac 1320
tccatgaagc tggattcgct agtaatcgcg catcagccac ggcgcggtga atacgttccc 1380
gggccttgta cacaccgccc gtcaagccat gaaagccggg ggtacctgaa gtacgtaacc 1440
gcgaggagcg tcctagggta aaactggtga ttggggctaa gtcgtaacaa ggtagccgta 1500
ccggaaggtg cggctggaac acctcctttc t 1531
<210> 44
<211> 1342
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_stercoris
<220>
<221> misc_feature
<222> (164)..(164)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (179)..(179)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (436)..(436)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (996)..(996)
<223> n is a, c, g, or t
<400> 44
atgaacgcta gctacaggct taacacatgc aagtcgaggg gcagcatcat caaagcttgc 60
tttgatggat ggcgaccggc gcacgggtga gtaacacgta tccaacctgc cgacaacact 120
gggatagcct ttcgaaagaa agattaatac cggatggcat agtnttcccg catgggatna 180
ttattaaaga atttcggttg tcgatgggga tgcgttccat taggcagttg gcggggtaac 240
ggcccaccaa acctacgatg gataggggtt ctgagaggaa ggtcccccac attggaactg 300
agacacggtc caaactccta cgggaggcag cagtgaggaa tattggtcaa tggacgagag 360
tctgaaccag ccaagtagcg tgaaggatga ctgccctatg ggttgtaaac ttcttttata 420
cgggaataaa gtgcangacg tgtggctttt tgtatgtacc gtatgaataa ggatcggcta 480
actccgtgcc agcagccgcg gtaatacgga ggatccgagc gttatccgga tttattgggt 540
ttaaagggag cgtaggcggg ttgttaagtc agttgtgaaa gtttgcggct caaccgtaaa 600
attgcagttg atactggcga ccttgagtgc aacagaggta ggcggaattc gtggtgtagc 660
ggtgaaatgc ttagatatca cgaagaactc cgattgcgaa ggcagcttac tggattgtaa 720
ctgacgctga tgctcgaaag tgtgggtatc aaacaggatt agataccctg gtagtccaca 780
cagtaaacga tgaatactcg ctgttggcga tatacagtca gcggccaagc gaaagcatta 840
agtattccac ctggggagta cgccggcaac ggtgaaactc aaaggaattg acgggggccc 900
gcacaagcgg aggaacatgt ggtttaattc gatgatacgc gaggaacctt acccgggctt 960
aaattgcaac tgactgaatc ggaaacggtt ctttcnttcg gacagttgtg aaggtgctgc 1020
atggttgtcg tcagctcgtg ccgtgaggtg tcggcttaag tgccataacg agcgcaaccc 1080
ttacgggtag ttaccatcag gttatgctgg ggactctacc cggactgccg tcgtaagatg 1140
tgaggaaggt ggggatgacg tcaaatcagc acggccctta cgtccggggc tacacacgtg 1200
ttacaatggg gggtacagaa ggcagctaca cggcgacgtg gtgctaatcc cgaaagcctc 1260
tctcagttcg gattggagtc tgcaacccga ctccatgaag ctggattcgc tagtaatcgc 1320
gcatcagcca cggcgcggtg aa 1342
<210> 45
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 45
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat gactcgggga tagcctttcg 120
aaagaaagat taatacccga tggttaaagt cggtcattga tggggatgcg ttccattagg 180
ttgttggcgg ggtaacggcc caccaagccg tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggatgcttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg gtgtcttgag tacagtagag gcaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tgctggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agtaagcggc caagcgaaag cgttaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttaaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatcga tagttaccat cagctgggga ctctgtcgag actgccgtcg taagatggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc cggggctaca cacgtgttac 1080
aatggggggc agaaggcagc tacacggtga cgtgatgcta atccctcctc tctcagttcg 1140
gatggagtct gcaacccgac tccagaagct ggattcgcta gtaatcgcgc atcagccacg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg aaagccgggg 1260
gtacctgaag tgcgtagcgc cctagggtaa aactggtgat tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 46
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 46
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat gactcgggga tagcctttcg 120
aaagaaagat taatacccga tggttaaagt cggtcattga tggggatgcg ttccattagg 180
ttgttggcgg ggtaacggcc caccaagcca tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggatgcttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg gtgtcttgag tacagtagag gcaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tgctggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agtaagcggc caagcgaaag cgttaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttaaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatcga tagttaccat cagctgggga ctctgtcgag actgccgtcg taagatggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc cggggctaca cacgtgttac 1080
aatggggggc agaaggcagc tacacggtga cgtgatgcta atccctcctc tctcagttcg 1140
gatggagtct gcaacccgac tccagaagct ggattcgcta gtaatcgcgc atcagccacg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg aaagccgggg 1260
gtacctgaag tgcgtagcgc cctagggtaa aactggtgat tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 47
<211> 1425
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 47
gtttgatcat ggctcaggat gaacgctagt acaggcttaa cacatgcaag tcgaggggca 60
gcatgaactt agcttgctaa gtttgatggc gaccggcgca cgggtgagta acacgtatcc 120
aacctgccga tgactcgggg atagcctttc gaaagaaaga ttaatacccg atggcatagt 180
tcttccgcat ggtagaacta ttaaagaatt tcggtcatcg atggggatgc gttccattag 240
gttgttggcg gggtaacggc ccaccaagcc ttcgatggat aggggttctg agaggaaggt 300
cccccacatt ggaactgaga cacggtccaa actcctacgg gaggcagcag tgaggaatat 360
tggtcaatgg acgagagtct gaaccagcca agtagcgtga aggatgactg ccctatgggt 420
tgtaaacttc ttttatacgg gaataaagtg aggcacgtgt gcctttttgt atgtaccgta 480
tgaataagga tcggctaact ccgtgccagc agccgcggta atacggagga tccgagcgtt 540
atccggattt attgggttta aagggagcgt aggcggacgc ttaagtcagt tgtgaaagtt 600
tgcggctcaa ccgtaaaatt gcagttgata ctgggtgtct tgagtacagt agaggcaggc 660
ggaattcgtg gtgtagcggt gaaatgctta gatatcacga agaactccga ttgcgaaggc 720
agcttgctgg actgtaactg acgctgatgc tcgaaagtgt gggtatcaaa caggattaga 780
taccctggta gtccacacag taaacgatga atactcgctg tttgcgatat acagtaagcg 840
gccaagcgaa agcgttaagt attccacctg gggagtacgc cggcaacggt gaaactcaaa 900
ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat gatacgcgag 960
gaaccttacc cgggcttgaa ttgcaactga atgatgtgga gacatgtcag ccgcaaggca 1020
gttgtgaagg tgctgcatgg ttgtcgtcag ctcgtgccgt gaggtgtcgg cttaagtgcc 1080
ataacgagcg caacccttat cgatagttac catcaggtta tgctggggac tctgtcgaga 1140
ctgccgtcgt aagatgtgag gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc 1200
cggggctaca cacgtgttac aatggggggt acagaaggca gctacacggc gacgtgatgc 1260
taatccctaa agcctctctc agttcggatt ggagtctgca acccgactcc atgaagctgg 1320
attcgctagt aatcgcgcat cagccacggc gcggtgaata cgttcccggg ccttgtacac 1380
accgcccgtc aagccatgaa agccgggggt acctgaagtg cgtaa 1425
<210> 48
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 48
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat gactcgggga tagcctttcg 120
aaagaaagat taatacccga tggctaaagt cggtcatcga tggggatgcg ttccattagg 180
ttgttggcgg ggtaacggcc caccaagcct tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggacgcttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg gtgtcttgag tacagtagag gcaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tgctggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agtaagcggc caagcgaaag cgttaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttgaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatcga tagttaccat cagctgggga ctctgtcgag actgccgtcg taagatggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc cggggctaca cacgtgttac 1080
aatggggggc agaaggcagc tacacggcga cgtgatgcta atcccgcctc tctcagttcg 1140
gatggagtct gcaacccgac tccagaagct ggattcgcta gtaatcgcgc atcagccacg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg aaagccgggg 1260
gtacctgaag tgcgtagcgc cctagggtaa aactggtgat tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 49
<211> 1323
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 49
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat gactcgggga tagcctttcg 120
aaagaaagat taatacccga tggttaaagt cggtcattga tggggatgcg ttccattagg 180
ttgttggcgg ggtaacggcc caccaagcca tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggatgcttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg gtgtcttgag tacagtagag gcaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tgctggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agtaagcggc caagcgaaag cgttaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttaaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgcaacg agcgcaaccc 960
ttatcgatag ttaccatcag ctggggactc tgtcgagact gccgtcgtaa gatggaggaa 1020
ggtggggatg acgtcaaatc agcacggccc ttacgtccgg ggctacacac gtgttacaat 1080
ggggggcaga aggcagctac acggtgacgt gatgctaatc cctcctctct cagttcggat 1140
ggagtctgca acccgactcc agaagctgga ttcgctagta atcgcgcatc agccacggcg 1200
cggtgaatac gttcccgggc cttgtacaca ccgcccgtca agccatgaaa gccgggggta 1260
cctgaagtgc gtagcgccct agggtaaaac tggtgattgg ggctaagtcg taacaaggta 1320
acc 1323
<210> 50
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 50
gagtttgatc ctggctcagg atgaacgcta gctacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cacgtatcca acctgccgat gactcgggga tagcctttcg 120
aaagaaagat taatacccga tggctaaagt cggtcatcga tggggatgcg ttccattagg 180
ttgttggcgg ggtaacggcc caccaagcct tcgatggata ggggttctga gaggaaggtc 240
ccccacattg gaactgagac acggtccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatgga cgagagtctg aaccagccaa gtagcgtgaa ggatgactgc ctatgggttg 360
taaacttctt ttatacggga atatgtatgt accgtatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gagcgtaggc ggacgcttaa gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag 540
ttgatactgg gtgtcttgag tacagtagag gcaggcggaa ttcgtggtgt agcggtgaaa 600
tgcttagata tcacgaagaa ctccgattgc gaaggcagct tgctggactg actgacgctg 660
atgctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acagtaaacg 720
atgaatactc gctgtttgcg agtaagcggc caagcgaaag cgttaagtat tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggcttgaatt gtgaaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatcga tagttaccat cagctgggga ctctgtcgag actgccgtcg taagatggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacgtc cggggctaca cacgtgttac 1080
aatggggggc agaaggcagc tacacggcga cgtgatgcta atccctcctc tctcagttcg 1140
gatggagtct gcaacccgac tccagaagct ggattcgcta gtaatcgcgc atcagccacg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg aaagccgggg 1260
gtacctgaag tgcgtagcgc cctagggtaa aactggtgat tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 51
<211> 1240
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 51
caggcttaac acatgcaagt cgagggaccg gcgcacgggt gagtaacacg tatccaacct 60
gccgatgact cggggatagc ctttcgaaag aaagattaat acccgatggc taaagtcggt 120
catcgatggg gatgcgttcc attaggttgt tggcggggta acggcccacc aagccttcga 180
tggatagggg ttctgagagg aaggtccccc acattggaac tgagacacgg tccaaactcc 240
tacgggaggc agcagtgagg aatattggtc aatggacgag agtctgaacc agccaagtag 300
cgtgaaggat gactgcctat gggttgtaaa cttcttttat acgggaatat gtatgtaccg 360
tatgaataag gatcggctaa ctccgtgcca gcagccgcgg taatacggag gatccgagcg 420
ttatccggat ttattgggtt taaagggagc gtaggcggac gcttaagtca gttgtgaaag 480
tttgcggctc aaccgtaaaa ttgcagttga tactgggtgt cttgagtaca gtagaggcag 540
gcggaattcg tggtgtagcg gtgaaatgct tagatatcac gaagaactcc gattgcgaag 600
gcagcttgct ggactgactg acgctgatgc tcgaaagtgt gggtatcaaa caggattaga 660
taccctggta gtccacacag taaacgatga atactcgctg tttgcgagta agcggccaag 720
cgaaagcgtt aagtattcca cctggggagt acgccggcaa cggtgaaact caaaggaatt 780
gacgggggcc cgcacaagcg gaggaacatg tggtttaatt cgatgatacg cgaggaactt 840
acccgggctt gaattgtgaa ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc 900
ggcttaagtg ccataacgag cgcaaccctt atcgatagtt accatcagct ggggactctg 960
tcgagactgc cgtccgtaag atggaggaag gtggggatga cgtcaaatca gcacggccct 1020
tacgtccggg gctacacacg tgttacaatg gggggcagaa ggcagctaca cggcgacgtg 1080
atgctaatcc ctcctctctc agttcggatg gagtctgcaa cccgactcca gaagctggat 1140
tcgctagtaa tcgcgcatca gccacagcgc ggtgaatacg tcccgggcct tgtacacacc 1200
gcccgtcaag ccatgaaacc gggggtacct gaagtgcgta 1240
<210> 52
<211> 1305
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_uniformis
<400> 52
tttgatcatg gctcaggatg aacgctagct acaggcttaa cacatgcaag tcgagggacc 60
ggcgcacggg tgagtaacac gtatccaacc tgccgatgac tcggggatag cctttcgaaa 120
gaaagattaa tacccgatgg ctaaagtcgg tcatcgatgg ggatgcgttc cattaggttg 180
ttggcggggt aacggcccac caagccttcg atggataggg gttctgagag gaaggtcccc 240
cacattggaa ctgagacacg gtccaaactc ctacgggagg cagcagtgag gaatattggt 300
caatggacga gagtctgaac cagccaagta gcgtgaagga tgactgccta tgggttgtaa 360
acttctttta tacgggaata tgtatgtacc gtatgaataa ggatcggcta actccgtgcc 420
agcagccgcg gtaatacgga ggatccgagc gttatccgga tttattgggt ttaaagggag 480
cgtaggcgga cgcttaagtc agttgtgaaa gtttgcggct caaccgtaaa attgcagttg 540
atactgggtg tcttgagtac agtagaggca ggcggaattc gtggtgtagc ggtgaaatgc 600
ttagatatca cgaagaactc cgattgcgaa ggcagcttgc tggactgact gacgctgatg 660
ctcgaaagtg tgggtatcaa acaggattag ataccctggt agtccacaca gtaaacgatg 720
aatactcgct gtttgcgagt aagcggccaa gcgaaagcgt taagtattcc acctggggag 780
tacgccggca acggtgaaac tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat 840
gtggtttaat tcgatgatac gcgaggaact tacccgggct tgaattgtga aggtgctgca 900
tggttgtcgt cagctcgtgc cgtgaggtgt cggcttaagt gccataacga gcgcaaccct 960
tatcgatagt taccatcagc tggggactct gtcgagactg ccgtcgtaag atggaggaag 1020
gtggggatga cgtcaaatca gcacggccct tacgtccggg gctacacacg tgttacaatg 1080
gggggcagaa ggcagctaca cggcgacgtg atgctaatcc ctcctctctc agttcggatg 1140
gagtctgcaa cccgactcca gaagctggat tcgctagtaa tcgcgcatca gccacggcgc 1200
ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcaa gccatgaaag ccgggggtac 1260
ctgaagtgcg tagcgcccta gggtaaaact ggtgattggg gctaa 1305
<210> 53
<211> 1510
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_vulgatus
<400> 53
tattacaatg aagagtttga tcctggctca ggatgaacgc tagctacagg cttaacacat 60
gcaagtcgag gggcagcatg gtcttagctt gctaagactg atggcgaccg gcgcacgggt 120
gagtaacacg tatccaacct gccgtctact cttggacagc cttctgaaag gaagattaat 180
acaagatggc atcatgagtc cgcatgttca catgattaaa ggtattccgg tagacgatgg 240
ggatgcgttc cattagatag taggcggggt aacggcccac ctagtcttcg atggataggg 300
gttctgagag gaaggtcccc cacattggaa ctgagacacg gtccaaactc ctacgggagg 360
cagcagtgag gaatattggt caatgggcgc aggcctgaac cagccaagta gcgtgaagga 420
tgactgccct atgggttgta aacttctttt ataaaggaat aaagtcgggt atggataccc 480
gtttgcatgt actttatgaa taaggatcgg ctaactccgt gccagcagcc gcggtaatac 540
ggaggatccg agcgttatcc ggatttattg ggtttaaagg gagcgtagat ggatgtttaa 600
gtcagttgtg aaagtttgcg gctcaaccgt aaaattgcag ttgatactgg atatcttgag 660
tgcagttgag gcaggcggaa ttcgtggtgt agcggtgaaa tgcttagata tcacgaagaa 720
ctccgattgc gaaggcagcc tgctaagctg caactgacat tgaggctcga aagtgtgggt 780
atcaaacagg attagatacc ctggtagtcc acacggtaaa cgatgaatac tcgctgtttg 840
cgatatacgg caagcggcca agcgaaagcg ttaagtattc cacctgggga gtacgccggc 900
aacggtgaaa ctcaaaggaa ttgacggggg cccgcacaag cggaggaaca tgtggtttaa 960
ttcgatgata cgcgaggaac cttacccggg cttaaattgc agatgaatta cggtgaaagc 1020
cgtaagccgc aaggcatctg tgaaggtgct gcatggttgt cgtcagctcg tgccgtgagg 1080
tgtcggctta agtgccataa cgagcgcaac ccttgttgtc agttactaac aggtttcgct 1140
gaggactctg acaagactgc catcgtaaga tgtgaggaag gtggggatga cgtcaaatca 1200
gcacggccct tacgtccggg gctacacacg tgttacaatg gggggtacag agggccgcta 1260
ccacgcgagt ggatgccaat cccaaaaacc tctctcagtt cggactggag tctgcaaccc 1320
gactccacga agctggattc gctagtaatc gcgcatcagc cacggcgcgg tgaatacgtt 1380
cccgggcctt gtacacaccg cccgtcaagc catgggagcc gggggtacct gaagtgcgta 1440
accgcgagga gcgccctagg gtaaaactgg tgactggggc taagtcgtaa caaggtagcc 1500
gtaccggaag 1510
<210> 54
<211> 1374
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_vulgatus
<400> 54
tctgaaagga agattaatac aagatggcat catgagtccg catgttcaca tgattaaagg 60
tattccggta gacgatgggg atgcgttcca ttagatagta ggcggggtaa cggcccacct 120
agtcttcgat ggataggggt tctgagagga aggtccccca cattggaact gagacacggt 180
ccaaactcct acgggaggca gcagtgagga atattggtca atgggcgaga gcctgaacca 240
gccaagtagc gtgaaggatg actgccctat gggttgtaaa cttcttttat aaaggaataa 300
agtcgggtat gtatacccgt ttgcatgtac tttatgaata aggatcggct aactccgtgc 360
cagcagccgc ggtaatacgg aggatccgag cgttatccgg atttattggg tttaaaggga 420
gcgtagatgg atgtttaagt cagttgtgaa agtttgcggc tcaaccgtaa aattgcagtt 480
gatactggat atcttgagtg cagttgaggc aggcggaatt cgtggtgtag cggtgaaatg 540
cttagatatc acgaagaact ccgattgcga aggcagcctg ctaagctgca actgacattg 600
aggctcgaaa gtgtgggtat caaacaggat tagataccct ggtagtccac acggtaaacg 660
atgaatactc gctgtttgcg atatactgca agcggccaag cgaaagcgtt aagtattcca 720
cctggggagt acgccggcaa cggtgaaact caaaggaatt gacgggggcc cgcacaagcg 780
gaggaacatg tggtttaatt cgatgatacg cgaggaacct tacccgggct taaattgcag 840
atgaattacg gtgaaagccg taagccgcaa ggcatctgtg aaggtgctgc atggttgtcg 900
tcagctcgtg ccgtgaggtg tcggcttaag tgccataacg agcgcaaccc ttgttgtcag 960
ttactaacag gttccgctga ggactctgac aagactgcca tcgtaagatg tgaggaaggt 1020
ggggatgacg tcaaatcagc acggccctta cgtccggggc tacacacgtg ttacaatggg 1080
gggtacagag ggccgctacc acgcgagtgg atgccaatcc ccaaaacctc tctcagttcg 1140
gactggagtc tgcaacccga ctccacgaag ctggattcgc tagtaatcgc gcatcagcca 1200
cggcgcggtg aatacgttcc cgggccttgt acacaccgcc cgtcaagcca tgggagccgg 1260
gggtacctga agtgcgtaac cgcgaggagc gccctagggt aaaactggtg actggggcta 1320
agtcgtaaca aggtagccgt accggaaggt gcggctggaa cacctccttc tgaa 1374
<210> 55
<211> 1508
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_vulgatus
<400> 55
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcatgg tcttagcttg ctaaggccga tggcgaccgg cgcacgggtg agtaacacgt 120
atccaacctg ccgtctactc ttggacagcc ttctgaaagg aagattaata caagatggca 180
tcatgagtcc gcatgttcac atgattaaag gtattccggt agacgatggg gatgcgttcc 240
attagatagt aggcggggta acggcccacc tagtcttcga tggatagggg ttctgagagg 300
aaggtccccc acattggaac tgagacacgg tccaaactcc tacgggaggc agcagtgagg 360
aatattggtc aatgggcgag agcctgaacc agccaagtag cgtgaaggat gactgcccta 420
tgggttgtaa acttctttta taaaggaata aagtcgggta tgtatacccg tttgcatgta 480
ctttatgaat aaggatcggc taactccgtg ccagcagccg cggtaatacg gaggatccga 540
gcgttatccg gatttattgg gtttaaaggg agcgtagatg gatgtttaag tcagttgtga 600
aagtttgcgg ctcaaccgta aaattgcagt tgatactgga tatcttgagt gcagttgagg 660
caggcggaat tcgtggtgta gcggtgaaat gcttagatat cacgaagaac tccgattgcg 720
aaggcagcct gctaagctgc aactgacatt gaggctcgaa agtgtgggta tcaaacagga 780
ttagataccc tggtagtcca cacggtaaac gatgaatact cgctgtttgc gatatactgc 840
aagcggccaa gcgaaagcgt taagtattcc acctggggag tacgccggca acggtgaaac 900
tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat gtggtttaat tcgatgatac 960
gcgaggaacc ttacccgggc ttaaattgca gatgaattac ggtgaaagcc gtaagccgca 1020
aggcatctgt gaaggtgctg catggttgtc gtcagctcgt gccgtgaggt gtcggcttaa 1080
gtgccataac gagcgcaacc cttgttgtca gttactaaca ggttccgctg aggactctga 1140
caagactgcc atcgtaagat gtgaggaagg tggggatgac gtcaaatcag cacggccctt 1200
acgtccgggg ctacacacgt gttacaatgg ggggtacaga gggccgctac cacgcgagtg 1260
gatgccaatc cccaaaacct ctctcagttc ggactggagt ctgcaacccg actccacgaa 1320
gctggattcg ctagtaatcg cgcatcagcc acggcgcggt gaatacgttc ccgggccttg 1380
tacacaccgc ccgtcaagcc atgggagccg ggggtacctg aagtgcgtaa ccgcgaggag 1440
cgccctaggg taaaactggt gactggggct aagtcgtaac aaggtagccg taccggaagg 1500
tgcggctg 1508
<210> 56
<211> 1465
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_xylanisolvens
<400> 56
gctcaggatg aacgctagct acaggcttaa cacatgcaag tcgaggggca gcattttagt 60
ttgcttgcaa actaaagatg gcgaccggcg cacgggtgag taacacgtat ccaacctgcc 120
gataactcgg ggatagcctt tcgaaagaaa gattaatatc cgatagtata ttaaaaccgc 180
atggttttac tattaaagaa tttcggttat cgatggggat gcgttccatt agtttgttgg 240
cggggtaacg gcccaccaag actacgatgg ataggggttc tgagaggaag gtcccccaca 300
ttggaactga gacacggtcc aaactcctac gggaggcagc agtgaggaat attggtcaat 360
ggacgagagt ctgaaccagc caagtagcgt gaaggatgac tgccctatgg gttgtaaact 420
tcttttatat gggaataaag tattccacgt gtggratttt gtatgtacca tatgaataag 480
gatcggctaa ctccgtgcca gcagccgcgg taatacggag gatccgagcg ttatccggat 540
ttattgggtt taaagggagc gtaggtggat tgttaagtca gttgtgaaag tttgcggctc 600
aaccgtaaaa ttgcagttga aactggcagt cttgagtaca gtagaggtgg gcggaattcg 660
tggtgtagcg gtgaaatgct tagatatcac gaagaactcc gattgcgaag gcagctcact 720
agactgcaac tgacactgat gctcgaaagt gtgggtatca aacaggatta gataccctgg 780
tagtccacac agtaaacgat gaatactcgc tgtttgcgat atacagtaag cggccaagcg 840
aaagcattaa gtattccacc tggggagtac gccggcaacg gtgaaactca aaggaattga 900
cgggggcccg cacaagcgga ggaacatgtg gtttaattcg atgatacgcg aggaacctta 960
cccgggctta aattgcaaat gaataatctg gaaacaggtt agccgcaagg catttgtgaa 1020
ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc ggcttaagtg ccataacgag 1080
cgcaaccctt atctttagtt actaacaggt tatgctgagg actctagaga gactgccgtc 1140
gtaagatgtg aggaaggtgg ggatgacgtc aaatcagcac ggcccttacg tccggggcta 1200
cacacgtgtt acaatggggg gtacagaagg cagctacctg gcgacaggat gctaatccca 1260
aaaacctctc tcagttcgga tcgaagtctg caacccgact tcgtgaagct ggattcgcta 1320
gtaatcgcgc atcagccatg gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg 1380
tcaagccatg aaagccgggg gtacctgaag tacgtaaccg caaggagcgt cctagggtaa 1440
aactggtaat tggggctaag tcgta 1465
<210> 57
<211> 1508
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_xylanisolvens
<400> 57
agagtttgat cctggctcag gatgaacgct agctacaggc ttaacacatg caagtcgagg 60
ggcagcattt tagtttgctt gcaaactaaa gatggcgacc ggcgcacggg tgagtaacac 120
gtatccaacc tgccgataac tcggggatag cctttcgaaa gaaagattaa tatccgatag 180
tatattaaac cgcatggttt tactattaaa gaatttcggt tatcgatggg gatgcgttcc 240
attagtttgt tggcggggta acggcccacc aagactacga tggatagggg ttctgagagg 300
aaggtccccc acattggaac tgagacacgg tccaaactcc tacgggaggc agcagtgagg 360
aatattggtc aatggacgag agtctgaacc agccaagtag cgtgaaggat gactgcccta 420
tgggttgtaa acttctttta tatgggaata aagtattcca cgtgtggaat tttgtatgta 480
ccatatgaat aaggatcggc taactccgtg ccagcagccg cggtaatacg gaggatccga 540
gcgttatccg gatttattgg gtttaaaggg agcgtaggtg gattgttaag tcagttgtga 600
aagtttgcgg ctcaaccgta aaattgcagt tgaaactggc agtcttgagt acagtagagg 660
tgggcggaat tcgtggtgta gcggtgaaat gcttagatat cacgaagaac tccgattgcg 720
aaggcagctc actagactgc aactgacact gatgctcgaa agtgtgggta tcaaacagga 780
ttagataccc tggtagtcca cacagtaaac gatgaatact cgctgtttgc gatatacagt 840
aagcggccaa gcgaaagcat taagtattcc acctggggag tacgccggca acggtgaaac 900
tcaaaggaat tgacgggggc ccgcacaagc ggaggaacat gtggtttaat tcgatgatac 960
gcgaggaacc ttacccgggc ttaaattgca tttgaataat ctggaaacag gttagccgca 1020
aggcaaatgt gaaggtgctg catggttgtc gtcagctcgt gccgtgaggt gtcggcttaa 1080
gtgccataac gagcgcaacc cttatcttta gttactaaca ggtcatgctg aggactctag 1140
agagactgcc gtcgtaagat gtgaggaagg tggggatgac gtcaaatcag cacggccctt 1200
acgtccgggg ctacacacgt gttacaatgg ggggtacaga aggcagctac ctggcgacag 1260
gatgctaatc ccaaaaacct ctctcagttc ggatcgaagt ctgcaacccg acttcgtgaa 1320
gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc ccgggccttg 1380
tacacaccgc ccgtcaagcc atgaaagccg ggggtacctg aagtacgtaa ccgcaaggag 1440
cgtcctaggg taaaactggt aattggggct aagtcgtaac aaggtagccg taccggaagg 1500
tgcggctg 1508
<210> 58
<211> 1368
<212> DNA
<213> Artificial Sequence
<220>
<223> Bacteroides_xylanisolvens
<400> 58
catgcaagtc gaggggcagc attttagttt gcttgcaaac taaagatggc gaccggcgca 60
cgggtgagta acacgtatcc aacctgccga taactcgggg atagcctttc gaaagaaaga 120
ttaatatccg atagtatatt aaaaccgcat ggttttacta ttaaagaatt tcggttatcg 180
atggggatgc gttccattag tttgttggcg gggtaacggc ccaccaagac tacgatggat 240
aggggttctg agaggaaggt cccccacatt ggaactgaga cacggtccaa actcctacgg 300
gaggcagcag tgaggaatat tggtcaatgg acgagagtct gaaccagcca agtagcgtga 360
aggatgactg ccctatgggt tgtaaacttc ttttatatgg gaataaagta ttccacgtgt 420
gggattttgt atgtaccata tgaataagga tcggctaact ccgtgccagc agccgcggta 480
atacggagga tccgagcgtt atccggattt attgggttta aagggagcgt aggtggattg 540
ttaagtcagt tgtgaaagtt tgcggctcaa ccgtaaaatt gcagttgaaa ctggcagtct 600
tgagtacagt agaggtgggc ggaattcgtg gtgtagcggt gaaatgctta gatatcacga 660
agaactccga ttgcgaaggc agctcactag actgcaactg acactgatgc tcgaaagtgt 720
gggtatcaaa caggattaga taccctggta gtccacacag taaacgatga atactcgctg 780
tttgcgatat acagtaagcg gccaagcgaa agcattaagt attccacctg gggagtacgc 840
cggcaacggt gaaactcaaa ggaattgacg ggggcccgca caagcggagg aacatgtggt 900
ttaattcgat gatacgcgag gaaccttacc cgggcttaaa ttgcaaatga ataatctgga 960
aacaggttag ccgcaaggca tttgtgaagg tgctgcatgg ttgtcgtcag ctcgtgccgt 1020
gaggtgtcgg cttaagtgcc ataacgagcg caacccttat ctttagttac taacaggtta 1080
tgctgaggac tctagagaga ctgccgtcgt aagatgtgag gaaggtgggg atgacgtcaa 1140
atcagcacgg cccttacgtc cggggctaca cacgtgttac aatggggggt acagaaggca 1200
gctacctggc gacaggatgc taatcccaaa aacctctctc agttcggatc gaagtctgca 1260
acccgacttc gtgaagctgg attcgctagt aatcgcgcat cagccatggc gcggtgaata 1320
cgttcccggg ccttgtacac accgcccgtc aagccatgaa agccgggg 1368
<210> 59
<211> 1316
<212> DNA
<213> Artificial Sequence
<220>
<223> Barnesiella_intestinihominis
<400> 59
gatgaacgct agcgacaggc ctaacacatg caagtcgagg gaccggcgca cgggtgagta 60
acacgtatgc aatccacctg taacaggggg ataacccgga gaaatccgga ctaatacccc 120
ataattaaag ttggttacag acgagcatgc gctccattag ccagttggcg gggtaacggc 180
ccaccaaagc gacgatggat aggggttctg agaggaaggt cccccacatt ggaactgaga 240
cacggtccaa actcctacgg gaggcagcag tgaggaatat tggtcaatgg tcggcagact 300
gaaccagcca agtcgcgtga gggaagacgg cctacgggtt gtaaacctct tttgtcggag 360
agtatgcaag tatccgaaga aaaagcatcg gctaactccg tgccagcagc cgcggtaata 420
cggaggatgc gagcgttatc cggatttatt gggtttaaag ggtgcgtagg cggcacgcca 480
agtcagcggt gaaatttccg ggctcaaccc ggagtgtgcc gttgaaactg gcgagctaga 540
gtacacaaga ggcaggcgga atgcgtggtg tagcggtgaa atgcatagat atcacgcaga 600
accccgattg cgaaggcagc ctgctagggt gacagacgct gaggcacgaa agcgtgggta 660
tcgaacagga ttagataccc tggtagtcca cgcagtaaac gatgaatact aactgtttgc 720
gtgtaagcgg tacagcgaaa gcgttaagta ttccacctgg ggagtacgcc ggcaacggtg 780
aaactcaaag gaattgacgg gggcccgcac aagcggagga acatgtggtt taattcgatg 840
atacgcgagg aaccttaccc gggctcaaac gcgaggtgct gcatggttgt cgtcagctcg 900
tgccgtgagg tgtcggctta agtgccataa cgagcgcaac ccctatcgac agttactaac 960
ggccgaggac tctgtcgaga ctgccggcgc aagccggagg aaggtgggga tgacgtcaaa 1020
tcagcacggc ccttacgtcc ggggcgacac acgtgttaca atggcaggca gaaggcagcc 1080
agtcagcaat gacgcgcgaa tcccgcctgt ctcagttcgg atggagtctg caacccgact 1140
ccagaagctg gattcgctag taatcgcgca tcagccatgg cgcggtgaat acgttcccgg 1200
gccttgtaca caccgcccgt caagccatgg aagccgggag tacctgaagc atgcagcgta 1260
cgaaggtaat accggtaact ggggctaagt cgtaacaagg tagccgtacc ggaagg 1316
<210> 60
<211> 1536
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_adolescentis
<400> 60
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatcggctg gagcttgctc cggccgtgag agtggcgaac gggtgagtaa 120
tgcgtgaccg acctgcccca tacaccggaa tagctcctgg aaacgggtgg taatgccgga 180
tgctccagtt ggatgcatgt ccttctggga aagattctat cggtatggga tggggtcgcg 240
tcctatcagc ttgatggcgg ggtaacggcc caccatggct tcgacgggta gccggcctga 300
gagggcgacc ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatgacggc 420
cttcgggttg taaaccgctt ttgactggga gcaagccctt cggggtgagt gtacctttcg 480
aataagcacc ggctaactac gtgccagcag ccgcggtaat acgtagggtg caagcgttat 540
ccggaattat tgggcgtaaa gggctcgtag gcggttcgtc gcgtccgggt gtgaaagtcc 600
atcgcttaac ggtggatccg cgccgggtac gggcgggctt gagtgcggta ggggagactg 660
gaattcccgg tgtaacggtg gaatgtgtag atatcgggaa gaacaccaat ggcgaaggca 720
ggtctctggg ccgtcactga cgctgaggag cgaaagcgtg gggagcgaac aggattagat 780
accctggtag tccacgccgt aaacggtgga tgctggatgt ggggaccatt ccacggtctc 840
cgtgtcggag ccaacgcgtt aagcatcccg cctggggagt acggccgcaa ggctaaaact 900
caaagaaatt gacgggggcc cgcacaagcg gcggagcatg cggattaatt cgatgcaacg 960
cgaagaacct tacctgggct tgacatgttc ccgacagccg tagagatacg gtttcccttc 1020
ggggcgggtt cacaggtggt gcatggtcgt cgtcagctcg tgtcgtgaga tgttgggtta 1080
agccccgcaa cgagcgcaac cctcgccctg tgttgccagc acgtcgtggt gggaactcac 1140
gggggaccgc cggggtcaac tcggaggaag gtggggatga cgtcagatca tcatgcccct 1200
tacgtccagg gcttcacgca tgctacaatg gccggtacaa cgggatgcga caccgcgagg 1260
tggagcggat cccttaaaac cggtctcagt tcggattgga gtctgcaacc cgactccatg 1320
aaggcggagt cgctagtaat cgcggatcag caacgccgcg gtgaatgcgt tcccgggcct 1380
tgtacacacc gcccgtcaag tcatgaaagt gggtagcacc cgaagccggt ggcccaacct 1440
tttttggggg gagccgtcta aggtgagact cgtgattggg actaagtcgt aacaaggtag 1500
ccgtaccgga aggtgcggct ggatcacctc ctttct 1536
<210> 61
<211> 1438
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_adolescentis
<400> 61
aggacgctgg cggcgtgctt acacatgcag tcgaacggga tcccaggagc ttgctcctgg 60
gtgagagtgg cgaacgggtg agtaatgcgt gaccgacctg ccccatacac cggaatagct 120
cctggaaacg ggtggtaatg ccggatgctc cgacatgacg catgtcgtgt cgggaaagat 180
tcatcggtat gggatggggt cgcgtcctat cagcttgatg gcggggtaac ggcccaccat 240
ggcttcgacg ggtagccggc ctgagagggc gaccggccac attgggactg agatacggcc 300
cagactccta cgggaggcag cagtggggaa tattgcacaa tgggcgcaag cctgatgcag 360
cgacgccgcg tgcgggatga cggccttcgg gttgtaaacc gcttttgact gggagcaagc 420
ccttcggggt gagtgtacct ttcgaataag caccggctaa ctacgtgcca gcagccgcgg 480
taatacgtag ggtgcaagcg ttatccggaa ttattgggcg taaagggctc gtaggcggtt 540
cgtcgcgtcc ggtgtgaaag tccatcgctt aacggtggat ccgcgccggg tacgggcggg 600
cttgagtgcg gtaggggaga ctggaattcc cggtgtaacg gtggaatgtg tagatatcgg 660
gaagaacacc aatggcgaag gcaggtctct gggccgtcac tgacgctgag gagcgaaagc 720
gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacggt ggatgctgga 780
tgtggggacc attccacggt ctccgtgtcg gagccaacgc gttaagcatc ccgcctgggg 840
agtacggccg caaggctaaa actcaaagaa attgacgggg gcccgcacaa gcggcggagc 900
atgcggatta attcgatgca acgcgaagaa ccttacctgg gcttgacatg ttcccgacag 960
ccccagagat ggggcctccc ttcggggcgg gttcacaggt ggtgcatggt cgtcgtcagc 1020
tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aaccctcgcc ctgtgttgcc 1080
agcacgtcgt ggtgggaact cacgggggac cgccggggtc aactcggagg aaggtgggga 1140
tgacgtcaga tcatcatgcc ccttacgtcc agggcttcac gcatgctaca atggccggta 1200
caacgggatg cgacaccgcg aggtggagcg gatcccttaa aaccggtctc agttcggatt 1260
ggagtctgca acccgactcc atgaaggcgg agtcgctagt aatcgcggat cagcaacgcc 1320
gcggtgaatg cgttcccggg ccttgtacac accgcccgtc aagtcatgaa agtgggtagc 1380
acccgaagcc ggtggcccaa ccttttgggg ggagccgtct aagggagact ccgatggc 1438
<210> 62
<211> 1536
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_adolescentis
<400> 62
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatcccagg agcttgctcc tgggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ctccagttgg atgcatgtcc ttctgggaaa gattcatcgg tatgggatgg ggtcgcgtcc 240
tatcagcttg atggcggggt aacggcccac catggcttcg acgggtagcc ggcctgagag 300
ggcgaccggc cacattggga ctgagatacg gcccagactc ctacgggagg cagcagtggg 360
gaatattgca caatgggcgc aagcctgatg cagcgacgcc gcgtgcggga tgacggcctt 420
cgggttgtaa accgcttttg actgggagca agcccttcgg ggtgagtgta cctttcgaat 480
aagcaccggc taactacgtg ccagcagccg cggtaatacg tagggtgcaa gcgttatccg 540
gaattattgg gcgtaaaggg ctcgtaggcg gttcgtcgcg tccggtgtga aagtccatcg 600
cttaacggtg gatccgcgcc gggtacgggc gggcttgagt gcggtagggg agactggaat 660
tcccggtgta acggtggaat gtgtagatat cgggaagaac accaatggcg aaggcaggtc 720
tctgggccgt cactgacgct gaggagcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg accattccac ggtctccgtg 840
tcggagccaa cgcgttaagc atcccgcctg gggagtacgg ccgcaaggct aaaactcaaa 900
gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa 960
gaaccttacc tgggcttgac atgttcccga cagccgtaga gatacggtct cccttcgggg 1020
cgggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctc gccctgtgtt gccagcacgt cgtggtggga actcacgggg 1140
gaccgccggg gtcaactcgg aggaaggtgg ggatgacgtc agatcatcat gccccttacg 1200
tccagggctt cacgcatgct acaatggccg gtacaacggg atgcgacacc gcgaggtgga 1260
gcggatccct taaaaccggt ctcagttcgg attggagtct gcaacccgac tccatgaagg 1320
cggagtcgct agtaatcgcg gatcagcaac gccgcggtga atgcgttccc gggccttgta 1380
cacaccgccc gtcaagtcat gaaagtgggt agcacccgaa gccggtggcc caaccttttg 1440
gggggagccg tctaaggtga gactcgtgat tgggactaag tcgtaacaag gtagccgtac 1500
cggaaggtgc ggctggatca cctcctttct acggag 1536
<210> 63
<211> 1295
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_adolescentis
<400> 63
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gagtggcgaa cgggtgagta 60
atgcgtgacc gacctgcccc atacaccgga atagctcctg gaaacgggtg gtaatgccgg 120
atgctgaaag tcggtatggg atggggtcgc gtcctatcag cttgatggcg gggtaacggc 180
ccaccatggc ttcgacgggt agccggcctg agagggcgac cggccacatt gggactgaga 240
tacggcccag actcctacgg gaggcagcag tggggaatat tgcacaatgg gcgcaagcct 300
gatgcagcga cgccgcgtgc gggatgacgg ccttcgggtt gtaaaccgct tttgactggg 360
agcatgagtg tacctttcga ataagcaccg gctaactacg tgccagcagc cgcggtaata 420
cgtagggtgc aagcgttatc cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg 480
cgtccggtgt gaaagtccat cgcttaacgg tggatccgcg ccgggtacgg gcgggcttga 540
gtgcggtagg ggagactgga attcccggtg taacggtgga atgtgtagat atcgggaaga 600
acaccaatgg cgaaggcagg tctctgggcc gactgacgct gaggagcgaa agcgtgggga 660
gcgaacagga ttagataccc tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg 720
atctccgtgt cggagccaac gcgttaagca tcccgcctgg ggagtacggc cgcaaggcta 780
aaactcaaag aaattgacgg gggcccgcac aagcggcgga gcatgcggat taattcgatg 840
caacgcgaag aaccttacct gggcttgaca tgcacaggtg gtgcatggtc gtcgtcagct 900
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca accctcgccc tgtgttgcca 960
gcacgtggga actcacgggg gaccgccggg gtcaactcgg aggaaggtgg ggatgacgtc 1020
agatcatcat gccccttacg tccagggctt cacgcatgct acaatggccg gcaacgggat 1080
gcgacaccgc gaggtggagc ggatcccttc cggtctcagt tcggatggag tctgcaaccc 1140
gactccagaa ggcggagtcg ctagtaatcg cggatcagca acgccgcggt gaatgcgttc 1200
ccgggccttg tacacaccgc ccgtcaagtc atgaaagtgg gtagcacccg aagccggtgc 1260
ccagggagcc gtctaaggtg agactcgtga ttggg 1295
<210> 64
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_angulatum
<400> 64
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatcggctg gagcttgctc cggccgtgag agtggcgaac gggtgagtaa 120
tgcgtgaccg acctgccccg tacaccggaa tagctcctgg aaacgggtgg taatgccgga 180
tgctccagtc catcgcatgg tggtctggga aagattttat cggtatggga tggggtcgcg 240
tcctatcagg tagtcggcgg ggtaacggcc caccgagcct acgacgggta gccggcctga 300
gagggcgacc ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatgacggc 420
cttcgggttg taaaccgctt ttgttgggga gcaagccttc gggtgagtgt acccttcgaa 480
taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgca agcgttatcc 540
ggaattattg ggcgtaaaga gctcgtaggc ggttcgtcgc gtccggtgtg aaagtccatc 600
gcttaacggt ggatctgcgc cgggtacggg cgggctggag tgcggtaggg gagactggaa 660
ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc gaaggcaggt 720
ctctgggccg ttactgacgc tgaggagcga aagcgtgggg agcgaacagg attagatacc 780
ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gcccattcca cgggttccgt 840
gtcggagcta acgcgttaag catcccgcct ggggagtacg gccgcaaggc taaaactcaa 900
agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga tgcaacgcga 960
agaaccttac ctgggcttga catgttcccg acagccccag agatggggcc tcccttcggg 1020
gcgggttcac aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct cgccccgtgt tgccagcaca tgatggtggg aactcacggg 1140
ggaccgccgg ggttaactcg gaggaaggtg gggatgacgt cagatcatca tgccccttac 1200
gtccagggct tcacgcatgc tacaatggcc ggtacaacgg gatgcgacat ggcgacatgg 1260
agcggatccc tgaaaaccgg tctcagttcg gattggagtc tgcaacccga ctccatgaag 1320
gcggagtcgc tagtaatcgc gaatcagcaa cgtcgcggtg aatgcgttcc cgggccttgt 1380
acacaccgcc cgtcaagtca tgaaagtggg tagcacccga agccggtggc ccaaccagtt 1440
cgctgggggg agccgtctaa ggtgagactc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttct 1535
<210> 65
<211> 1307
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_angulatum
<400> 65
gagagtttgg acctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgggatccga caagcttgct tgtcggtgag agtggcgaac gggtgagtaa tgcgtgaccg 120
acctgcccca tacaccggaa tagctcctgg aaacgggtgg taatgccgga tgctccagtc 180
catcgcatgg tggtctggga aagatttcat cggtatggga tggggtcgcg tcctatcagg 240
tagtcggcgg ggtaacggcc caccgagcct acgacgggta gccggcctga gagggcgacc 300
ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt ggggaatatt 360
gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatgacggc cttcgggttg 420
taaaccgctt ttgatcggga gcaagccttc gggtgagtta cctcgaataa gcaccggcta 480
actacgtgcc agcagccgcg gtaatacgta gggtgcaagc gttatccgga attattgggc 540
gtaaaggggt ggtaggcggt tcgtcgcgtc cggtgtgaaa gtccatcgct taacggtgga 600
tccgccccgg gtacgggcgg gcttgagtgc ggtaggggag actggaattc ccggtgtaac 660
ggtggaatgt gtagatatcg ggaagaacac caatggcgaa ggcaggtctc tgggccgtcc 720
ctgacgatga ggagagaaag cgtggggagg gaacaagatt agataccctg gtagttcccc 780
ccgtaaacgg tggatgctgg atgtggggcc cattccacgg gttcagtgtc ggagctaacg 840
cgtaagctcg ccgcctggga gacgcccgca aggctaaaac tcaaagaaat tgacgggggc 900
ccgcacaagc ggcggagcat gcggattaat tcgatgcaac gcgaagaacc ttacctgggc 960
ttgacatgtt cccgacagcc ccagagatgg ggcctccctt cggggcgggt tcacaggtgg 1020
tgcatggtcg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 1080
ccctcgccct gtgttgccag cacgtcatgg tgggaactca cgggggaccg ccggggtcaa 1140
ctcggaggaa ggtggggatg acgtcagatc atcatgcccc ttacgtccag ggcttcacgc 1200
atgctacaat ggccggtaca acgggatgcg acatggcgac atggagcgga tcccttaaaa 1260
ccggtctcag ttcggattgg agtctgcaac ccgactccat gaagtcg 1307
<210> 66
<211> 1313
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 66
gtcggggtga gagtggcgaa cgggtgagta atgcgtgacc aacctgccct gtgcaccgga 60
atagctccag gaaacgggtg gtaataccgg atgctccgct ccatcgcatg ggtggggtgg 120
gaaatgcttt tgcggcatgg gatggggtcg cgtcctatca gcttgttggc ggggtgatgg 180
cccaccaagg cgttgacggg tagccggcct gagagggtga ccggccacat tgggactgag 240
atacggccca gactcctacg ggaggcagca gtggggaata ttgcacaatg ggcgcaagcc 300
tgatgcagcg acgccgcgtg cgggatggag gccttcgggt tgtaaaccgc ttttgttcaa 360
gggcaaggca cggtttcggc cgtgttgagt ggattgttcg aataagcacc ggctaactac 420
gtgccagcag ccgcggtaat acgtagggtg cgagcgttat ccggatttat tgggcgtaaa 480
gggctcgtag gcggttcgtc gcgtccggtg tgaaagtcca tcgcctaacg gtggatctgc 540
gccgggtacg ggcgggctgg agtgcggtag gggagactgg aattcccggt gtaacggtgg 600
aatggcgggc tggagtgcgg taggggagac tggaattccc ggtgtaacgg tggaatgtgt 660
agatatcggg aagaacacca atggcgaagg caggtctctg ggccgtcact gacgctgagg 720
agcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc gtaaacggtg 780
gatgctggat gtggggccct ttccacgggt cccgtgtcgg agccaacgcg ttaagcatcc 840
cgcctgggga gtacggccgc aaggctaaaa ctcaaagaaa ttgacggggg cccgcacaag 900
cggcggagca tgcggattaa ttcgatgcaa cgcgaagaac cttacctggg cttgacatgt 960
gccggatcgc cgtggagaca cggtttccct tcggggccgg ttcacaggtg gtgcatggtc 1020
gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca accctcgccg 1080
catgttgcca gcgggtgatg ccgggaactc atgtgggacc gccggggtca actcggagga 1140
aggaggggat gacgtcagat catcatgccc cttacgtcca gggcttcacg catgcttcaa 1200
tggccggtac aacgcggtgc gacacggtga cgtggggcgg atcgctgaaa accggtctca 1260
gttcggatcg cagtctgcaa ctcgactgcg tgaaggcgga gtcgctagta atc 1313
<210> 67
<211> 1394
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 67
caagtcgaac gggatccctg gcagcttgct gtcggggtga gagtggcgaa cgggtgagta 60
atgcgtgacc aacctgccct gtgcaccgga atagctcctg gaaacgggtg gtaataccgg 120
atgctccgct ccatcgcatg gtggggtggg aaatgctttt gcggcatggg atggggtcgc 180
gtcctatcag cttgttggcg gggtgatggc ccaccaaggc gttgacgggt agccggcctg 240
agagggtgac cggccacatt gggactgaga tacggcccag actcctacgg gaggcagcag 300
tggggaatat tgcacaatgg gcgcaagcct gatgcagcga cgccgcgtgc gggatggagg 360
ccttcgggtt gtaaaccgct tttgttcaag ggcaaggcac ggtttcggcc gtgttgagtg 420
gattgttcga ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc 480
gagcgttatc cggatttatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt 540
gaaagtccat cgcctaacgg tggatctgcg ccgggtacgg gcgggctgga gtgcggtagg 600
ggagactgga attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg 660
cgaaggcagg tctctgggcc gtcactgacg ctgaggagcg aaagcgtggg gagcgaacag 720
gattagatac cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggccctttcc 780
acgggtcccg tgtcggagcc aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg 840
ctaaaactca aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg 900
atgcaacgcg aagaacctta cctgggcttg acatgtgccg gatcgccgtg gagacacggt 960
ttcccttcgg ggccggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg 1020
ttgggttaag tcccgcaacg agcgcaaccc tcgccgcatg ttgccagcgg gtgatgccgg 1080
gaactcatgt gggaccgccg gggtcaactc ggaggaaggt ggggatgacg tcagatcatc 1140
atgcccctta cgtccagggc ttcacgcatg ctacaatggc cggtacaacg cggtgcgaca 1200
cggtgacgtg gggcggatcg ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg 1260
actgcgtgaa ggcggagtcg ctagtaatcg cggatcagca acgccgcggt gaatgcgttc 1320
ccgggccttg tacacaccgc ccgtcaagtc atgaaagtgg gtagcacccg aagccggtgg 1380
cccgaccctt gtgg 1394
<210> 68
<211> 1541
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 68
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccctgg cagcttgctg tcggggtgag agtggcgaac gggtgagtaa 120
tgcgtgacca acctgccctg tgcaccggaa tagctcctgg aaacgggtgg taataccgga 180
tgctccgctc catcgcatgg tggggtggga aatgcttttg cggcatggga tggggtcgcg 240
tcctatcagc ttgttggcgg ggtgatggcc caccaaggcg ttgacgggta gccggcctga 300
gagggtgacc ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatggaggc 420
cttcgggttg taaaccgctt ttgttcaagg gcaaggcacg gtttcggccg tgttgagtgg 480
attgttcgaa taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgcg 540
agcgttatcc ggatttattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg 600
aaagtccatc gcctaacggt ggatctgcgc cgggtacggg cgggctggag tgcggtaggg 660
gagactggaa ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc 720
gaaggcaggt ctctgggccg tcactgacgc tgaggagcga aagcgtgggg agcgaacagg 780
attagatacc ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gccctttcca 840
cgggtcccgt gtcggagcca acgcgttaag catcccgcct ggggagtacg gccgcaaggc 900
taaaactcaa agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga 960
tgcaacgcga agaaccttac ctgggcttga catgtgccgg atcgccgtgg agacacggtt 1020
tcccttcggg ccggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt 1080
gggttaagtc ccgcaacgag cgcaaccctc gccgcatgtt gccagcgggt gatgccggga 1140
actcatgtgg gaccgccggg gtcaactcgg aggaaggtgg ggatgacgtc agatcatcat 1200
gccccttacg tccagggctt cacgcatgct acaatggccg gtacaacgcg gtgcgacacg 1260
gtgacgtggg gcggatcgct gaaaaccggt ctcagttcgg atcgcagtct gcaactcgac 1320
tgcgtgaagg cggagtcgct agtaatcgcg gatcagcaac gccgcggtga atgcgttccc 1380
gggccttgta cacaccgccc gtcaagtcat gaaagtgggt agcacccgaa gccggtggcc 1440
cgacccttgt ggggggagcc gtctaaggtg agactcgtga ttgggactaa gtcgtaacaa 1500
ggtagccgta ccggaaggtg cggctggatc acctcctttc t 1541
<210> 69
<211> 1453
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 69
gaacgctggc ggcgtgctta acacatgcaa gtcgaacggg atccctggca gcttgctgtc 60
ggggtgagag tggcgaacgg gtgagtaatg cgtgaccaac ctgccctgtg caccggaata 120
gctcctggaa acgggtggta ataccggatg ctccgctcca tcgcatggtg gggtgggaaa 180
tgcttttgcg gcatgggatg gggtcgcgtc ctatcagctt gttggcgggg tgatggccca 240
ccaaggcgtt gacgggtagc cggcctgaga gggtgacccg gccacattgg gactgagata 300
cggcccagac tcctacggga ggcagcagtg gggaatattg cacaatgggc gcaagcctga 360
tgcagcgacg ccgcgtgcgg gatggaggcc ttcgggttgt aaaccgcttt tgttcaaggg 420
caaggcacgg tttcggccgt gttgagtgga ttgttcgaat aagcaccggc taactacgtg 480
ccagcagccg cggtaatacg tagggtgcga gcgttatccg gatttattgg gcgtaaaggg 540
ctcgtaggcg gttcgtcgcg tccggtgtga aagtccatcg cctaacggtg gatctgcgcc 600
gggtacgggc gggctggagt gcggtagggg agactggaat tcccggtgta acggtggaat 660
gtgtagatat cgggaagaac accaatggcg aaggcaggtc tctgggccgt cactgacgct 720
gaggagcgaa agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac 780
ggtggatgct ggatgtgggg ccctttccac gggtcccgtg tcggagccaa cgcgttaagc 840
atcccgcctg gggagtacgg ccgcaaggct aaaactcaaa gaaattgacg ggggcccgca 900
caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa gaaccttacc tgggcttgac 960
atgtgccgga tcgccgtgga gacacggttt cccttcgggg ccggttcaca ggtggtgcat 1020
ggtcgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctc 1080
gccgcatgtt gccagcgggt gatgccggga actcatgtgg gaccgccggg gtcaactcgg 1140
aggaaggtgg ggatgacgtc agatcatcat gccccttacg tccagggctt cacgcatgct 1200
acaatggccg gtacaacgcg gtgcgacacg gtgacgtggg gcggatcgct gaaaaccggt 1260
ctcagttcgg atcgcagtct gcaactcgac tgcgtgaagg cggagtcgct agtaatcgcg 1320
gatcagcaac gccgcggtga atgcgttccc gggccttgta cacaccgccc gtcaagtcat 1380
gaaagtgggt agcacccgaa gccggtggcc cgacccttgt ggggggagcc gtctaaggtg 1440
agactcgtga ttg 1453
<210> 70
<211> 1526
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 70
tcgattctgg ctcaggatga acgctggcgg cgtgcttaac acatgcaagt cgaacgggat 60
ccctggcagc ttgctgtcgg ggtgagagtg gcgaacgggt gagtaatgcg tgaccaacct 120
gccctgtgca ccggaatagc tcctggaaac gggtggtaat accggatgct ccgctccatc 180
gcatggtggg gtgggaaatg cttttgcggc atgggatggg gtcgcgtcct atcagcttgt 240
tggcggggtg atggcccacc aaggcgttga cgggtagccg gcctgagagg gtgaccggcc 300
acattgggac tgagatacgg cccagactcc tacgggaggc agcagtgggg aatattgcac 360
aatgggcgca agcctgatgc agcgacgccg cgtgcgggat ggaggccttc gggttgtaaa 420
ccgcttttgt tcaagggcaa ggcacggttt cggccgtgtt gagtggattg ttcgaataag 480
caccggctaa ctacgtgcca gcagccgcgg taatacgtag ggtgcgagcg ttatccggat 540
ttattgggcg taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgcct 600
aacggtggat ctgcgccggg tacgggcggg ctggagtgcg gtaggggaga ctggaattcc 660
cggtgtaacg gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct 720
gggccgtcac tgacgctgag gagcgaaagc gtggggagcg aacaggatta gataccctgg 780
tagtccacgc cgtaaacggt ggatgctgga tgtggggccc tttccacggg tcccgtgtcg 840
gagccaacgc gttaagcatc ccgcctgggg agtacggccg caaggctaaa actcaaagaa 900
attgacgggg gcccgcacaa gcggcggagc atgcggatta attcgatgca acgcgaagaa 960
ccttacctgg gcttgacatg tgccggatcg ccgtggagac acggtttccc ttcggggccg 1020
gttcacaggt ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aaccctcgcc gcatgttgcc agcgggtgat gccgggaact catgtgggac 1140
cgccggggtc aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc 1200
agggcttcac gcatgctaca atggccggta caacgcggtg cgacacggtg acgtggggcg 1260
gatcgctgaa aaccggtctc agttcggatc gcagtctgca actcgactgc gtgaaggcgg 1320
agtcgctagt aatcgcggat cagcaacgcc gcggtgaatg cgttcccggg ccttgtacac 1380
accgcccgtc aagtcatgaa agtgggtagc acccgaagcc ggtggcccga cccttgtggg 1440
gggagccgtc taaggtgaga ctcgtgattg ggactaagtc gtaacaaggt agccgtaccg 1500
gaaggtgcgg ctggatcacc tccttt 1526
<210> 71
<211> 1549
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 71
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccctgg cagcttgctg tcggggtgag agtggcgaac gggtgagtaa 120
tgcgtgacca acctgccctg tgcaccggaa tagctcctgg aaacgggtgg taataccgga 180
tgctccgctc catcgcatgg tggggtggga aatgcttttg cggcatggga tggggtcgcg 240
tcctatcagc ttgttggcgg ggtgatggcc caccaaggcg ttgacgggta gccggcctga 300
gagggtgacc ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatggaggc 420
cttcgggttg taaaccgctt ttgttcaagg gcaaggcacg gtttcggccg tgttgagtgg 480
attgttcgaa taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgcg 540
agcgttatcc ggatttattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg 600
aaagtccatc gcctaacggt ggatctgcgc cgggtacggg cgggctggag tgcggtaggg 660
gagactggaa ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc 720
gaaggcaggt ctctgggccg tcactgacgc tgaggagcga aagcgtgggg agcgaacagg 780
attagatacc ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gccctttcca 840
cgggtcccgt gtcggagcca acgcgttaag catcccgcct ggggagtacg gccgcaaggc 900
taaaactcaa agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga 960
tgcaacgcga agaaccttac ctgggcttga catgtgccgg atcgccgtgg agacacggtt 1020
tcccttcggg gccggttcac aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt 1080
tgggttaagt cccgcaacga gcgcaaccct cgccgcatgt tgccagcggg tgatgccggg 1140
aactcatgtg ggaccgccgg ggtcaactcg gaggaaggtg gggatgacgt cagatcatca 1200
tgccccttac gtccagggct tcacgcatgc tacaatggcc ggtacaacgc ggtgcgacac 1260
ggtgacgtgg ggcggatcgc tgaaaaccgg tctcagttcg gatcgcagtc tgcaactcga 1320
ctgcgtgaag gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc 1380
cgggccttgt acacaccgcc cgtcaagtca tgaaagtggg tagcacccga agccggtggc 1440
ccgacccttg tggggggagc cgtctaaggt gagactcgtg attgggacta agtcgtaaca 1500
aggtagccgt accggaaggt gcggctggat cacctccttt ctacggaga 1549
<210> 72
<211> 1530
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 72
agggttcgat tctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gggatccctg gcagcttgct gtcggggtga gagtggcgaa cgggtgagta atgcgtgacc 120
aacctgccct gtgcaccgga atagctcctg gaaacgggtg gtaataccgg atgctccgct 180
ccatcgcatg gtggggtggg aaatgctttt gcggcatggg atggggtcgc gtcctatcag 240
cttgttggcg gggtgatggc ccaccaaggc gttgacgggt agccggcctg agagggtgac 300
cggccacatt gggactgaga tacggcccag actcctacgg gaggcagcag tggggaatat 360
tgcacaatgg gcgcaagcct gatgcagcga cgccgcgtgc gggatggagg ccttcgggtt 420
gtaaaccgct tttgttcaag ggcaaggcac ggtttcggcc gtgttgagtg gattgttcga 480
ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc gagcgttatc 540
cggatttatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt gaaagtccat 600
cgcctaacgg tggatctgcg ccgggtacgg gcgggctgga gtgcggtagg ggagactgga 660
attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg cgaaggcagg 720
tctctgggcc gtcactgacg ctgaggagcg aaagcgtggg gagcgaacag gattagatac 780
cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggccctttcc acgggtcccg 840
tgtcggagcc aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca 900
aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg 960
aagaacctta cctgggcttg acatgtgccg gatcgccgtg gagacacggt ttcccttcgg 1020
ggccggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag 1080
tcccgcaacg agcgcaaccc tcgccgcatg ttgccagcgg gtgatgccgg gaactcatgt 1140
gggaccgccg gggtcaactc ggaggaaggt ggggatgacg tcagatcatc atgcccctta 1200
cgtccagggc ttcacgcatg ctacaatggc cggtacaacg cggtgcgaca cggtgacgtg 1260
gggcggatcg ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa 1320
ggcggagtcg ctagtaatcg cggatcagca acgccgcggt gaatgcgttc ccgggccttg 1380
tacacaccgc ccgtcaagtc atgaaagtgg gtagcacccg aagccggtgg cccgaccctt 1440
gtggggggag ccgtctaagg tgagactcgt gattgggact aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga tcacctcctt 1530
<210> 73
<211> 1550
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 73
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccctgg cagcttgctg tcggggtgag agtggcgaac gggtgagtaa 120
tgcgtgacca acctgccctg tgcaccggaa tagctcctgg aaacgggtgg taataccgga 180
tgctccgctc catcgcatgg tggggtggga aatgcttttg cggcatggga tggggtcgcg 240
tcctatcagc ttgttggcgg ggtgatggcc caccaaggcg ttgacgggta gccggcctga 300
gagggtgacc ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatggaggc 420
cttcgggttg taaaccgctt ttgttcaagg gcaaggcacg gtttcggccg tgttgagtgg 480
attgttcgaa taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgcg 540
agcgttatcc ggatttattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg 600
aaagtccatc gcctaacggt ggatctgcgc ccgggtacgg gcgggctgga gtgcggtagg 660
ggagactgga attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg 720
cgaaggcagg tctctgggcc gtcactgacg ctgaggagcg aaagcgtggg gagcgaacag 780
gattagatac cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggccctttcc 840
acgggtcccg tgtcggagcc aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg 900
ctaaaactca aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg 960
atgcaacgcg aagaacctta cctgggcttg acatgtgccg gatcgccgtg gagacacggt 1020
ttcccttcgg ggccggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg 1080
ttgggttaag tcccgcaacg agcgcaaccc tcgccgcatg ttgccagcgg gtgatgccgg 1140
gaactcatgt gggaccgccg gggtcaactc ggaggaaggt ggggatgacg tcagatcatc 1200
atgcccctta cgtccagggc ttcacgcatg ctacaatggc cggtacaacg cggtgcgaca 1260
cggtgacgtg gggcggatcg ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg 1320
actgcgtgaa ggcggagtcg ctagtaatcg cggatcagca acgccgcggt gaatgcgttc 1380
ccgggccttg tacacaccgc ccgtcaagtc atgaaagtgg gtagcacccg aagccggtgg 1440
cccgaccctt gtggggggag ccgtctaagg tgagactcgt gattgggact aagtcgtaac 1500
aaggtagccg taccggaagg tgcggctgga tcacctcctt tctacggaga 1550
<210> 74
<211> 1466
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 74
tctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gggatccctg 60
gcagcttgct gtcggggtga gagtggcgaa cgggtgagta atgcgtgacc aacctgccct 120
gtgcaccgga atagctcctg gaaacgggtg gtaataccgg atgctccgct ccatcgcatg 180
gtggggtggg aaatgctttt gcggcatggg atggggtcgc gtcctatcag cttgttggcg 240
gggtgatggc ccaccaaggc gttgacgggt agccggcctg agagggtgac cggccacatt 300
gggactgaga tacggcccag actcctacgg gaggcagcag tggggaatat tgcacaatgg 360
gcgcaagcct gatgcagcga cgccgcgtgc gggatggagg ccttcgggtt gtaaaccgct 420
tttgttcaag ggcaaggcac ggtttcggcc gtgttgagtg gattgttcga ataagcaccg 480
gctaactacg tgccagcagc cgcggtaata cgtagggtgc gagcgttatc cggatttatt 540
gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt gaaagtccat cgcctaacgg 600
tggatctgcg ccgggtacgg gcgggctgga gtgcggtagg ggagactgga attcccggtg 660
taacggtgga atgtgtagat atcgggaaga acaccaatgg cgaaggcagg tctctgggcc 720
gtcactgacg ctgaggagcg aaagcgtggg gagcgaacag gattagatac cctggtagtc 780
cacgccgtaa acggtggatg ctggatgtgg ggccctttcc acgggtcccg tgtcggagcc 840
aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca aagaaattga 900
cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg aagaacctta 960
cctgggcttg acatgtgccg gatcgccgtg gagacacggt ttcccttcgg ggccggttca 1020
caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1080
agcgcaaccc tcgccgcatg ttgccagcgg gtgatgccgg gaactcatgt gggaccgccg 1140
gggtcaactc ggaggaaggt ggggatgacg tcagatcatc atgcccctta cgtccagggc 1200
ttcacgcatg ctacaatggc cggtacaacg cggtgcgaca cggtgacgtg gggcggatcg 1260
ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa ggcggagtcg 1320
ctagtaatcg cggatcagca acgccgcggt gaatgcgttc ccgggccttg tacacaccgc 1380
ccgtcaagtc atgaaagtgg gtagcacccg aagccggtgg cccgaccctt gtggggggag 1440
ccgtctaagg tgagactcgt gattgg 1466
<210> 75
<211> 1542
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 75
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccctgg cagcttgctg tcggggtgag agtggcgaac gggtgagtaa 120
tgcgtgacca acctgccctg tgcaccggaa tagctcctgg aaacgggtgg taataccgga 180
tgctccgctc catcgcatgg tggggtggga aatgcttttg cggcatggga tggggtcgcg 240
tcctatcagc ttgttggcgg ggtgatggcc caccaaggcg ttgacgggta gccggcctga 300
gagggtgacc ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatggaggc 420
cttcgggttg taaaccgctt ttgttcaagg gcaaggcacg gtttcggccg tgttgagtgg 480
attgttcgaa taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgcg 540
agcgttatcc ggatttattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg 600
aaagtccatc gcctaacggt ggatctgcgc cgggtacggg cgggctggag tgcggtaggg 660
gagactggaa ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc 720
gaaggcaggt ctctgggccg tcactgacgc tgaggagcga aagcgtgggg agcgaacagg 780
attagatacc ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gccctttcca 840
cgggtcccgt gtcggagcca acgcgttaag catcccgcct ggggagtacg gccgcaaggc 900
taaaactcaa agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga 960
tgcaacgcga agaaccttac ctgggcttga catgtgccgg atcgccgtgg agacacggtt 1020
tcccttcggg gccggttcac aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt 1080
tgggttaagt cccgcaacga gcgcaaccct cgccgcatgt tgccagcggg tgatgccggg 1140
aactcatgtg ggaccgccgg ggtcaactcg gaggaaggtg gggatgacgt cagatcatca 1200
tgccccttac gtccagggct tcacgcatgc tacaatggcc ggtacaacgc ggtgcgacac 1260
ggtgacgtgg ggcggatcgc tgaaaaccgg tctcagttcg gatcgcagtc tgcaactcga 1320
ctgcgtgaag gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc 1380
cgggccttgt acacaccgcc cgtcaagtca tgaaagtggg tagcacccga agccggtggc 1440
ccgacccttg tggggggagc cgtctaaggt gagactcgtg attgggacta agtcgtaaca 1500
aggtagccgt accggaaggt gcggctggat cacctccttt ct 1542
<210> 76
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_animalis
<400> 76
agtttgatca tggctcagga tgaacgctgg cggcgtgctt aacacatgca agtcgaacgg 60
gatccctggc agcttgctgt cggggtgaga gtggcgaacg ggtgagtaat gcgtgaccaa 120
cctgccctgt gcaccggaat agctcctgga aacgggtggt aataccggat gctccgctcc 180
atcgcatggt ggggtgggaa atgcttttgc ggcatgggat ggggtcgcgt cctatcagct 240
tgttggcggg gtgatggccc accaaggcgt tgacgggtag ccggcctgag agggtgaccg 300
gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg gggaatattg 360
cacaatgggc gcaagcctga tgcagcgacg ccgcgtgcgg gatggaggcc ttcgggttgt 420
aaaccgcttt tgttcaaggg caaggcacgg tttcggccgt gttgagtgga ttgttcgaat 480
aagcaccggc taactacgtg ccagcagccg cggtaatacg tagggtgcga gcgttatccg 540
gatttattgg gcgtaaaggg ctcgtaggcg gttcgtcgcg tccggtgtga aagtccatcg 600
cctaacggtg gatctgcgcc gggtacgggc gggctggagt gcggtagggg agactggaat 660
tcccggtgta acggtggaat gtgtagatat cgggaagaac accaatggcg aaggcaggtc 720
tctgggccgt cactgacgct gaggagcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg ccctttccac gggtcccgtg 840
tcggagccaa cgcgttaagc atcccgcctg gggagtacgg ccgcaaggct aaaactcaaa 900
gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa 960
gaaccttacc tgggcttgac atgtgccgga tcgccgtgga gacacggttt cccttcgggg 1020
ccggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctc gccgcatgtt gccagcgggt gatgccggga actcatgtgg 1140
gaccgccggg gtcaactcgg aggaaggtgg ggatgacgtc agatcatcat gccccttacg 1200
tccagggctt cacgcatgct acaatggccg gtacaacgcg gtgcgacacg gtgacgtggg 1260
gcggatcgct gaaaaccggt ctcagttcgg atcgcagtct gcaactcgac tgcgtgaagg 1320
cggagtcgct agtaatcgcg gatcagcaac gccgcggtga atgcgttccc gggccttgta 1380
cacaccgccc gtcaagtcat gaaagtgggt agcacccgaa gccggtggcc cgacccttgt 1440
ggggggagcc gtctaaggtg agactcgtga ttgggactaa gtcgtaacaa ggtagccgta 1500
ccggaaggtg cggctggatc acctcctt 1528
<210> 77
<211> 1412
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_bifidum
<400> 77
cagtcgaacg ggatccatcg ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 60
gcgtgaccga cctgccccat gctccggaat agctcctgga aacgggtggt aatgccggat 120
gttccacatg atcgcatgtg attgtgggaa agattctatc ggcgtgggat ggggtcgcgt 180
cctatcagct tgttggtgag gtaacggctc accaaggctt cgacgggtag ccggcctgag 240
agggcgaccg gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg 300
gggaatattg cacaatgggc gcaagcctga tgcagcgacg ccgcgtgagg gatggaggcc 360
ttcgggttgt aaacctcttt tgtttgggag caagccttcg ggtgagtgta cctttcgaat 420
aagcgccggc taactacgtg ccagcagccg cggtaatacg tagggcgcaa gcgttatccg 480
gatttattgg gcgtaaaggg ctcgtaggcg gctcgtcgcg tccggtgtga aagtccatcg 540
cttaacggtg gatctgcgcc gggtacgggc gggctggagt gcggtagggg agactggaat 600
tcccggtgta acggtggaat gtgtagatat cgggaagaac accgatggcg aaggcaggtc 660
tctgggccgt cactgacgct gaggagcgaa agcgtgggga gcgaacagga ttagataccc 720
tggtagtcca cgccgtaaac ggtggacgct ggatgtgggg cacgttccac gtgttccgtg 780
tcggagctaa cgcgttaagc gtcccgcctg gggagtacgg ccgcaaggct aaaactcaaa 840
gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa 900
gaaccttacc tgggcttgac atgttcccga cgacgccaga gatggcgttt cccttcgggg 960
cgggttcaca ggtggtgcat ggtccgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1020
cccgcaacga gcgcaaccct cgccccgtgt tgccagcacg ttatggtggg aactcacggg 1080
ggaccgccgg ggttaactcg gaggaaggtg gggatgacgt cagatcatca tgccccttac 1140
gtccagggct tcacgcatgc tacaatggcc ggtacagcgg gatgcgacat ggcgacatgg 1200
agcggatccc tgaaaaccgg tctcagttcg gatcggagcc tgcaacccgg ctccgtgaag 1260
gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc cgggccttgt 1320
acacaccgcc cgtcaagtca tgaaagtggg cagcacccga agccggtggc ctaacccctt 1380
gtgggatgga gccgtctaag gtgaggctcg tg 1412
<210> 78
<211> 1488
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_bifidum
<400> 78
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gggatccatc aagcttgctt 60
ggtggtgaga gtggcgaacg ggtgagtaat gcgtgaccga cctgccccat gctccggaat 120
agctcctgga aacgggtggt aatgccggat gttccacatg atcgcatgtg attgtgggaa 180
agattctatc ggcgtgggat ggggtcgcgt cctatcagct tgttggtgag gtaacggctc 240
accaaggctt cgacgggtag ccggcctgag agggcgaccg gccacattgg gactgagata 300
cggcccagac tcctacggga ggcagcagtg gggaatattg cacaatgggc gcaagcctga 360
tgcagcgacg ccgcgtgagg gatggaggcc ttcgggttgt aaacctcttt tgtttgggag 420
caagccttcg ggtgagtgta cctttcgaat aagcgccggc taactacgtg ccagcagccg 480
cggtaatacg tagggcgcaa gcgttatccg gatttattgg gcgtaaaggg ctcgtaggcg 540
gctcgtcgcg tccggtgtga aagtccatcg cttaacggtg gatctgcgcc gggtacgggc 600
gggctggagt gcggtagggg agactggaat tcccggtgta acggtggaat gtgtagatat 660
cgggaagaac accgatggcg aaggcaggtc tctgggccgt cactgacgct gaggagcgaa 720
agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac ggtggacgct 780
ggatgtgggg cacgttccac gtgttccgtg tcggagctaa cgcgttaagc gtcccgcctg 840
gggagtacgg ccgcaaggct aaaactcaaa gaaattgacg ggggcccgca caagcggcgg 900
agcatgcgga ttaattcgat gcaacgcgaa gaaccttacc tgggcttgac atgttcccga 960
cgacgccaga gatggcgttt cccttcgggg cgggttcaca ggtggtgcat ggtcgtcgtc 1020
agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctc gccccgtgtt 1080
gccagcacgt tatggtggga actcacgggg gaccgccggg gttaactcgg aggaaggtgg 1140
ggatgacgtc agatcatcat gccccttacg tccagggctt cacgcatgct acaatggccg 1200
gtacagcggg atgcgacatg gcgacatgga gcggatccct gaaaaccggt ctcagttcgg 1260
atcggagcct gcaacccggc tccgtgaagg cggagtcgct agtaatcgcg gatcagcaac 1320
gccgcggtga atgcgttccc gggccttgta cacaccgccc gtcaagtcat gaaagtgggc 1380
agcacccgaa gccggtggcc taaccccttg tgggatggag ccgtctaagg tgaggctcgt 1440
gattgggact aagtcgtaac aaggtagccg taccggaagg tgcggctg 1488
<210> 79
<211> 1538
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_bifidum
<400> 79
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca agcttgcttg gtggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccatg ctccggaata gctcctggaa acgggtggta atgccggatg 180
ttccacatga tcgcatgtga ttgtgggaaa gattctatcg gcgtgggatg gggtcgcgtc 240
ctatcagctt gttggtgagg taacggctca ccaaggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt gtttgggagc aagccttcgg gtgagtgtac ctttcgaata 480
agcgccggct aactacgtgc cagcagccgc ggtaatacgt agggcgcaag cgttatccgg 540
atttattggg cgtaaagggc tcgtaggcgg ctcgtcgcgt ccggtgtgaa agtccatcgc 600
ttaacggtgg atctgcgccg ggtacgggcg ggctggagtg cggtagggga gactggaatt 660
cccggtgtaa cggtggaatg tgtagatatc gggaagaaca ccgatggcga aggcaggtct 720
ctgggccgtc actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 780
ggtagtccac gccgtaaacg gtggacgctg gatgtggggc acgttccacg tgttccgtgt 840
cggagctaac gcgttaagcg tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag 900
aaattgacgg gggcccgcac aagcggcgga gcatgcggat taattcgatg caacgcgaag 960
aaccttacct gggcttgaca tgttcccgac gacgccagag atggcgtttc ccttcggggc 1020
gggttcacag gtggtgcatg gtcgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctcg ccccgtgttg ccagcacgtt atggtgggaa ctcacggggg 1140
accgccgggg ttaactcgga ggaaggtggg gatgacgtca gatcatcatg ccccttacgt 1200
ccagggcttc acgcatgcta caatggccgg tacagcggga tgcgacatgg cgacatggag 1260
cggatccctg aaaaccggtc tcagttcgga tcggagcctg caacccggct ccgtgaaggc 1320
ggagtcgcta gtaatcgcgg atcagcaacg ccgcggtgaa tgcgttcccg ggccttgtac 1380
acaccgcccg tcaagtcatg aaagtgggca gcacccgaag ccggtggcct aaccccttgt 1440
gggatggagc cgtctaaggt gaggctcgtg attgggacta agtcgtaaca aggtagccgt 1500
accggaaggt gcggctggat cacctccttt ctacggag 1538
<210> 80
<211> 1532
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_bifidum
<400> 80
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca agcttgcttg gtggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccatg ctccggaata gctcctggaa acgggtggta atgccggatg 180
ttccacatga tcgcatgtga ttgtgggaaa gattctatcg gcgtgggatg gggtcgcgtc 240
ctatcagctt gttggtgagg taacggctca ccaaggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt gtttgggagc aagccttcgg gtgagtgtac ctttcgaata 480
agcgccggct aactacgtgc cagcagccgc ggtaatacgt agggcgcaag cgttatccgg 540
atttattggg cgtaaagggc tcgtaggcgg ctcgtcgcgt ccggtgtgaa agtccatcgc 600
ttaacggtgg atctgcgccg ggtacgggcg ggctggagtg cggtagggga gactggaatt 660
cccggtgtaa cggtggaatg tgtagatatc gggaagaaca ccgatggcga aggcaggtct 720
ctgggccgtc actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 780
ggtagtccac gccgtaaacg gtggacgctg gatgtggggc acgttccacg tgttccgtgt 840
cggagctaac gcgttaagcg tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag 900
aaattgacgg gggcccgcac aagcggcgga gcatgcggat taattcgatg caacgcgaag 960
aaccttacct gggcttgaca tgttcccgac gacgtcagag atggcgtttc ccttcggggc 1020
gggttcacag gtggtgcatg gtcgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctcg ccccgtgttg ccagcacgtt atggtgggaa ctcacggggg 1140
accgccgggg ttaactcgga ggaaggtggg gatgacgtca gatcatcatg ccccttacgt 1200
ccagggcttc acgcatgcta caatggccgg tacagcggga tgcgacatgg cgacatggag 1260
cggatccctg aaaaccggtc tcagttcgga tcggagcctg caacccggct ccgtgaaggc 1320
ggagtcgcta gtaatcgcgg atcagcaacg ccgcggtgaa tgcgttcccg ggccttgtac 1380
acaccgcccg tcaagtcatg aaagtgggca gcacccgaag ccggtggcct aaccccttgt 1440
gggatggagc cgtctaaggt gaggctcgtg attgggacta agtcgtaaca aggtagccgt 1500
accggaaggt gcggctggat cacctccttt ct 1532
<210> 81
<211> 1364
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_bifidum
<400> 81
gatccatcgg gctttgcttg gtggtgagag tggcgaacgg gtgagtaatg cgtgaccgac 60
ctgccccatg ctccggaata gctcctggaa acgggtggta atgccggatg ttccacatga 120
tcgcatgtga ttgtgggaaa gattctatcg gcgtgggatg gggtcgcgtc ctatcagctt 180
gttggtgagg taacggctca ccaaggcttc gacgggtagc cggcctgaga gggcgaccgg 240
ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg ggaatattgc 300
acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct tcgggttgta 360
aacctctttt gtttgggagc aagccttcgg gtgagtgtac ctttcgaata agcgccggct 420
aactacgtgc cagcagccgc ggtaatacgt agggcgcaag cgttatccgg atttattggg 480
cgtaaagggc tcgtaggcgg ctcgtcgcgt ccggtgtgaa agtccatcgc ttaacggtgg 540
atctgcgccg ggtacgggcg ggctggagtg cggtagggga gactggaatt cccggtgtaa 600
cggtggaatg tgtagatatc gggaagaaca ccgatggcga aggcaggtct ctgggccgtc 660
actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct ggtagtccac 720
gccgtaaacg gtggacgctg gatgtggggc acgttccacg tgttccgtgt cggagctaac 780
gcgttaagcg tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag aaattgacgg 840
gggcccgcac aagcggcgga gcatgcggat taattcgatg caacgcgaag aaccttacct 900
gggcttgaca tgttcccgac gacgccagag atggcgtttc ccttcggggc gggttcacag 960
gtggtgcatg gtcgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc 1020
gcaaccctcg ccccgtgttg ccagcacgtt atggtgggaa ctcacggggg accgccgggg 1080
ttaactcgga ggaaggtggg gatgacgtca gatcatcatg ccccttacgt ccagggcttc 1140
acgcatgcta caatggccgg tacagcggga tgcgacatgg cgacatggag cggatccctg 1200
aaaaccggtc tcagttcgga tcggagcctg caacccggct ccgtgaaggc ggagtcgcta 1260
gtaatcgcgg atcagcaacg ccgcggtgaa tgcgttcccg ggccttgtac acaccgcccg 1320
tcaagtcatg aaagtgggca gcacccgaag ccggtggcct aacc 1364
<210> 82
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_bifidum
<400> 82
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatcg ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat gctccggaat agctcctgga aacgggtggt aatgccggat 180
gttccacatg atcgcatgtg attgtgggaa agattctatc ggcgtgggat ggggtcgcgt 240
cctatcagct tgttggtgag gtaacggctc accaaggctt cgacgggtag ccggcctgag 300
agggcgaccg gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg 360
gggaatattg cacaatgggc gcaagcctga tgcagcgacg ccgcgtgagg gatggaggcc 420
ttcgggttgt aaacctcttt tgtttgggag caagccttcg ggtgagtgta cctttcgaat 480
aagcgccggc taactacgtg ccagcagccg cggtaatacg tagggcgcaa gcgttatccg 540
gatttattgg gcgtaaaggg ctcgtaggcg gctcgtcgcg tccggtgtga aagtccatcg 600
cttaacggtg gatctgcgcc gggtacgggc gggctggagt gcggtagggg agactggaat 660
tcccggtgta acggtggaat gtgtagatat cgggaagaac accgatggcg aaggcaggtc 720
tctgggccgt cactgacgct gaggagcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac ggtggacgct ggatgtgggg cacgttccac gtgttccgtg 840
tcggagctaa cgcgttaagc gtcccgcctg gggagtacgg ccgcaaggct aaaactcaaa 900
gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa 960
gaaccttacc tgggcttgac atgttcccga cgacgccaga gatggcgttt cccttcgggg 1020
cgggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctc gccccgtgtt gccagcacgt tatggtggga actcacgggg 1140
gaccgccggg gttaactcgg aggaaggtgg ggatgacgtc agatcatcat gccccttacg 1200
tccagggctt cacgcatgct acaatggccg gtacagcggg atgcgacatg gcgacatgga 1260
gcggatccct gaaaaccggt ctcagttcgg atcggagcct gcaacccggc tccgtgaagg 1320
cggagtcgct agtaatcgcg gatcagcaac gccgcggtga atgcgttccc gggccttgta 1380
cacaccgccc gtcaagtcat gaaagtgggc agcacccgaa gccggtggcc taaccccttg 1440
tgggatggag ccgtctaagg tgaggctcgt gattgggact aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga tcacctcctt tct 1533
<210> 83
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_breve
<400> 83
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatcg ggctttgcct ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat gcaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccatcac accgcatggt gtgttgggaa agcctttgcg gcatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt gttagggagc aaggcacttt gtgttgagtg tacctttcga 480
ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc aagcgttatc 540
cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt gaaagtccat 600
cgcttaacgg tggatccgcg ccgggtacgg gcgggcttga gtgcggtagg ggagactgga 660
attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg cgaaggcagg 720
tctctgggcc gttactgacg ctgaggagcg aaagcgtggg gagcgaacag gattagatac 780
cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggcccgttcc acgggttccg 840
tgtcggagct aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca 900
aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg 960
aagaacctta cctgggcttg acatgttccc gacgatccca gagatggggt ttcccttcgg 1020
ggcgggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag 1080
tcccgcaacg agcgcaaccc tcgccccgtg ttgccagcgg attgtgccgg gaactcacgg 1140
gggaccgccg gggttaactc ggaggaaggt ggggatgacg tcagatcatc atgcccctta 1200
cgtccagggc ttcacgcatg ctacaatggc cggtacaacg ggatgcgaca gtgcgagctg 1260
gagcggatcc ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa 1320
ggcggagtcg ctagtaatcg cgaatcagca acgtcgcggt gaatgcgttc ccgggccttg 1380
tacacaccgc ccgtcaagtc atgaaagtgg gcagcacccg aagccggtgg cctaacccct 1440
tgcgggaggg agccgtctaa ggtgaggctc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttct 1535
<210> 84
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_breve
<400> 84
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatcg ggctttgcct ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat gcaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccatcac accgcatggt gtgttgggaa agcctttgcg gcatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt gttagggagc aaggcacttc gtgttgagtg tacctttcga 480
ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc aagcgttatc 540
cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt gaaagtccat 600
cgcttaacgg tggatccgcg ccgggtacgg gcgggcttga gtgcggtagg ggagactgga 660
attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg cgaaggcagg 720
tctctgggcc gttactgacg ctgaggagcg aaagcgtggg gagcgaacag gattagatac 780
cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggcccgttcc acgggttccg 840
tgtcggagct aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca 900
aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg 960
aagaacctta cctgggcttg acatgttccc gacgatccca gagatggggt ttcccttcgg 1020
ggcgggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag 1080
tcccgcaacg agcgcaaccc tcgccccgtg ttgccagcgg attgtgccgg gaactcacgg 1140
gggaccgccg gggttaactc ggaggaaggt ggggatgacg tcagatcatc atgcccctta 1200
cgtccagggc ttcacgcatg ctacaatggc cggtacaacg ggatgcgaca gcgcgagctg 1260
gagcggatcc ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa 1320
ggcggagtcg ctagtaatcg cgaatcagca acgtcgcggt gaatgcgttc ccgggccttg 1380
tacacaccgc ccgtcaagtc atgaaagtgg gcagcacccg aagccggtgg cctaacccct 1440
tgcgggaggg agccgtctaa ggtgaggctc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttct 1535
<210> 85
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_breve
<400> 85
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatcg ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat gcaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccatcac accgcatggt gtgttgggaa agcctttgcg gcatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt gttagggagc aaggcacttt gtgttgagtg tacctttcga 480
ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc aagcgttatc 540
cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt gaaagtccat 600
cgcttaacgg tggatccgcg ccgggtacgg gcgggcttga gtgcggtagg ggagactgga 660
attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg cgaaggcagg 720
tctctgggcc gttactgacg ctgaggagcg aaagcgtggg gagcgaacag gattagatac 780
cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggcccgttcc acgggttccg 840
tgtcggagct aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca 900
aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg 960
aagaacctta cctgggcttg acatgttccc gacgatccca gagatggggt ttcccttcgg 1020
ggcgggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag 1080
tcccgcaacg agcgcaaccc tcgccccgtg ttgccagcgg attgtgccgg gaactcacgg 1140
gggaccgccg gggttaactc ggaggaaggt ggggatgacg tcagatcatc atgcccctta 1200
cgtccagggc ttcacgcatg ctacaatggc cggtacaacg ggatgcgaca gtgcgagctg 1260
gagcggatcc ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa 1320
ggcggagtcg ctagtaatcg cgaatcagca acgtcgcggt gaatgcgttc ccgggccttg 1380
tacacaccgc ccgtcaagtc atgaaagtgg gcagcacccg aagccggtgg cctaacccct 1440
tgcgggaggg agccgtctaa ggtgaggctc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttct 1535
<210> 86
<211> 1406
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_breve
<400> 86
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gggatccatc gggctttgcc 60
tggtggtgag agtggcgaac gggtgagtaa tgcgtgaccg acctgcccca tgcaccggaa 120
tagctcctgg aaacgggtgg taatgccgga tgctccatca caccgcatgg tgtgttggga 180
aagcctttgc ggcatgggat ggggtcgcgt cctatcagct tgatggcggg gtaacggccc 240
accatggctt cgacgggtag ccggcctgag agggcgaccg gccacattgg gactgagata 300
cggcccagac tcctacggga ggcagcagtg gggaatattg cacaatgggc gcaagcctga 360
tgcagcgacg ccgcgtgagg gatggaggcc ttcgggttgt aaacctcttt tgttagggag 420
caaggcactt tgtgttgagt gtacctttcg aataagcacc ggctaactac gtgccagcag 480
ccgcggtaat acgtagggtg caagcgttat ccggaattat tgggcgtaaa gggctcgtag 540
gcggttcgtc gcgtccggtg tgaaagtcca tcgcttaacg gtggatccgc gccgggtacg 600
ggcgggcttg agtgcggtag gggagactgg aattcccggt gtaacggtgg aatgtgtaga 660
tatcgggaag aacaccaatg gcgaaggcag gtctctgggc cgttactgac gctgaggagc 720
gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta aacggtggat 780
gctggatgtg gggcccgttc cacgggttcc gtgtcggagc taacgcgtta agcatcccgc 840
ctggggagta cggccgcaag gctaaaactc aaagaaattg acgggggccc gcacaagcgg 900
cggagcatgc ggattaattc gatgcaacgc gaagaacctt acctgggctt gacatgttcc 960
cgacgatccc agagatgggg tttcccttcg gggcgggttc acaggtggtg catggtcgtc 1020
gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac gagcgcaacc ctcgccccgt 1080
gttgccagcg gattgtgccg ggaactcacg ggggaccgcc ggggttaact cggaggaagg 1140
tggggatgac gtcagatcat catgcccctt acgtccaggg cttcacgcat gctacaatgg 1200
ccggtacaac gggatgcgac agtgcgagct ggagcggatc cctgaaaacc ggtctcagtt 1260
cggatcgcag tctgcaactc gactgcgtga aggcggagtc gctagtaatc gcgaatcagc 1320
aacgtcgcgg tgaatgcgtt cccgggcctt gtacacaccg cccgtcaagt catgaaagtg 1380
ggcagcaccc gaagccggtg gcctaa 1406
<210> 87
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_breve
<400> 87
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatcg ggctttgcct ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat gcaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccatcac accgcatggt gtgttgggaa agcctttgcg gcatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt gttagggagc aaggcacttt gtgttgagtg tacctttcga 480
ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc aagcgttatc 540
cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt gaaagtccat 600
cgcttaacgg tggatccgcg ccgggtacgg gcgggcttga gtgcggtagg ggagactgga 660
attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg cgaaggcagg 720
tctctgggcc gttactgacg ctgaggagcg aaagcgtggg gagcgaacag gattagatac 780
cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggcccgttcc acgggttccg 840
tgtcggagct aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca 900
aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg 960
aagaacctta cctgggcttg acatgttccc gacgatccca gagatggggt ttcccttcgg 1020
ggcgggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag 1080
tcccgcaacg agcgcaaccc tcgccccgtg ttgccagcgg attatgccgg gaactcacgg 1140
gggaccgccg gggttaactc ggaggaaggt ggggatgacg tcagatcatc atgcccctta 1200
cgtccagggc ttcacgcatg ctacaatggc cggtacaacg ggatgcgaca gcgcgagctg 1260
gagcggatcc ctgaaaaccg gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa 1320
ggcggagtcg ctagtaatcg cgaatcagca acgtcgcggt gaatgcgttc ccgggccttg 1380
tacacaccgc ccgtcaagtc atgaaagtgg gcagcacccg aagccggtgg cctaacccct 1440
tgcgggaggg agccgtctaa ggtgaggctc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttct 1535
<210> 88
<211> 1532
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_catenulatum
<400> 88
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccaggc agcttgctgc ctggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ctccgactcc tcgcatgggg tgtcgggaaa gatttcatcg gtatgggatg gggtcgcgtc 240
ctatcaggta gtcggcgggg taacggccca ccgagcctac gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgcggg atgacggcct 420
tcgggttgta aaccgctttt gatcgggagc aagccttcgg gtgagtgtac ctttcgaata 480
agcaccggct aactacgtgc cagcagccgc ggtaatacgt agggtgcaag cgttatccgg 540
aattattggg cgtaaagggc tcgtaggcgg ttcgtcgcgt ccggtgtgaa agtccatcgc 600
ttaacggtgg atctgcgccg ggtacgggcg ggctggagtg cggtagggga gactggaatt 660
cccggtgtaa cggtggaatg tgtagatatc gggaagaaca ccaatggcga aggcaggtct 720
ctgggccgtt actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 780
ggtagtccac gccgtaaacg gtggatgctg gatgtggggc ccgttccacg ggttccgtgt 840
cggagctaac gcgttaagca tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag 900
aaattgacgg gggcccgcac aagcggcgga gcatgcggat taattcgatg caacgcgaag 960
aaccttacct gggcttgaca tgttcccgac agccgtagag atacggtctc ccttcggggc 1020
gggttcacag gtggtgcatg gtcgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctcg ccctgtgttg ccagcacgtc atggtgggaa ctcacggggg 1140
accgccgggg tcaactcgga ggaaggtggg gatgacgtca gatcatcatg ccccttacgt 1200
ccagggcttc acgcatgcta caatggccgg tacaacggga tgcgacatgg cgacatggag 1260
cggatccctg aaaaccggtc tcagttcgga ttggagtctg caacccgact ccatgaaggc 1320
ggagtcgcta gtaatcgcgg atcagcaacg ccgcggtgaa tgcgttcccg ggccttgtac 1380
acaccgcccg tcaagtcatg aaagtgggta gcacccgaag ccggtggcct aaccccttgt 1440
gggatggagc cgtctaaggt gagactcgtg attgggacta agtcgtaaca aggtagccgt 1500
accggaaggt gcggctggat cacctccttt ct 1532
<210> 89
<211> 1480
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_catenulatum
<400> 89
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gggatccagg cagcttgctg 60
cctggtgaga gtggcgaacg ggtgagtaat gcgtgaccga cctgccccat acaccggaat 120
agctcctgga aacgggtggt aatgccggat gctccgactc ctcgcatggg gtgtcgggaa 180
agatttcatc ggtatgggat ggggtcgcgt cctatcaggt agtcggcggg gtaacggccc 240
accgagccta cgacgggtag ccggcctgag agggcgaccg gccacattgg gactgagata 300
cggcccagac tcctacggga ggcagcagtg gggaatattg cacaatgggc gcaagcctga 360
tgcagcgacg ccgcgtgcgg gatgacggcc ttcgggttgt aaaccgcttt tgatcgggag 420
caagccttcg ggtgagtgta cctttcgaat aagcaccggc taactacgtg ccagcagccg 480
cggtaatacg tagggtgcaa gcgttatccg gaattattgg gcgtaaaggg ctcgtaggcg 540
gttcgtcgcg tccggtgtga aagtccatcg cttaacggtg gatctgcgcc ggctacgggc 600
gggctggagt gcggtagggg agactggaat tcccggtgta acggtggaat gtgtagatat 660
cgggaagaac accaatggcg aaggcaggtc tctgggccgt tactgacgct gaggagcgaa 720
agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac ggtggatgct 780
ggatgtgggg cccgttccac gggttccgtg tcggagctaa cgcgttaagc atcccgcctg 840
gggagtacgg ccgcaaggct aaaactcaaa gaaattgacg ggggcccgca caagcggcgg 900
agcatgcgga ttaattcgat gcaacgcgaa gaaccttacc tgggcttgac atgttcccga 960
cagccgtaga gatacggtct cccttcgggg cgggttcaca ggtggtgcat ggtcgtcgtc 1020
agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctc gccctgtgtt 1080
gccagcacgt catggtggga actcacgggg gaccgccggg gtcaactcgg aggaaggtgg 1140
ggatgacgtc agatcatcat gccccttacg tccagggctt cacgcatgct acaatggccg 1200
gtacaacggg atgcgacatg gcgacatgga gcggatccct gaaaaccggt ctcagttcgg 1260
attggagtct gcaacccgac tccatgaagg cggagtcgct agtaatcgcg gatcagcaac 1320
gccgcggtga atgcgttccc gggccttgta cacaccgccc gtcaagtcat gaaagtgggt 1380
agcacccgaa gccggtggcc taaccccttg tgggatggag ccgtctaagg tgagactcgt 1440
gattgggact aagtcgtaac aaggcagccg taccggaagg 1480
<210> 90
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_dentium
<400> 90
ttttcgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatcccggg ggttcgcctc cgggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ctccggttgg atgcatgtcc ttccgggaaa ggttccatcg gtatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgcggg atggaggcct 420
tcgggttgta aaccgctttt gatcgggagc aagcccttcg gggtgagtgt acccttcgaa 480
taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgca agcgttatcc 540
ggaattattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg aaagcccatc 600
gcttaacggt gggtctgcgc cgggtacggg cgggctggag tgcggtaggg gagactggaa 660
ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc gaaggcaggt 720
ctctgggccg tcactgacgc tgaggagcga aagcgtgggg agcgaacagg attagatacc 780
ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gcccgttcca cgggttccgt 840
gtcggagcta acgcgttaag catcccgcct ggggagtacg gccgcaaggc taaaactcaa 900
agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga tgcaacgcga 960
agaaccttac ctgggcttga catgttcccg acggccgtag agatacggcc tcccttcggg 1020
gcgggttcac aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct cgccctgtgt tgccagcacg tcatggtggg aactcacggg 1140
ggaccgccgg ggtcaactcg gaggaaggtg gggatgacgt cagatcatca tgccccttac 1200
gtccagggct tcacgcatgc tacaatggcc ggtacagcgg gatgcgacat ggcgacatgg 1260
agcggatccc tgaaaaccgg tctcagttcg gattggagtc tgcaacccga ctccatgaag 1320
gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc cgggccttgt 1380
acacaccgcc cgtcaagtca tgaaagtggg cagcacccga agccggtggc ctaacccttc 1440
tgtgggatgg agccgtctaa ggtgaggctc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttct 1535
<210> 91
<211> 1539
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_dentium
<400> 91
ttttcgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatcccggg ggttcgcctc cgggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ctccggttgg atgcatgtcc ttccgggaaa ggttccatcg gtatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgcggg atggaggcct 420
tcgggttgta aaccgctttt gatcgggagc aagcccttcg gggtgagtgt acccttcgaa 480
taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgca agcgttatcc 540
ggaattattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg aaagcccatc 600
gcttaacggt gggtctgcgc cgggtacggg cgggctggag tgcggtaggg gagactggaa 660
ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc gaaggcaggt 720
ctctgggccg tcactgacgc tgaggagcga aagcgtgggg agcgaacagg attagatacc 780
ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gcccgttcca cgggttccgt 840
gtcggagcta acgcgttaag catcccgcct ggggagtacg gccgcaaggc taaaactcaa 900
agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga tgcaacgcga 960
agaaccttac ctgggcttga catgttcccg acggccgtag agatacggcc tcccttcggg 1020
gcgggttcac aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct cgccctgtgt tgccagcacg tcatggtggg aactcacggg 1140
ggaccgccgg ggtcaactcg gaggaaggtg gggatgacgt cagatcatca tgccccttac 1200
gtccagggct tcacgcatgc tacaatggcc ggtacagcgg gatgcgacat ggcgacatgg 1260
agcggatccc tgaaaaccgg tctcagttcg gattggagtc tgcaacccga ctccatgaag 1320
gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc cgggccttgt 1380
acacaccgcc cgtcaagtca tgaaagtggg cagcacccga agccggtggc ctaacccttc 1440
tgtgggatgg agccgtctaa ggtgaggctc gtgattggga ctaagtcgta acaaggtagc 1500
cgtaccggaa ggtgcggctg gatcacctcc tttctacgg 1539
<210> 92
<211> 1534
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_dentium
<400> 92
tttttatgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatcccggg ggttcgctcc cgggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ctccggttgg atgcatgtcc ttccgggaaa gattccatcg gtatgggatg gggtcgcgtc 240
ctatcagctt gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgcggg atggaggcct 420
tcgggttgta aaccgctttt gatcgggagc aagcccttcg gggtgagtgt acctttcgaa 480
taagcaccgg ctaactacgt gccagcagcc gcggtaatac gtagggtgca agcgttatcc 540
ggaattattg ggcgtaaagg gctcgtaggc ggttcgtcgc gtccggtgtg aaagcccatc 600
gcttaacggt gggtctgcgc cgggtacggg cgggctggag tgcggtaggg gagactggaa 660
ttcccggtgt aacggtggaa tgtgtagata tcgggaagaa caccaatggc gaaggcaggt 720
ctctgggccg tcactgacgc tgaggagcga aagcgtgggg agcgaacagg attagatacc 780
ctggtagtcc acgccgtaaa cggtggatgc tggatgtggg gcccgttcca cgggttccgt 840
gtcggagcta acgcgttaag catcccgcct ggggagtacg gccgcaaggc taaaactcaa 900
agaaattgac gggggcccgc acaagcggcg gagcatgcgg attaattcga tgcaacgcga 960
agaaccttac ctgggcttga catgttcccg acagccgtag agatatggcc tcccttcggg 1020
gcgggttcac aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct cgccctgtgt tgccagcacg tcatggtggg aactcacggg 1140
ggaccgccgg ggtcaactcg gaggaaggtg gggatgacgt cagatcatca tgccccttac 1200
gtccagggct tcacgcatgc tacaatggcc ggtacagcgg gatgcgacat ggcgacatgg 1260
agcggatccc tgaaaaccgg tctcagttcg gattggagtc tgcaacccga ctccatgaag 1320
gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc cgggccttgt 1380
acacaccgcc cgtcaagtca tgaaagtggg cagcacccga agccggtggc ctaacccctt 1440
gcgggatgga gccgtctaag gtgaggctcg tgattgggac taagtcgtaa caaggtagcc 1500
gtaccggaag gtgcggctgg atcacctcct ttct 1534
<210> 93
<211> 1477
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_dentium
<220>
<221> misc_feature
<222> (94)..(94)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (136)..(136)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (176)..(176)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (206)..(206)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (231)..(232)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (236)..(236)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (255)..(255)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (259)..(259)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (267)..(268)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (286)..(287)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (334)..(335)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (387)..(387)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (400)..(403)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (409)..(409)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (436)..(436)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (510)..(510)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (529)..(529)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (570)..(572)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (579)..(580)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (612)..(613)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (715)..(715)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (728)..(728)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (730)..(731)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (821)..(821)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (829)..(829)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (863)..(863)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (911)..(912)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (915)..(915)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (927)..(927)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (949)..(950)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (974)..(974)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (986)..(986)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1006)..(1008)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1022)..(1022)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1033)..(1033)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1277)..(1277)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1356)..(1356)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1368)..(1368)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1372)..(1372)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1386)..(1386)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1394)..(1394)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1407)..(1407)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1434)..(1434)
<223> n is a, c, g, or t
<400> 93
tttcgtggag ggttcgattc tggctcagga tgaacgctgg cggcgtgctt aacacatgca 60
agtcgaacgg gatcccgggg gttcgcctcc gggngagagt ggcgaacggg tgagtaatgc 120
gtgaccgacc tgcccnatac accggaatag ctcctggaaa cgggtggtaa tgccgnatgc 180
tccggttgga tgcatgtcct tccggnaaag gttccatcgg tatgggatgg nntcgngtcc 240
tatcagcttg atggngggnt aacggcnnac catggcttcg acgggnngcc ggcctgagag 300
ggcgaccggc cacattggga ctgagatacg gccnngactc ctacgggagg cagcagtggg 360
gaatattgca caatgggcgc aagcctnatg cagcgacgcn nnntgcggna tggaggcctt 420
cgggttgtaa accgcntttg atcgggagca agcccttcgg ggtgagtgta cccttcgaat 480
aagcaccggc taactacgtg ccagcagccn cggtaatacg tagggtgcna gcgttatccg 540
gaattattgg gcgtaaaggg ctcgtaggcn nntcgtcgnn tccggtgtga aagcccatcg 600
cttaacggtg gnnctgcgcc gggtacgggc gggctggagt gcggtagggg agactggaat 660
tcccggtgta acggtggaat gtgtagatat cgggaagaac accaatggcg aaggnaggtc 720
tctgggcngn nactgacgct gaggagcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg ngttccacng gttccgtgtc 840
ggagctaacg cgttaagcat ccngcctggg gagtacggcc gcaaggctaa aactcaaaga 900
aattgacggg nnccngcaca agcggcngag catgcggatt aattcgatnn aacgcgaaga 960
accttacctg ggcntgacat gttccngacg gccgtagaga tacggnnncc ttcgggacgg 1020
gntcacaggt ggngcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aaccctcgcc ctgtgttgcc agcacgtcac ggtgggaact cacgggggac 1140
cgccggggtc aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc 1200
agggcttcac gcatgctaca atggccggta cagcgggatg cgacatggcg acatggagcg 1260
gatccctgaa aaccggnctc agttcggatt ggagtctgca acccgactcc atgaaggcgg 1320
agtcgctagt aatcgcggat cagcaacgcc gcggtnaatg cgttcccngg cnttgtacac 1380
accgcncgtc aagncatgaa agtgggnagc acccgaagcc ggtggcctaa cccntctgtg 1440
ggatggagcc gtctaaggtg aggctcgtga ttgggac 1477
<210> 94
<211> 1551
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_gallicum
<400> 94
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccggcc gagcttgtct tggctggtga gagtggcgaa cgggtgagta 120
atgcgtgacc aacctgcctt gtgcaccgga atagctcctg gaaacgggtg gtaataccgg 180
atgttccgct ccatcgcatg gtggtgtggg aaatgctttt gcggcatggg atggggtcgc 240
gtcctatcag cttgttggcg gggtgacggc ccaccaaggc tttgacgggt agccggcctg 300
agagggtgac cggccacatt gggactgaga tacggcccag actcctacgg gaggcagcag 360
tggggaatat tgcacaatgg gcgcaagcct gatgcagcga cgccgcgtgc gggatggagg 420
ccttcgggtt gtaaaccgct tttgattgtc agcaaggcgt cctttcgggg atgttgagtg 480
tagctttcga ataagcaccg gctaactacg tgccagcagc cgcggtaata cgtagggtgc 540
aagcgttatc cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg cgtccggtgt 600
gaaagtccat cgcttaacgg tggatctgcg ccgggtacgg gcgggctgga gtgcggtagg 660
ggagactgga attcccggtg taacggtgga atgtgtagat atcgggaaga acaccaatgg 720
cgaaggcagg tctctgggcc gttactgacg ctgaggagcg aaagcgtggg gagcgaacag 780
gattagatac cctggtagtc cacgccgtaa acggtggatg ctggatgtgg ggcccttttt 840
ccgggtcctg tgtcggagct aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg 900
ctaaaactca aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg 960
atgcaacgcg aagaacctta cctgggcttg acatgttccg gatcgcccca gagatggggt 1020
ttcccttcgg ggccggttca caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg 1080
ttgggttaag tcccgcaacg agcgcaaccc tcgccgcgtg ttgccagcgg gtcatgccgg 1140
gaactcacgt gggaccgccg gggtcaactc ggaggaaggt ggggatgacg tcagatcatc 1200
atgcccctta cgtccagggc ttcacgcatg ctacaatggc cggtacaacg ggatgcgaca 1260
ccgtgaggtg gggcggatcc ctgaaaaccg gtctcagttc ggatcgcagt ctgcaacccg 1320
actgcgtgaa ggcggagtcg ctagtaatcg cagatcagca acgctgcggt gaatgcgttc 1380
ccgggccttg tacacaccgc ccgtcaagtc atgaaagtgg gtagcacccg aagccggtgg 1440
cccgaccgcc ttgtgtgggg ggagccgtct aaggtgagac tcgtgattgg gactaagtcg 1500
taacaaggta gccgtaccgg aaggtgcggc tggatcacct cctttctacg g 1551
<210> 95
<211> 1400
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_infantis
<400> 95
gattctggct caggatgaac gctggcggcg tgcttaacac atgcaagtcg aacgggatcc 60
atcaggcttt gcttggtggt gagagtggcg aacgggtgag taatgcgtga ccgacctgcc 120
ccatacaccg gaatagctcc tggaaacggg tggtaatgcc ggatgctcca gttgatcgca 180
tggtcttctg ggaaagcttt cgcggtatgg gatggggtcg cgtcctatca gcttgacggc 240
ggggtaacgg cccaccgtgg cttcgacggg tagccggcct gagagggcga ccggccacat 300
tgggactgag atacggccca gactcctacg ggaggcagca gtggggaata ttgcacaatg 360
ggcgcaagcc tgatgcagcg acgccgcgtg agggatggag gccttcgggt tgtaaacctc 420
ttttatcggg gagcaagcga gagtgagttt acccgttgaa taagcaccgg ctaactacgt 480
gccagcagcc gcggtaatac gtagggtgca agcgttatcc ggaattattg ggcgtaaagg 540
gctcgtaggc ggttcgtcgc gtccggtgtg aaagtccatc gcttaacggt ggatccgcgc 600
cgggtacggg cgggcttgag tgcggtaggg gagactggaa ttcccggtgt aacggtggaa 660
tgtgtagata tcgggaagaa caccaatggc gaaggcaggt ctctgggccg ttactgacgc 720
tgaggagcga aagccgtggg gagcgaacag gattagatac cctggtagtc cacgccgtaa 780
acggtggatg ctggatgtgg ggcccgttcc acgggttccg tgtcggagct aacgcgttaa 840
gcatcccgcc tggggagtac ggccgcaagc taaaaactca aagaaattga cgggggcccg 900
cacaagcggc ggagcatgcg gattaattcg atcgaacgcg aagaacctta cctgggcttg 960
acatgttccc gacggtcgta gagatacggc ttcccttcgg ggcgggttca caggtggtgc 1020
atggtcgtcg tcacgtcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc 1080
tcgccccgtg ttgccagcgg attatgccgg gaactcacgg gggaccgccg gggttaactc 1140
ggaggaaggt ggggatgacg tcagatcatc atgcccctta cgtccagggc ttcacgcatg 1200
ctacaatggc cggtacaacg ggatgcgacg cggcgacgcg gagcggatcc ctgaaaaccg 1260
gtctcagttc ggatcgcagt ctgcaactcg actgcgtgaa ggcggagtcg ctagtaatcg 1320
cgaatcagca acgtcgcggt gaatgcgttc ccgggccttg tacacaccgc ccgtcaagtc 1380
atgaaagtgg gtagcacccg 1400
<210> 96
<211> 1515
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_kashiwanohense
<400> 96
agggttcgat tctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gggatcccag gagcttgctc ctgggtgtta gtggcgaacg ggtgagtaat gcgtgaccga 120
cctgccccat gcaccggaat agctcctgga aacgggtggt aatgccggat gctccatcac 180
actgcatggt gtgttgggaa agcctttgcg gcatgggatg gggtcgcgtc ctatcagctt 240
gatggcgggg taacggccca ccatggcttc gacgggtagc cggcctgaga gggcgaccgg 300
ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg ggaatattgc 360
acaatgggcg caagcctgat gcagcgacgc cgcgtgcggg atgacggcct tcgggttgta 420
aaccgctttt gatcgggagc aagccttcgg gtgagtgtac ctttcgaata agcaccggct 480
aactacgtgc cagcagccgc ggtaatacgt agggtgcaag cgttatccgg aattattggg 540
cgtaaagggc tcgtaggcgg ttcgtcgcgt ccggtgtgaa agtccatcgc ttaacggtgg 600
atctgcgccg ggtacgggcg ggctggagtg cggtagggga gactggaatt cccggtgtaa 660
cggtggaatg tgtagatatc gggaagaaca ccaatggcga aggcaggtct ctgggccgtt 720
actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct ggtagtccac 780
gccgtaaacg gtggatgctg gatgtggggc ccgttccacg ggttccgtgt cggagctaac 840
gcgttaagca tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag aaattgacgg 900
gggcccgcac aagcggcgga gcatgcggat taattcgatg caacgcgaag aaccttacct 960
gggcttgaca tgttcccgac cgttccagag atggggcttc ccttcggggc gggttcacag 1020
gtggtgcatg gtcgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc 1080
gcaaccctcg ccctgtgttg ccagcacgtc atggtgggaa ctcacggggg accgccgggg 1140
tcaactcgga ggaaggtggg gatgacgtca gatcatcatg ccccttacgt ccagggcttc 1200
acgcatgcta caatggccgg tacaacggga tgcgacacgg cgacgtggag cggatccctg 1260
aaaaccggtc tcagttcgga ttggagtctg caacccgact ccatgaaggc ggagtcgcta 1320
gtaatcgcgg atcagcaacg ccgcggtgaa tgcgttcccg ggccttgtac acaccgcccg 1380
tcaagtcatg aaagtgggta gcacccgaag ccggtggcct aacccttcgt gggatggagc 1440
cgtctaaggt gagactcgtg attgggacta agtcgtaaca aggtaaccgt accggaaggt 1500
gcggctggat cacct 1515
<210> 97
<211> 1348
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 97
gtggcgaacg ggtgagtaat gcgtgaccga cctgccccat acaccggaat agctcctgga 60
aacgggtggt aatgccggat gctccagttg atcgcatggt cttctgggaa agctttcgcg 120
gtatgggatg gggtcgcgtc ctatcagctt gacggcgggg tcaacggctc caccgtggct 180
tcsacgggta gccsgaccat gagagggcga ccgsccacat tgggactgar atacggccca 240
gactcctacg ggaggcagca gtggggaata ttgcacaatg ggcgcaagcc tgatgcarcg 300
acsccgcgtg agggatggag gccttcsggt tgtaaacctc ttttatcggg gagcaagcga 360
gagtgagttt acccgttgaa taagcaccgs ctaactacgt gccagcagcc gcggtaatac 420
gtagggtgca agcgttatcc ggaattattg ggcgtaaagg gctcgtaggc ggttcgtcgc 480
gtccggtgtg aaagtccatc gcttaacggt ggatccgcgc cgggtacrgg cgggctttga 540
gtgcggtagg ggagactgga attyccsgtg taacggtgga atgtgtagat atcgggaaga 600
acaccaatgg gcgaaggcag gtctctgggc cgttactgac gctgaggagc gaaagcgtgg 660
ggagcgaaca ggattagata ccctggtagt ccacgccgta aacgggtgga tgctggatgt 720
ggggcccgtt wcacgggtty ccgtgtcgga gctaacgcgt taagcatccc gcctggggag 780
tacggccgca aggctaaaac tcaaagaaat tgacgggggc ccgcacaagc ggcggagcat 840
gcggattaat tcgatgcaac gcgaagaacc ttacctgggc ttgacatgtt cccgacggtc 900
gtagagatac ggcttccctt cggggcgggt tcacaggtgg tgcatggtcg tcgtcagctc 960
gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa ccctcgcccc gtgttgccag 1020
cggattatgc cgggaactca cgggggaccg ccggggttaa ctcggaggaa ggtggggatg 1080
acgtcagatc atcatgcccc ttacgtccag ggcttcacgc atgctacaat ggccggtaca 1140
acgggatgcg acgcggtgac gcggagcgga tccctgaaaa ccggtctcag ttcggatcgc 1200
agtctgcaac tcgactgcgt gaaggcggag tcgctagtaa tcgcgaatca gcaacgtcgc 1260
ggtgaatgcg ttcccgggcc ttgtacacac cgcccgtcaa gtcatgaaag tgggcagcac 1320
ccgaagccgg tggcctaacc ccttgtgg 1348
<210> 98
<211> 1331
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 98
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gagtggcgaa cgggtgagta 60
atgcgtgacc gacctgcccc atacaccgga atagctcctg gaaacgggtg gtaatgccgg 120
atgctgaaag gcggtatggg atggggtcgc gtcctatcag cttgacggcg gggtaacggc 180
ccaccgtggc ttcgacgggt agccggcctg agagggcgac cggccacatt gggactgaga 240
tacggcccag actcctacgg gaggcagcag tggggaatat tgcacaatgg gcgcaagcct 300
gatgcagcga cgccgcgtga gggatggagg ccttcgggtt gtaaacctct tttatcgggg 360
agcatgagtt tacccgttga ataagcaccg gctaactacg tgccagcagc cgcggtaata 420
cgtagggtgc aagcgttatc cggaattatt gggcgtaaag ggctcgtagg cggttcgtcg 480
cgtccggtgt gaaagtccat cgcttaacgg tggatccgcg ccgggtacgg gcgggcttga 540
gtgcggtagg ggagactgga attcccggtg taacggtgga atgtgtagat atcgggaaga 600
acaccaatgg cgaaggcagg tctctgggcc gactgacgct gaggagcgaa agcgtgggga 660
gcgaacagga ttagataccc tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg 720
cgttccgtgt cggagctaac gcgttaagca tcccgcctgg ggagtacggc cgcaaggcta 780
aaactcaaag aaattgacgg gggcccgcac aagcggcgga gcatgcggat taattcgatg 840
caacgcgaag aaccttacct gggcttgaca tgcacaggtg gtgcatggtc gtcgtcagct 900
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca accctcgccc cgtgttgcca 960
gcggccggga actcacgggg gaccgccggg gttaactcgg aggaaggtgg ggatgacgtc 1020
agatcatcat gccccttacg tccagggctt cacgcatgct acaatggccg gcaacgggat 1080
gcgacgcggc gacgcggagc ggatccctgc cggtctcagt tcggacgcag tctgcaactc 1140
gactgcggaa ggcggagtcg ctagtaatcg cgaatcagca acgtcgcggt gaatgcgttc 1200
ccgggccttg tacacaccgc ccgtcaagtc atgaaagtgg gcagcacccg aagccggtgc 1260
ctatggagcc gtctaaggtg aggctcgtga ttgggactaa gtcgtaacaa ggtagccgta 1320
ccggaaggtg c 1331
<210> 99
<211> 1228
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 99
cgaacgagtg gcgaacgggt gagtaatgcg tgaccgacct gccccataca ccggaatagc 60
tcctggaaac gggtggtaat gccggatgct gaaaggcggt atgggatggg gtcgcgtcct 120
atcagcttga cggcggggta acggcccacc gtggcttcga cgggtagccg gcctgagagg 180
gcgaccggcc acattgggac tgagatacgg cccagactcc tacgggaggc agcagtgggg 240
aatattgcac aatgggcgca agcctgatgc agcgacgccg cgtgagggat ggaggccttc 300
gggttgtaaa cctcttttat cggggagcat gagtttaccc gttgaataag caccggctaa 360
ctacgtgcca gcagccgcgg taatacgtag ggtgcaagcg ttatccggaa ttattgggcg 420
taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgctt aacggtggat 480
ccgcgccggg tacgggcggg cttgagtgcg gtaggggaga ctggaattcc cggtgtaacg 540
gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct gggccgactg 600
acgctgagga gcgaaagcgt ggggagcgaa caggattaga taccctggta gtccacgccg 660
taaacggtgg atgctggatg tggggcgttc cgtgtcggag ctaacgcgtt aagcatcccg 720
cctggggagt acggccgcaa ggctaaaact caaagaaatt gacgggggcc cgcacaagcg 780
gcggagcatg cggattaatt cgatgcaacg cgaagaacct tacctgggct tgacatgcac 840
aggtggtgca tggtcgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga 900
gcgcaaccct cgccccgtgt tgccagcggc cgggaactca cgggggaccg ccggggttaa 960
ctcggaggaa ggtggggatg acgtcagatc atcatgcccc ttacgtccag ggcttcacgc 1020
atgctacaat ggccggcaac gggatgcgac gcggcgacgc ggagcggatc cctgccggtc 1080
tcagttcgga cgcagtctgc aactcgactg cggaaggcgg agtcgctagt aatcgcgaat 1140
cagcaacgtc gcggtgaatg cgttcccggg ccttgtacac accgcccgtc aagtcatgaa 1200
agtgggcagc acccgaagcc ggtgccta 1228
<210> 100
<211> 1526
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 100
tgtggagggt tcgattctgg ctcaggatga acgctggcgg cgtgcttaac acatgcaagt 60
cgaacgggat ccatcaggct ttgcttggtg gtgagagtgg cgaacgggtg agtaatgcgt 120
gaccgacctg ccccatacac cggaatagct cctggaaacg ggtggtaatg ccggatgctc 180
cagttgatcg catggtcttc tgggaaagct ttcgcggtat gggatggggt cgcgtcctat 240
cagcttgacg gcggggtaac ggcccaccgt ggcttcgacg ggtagccggc ctgagagggc 300
gaccggccac attgggactg agatacggcc cagactccta cgggaggcag cagtggggaa 360
tattgcacaa tgggcgcaag cctgatgcag cgacgccgcg tgagggatgg aggccttcgg 420
gttgtaaacc tcttttatcg gggagcaagc gagagtgagt ttacccgttg aataagcacc 480
ggctaactac gtgccagcag ccgcggtaat acgtagggtg caagcgttat ccggaattat 540
tgggcgtaaa gggctcgtag gcggttcgtc gcgtccggtg tgaaagtcca tcgcttaacg 600
gtggatccgc gccgggtacg ggcgggcttg agtgcggtag gggagactgg aattcccggt 660
gtaacggtgg aatgtgtaga tatcgggaag aacaccaatg gcgaaggcag gtctctgggc 720
cgttactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt 780
ccacgccgta aacggtggat gctggatgtg gggcccgttc cacgggttcc gtgtcggagc 840
taacgcgtta agcatcccgc ctggggagta cggccgcaag gctaaaactc aaagaaattg 900
acgggggccc gcacaagcgg cggagcatgc ggattaattc gatgcaacgc gaagaacctt 960
acctgggctt gacatgttcc cgacggtcgt agagatgcgg cttcccttcg gggcgggttc 1020
acaggtggtg catggtcgtc gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac 1080
gagcgcaacc ctcgccccgt gttgccagcg gattatgccg ggaactcacg ggggaccgcc 1140
ggggttaact cggaggaagg tggggatgac gtcagatcat catgcccctt acgtccaggg 1200
cttcacgcat gctacaatgg ccggtacaac gggatgcgac gcggcgacgc ggagcggatc 1260
cctgaaaacc ggtctcagtt cggatcgcag tctgcaactc gactgcgtga aggcggagtc 1320
gctagtaatc gcgaatcagc aacgtcgcgg tgaatgcgtt cccgggcctt gtacacaccg 1380
cccgtcaagt catgaaagtg ggcagcaccc gaagccggtg gcctaacccc ttgtgggatg 1440
gagccgtcta aggtgaggct cgtgattggg actaagtcgt aacaaggtag ccgtaccgga 1500
aggtgcggct ggatcacctc ctttct 1526
<210> 101
<211> 1242
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 101
atgggattgg gtttcctttc tatcagatga cgggggggta acccccccac ggttgcttcg 60
gggggtagcc ggcgtgagag ggccgaccgc ctcattgtga gtgagatacg gccctgattc 120
gtacgggagc cagcagtagt gattatcgca caatgcaagc aagcctgatg cagggacgcc 180
gcgtgaggaa tggaggcctt cggtttgtaa acctcgttta tgggggagca agcgagagtg 240
agtttacccg ttgaataagc accggctaac tacgtgccag cagccgcggt aatacgtagg 300
gtgcaagcgt tatccggaat tattgggcgt aaagggctcg taggcggttc gtcgcgtccg 360
gtgtgaaagt ccatcgctta acggtggatc cgcgccgggt acgggcgggc ttgagtgcgg 420
taggggagac tggaattccc ggtgtaacgg tggaatgtgt agatatcggg aagaacacca 480
atggcgaagg caggtctctg ggccgtcact gacgctgagg agcgaaagcg tggggagcga 540
acaggattag ataccctggt agtccacgcc gtaaacggtg gatgctggat gtggggcccg 600
ttccacgggt tccgtgtcgt agcctaacgc gttaagcatc ctgcctgggg agtacggccg 660
caaggctaat actcaaagaa atagatgggg gcgcgcacaa gaggcggagc atgcggatta 720
attagatgca acgcgaagaa cctcacctgg gcttgacatg ttctcgacgg tagtagagat 780
acggcttccc ttcggggcgg gttcacaggt ggtgcatggt cgtcgtcagc tcgtgtcgtg 840
agatgttggg ttaagtcccg caacgagcgc aaccctcgcc ccgtgttgcc agcggattat 900
gccgggaact cacgggggac cgccggggtt aactcggagg aaggtgggga ggacgtcaga 960
tcatcatgcc cctcacgtcc agggcttcac gcatgctaca atggccggta caacgggatg 1020
cgacgcggtg acgcggagcg gatcccccaa aaccggtctc agttcggatc gcagtatgca 1080
actcgactgc gcgaaggcgg agtcgctagt aatcgcgaat cagcaacgtc gcggtgaatg 1140
cgttcccggg ccttgtacac accgcccgcc aagtcagaaa gaggcagcac ccgaagccgg 1200
tgcctaaccc ctgtggaggg agccgtctaa ggtaggctcg gt 1242
<210> 102
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 102
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca agcttgcttg gtggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ttccagttga tcgcatggtc ttctgggaaa gctttcgcgg tatgggatgg ggtcgcgtcc 240
tatcagcttg acggcggggt aacggcccac cgtggcttcg acgggtagcc ggcctgagag 300
ggcgaccggc cacattggga ctgagatacg gcccagactc ctacgggagg cagcagtggg 360
gaatattgca caatgggcgc aagcctgatg cagcgacgcc gcgtgaggga tggaggcctt 420
cgggttgtaa acctctttta tcggggagca agcgtgagtg agtttacccg ttgaataagc 480
accggctaac tacgtgccag cagccgcggt aatacgtagg gtgcaagcgt tatccggaat 540
tattgggcgt aaagggctcg taggcggttc gtcgcgtccg gtgtgaaagt ccatcgctta 600
acggtggatc cgcgccgggt acgggcgggc ttgagtgcgg taggggagac tggaattccc 660
ggtgtaacgg tggaatgtgt agatatcggg aagaacacca atggcgaagg caggtctctg 720
ggccgttact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 780
agtccacgcc gtaaacggtg gatgctggat gtggggcccg ttccacgggt tccgtgtcgg 840
agctaacgcg ttaagcatcc cgcctgggga gtacggccgc aaggctaaaa ctcaaagaaa 900
ttgacggggg cccgcacaag cggcggagca tgcggattaa ttcgatgcaa cgcgaagaac 960
cttacctggg cttgacatgt tcccgacgat cccagagatg gggtttccct tcggggcggg 1020
ttcacaggtg gtgcatggtc gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 1080
aacgagcgca accctcgccc cgtgttgcca gcggattgtg ccgggaactc acgggggacc 1140
gccggggtta actcggagga aggtggggat gacgtcagat catcatgccc cttacgtcca 1200
gggcttcacg catgctacaa tggccggtac aacgggatgc gacgcggcga cgcggagcgg 1260
atccctgaaa accggtctca gttcggatcg cagtctgcaa ctcgactgcg tgaaggcgga 1320
gtcgctagta atcgcgaatc agcaacgtcg cggtgaatgc gttcccgggc cttgtacaca 1380
ccgcccgtca agtcatgaaa gtgggcagca cccgaagccg gtggcctaac cccttgtggg 1440
atggagccgt ctaaggtgag gctcgtgatt gggactaagt cgtaacaagg tagccgtacc 1500
ggaaggtgcg gctggatcac ctcctttct 1529
<210> 103
<211> 1330
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 103
agtcgacggg atccatcaag cttgcttggt ggtgagagtg gcgaacgggt gagtaatgcg 60
tgaccgacct gccccataca ccggaatagc tcctggaaac gggtggtaat gccggatgct 120
ccagttgatc gcatggtctt ctgggaaagc tttcgcggta tgggatgggg tcgcgtccta 180
tcagcttgac ggcggggtaa cggcccaccg tggcttcgac gggtagccgg cctgagaggg 240
cgaccggcca cattgggact gagatacggc ccagactcct acgggaggca gcagtgggga 300
atattgcaca atgggcgcaa gcctgatgca gcgacgccgc gtgagggatg gaggccttcg 360
ggttgtaaac ctcttttatc ggggagcaag cgagagtgag tttacccgtt gaataagcac 420
cggctaacta cgtgccagca gccgcggtaa tacgtagggt gcaagcgtta tccggaatta 480
ttgggcgtaa agggctcgta ggcggttcgt cgcgtccggt gtgaaagtcc atcgcttaac 540
ggtggatccg cgccgggtac gggcgggctt gagtgcggta ggggagactg gaattcccgg 600
tgtaacggtg gaatgtgtag atatcgggaa gaacaccaat ggcgaaggca ggtctctggg 660
ccgttactga cgctgaggag cgaaagcgtg gggagcgaac aggattagat accctggtag 720
tccacgccgt aaacggtgga tgctggatgt ggggcccgtt ccacgggttc cgtgtcggag 780
ctaacgcgtt aagcatcccg cctggggagt acggccgcaa ggctaaaact caaagaaatt 840
gacgggggcc cgcacaagcg gcggagcatg cggattaatt cgatgcaacg cgaagaacct 900
tacctgggct tgacatgttc ccgacggtcg tagagatacg gcttcccttc ggggcgggtt 960
cacaggtggt gcatggtcgt cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa 1020
cgagcgcaac cctcgccccg tgttgccagc ggattatgcc gggaactcac gggggaccgc 1080
cggggttaac tcggaggaag gtggggatga cgtcagatca tcatgcccct tacgtccagg 1140
gcttcacgca tgctacaatg gccggtacaa cgggatgcga cgcggcgacg cggagcggat 1200
ccctgaaaac cggtctcagt tcggatcgca gtctgcaact cgactgcgtg aaggcggagt 1260
cgctagtaat cgcgaatcag caacgtcgcg gtgaatgcgt tcccgggcct tgtacacacc 1320
gcccgtcaag 1330
<210> 104
<211> 1518
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 104
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gggatccatc aggctttgct tggtggcgag agtggcgaac gggtgagtaa tgcgtgaccg 120
acctgcccca tacaccggaa tagctcctgg aaacgggtgg taatgccgga tgctccagtt 180
gatcgcatgg tcttctggga aagctttcgc ggtatgggat ggggccgcgt cctatcagct 240
tgacggcggg gtaacggccc accgtggctt cgacgggtag ccggcctgag agggcgaccg 300
gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg gggaatattg 360
cacaatgggc gcaagcctga tgcagcgacg ccgcgtgagg gatggaggcc ttcgggttgt 420
aaacctcttt tatcggggag caagcgagag tgagtttacc cgttgaataa gcaccggcta 480
actacgtgcc agcagccgcg gtaatacgta gggtgcaagc gttatccgga attattgggc 540
gtaaagggct cgtaggcggt tcgtcgcgtc cggtgtgaaa gtccatcgct taacggtgga 600
tccgcgccgg gtacgggcgg gcttgagtgc ggtaggggag actggaattc ccggtgtaac 660
ggtggaatgt gtagatatcg ggaagaacac caatggcgaa ggcaggtctc tgggccgtta 720
ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg gtagtccacg 780
ccgtaaacgg tggatgctgg atgtggggcc cgttccacgg gttccgtgtc ggagctaacg 840
cgttaagcat cccgcctggg gagtacggcc gcaaggctaa aactcaaaga aattgacggg 900
ggcccgcaca agcggcggag catgcggatt aattcgatgc aacgcgaaga accttacctg 960
ggcttgacat gttctcgacg gtcgtagaga tgcggcttcc cttcggggcg ggttcacagg 1020
tggtgcatgg tcgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg 1080
caaccctcgc cccgtgttgc cagcggatta tgccgggaac tcacggggga ccgccggggt 1140
taactcggag gaaggtgggg atgacgtcag atcatcatgc cccttacgtc cagggcttca 1200
cgcatgctac aatggccggt acaacgggat gcgacgcggc gacgcggagc ggatccctga 1260
aaaccggtct cagttcggat cgcagtctgc aactcgactg cgtgaaggcg gagtcgctag 1320
taatcgcgaa tcagcaacgt cgcggtgaat gcgttcccgg gccttgtaca caccgcccgt 1380
caagtcatga aagtgggcag cacccgaagc cggtggccta accccttgtg ggatggagcc 1440
gtctaaggtg aggctcgtga ttgggactaa gtcgtaacaa ggtagccgta ccggaaggtg 1500
cggctggatc acctcctt 1518
<210> 105
<211> 1530
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 105
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat acaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccagttg atcgcatggt cttctgggaa agctttcgcg gtatgggatg gggtcgcgtc 240
ctatcagctt gacggcgggg taacggccca ccgtggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt atcggggagc aagcgagagt gagtttaccc gttgaataag 480
caccggctaa ctacgtgcca gcagccgcgg taatacgtag ggtgcaagcg ttatccggaa 540
ttattgggcg taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgctt 600
aacggtggat ccgcgccggg tacgggcggg cttgagtgcg gtaggggaga ctggaattcc 660
cggtgtaacg gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct 720
gggccgttac tgacgctgag gagcgaaagc gtggggagcg aacaggatta gataccctgg 780
tagtccacgc cgtaaacggt ggatgctgga tgtggggccc gttccacggg ttccgtgtcg 840
gagctaacgc gttaagcatc ccgcctgggg agtacggccg caaggctaaa actcaaagaa 900
attgacgggg gcccgcacaa gcggcggagc atgcggatta attcgatgca acgcgaagaa 960
ccttacctgg gcttgacatg ttcccgacgg ccgtagagat acggcttccc ttcggggcgg 1020
gttcacaggt ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aaccctcgcc ccgtgttgcc agcggattat gccgggaact cacgggggac 1140
cgccggggtt aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc 1200
agggcttcac gcatgctaca atggccggta caacgggatg cgacgcggcg acgcggagcg 1260
gatccctgaa aaccggtctc agttcggatc gcagtctgca actcgactgc gtgaaggcgg 1320
agtcgctagt aatcgcgaat cagcaacgtc gcggtgaatg cgttcccggg ccttgtacac 1380
accgcccgtc aagtcatgaa agtgggcagc acccgaagcc ggtggcctaa ccccttgtgg 1440
gatggagccg tctaaggtga ggctcgtgat tgggactaag tcgtaacaag gtagccgtac 1500
cggaaggtgc ggctggatca cctcctttct 1530
<210> 106
<211> 1530
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 106
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatcg ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat acaccggaat agctcctgga aacgggtggt aatgccggat 180
gttccagttg atcgcatggt cttctgggaa agctttcgcg gtatgggatg gggtcgcgtc 240
ctatcagctt gacggcgggg taacggccca ccgtggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt atcggggagc aagcgtgagt gagtttaccc gttgaataag 480
caccggctaa ctacgtgcca gcagccgcgg taatacgtag ggtgcaagcg ttatccggaa 540
ttattgggcg taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgctt 600
aacggtggat ccgcgccggg tacgggcggg cttgagtgcg gtaggggaga ctggaattcc 660
cggtgtaacg gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct 720
gggccgttac tgacgctgag gagcgaaagc gtggggagcg aacaggatta gataccctgg 780
tagtccacgc cgtaaacggt ggatgctgga tgtggggccc gttccacggg ttccgtgtcg 840
gagctaacgc gttaagcatc ccgcctgggg agtacggccg caaggctaaa actcaaagaa 900
attgacgggg gcccgcacaa gcggcggagc atgcggatta attcgatgca acgcgaagaa 960
ccttacctgg gcttgacatg ttcccgacga tcccagagat ggggtttccc ttcggggcgg 1020
gttcacaggt ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aaccctcgcc ccgtgttgcc agcggattgt gccgggaact cacgggggac 1140
cgccggggtt aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc 1200
agggcttcac gcatgctaca atggccggta caacgggatg cgacgcggcg acgcggagcg 1260
gatccctgaa aaccggtctc agttcggatc gcagtctgca actcgactgc gtgaaggcgg 1320
agtcgctagt aatcgcgaat cagcaacgtc gcggtgaatg cgttcccggg ccttgtacac 1380
accgcccgtc aagtcatgaa agtgggcagc acccgaagcc ggtggcctaa ccccttgtgg 1440
gatggagccg tctaaggtga ggctcgtgat tgggactaag tcgtaacaag gtagccgtac 1500
cggaaggtgc ggctggatca cctcctttct 1530
<210> 107
<211> 1536
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 107
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat acaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccagttg atcgcatggt cttctgggaa agctttcgcg gtatgggatg gggtcgcgtc 240
ctatcagctt gacggcgggg taacggccca ccgtggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt atcggggagc aagcgagagt gagtttaccc gttgaataag 480
caccggctaa ctacgtgcca gcagccgcgg taatacgtag ggtgcaagcg ttatccggaa 540
ttattgggcg taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgctt 600
aacggtggat ccgcgccggg tacgggcggg cttgagtgcg gtaggggaga ctggaattcc 660
cggtgtaacg gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct 720
gggccgttac tgacgctgag gagcgaaagc gtggggagcg aacaggatta gataccctgg 780
tagtccacgc cgtaaacggt ggatgctgga tgtggggccc gttccacggg ttccgtgtcg 840
gagctaacgc gttaagcatc ccgcctgggg agtacggccg caaggctaaa actcaaagaa 900
attgacgggg gcccgcacaa gcggcggagc atgcggatta attcgatgca acgcgaagaa 960
ccttacctgg gcttgacatg ttcccgacgg tcgtagagat acggcttccc ttcggggcgg 1020
gttcacaggt ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aaccctcgcc ccgtgttgcc agcggattat gccgggaact cacgggggac 1140
cgccggggtt aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc 1200
agggcttcac gcatgctaca atggccggta caacgggatg cgacgcggcg acgcggagcg 1260
gatccctgaa aaccggtctc agttcggatc gcagtctgca actcgactgc gtgaaggcgg 1320
agtcgctagt aatcgcgaat cagcaacgtc gcggtgaatg cgttcccggg ccttgtacac 1380
accgcccgtc aagtcatgaa agtgggcagc acccgaagcc ggtggcctaa ccccttgtgg 1440
gatggagccg tctaaggtga ggctcgtgat tgggactaag tcgtaacaag gtagccgtac 1500
cggaaggtgc ggctggatca cctcctttct acggag 1536
<210> 108
<211> 1362
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 108
ttgcttggtg gtgagagtgg cgaacgggtg agtaatgcgt gaccgacctg ccccatacac 60
cggaatagct cctggaaacg ggtggtaatg ccggatgttc cagttgatcg catggtcttc 120
tgggaaagct ttcgcggtat gggatggggt cgcgtcctat cagcttgacg gcggggtaac 180
ggcccaccgt ggcttcgacg ggtagccggc ctgagagggc gaccggccac attgggactg 240
agatacggcc cagactccta cgggaggcag cagtggggaa tattgcacaa tgggcgcaag 300
cctgatgcag cgacgccgcg tgagggatgg aggccttcgg gttgtaaacc tcttttatcg 360
gggagcaagc gwgagtgagt ttacccgttg aataagcacc ggctaactac gtgccagcag 420
ccgcggtaat acgtagggtg caagcgttat ccggaattat tgggcgtaaa gggctcgtag 480
gcggttcgtc gcgtccggtg tgaaagtcca tcgcttaacg gtggatccgc gccgggtacg 540
ggcgggcttg agtgcggtag gggagactgg aattcccggt gtaacggtgg aatgtgtaga 600
tatcgggaag aacaccaatg gcgaaggcag gtctctgggc cgttactgac gctgaggagc 660
gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta aacggtggat 720
gctggatgtg gggcccgttc cacgggttcc gtgtcggagc taacgcgtta agcatcccgc 780
ctggggagta cggccgcaag gctaaaactc aaagaaattg acgggggccc gcacaagcgg 840
cggagcatgc ggattaattc gatgcaacgc gaagaacctt acctgggctt gacatgttcc 900
cgacgrtcsy agagatgggg yttcccttcg gggcgggttc acaggtggtg catggtcgtc 960
gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac gagcgcaacc ctcgccccgt 1020
gttgccagcg gattrtgccg ggaactcacg ggggaccgcc ggggttaact cggaggaagg 1080
tggggatgac gtcagatcat catgcccctt acgtccaggg cttcacgcat gctacaatgg 1140
ccggtacaac gggatgcgac gcggcgacgc ggagcggatc cctgaaaacc ggtctcagtt 1200
cggatcgcag tctgcaactc gactgcgtga aggcggagtc gctagtaatc gcgaatcagc 1260
aacgtcgcgg tgaatgcgtt cccgggcctt gtacacaccg cccgtcaagt catgaaagtg 1320
ggcagcaccc gaagccggtg gcctaacccc ttgtgggatg ga 1362
<210> 109
<211> 1530
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 109
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat acaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccagttg atcgcatggt cttctgggaa agctttcgcg gtatgggatg gggtcgcgtc 240
ctatcagctt gacggcgggg taacggccca ccgtggcttc gacgggtagc cggcctgaga 300
gggcgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct 420
tcgggttgta aacctctttt atcggggagc aagcgagagt gagtttaccc gttgaataag 480
caccggctaa ctacgtgcca gcagccgcgg taatacgtag ggtgcaagcg ttatccggaa 540
ttattgggcg taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgctt 600
aacggtggat ccgcgccggg tacgggcggg cttgagtgcg gtaggggaga ctggaattcc 660
cggtgtaacg gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct 720
gggccgttac tgacgctgag gagcgaaagc gtggggagcg aacaggatta gataccctgg 780
tagtccacgc cgtaaacggt ggatgctgga tgtggggccc gttccacggg ttccgtgtcg 840
gagctaacgc gttaagcatc ccgcctgggg agtacggccg caaggctaaa actcaaagaa 900
attgacgggg gcccgcacaa gcggcggagc atgcggatta attcgatgca acgcgaagaa 960
ccttacctgg gcttgacatg ttcccgacgg tcgtagagat acggcttccc ttcggggcgg 1020
gttcacaggt ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aaccctcgcc ccgtgttgcc agcggattat gccgggaact cacgggggac 1140
cgccggggtt aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc 1200
agggcttcac gcatgctaca atggccggta caacgggatg cgacgcggcg acgcggagcg 1260
gatccctgaa aaccggtctc agttcggatc gcagtctgca actcgactgc gtgaaggcgg 1320
agtcgctagt aatcgcgaat cagcaacgtc gcggtgaatg cgttcccggg ccttgtacac 1380
accgcccgtc aagtcatgaa agtgggcagc acccgaagcc ggtggcctaa ccccttgtgg 1440
gatggagccg tctaaggtga ggctcgtgat tgggactaag tcgtaacaag gtagccgtac 1500
cggaaggtgc ggctggatca cctcctttct 1530
<210> 110
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 110
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca agcttgcttg gtggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta atgccggatg 180
ttccagttga tcgcatggtc ttctgggaaa gctttcgcgg tatgggatgg ggtcgcgtcc 240
tatcagcttg acggcggggt aacggcccac cgtggcttcg acgggtagcc ggcctgagag 300
ggcgaccggc cacattggga ctgagatacg gcccagactc ctacgggagg cagcagtggg 360
gaatattgca caatgggcgc aagcctgatg cagcgacgcc gcgtgaggga tggaggcctt 420
cgggttgtaa acctctttta tcggggagca agcgagagtg agtttacccg ttgaataagc 480
accggctaac tacgtgccag cagccgcggt aatacgtagg gtgcaagcgt tatccggaat 540
tattgggcgt aaagggctcg taggcggttc gtcgcgtccg gtgtgaaagt ccatcgctta 600
acggtggatc cgcgccgggt acgggcgggc ttgagtgcgg taggggagac tggaattccc 660
ggtgtaacgg tggaatgtgt agatatcggg aagaacacca atggcgaagg caggtctctg 720
ggccgttact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 780
agtccacgcc gtaaacggtg gatgctggat gtggggcccg ttccacgggt tccgtgtcgg 840
agctaacgcg ttaagcatcc cgcctgggga gtacggccgc aaggctaaaa ctcaaagaaa 900
ttgacggggg cccgcacaag cggcggagca tgcggattaa ttcgatgcaa cgcgaagaac 960
cttacctggg cttgacatgt tcccgacggt cgtagagata cggcttccct tcggggcggg 1020
ttcacaggtg gtgcatggtc gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 1080
aacgagcgca accctcgccc cgtgttgcca gcggattatg ccgggaactc acgggggacc 1140
gccggggtta actcggagga aggtggggat gacgtcagat catcatgccc cttacgtcca 1200
gggcttcacg catgctacaa tggccggtac aacgggatgc gacgcggcga cgcggagcgg 1260
atccctgaaa accggtctca gttcggatcg cagtctgcaa ctcgactgcg tgaaggcgga 1320
gtcgctagta atcgcgaatc agcaacgtcg cggtgaatgc gttcccgggc cttgtacaca 1380
ccgcccgtca agtcatgaaa gtgggcagca cccgaagccg gtggcctaac cccttgtggg 1440
atggagccgt ctaaggtgag gctcgtgatt gggactaagt cgtaacaagg tagccgtacc 1500
ggaaggtgcg gctggatcac ctcctttct 1529
<210> 111
<211> 1514
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 111
agggttcgat tctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gggatccatc aggctttgct tggtggtgag agtggcgaac gggtgagtaa tgcgtgaccg 120
acctgcccca tacaccggaa tagctcctgg aaacgggtgg taatgccgga tgctccagtt 180
gatcgcatgg tcttctggga aagctttcgc ggtatgggat ggggtcgcgt cctatcagct 240
tgacggcggg gtaacggccc accgtggctt cgacgggtag ccggcctgag agggcgaccg 300
gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg gggaatattg 360
cacaatgggc gcaagcctga tgcagcgacg ccgcgtgagg gatggaggcc ttcgggttgt 420
aaacctcttt tatcggggag caagcgagag tgagtttacc cgttgaataa gcaccggcta 480
actacgtgcc agcagccgcg gtaatacgta gggtgcaagc gttatccgga attattgggc 540
gtaaagggct cgtaggcggt tcgtcgcgtc cggtgtgaaa gtccatcgct taacggtgga 600
tccgcgccgg gtacgggcgg gcttgagtgc ggtaggggag actggaattc ccggtgtaac 660
ggtggaatgt gtagatatcg ggaagaacac caatggcgaa ggcaggtctc tgggccgtta 720
ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg gtagtccacg 780
ccgtaaacgg tggatgctgg atgtggggcc cgttccacgg gttccgtgtc ggagctaacg 840
cgttaagcat cccgcctggg gagtacggcc gcaaggctaa aactcaaaga aattgacggg 900
ggcccgcaca agcggcggag catgcggatt aattcgatgc aacgcgaaga accttacctg 960
ggcttgacat gttcccgacg gtcgtagaga tacggcttcc cttcggggcg ggttcacagg 1020
tggtgcatgg tcgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg 1080
caaccctcgc cccgtgttgc cagcggatta tgccgggaac tcacggggga ccgccggggt 1140
taactcggag gaaggtgggg atgacgtcag atcatcatgc cccttacgtc cagggcttca 1200
cgcatgctac aatggccggt acaacgggat gcgacgcggc gacgcggagc ggatccctga 1260
aaaccggtct cagttcggat cgcagtctgc aactcgactg cgtgaaggcg gagtcgctag 1320
taatcgcgaa tcagcaacgt cgcggtgaat gcgttcccgg gccttgtaca caccgcccgt 1380
caagtcatga aagtgggcag cacccgaagc cggtggccta accccttgtg ggatggagcc 1440
gtctaaggtg aggctcgtga ttgggactaa gtcgtaacaa ggtagccgta ccggaaggtg 1500
cggctggatc acct 1514
<210> 112
<211> 1506
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_longum
<400> 112
gggtttcgat tctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gggatccatc aagcttgctt ggtggtgaga gtggcgaacg ggtgagtaat gcgtgaccga 120
cctgccccat acaccggaat agctcctgga aacgggtggt aatgccggat gttccagttg 180
atcgcatggt cttctgggaa agctttcgcg gtatgggatg gggtcgcgtc ctatcagctt 240
gacggcgggg taacggccca ccgtggcttc gacgggtagc cggcctgaga gggcgaccgg 300
ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg ggaatattgc 360
acaatgggcg caagcctgat gcagcgacgc cgcgtgaggg atggaggcct tcgggttgta 420
aacctctttt atcggggagc aagcgtgagt gagtttaccc gttgaataag caccggctaa 480
ctacgtgcca gcagccgcgg taatacgtag ggtgcaagcg ttatccggaa ttattgggcg 540
taaagggctc gtaggcggtt cgtcgcgtcc ggtgtgaaag tccatcgctt aacggtggat 600
ccgcgccggg tacgggcggg cttgagtgcg gtaggggaga ctggaattcc cggtgtaacg 660
gtggaatgtg tagatatcgg gaagaacacc aatggcgaag gcaggtctct gggccgttac 720
tgacgctgag gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc 780
cgtaaacggt ggatgctgga tgtggggccc gttccacggg ttccgtgtcg gagctaacgc 840
gttaagcatc ccgcctgggg agtacggccg caaggctaaa actcaaagaa attgacgggg 900
gcccgcacaa gcggcggagc atgcggatta attcgatgca acgcgaagaa ccttacctgg 960
gcttgacatg ttcccgacgg ccgtagagat acggcttccc ttcggggcgg gttcacaggt 1020
ggtgcatggt cgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc 1080
aaccctcgcc ccgtgttgcc agcggattgt gccgggaact cacgggggac cgccggggtt 1140
aactcggagg aaggtgggga tgacgtcaga tcatcatgcc ccttacgtcc agggcttcac 1200
gcatgctaca atggccggta caacgggatg cgacgcggcg acgcggagcg gatccctgaa 1260
aaccggtctc agttcggatc gcagtctgca actcgactgc gtgaaggcgg agtcgctagt 1320
aatcgcgaat cagcaacgtc gcggtgaatg cgttcccggg ccttgtacac accgcccgtc 1380
aagtcatgaa agtgggcagc acccgaagcc ggtggcctaa ccccttgcgg gagggagccg 1440
tctaaggtga ggctcgtgat tgggactaag tcgtaacaag gtagccgtac cggaaggtgc 1500
ggctgg 1506
<210> 113
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_pseudocatenulatum
<400> 113
tttttgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatccatca ggctttgctt ggtggtgaga gtggcgaacg ggtgagtaat 120
gcgtgaccga cctgccccat acaccggaat agctcctgga aacgggtggt aatgccggat 180
gctccgactc ctcgcatggg gtgtcgggaa agatttcatc ggtatgggat ggggtcgcgt 240
cctatcaggt agtcggcggg gtaacggccc accgagccta cgacgggtag ccggcctgag 300
agggcgaccg gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg 360
gggaatattg cacaatgggc gcaagcctga tgcagcgacg ccgcgtgcgg gatgacggcc 420
ttcgggttgt aaaccgcttt tgatcgggag caagccttcg ggtgagtgta cctttcgaat 480
aagcaccggc taactacgtg ccagcagccg cggtaatacg tagggtgcaa gcgttatccg 540
gaattattgg gcgtaaaggg ctcgtaggcg gttcgtcgcg tccggtgtga aagtccatcg 600
cttaacggtg gatctgcgcc gggtacgggc gggctggagt gcggtagggg agactggaat 660
tcccggtgta acggtggaat gtgtagatat cgggaagaac accaatggcg aaggcaggtc 720
tctgggccgt tactgacgct gaggagcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg cccgttccac gggttccgtg 840
tcggagctaa cgcgttaagc atcccgcctg gggagtacgg ccgcaaggct aaaactcaaa 900
gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa 960
gaaccttacc tgggcttgac atgttcccga cagccgtaga gatatggcct cccttcgggg 1020
cgggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctc gccctgtgtt gccagcacgt catggtggga actcacgggg 1140
ggaccgccgg ggtcaactcg gaggaaggtg gggatgacgt cagatcatca tgccccttac 1200
gtccagggct tcacgcatgc tacaatggcc ggtacaacgg gatgcgacac ggcgacgtgg 1260
agcggatccc tgaaaaccgg tctcagttcg gattggagtc tgcaacccga ctccatgaag 1320
gcggagtcgc tagtaatcgc ggatcagcaa cgccgcggtg aatgcgttcc cgggccttgt 1380
acacaccgcc cgtcaagtca tgaaagtggg tagcacccga agccggtggc ctaacccttt 1440
gtggatggag ccgtctaagg tgagactcgt gattgggact aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga tcacctcctt tct 1533
<210> 114
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_pseudolongum
<220>
<221> misc_feature
<222> (1526)..(1526)
<223> n is a, c, g, or t
<400> 114
ttcgattctg gctcaggatg aacgctggcg gcgtgcttaa cacatgcaag tcgaacggga 60
tccctggcag cttgctgccg gggtgagagt ggcgaacggg tgagtaatgc gtgaccgacc 120
tgccccatgc accggaatag ctcctggaaa cgggtggtaa tgccggatgt tccacatgag 180
cgcatgcgag tgtgggaaag gcttttgcgg catgggatgg ggtcgcgtcc tatcagcttg 240
ttggtggggt aacggcctac caaggcgttg acgggtagcc ggcctgagag ggcgaccggc 300
cacattggga ctgagatacg gcccagactc ctacgggagg cagcagtggg gaatattgca 360
caatgggcgc aagcctgatg cagcgacgcc gcgtgcggga tggaggcctt cgggttgtaa 420
accgcttttg ttcaagggca aggcacggtt tcggccgtgt tgagtggatt gttcgaataa 480
gcaccggcta actacgtgcc agcagccgcg gtaatacgta gggtgcaagc gttatccgga 540
tttattgggc gtaaagggct cgtaggcggt tcgtcgcgtc cggtgtgaaa gtccatcgct 600
taacggtgga tccgcgccgg gtacgggcgg gcttgagtgc ggtaggggag actggaattc 660
ccggtgtaac ggtggaatgt gtagatatcg ggaagaacac caatggcgaa ggcaggtctc 720
tgggccgtta ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg 780
gtagtccacg ccgtaaacgg tggatgctgg atgtggggcc ctttttccgg gtcctgtgtc 840
ggagctaacg cgttaagcat cccgcctggg gagtacggcc gcaaggctaa aactcaaaga 900
aattgacggg ggcccgcaca agcggcggag catgcggatt aattcgatgc aacgcgaaga 960
accttacctg ggcttgacat gtgcctgacg atcccggaga cggggtttcc cttcggggcg 1020
ggttcacagg tggtgcatgg tcgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caaccctcgc cgcgtgttgc cagcgggtca tgccgggaac tcacgtggga 1140
ccgccggggt taactcggag gaaggtgggg atgacgtcag atcatcatgc cccttacgtc 1200
cagggcttca cgcatgctac aatggccggt acaacggggt gcgacacggt gacgtggggc 1260
ggatccctga aaaccggtct cagttcggat cgcagtctgc aactcgactg cgtgaaggtg 1320
gagtcgctag taatcgcgga tcagcaacgc cgcggtgaat gcgttcccgg gccttgtaca 1380
caccgcccgt caagtcatga aagtgggcag cacccgaaga cggtggccta acccttgtgg 1440
ggggagccgt ctaaggtgag gctcgtgatt gggactaagt cgtaacaagg tagccgtacc 1500
ggaaggtgcg gctggatcac ctcctna 1527
<210> 115
<211> 1380
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_scardovii
<400> 115
gaacgctggc ggcgtgctta acacatgcaa gtcgaacggg atccggccag cttgctggtt 60
ggtgagagtg gcgaacgggt gagtaatgcg tgaccgacct gccccatgct ccggaatagc 120
tcctggaaac gggtggtaat gccggatggt ccagcatgct gcatggcgtg ttgggaaaga 180
tttatcggcg tgggatgggg tcgcgtccta tcagcttgac ggtggggtga tggcctaccg 240
tggcttcgac gggtagccgg cctgagaggg cgaccggcca cattgggact gagatacggc 300
ccagactcct acgggaggca gcagtgggga atattgcaca atgggcgcaa gcctgatgca 360
gcgacgccgc gtgagggatg gaggccttcg ggttgtaaac ctcttttagc agggagcaag 420
gcttcggttg agtgtacctg ttgaataagc accggctaac tacgtgccag cagccgcggt 480
aatacgtagg gtgcaagcgt tatccggaat tattgggcgt aaagggctcg taggcggttc 540
gtcgcgtctg gtgtgaaagt ccatcgctta acggtggatc tgcgccgggt acgggcgggc 600
tggagtgcgg taggggagac tggaattccc ggtgtaacgg tggaatgtgt agatatcggg 660
aagaacacca atggcgaagg caggtctctg ggccgttact gacgctgagg agcgaaagcg 720
tggggagcga acaggattag ataccctggt agtccacgcc gtaaacggtg gacgctggat 780
gtggggccca ttccacgggt tccgtgtcgg agctaacgcg ttaagcgtcc cgcctgggga 840
gtacggccgc aaggctaaaa ctcaaagaaa ttgacggggg cccgcacaag cggcggagca 900
tgcggattaa ttcgatgcaa cgcgaagaac cttacctggg cttgacatgt tcccgacggc 960
cccagagatg gggcttccct tcggggcggg ttcacaggtg gtgcatggtc gtcgtcagct 1020
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca accctcgccc cgtgttgcca 1080
gcattttgga tgggaactca cgggggaccg ccggggttaa ctcggaggaa ggtggggatg 1140
acgtcagatc atcatgcccc tacgtccagg gcttcacgca tgctacaatg gccggtacaa 1200
cgggatgcga catggcgaca tggagcggat ccctgaaaac cggtctcagt tcggattgga 1260
gtctgcaacc cgactccatg aaggcggagt cgctagtaat cgcgaatcag caacgtcgcg 1320
gtgaatgcgt tcccgggcct tgtacacacc gcccgtcaag tcatgaaagt gggcagcacc 1380
<210> 116
<211> 1363
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_sp_HM2
<400> 116
gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc aagtcgaacg 60
agtggcgaac gggtgagtaa tgcgtgaccg acctgcccca tgcaccggaa tagctcctgg 120
aaacgggtgg taatgccgga tgctgaaagg cggcatggga tggggtcgcg tcctatcagc 180
ttgatggcgg ggtaacggcc caccatggct tcgacgggta gccggcctga gagggcgacc 240
ggccacattg ggactgagat acggcccaga ctcctacggg aggcagcagt ggggaatatt 300
gcacaatggg cgcaagcctg atgcagcgac gccgcgtgcg ggatgacggc cttcgggttg 360
taaaccgctt ttgatcggga gcatgagtgt acctttcgaa taagcaccgg ctaactacgt 420
gccagcagcc gcggtaatac gtagggtgca agcgttatcc ggaattattg ggcgtaaagg 480
gctcgtaggc ggttcgtcgc gtccggtgtg aaagtccatc gcttaacggt ggatctgcgc 540
cgggtacggg cgggctggag tgcggtaggg gagactggaa ttcccggtgt aacggtggaa 600
tgtgtagata tcgggaagaa caccaatggc gaaggcaggt ctctgggccg actgacgctg 660
aggagcgaaa gcgtggggag cgaacaggat tagataccct ggtagtccac gccgtaaacg 720
gtggatgctg gatgtggggc gttccgtgtc ggagctaacg cgttaagcat cccgcctggg 780
gagtacggcc gcaaggctaa aactcaaaga aattgacggg ggcccgcaca agcggcggag 840
catgcggatt aattcgatgc aacgcgaaga accttacctg ggcttgacat gcacaggtgg 900
tgcatggtcg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 960
ccctcgccct gtgttgccag cacgtgggaa ctcacggggg accgccgggg tcaactcgga 1020
ggaaggtggg gatgacgtca gatcatcatg ccccttacgt ccagggcttc acgcatgcta 1080
caatggccgg caacgggatg cgacacggcg acgtggagcg gatccctgcc ggtctcagtt 1140
cggatggagt ctgcaacccg actccagaag gcggagtcgc tagtaatcgc ggatcagcaa 1200
cgccgcggtg aatgcgttcc cgggccttgt acacaccgcc cgtcaagtca tgaaagtggg 1260
tagcacccga agccggtgcc tatggagccg tctaaggtga gactcgtgat tgggactaag 1320
tcgtaacaag gtagccgtac cggaaggtgc ggctggatca cct 1363
<210> 117
<211> 1245
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_sp_HMLN12
<220>
<221> misc_feature
<222> (28)..(28)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (792)..(792)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1210)..(1210)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1217)..(1217)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1219)..(1219)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1228)..(1228)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1240)..(1241)
<223> n is a, c, g, or t
<400> 117
aacgggagag gatgcgtgac cgacctgncc catgcaccgg aatagctcct ggaaacgggt 60
ggtaatgccg gatgttccac atgagcgcat gcgagtgtgg gaaaggcttt tgcggcatgg 120
gatggggtcg cgtcctatca gcttgttggt ggggtaacgg cctaccaagg cgttgacggg 180
tagccggcct gagagggcga ccggccacat tgggactgag atacggccca gactcctacg 240
ggaggcagca gtggggaata ttgcacaatg ggcgcaagcc tgatgcagcg acgccgcgtg 300
cgggatggag gccttcgggt tgtaaaccgc ttttgttcaa gggcaaggca cggtttcggc 360
cgtgttgagt ggattgttcg aataagcacc ggctaactac gtgccagcag ccgcggtaat 420
acgtagggtg caagcgttat ccggatttat tgggcgtaaa gggctcgtag gcggttcgtc 480
gcgtccggtg tgaaagtcca tcgcttaacg gtggatccgc gccgggtacg ggcgggcttg 540
agtgcggtag gggagactgg aattcccggt gtaacggtgg aatgtgtaga tatcgggaag 600
aacaccaatg gcgaaggcag gtctctgggc cgttactgac gctgaggagc gaaagcgtgg 660
gaagcgaaca ggattagata ccctggtagt ccacgccgta aacggtggat gctggatgtg 720
gggccctttt tccgggtcct gtgtcggagc taacgcgtta agcatcccgc ctggggagta 780
cggccgcaag gntaaaactc aaagaaattg acgggggccc gcacaagcgg cggagcatgc 840
ggattaattc gatgcaacgc gaagaacctt acctgggctt gacatgtgcc tgacgatccc 900
ggagacgggg tttcccttcg gggcgggttc acaggtggtg catggtcgtc agctcgtgtc 960
gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctc gccgcgtgtt gccagcgggt 1020
catgccggga actcacgtgg gaccgccggg gttaactcgg aggaaggtgg ggatgacgtc 1080
agatcatcat gccccttacg tccagggctt cacgcatgct acaatggccg gtacaacggg 1140
gtgcgacacg gtgacgtggg gcggatccct gaaaaccggt ctcagttcgg atcgcagtct 1200
gcaactcgan tgctaangng cggagtcnct agtaatcgcn natca 1245
<210> 118
<211> 1405
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_sp_M45
<220>
<221> misc_feature
<222> (1215)..(1215)
<223> n is a, c, g, or t
<400> 118
gcttaccatg cagtcgaacg ggatcccagg agcttgctcc tgggtgagag tggcgaacgg 60
gtgagtaatg cgtgaccgac ctgccccata caccggaata gctcctggaa acgggtggta 120
atgccggatg ctccagttga atgcatgtcc ttctgggaaa gattttgcgg tatgggatgg 180
ggtcgcgtcc tatcagcttg atggcggggt aacggcccac catggcttcc acgggtagcc 240
ggcctgagag ggcgaccggc cacattggga ctgaaatacg gcccagactc ctacgggagg 300
cagcagtggg gaatattgca caatgggcgc aagcctgatg cagcgacgcc gcgtgcggga 360
tgacggcctt cgggttgtaa accgcttttg actgggagca agcccttcgg ggtgagtgta 420
cctttcgaat aagcaccggc taactacgtg ccagcagccg cggtaatacg tagggtgcaa 480
gcgttatccg gaattattgg gcgtaaaggg ctcgtaagcg gttcgtcgcg tccggtgtga 540
aagtccatcg cttaacggtg gatccgcgcc gggtacgggc gggcttgagt gcggtagggg 600
agactggaat tcccggtgta acggtggaat gtgtagatat cgggaagaac accaatggcg 660
aaggcaggtc tctgggccgt cactgacgct gaggagcgaa agcgtgggga gcgaacagga 720
ttagataccc tggtagtcca cgccgtaaac ggtggatgct ggatgtgggg accattccac 780
ggtctccgtg tcggagccaa cgcgttaagc atcccgcctg gggagtacgg ccgcaaggct 840
aaaactcaaa gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat 900
gcaacgcgaa gaaccttacc tgggcttgac atgttcccga cagccccaga gatggggcct 960
cccttcgggg cgggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt 1020
gggttaagtc ccgcaacgag cgcaaccctc gccctgtgtt gccagcacgt cgtggtggga 1080
actcacgggg gaccgccggg gtcaactcgg aggaaggtgg ggatgacgtc agatcatcat 1140
gccccttacg tccagggctt cacgcatgct acaatggccg gtacaacggg atgcgacact 1200
gtgaggtgga gcggntccct taaaaccggt ctcagttcgg attggagtct gcaacccgac 1260
tccatgaagg cggagtcgct agtaatcgcg gatcagcaac gccgcggtga atgcgttccc 1320
gggccttgta cacaccgccc gtcaagtcat gaaagtgggt agcacccgaa gccggtggcc 1380
caaccttttg ggggagccgt ctaag 1405
<210> 119
<211> 1267
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_sp_MSX5B
<400> 119
gctggcggcg tgcttaacac atgcaagtcg aacgagtggc gaacgggtga gtaatgcgtg 60
accgacctgc cccatacacc ggaatagctc ctggaaacgg gtggtaatgc cggatgctga 120
aagtcggtat gggatggggt cgcgtcctat cagcttgatg gcggggtaac ggcccaccat 180
ggcttcgacg ggtagccggc ctgagagggc gaccggccac attgggactg agatacggcc 240
cagactccta cgggaggcag cagtggggaa tattgcacaa tgggcgcaag cctgatgcag 300
cgacgccgcg tgcgggatga aggccttcgg gttgtaaacc gcttttgatc gggagcatga 360
gtgtaccctt cgaataagca ccggctaact acgtgccagc agccgcggta atacgtaggg 420
tgcaagcgtt atccggaatt attgggcgta aagggctcgt aggcggttcg tcgcgtccgg 480
tgtgaaagcc catcgcttaa cggtgggtct gcgccgggta cgggcgggct ggagtgcggt 540
aggggagact ggaattcccg gtgtaacggt ggaatgtgta gatatcggga agaacaccaa 600
tggcgaaggc aggtctctgg gccgactgac gctgaggagc gaaagcgtgg ggagcgaaca 660
ggattagata ccctggtagt ccacgccgta aacggtggat gctggatgtg gggcgttccg 720
tgtcggagct aacgcgttaa gcatcccgcc tggggagtac ggccgcaagg ctaaaactca 780
aagaaattga cgggggcccg cacaagcggc ggagcatgcg gattaattcg atgcaacgcg 840
aagaacctta cctgggcttg acatgcacag gtggtgcatg gtcgtcgtca gctcgtgtcg 900
tgagatgttg ggttaagtcc cgcaacgagc gcaaccctcg ccctgtgttg ccagcacgtg 960
ggaactcacg ggggaccgcc ggggtcaact cggaggaagg tggggatgac gtcagatcat 1020
catgcccctt acgtccaggg cttcacgcat gctacaatgg ccggcagcgg gatgcgacat 1080
ggcgacatgg agcggatccc tgccggtctc agttcggatg gagtctgcaa cccgactcca 1140
gaaggcggag tcgctagtaa tcgcggatca gcaacgccgc ggtgaatgcg ttcccgggcc 1200
ttgtacacac cgcccgtcaa gtcatgaaag tgggcagcac ccgaagccgg tgcctatgga 1260
gccgtct 1267
<210> 120
<211> 1303
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_sp_TM_7
<400> 120
tggctcagga tgaacgctgg cggcgtgctt aacacatgca agtcgaacga gtggcgaacg 60
ggtgagtaat gcgtgaccga cctgccccat acaccggaat agctcctgga aacgggtggt 120
aatgccggat gctgaaagtc ggtatgggat ggggtcgcgt cctatcagct tgatggcggg 180
gtaacggccc accatggctt cgacgggtag ccggcctgag agggcgaccg gccacattgg 240
gactgagata cggcccagac tcctacggga ggcagcagtg gggaatattg cacaatgggc 300
gcaagcctga tgcagcgacg ccgcgtgcgg gatgacggcc ttcgggttgt aaaccgcttt 360
tgactgggag catgagtgta cctttcgaat aagcaccggc taactacgtg ccagcagccg 420
cggtaatacg tagggtgcaa gcgttatccg gaattattgg gcgtaaaggg ctcgtaggcg 480
gttcgtcgcg tccggtgtga aagtccatcg cttaacggtg gatccgcgcc gggtacgggc 540
gggcttgagt gcggtagggg agactggaat tcccggtgta acggtggaat gtgtagatat 600
cgggaagaac accaatggcg aaggcaggtc tctgggccga ctgacgctga ggagcgaaag 660
cgtggggagc gaacaggatt agataccctg gtagtccacg ccgtaaacgg tggatgctgg 720
atgtggggat ctccgtgtcg gagccaacgc gttaagcatc ccgcctgggg agtacggccg 780
caaggctaaa actcaaagaa attgacgggg gcccgcacaa gcggcggagc atgcggatta 840
attcgatgca acgcgaagaa ccttacctgg gcttgacatg cacaggtggt gcatggtcgt 900
cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac cctcgccctg 960
tgttgccagc acgtgggaac tcacggggga ccgccggggt caactcggag gaaggtgggg 1020
atgacgtcag atcatcatgc cccttacgtc cagggcttca cgcatgctac aatggccggc 1080
aacgggatgc gacactgtga ggtggagcgg atcccttccg gtctcagttc ggatggagtc 1140
tgcaacccga ctccagaagg cggagtcgct agtaatcgcg gatcagcaac gccgcggtga 1200
atgcgttccc gggccttgta cacaccgccc gtcaagtcat gaaagtgggt agcacccgaa 1260
gccggtgccc agggagccgt ctaaggtgag actcgtgatt ggg 1303
<210> 121
<211> 1392
<212> DNA
<213> Artificial Sequence
<220>
<223> Bifidobacterium_thermophilum
<400> 121
tggctcagga tgaacgctgg cggcgtgctt aacacatgca agtcgaacgg gatcctgcaa 60
gcttgcttgc gggtgagagt ggcgaacggg tgagtaatgc gtgaccaacc tgccccatgc 120
tccggaatag ctcctggaaa cgggtggtaa tgccggatgt gccgggctcc tgcatggggg 180
tccgggaaag ctctggcggc gtgggatggg gtcgcgtcct atcagcttgt tggcggggtg 240
agggcccacc aaggcttcga cgggtagccg gcctgagagg gcgaccggcc acattgggac 300
tgagatacgg cccagactcc tacgggaggc agcagtgggg aatattgcac aatgggcgca 360
agcctgatgc agcgacgccg cgtgcgggat ggaggccttc gggttgtaaa ccgcttttgt 420
ttgggagcaa gcccttcggg gtgagtgtac ctttcgaata agcaccggct aactacgtgc 480
cagcagccgc ggtaatacgt agggtgcgag cgttatccgg atttattggg cgtaaagggc 540
tcgtaggcgg ttcgtcgcgt ccggtgtgaa agtccatcgc ctaacggtgg atctgcgccg 600
ggtacgggcg ggctggagtg cggtagggga gactggaatt cccggtgtaa cggtggaatg 660
tgtagatatc gggaagaaca ccaatggcga aggcaggtct ctgggccgtt actgacgctg 720
aggagcgaaa gcgtggggag cgaacaggat tagataccct ggtagtccac gccgtaaacg 780
gtggatgctg gatgtggggc ccttccacgg gtcccgtgtc ggagccaacg cgttaagcat 840
cccgcctggg gagtacggcc gcaaggctaa aactcaaaga aattgacggg ggcccgcaca 900
agcggcggag catgcggatt aattcgatgc aacgcgaaga accttacctg ggcttgacat 960
gttcccgacg acggcggaga cgtcgtttcc cttcggggcg ggttcacagg tggtgcatgg 1020
tcgtcgtcag ctcgtgtcgt gagatgttgg gtcaagtccc gcaacgagcg caaccctcgc 1080
cccgtgttgc cagcgcgtca tggcgggaac tcacggggga ccgccggggt taacccggga 1140
ggaaggtggg gatgacgtca gatcatcatg ccccttacgt ccagggcttc acgcatgcta 1200
caatggccgg tacaacggga tgcgacatgg cgacatggag cggatccctg aaaaccggtc 1260
tcagttcgga tcggagcctg caacccggct ccgtgaaggc ggagtcgcta gtaatcgcgg 1320
atcagcaacg ccgcggtgaa tgcgttcccg ggccttgtac acaccgcccg tcaagtcatg 1380
aaagtgggca gc 1392
<210> 122
<211> 1493
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_coccoides
<400> 122
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgagc 60
gaagcgctaa gacagatttc ttcggattga agtctttgtg actgagcggc ggacgggtga 120
gtaacgcgtg ggtaacctgc ctcatacagg gggataacag ttagaaatga ctgctaatac 180
cgcataagcg cacaggaccg catggtctgg tgtgaaaaac tccggtggta tgagatggac 240
ccgcgtctga ttagctagtt ggaggggtaa cggcccacca aggcgacgat cagtagccgg 300
cctgagaggg tgaacggcca cattgggact gagacacggc ccagactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcgacgccgc gtgaaggaag 420
aagtatctcg gtatgtaaac ttctatcagc agggaagaaa atgacggtac ctgactaaga 480
agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggcaag cgttatccgg 540
atttactggg tgtaaaggga gcgtagacgg aagagcaagt ctgatgtgaa aggctggggc 600
ttaaccccag gactgcattg gaaactgttg ttctagagtg ccggagaggt aagcggaatt 660
cctagtgtag cggtgaaatg cgtagatatt aggaggaaca ccagtggcga aggcggctta 720
ctggacggta actgacgttg aggctcgaaa gcgtggggag caaacaggat tagataccct 780
ggtagtccac gccgtaaacg atgaatacta ggtgtcgggt ggcaaagcca ttcggtgccg 840
cagcaaacgc aataagtatt ccacctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 960
ccttaccaag tcttgacatc cctctgaccg tcccgtaacg ggggcttccc ttcggggcag 1020
aggagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccttat ccttagtagc cagcacatga tggtgggcac tctagggaga 1140
ctgccgggga taacccggag gaaggcgggg acgacgtcaa atcatcatgc cccttatgat 1200
ttgggctaca cacgtgctac aatggcgtaa acaaagggaa gcgagacagc gatgttgagc 1260
gaatcccaaa aataacgtcc cagttcggac tgcagtctgc aactcgactg cacgaagctg 1320
gaatcgctag taatcgcgga tcagaatgcc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacctaa ccgaaaggaa 1440
ggagctgccg aaggcgggac cgataactgg ggtgaagtcg taacaaggta acc 1493
<210> 123
<211> 1491
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_glucerasea
<400> 123
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gagaaacatt ttaatgaagc ttcggcagat ttagtttgtt tctagtggcg gacgggtgag 120
taacgcgtgg gtaacctgcc tcacactggg ggataacagt cagaaatgac tgctaatacc 180
gcataagcgc acggaaccgc atggttttgt gtgaaaaact ccggtggtgt gagatggacc 240
cgcgttggat tagccagttg gcagggtaac ggcctaccaa agcgacgatc catagccggc 300
ctgagagggt gaacggccac attgggactg agacacggcc cagactccta cgggaggcag 360
cagtggggaa tattgcacaa tgggggaaac cctgatgcag cgacgccgcg tgaaggaaga 420
agtatctcgg tatgtaaact tctatcagca gggaagataa tgacggtacc tgactaagaa 480
gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc gttatccgga 540
tttactgggt gtaaagggag cgtagacgga gcagcaagtc tgatgtgaaa ggcaggggct 600
caacccctgg actgcattgg aaactgttga tcttgagtac cggaggggta agcggaattc 660
ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa ggcggcttac 720
tggacggtaa ctgacgttga ggctcgaaag cgtggggagc aaacaggatt agataccctg 780
gtagtccacg ccgtaaacga tgaatactag gtgtcgggtg gcagagccat tcggtgccgc 840
agcaaacgca gtaagtattc cacctgggga gtacgttcgc aagaatgaaa ctcaaaggaa 900
ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac 960
cttaccaagt cttgacatcc ctctgaccgg tccttaaccg gacctttcct tcgggacaga 1020
ggagacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aacccctatc cccagtagcc agcatttaag gtgggcactc tgaggagact 1140
gccagggata acctggagga aggcggggat gacgtcaaat catcatgccc cttatgattt 1200
gggctacaca cgtgctacaa tggcgtaaac aaagggaagc agagcggtga cgccgagcaa 1260
atcccaaaaa taacgtccca gttcggactg cagtctgcaa ctcgactgca cgaagctgga 1320
atcgctagta atcgcggatc agaatgccgc ggtgaatacg ttcccgggtc ttgtacacac 1380
cgcccgtcac accatgggag tcagtaacgc ccgaagtcag tgacctaacc gaaagggagg 1440
agctgccgaa ggcgggacgg atgactgggg tgaagtcgta acaaggtaac c 1491
<210> 124
<211> 1468
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_glucerasei
<220>
<221> misc_feature
<222> (990)..(990)
<223> n is a, c, g, or t
<400> 124
ctcaggatga acgctggcgg cgtgcttaac acatgcaagt cgaacgagaa acattttaat 60
gatagcttcg gcagatttag tttgtttcta gtggcggacg ggtgagtaac gcgtgggtaa 120
cctgcctcac actgggggat aacagtcaga aatgactgct aataccgcat aagcgcacgg 180
aaccgcatgg ttttgtgtga aaaactccgg tggtgtgaga tggacccgcg ttggattagc 240
cagttggcag ggtaacggcc taccaaagcg acgatccata gccggcctga gagggtgaac 300
ggccacattg ggactgagac acggcccaga ctcctacggg aggcagcagt ggggaatatt 360
gcacaatggg ggaaaccctg atgcagcgac gccgcgtgaa ggaagaagta tctcggtatg 420
taaacttcta tcagcaggga agataatgac ggtacctgac taagaagccc cggctaacta 480
cgtgccagca gccgcggtaa tacgtagggg gcaagcgtta tccggattta ctgggtgtaa 540
agggagcgta gacggagcag caagtctgat gtgaaaggca ggggctcaac ccctggactg 600
cattggaaac tgttgatctt gagtaccgga ggggtaagcg gaattcctag tgtagcggtg 660
aaatgcgtag atattaggag gaacaccagt ggcgaaggcg gcttactgga cggtaactga 720
cgttgaggct cgaaagcgtg gggagcaaac aggattagat accctggtag tccacgccgt 780
aaacgatgaa tactaggtgt cgggtggcag agccattcgg tgccgcagca aacgcagtaa 840
gtattccacc tggggagtac gttcgcaaga atgaaactca aaggaattga cggggacccg 900
cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccagagtctt 960
gacatccctc tgaccggtcc ttaaccggan ctttccttcg ggacagagga gacaggtggt 1020
gcatggttgt cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac 1080
ccctatcccc agtagccagc atttaaggtg ggcactctga ggagactgcc agggataacc 1140
tggaggaagg cggggatgac gtcaaatcat catgcccctt atgatttggg ctacacacgt 1200
gctacaatgg cgtaaacaaa gggaagcaga gcggtgacgc cgagcaaatc ccaaaaataa 1260
cgtcccagtt cggactgcag tctgcaactc gactgcacga agctggaatc gctagtaatc 1320
gcggatcaga atgccgcggt gaatacgttc ccgggtcttg tacacaccgc ccgtcacacc 1380
atgggagtca gtaacgcccg aagtcagtga cctaaccgaa agggaggagc tgccgaaggc 1440
gggacggatg actggggtga agtcgaac 1468
<210> 125
<211> 1157
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_hansenii
<400> 125
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgagc 60
gaagcactta tcattgactc ttcggaagat ttgatatttg actgagcggc ggacgggtga 120
gtaacgcgtg ggtaacctgc ctcatacagg ggaataacag ttagaaatgg ctgctaatgc 180
cgcataagcg cacaggatcg catggtctgg tgtgaaaaac tgaggtggta tgagatggac 240
ccgcgtctga ttaggtagtt ggtggggtaa cggcctacca agccgacgat cagtagccgg 300
cctgagaggg tgaacggcca cattgggact gagacacggc ccagactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcgacgccgc gtgaaggaag 420
aagtatctcg gtatgtaaac ttctatcagc agggaagaaa atgacggtac ctgactaaga 480
agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggcaag cgttatccgg 540
atttactggg tgtaaaggga gcgtagacgg aagagcaagt ctgatgtgaa aggctggggc 600
ttaaccccag gactgcattg gaaactgttt ttctagagtg ccggagaggt aagcggaatt 660
cctagtgtag cggtgaaatg cgtagatatt aggaggaaca ccagtggcga aggcggctta 720
ctggacggta actgacgttg aggctcgaaa gcgtggggag caaacaggat tagataccct 780
ggtagtccac gccgtaaacg atgaatacta ggtgtcgggg tgcaaagcag ttcggtgccg 840
cagcaaacgc aataagtatt ccacctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 960
ccttaccaag tcttgacatc tgcctgaccg ttccttgacc ggagctttcc ttcgggacag 1020
gcaagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccctat ccttagtagc cagcagttcg gctgggcact ctagggagac 1140
tgccggggat aacccgg 1157
<210> 126
<211> 1530
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_hydrogenotrophica
<400> 126
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcgata gagaacggag atttcggttg aagttttcta ttgactgagt ggcggacggg 120
tgagtaacgc gtgggtaacc tgccctatac agggggataa cagttagaaa tgactgctaa 180
taccgcataa gcgcacagct tcgcatgaag cggtgtgaaa aactgaggtg gtataggatg 240
gacccgcgtt ggattagcta gttggtgagg taacggccca ccaaggcgac gatccatagc 300
cggcctgaga gggtgaacgg ccacattggg actgagacac ggcccaaact cctacgggag 360
gcagcagtgg ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgaagg 420
aagaagtatc tcggtatgta aacttctatc agcagggaag aaagtgacgg tacctgacta 480
agaagccccg gctaattacg tgccagcagc cgcggtaata cgtaaggggc aagcgttatc 540
cggatttact gggtgtaaag ggagcgtaga cggtttggca agtctgatgt gaaaggcatg 600
ggctcaacct gtggactgca ttggaaactg tcagacttga gtgccggaga ggcaagcgga 660
attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaaggcggc 720
ctgctggacg gtaactgacg ttgaggctcg aaagcgtggg gagcaaacag gattagatac 780
cctggtagtc cacgctgtaa acgatgaata ctaggtgtcg ggtggcaaag ccattcggtg 840
ccgcagcaaa cgcaataagt attccacctg gggagtacgt tcgcaagaat gaaactcaaa 900
ggaattgacg gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc aaatcttgac atccctctga ccgggaagta atgttccctt ttcttcggaa 1020
cagaggagac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct tattcttagt agccagcagg tagagctggg cactctaggg 1140
agactgccag ggataacctg gaggaaggtg gggatgacgt caaatcatca tgccccttat 1200
gatttgggct acacacgtgc tacaatggcg taaacaaagg gaagcgaagg ggtgacctgg 1260
agcaaatctc aaaaataacg tctcagttcg gattgtagtc tgcaactcga ctacatgaag 1320
ctggaatcgc tagtaatcgc gaatcagaat gtcgcggtga atacgttccc gggtcttgta 1380
cacaccgccc gtcacaccat gggagtcagt aacgcccgaa gtcagtgacc caaccgaaag 1440
gagggagctg ccgaaggtgg gactgataac tggggtgaag tcgtaacaag gtagccgtat 1500
cggaaggtgc ggctggatca cctcctttct 1530
<210> 127
<211> 1481
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_luti
<400> 127
ctggctcagg atgaacgctg gcggcgtgct taacacatgc aagtcgaacg ggaawtattt 60
tattgaaact tcggtsgatt taatttaatt ctagtggcgg acgggtgagt aacgcgtggg 120
taacctgcct tatacagggg gataacagtc agaaatgact gctaataccg cataagcgca 180
cagagctgca tggctcagtg tgaaaaactc cggtggtata agatggaccc gcgttggatt 240
agctrgttgg tggggtaacg gcccaccaag gcgacgatcc atagccggcc tgagagggtg 300
aacggccaca ttgggactga gacacggccc agactcctac gggaggcagc agtggggaat 360
attgcacaat gggggaaacc ctgatgcagc gacgccgcgt gaaggaagaa gtatctcggt 420
atgtaaactt ctatcagcag ggaagatagt gacggtacct gactaagaag ccccggctaa 480
ctacgtgcca gcagccgcgg taatacgtag ggggcaagcg ttatccggat ttactgggtg 540
taaagggagc gtagacggtg tggcaagtct gatgtgaaag gcatgggctc aacctgtgga 600
ctgcattgga aactgycata cttgagtgcc ggaggggtaa gcggaattcc tagtgtagcg 660
gtgaaatgcg tagatattag gaggaacacc agtggcgaag gcggcttact ggacggtaac 720
tgacgttgag gctcgaaagc gtggggagca aacaggatta gataccctgg tagtccacgc 780
cgtaaacgat gaatactagg tgtcggggag catggctctt cggtgccgtc gcaaacgcag 840
taagtattcc acctggggag tacgttcgca agaatgaaac tcaaaggaat tgacggggac 900
ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaaatc 960
ttgacatccc tctgaccggt ctttaatcgg acctttcctt cgggacaggg gagacaggtg 1020
gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 1080
acccctatcc tcagtagcca gcaagttaag ttgggcactc tgtggagact gccagggata 1140
acctggagga aggcggggat gacgtcaaat catcatgccc cttatgattt gggctacaca 1200
cgtgctacaa tggcgtaaac aaagggaagc gagakkgtga satggagcaa atcccaaaaa 1260
taacgtccca gttcggactg tagtctgcaa cccgactaca cgaagctgga atcgctagta 1320
atcgcggatc agaatgccgc ggtgaatacg ttcccgggtc ttgtacacac cgcccgtcac 1380
accatgggag tcagtaacgc ccgaagtcag tgacctaacc gaaagggagg agctgccgaa 1440
ggcgggaccg atgactgggg tgaagtcgta acaaggtaac c 1481
<210> 128
<211> 1493
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_producta
<400> 128
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgagc 60
gaagcactaa gacggatttc ttcggattga agtctttgtg actgagcggc ggacgggtga 120
gtaacgcgtg ggtaacctgc ctcatacagg gggataacag ttagaaatga ctgctaatac 180
cgcataagcg cacaggaccg catggtctgg tgtgaaaaac tccggtggta tgagatggac 240
ccgcgtctga ttagctagtt ggaggggtaa cggcccacca aggcgacgat cagtagccgg 300
cctgagaggg tgaacggcca cattgggact gagacacggc ccagactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcgacgccgc gtgaaggaag 420
aagtatctcg gtatgtaaac ttctatcagc agggaagaaa atgacggtac ctgactaaga 480
agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggcaag cgttatccgg 540
atttactggg tgtaaaggga gcgtagacgg aagagcaagt ctgatgtgaa aggctggggc 600
ttaaccccag gactgcattg gaaactgttg ttctagagtg ccggagaggt aagcggaatt 660
cctagtgtag cggtgaaatg cgtagatatt aggaggaaca ccagtggcga aggcggctta 720
ctggacggta actgacgttg aggctcgaaa gcgtggggag caaacaggat tagataccct 780
ggtagtccac gccgtaaacg atgaatacta ggtgtcgggt ggcaaagcca ttcggtgccg 840
cagcaaacgc aataagtatt ccacctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 960
ccttaccaag tcttgacatc cctctgaccg tcccgtaacg gggacttccc ttcggggcag 1020
aggagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccttat ccttagtagc cagcacatga tggtgggcac tctagggaga 1140
ctgccgggga taacccggag gaaggcgggg acgacgtcaa atcatcatgc cccttatgat 1200
ttgggctaca cacgtgctac aatggcgtaa acaaagggaa gcgagacagc gatgttgagc 1260
gaatcccaaa aataacgtcc cagttcggac tgcagtctgc aactcgactg cacgaagctg 1320
gaatcgctag taatcgcgga tcagaatgcc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacctaa ccgaaaggaa 1440
ggagctgccg aaggcgggac cgataactgg ggtgaagtcg taacaaggta acc 1493
<210> 129
<211> 1386
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_producta
<220>
<221> misc_feature
<222> (1379)..(1379)
<223> n is a, c, g, or t
<400> 129
tcgagcgaag caattaagtg gatctcttcg gattgaaact tatttgactg agcggcggac 60
gggtgagtaa cgcgtgggta acctgcctca tacaggggga taacagttag aaatggctgc 120
taataccgca taagcgcaca ggaccgcatg gtctggtgtg aaaaactccg gtggtatgag 180
atggacccgc gtctgattag ctagttggag gggtaacggc ccaccaaggc gacgatcagt 240
agccggcctg agagggtgaa cggccacatt gggactgaga cacggcccag actcctacgg 300
gaggcagcag tggggaatat tgcacaatgg gggaaaccct gatgcagcga cgccgcgtga 360
aggaagaagt atctcggtat gtaaacttct atcagcaggg aagaaaatga cggtacctga 420
ctaagaagcc ccggctaact acgtgccagc agccgcggta atacgtaggg ggcaagcgtt 480
atccggattt actgggtgta aagggagcgt agacggaaga gcaagtctga tgtgaaaggc 540
tggggcttaa ccccaggact gcattggaaa ctgtttttct agagtgccgg agaggtaagc 600
ggaattccta gtgtagcggt gaaatgcgta gatattagga ggaacaccag tggcgaaggc 660
ggcttactgg acggtaactg acgttgaggc tcgaaagcgt ggggagcaaa caggattaga 720
taccctggta gtccacgccg taaacgatga atactaggtg tcgggtggca aagccattcg 780
gtgccgcagc aaacgcaata agtattccac ctggggagta cgttcgcaag aatgaaactc 840
aaaggaattg acggggaccc gcacaagcgg tggagcatgt ggtttaattc gaagcaacgc 900
gaagaacctt accaagtctt gacatccctc tgaccggccc gtaacggggc cttcccttcg 960
gggcagagga gacaggtggt gcatggctgt cgtcagctcg tgtcgtgaga tgttgggtta 1020
agtcccgcaa cgagcgcaac ccctatcctt agtagccagc aggttaagct gggcactcta 1080
gggagactgc cggggataac ccggaggaag gcggggacga cgtcaaatca tcatgcccct 1140
tatgatttgg gctacacacg tgctacaatg gcgtaaacaa agggaagcga gacagcgatg 1200
ttgagcaaat cccaaaaata acgtcccagt tcggactgca gtctgcaact cgactgcacg 1260
aagctggaat cgctagtaat cgcgaatcag aatgtcgcgg tgaatacgtt cccgggtctt 1320
gtacacaccg cccgtcacac catgggagtc agtaacgccc gaagtcagtg acccaaccnt 1380
tatagg 1386
<210> 130
<211> 1482
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_schinkii
<220>
<221> misc_feature
<222> (37)..(37)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (173)..(173)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (184)..(184)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (188)..(188)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (367)..(367)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1342)..(1342)
<223> n is a, c, g, or t
<400> 130
tgaacgctgg cggcgtgctt aacacatgca agtcgancgg agattgattt aacagagact 60
tcggttgaag ttgttctgat cttagtggcg gacgggtgag taacgcgtgg gtaacctgcc 120
ttgtactggg ggataacagc cagaaatgac tgctaatacc gcataagcgc acnggaccgc 180
atgntctngt gtgaaaaact ccggtggtac aagatggacc cgcgttggat tagctagttg 240
gcagggcaga ggcctaccaa ggcgacgatc catagccggc ctgagagggt gaacggccac 300
attgggactg agacacggcc cagactccta cgggaggcag cagtggggaa tattgcacaa 360
tgggggnaac cctgatgcag cgacgccgcg tgaaggaaga agtatctcgg tatgtaaact 420
tctatcagca gggaagaaaa tgacggtacc tgactaagaa gccccggcta actacgtgcc 480
agcagccgcg gtaatacgta gggggcaagc gttatccgga tttactgggt gtaaagggag 540
cgtagacggt atagcaagtc tgatgtgaaa ggcaggggct caacccctgg actgcattgg 600
aaactgttaa acttgagtgc cggagaggta agcggaattc ctagtgtagc ggtgaaatgc 660
gtagatatta ggaggaacac cagtggcgaa ggcggcttac tggacggtaa ctgacgttga 720
ggctcgaaag cgtggggagc aaacaggatt agataccctg gtagtccacg ccgtaaacga 780
tgaatactag gtgtcgggtg gcaaagccat tcggtgccgc agcaaacgca ataagtattc 840
cacctgggga gtacgttcgc aagaatgaaa ctcaaaggaa ttgacgggga cccgcacaag 900
cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaagt cttgacatcc 960
ccctgaccgg tccgtaacgg gacctttcct tcgggacagg ggagacaggt ggtgcatggt 1020
tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccctatc 1080
cttagtagcc agcggtttgg ccgggcactc tagggagact gccagggata acctggagga 1140
aggtggggat gacgtcaaat catcatgccc cttatgattt gggctacaca cgtgctacaa 1200
tggcgtaaac aaagggaagc gaccgggtga ccgtgagcaa atcccaaaaa taacgtccca 1260
gttcggactg tagtctgcaa cccgactaca cgaagctgga atcgctagta atcgcggatc 1320
agaatgccgc ggtgaatacg tncccgggtc ttgtacacac cgcccgtcac accatgggag 1380
tcagtaacgc ccgaagtcag tgacctaacc gaaagggagg agctgccgaa ggcgggaccg 1440
atgactgggg tgaagtcgta acaaggtagc cgtatcggaa gg 1482
<210> 131
<211> 1262
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_sp_M25
<400> 131
ataacagcca gaaatgactg ctaataccgc ataagcgcac agaaccgcat ggttcggtgt 60
gaaaaactcc ggtggtataa gatggacccg cgttggatta gctagttggc agggcagcgg 120
cctaccaagg cgacgatcca tagccggcct gagagggtga acggccacat tgggactgag 180
acacggccca gactcctacg ggaggcagca gtggggaata ttgcacaatg ggggaaaccc 240
tgatgcagcg acgccgcgtg aaggaagaag tatctcggta tgtaaacttc tatcagcagg 300
gaagataatg acggtacctg actaagaagc cccggctaac tacgtgccag cagccgcggt 360
aatacgtagg gggcaagcgt tatccggatt tactgggtgt aaagggagcg tagacggcgc 420
agcaagtctg atgtgaaagg caggggctta acccctggac tgcattggaa actgctgtgc 480
ttgagtgccg gaggggtaag cggaattcct agtgtagcgg tgaaatgcgt agatattagg 540
aggaacacca gtggcgaagg cggcttactg gacggtaact gacgttgagg ctcgaaagcg 600
tggggagcaa acaggattag ataccctggt agtccacgcc gtaaacgatg aatactaggt 660
gtcagggagc acagctcttt ggtgccgccg caaacgcatt aagtattcca cctggggagt 720
acgttcgcaa gaatgaaact caaaggaatt gacggggacc cgcacaagcg gtggagcatg 780
tggtttaatt cgaagcaacg cgaagaacct taccaaatct tgacatccct ctgaccggga 840
cttaaccgtc cctttccttc gggacagggg agacaggtgg tgcatggttg tcgtcagctc 900
gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccctatcct tagtagccag 960
cacgcartgg tgggcactct gaggagactg ccagggataa cctggaggaa ggcggggatg 1020
acgtcaaatc atcatgcccc ttatgatttg ggctacacac gtgctacaat ggcgtaaaca 1080
aagggaagcg aacccgcgag ggtgggcaaa tctcaaaaat aacgtcccag ttcggactgc 1140
agtctgcaac tcgactgcac gaagctggaa tcgctagtaa tcgcggatca gaatgccgcg 1200
gtgaatacgt tcccgggtct tgtacacacc gcccgtcaca ccatgggagt cagtaacgcc 1260
cg 1262
<210> 132
<211> 1372
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_stercoris
<400> 132
tgcaagtcga gcgaagcgct tacgacagaa ccttcggggg aagatgtaag ggactgagcg 60
gcggacgggt gagtaacgcg tgggtaacct gcctcataca gggggataac agttggaaac 120
ggctgctaat accgcataag cgcacggtat cgcatgatac agtgtgaaaa actccggtgg 180
tatgagatgg acccgcgtct gattagctag ttggaggggt aacggcccac caaggcgacg 240
atcagtagcc ggcctgagag ggtgaacggc cacattggga ctgagacacg gcccagactc 300
ctacgggagg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 360
gcgtgaagga agaagtatct cggtatgtaa acttctatca gcagggaaga aaatgacggt 420
acctgactaa gaagccccgg ctaactacgt gccagcagcc gcggtaatac gtagggggca 480
agcgttatcc ggatttactg ggtgtaaagg gagcgtagac ggaagagcaa gtctgatgtg 540
aaaggctggg gcttaacccc aggactgcat tggaaactgt ttttcttgag tgccggagag 600
gtaagcggaa ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc 660
gaaggcggct tactggacgg taactgacgt tgaggctcga aagcgtgggg agcaaacagg 720
attagatacc ctggtagtcc acgccgtaaa cgatgaatac taggtgttgg ggagcaaagc 780
tcttcggtgc cgcagcaaac gcaataagta ttccacctgg ggagtacgtt cgcaagaatg 840
aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag 900
caacgcgaag aaccttacca agtcttgaca tcgatctgac cggttcgtaa tggaaccttt 960
ccttcgggac agagaagaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt 1020
gggttaagtc ccgcaacgag cgcaacccct atcctcagta gccagcaggt gaagctgggc 1080
actctgtgga gactgccagg gataacctgg aggaaggcgg ggacgacgtc aaatcatcat 1140
gccccttatg atttgggcta cacacgtgct acaatggcgt aaacaaaggg aagcgagccc 1200
gcgaggggga gcaaatccca aaaataacgt cccagttcgg actgcagtct gcaactcgac 1260
tgcacgaagc tggaatcgct agtaatcgcg aatcagaatg tcgcggtgaa tacgttcccg 1320
ggtcttgtac acaccgcccg tcacaccatg ggagtcagta acgcccgaag tc 1372
<210> 133
<211> 1438
<212> DNA
<213> Artificial Sequence
<220>
<223> Blautia_wexlerae
<220>
<221> misc_feature
<222> (19)..(19)
<223> n is a, c, g, or t
<400> 133
caagtcgaac gggaattant ttattgaaac ttcggtcgat ttaatttaat tctagtggcg 60
gacgggtgag taacgcgtgg gtaacctgcc ttatacaggg ggataacagt cagaaatggc 120
tgctaatacc gcataagcgc acagagctgc atggctcagt gtgaaaaact ccggtggtat 180
aagatggacc cgcgttggat tagcttgttg gtggggtaac ggcccaccaa ggcgacgatc 240
catagccggc ctgagagggt gaacggccac attgggactg agacacggcc cagactccta 300
cgggaggcag cagtggggaa tattgcacaa tgggggaaac cctgatgcag cgacgccgcg 360
tgaaggaaga agtatctcgg tatgtaaact tctatcagca gggaagatag tgacggtacc 420
tgactaagaa gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc 480
gttatccgga tttactgggt gtaaagggag cgtagacggt gtggcaagtc tgatgtgaaa 540
ggcatgggct caacctgtgg actgcattgg aaactgtcat acttgagtgc cggaggggta 600
agcggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa 660
ggcggcttac tggacggtaa ctgacgttga ggctcgaaag cgtggggagc aaacaggatt 720
agataccctg gtagtccacg ccgtaaacga tgaataacta ggtgtcgggt ggcaaagcca 780
ttcggtgccg tcgcaaacgc agtaagtatt ccacctgggg agtacgttcg caagaatgaa 840
actcaaagga attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca 900
acgcgaagaa ccttaccaag tcttgacatc cgcctgaccg atccttaacc ggatctttcc 960
ttcgggacag gcgagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 1020
gttaagtccc gcaacgagcg caacccctat cctcagtagc cagcatttaa ggtgggcact 1080
ctggggagac tgccagggat aacctggagg aaggcgggga tgacgtcaaa tcatcatgcc 1140
ccttatgatt tgggctacac acgtgctaca atggcgtaaa caaagggaag cgagattgtg 1200
agatggagca aatcccaaaa ataacgtccc agttcggact gtagtctgca acccgactac 1260
acgaagctgg aatcgctagt aatcgcggat cagaatgccg cggtgaatac gttcccgggt 1320
cttgtacaca ccgcccgtca caccatggga gtcagtaacg cccgaagtca gtgacctaac 1380
tgcaaagaag gagctgccga aggcgggacc gatgactggg gtgaagtcgt aacaaggt 1438
<210> 134
<211> 1240
<212> DNA
<213> Artificial Sequence
<220>
<223> Butyrivibrio_fibrisolvens
<400> 134
gagtaacgcg tgggtaacct accttgtaca gggggacaac agttggaaac gactgctaat 60
accgcataag cgcacagcat cgcatgatgc agtgtgaaaa gttttttcgg tacaagatgg 120
acccgcgtct gattagctag ttggtgaggt aacggcccac caaggcgacg atcagtagcc 180
gacctgagag ggtgaccggc cacattggga ctgagacacg gcccaaactc ctacgggagg 240
cagcagtggg gaatattgca caatgggcga aagcctgatg cagcgacgcc gcgtgagcga 300
agaagtattt cggtatgtaa agctctatca gcagggaaga taatgacggt acctgactaa 360
gaagcaccgg ctaaatacgt gccagcagcc gcggtaatac gtatggtgca agcgttatcc 420
ggatttactg ggtgtaaagg gagcgtaggc ggttttacaa gtctgatgtg aaagcccggg 480
gctcaactcc ggtattgcat tggaaactgt agaactagag tgtcggaggg gtaagtggaa 540
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 600
tactggacga ttactgacgc tgaggctcga aagcgtgggg agcaaacagg attagatacc 660
ctggtagtcc acgccgtaaa cgatgaatac taggtgttgg cttccatagg gagtcggtgc 720
cgcagctaac gcaataagta ttccacctgg ggagtacgtt cgcaagaatg aaactcaaag 780
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 840
aaccttacca aatcttgaca tcctcttgac aaagtatgta atgtactctt ccttcgggac 900
aagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 960
ccgcaacgag cgcaaccctt atctttagta gccagcattt cggatgggca ctctagagag 1020
actgcccggg tgaaccggga ggaaggtggg gatgacgtca aatcatcatg ccccttatga 1080
tttgggctac acacgtgcta caatggcgta aacaaaggga agcaagtagg tgactatgag 1140
caaatctcaa aaataacgtc tcagttcgga ttgtagtctg caactcgact acatgaagct 1200
ggaatcgcta gtaatcgcga atcagaatgt cgcggtgaat 1240
<210> 135
<211> 1401
<212> DNA
<213> Artificial Sequence
<220>
<223> Butyrivibrio_fibrisolvens
<400> 135
acgatccctt cggggtgacg atttgttgac tgagtggcgg acgggtgagt aacgcgtggg 60
taacctacct tgtacagggg gacaacagtt ggaaacgact gctaataccg cataagcgca 120
cagcttcgca tgaagcagtg tgaaaagttt tttcggtaca agatggaccc gcgtctgatt 180
agctagttgg tgaggtaacg gcccaccaag gcgacgatca gtagccgacc tgagagggtg 240
accggccaca ttgggactga gacacggccc aaactcctac gggaggcagc agtggggaat 300
attgcacaat gggcgaaagc ctgatgcagc gacgccgcgt gagcgaagaa gtatttcggt 360
atgtaaagct ctatcagcag ggaagataat gacggtacct gactaagaag caccggctaa 420
atacgtgcca gcagccgcgg taatacgtat ggtgcaagcg ttatccggat ttactgggtg 480
taaagggagc gtaggcggtt ttacaagtct gatgtgaaag cccggggctc aactccggta 540
ttgcattgga aactgtagaa ctagagtgtc ggaggggtaa gtggaattcc tagtgtagcg 600
gtgaaatgcg tagatattag gaggaacacc agtggcgaag gcggcttact ggacgattac 660
tgacgctgag gctcgaaagc gtggggagca aacaggatta gataccctgg tagtccacgc 720
cgtaaacgat gaatactagg tgttggcttc catagggagt cggtgccgca gctaacgcaa 780
taagtattcc acctggggag tacgttcgca agaatgaaac tcaaaggaat tgacggggac 840
ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaaatc 900
ttgacatccc gatgacaaag catgtaatgt gctctctctt cggagcatcg gtgacaggtg 960
gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 1020
acccttgtcc ttagtagcca gcaattcggt tgggcactct agggagactg cccgggtgaa 1080
ccgggaggaa ggtggggatg acgtcaaatc atcatgcccc ttatgatttg ggctacacac 1140
gtgctacaat ggcgtaaaca aagggaagca aatatgtgag tatgagcaaa tctcaaaaat 1200
aacgtctcag ttcggattgt agtctgcaac tcgactacat gaagctggaa tcgctagtaa 1260
tcgcgaatca gaatgtcgcg gtgaatacgt tcccgggtct tgtacacacc gcccgtcaca 1320
ccatgggagt tgggaatgcc cgaagtctgt gacccaaccg taaggaggga gcagccgaag 1380
gcaggctcga taactggggt g 1401
<210> 136
<211> 1477
<212> DNA
<213> Artificial Sequence
<220>
<223> Butyrivibrio_fibrisolvens
<400> 136
tggcggcgtg cctaacacat gcaagtcgaa cggagttatt cgctgatgaa gcttcggcag 60
aatcttgaat aacttagtgg cggacgggtg agtaacgcgt gggtaacctg cctcatacag 120
ggggatagca gttggaaacg actgataaca ccgcataagc gcacagtgtc gcatgacaca 180
gtgtgaaaat atttataggt atgagatgga cccgcgtctg attagctagt tggtgaggta 240
acggcccacc aaggcgacga tcagtagccg gcctgagagg gcggacggcc acattgggac 300
tgagacacgg cccaaactcc tacgggaggc agcagtgggg gatattgcac aatgggcgaa 360
agcctgatgc agcgacgccg cgtgagtgaa gaagtatttc ggtatgtaaa gctctatcag 420
cagggaagaa agacctcgta agaggggatg acggtacctg agtaagaagc cccggctaac 480
tacgtgccag cagccgcggt aatacgtagg gggcaagcgt tatccggatt tactgggtgt 540
aaagggagcg tagacggtgt atcaagtctg aagtgaaacc ccacggctca accgtgggct 600
tgctttggaa actggtagac tagagtactg gagaggtaag cggaattcct ggtgtagtag 660
tgaaatgcgt agatatcagg aagaacatca gtggcgaagg cggcttactg gacagcaact 720
gacgttgagg ctcgaaagcg tggggagcaa acaggattag ataccctggt agtccacgcc 780
gtaaacgatg aatactaggt gttgggagac atagtctttc agtgccggcg ctaacgcaat 840
aagtattcca cctggggagt acgttcgcaa gaatgaaact caaaggaatt gacggggacc 900
cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct taccaaatct 960
tgagatccag atgaatgatg ggtaatgcca tcagtccttc gggacatctg agacaggtgg 1020
tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtc aagtcccgca acgagcgcaa 1080
cccttgtcca tagtagccag cagtaagatg ggcactctat ggagactgcc agggataacc 1140
tggaggaagg tggggatgac gtcaaatcat catgcccctt atgatttggg ccacacacgt 1200
gctacaatgt cgtaacaaag ggaagcaacc ctgcgaaggt gagcaaatcc caaaaataac 1260
gacccagttc ggactgtagg ctgcaacccg cctgcacgaa gctggaatcg ctagtaatcg 1320
cagatcagaa tgctgcggtg aatacgttcc cgggtcttgt acacaccgcc cgtcacacca 1380
tgggagtcgg aaatgcccaa agtcagtggc ctaaccgtaa ggagggagct tgctaaggca 1440
ggtcggataa ctggggtgaa gtcgtaacaa ggtagcc 1477
<210> 137
<211> 1292
<212> DNA
<213> Artificial Sequence
<220>
<223> Catonella_genomosp_P1_oral_clone
<400> 137
gatgaacgct ggcggcgtgc ctaacacatg caagtcgaac gagtggcgga cgggtgagta 60
acgcgtgggc aacctgccct atacaggggg atagcagctg gaaacggctg gtaagaccgc 120
ataaggaaat caggtatagg atggacccgc gtccgattag ccagttggca gggtaaaagc 180
ctaccaaagc gacgatcggt agccggactg agaggtcggg cggccacatt gggactgaga 240
cacggcccaa actcctacgg gaggcagcag tgggggatat tgcacaatgg aggaaactct 300
gatgcagcga cgccgcgtga gtgaagaagt atttcggtat gtaaagctct atcagcaggg 360
aagatgacgg tacctgacta agaagccccg gctaactacg tgccagcagc cgcggtaata 420
cgtagggggc aagcgttatc cggatttact gggtgtaaag ggagcgcagg cggttttgca 480
agttgagagt ggaagcaggg ggctcaaccc cctgactgct cccaaaactg taaaacttga 540
gtatgggaga ggcaggcgga attcctagtg tagcggtgaa atgcttagat attaggaaga 600
acaccggtgg cgaaggcggc ctgctggacc aactgacgct gaggctcgaa agcgtgggta 660
gcaaacagga ttagataccc tggtagtcca cgctgtaaac gatgaatact aggtgctggg 720
atttcggtgc cgtcgcaaac gcattaagta ttccacctgg ggagtacgtt cgcgagaatg 780
aagctcaagg gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgacg 840
caacgcgaag aaccttaccc ggtcttgaga tcgacaggtg gtgcatggtt gtcgtcagct 900
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccctattt ttagtagcca 960
gcggccgggc actctaaaga gactgccgag gataactcgg aggaaggcgg ggatgacgtc 1020
aaatcatcat gccccttatg accggggcta cacacgtgct acaatgtcag tcagagggaa 1080
gcgaaggcgt gagtcggagc aaatctcagg ctgcctcagt tcggatgtag tctgcaactc 1140
gactacagaa gctggaatcg ctagtaatcg caaatcagaa tgttgcggtg aatacgttcc 1200
cgggtcttgt acacaccgcc cgtcacacca tgggagtcgg aaatgcccga agtcagtgcc 1260
taaggagctg ccgaaggcag gtctggtgac tg 1292
<210> 138
<211> 1553
<212> DNA
<213> Artificial Sequence
<220>
<223> Catonella_morbi
<400> 138
atgagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 60
aacgaaccgc gactgagtgc ttgcacttgg tcaaggtgag tggcgaacgg gtgagtaaca 120
cgtgggtaac ctacctcata gtgggggata acagtcggaa acgactgcta ataccgcata 180
ggacatggga tcacatgatt ctgtgaggaa aggtggcgca agctatcgct aagagatgga 240
cccgcggtgc attagctagt tggtagggta agggcctacc aaggcgatga tgcatagccg 300
acctgagagg gtgatcggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtaggg aatcttccgc aatggacgca agtctgacgg agcaacgccg cgtgagtgaa 420
gaaggtcttc ggatcgtaaa gctctgttgt tagagaagaa cagcgcatag agtaactgct 480
atgcgtgtga cggtatctaa ccagaaagcc acggctaact acgtgccagc agccgcggta 540
atacgtaggt ggcgagcgtt gtccggattt attgggcgta aagggagtgt aggcggtctt 600
ttaagtctga tgtgaaagcc cacggctcaa ccgtggaggg tcattggaaa ctgggagact 660
tgagtgcaga agaggagagc ggaattccat gtgtagcggt gaaatgcgta gatatatgga 720
ggaacaccag tggcgaaggc ggctctctgg tctgtaactg acgctgaggc tcgaaagcgt 780
ggggagcaaa caggattaga taccctggta gtccacgccg taaacgatga gtgctaagtg 840
ttggaggggt tccacccttc agtgctggag ttaacgcaat aagcactccg cctggggagt 900
acggccgcaa ggctgaaact caaaggaatt gacggggacc cgcacaagcg gtggagcatg 960
tggtttaatt cgaagcaacg cgaagaacct taccaggtct tgacatcccg acgaccgctc 1020
tagagataga gtttttcttc ggaacgtcgg tgacaggtgg tgcatggttg tcgtcagctc 1080
gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccctataac tagttgccag 1140
cattgagatg gggactctag ttagactgcc ggtgacaaac cggaggaagg tggggatgac 1200
gtcaaatcat catgcccctt atgacctggg ctacacacgt gctacaatgg atggtacaac 1260
gagcagcgaa ctcgcgaggg taagcgaatc tctaaaagcc attctcagtt cggattgtag 1320
tctgcaactc gactacatga agccggaatc gctagtaatc gcggatcagc acgccgcggt 1380
gaatacgttc ccgggtcttg tacacaccgc ccgtcacacc acgagagttt gtaacacccg 1440
aagccggtgg cctaaccttt taggagggag ccgtcgaagg tgggatagat gattggggtg 1500
aagtcgtaac aaggtagccg tatcggaagg tgcggctgga tcacctcctt tct 1553
<210> 139
<211> 1215
<212> DNA
<213> Artificial Sequence
<220>
<223> Catonella_morbi
<400> 139
gatgaacgct ggcggcgtgc ctaacacatg caagtcgaac ggagattacg gacggaagtt 60
ttcggatgga agactgtaat tcttagtggc ggacgggtga gtaacgcgtg ggcaacctgc 120
cctatacagg gggatagcag ctggaaacgg ctggtaagac cgcataagtc ggcggaaccg 180
catggttttg tcgggaaatg agcaatcagg tataggatgg acccgcgtcc gattagccag 240
ttggcagggt aaaagcctac caaagcgacg atcggtagcc ggactgagag gtcgggcggc 300
cacattggga ctgagacacg gcccaaactc ctacgggagg cagcagtggg ggatattgca 360
caatggagga aactctgatg cagcgacgcc gcgtgagtga agaagtatgt cggtatgtga 420
aagctctatc agcagggaag atgatgacgg tacctgacta agaagccccg gctaactacg 480
tgccagcagc cgcggtaata cgtagggggc aagcgttatc cggatttact gggtgtaaag 540
ggagcgcagg cggttttgca agttgagagt ggaagcaggg ggctcaaccc cctgactgct 600
cccaaaactg taaaacttga gtatgggaga ggcaggcgga attcctagtg tagcggtgaa 660
atgcttagat attaggaaga acaccggtgg cgaaggcggc ctgctggacc aaaactgacg 720
ctgaggctcg aaagcgtggg tagcaaacag gattagatac cctggtagtc cacgctgtaa 780
acgatgaata ctaggtgctg ggaggcataa gcctttcggt gccgtcgcaa acgcattaag 840
tattccacct ggggagtacg ttcgcgagaa tgaagctcaa gggaattgac ggggacccgc 900
acaagcggtg gagcatgtgg tataattcga cgcaacgcga aagaacctta cccgggtctt 960
gagaatcctc ctgaaatact gagttaatgt cagtagtcct tcgggacagg agagacaggt 1020
ggtgcatggg tgtcgtcagc tcgtgtcgtg agatgttggg gttaagtccg cgacgagcgc 1080
agcccctatt cttagtagcc agcgggtagg gccgggcacc ctaaagaaac tgcccgagga 1140
ttactcggga gggaaggcgg cggatgacgt cgaatcatca tgcctcttat gaccggggct 1200
gccacgtctc aggta 1215
<210> 140
<211> 1366
<212> DNA
<213> Artificial Sequence
<220>
<223> Catonella_sp_oral_clone_FL037
<400> 140
gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc aagtcgaacg 60
agtggcggac gggtgagtaa cgcgtgggta acctgccccg tacaggggga tagcgtcggg 120
aaactgacgg taagaccgca tagggaaaac tggtatggga tggacccgcg tccgattagc 180
cagttggcag ggtaaaggcc taccaaagct tcgatcggta gccggactga gaggtcggac 240
ggccacattg ggactgagac acggcccaga ctcctacggg aggcagcagt gggggatatt 300
gcacaatgga ggaaactctg atgcagcgac gccgcgtgag tgaagaagtg ctccggcatg 360
taaagctctt tcagcaggga agatgacggt acctgaataa gaagccccgg ctaactacgt 420
gccagcagcc gcggtaatac gtagggggca agcgttatcc ggatttactg ggtgtaaagg 480
gagcgcaggc ggtctggcaa gttgagagtg gaagcagggg gctcaacccc ctgactgctc 540
ccaaaactgt tggactggag tatgggagag gcaggcggaa ttcctagtgt agcggtgaaa 600
tgctcagata ttaggaagaa caccggtggc gaaggcggcc tgctggacca actgacgctg 660
aggctcgaga gcgtggggag cgaacaggat tagataccct ggtagtccac gccgtaaacg 720
atgaatacta ggtgccggga tttcggtgcc gtcgcaaacg cattgagtat tccacctggg 780
gagtacgttc gcaagaatga aactcaaagg aattgacggg gacccgcgca agcggtggag 840
catgtggttt aattcgaagc aacgcgaaga accttacccg gtcttgagat cgacaggtgg 900
tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 960
cccctgttct tagtagccag cggccgggca ctctaaggag actgccgggg ataacccgga 1020
ggaaggcggg gatgacgtca aatcatcatg ccccttatga cttgggcgac acacgtgcta 1080
caatggcgta caaagggaag cgagctcgtg agagtaagcg aaactcaaaa cgtctcagtt 1140
cggatgtagt ctgcaacccg actacagaag ctggaatcgc tagtaatcgc agatcagcat 1200
gctgcggtga atacgttccc gggtcttgta cacaccgccc gtcacaccat gggagtcggt 1260
aatgcccgaa gccagtaacc agggagctgt cgaaggcagg actgataact ggggtgaagt 1320
cgtaacaagg tagccgtatc ggaaggtgcg gctggaacac ctcctt 1366
<210> 141
<211> 1266
<212> DNA
<213> Artificial Sequence
<220>
<223> Citrobacter_youngae
<400> 141
ttaaattgaa gagtttgatc atggctcaga ttgaacgctg gcggcaggcc taacacatgc 60
aagtcgaacg gtagcacaga gagcttgctc tcgggtgacg agtggcggac gggtgagtaa 120
tgtctgggaa actgcccgat ggagggggat aactactgga aacggtagct aataccgcat 180
aacgtcgcaa gaccaaagag ggggaccttc gggcctcttg ccatcggatg tgcccagatg 240
ggattagctt gttggtgggg taacggctca ccaaggcgac gatccctagc tggtctgaga 300
ggatgaccag ccacactgga actgagacac ggtccagact cctacgggag gcagcagtgg 360
ggaatattgc acaatgggcg caagcctgat gcagccatgc cgcgtgtatg aagaaggcct 420
tcgggttgta aagtactttc agcgaggagg aaggcgttgt ggttaataac cgcagcgatt 480
gacgttactc gcagaagaag caccggctaa ctccgtgcca gcagccgcgg taatacggag 540
ggtgcaagcg ttaatcggaa ttactgggcg taaagcgcac gcaggcggtc tgttaagtca 600
gatgtgaaat ccccgggctc aacctgggaa ctgcatttga aactggcagg cttgagtctc 660
gtagaggggg gtagaattcc aggtgtagcg gtgaaatgcg tagagatctg gaggaatacc 720
ggtggcgaag gcggccccct ggacgaagac tgacgctcag gtgcgaaagc gtggggagca 780
aacaggatta gataccctgg tagtccacgc cgtaaacgat gtctatttgg aggttgtgcc 840
cttgaggcgt ggcttccgga gctaacgcgt taaatagacc gcctggggag tacggccgca 900
aggttaaaac tcaaatgaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat 960
tcgatgcaac gcgaagaacc ttacctggtc ttgacatcca cagaagtttt cagagatgag 1020
aacgtgcctt cgggaactgt gagacaggtg ctgcatggct gtcgtcagct cgtgttgtga 1080
aatgttgggt taagtcccgc aacgagcgca acccttatcc tttgttgcca gcggttaggc 1140
cgggaactca aaggagactg ccagtgataa actggaggaa ggtggggatg acgtcaagtc 1200
atcatggccc ttacgaccag ggctacacac gtgctacaat ggcatataca aagagaagcg 1260
acctcg 1266
<210> 142
<211> 1435
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridiales_sp_SM4_1
<400> 142
gacgaattga ctgagtggcg gacgggtgag taacgcgtgg gtaacctgcc tcacactggg 60
ggacaacagc tggaaacggc tgctaatacc gcataagcgc acagcttcgc atgaagcagt 120
gtgaaaaact ccggtggtgt gagatggacc cgcgtctgat tagctagttg gtaaggtaac 180
ggcttaccaa ggcgacgatc agtagccgac ctgagagggt gaccggccac attgggactg 240
agacacggcc caaactccta cgggaggcag cagtggggaa tattgcacaa tgggggaaac 300
cctgatgcag cgacgccgcg tgagtgaaga agtatttcgg tatgtaaagc tctatcagca 360
gggaagaaaa tgacggtacc tgactaagaa gccccggcta actacgtgcc agcagccgcg 420
gtaatacgta gggggcaagc gttatccgga tttactgggt gtaaagggag cgtagacggc 480
gaagcaagtc tgaagtgaaa gcccggggct caaccgcggg actgctttgg aaactgtttt 540
gctagagtgc tggagaggta agtggaattc ctagtgtagc ggtgaaatgc gtagatatta 600
ggaggaacac cagtggcgaa ggcggcttac tggacagtaa ctgacgttga ggctcgaaag 660
cgtggggagc aaacaggatt agataccctg gtagtccacg ccgtaaacga tgaatactag 720
gtgttggtga gcaaagctca tcggtgccgt cgcaaacgca ataagtattc cacctgggga 780
gtacgttcgc aagaatgaaa ctcaaaggaa ttgacgggga cccgcacaag cggtggagca 840
tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaagt cttgacatcg gaatgaccgg 900
aacttaaccg ttccttttct tcggaacatt ccagacaggt ggtgcatggt tgtcgtcagc 960
tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttatc ctaagtagcc 1020
agcagttcgg ctgggcactc ttgggagact gccagggata acctggagga aggtggggat 1080
gacgtcaaat catcatgccc cttatgattt gggctacaca cgtgctacaa tggcgtaaac 1140
aaagggaagc gaagctgtga agctgagcaa atctcaaaaa taacgtctca gttcggattg 1200
tagtctgcaa ctcgactaca tgaagctgga atcgctagta atcgcggatc agaatgccgc 1260
ggtgaatacg ttcccgggtc ttgtacacac cgcccgtcac accatgggag tcagtaacgc 1320
ccgaagtcag tgacccaacc gcaaggaggg agctgccgaa ggcgggaccg ataactgggg 1380
tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc tttct 1435
<210> 143
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_asparagiforme
<400> 143
tgagagtttg atcctggctc aggatgaacg ctggcggcgt gcctaacaca tgcaagtcga 60
acgaagcatt ttagatgaag ttttcggatg gattctgaga tgactgagtg gcggacgggt 120
gagtaacacg tggataacct gcctcacact gggggacaac agttagaaat gactgctaat 180
accgcataag cgcacagtac cgcatggtac ggtgtgaaaa actccggtgg tgtgagatgg 240
atccgcgtct gattagccag ttggcggggt aacggcccac caaagcgacg atcagtagcc 300
gacctgagag ggtgaccggc cacattggga ctgagacacg gcccaaactc ctacgggagg 360
cagcagtggg gaatattgca caatgggcga aagcctgatg cagcgacgcc gcgtgagtga 420
agaagtattt cggtatgtaa agctctatca gcagggaaga taatgacggt acctgactaa 480
gaagccccgg ctaactacgt gccagcagcc gcggtaatac gtagggggca agcgttatcc 540
ggatttactg ggtgtaaagg gagcgtagac ggcatggcaa gtctgaagtg aaaacccagg 600
gctcaaccct gggactgctt tggaaactgt caagctagag tgcaggagag gtaagtggaa 660
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 720
tactggactg taactgacgt tgaggctcga aagcgtgggg agcaaacagg attagatacc 780
ctggtagtcc acgccgtaaa cgatgagtgc taggtgttgg ggggcaaagc ccttcggtgc 840
cgtcgcaaac gcaataagca ctccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tccccctgac cggcgtgtaa cggcgccttt ccttcgggac 1020
aggggagaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctt atccttagta gccagcatta agatgggcac tctagggaga 1140
ctgccaggga caacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgat 1200
ttgggctaca cacgtgctac aatggcgtaa acaaagggaa gcgaccctgc gaaggtgagc 1260
aaatctcaaa aataacgtcc cagttcggac tgtagtctgc aacccgacta cacgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagcaac gcccgaagtc agtgacccaa ccgaaaggag 1440
ggagctgccg aaggcggggc aggtaactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 144
<211> 1491
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_bartlettii
<400> 144
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc 60
gatcttcttc ggaagagagc ggcggacggg tgagtaacgc gtgggtaacc tgccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa cataagaaat tcgcatgttt 180
ttcttatcaa agctccggcg gtacaggatg gacccgcgtc tgattagcta gttggtgagg 240
taacggctca ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagcg atgaaggcct tcgggtcgta aagctctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttta agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
aggacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagtagc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtac 780
tagctgtcgg aggttacccc cttcggtggc gcagctaacg cattaagtac tccgcctggg 840
gagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat ccttttgacc 960
gatgcctaat cgcatctttc ccttcgggga cagaagtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgcctttagt 1080
tgccatcatt aagttgggca ctctagaggg actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtgg 1200
tacagagggc agcgaagtcg tgaggccaag ctaatccctt aaagccattc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccatgg gagttggggg 1380
cgcccgaagc cggctagcta accttttgga agcggtcgtc gaaggtgaaa ccaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc t 1491
<210> 145
<211> 1476
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_bifermentans
<220>
<221> misc_feature
<222> (1449)..(1449)
<223> n is a, c, g, or t
<400> 145
catrgctcag gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc gatctcttcg 60
gagagagcgg cggacgggtg agtaacgcgt gggtaacctg ccctgtacac acggataaca 120
taccgaaagg tatactaata cgggataaca tatgaaagtc gcatggcttt tgtatcaaag 180
ctccggcggt acaggatgga cccgcgtctg attagctagt tggtaaggta atggcttacc 240
aaggcaacga tcagtagccg acctgagagg gtgatcggcc acactggaac tgagacacgg 300
tccagactcc tacgggaggc agcagtgggg aatattgcac aatgggcgaa agcctgatgc 360
agcaacgccg cgtgagcgat gaaggccttc gggtcgtaaa gctctgtcct caaggaagat 420
aatgacggta cttgaggagg aagccccggc taactacgtg ccagcagccg cggtaatatg 480
tagggggcta gcgttatccg gaattactgg gcgtaaaggg tgcgtaggtg gttttttaag 540
tcagaagtga aaggctacgg ctcaaccgta gtaagctttt gaaactagag aacttgagtg 600
caggagagga gagtagaatt cctagtgtag cggtgaaatg cgtagatatt aggaggaata 660
ccagtagcga aggcggctct ctggactgta actgacactg aggcacgaaa gcgtggggag 720
caaacaggat tagataccct ggtagtccac gccgtaaacg atgagtacta ggtgtcgggg 780
gttacccccc tcggtgccgc actaacgcat taagtactcc gcctgggaag tacgctcgca 840
agagtgaaac tcaaaggaat ttdcggggac ccgcacaagt agcggagcat gtggtttaat 900
tcgaagcaac gcgaagaacc ttacctaagc ttgacatccc actgacctct ccctaatcgg 960
agatttccct tcggggacag tggtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 1020
gagatgttgg gttaagtccc gcaacgagcg caacccttgc ctttagttgc cagcattaag 1080
ttgggcactc tagagggact gccgaggata actcggagga aggtggggat gacgtcaaat 1140
catcatgccc cttatgctta gggctacaca cgtgctacaa tgggtggtac agagggttgc 1200
caagccgcga ggtggagcta atcccttaaa gccattctca gttcggattg taggctgaaa 1260
ctcgcctaca tgaagctgga gttactagta atcgcagatc agaatgctgc ggtgaatgcg 1320
ttcccgggtc ttgtacacac cgcccgtcac accatggaag ttgggggcgc ccgaagccgg 1380
ttagctaacc ttttaggaag cggccgtcga aggtgaacaa atgactgggg tgaagtcgta 1440
acaaggtanc cgtatcggaa ggtgcggcbg gatcaa 1476
<210> 146
<211> 1498
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_bifermentans
<220>
<221> misc_feature
<222> (1)..(6)
<223> n is a, c, g, or t
<400> 146
nnnnnngaga gtttgatcct ggctcaggat gaacgctggc ggcgtgccta acacatgcaa 60
gtcgagcgat ctcttcggag agagcggcgg acgggtgagt aacgcgtggg taacctgccc 120
tgtacacacg gataactaac cgaaaggtat actaatacgg gataacatat gaaagtcgca 180
tggcttttga tatcaaagct ccggcggtac aggatggacc cgcgtgatta gctagttggt 240
aaggtaatgg cttaccaagg caacgatcag tagccgacct gagagggtga tcggccacac 300
tggaactgag acacggtcca gactcctacg ggaggcagca gtggggaata ttgcacaatg 360
ggcgaaagcc tgatgcagca acgccgcgtg agcgatgaag gccttcgggt cgtaaagctc 420
tgtcctcaag gaagataatg acggtacttg aggaggaagc cccggctaac tacgtgccag 480
cagccgcggt aatacgtagg gggctagcgt tatccggaat tactgggcgt aaagggtgcg 540
taggtggttt tttaagtcag aagtgaaagg ctacggctca accgtagtaa gcttttcaaa 600
ctagagaact tgagtgcagg agaggagagt agaattccta gtgtagcggt gaaatgcgta 660
gatattagga ggaataccag tagcgaaggc ggctctctgg actgtaactg acactgaggc 720
acgaaagcgt ggggagcaaa caggattaga taccctggta gtccacgccg taaacgatga 780
gtactaggtg tcggggttac ccccctcggt gccgcagcta acgcattaag tactccgcct 840
gggaagtacg atcgcaagat taaaactcaa aggaattgac ggggacccgc acaagtagcg 900
gagcatgtgg tttaattcga agcaacgcga agaaccttac ctaagcttga catcccactg 960
acctctccct aatcggagat ttccttcggg gacagtggtg acaggtggtg catggttgtc 1020
gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac gagcgcaacc cttgccttta 1080
gttgccagca ttaagttggg cactctagag ggactgccga ggataactcg gaggaaggtg 1140
gggatgacgt caaatcatca tgccccttat gcttagggct acacacgtgc tacaatgggt 1200
ggtacagagg gttgccaagc cgcgaggtgg agctaatccc ttaaagccat tctcagttcg 1260
gattgtaggc tgaaactcgc ctacatgaag ctggagttac tagtaatcgc agatcagaat 1320
gctgcggtga atgcgttccc gggtcttgta cacaccgccc gtcacaccat ggaagttggg 1380
ggcgcccgaa gccggttagc taacctttta ggaagcggcc gtcgaaggtg aaaccaatga 1440
ctggggtgaa gtcgtaacaa ggtagccgta tcggaaggtg cggctggatc acctcctt 1498
<210> 147
<211> 1463
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_bifermentans
<400> 147
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc 60
gatctcttcg gagagagcgg cggacgggtg agtaacgcgt gggtaacctg ccctgtacac 120
acggataaca taccgaaagg tatactaata cgggataaca tatgaaagtc gcatggcttt 180
tgtatcaaag ctccggcggt acaggatgga cccgcgtctg attagctagt tggtaaggta 240
atggcttacc aaggcaacga tcagtagccg acctgagagg gtgatcggcc acactggaac 300
tgagacacgg tccagactcc tacgggaggc agcagtgggg aatattgcac aatgggcgaa 360
agcctgatgc agcaacgccg cgtgagcgat gaaggccttc gggtcgtaaa gctctgtcct 420
caaggaagat aatgacggta cttgaggagg aagccccggc taactacgtg ccagcagccg 480
cggtaatacg tagggggcta gcgttatccg gaattactgg gcgtaaaggg tgcgtaggtg 540
gttttttaag tcagaagtga aaggctacgg ctcaaccgta gtaagctttt gaaactagag 600
aacttgagtg caggagagga gagtagaatt cctagtgtag cggtgaaatg cgtagatatt 660
aggaggaata ccagtagcga aggcggctct ctggactgta actgacactg aggcacgaaa 720
gcgtggggag caaacaggat tagataccct ggtagtccac gccgtaaacg atgagtacta 780
ggtgtcgggg gttacccccc tcggtgccgc agctaacgca ttaagtactc cgcctgggaa 840
gtacgctcgc aagagtgaaa ctcaaaggaa ttgacgggga cccgcacaag tagcggagca 900
tgtggtttaa ttcgaagcaa cgcgaagaac cttacctaag cttgacatcc cactgacctc 960
tccctaatcg gagatttccc ttcggggaca gtggtgacag gtggtgcatg gttgtcgtca 1020
gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaacccttg cctttagttg 1080
ccagcattaa gttgggcact ctagagggac tgccgaggat aactcggagg aaggtgggga 1140
tgacgtcaaa tcatcatgcc ccttatgctt agggctacac acgtgctaca atgggtggta 1200
cagagggttg ccaagccgcg aggtggagct aatcccttaa agccattctc agttcggatt 1260
gtaggctgaa actcgcctac atgaagctgg agttactagt aatcgcagat cagaatgctg 1320
cggtgaatgc gttcccgggt cttgtacaca ccgcccgtca caccatggaa gttgggggcg 1380
cccgaagccg gttagctaac cttttaggaa gcggccgtcg aaggtgaaac caatgactgg 1440
ggtgaagtcg taacaaggta acc 1463
<210> 148
<211> 1463
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_bifermentans
<400> 148
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc 60
gatctcttcg gagagagcgg cggacgggtg agtaacgcgt gggtaacctg ccctgtacac 120
acggataaca taccgaaagg tatactaata cgggataaca tacgaaagtc gcatggcttt 180
tgtatcaaag ctccggcggt acaggatgga cccgcgtctg attagctagt tggtaaggta 240
atggcttacc aaggcaacga tcagtagccg acctgagagg gtgatcggcc acactggaac 300
tgagacacgg tccagactcc tacgggaggc agcagtgggg aatattgcac aatgggcgaa 360
agcctgatgc agcaacgccg cgtgagcgat gaaggccttc gggtcgtaaa gctctgtcct 420
caaggaagat aatgacggta cttgaggagg aagccccggc taactacgtg ccagcagccg 480
cggtaatacg tagggggcta gcgttatccg gaattactgg gcgtaaaggg tgcgtaggtg 540
gttttttaag tcagaagtga aaggctacgg ctcaaccgta gtaagctttt gaaactagag 600
aacttgagtg caggagagga gagtagaatt cctagtgtag cggtgaaatg cgtagatatt 660
aggaggaata ccagtagcga aggcggctct ctggactgta actgacactg aggcacgaaa 720
gcgtggggag caaacaggat tagataccct ggtagtccac gccgtaaacg atgagtacta 780
ggtgtcgggg gttacccccc tcggtgccgc agctaacgca ttaagtactc cgcctgggaa 840
gtacgctcgc aagagtgaaa ctcaaaggaa ttgacgggga cccgcacaag tagcggagca 900
tgtggtttaa ttcgaagcaa cgcgaagaac cttacctaag cttgacatcc cactgacctc 960
tccctaatcg gagatttccc ttcggggaca gtggtgacag gtggtgcatg gttgtcgtca 1020
gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaacccttg cctttagttg 1080
ccagcattaa gttgggcact ctagagggac tgccgaggat aactcggagg aaggtgggga 1140
tgacgtcaaa tcatcatgcc ccttatgctt agggctacac acgtgctaca atgggtggta 1200
cagagggttg ccaagccgcg aggtggagct aatcccttaa agccattctc agttcggatt 1260
gtaggctgaa actcgcctac atgaagctgg agttactagt aatcgcagat cagaatgctg 1320
cggtgaatgc gttcccgggt cttgtacaca ccgcccgtca caccatggaa gttgggggcg 1380
cccgaagccg gttagctaac cttttaggaa gcggccgtcg aaggtgaaac caatgactgg 1440
ggtgaagtcg taacaaggta acc 1463
<210> 149
<211> 1536
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_bolteae
<400> 149
ttaaacatga gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc 60
aagtcgaacg aagcaattga aggaagtttt cggatggaat tcgattgact gagtggcgga 120
cgggtgagta acgcgtggat aacctgcctc acactggggg ataacagtta gaaatgactg 180
ctaataccgc ataagcgcac agtaccgcat ggtacagtgt gaaaaactcc ggtggtgtga 240
gatggatccg cgtctgatta gccagttggc ggggtaacgg cccaccaaag cgacgatcag 300
tagccgacct gagagggtga ccggccacat tgggactgag acacggccca aactcctacg 360
ggaggcagca gtggggaata ttgcacaatg ggcgaaagcc tgatgcagcg acgccgcgtg 420
agtgaagaag tatttcggta tgtaaagctc tatcagcagg gaagaaaatg acggtacctg 480
actaagaagc cccggctaac tacgtgccag cagccgcggt aatacgtagg gggcaagcgt 540
tatccggatt tactgggtgt aaagggagcg tagacggcga agcaagtctg aagtgaaaac 600
ccagggctca accctgggac tgctttggaa actgttttgc tagagtgtcg gagaggtaag 660
tggaattcct agtgtagcgg tgaaatgcgt agatattagg aggaacacca gtggcgaagg 720
cggcttactg gacgataact gacgttgagg ctcgaaagcg tggggagcaa acaggattag 780
ataccctggt agtccacgcc gtaaacgatg aatgctaggt gttggggggc aaagcccttc 840
ggtgccgtcg caaacgcagt aagcattcca cctggggagt acgttcgcaa gaatgaaact 900
caaaggaatt gacggggacc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg 960
cgaagaacct taccaagtct tgacatcctc ttgaccggcg tgtaacggcg ccttcccttc 1020
ggggcaagag agacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt 1080
aagtcccgca acgagcgcaa cccttatcct tagtagccag caggtaaagc tgggcactct 1140
agggagactg ccagggataa cctggaggaa ggtggggatg acgtcaaatc atcatgcccc 1200
ttatgatttg ggctacacac gtgctacaat ggcgtaaaca aagggaagca agacagtgat 1260
gtggagcaaa tcccaaaaat aacgtcccag ttcggactgt agtctgcaac ccgactacac 1320
gaagctggaa tcgctagtaa tcgcgaatca gaatgtcgcg gtgaatacgt tcccgggtct 1380
tgtacacacc gcccgtcaca ccatgggagt cagcaacgcc cgaagtcagt gacccaactc 1440
gcaagagagg gagctgccga aggcggggca ggtaactggg gtgaagtcgt aacaaggtag 1500
ccgtatcgga aggtgcggct ggatcacctc ctttct 1536
<210> 150
<211> 1517
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_butyricum
<400> 150
tttttattga gagtttgatc ctggctcagg acgaacgctg gcggcgtgct taacacatgc 60
aagtcgagcg atgaagcttc ttcggaagtg gattagcggc ggacgggtga gtaacacgtg 120
ggtaacctgc ctcatagagg ggaatagcct ttcgaaagga agattaatac cgcataagat 180
tgtagtaccg catggtacag caattaaagg agtaatccgc tatgagatgg acccgcgtcg 240
cattagctag ttggtgaggt aacggctcac caaggcgacg atgcgtagcc gacctgagag 300
ggtgatcggc cacattggga ctgagacacg gcccagactc ctacgggagg cagcagtggg 360
gaatattgca caatggggga aaccctgatg cagcaacgcc gcgtgagtga tgacggtctt 420
cggattgtaa agctctgtct ttagggacga taatgacggt acctaaggag gaagccacgg 480
ctaactacgt gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttactg 540
ggcgtaaagg gagcgtaggt ggatatttaa gtgggatgtg aaatactcgg gcttaacctg 600
ggtgctgcat tccaaactgg atatctagag tgcaggagag gaaaggagaa ttcctagtgt 660
agcggtgaaa tgcgtagaga ttaggaagaa taccagtggc gaaggcgcct ttctggactg 720
taactgacac tgaggctcga aagcgtgggg agcaaacagg attagatacc ctggtagtcc 780
acgccgtaaa cgatgaatac taggtgtagg ggttgtcatg acctctgtgc cgccgctaac 840
gcattaagta ttccgcctgg ggagtacggt cgcaagatta aaactcaaag gaattgacgg 900
gggcccgcac aagcagcgga gcatgtggtt taattcgaag caacgcgaag aaccttacct 960
agacttgaca tctcctgaat tactctgtaa tggaggaagc cacttcggtg gcaggaagac 1020
aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga 1080
gcgcaaccct tattgttagt tgctaccatt tagttgagca ctctagcgag actgcccggg 1140
ttaaccggga ggaaggtggg gatgacgtca aatcatcatg ccccttatgt ctagggctac 1200
acacgtgcta caatggtcgg tacaatgaga tgcaacctcg cgagagtgag caaaactata 1260
aaaccgatct cagttcggat tgtaggctga aactcgccta catgaagctg gagttgctag 1320
taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg ccttgtacac accgcccgtc 1380
acaccatgag agttggcaat acccaaagtt cgtgagctaa ccgcaaggag gcagcgacct 1440
aaggtagggt cagcgattgg ggtgaagtcg taacaaggta gccgtaggag aacctgcggc 1500
tggatcacct cctttct 1517
<210> 151
<211> 1434
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_butyricum
<400> 151
tgcttaacac atgcaagtcg agcgatgaag ctccttcggg agtggattag cggcggacgg 60
gtgagtaaca cgtgggtaac ctgcctcata gaggggaata gcctttcgaa aggaagatta 120
ataccgcata agattgtttt accgcatggt acagcaatta aaggagtaat ccgctatgag 180
atggacccgc gtcgcattag ctagttggtg aggtaacggc tcaccaaggc gacgatgcgt 240
agccgacctg agagggtgat cggccacatt gggactgaga cacggcccag actcctacgg 300
gaggcagcag tggggaatat tgcacaatgg gggaaaccct gatgcagcaa cgccgcgtga 360
gtgatgacgg ccttcgggtt gtaaaactct gtctttgggg acgataatga cggtacccaa 420
ggaggaagcc acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt 480
gtccggattt actgggcgta aagggagcgt aggtggatat ttaagtggga tgtgaaatac 540
tcgggcttaa cctgggtgct gcattccaaa ctggatatct agagtgcagg agaggaaagg 600
agaattccta gtgtagcggt gaaatgcgta gagattagga agaataccag tggcgaaggc 660
gcctttctgg actgtaactg acactgaggc tcgaaagcgt ggggagcaaa caggattaga 720
taccctggta gtccacgccg taaacgatga atactaggtg taggggttgt catgacctct 780
gtgccgccgc taacgcatta agtattccgc ctggggagta cggtcgcaag attaaaactc 840
aaaggaattg acgggggccc gcacaagcag cggagcatgt ggtttaattc gaagcaacgc 900
gaagaacctt acctagactt gacatctcct gaattactct gtaatggagg aagccacttc 960
ggtggcagga agacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt 1020
aagtcccgca acgagcgcaa cccttattgt tagttgctac catttagttg agcactctag 1080
cgagactgcc cgggttaacc gggaggaagg tggggatgac gtcaaatcat catgcccctt 1140
atgtctaggg ctacacacgt gctacaatgg tcggtacaat gagatgcaac ctcgcgagag 1200
tgagcaaaac tataaaaccg atctcagttc ggattgtagg ctgaaactcg cctacatgaa 1260
gctggagttg ctagtaatcg cgaatcagaa tgtcgcggtg aatacgttcc cgggccttgt 1320
acacaccgcc cgtcacacca tgagagttgg caatacccaa agttcgtgag ctaaccgcaa 1380
ggaggcagcg acctaaggta gggtcagcga ttggggtgaa gtcgtaacaa ggta 1434
<210> 152
<211> 1521
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_coccoides
<400> 152
tttgagtttg atcctggctc aggatgaacg ctggcggcgt gcttaacaca tgcaagtcga 60
gcgaagcgct aagacagatt tcttcggatt gaagtctttg tgactgagcg gcggacgggt 120
gagtaacgcg tgggtaacct gcctcataca gggggataac agttagaaat gactgctaat 180
accgcataag cgcacaggac cgcatggtct ggtgtgaaaa actccggtgg tatgagatgg 240
acccgcgtct gattagctag ttggaggggt aacggcccac caaggcgacg atcagtagcc 300
ggcctgagag ggtgaacggc cacattggga ctgagacacg gcccagactc ctacgggagg 360
cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc gcgtgaagga 420
agaagtatct cggtatgtaa acttctatca gcagggaaga aaatgacggt acctgactaa 480
gaagccccgg ctaactacgt gccagcagcc gcggtaatac gtagggggca agcgttatcc 540
ggatttactg ggtgtaaagg gagcgtagac ggaagagcaa gtctgatgtg aaaggctggg 600
gcttaacccc aggactgcat tggaaactgt tgttctagag tgccggagag gtaagcggaa 660
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 720
tactggacgg taactgacgt tgaggctcga aagcgtgggg agcaaacagg attagatacc 780
ctggtagtcc acgccgtaaa cgatgaatac taggtgtcgg gtggcaaagc cattcggtgc 840
cgcagcaaac gcaataagta ttccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tccctctgac cgtcccgtaa cgggggcttc ccttcggggc 1020
agaggagaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctt atccttagta gccagcacat gatggtgggc actctaggga 1140
gactgccggg gataacccgg aggaaggcgg ggacgacgtc aaatcatcat gccccttatg 1200
atttgggcta cacacgtgct acaatggcgt aaacaaaggg aagcgagaca gcgatgttga 1260
gcgaatccca aaaataacgt cccagttcgg actgcagtct gcaactcgac tgcacgaagc 1320
tggaatcgct agtaatcgcg gatcagaatg ccgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagtcagta acgcccgaag tcagtgacct aaccgaaagg 1440
aaggagctgc cgaaggcggg accgataact ggggtgaagt cgtaacaagg tagccgtatc 1500
ggaaggtgcg gctggatccc c 1521
<210> 153
<211> 1501
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 153
ttgagagttt gatcctggct caggatgaac gctggcggcg tgcctaacac atgcaagttg 60
agcgatttac ttcggtaaag agcggcggac gggtgagtaa cgcgtgggta acctaccctg 120
tacacacgga taacataccg aaaggtatgc taatacggga taatatattt gagaggcatc 180
tcttaaatat caaaggtgag ccagtacagg atggacccgc gtctgattag ctagttggta 240
aggtaacggc ttaccaaggc gacgatcagt agccgacctg agagggtgat cggccacatt 300
ggaactgaga cacggtccaa actcctacgg gaggcagcag tggggaatat tgcacaatgg 360
gcgaaagcct gatgcagcaa cgccgcgtga gtgatgaagg ccttcgggtc gtaaaactct 420
gtcctcaagg aagataatga cggtacttga ggaggaagcc ccggctaact acgtgccagc 480
agccgcggta atacgtaggg ggctagcgtt atccggattt actgggcgta aagggtgcgt 540
aggcggtctt tcaagtcagg agtgaaaggc tacggctcaa ccgtagtaag ctcttgaaac 600
tgggagactt gagtgcagga gaggagagtg gaattcctag tgtagcggtg aaatgcgtag 660
atattaggag gaacaccagt tgcgaaggcg gctctctgga ctgtaactga cgctgaggca 720
cgaaagcgtg gggagcaaac aggattagat accctggtag tccacgctgt aaacgatgag 780
tactaggtgt cgggggttac ccccttcggt gccgcagcta acgcattaag tactccgcct 840
gggaagtacg ctcgcaagag tgaaactcaa aggaattgac ggggacccgc acaagtagcg 900
gagcatgtgg tttaattcga agcaacgcga agaaccttac ctaagcttga catcccaatg 960
acatctcctt aatcggagag ttcccttcgg ggacattggt gacaggtggt gcatggttgt 1020
cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgtcttt 1080
agttgccatc attaagttgg gcactctaga gagactgcca gggataacct ggaggaaggt 1140
ggggatgacg tcaaatcatc atgcccctta tgcttagggc tacacacgtg ctacaatggg 1200
tagtacagag ggttgccaag ccgtaaggtg gagctaatcc cttaaagcta ctctcagttc 1260
ggattgtagg ctgaaactcg cctacatgaa gctggagtta ctagtaatcg cagatcagaa 1320
tgctgcggtg aatgcgttcc cgggtcttgt acacaccgcc cgtcacacca cgggagttgg 1380
agacgcccga agccgattat ctaacctttt ggaagaagtc gtcgaaggtg gaatcaataa 1440
ctggggtgaa gtcgtaacaa ggtagccgta tcggaaggtg cggctggatc acctcctttc 1500
t 1501
<210> 154
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 154
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa tatatttgag aggcatctct 180
tgaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taacggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cttcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaat cggagagttc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgccaagccg taaggtggag ctaatccctt aaagctactc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccacgg gagttggaga 1380
cgcccgaagc cgattatcta accttttgga agaagtcgtc gaaggtggaa tcaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctg 1483
<210> 155
<211> 1466
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<220>
<221> misc_feature
<222> (467)..(467)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1290)..(1290)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1335)..(1335)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1402)..(1402)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1405)..(1405)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1435)..(1435)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1438)..(1438)
<223> n is a, c, g, or t
<400> 155
atcatkgctc abgatgaacg ctggcggcgt gcctaacaca tgcaagttga gcgatttact 60
tcggtaaaga gcggcggacg ggtgagtaac gcgtgggtaa cctaccctgt acacacggat 120
aacataccga aaggtatgct aatacgggat aatatatttg agaggcatct cttgaatatc 180
aaaggtgagc cagtacagga tggacccgcg tctgattagc tagttggtaa ggtaacggct 240
taccaaggcg acgatcagta gccgacctga gagggtgatc ggccacattg gaactgagac 300
acggtccaaa ctctacggga ggcagcagtg gggaatattg cacaatgggc gaaagcctga 360
tgcagcaacg ccgcgtgagt gatgaaggcc ttcgggtcgt aaaactctgt cctcaaggaa 420
gataatgacg gtacttgagg aggaagcccc ggctaactac gtgccancag ccgcggtaat 480
acgtaggggg ctagcgttat ccggatttac tgggcgtaaa gggtgcgtag gcggtctttc 540
aagtcaggag tgaaaggcta cggctcaacc gtagtaagct cttgaaactg ggagacttga 600
gtgcaggaga ggagagtgga attcctagtg tagcggtgaa atgcgtagat attaggagga 660
acaccagttg cgaaggcggc tctctggact gtaactgacg ctgaggcacg aaagcgtggg 720
gagcaaacag gattagatac cctggtagtc cacgctgtaa acgatgagta ctaggtgtcg 780
ggggttaccc cttcggtgcc gcactaacgc attaagtact ccgcctggga agtacgctcg 840
caagagtgaa actcaaagga attgacgggg acccgcacaa gtagcggagc atgtggttta 900
attcgaagca acgcgaagaa ccttacctaa gcttgacatc ccaatgacat ctccttaatc 960
ggagagttcc cttcggggac attggtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 1020
gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gtctttagtt gccatcatta 1080
agttgggcac tctagagaga ctgccaggga taacctggag gaaggtgggg atgacgtcaa 1140
atcatcatgc cccttatgct tagggctaca cacgtgctac aatgggtagt acagagggtt 1200
gccaagccgt aaggtggagc taatccctta aagctactct cagttcggat tgtaggctga 1260
aactcgccta catgaagctg gagttactan taatcgcaat caaaatgctg cggtgaatgc 1320
gttcccgggg tcttntacac accgcccgtc acaccacggg agttggaaac gcccgaagcc 1380
gaattatcta accttttgga anaantcstc gaaagtggaa tcaataactt gggtnaantc 1440
gtaacaaggt aaccgtatcg gaaggt 1466
<210> 156
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 156
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa tatatttgag aggcatctct 180
tgaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taacggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cttcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaat cggagagctc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgccaagccg taaggtggag ctaatccctt aaagctactc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccacgg aagttggaga 1380
cgcccgaagc cgattatcta accttttgga agaagtcgtc gaaggtggaa tcaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctg 1483
<210> 157
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 157
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa tatatttgag aggcatctct 180
tgaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taacggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cctcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaat cggagagttc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgccaagccg taaggtggag ctaatccctt aaagctactc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccacgg gagttggaga 1380
cgcccgaagc cgattatcta accttttgga agaagtcgtc gaaggtggaa tcaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctg 1483
<210> 158
<211> 1630
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 158
gaacattgaa aattaaacag taggttaatt tatattaaga aacaaaccat aaagccagat 60
attttgataa caatagtatc tgagcctgat aaacttttat ttgagagttt gatcctggct 120
caggatgaac gctggcggcg tgcctaacac atgcaagttg agcgatttac ttcggtaaag 180
agcggcggac gggtgagtaa cgcgtgggta acctaccctg tacacacgga taacataccg 240
aaaggtatgc taatacggga taatatattt gagaggcatc tcttaaatat caaaggtgag 300
ccagtacagg atggacccgc gtctgattag ctagttggta aggtaacggc ttaccaaggc 360
gacgatcagt agccgacctg agagggtgat cggccacatt ggaactgaga cacggtccaa 420
actcctacgg gaggcagcag tggggaatat tgcacaatgg gcgaaagcct gatgcagcaa 480
cgccgcgtga gtgatgaagg ccttcgggtc gtaaaactct gtcctcaagg aagataatga 540
cggtacttga ggaggaagcc ccggctaact acgtgccagc agccgcggta atacgtaggg 600
ggctagcgtt atccggattt actgggcgta aagggtgcgt aggcggtctt tcaagtcagg 660
agtgaaaggc tacggctcaa ccgtagtaag ctcttgaaac tgggagactt gagtgcagga 720
gaggagagtg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 780
tgcgaaggcg gctctctgga ctgtaactga cgctgaggca cgaaagcgtg gggagcaaac 840
aggattagat accctggtag tccacgctgt aaacgatgag tactaggtgt cgggggttac 900
ccccttcggt gccgcagcta acgcattaag tactccgcct gggaagtacg ctcgcaagag 960
tgaaactcaa aggaattgac ggggacccgc acaagtagcg gagcatgtgg tttaattcga 1020
agcaacgcga agaaccttac ctaagcttga catcccaatg acatctcctt aatcggagag 1080
ttcccttcgg ggacattggt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 1140
tgttgggtta agtcccgcaa cgagcgcaac ccttgtcttt agttgccatc attaagttgg 1200
gcactctaga gagactgcca gggataacct ggaggaaggt ggggatgacg tcaaatcatc 1260
atgcccctta tgcttagggc tacacacgtg ctacaatggg tagtacagag ggttgccaag 1320
ccgtaaggtg gagctaatcc cttaaagcta ctctcagttc ggattgtagg ctgaaactcg 1380
cctacatgaa gctggagtta ctagtaatcg cagatcagaa tgctgcggtg aatgcgttcc 1440
cgggtcttgt acacaccgcc cgtcacacca cgggagttgg agacgcccga agccgattat 1500
ctaacctttt ggaagaagtc gtcgaaggtg gaatcaataa ctggggtgaa gtcgtaacaa 1560
ggtagccgta tcggaaggtg cggctggatc acctcctttc taaggagaat tgcctactgt 1620
ttaattttga 1630
<210> 159
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 159
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa tatatttgag aggcatctct 180
tgaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taacggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cttcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaat cggagagttc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgccaagccg taaggtggag ctaatccctt aaagctactc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccacgg gagttggaga 1380
cgcccgaagc cgactatcta accttttgga agaagtcgtc gaaggtggaa tcaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctg 1483
<210> 160
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 160
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa catatttgag aggcatctct 180
taaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taacggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cttcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaac cggagagttc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgccaaaccg taaggtggag ctaatccctt aaagctactc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccacgg gagttggaga 1380
cgcccgaagc cgattatcta accttttgga agaagtcgtc gaaggtggaa tcaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctg 1483
<210> 161
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 161
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa tatatttgag aggcatctct 180
tgaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taaaggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cttcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaat cggagagttc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgccaagccg taaggtggag ctaatccctt aaagctactc tcagttcgga 1260
ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcag atcagaatgc 1320
tgcggtgaat gcgttcccgg gtcttgtaca caccgcccgt cacaccacgg gagttggaga 1380
cgcccgaagc cgattatcta accttttgga agaagtcgtc gaaggtggaa tcaataactg 1440
gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctg 1483
<210> 162
<211> 1214
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 162
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagttgagc 60
gatttacttc ggtaaagagc ggcggacggg tgagtaacgc gtgggtaacc taccctgtac 120
acacggataa cataccgaaa ggtatgctaa tacgggataa catatttgag aggcatctct 180
taaatatcaa aggtgagcca gtacaggatg gacccgcgtc tgattagcta gttggtaagg 240
taacggctta ccaaggcgac gatcagtagc cgacctgaga gggtgatcgg ccacattgga 300
actgagacac ggtccaaact cctacgggag gcagcagtgg ggaatattgc acaatgggcg 360
aaagcctgat gcagcaacgc cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc 420
ctcaaggaag ataatgacgg tacttgagga ggaagccccg gctaactacg tgccagcagc 480
cgcggtaata cgtagggggc tagcgttatc cggatttact gggcgtaaag ggtgcgtagg 540
cggtctttca agtcaggagt gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg 600
gagacttgag tgcaggagag gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata 660
ttaggaggaa caccagttgc gaaggcggct ctctggactg taactgacgc tgaggcacga 720
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgagtac 780
taggtgtcgg gggttacccc cctcggtgcc gcagctaacg cattaagtac tccgcctggg 840
aagtacgctc gcaagagtga aactcaaagg aattgacggg gacccgcaca agtagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta agcttgacat cccaatgaca 960
tctccttaat cggagagttc ccttcgggga cattggtgac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgtctttagt 1080
tgccatcatt aagttgggca ctctagagag actgccaggg ataacctgga ggaaggtggg 1140
gatgacgtca aatcatcatg ccccttatgc ttagggctac acacgtgcta caatgggtag 1200
tacagagggt tgcc 1214
<210> 163
<211> 1507
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 163
ttttatttga gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc 60
aagttgagcg atttacttcg gtaaagagcg gcggacgggt gagtaacgcg tgggtaacct 120
accctgtaca cacggataac ataccgaaag gtatgctaat acgggataac atatttgaga 180
ggcatctctt gaatatcaaa ggtgagccag tacaggatgg acccgcgtct gattagctag 240
ttggtaaggt aacggcttac caaggcgacg atcagtagcc gacctgagag ggtgatcggc 300
cacattggaa ctgagacacg gtccaaactc ctacgggagg cagcagtggg gaatattgca 360
caatgggcga aagcctgatg cagcaacgcc gcgtgagtga tgaaggcctt cgggtcgtaa 420
aactctgtcc tcaaggaaga taatgacggt acttgaggag gaagccccgg ctaactacgt 480
gccagcagcc gcggtaatac gtagggggct agcgttatcc ggatttactg ggcgtaaagg 540
gtgcgtaggc ggtctttcaa gtcaggagtg aaaggctacg gctcaaccgt agtaagctct 600
tgaaactggg agacttgagt gcaggagagg agagtggaat tcctagtgta gcggtgaaat 660
gcgtagatat taggaggaac accagttgcg aaggcggctc tctggactgt aactgacgct 720
gaggcacgaa agcgtgggga gcaaacagga ttagataccc tggtagtcca cgctgtaaac 780
gatgagtact aggtgtcggg ggttaccccc ctcggtgccg cagctaacgc attaagtact 840
ccgcctggga agtacgctcg caagagtgaa actcaaagga attgacgggg acccgcacaa 900
gtagcggagc atgtggttta attcgaagca acgcgaagaa ccttacctaa gcttgacatc 960
ccaatgacat ctccttaatc ggagagttcc cttcggggac attggtgaca ggtggtgcat 1020
ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt 1080
gtctttagtt gccatcatta agttgggcac tctagagaga ctgccaggga taacctggag 1140
gaaggtgggg atgacgtcaa atcatcatgc cccttatgct tagggctaca cacgtgctac 1200
aatgggtagt acagagggtt gccaaaccgt aaggtggagc taatccctta aagctactct 1260
cagttcggat tgtaggctga aactcgccta catgaagctg gagttactag taatcgcaga 1320
tcagaatgct gcggtgaatg cgttcccggg tcttgtacac accgcccgtc acaccacggg 1380
agttggagac gcccgaagcc gattatctaa ccttttggaa gaagtcgtcg aaggtggaat 1440
caataactgg ggtgaagtcg taacaaggta gccgtatcgg aaggtgcggc tggatcacct 1500
cctttct 1507
<210> 164
<211> 1418
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 164
ggcggacggg tgagtaacgc gtgggtaacc taccctgtac acacggataa cataccgaaa 60
ggtatgctaa tacgggataa catatttgag aggcatctct tgaatatcaa aggtgagcca 120
gtacaggatg gacccgcgtc tgattagcta gttggtaagg taacggctta ccaaggcgac 180
gatcagtagc cgacctgaga gggtgatcgg ccacattgga actgagacac ggtccaaact 240
cctacgggag gcagcagtgg ggaatattgc acaatgggcg aaagcctgat gcagcaacgc 300
cgcgtgagtg atgaaggcct tcgggtcgta aaactctgtc ctcaaggaag ataatgacgg 360
tacttgagga ggaagccccg gctaactacg tgccagcagc cgcggtaata cgtagggggc 420
tagcgttatc cggatttact gggcgtaaag ggtgcgtagg cggtctttca agtcaggagt 480
gaaaggctac ggctcaaccg tagtaagctc ttgaaactgg gagacttgag tgcaggagag 540
gagagtggaa ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagttgc 600
gaaggcggct ctctggactg taactgacgc tgaggcacga aagcgtgggg agcaaacagg 660
attagatacc ctggtagtcc acgctgtaaa cgatgagtac taggtgtcgg gggttacccc 720
cctcggtgcc gcagctaacg cattaagtac tccgcctggg aagtacgctc gcaagagtga 780
aactcaaagg aattgacggg gacccgcaca agtagcggag catgtggttt aattcgaagc 840
aacgcgaaga accttaccta agcttgacat cccaatgaca tctccttaat cggagagttc 900
ccttcgggga cattggtgac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt 960
tgggttaagt cccgcaacga gcgcaaccct tgtctttagt tgccatcatt aagttgggca 1020
ctctagagag actgccaggg ataacctgga ggaaggtggg gatgacgtca aatcatcatg 1080
ccccttatgc ttagggctac acacgtgcta caatgggtag tacagagggt tgccaaaccg 1140
taaggtggag ctaatccctt aaagctactc tcagttcgga ttgtaggctg aaactcgcct 1200
acatgaagct ggagttacta gtaatcgcag atcagaatgc tgcggtgaat gcgttcccgg 1260
gtcttgtaca caccgcccgt cacaccacgg gagttggaga cgcccgaagc cgattatcta 1320
accttttgga agaagtcgtc gaaggtggaa tcaataactg gggtgaagtc gtaacaaggt 1380
agccgtatcg gaaggtgcgg ctggatcacc tcctttct 1418
<210> 165
<211> 1507
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 165
ttttatttga gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc 60
aagttgagcg atttacttcg gtaaagagcg gcggacgggt gagtaacgcg tgggtaacct 120
accctgtaca cacggataac ataccgaaag gtatgctaat acgggataat atatttgaga 180
ggcatctctt gaatatcaaa ggtgagccag tacaggatgg acccgcgtct gattagctag 240
ttggtaaggt aacggcttac caaggcgacg atcagtagcc gacctgagag ggtgatcggc 300
cacattggaa ctgagacacg gtccaaactc ctacgggagg cagcagtggg gaatattgca 360
caatgggcga aagcctgatg cagcaacgcc gcgtgagtga tgaaggcctt cgggtcgtaa 420
aactctgtcc tcaaggaaga taatgacggt acttgaggag gaagccccgg ctaactacgt 480
gccagcagcc gcggtaatac gtagggggct agcgttatcc ggatttactg ggcgtaaagg 540
gtgcgtaggc ggtctttcaa gtcaggagtg aaaggctacg gctcaaccgt agtaagctct 600
tgaaactggg agacttgagt gcaggagagg agagtggaat tcctagtgta gcggtgaaat 660
gcgtagatat taggaggaac accagttgcg aaggcggctc tctggactgt aactgacgct 720
gaggcacgaa agcgtgggga gcaaacagga ttagataccc tggtagtcca cgctgtaaac 780
gatgagtact aggtgtcggg ggttaccccc ttcggtgccg cagctaacgc attaagtact 840
ccgcctggga agtacgctcg caagagtgaa actcaaagga attgacgggg acccgcacaa 900
gtagcggagc atgtggttta attcgaagca acgcgaagaa ccttacctaa gcttgacatc 960
ccaatgacat ctccttaatc ggagagttcc cttcggggac attggtgaca ggtggtgcat 1020
ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt 1080
gtctttagtt gccatcatta agttgggcac tctagagaga ctgccaggga taacctggag 1140
gaaggtgggg atgacgtcaa atcatcatgc cccttatgct tagggctaca cacgtgctac 1200
aatgggtagt acagagggtt gccaagccgt aaggtggagc taatccctta aagctactct 1260
cagttcggat tgtaggctga aactcgccta catgaagctg gagttactag taatcgcaga 1320
tcagaatgct gcggtgaatg cgttcccggg tcttgtacac accgcccgtc acaccacggg 1380
agttggagac gcccgaagcc gattatctaa ccttttggaa gaagtcgtcg aaggtggaat 1440
caataactgg ggtgaagtcg taacaaggta gccgtatcgg aaggtgcggc tggatcacct 1500
cctttct 1507
<210> 166
<211> 1501
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<220>
<221> misc_feature
<222> (1403)..(1403)
<223> n is a, c, g, or t
<400> 166
ttgagagttt gatcctggct caggatgaac gctggcggcg tgcctaacac atgcaagttg 60
agcgatttac ttcggtaaag agcggcggac gggtgagtaa cgcgtgggta acctaccctg 120
tacacacgga taacataccg aaaggtatgc taatacggga taatatattt gagaggcatc 180
tcttaaatat caaaggtgag ccagtacagg atggacccgc gtctgattag ctagttggta 240
aggtaacggc ttaccaaggc gacgatcagt agccgacctg agagggtgat cggccacatt 300
ggaactgaga cacggtccaa actcctacgg gaggcagcag tggggaatat tgcacaatgg 360
gcgaaagcct gatgcagcaa cgccgcgtga gtgatgaagg ccttcgggtc gtaaaactct 420
gtcctcaagg aagataatga cggtacttga ggaggaagcc ccggctaact acgtgccagc 480
agccgcggta atacgtaggg ggctagcgtt atccggattt actgggcgta aagggtgcgt 540
aggcggtctt tcaagtcagg agtgaaaggc tacggctcaa ccgtagtaag ctcttgaaac 600
tgggagactt gagtgcagga gaggagagtg gaattcctag tgtagcggtg aaatgcgtag 660
atattaggag gaacaccagt tgcgaaggcg gctctctgga ctgtaactga cgctgaggca 720
cgaaagcgtg gggagcaaac aggattagat accctggtag tccacgctgt aaacgatgag 780
tactaggtgt cgggggttac ccccttcggt gccgcagcta acgcattaag tactccgcct 840
gggaagtacg ctcgcaagag tgaaactcaa aggaattgac ggggacccgc acaagtagcg 900
gagcatgtgg tttaattcga agcaacgcga agaaccttac ctaagcttga catcccaatg 960
acatctcctt aatcggagag ttcccttcgg ggacgttggt gacaggtggt gcatggttgt 1020
cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgtcttt 1080
agttgccatc attaagttgg gcactctaga gagactgcca gggataacct ggaggaaggt 1140
ggggatgacg tcaaatcatc atgcccctta tgcttagggc tacacacgtg ctacaatggg 1200
tagtacagag ggttgccaag ccgtaaggtg gagctaatcc cttaaagcta ctctcagttc 1260
ggattgtagg ctgaaactcg cctacatgaa gctggagtta ctagtaatcg cagatcagaa 1320
tgctgcggtg aatgcgttcc cgggtcttgt acacaccgcc cgtcacacca cgggagttgg 1380
agacgcccga agccgactat ctnacctttt ggaagaagtc gtcgaaggtg gaatcaataa 1440
ctggggtgaa gtcgtaacaa ggtagccgta tcggaaggtg cggctggatc acctcctttc 1500
t 1501
<210> 167
<211> 1501
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 167
ttgagagttt gatcctggct caggatgaac gctggcggcg tgcctaacac atgcaagttg 60
agcgatttac ttcggtaaag agcggcggac gggtgagtaa cgcgtgggta acctaccctg 120
tacacacgga taacataccg aaaggtatgc taatacggga taatatattt gagaggcatc 180
tcttgaatat caaaggtgag ccagtacagg atggacccgc gtctgattag ctagttggta 240
aggtaacggc ttaccaaggc gacgatcagt agccgacctg agagggtgat cggccacatt 300
ggaactgaga cacggtccaa actcctacgg gaggcagcag tggggaatat tgcacaatgg 360
gcgaaagcct gatgcagcaa cgccgcgtga gtgatgaagg ccttcgggtc gtaaaactct 420
gtcctcaagg aagataatga cggtacttga ggaggaagcc ccggctaact acgtgccagc 480
agccgcggta atacgtaggg ggctagcgtt atccggattt actgggcgta aagggtgcgt 540
aggcggtctt tcaagtcagg agtgaaaggc tacggctcaa ccgtagtaag ctcttgaaac 600
tgggagactt gagtgcagga gaggagagtg gaattcctag tgtagcggtg aaatgcgtag 660
atattaggag gaacaccagt tgcgaaggcg gctctctgga ctgtaactga cgctgaggca 720
cgaaagcgtg gggagcaaac aggattagat accctggtag tccacgctgt aaacgatgag 780
tactaggtgt cgggggttac ccccttcggt gccgcagcta acgcattaag tactccgcct 840
gggaagtacg ctcgcaagag tgaaactcaa aggaattgac ggggacccgc acaagtagcg 900
gagcatgtgg tttaattcga agcaacgcga agaaccttac ctaagcttga catcccaatg 960
acatctcctt aatcggagag ttcccttcgg ggacattggt gacaggtggt gcatggttgt 1020
cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgtcttt 1080
agttgccatc attaagttgg gcactctaga gagactgcca gggataacct ggaggaaggt 1140
ggggatgacg tcaaatcatc atgcccctta tgcttagggc tacacacgtg ctacaatggg 1200
tagtacagag ggttgccaag ccgtaaggtg gagctaatcc cttaaagcta ctctcagttc 1260
ggattgtagg ctgaaactcg cctacatgaa gctggagtta ctagtaatcg cagatcagaa 1320
tgctgcggtg aatgcgttcc cgggtcttgt acacaccgcc cgtcacacca cgggagttgg 1380
agacgcccga agccgattat ctaacctttt ggaagaagtc gtcgaaggtg gaatcaataa 1440
ctggggtgaa gtcgtaacaa ggtagccgta tcggaaggtg cggctggatc acctcctttc 1500
t 1501
<210> 168
<211> 1501
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 168
ttgagagttt gatcctggct caggatgaac gctggcggcg tgcctaacac atgcaagttg 60
agcgatttac ttcggtaaag agcggcggac gggtgagtaa cgcgtgggta acctaccctg 120
tacacacgga taacataccg aaaggtatgc taatacggga taatatattt gagaggcatc 180
tcttaaatat caaaggtgag ccagtacagg atggacccgc gtctgattag ctagttggta 240
aggtaacggc ttaccaaggc gacgatcagt agccgacctg agagggtgat cggccacatt 300
ggaactgaga cacggtccaa actcctacgg gaggcagcag tggggaatat tgcacaatgg 360
gcgaaagcct gatgcagcaa cgccgcgtga gtgatgaagg ccttcgggtc gtaaaactct 420
gtcctcaagg aagataatga cggtacttga ggaggaagcc ccggctaact acgtgccagc 480
agccgcggta atacgtaggg ggctagcgtt atccggattt actgggcgta aagggtgcgt 540
aggcggtctt tcaagtcagg agtgaaaggc tacggctcaa ccgtagtaag ctcttgaaac 600
tgggagactt gagtgcagga gaggagagtg gaattcctag tgtagcggtg aaatgcgtag 660
atattaggag gaacaccagt tgcgaaggcg gctctctgga ctgtaactga cgctgaggca 720
cgaaagcgtg gggagcaaac aggattagat accctggtag tccacgctgt aaacgatgag 780
tactaggtgt cgggggttac ccccttcggt gccgcagcta acgcattaag tactccgcct 840
gggaagtacg ctcgcaagag tgaaactcaa aggaattgac ggggacccgc acaagtagcg 900
gagcatgtgg tttaattcga agcaacgcga agaaccttac ctaagcttga catcccaatg 960
acatctcctt aatcggagag ttcccttcgg ggacattggt gacaggtggt gcatggttgt 1020
cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgtcttt 1080
agttgccatc attaagttgg gcactctaga gagactgcca gggataacct ggaggaaggt 1140
ggggatgacg tcaaatcatc atgcccctta tgcttagggc tacacacgtg ctacaatggg 1200
tagtacagag ggttgccaag ccgtaaggtg gagctaatcc cttaaagcta ctctcagttc 1260
ggattgtagg ctgaaactcg cctacatgaa gctggagtta ctagtaatcg cagatcagaa 1320
tgctgcggtg aatgcgttcc cgggtcttgt acacaccgcc cgtcacacca cggaagttgg 1380
agacgcccga agccgattat ctaacctttt ggaagaagtc gtcgaaggtg gaatcaataa 1440
ctggggtgaa gtcgtaacaa ggtagccgta tcggaaggtg cggctggatc acctcctttc 1500
t 1501
<210> 169
<211> 1462
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_difficile
<400> 169
agtttgatcc tggctcagga tgaacgctgg cggcgtgcct aacacatgca agttgagcga 60
tttacttcgg taaagagcgg cggacgggtg agtaacgcgt gggtaaccta ccctgtacac 120
acggataaca taccgaaagg tatgctaata cgggataata tatttgagag gcatctcttg 180
aatatcaaag gtgagccagt acaggatgga cccgcgtctg attagctagt tggtaaggta 240
acggcttacc aaggcgacga tcagtagccg acctgagagg gtgatcggcc acattggaac 300
tgagacacgg tccaaactcc tacgggaggc agcagtgggg aatattgcac aatgggcgaa 360
agcctgatgc agcaacgccg cgtgagtgat gaaggccttc gggtcgtaaa actctgtcct 420
caaggaagat aatgacggta cttgaggagg aagccccggc taactacgtg ccagcagccg 480
cggtaatacg tagggggcta gcgttatccg gatttactgg gcgtaaaggg tgcgtaggcg 540
gtctttcaag tcaggagtga aaggctacgg ctcaaccgta gtaagctctt gaaactggga 600
gacttgagtg caggagagga gagtggaatt cctagtgtag cggtgaaatg cgtagatatt 660
aggaggaaca ccagttgcga aggcggctct ctggactgta actgacgctg aggcacgaaa 720
gcgtggggag caaacaggat tagataccct ggtagtccac gctgtaaacg atgagtacta 780
ggtgtcgggg gttaccccct tcggtgccgc agctaacgca ttaagtactc cgcctgggaa 840
gtacgctcgc aagagtgaaa ctcaaaggaa ttgacgggga cccgcacaag tagcggagca 900
tgtggtttaa ttcgaagcaa cgcgaagaac cttacctaag cttgacatcc caatgacatc 960
tccttaatcg gagagttccc ttcggggaca ttggtgacag gtggtgcatg gttgtcgtca 1020
gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaacccttg tctttagttg 1080
ccatcattaa gttgggcact ctagagagac tgccagggat aacctggagg aaggtgggga 1140
tgacgtcaaa tcatcatgcc ccttatgctt agggctacac acgtgctaca atgggtagta 1200
cagagggttg ccaagccgta aggtggagct aatcccttaa agctactctc agttcggatt 1260
gtaggctgaa actcgcctac atgaagctgg agttactagt aatcgcagat cagaatgctg 1320
cggtgaatgc gttcccgggt cttgtacaca ccgcccgtca caccacggga gttggagacg 1380
cccgaagccg attatctaac cttttggaag aagtcgtcga aggtggaatc aataactggg 1440
gtgaagtcgt aacaaggtaa cc 1462
<210> 170
<211> 1472
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_disporicum
<400> 170
gctcaggacg aacgctggcg gcgtgcctaa cacatgcaag tcgagcgagt tgattctctt 60
cggagatgaa gctagcggcg gacgggtgag taacacgtgg gcaacctgcc tcatagaggg 120
gaatagcctc ccgaaaggga gattaatacc gcataagatt gtagcttcgc atgaagtagc 180
aattaaagga gcaatccgct atgagatggg cccgcggcgc attagctagt tggtgaggta 240
acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc acattgggac 300
tgagacacgg cccagactcc tacgggaggc agcagtgggg aatattgcac aatgggggaa 360
accctgatgc agcaacgccg cgtgagtgat gacggccttc gggttgtaaa gctctgtctt 420
cagggacgat aatgacggta cctgaggagg aagccacggc taactacgtg ccagcagccg 480
cggtaatacg taggtggcga gcgttgtccg gatttactgg gcgtaaaggg agcgtaggcg 540
gacttttaag tgagatgtga aatacccggg ctcaacttgg gtgctgcatt tcaaactgga 600
agtctagagt gcaggagagg agaatggaat tcctagtgta gcggtgaaat gcgtagagat 660
taggaagaac accagtggcg aaggcgattc tctggactgt aactgacgct gaggctcgaa 720
agcgtgggga gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgaatact 780
aggtgtaggg gttgtcatga cctctgtgcc gccgctaacg cattaagtat tccgcctggg 840
gagtacggtc gcaagattaa aactcaaagg aattgacggg ggcccgcaca agcagcggag 900
catgtggttt aattcgaagc aacgcgaaga accttaccta gacttgacat ctcctgaatt 960
acccgtaact ggggaagcca cttcggtggc aggaagacag gtggtgcatg gttgtcgtca 1020
gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaaccctta ttgttagttg 1080
ctaccattta gttgagcact ctagcgagac tgcccgggtt aaccgggagg aaggtgggga 1140
tgacgtcaaa tcatcatgcc ccttatgtct agggctacac acgtgctaca atggcaagta 1200
caaagagaag caagaccgcg aggtggagca aaactcaaaa acttgtctca gttcggattg 1260
taggctgaaa ctcgcctaca tgaagctgga gttgctagta atcgcgaatc agcatgtcgc 1320
ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac accatgagag ttggcaatac 1380
ccaacgtacg tgatctaacc cgcaagggag gaagcgtcct aaggtagggt cagcgattgg 1440
ggtgaagtcg taacaaggta gccgtaggag aa 1472
<210> 171
<211> 1266
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_disporicum
<400> 171
catgcaagtc gagcgagcgg cggacgggtg agtaacacgt gggcaacctg cctcatagag 60
gggaatagcc tcccgaaagg gagattaata ccgcataagt aaagccgcta tgagatgggc 120
ccgcggcgca ttagctagtt ggtgaggtaa cggctcacca aggcgacgat gcgtagccga 180
cctgagaggg tgatcggcca cattgggact gagacacggc ccagactcct acgggaggca 240
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcaacgccgc gtgagtgatg 300
acggccttcg ggttgtaaag ctctgtcttc agggacgatg acggtacctg aggaggaagc 360
cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcgagcgt tgtccggatt 420
tactgggcgt aaagggagcg taggcggact tttaagtgag atgtgaaata cccgggctca 480
acttgggtgc tgcatttcaa actggaagtc tagagtgcag gagaggagaa tggaattcct 540
agtgtagcgg tgaaatgcgt agagattagg aagaacacca gtggcgaagg cgattctctg 600
gactgactga cgctgaggct cgaaagcgtg gggagcaaac aggattagat accctggtag 660
tccacgccgt aaacgatgaa tactaggtgt aggggcctct gtgccgccgc taacgcatta 720
agtattccgc ctggggagta cggtcgcaag attaaaactc aaaggaattg acgggggccc 780
gcacaagcag cggagcatgt ggtttaattc gaagcaacgc gaagaacctt acctagactt 840
gacatcgaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 900
ccgcaacgag cgcaaccctt attgttagtt gctaccatga gcactctagc gagactgccc 960
gggttaaccg ggaggaaggt ggggatgacg tcaaatcatc atgcccctta tgtctagggc 1020
tacacacgtg ctacaatggc aagcaaagag aagcaagacc gcgaggtgga gcaaaactca 1080
cttgtctcag ttcggatgta ggctgaaact cgcctacaga agctggagtt gctagtaatc 1140
gcgaatcagc atgtcgcggt gaatacgttc ccgggccttg tacacaccgc ccgtcacacc 1200
atgagagttg gcaataccca acgtacgtat ctaggaagcg tcctaaggta gggtcagcga 1260
ttgggg 1266
<210> 172
<211> 1463
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_ghonii
<400> 172
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc 60
gattccttcg ggaagagcgg cggacgggtg agtaacgcgt gggtaacctg ccctgtacac 120
acggataaca taccgaaagg tatgctaata cgggataaaa tatgaaagtt gcataacttt 180
catatcaaag cttttgcggt acaggatgga cccgcgtctg attagctagt tggtaaggta 240
acggcttacc aaggcaacga tcagtagccg acctgagagg gtgatcggcc acactggaac 300
tgagacacgg tccagactcc tacgggaggc agcagtgggg aatattgcac aatgggcgaa 360
agcctgatgc agcaacgccg cgtgagcgat gaaggccttc gggtcgtaaa gctctgtcct 420
caaggaagat aatgacggta cttgaggagg aagccccggc taactacgtg ccagcagccg 480
cggtaatacg tagggggcta gcgttatccg gaattactgg gcgtaaaggg tgcgtaggcg 540
gtctttcaag ccagaagtga aaggctacgg ctcaaccgta gtaagctttt ggaactgtag 600
gacttgagtg caggagagga gagtggaatt cctagtgtag cggtgaaatg cgtagatatt 660
aggaggaaca ccagtagcga aggcggctct ctggactgta actgacgctg aggcacgaaa 720
gcgtggggag cgaacaggat tagataccct ggtagtccac gccgtaaacg atgagtacta 780
ggtgtcgggg gttacccccc tcggtgccgc agctaacgca ttaagtactc cgcctgggaa 840
gtacgctcgc aagagtgaaa ctcaaaggaa ttgacgggga cccgcacaag tagcggagca 900
tgtggtttaa ttcgaagcaa cgcgaagaac cttacctaag cttgacatcc cattgacctc 960
tccctaatcg gagatttccc ttcggggaca gtggagacag gtggtgcatg gttgtcgtca 1020
gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaacccttg cctttagttg 1080
ccagcattaa gttgggcact ctagagggac tgccgaggat aactcggagg aaggtgggga 1140
tgacgtcaaa tcatcatgcc ccttatgctt agggctacac acgtgctaca atgggtggta 1200
cagagggttg ccaagccgcg aggtggagct aatcccttaa agccattctc agttcggatt 1260
gtaggctgaa actcgcctac atgaagctgg agttactagt aatcgcagat cagaatgctg 1320
cggtgaatgc gttcccgggt cttgtacaca ccgcccgtca caccatggga gttgggggcg 1380
cccgaagccg gttagctaac cttttaggaa gcggccgtcg aaggtgaaac caatgactgg 1440
ggtgaagtcg taacaaggta acc 1463
<210> 173
<211> 1409
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_glycolicum
<400> 173
ctggcggcgt gcctaacaca tgcaagtcga gcgattcact tcggtgaaga gcggcggacg 60
ggtgagtaac gcgtgggtaa cctgcctcat acacatggat aacataccga aaggtatgct 120
aatacaggat aayataagaa attcacatgt atttcttatc aaagctccgg cggtatgaga 180
tggacccgcg tctgattagc tagttggtaa ggtaacggct taccaaggcg acgatcagta 240
gccgacctga gagggtgatc ggccacattg gaactgagac acggtccaaa ctcctacggg 300
aggcagcagt ggggaatatt gcacaatggg cgaaagcctg atgcagcaac gccgcgtgag 360
tgatgaaggc cttcgggtcg taaaactctg tcctcaagga agataatgac ggtacttgag 420
gaggaagccc cggctaacta cgtgccagca gccgcggtaa tacgtagggg gctagcgtta 480
tccggattta ctgggcgtaa agggtgcgta ggtggtttct taagtcagga gtgaaaggct 540
acggctcaac cgtagtaagc tcttgaaact gggagacttg agtgcaggag aggaaagtgg 600
aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagta gcgaaggcgg 660
ctttctggac tgtaactgac actgaggcac gaaagcgtgg ggagcgaaca ggattagata 720
ccctggtagt ccacgccgta aacgatgagt actaggtgtc gggggttacc cccctcggtg 780
ccgcagctaa cgcattaagt actccgcctg gggagtacgc tcgcaagagt gaaactcaaa 840
ggaattgacg gggacccgca caagtagcgg agcatgtggt ttaattcgaa gcaacgcgaa 900
gaaccttacc taagcttgac atccttttga ccgatgccta atcgcatttt tcccttcggg 960
gacagaagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 1020
gtcccgcaac gagcgcaacc cttgccttta gttgccagca ttaagttggg cactctagag 1080
ggactgccag ggataacctg gaggaaggtg gggatgacgt caaatcatca tgccccttat 1140
gcttagggct acacacgtgc tacaatgggt ggtacagagg gcagccaagt cgtgaggccg 1200
agctaatccc ttaaagccat tctcagttcg gattgtaggc tgaaactcgc ctacatgaag 1260
ctggagttac tagtaatcgc agatcagaat gctgcggtga atgcgttccc gggtcttgta 1320
cacaccgccc gtcacaccac ggaagttggg ggcgcccgaa gccacttagc taaccctttt 1380
gggaagcgag tgtcgaaggt gaaatcaat 1409
<210> 174
<211> 1389
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_glycyrrhizinilyticum
<400> 174
tagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcactt taccggattt cttcgggatg aaagttttgt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataaga ccacaggatt gcatgatccg gtggtaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attaggtagt tggtggggta acggctcacc aagccgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgat 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gagaggcaag tctgatgtga aaacccgggg 600
ctcaaccccg ggattgcatt ggaaactgct tttctagagt gtcggagagg taagtggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacgat gactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactgct aggtgtcggg gggcaaagcc tttcgtgccg 840
cagcaaacgc aataagcagt ccccctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 960
ccttacctgc ccttgacatc cggctgaccg gcgagtaatg tcgcctttcc ttcgggacag 1020
ccgagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccttat ctttagtagc cagcatttcg gatgggcact ctagagagac 1140
tgccagggat aacctggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgggc 1200
agggctacac acgtgctaca atggcgtaaa caaagggagg caagcctgcg agggtgagca 1260
aatcccaaaa ataacgtctc agttcggatt gtagtctgca actcgactac atgaagcagg 1320
aatcgctagt aatcgcgaat cagaatgtcg cggtgaatac gttcccgggt cttgtacaca 1380
ccgcccgtc 1389
<210> 175
<211> 1393
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_hiranonis
<400> 175
acatgcaagt cgagcgattc tcttcggaga agagcggcgg acgggtgagt aacgcgtggg 60
taacctgccc tgtacacacg gataacatac cgaaaggtat gctaatacgg gataatatat 120
aagagtcgca tgacttttat atcaaagatt tttcggtaca ggatggaccc gcgtctgatt 180
agcttgttgg cggggtaacg gcccaccaag gcgacgatca gtagccgacc tgagagggtg 240
atcggccaca ttggaactga gacacggtcc aaactcctac gggaggcagc agtggggaat 300
attgcacaat gggcgcaagc ctgatgcagc aacgccgcgt gagcgatgaa ggccttcggg 360
tcgtaaagct ctgtcctcaa ggaagataat gacggtactt gaggaggaag ccccggctaa 420
ctacgtgcca gcagccgcgg taatacgtag ggggctagcg ttatccggat ttactgggcg 480
taaagggtgc gtaggcggtc tttcaagtca ggagttaaag gctacggctc aaccgtagta 540
agctcctgat actgtctgac ttgagtgcag gagaggaaag cggaattccc agtgtagcgg 600
tgaaatgcgt agatattggg aggaacacca gtagcgaagg cggctttctg gactgtaact 660
gacgctgagg cacgaaagcg tggggagcaa acaggattag ataccctggt agtccacgct 720
gtaaacgatg agtactagtt gtcggaggtt accccttcgg tgccgcagct aacgcattaa 780
gtactccgcc tggggagtac gcacgcaagt gtgaaactca aaggaattga cggggacccg 840
cacaagtagc ggagcatgtg gtttaattcg aagcaacgcg aagaacctta cctaggcttg 900
acatccttct gaccgaggac taatctcctc tttccctccg gggacagaag tgacaggtgg 960
tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 1020
cccttgtctt tagttgccat cattaagttg ggcactctag agagactgcc agggataacc 1080
tggaggaagg tggggatgac gtcaaatcat catgcccctt atgcctaggg ctacacacgt 1140
gctacaatgg gtggtacaga gggcagccaa gccgtgaggt ggagcaaatc ccttaaagcc 1200
attctcagtt cggattgtag gctgaaactc gcctacatga agctggagtt actagtaatc 1260
gcagatcaga atgctgcggt gaatgcgttc ccgggtcttg tacacaccgc ccgtcacacc 1320
atgggagttg gagacacccg aagccgacta tctaaccttt tgggagaagt cgtccccctc 1380
gaatcaatac ccc 1393
<210> 176
<211> 1272
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_hylemonae
<400> 176
agtggcggac gggtgagtaa cgcgtgggca acctgcctta cacaggggga taacagctag 60
aaatggctgc taataccgca taagaaaaag tggtgtaaga tgggcccgcg tctgattagg 120
tagttggtag ggtaacggcc taccaagccg acgatcagta gccgacctga gagggtgacc 180
ggccacattg ggactgagac acggcccaaa ctcctacggg aggcagcagt ggggaatatt 240
gcacaatggg ggaaaccctg atgcagcgac gccgcgtgaa ggatgaagta tttcggtatg 300
taaacttcta tcagcaggga agatgacggt acctgactaa gaagccccgg ctaactacgt 360
gccagcagcc gcggtaatac gtagggggca agcgttatcc ggatttactg ggtgtaaagg 420
gagcgtagac ggcatggcaa gtctgaagtg aaagcccggg gctcaacccc gggactgctt 480
tggaaactgt caggctagag tgtcggagag gcaagtggaa ttcctagtgt agcggtgaaa 540
tgcgtagata ttaggaggaa caccagtggc gaaggcggct tgctggacga actgacgttg 600
aggctcgaaa gcgtggggag caaacaggat tagataccct ggtagtccac gccgtaaacg 660
atgattacta ggtgtcggga tttcggtgcc gcagccaacg caataagtaa tccacctggg 720
gagtacgttc gcaagaatga aactcaaagg aattgacggg gacccgcaca agcggtggag 780
catgtggttt aattcgaagc aacgcgaaga accttacctg atcttgacat cgacaggtgg 840
tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 900
cccttatctt tagtagccag catgtgggca ctctagagag actgccaggg ataacctgga 960
ggaaggtggg gatgacgtca aatcatcatg ccccttatga ccagggctac acacgtgcta 1020
caatggcgta caaagggaag cgaccctgtg aaggcaagca aatcccaaaa cgtctcagtt 1080
cggatgtagt ctgcaactcg actacagaag ctggaatcgc tagtaatcgc gaatcagaat 1140
gtcgcggtga atacgttccc gggtcttgta cacaccgccc gtcacaccat gggagtcagt 1200
aacgcccgaa gccggtacct aaggagccgt cgaaggtggg accgataact ggggtgaagt 1260
cgtaacaagg ta 1272
<210> 177
<211> 1445
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_hylemonae
<400> 177
aggatgaacg ctgccgccgt gcttaacaca tgcaagtcga acgaagcaat actgtgtgaa 60
gagattagct tgctaagatc agaactttgt attgactgag tggcggacgg gtgagtaacg 120
cgtgggcaac ctgccttaca cagggggata acagctagaa atggctgcta ataccgcata 180
agacctcagt accgcatggt agaggggtaa aaactccggt ggtgtaagat gggcccgcgt 240
ctgattaggt agttggtagg gtaacggcct accaagccga cgatcagtag ccgacctgag 300
agggtgaccg gccacattgg actgagacac ggcccaaact cctacgggag gcagcagtgg 360
ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgaagg atgaagtatt 420
tcggtatgta aacttctatc agcagggaag aagatgacgg tacctgacta agaagccccg 480
gctaactacg tgccagcagc cgcggtaata cgtagggggc aagcgttatc cggatttact 540
gggtgtaaag ggagcgtaga cggcatggca agtctgaagt gaaagcccgg ggctcaaccc 600
cgggactgct ttggaaactg tcaggctaga gtgtcggaga ggcaagtgga attcctagtg 660
tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaagcggct tgctggacga 720
tgactgacgt tgaggctcga aagcgtgggg agcaaacagg attagatacc ctggtagtcc 780
acgccgtaaa cgatgattac taggtgtcgg gaagcaaagc ttttcggtgc cgcagccaac 840
gcaataagta atccacctgg ggagtacgtt cgcaagaatg aaactcaaag gaattgacgg 900
ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag aaccttacct 960
gatcttgaca tcccggtgac aaagtatgta acgtactctt tcttcggaac accggtgaca 1020
ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacggc 1080
gcaaccctta tctttagtag ccagcatttg aggtgggcac tctagagaga ctgccaggga 1140
taacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgac cagggctaca 1200
cacgtgctac aatggcgtaa acaaagggaa gcgaccctgt gaaggcaagc aaatcccaaa 1260
aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg gaatcgctag 1320
taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac accgcccgtc 1380
acaccatggg gtcagtaacg cccgaagccg gtgacctaac cgcaaaggag gagccgtcga 1440
aggtg 1445
<210> 178
<211> 1298
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_hylemonae
<400> 178
ctttgtattg actgagtggc ggacgggtga gtaacgcgtg ggcaacctgc cttacacagg 60
gggataacag ctagaaatgg ctgctaatac cgcataagac ctcagtaccg catggtagag 120
gggtaaaaac tccggtggtg taagatgggc ccgcgtctga ttaggtagtt ggtagggtaa 180
cggcctacca agccgacgat cagtagccga cctgagaggg tgaccggcca cattggactg 240
agaaacggcc caaactccta cgggaggcag cagtggggaa tattgcacaa tgggggaaac 300
cctgatgcag cgacgccgcg tgaaggatga agtatttcgg tatgtaaact tctatcagca 360
gggaagaaga tgacggtacc tgactaagaa gccccggcta actacgtgcc agcagccgcg 420
gtaatacgta gggggcaagc gttatccgga tttactgggt gtaaagggag cgtagacggc 480
atggcaagtc tgaagtgaaa gcccggggct caaccccggg actgctttgg aaactgtcag 540
gctagagtgt cggagaggca agtggaattc ctagtgtagc ggtgaaatgc gtagatatta 600
ggaggaacac cagtggcgaa ggcggcttgc tggacgatga ctgacgttga ggctcgaaac 660
cgtggggagc aaacaggatt agataccctg gtagtccacg ccgtaaacga tgattactag 720
gtgtcgggaa gcaaagcttt tcggtgccgc agccaacgca ataagtaatc cacctgggga 780
gtacgttcgc aagaatgaaa ctcaaaggaa ttgacgggga cccgcacaag cggtggagca 840
tgtggtttaa ttcgaagcaa cgcgaagaac cttacctgat cttgacatcc cggtgacaaa 900
gtatgtaacg tactctttct tcggaacacc ggtgacaggt ggtgcatggt tgtcgtcagc 960
tcgtgtcgtg agatgttggg ttaagtcccg caacgggcgc aacccttatc tttagtagcc 1020
agcatttgag gtgggcactc tagagagact gccagggata acctggagga aggtggggat 1080
gacgtcaaat catcatgccc cttatgacca gggctacaca cgtgctacaa tggcgtaaac 1140
aaagggaagc gaccctgtga aggcaagcaa atcccaaaaa taacgtctca gttcggattg 1200
tagtctgcaa ctcgactaca tgaagctgga atcgctagta atcgcgaatc agaatgtcgc 1260
ggtgaatacg gttcccgggt cttgtacaca ccgcccgt 1298
<210> 179
<211> 1475
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_innocuum
<220>
<221> misc_feature
<222> (905)..(905)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (942)..(942)
<223> n is a, c, g, or t
<400> 179
atggagagtt tgatcctggc tcaggatgaa cgctggcggc atgcctaata catgcaagtc 60
gaacgaagtc ttcaggaagc ttgcttccaa aaagacttag tggcgaacgg gtgagtaaca 120
cgtaggtaac ctgcccatgt gtccgggata actgctggaa acggtagcta aaaccggata 180
ggtatacgga gcgcatgctc tgtatattaa agcgcccttc aaggcgtgaa catggatgga 240
cctgcgacgc attagctagt tggtgaggta acggcccacc aaggcgatga tgcgtagccg 300
gcctgagagg gtaaacggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtaggg aattttcgtc aatgggggaa accctgaacg agcaatgccg cgtgagtgaa 420
gaaggtcttc ggatcgtaaa gctctgttgt aagtgaagaa cggctcatag aggaaatgct 480
atgggagtga cggtagctta ccagaaagcc acggctaact acgtgccagy agccgcggta 540
atacgtaggt ggcaagcgtt atccggaatc attgggcgta aagggtgcgt aggtggcgta 600
ctaagtctgt agtaaaaggc aatggctcaa ccattgtaag ctatggaaac tggtatgctg 660
gagtgcagaa gagggcgatg gaattccatg tgtagcggta aaatgcgtag atatatggag 720
gaacaccagt ggcgaaggcg gtcgcctggt ctgtaactga cactgaggca cgaaagcgtg 780
gggagcaaat aggattagat accctagtag tccacgccgt aaacgatgag aactaagtgt 840
tggagaaatt cagtgctgca gttaacgcaa taagttctcc gcctggggag tatgcacgca 900
agttngaaac tcaaaggaat tgacgggggc ccgcacaagc gntggagtat gtggtttaat 960
tcgaagcaac gcgaagaacc ttaccaggcc ttgacatgga aacaaatacc ctagagatag 1020
ggggataatt atggatcaca caggtggtgc atggttgtcg tcagctcgtg tcgtgagatg 1080
ttgggttaag tcccgcaacg agcgcaaccc ttgtcgcatg ttaccagcat caagttgggg 1140
actcatgcga gactgccggt gacaaaccgg aggaaggtgg ggatgacgtc aaatcatcat 1200
gccccttatg gcctgggcta cacacgtact acaatggcga ccacaaagag cagcgacttg 1260
gtgacaagaa gcgaatctca taaagatcgt ctcagttcgg attgaagtct gcaactcgac 1320
ttcatgaagt cggaatcgct agtaatcgca gatcagcatg ctgcggtgaa tacgttctcg 1380
ggccttgtac acaccgcccg tcaaaccatg ggagtcagta atacccgaag ccggtggcat 1440
aaccgtaagg agtgagccgt cgaaggtagg accga 1475
<210> 180
<211> 1480
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_innocuum
<220>
<221> misc_feature
<222> (1)..(1)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (4)..(5)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (910)..(910)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (947)..(947)
<223> n is a, c, g, or t
<400> 180
ncannatgga gagtttgatc ctggctcagg atgaacgctg gcggcatgcc taatacatgc 60
aagtcgaacg aagtcttcag gaagcttgct tccaaaaaga cttagtggcg aacgggtgag 120
taacacgtag gtaacctgcc catgtgtccg ggataactgc tggaaacggt agctaaaacc 180
ggataggtat acggagcgca tgctctgtat attaaagcgc ccttcaaggc gtgaacatgg 240
atggacctgc gacgcattag ctagttggtg aggtaacggc ccaccaaggc gatgatgcgt 300
agccggcctg agagggtaaa cggccacatt gggactgaga cacggcccaa actcctacgg 360
gaggcagcag tagggaattt tcgtcaatgg gggaaaccct gaacgagcaa tgccgcgtga 420
gtgaagaagg tcttcggatc gtaaagctct gttgtaagtg aagaacggct catagaggaa 480
atgctatggg agtgacggta gcttaccaga aagccacggc taactacgtg ccagyagccg 540
cggtaatacg taggtggcaa gcgttatccg gaatcattgg gcgtaaaggg tgcgtaggtg 600
gcgtactaag tctgtagtaa aaggcaatgg ctcaaccatt gtaagctatg gaaactggta 660
tgctggagtg cagaagaggg cgatggaatt ccatgtgtag cggtaaaatg cgtagatata 720
tggaggaaca ccagtggcga aggcggtcgc ctggtctgta actgacactg aggcacgaaa 780
gcgtggggag caaataggat tagataccct agtagtccac gccgtaaacg atgagaacta 840
agtgttggag aaattcagtg ctgcagttaa cgcaataagt tctccgcctg gggagtatgc 900
acgcaagttn gaaactcaaa ggaattgacg ggggcccgca caagcgntgg agtatgtggt 960
ttaattcgaa gcaacgcgaa gaaccttacc aggccttgac atggaaacaa ataccctaga 1020
gataggggga taattatgga tcacacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg 1080
agatgttggg ttaagtcccg caacgagcgc aacccttgtc gcatgttacc agcatcaagt 1140
tggggactca tgcgagactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc 1200
atcatgcccc ttatggcctg ggctacacac gtactacaat ggcgaccaca aagagcagcg 1260
acttggtgac aagaagcgaa tctcataaag atcgtctcag ttcggattga agtctgcaac 1320
tcgacttcat gaagtcggaa tcgctagtaa tcgcagatca gcatgctgcg gtgaatacgt 1380
tctcgggcct tgtacacacc gcccgtcaaa ccatgggagt cagtaatacc cgaagccggt 1440
ggcataaccg taaggagtga gccgtcgaag gtaggaccga 1480
<210> 181
<211> 1475
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_innocuum
<400> 181
ctggctcagg atgaacgctg gcggcatgcc taatacatgc aagtcgaacg aagtttcgag 60
gaagcttgct tccaaagaga cttagtggcg aacgggtgag taacacgtag gtaacctgcc 120
catgtgtccg ggataactgc tggaaacggt agctaaaacc ggataggtat acagagcgca 180
tgctcagtat attaaagcgc ccatcaaggc gtgaacatgg atggacctgc ggcgcattag 240
ctagttggtg aggtaacggc ccaccaaggc gatgatgcgt agccggcctg agagggtaaa 300
cggccacatt gggactgaga cacggcccaa actcctacgg gaggcagcag tagggaattt 360
tcgtcaatgg gggaaaccct gaacgagcaa tgccgcgtga gtgaagaagg tcttcggatc 420
gtaaagctct gttgtaagtg aagaacggct catagaggaa atgctatggg agtgacggta 480
gcttaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg taggtggcaa 540
gcgttatccg gaatcattgg gcgtaaaggg tgcgtaggtg gcgtactaag tctgtagtaa 600
aaggcaatgg ctcaaccatt gtaagctatg gaaactggta tgctggagtg cagaagaggg 660
cgatggaatt ccatgtgtag cggtaaaatg cgtagatata tggaggaaca ccagtggcga 720
aggcggtcgc ctggtctgta actgacactg aggcacgaaa gcgtggggag caaataggat 780
tagataccct agtagtccac gccgtaaacg atgagaacta agtgttggag gaattcagtg 840
ctgcagttaa cgcaataagt tctccgcctg gggagtatgc acgcaagtgt gaaactcaaa 900
ggaattgacg ggggcccgca caagcggtgg agtatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc aggccttgac atggaaacaa ataccctaga gataggggga taattatgga 1020
tcacacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aacccttgtc gcatgttacc agcatcaagt tggggactca tgcgagactg 1140
ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc ttatggcctg 1200
ggctacacac gtactacaat ggcgrccaca aagagcagcg acacagtgat gtgaagcgaa 1260
tctcataaag gtcgtctcag ttcggattga agtctgcaac tcgacttcat gaagtcggaa 1320
tcgctagtaa tcgcagatca gcatgctgcg gtgaatacgt tctcgggcct tgtacacacc 1380
gcccgtcaaa ccatgggagt cagtaatacc cgaagccggt ggcataaccg taaggagtga 1440
gccgtcgaag gtaggaccga tgactggggt taagt 1475
<210> 182
<211> 1444
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_innocuum
<400> 182
agacttagtg gcgaacgggt gagtaacacg taggtaacct gcccatgtgt ccgggataac 60
tgctggaaac ggtagctaaa accggatagg tatacggagc gcatgctctg tatattaaag 120
cgcccatcaa ggcgtgaaca tggatggacc tgcggcgcat tagctagttg gtgaggtaac 180
ggcccaccaa ggcgatgatg cgtagccggc ctgagagggt aaacggccac attgggactg 240
agacacggcc caaactccta cgggaggcag cagtagggaa ttttcgtcaa tgggggaaac 300
cctgaacgag caatgccgcg tgagtgaaga aggtcttcgg atcgtaaagc tctgttgtaa 360
gtgaagaacg gctcatagag gaaatgctat gggagtgacg gtagcttacc agaaagccac 420
ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttat ccggaatcat 480
tgggcgtaaa gggtgcgtag gtggcgtact aagtctgtag taaaaggcaa tggctcaacc 540
attgtaagct atggaaactg gtatgctgga gtgcagaaga gggcgatgga attccatgtg 600
tagcggtaaa atgcgtagat atatggagga acaccagtgg cgaaggcggt cgcctggtct 660
gtaactgaca ctgaggcacg aaagcgtggg gagcaaatag gattagatac cctagtagtc 720
cacgccgtaa acgatgagaa ctaagtgttg gaggaattca gtgctgcagt taacgcaata 780
agttctccgc ctggggagta tgcacgcaag tgtgaaactc aaaggaattg acgggggccc 840
gcacaagcgg tggagtatgt ggtttaattc gaagcaacgc gaagaacctt accaggcctt 900
gacatggaaa caaataccct agagataggg ggataattat ggatcacaca ggtggtgcat 960
ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt 1020
gtcgcatgtt accagcatca agttggggac tcatgcgaga ctgccggtga caaaccggag 1080
gaaggtgggg atgacgtcaa atcatcatgc cccttatggc ctgggctaca cacgtactac 1140
aatggcgacc acaaagagca gcgacacagt gatgtgaagc gaatctcata aaggtcgtct 1200
cagttcggat tgaagtctgc aactcgactt catgaagtcg gaatcgctag taatcgcaga 1260
tcagcatgct gcggtgaata cgttctcggg ccttgtacac accgcccgtc aaaccatggg 1320
agtcagtaat acccgaagcc ggtggcataa ccgtaaggag tgagccgtcg aaggtaggac 1380
cgatgactgg ggttaagtcg taacaaggta tccctacggg aacgtgggga tggatcacct 1440
cctt 1444
<210> 183
<211> 1489
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_irregulare
<400> 183
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaacacat gcaagtcgag 60
cgaacttcgg ggtgagcggc ggacgggtga gtaacgcgtg ggtaacctgc ctcatacaca 120
tgggataaca taccgaaagg tatgctaata caggataaca tagtttttat cgcatgataa 180
aaatatcaaa gctccggcgg tatgagatgg acccgcgtct gattagctag ttggtaaggt 240
aatggcttac caaggcgacg atcagtagcc gacctgagag ggtgatcggc cacattggaa 300
ctgagacacg gtccaaactc ctacgggagg cagcagtggg gaatattgca caatgggcga 360
aagcctgatg cagcaacgcc gcgtgagcga tgaaggcctt cgggtcgtaa agctctgtcc 420
tcaaggaaga taatgacggt acttgaggag gaagccccgg ctaactacgt gccagcagcc 480
gcggtaatac gtagggggct agcgttatcc ggatttactg ggcgtaaagg gtgcgtaggc 540
ggtctttcaa gtcaggagtg aaaggctacg gctcaaccgt agtaagctct tgaaactggg 600
agacttgagt gcaggagagg agagtggaat tcctagtgta gcggtgaaat gcgtagatat 660
taggaggaac accagtagcg aaggcgctct ctggactgta actgacgctg aggcacgaaa 720
gcgtggggag cgaacaggat tagataccct ggtagtccac gccgtaaacg atgagtacta 780
ggtgtcgggg gttaccccct cggtgccgca gctaacgcat taagtactcc gcctggggag 840
tacgctcgca agagtgaaac tcaaaggaat tgacggggac ccgcacaagt agcggagcat 900
gtggtttaat tcgaagcaac gcgaagaacc ttacctaagc ttgacatcct tctgactctc 960
cttaatcgga gatttccttc ggggacagaa gtgacaggtg gtgcatggtt gtcgtcagct 1020
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccttgcct ttagttgcca 1080
gcattaagtt gggcactcta gagggactgc cagggtaacc tggaggaagg tggggatgac 1140
gtcaaatcat catgcccctt atgcttaggg ctacacacgt gctacaatgg gtggtacaga 1200
gggcagccaa gtcgtgaggc ggagctaatc ccttaaagcc attctcagtt cggattgtag 1260
gctgaaactc gcctacatga agctggagtt actagtaatc gcagatcaga atgctgcggt 1320
gaatgcgttc ccgggtcttg tacacaccgc ccgtcacacc acgggagttg gagacgcccg 1380
aagcggacta tctaaccttt tggaagaagt cgtcgaaggt ggaatcaata actggggtga 1440
agtcgtaaca aggtagccgt aggagaacct gcggctggat cacctcctt 1489
<210> 184
<211> 1454
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_lavalense
<400> 184
gatgaacgct ggcggcgtgc ctaacacatg caagtcgaac gaagcatttt raatgaagtt 60
ttcggatgga ttytgagatg actgagtggc ggacgggtga gtaacacgtg gataacctgc 120
ctcacactgg gggacaacag ttagaaatga ctgctaatac cgcataagcg cacagtaccg 180
catggtacag tgtgaaaaac tccggtggtg tgagatggat ccgcgtctga ttagccagtt 240
ggcggggtaa cggcccacca aagcgacgat cagtagccga cctgagaggg tgaccggcca 300
cattgggact gagacacggc ccaaactcct acgggaggca gcagtgggga atattgcaca 360
atgggcgaaa gcctgatgca gcgacgccgc gtgagtgaag aagtatttcg gtatgtaaag 420
ctctatcagc agggaagata atgacggtac ctgactaaga agccccggct aactacgtgc 480
cagcagccgc ggtaatacgt agggggcaag cgttatccgg atttactggg tgtaaaggga 540
gcgtagacgg catggcaagt ctgaagtgaa aacccagggc tcaaccctgg gactgctttg 600
gaaactgtca agctagagtg caggagaggt aagtggaatt cctagtgtag cggtgaaatg 660
cgtagatatt aggaggaaca ccagtggcga aggcggctta ctggactgta actgacgttg 720
aggctcgaaa gcgtggggag caaacaggat tagataccct ggtagtccac gccgtaaacg 780
atgagtgcta ggtgttgggg ggcaaagccc ttcggtgccg tcgcaaacgc aataagcact 840
ccacctgggg agtacgttcg caagaatgaa actcaaagga attgacgggg acccgcacaa 900
gcggtggagc atgtggttta attcgaagca acgcgaagaa ccttaccaag tcttgacatc 960
ctcttgaccg gcgtgtaacg gcgcctttcc ttcgggacaa grgagacagg tggtgcatgg 1020
ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg caacccttat 1080
ccttagtagc cagcartrag atgggcactc tagggagact gccagggaca acctggagga 1140
aggtggggat gacgtcaaat catcatgccc cttatgattt gggctacaca cgtgctacaa 1200
tggcgtaaac aaagggaagc gaccctgcga aggtgagcaa atctcaaaaa taacgtccca 1260
gttcggactg tagtctgcaa cccgactaca cgaagctgga atcgctagta atcgcgaatc 1320
agaatgtcgc ggtgaatacg ttcccgggtc ttgtacacac cgcccgtcac accatgggag 1380
tcagcaacgc ccgaagtcag tgacccaact cgcargagag ggakctgccg aasgcggcgc 1440
akgtaactgg ggtg 1454
<210> 185
<211> 1494
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_mayombei
<400> 185
gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc aagtcgagcg 60
attctcttcg gagaagagcg gcggacgggt gagtaacgcg tgggtaacct gcctcataca 120
catggataac ataccgaaag gtatgctaat acaggatgat ataagagatt cacatggatt 180
tcttatcaaa gctccggcgg tatgagatgg acccgcgtct gattagctag ttggtaaggt 240
aatggcttac caaggcgacg atcagtagcc gacctgagag ggtgatcggc cacattggaa 300
ctgagacacg gtccaaactc ctacgggagg cagcagtggg gaatattgca caatgggcga 360
aagcctgatg cagcaacgcc gcgtgagtga tgaaggcctt cgggtcgtaa aactctgtcc 420
tcaaggaaga taatgacggt acttgaggag gaagccccgg ctaactacgt gccagcagcc 480
gcggtaatac gtagggggct agcgttatcc ggatttactg ggcgtaaagg gtgcgtaggt 540
ggtttcttaa gtcaggagtg aaaggctacg gctcaaccgt agtaagctct tgaaactggg 600
agacttgagt gcaggagagg aaagtggaat tcctagtgta gcggtgaaat gcgtagatat 660
taggaggaac accagtagcg aaggcggctt tctggactgt aactgacact gaggcacgaa 720
agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtact 780
aggtgtcggg ggttaccccc ctcggtgccg cagctaacgc attaagtact ccgcctgggg 840
agtacgctcg caagagtgaa actcaaagga attgacgggg acccgcacaa gtagcggagc 900
atgtggttta attcgaagca acgcgaagaa ccttacctaa gcttgacatc cttttgaccg 960
atgcctaatc gcatctttcc cttcggggac agaagtgaca ggtggtgcat ggttgtcgtc 1020
agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gcctttagtt 1080
gccagcatta agttgggcac tctagaggga ctgccaggga taacctggag gaaggtgggg 1140
atgacgtcaa atcatcatgc cccttatgct tagggctaca cacgtgctac aatgggtggt 1200
acagagggca gccaagtcgt gaggccgagc taatccctta aagccattct cagttcggat 1260
tgtaggctga aactcgccta catgaagctg gagttactag taatcgcaga tcagaatgct 1320
gcggtgaatg cgttcccggg tcttgtacac accgcccgtc acaccacgga agttgggggc 1380
gcccgaagcc acttagctaa ccttttggaa gcgagtgtcg aaggtgaaat caataactgg 1440
ggtgaagtcg taacaaggta gccgtatcgg aaggtgcggc tggatcacct cctt 1494
<210> 186
<211> 1500
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_orbiscindens
<400> 186
ggctcaggat gaacgctggc ggcgtgctta acacatgcaa gtcgaacggg gtgctcatga 60
cggaggattc gtccaacgga ttgagttacc tagtggcgga cgggtgagta acgcgtgagg 120
aacctgcctt ggagagggga ataacactcc gaaaggagtg ctaataccgc atgatgcagt 180
tgggtcgcat ggctctgact gccaaagatt tatcgctctg agatggcctc gcgtctgatt 240
agctagtagg cggggtaacg gcccacctag gcgacgatca gtagccggac tgagaggttg 300
accggccaca ttgggactga gacacggccc agactcctac gggaggcagc agtggggaat 360
attgggcaat gggcgcaagc ctgacccagc aacgccgcgt gaaggaagaa ggctttcggg 420
ttgtaaactt cttttgtcgg ggacgaaaca aatgacggta cccgacgaat aagccacggc 480
taactacgtg ccagcagccg cggtaatacg taggtggcaa gcgttatccg gatttactgg 540
gtgtaaaggg cgtgtaggcg ggattgcaag tcagatgtga aaactggggg ctcaacctcc 600
agcctgcatt tgaaactgta gttcttgagt gctggagagg caatcggaat tccgtgtgta 660
gcggtgaaat gcgtagatat acggaggaac accagtggcg aaggcggatt gctggacagt 720
aactgacgct gaggcgcgaa agcgtgggga gcaaacagga ttagataccc tggtagtcca 780
cgccgtaaac gatggatact aggtgtgggg ggtctgaccc cctccgtgcc gcagttaaca 840
caataagtat cccacctggg gagtacgatc gcaaggttga aactcaaagg aattgacggg 900
ggcccgcaca agcggtggag tatgtggttt aattcgaagc aacgcgaaga accttaccag 960
ggcttgacat cccactaacg aagcagagat gcattaggtg cccttcgggg aaagtggaga 1020
caggtggtgc atggttgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1080
agcgcaaccc ttattgttag ttgctacgca agagcactct agcgagactg ccgttgacaa 1140
aacggaggaa ggtggggacg acgtcaaatc atcatgcccc ttatgtcctg ggccacacac 1200
gtactacaat ggtggttaac agagggaggc aataccgcga ggtggagcaa atccctaaaa 1260
gccatcccag ttcggattgc aggctgaaac ccgcctgtat gaagttggaa tcgctagtaa 1320
tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca 1380
ccatgagagt cgggaacacc cgaagtccgt agcctaaccg caaggagggc gcggccgaag 1440
gtgggttcga taattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg 1500
<210> 187
<211> 1526
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_oroticum
<400> 187
gtttgatcct ggctcaggat gaacgctggc ggcgtgctta acacatgcaa gtcgagcgaa 60
gcacaatact caagatttct tcggattgaa gagtgttgcg actgagcggc ggacgggtga 120
gtaacgcgtg ggtaacctgc ctcatacagg gggataacag ttagaaatga ctgctaatac 180
cgtataagac cacagtgccg catggcacag tggtaaaaac tccggtggta tgagatggac 240
ccgcgtctga ttagctagtt ggtaaggtaa cggcttacca aggcgacgat cagtagccga 300
cctgagaggg tgaccggcca cattgggact gagacacggc ccaaactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgacgca gcgacgccgc gtgaaggatg 420
aagtatttcg gtatgtaaac ttctatcagc agggaagaaa atgacggtac ctgactaaga 480
agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggcaag cgttatccgg 540
atttactggg tgtaaaggga gcgtagacgg tgatgcaagt ctgatgtgaa aacccggggc 600
tcaaccccgg gactgcattg gaaactgtgt gactagagtg tcggagaggt aagtggaatt 660
cctagtgtag cggtgaaatg cgtagatatt aggaggaaca ccagtggcga aggcggctta 720
ctggacgatg actgacgttg aggctcgaaa gcgtggggag caaacaggat tagataccct 780
ggtagtccac gccgtaaacg atgaatacta ggtgtcgggt ggcaaagcca ttcggtgccg 840
cagcaaacgc agtaagtatt ccacctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 960
ccttacctgc tcttgacatc ccgctgaccg gccagtaatg tggccttccc ttcggggcag 1020
tggagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccttat ctttagtagc cagcggcttg gccgggcact ctagagagac 1140
tgccagggat aacctggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgagc 1200
agggctacac acgtgctaca atggcgtaaa caaagggagg caatactgtg aagtggagca 1260
aatcccaaaa ataacgtctc agttcggatt gtagtctgca actcgactac atgaagctgg 1320
aatcgctagt aatcgcgaat cagaatgtcg cggtgaatac gttcccgggt cttgtacaca 1380
ccgcccgtca caccatggga gttggtaacg cccgaagtca gtgacccaac cgcaaggagg 1440
gagctgccga aggtgggacc gataactggg gtgaagtcgt aacaaggtag ccgtatcgga 1500
aggtgcggct ggatcacctc ctttct 1526
<210> 188
<211> 1476
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_paraputrificum
<400> 188
agagtttgat cctggctcag gacgaacgct ggcggcgtgc ctaacacatg caagtcgagc 60
gatgaagttc cttcgggaac ggattagcgg cggacgggtg agtaacacgt gggcaacctg 120
ccttatagag gggaatagcc ttccgaaagg aagattaata ccgcataaga ttgtagcttc 180
gcatgaagta gcaattaaag gagcaatccg ctataagatg ggcccgcggc gcattagcta 240
gttggtgagg taacggctca ccaaggcgac gatgcgtagc cgacctgaga gggtgatcgg 300
ccacattggg actgagacac ggcccagact cctacgggag gcagcagtgg ggaatattgc 360
acaatggggg aaaccctgat gcagcaacgc cgcgtgagtg atgacggcct tcgggttgta 420
aagctctgtc tttggggacg ataatgacgg tacccaagga ggaagccacg gctaactacg 480
tgccagcagc cgcggtaata cgtaggtggc aagcgttgtc cggatttact gggcgtaaag 540
ggagcgtagg cggattttta agtgggatgt gaaatacccg ggctcaacct gggtgctgca 600
ttccaaactg gaaatctaga gtgcaggagg ggaaagtgga attcctagtg tagcggtgaa 660
atgcgtagag attaggaaga acaccagtgg cgaaggcgac tttctggact gtaactgacg 720
ctgaggctcg aaagcgtggg gagcaaacag gattagatac cctggtagtc cacgccgtaa 780
acgatgaata ctaggtgtag gggttgtcat gacctctgtg ccgccgctaa cgcattaagt 840
attccgcctg gggagtacgg tcgcaagatt aaaactcaaa ggaattgacg ggggcccgca 900
caagtagcgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc tagacttgac 960
atctcctgaa ttaccatgta atgtgggaag tcctttcggg gacaggaaga caggtggtgc 1020
atggttgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc 1080
ttattgttag ttgctaccat ttagttgagc actctagcga gactgcccgg gttaaccggg 1140
aggaaggtgg ggatgacgtc aaatcatcat gccccttatg tctagggcta cacacgtgct 1200
acaatggccg gtacaacgag atgcaatacc gtgaggtgga gcaaaactat aaaaccggtc 1260
tcagttcgga ttgtaggctg aaactcgcct acatgaagct ggagttacta gtaatcgcga 1320
atcagaatgt cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1380
gagttggcaa tacccaaagt tggtgatcta acccgtaagg gaggaagcca cctaaggtag 1440
ggtcagcgat tggggtgaag tcgtaacaag gtaacc 1476
<210> 189
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_scindens
<400> 189
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaacacat gcaagtcgaa 60
cgaagcgcct ggccccgact tcttcggaac gaggagcctt gcgactgagt ggcggacggg 120
tgagtaacgc gtgggcaacc tgccttgcac tgggggataa cagccagaaa tggctgctaa 180
taccgcataa gaccgaagcg ccgcatggcg cggcggccaa agccccggcg gtgcaagatg 240
ggcccgcgtc tgattaggta gttggcgggg taacggccca ccaagccgac gatcagtagc 300
cgacctgaga gggtgaccgg ccacattggg actgagacac ggcccagact cctacgggag 360
gcagcagtgg ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgaagg 420
atgaagtatt tcggtatgta aacttctatc agcagggaag aagatgacgg tacctgacta 480
agaagccccg gctaactacg tgccagcagc cgcggtaata cgtagggggc aagcgttatc 540
cggatttact gggtgtaaag ggagcgtaga cggcgatgca agccagatgt gaaagcccgg 600
ggctcaaccc cgggactgca tttggaactg cgtggctgga gtgtcggaga ggcaggcgga 660
attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaaggcggc 720
ctgctggacg atgactgacg ttgaggctcg aaagcgtggg gagcaaacag gattagatac 780
cctggtagtc cacgccgtaa acgatgacta ctaggtgtcg ggtggcaagg ccattcggtg 840
ccgcagcaaa cgcaataagt agtccacctg gggagtacgt tcgcaagaat gaaactcaaa 900
ggaattgacg gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc tgatcttgac atcccgatgc caaagcgcgt aacgcgctct ttcttcggaa 1020
catcggtgac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaacccc tatcttcagt agccagcatt ttggatgggc actctggaga 1140
gactgccagg gagaacctgg aggaaggtgg ggatgacgtc aaatcatcat gccccttatg 1200
accagggcta cacacgtgct acaatggcgt aaacaaaggg aggcgaaccc gcgagggtgg 1260
gcaaatccca aaaataacgt ctcagttcgg attgtagtct gcaactcgac tacatgaagt 1320
tggaatcgct agtaatcgcg aatcagaatg tcgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagtcagta acgcccgaag ccggtgaccc aacccgtaag 1440
ggagggagcc gtcgaaggtg ggaccgataa ctggggtgaa gtcgtaacaa ggtagccgta 1500
tcggaaggtg cggctggatc acctccttc 1529
<210> 190
<211> 1405
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sordellii
<400> 190
ggcggcgtgc ctaacacatg caagtcgagc gatctcttcg gagagagcgg cggacgggtg 60
agtaacgcgt gggtaacctg ccctgtacac acggataaca taccgaaagg tatactaata 120
cgggataaca tatgaaagtc gcatggcttt tgtatcaaag ctccggcggt acaggatgga 180
cccgcgtctg attagctagt tggtaaggta atggcttacc aaggcaacga tcagtagccg 240
acctgagagg gtgatcggcc acactggaac tgagacacgg tccagactcc tacgggaggc 300
agcagtgggg aatattgcac aatgggcgaa agcctgatgc agcaacgccg cgtgagcgat 360
gaaggccttc gggtcgtaaa gctctgtcct caaggaagat aatgacggta cttgaggagg 420
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcta gcgttatccg 480
gaattactgg gcgtaaaggg tgcgtaggtg gttttttaag tcagaagtga aaggctacgg 540
ctcaaccgta gtaagctttt gaaactagag aacttgagtg caggagagga gagtagaatt 600
cctagtgtag cggtgaaatg cgtagatatt aggaggaata ccagtagcga aggcggctct 660
ctggactgta actgacactg aggcacgaaa gcgtggggag caaacaggat tagataccct 720
ggtagtccac gccgtaaacg atgagtacta ggtgtcgggg gttacccccc tcggtgccgc 780
agctaacgca ttaagtactc cgcctgggaa gtacgctcgc aagagtgaaa ctcaaaggaa 840
ttgacgggga cccgcacaag tagcggagca tgtggtttaa ttcgaagcaa cgcgaagaac 900
cttacctaag cttgacatcc cactgacctc tccctaatcg gagatttccc ttcggggaca 960
gtggtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1020
cgcaacgagc gcaacccttg cctttagttg ccagcattaa gttgggcact ctagagggac 1080
tgccgaggat aactcggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgctt 1140
agggctacac acgtgctaca atgggtggta cagagggttg ccaagccgcg aggtggagct 1200
aatcccttaa agccattctc agttcggatt gtaggctgaa actcgcctac atgaagctgg 1260
agttactagt aatcgcagat cagaatgctg cggtgaatgc gttcccgggt cttgtacaca 1320
ccgcccgtca caccatggaa gttgggggcg cccgaagccg gttagctaac cttttaggaa 1380
gcggccgtcg agagctaaac cagta 1405
<210> 191
<211> 1515
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sp_7_2_43FAA
<400> 191
attgagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaaca catgcaagtc 60
gagcgagagg agttccttcg ggaacaaatc tagcggcgga cgggtgagta acacgtgggc 120
aacctgcctt gtagagggga atagccttcc gaaaggaaga ttaataccgc ataacattac 180
attttcgcat gaagaagtaa ttaaaggagc aatccgctac aagatgggcc cgcggcgcat 240
tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 300
gatcggccac attgggactg agacacggcc cagactccta cgggaggcag cagtggggaa 360
tattgcacaa tgggggaaac cctgatgcag caacgccgcg tgagtgatga aggttttcgg 420
atcgtaaagc tctgtcttca gggacgataa tgacggtacc tgaggaggaa gccacggcta 480
actacgtgcc agcagccgcg gtaatacgta ggtggcgagc gttgtccgga tttactgggc 540
gtaaagggag cgtaggcgga tttttaagtg agatgtgaaa tacccgggct caacttgggt 600
gctgcatttc aaactggaag tctagagtgc aggagaggag agtggaattc ctagtgtagc 660
ggtgaaatgc gtagagatta ggaagaacac cagtggcgaa ggcgactctc tggactgtaa 720
ctgacgctga ggctcgaaag cgtggggagc aaacaggatt agataccctg gtagtccacg 780
ccgtaaacga tgaatactag gtgtaggggt tgtcatgacc tctgtgccgc cgcaaacgca 840
ttaagtattc cgcctgggga gtacggtcgc aagattaaaa ctcaaaggaa ttgacggggg 900
cccgcacaag cagcggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttacctaga 960
cttgacatct cctgcattac tcttaatcga ggaagtcctt tcggggacag gatgacaggt 1020
ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc 1080
aacccttatt gttagttgct accatttagt tgagcactct agcgagactg cccgggttaa 1140
ccgggaggaa ggtggggatg acgtcaaatc atcatgcccc ttatgtctag ggctacacac 1200
gtgctacaat ggcaagtaca aagagatgcg ataccgcgag gtggagctaa actataaaac 1260
ttgtctcagt tcggattgta ggctgaaact cgcctacatg aagctggagt tgctagtaat 1320
cgcgaatcag aatgtcgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac 1380
catgagagtt ggcaataccc aaagttcgtg agctaacccg taagggaggc agcgacctaa 1440
ggtagggtca gcgattgggg tgaagtcgta acaaggtagc cgtaggagaa cctgcggctg 1500
gatcacctcc tttct 1515
<210> 192
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sp_D5
<400> 192
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgag 60
cgaagcgctt tacttagatt tcttcggatt gaagagtttt gcgactgagc ggcggacggg 120
tgagtaacgc gtgggtaacc tgcctcatac agggggataa cagttagaaa tgactgctaa 180
taccgcataa gaccacggta ccgcatggta cagtgggaaa aactccggtg gtatgagatg 240
gacccgcgtc tgattagcta gttggtaagg taacggctta ccaaggcgac gatcagtagc 300
cgacctgaga gggtgaccgg ccacattggg actgagacac ggcccaaact cctacgggag 360
gcagcagtgg ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgaagg 420
atgaagtatt tcggtatgta aacttctatc agcagggaag aaaatgacgg tacctgacta 480
agaagccccg gctaactacg tgccagcagc cgcggtaata cgtagggggc aagcgttatc 540
cggatttact gggtgtaaag ggagcgtaga cggttatgta agtctgatgt gaaaacccgg 600
ggctcaaccc cgggactgca ttggaaacta tgtaactaga gtgtcggaga ggtaagtgga 660
attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaaggcggc 720
ttactggacg atcactgacg ttgaggctcg aaagcgtggg gagcaaacag gattagatac 780
cctggtagtc cacgccgtaa acgatgaata ctaggtgtcg ggtggcaaag ccattcggtg 840
ccgcagcaaa cgcaataagt attccacctg gggagtacgt tcgcaagaat gaaactcaaa 900
ggaattgacg gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc tgctcttgac atcccactga ccggcgtgta atggcgcctt cccttcgggg 1020
cagtggagac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct tatctttagt agccagcggt ttggccgggc actctagaga 1140
gactgccagg gataacctgg aggaaggtgg ggatgacgtc aaatcatcat gccccttatg 1200
agcagggcta cacacgtgct acaatggcgt aaacaaaggg aggcaatacc gcgaggttga 1260
gcaaatccca aaaataacgt ctcagttcgg attgtagtct gcaactcgac tacatgaagc 1320
tggaatcgct agtaatcgcg aatcagaatg tcgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagttggta acgcccgaag tcagtgaccc aaccgtaagg 1440
agggagctgc cgaaggcggg atcgataact ggggtgaagt cgtaacaagg tagccgtatc 1500
ggaaggtgcg gctggatcac ctcctttct 1529
<210> 193
<211> 1543
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sp_HGF2
<400> 193
tcaaatggag agtttgatcc tggctcagga tgaacgctgg cggcatgcct aatacatgca 60
agtcgaacga agtttcgagg aagcttgctt ccaaagagac ttagtggcga acgggtgagt 120
aacacgtagg taacctgccc atgtgtccgg gataactgct ggaaacggta gctaaaaccg 180
gataggtata cagagcgcat gctcagtata ttaaagcgcc catcaaggcg tgaacatgga 240
tggacctgcg gcgcattagc tagttggtga ggtaacggcc caccaaggcg atgatgcgta 300
gccggcctga gagggtaaac ggccacattg ggactgagac acggcccaaa ctcctacggg 360
aggcagcagt agggaatttt cgtcaatggg ggaaaccctg aacgagcaat gccgcgtgag 420
tgaagaaggt cttcggatcg taaagctctg ttgtaagtga agaacggctc atagaggaaa 480
tgctatggga gtgacggtag cttaccagaa agccacggct aactacgtgc cagcagccgc 540
ggtaatacgt aggtggcaag cgttatccgg aatcattggg cgtaaagggt gcgtaggtgg 600
cgtactaagt ctgtagtaaa aggcaatggc tcaaccattg taagctatgg aaactggtat 660
gctggagtgc agaagagggc gatggaattc catgtgtagc ggtaaaatgc gtagatatat 720
ggaggaacac cagtggcgaa ggcggtcgcc tggtctgtaa ctgacactga ggcacgaaag 780
cgtggggagc aaataggatt agatacccta gtagtccacg ccgtaaacga tgagaactaa 840
gtgttggagg aattcagtgc tgcagttaac gcaataagtt ctccgcctgg ggagtatgca 900
cgcaagtgtg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gtatgtggtt 960
taattcgaag caacgcgaag aaccttacca ggccttgaca tggaaacaaa taccctagag 1020
atagggggat aattatggat cacacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga 1080
gatgttgggt taagtcccgc aacgagcgca acccttgtcg catgttacca gcatcaagtt 1140
ggggactcat gcgagactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca 1200
tcatgcccct tatggcctgg gctacacacg tactacaatg gcgaccacaa agagcagcga 1260
cttggtgaca agaagcgaat ctcataaagg tcgtctcagt tcggattgaa gtctgcaact 1320
cgacttcatg aagtcggaat cgctagtaat cgcagatcag catgctgcgg tgaatacgtt 1380
ctcgggcctt gtacacaccg cccgtcaaac catgggagtc agtaataccc gaagccggtg 1440
gcataaccgt aaggagtgag ccgtcgaagg taggaccgat gactggggtt aagtcgtaac 1500
aaggtatccc tacgggaacg tggggatgga tcacctcctt tct 1543
<210> 194
<211> 1512
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_spiroforme
<400> 194
gagagtttga tcctggctca ggatgaacgc tggcggctgc ctaatacatg caagtcgaac 60
gcgagcagca atgctcgagt ggcgaacggg tgagtaatac ataagtaacc tgccctagac 120
agggggataa ctgctggaaa ccagctaaga ccgcataggt atggacactg catggtgacc 180
atattaaaag tgccaaggca ctggtagagg atggacttat ggcgcattag ctggttggtg 240
aggtaacagc tcaccaaggc gacgatgcgt agccgacctg agagggtgac cggccacact 300
gggactgaga cacggcccag actcctacgg gaggcagcag tagggaattt tcggcaatgg 360
ggggaaccct gaccgagcaa cgccgcgtga aggaagaagg aattcgttct gtaaacttct 420
gttataaagg aagaacggcg gatataggga atgatatccg agtgacggta ctttatgaga 480
aagccacggc taactacgtg ccagcagccg cggtaatacg taggtggcga gcgttatccg 540
gaattattgg gcgtaaagag ggagcaggcg gcggcagagg tctgtggtga aagactgaag 600
cttabacttc agtaagccat agaaaccggg ctgctagagt gcaggagagg atcgtggaat 660
tcctgtgtag cggtgaaatg cgtagatata tggaggaaca ccagtggcga aggcgacggt 720
ctggcctgta actgacgctc attcccgaaa gcgtggggag caaataggat tagataccct 780
agtagtccac gccgtaaacg atgagtacta agtgttggga gtcaaatttc agtgctgcag 840
ttaacgcaat aagtactccg cctgagtagt acgttcgcaa gaatgaaact caaaggaatt 900
gacgggggcc gcacaagcgg tggagcatgt ggtttaattc gaagcaacgc gaagaacctt 960
accaggtctt gacatccgga taaagacctc agagatgagg ggatagatat atccgagaca 1020
ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag 1080
cgcaaccctt gtcgctagtt accatcatta agttggggac tctagcgaga ctgccagtga 1140
caagctggag gaaggcgggg atgacgtcaa atcatcatgc cccttatgac ctgggctaca 1200
cacgtgctac aatggatgga gcagagggaa gcgaagccgc gaggtgaagc aaaacccata 1260
aaaccattct cagttcggat tgtagtctgc aactcgacta catgaagttg gaatcgctag 1320
taatcgcgaa tcagcatgtc gcggtgaata cgttctcggg ccttgtacac accgcccgtc 1380
acaccatgag agttgataac acccgaagcc ggtggcctaa ccgcaaggag ggagctgtct 1440
aaggtgggat tgatgattgg ggtgaagtcg taacaaggta tccctacggg aacgtgcggc 1500
tggatcacct cc 1512
<210> 195
<211> 1364
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sp_MT4_E
<400> 195
catgcacgtc gagcgactct tctggagaga gcggcggacg ggagagcacg cgagggtacc 60
tgccctgtca cacggataac actaccgaaa ggtatactaa tacggggact aacatactga 120
aagtcgcatg gcttttgtat caaagctccg gcggtacagg atggacccgc gtctgattag 180
ctagttggta aggtaatggc ttaccaaggc aacgatcagt agccgacctt gagaagggtg 240
aatcgggcca ctactggaaa tgaagacacg ggtccaagac tcctactggg gaggcagcag 300
tggggaatat tgcacaatgg gcgaaagcct gatgcagcaa cgccgcgtga gcggatgaag 360
gccttcgggt cgtaaagctc tgtcctcaag gaagataatg acgggtactt tgaggaggaa 420
gccccgggct aactacgtgc cagcagccgc gggtaatacg gtagggggct agcgttatcc 480
gggaaattac tgggcgtaaa gggtgcggta aggtggtttt tttaagtcag aagtgaaagg 540
ctacggctca accggtagta agctttttga aactagagaa ctttgagtgc aggagaggag 600
agtagaattc ctagtgtagc ggtgaaatgc gtaaatttag gaggaatacc agtagcgaag 660
gcggcttctc tggacttgta actgacactg aggccgaaag cgggggagca acaggattag 720
atccctggta gtcccgccgt aaacgatgag tactagggtg tcgggggtta cccccctcgg 780
tgccgcagct aacgcattaa gtactccgcc tgggaagtac gctcgcaaga gtaaactcaa 840
aggaattgac cgggacccgc acaaagtagc ggagcatgtg gtttaattcg aagcaaacgc 900
gaagaacctt acctaagctt gacatcccac tgacctctcc ctaaatcgga gatttccctt 960
cggggccagt ggtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 1020
ttaagtcccg caacgagcgc aacccttgcc tttagttgcc agcattaagt tgggcactct 1080
agagggactg ccgaggataa ctcggaggaa ggtggggatg acgtcaaatc atcatgcccc 1140
ttatgcttag ggctacacca ccgtgctaca atgggtggta cagagggttg ccaagccgcg 1200
aaggtggagc taatccctta aagccattct cagttcggat tgtaggctga aactcgccta 1260
catgaagctg gagttactag taatcgcaat cagaatgctg cggtgatgcg ttcccgggtc 1320
ttgtacacac cgcccgtcac accattggaa gttggggcgc caga 1364
<210> 196
<211> 1471
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sp_NML_04A032
<400> 196
acgctggcgg cgtgcttaac acatgcaagt cgaacggggt gcctatgata gaggattcgt 60
ccaattgatt aggctaccta gtggcggacg ggtgagtaac gcgtgagtaa cctgccttgg 120
agtggggaat aacagtccga aaggactgct aataccgcat gatgcagcga ggtcgcatgg 180
ccttgctgcc aaagatttat cgctctgaga tggactcgcg tctgattagc tggttggcgg 240
ggtaacggcc caccaaggcg acgatcagta gccggactga gaggttggcc ggccacattg 300
ggactgagac acggcccaga ctcctacggg aggcagcagt ggggaatatt gggcaatggg 360
cgcaagcctg acccagcaac gccgcgtgaa ggaagaaggc tctcgggttg taaacttctt 420
ttatcaggga cgaaagaaat gacggtacct gatgaataag ccacggctaa ctacgtgcca 480
gcagccgcgg taatacgtag gtggcaagcg ttatccggat ttactgggtg taaagggcgt 540
gtaggcggga aagcaagtca ggcgtgaaaa ctatgggctc aacccatagc ctgcgtttga 600
aactgttttt cttgagtgtc ggagaggcaa tcggaattcc gtgtgtagcg gtgaaatgcg 660
tagatatacg gaggaacacc agtggcgaag gcggattgct ggacgataac tgacgctgag 720
gcgcgaaagc gtggggagca aacaggatta gataccctgg tagtccacgc cgtaaacgat 780
ggatactagg tgtggggggt ctgaccccct ccgtgccgca gttaacacaa taagtatccc 840
acctggggag tacgatcgca aggttgaaac tcaaaggaat tgacgggggc ccgcacaagc 900
ggtggagtat gtggtttaat tcgaagcaac gcgaagaacc ttaccagggc ttgacatcgt 960
actaacgaag cagagatgca ttaggtgccc ttcggggaaa gtatagacag gtggtgcatg 1020
gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaaccccta 1080
ttgttagttg ctacgcaaga gcactctagc gagactgccg ttgacaaaac ggaggaaggt 1140
ggggacgacg tcaaatcatc atgcccctta tgtcctgggc cacacacgta ctacaatggc 1200
ggtcaacaga gggaggcaat accgcgaggt ggagcaaatc cctaaaagcc gtcccagttc 1260
ggattgcagg ctgaaacccg cctgcatgaa gttggaatcg ctagtaatcg cggatcagca 1320
tgccgcggtg aatacgttcc cgggccttgt acacaccgcc cgtcacacca tgagagtcgg 1380
gaacacccga agtccgtagc ctaaccgcaa ggggggcgcg gccgaaggtg ggttcgataa 1440
ttggggtgaa gtcgtaacaa ggtagccgta t 1471
<210> 197
<211> 1320
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_sp_YIT_12069
<400> 197
gacgaacgct ggcggcgtgc ctaacacatg caagtcgaac gagtggcgga cgggtgagta 60
acgcgtgagc aacctgcctc aaagaggggg ataacgtctg gaaacggacg ctaataccgc 120
atgaccaaag ccgctttgag atgggctcgc gtctgattag ctagttggtg gggtaaaggc 180
ctaccaaggc gacgatcagt agccggactg agaggttgaa cggccacatt gggactgaga 240
cacggcccag actcctacgg gaggcagcag tgggggatat tgcacaatgg gggaaaccct 300
gatgcagcaa cgccgcgtga aggaagacgg ttttcggatt gtaaacttct gttcttagtg 360
acgatgacgg tagctaagga gaaagctccg gctaactacg tgccagcagc cgcggtaata 420
cgtagggagc gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggagatca 480
agtcagatgt gaaaactatg ggctcaaccc ataacctgca tttgaaactg ttcttcttga 540
gtgaagtaga ggcaggcgga attccgagtg tagcggtgaa atgcgtagat attcggagga 600
acaccagtgg cgaaggcggc ctgctgggct tactgacgct gaggctcgaa agcatgggga 660
gcaaacagga ttagataccc tggtagtcca tgccgtaaac gatgattact aggtgtgggg 720
tattccgtgc cggagttaac acaataagta atccacctgg ggagtacggc cgcaaggttg 780
aaactcaaag gaattgacgg gggcccgcac aagcagtgga gtatgtggtt taattcgaag 840
caacgcgaag aaccttacca ggtcttgaca tcgacaggtg gtgcatggtt gtcgtcagct 900
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccttgtca ttagttgcta 960
cagcactcta atgagactgc cgttgacaaa acggaggaag gtggggacga cgtcaaatca 1020
tcatgcccct tatgacctgg gctacacacg tactacaatg gccgtcagag ggaagcaata 1080
ctgtgaagtg gagcaaaccc ctacggtccc agttcagatg caggctgcaa cccgcctgca 1140
gaagtcggaa ttgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 1200
tgtacacacc gcccgtcaca ccatgggagc cggtaatacc cgaagtcggt gtctaggacg 1260
ccgccgaagg taggattggc gactggggtg aagtcgtaac aaggtagccg tatcggaagg 1320
<210> 198
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_symbiosum
<400> 198
ttaaacatga gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc 60
aagtcgaacg aagcaattta acggaagttt tcggatggaa gttgaattga ctgagtggcg 120
gacgggtgag taacgcgtgg gtaacctgcc ttgtactggg ggacaacagt tagaaatgac 180
tgctaatacc gcataagcgc acagtatcgc atgatacagt gtgaaaaact ccggtggtac 240
aagatggacc cgcgtctgat tagctagttg gtaaggtaac ggcttaccaa ggcgacgatc 300
agtagccgac ctgagagggt gaccggccac attgggactg agacacggcc caaactccta 360
cgggaggcag cagtggggaa tattgcacaa tgggcgaaag cctgatgcag cgacgccgcg 420
tgagtgaaga agtatttcgg tatgtaaagc tctatcagca gggaagaaaa tgacggtacc 480
tgactaagaa gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc 540
gttatccgga tttactgggt gtaaagggag cgtagacggt aaagcaagtc tgaagtgaaa 600
gcccgcggct caactgcggg actgctttgg aaactgttta actggagtgt cggagaggta 660
agtggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa 720
ggcgacttac tggacgataa ctgacgttga ggctcgaaag cgtggggagc aaacaggatt 780
agataccctg gtagtccacg ccgtaaacga tgaatactag gtgttgggga gcaaagctct 840
tcggtgccgt cgcaaacgca gtaagtattc cacctgggga gtacgttcgc aagaatgaaa 900
ctcaaaggaa ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 960
cgcgaagaac cttaccaggt cttgacatcg atccgacggg ggagtaacgt ccccttccct 1020
tcggggcgga gaagacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 1080
ttaagtcccg caacgagcgc aacccttatt ctaagtagcc agcggttcgg ccgggaactc 1140
ttgggagact gccagggata acctggagga aggtggggat gacgtcaaat catcatgccc 1200
cttatgatct gggctacaca cgtgctacaa tggcgtaaac aaagagaagc aagaccgcga 1260
ggtggagcaa atctcaaaaa taacgtctca gttcggactg caggctgcaa ctcgcctgca 1320
cgaagctgga atcgctagta atcgcgaatc agaatgtcgc ggtgaatacg ttcccgggtc 1380
ttgtacacac cgcccgtcac accatgggag tcagtaacgc ccgaagtcag tgacccaacc 1440
gtaaggaggg agctgccgaa ggcgggaccg ataactgggg tgaagtcgta acaaggtagc 1500
cgtatcggaa ggtgcggctg gatcacctcc tttct 1535
<210> 199
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_symbiosum
<400> 199
ttaaacatga gagtttgatc ctggctcagg atgaacgctg gcggcgtgcc taacacatgc 60
aagtcgaacg aagcgattca acggaaattt tcggatggaa gttgaattga ctgagtggcg 120
gacgggtgag taacgcgtgg gtaacctgcc ttgtactggg ggacaacagt tagaaatgac 180
tgctaatacc gcataagcgc acagtatcgc atgatacagt gtgaaaaact ccggtggtac 240
aagatggacc cgcgtctgat tagctagttg gtaaggtaac ggcttaccaa ggcgacgatc 300
agtagccgac ctgagagggt gaccggccac attgggactg agacacggcc caaactccta 360
cgggaggcag cagtggggaa tattgcacaa tgggcgaaag cctgatgcag cgacgccgcg 420
tgagtgaaga agtatttcgg tatgtaaagc tctatcagca gggaagaaaa tgacggtacc 480
tgactaagaa gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc 540
gttatccgga tttactgggt gtaaagggag cgtagacggt aaagcaagtc tgaagtgaaa 600
gcccgcggct caactgcggg actgctttgg aaactgttta actggagtgt cggagaggta 660
agtggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa 720
ggcgacttac tggacgataa ctgacgttga ggctcgaaag cgtggggagc aaacaggatt 780
agataccctg gtagtccacg ccgtaaacga tgaatactag gtgttgggga gcaaagctct 840
tcggtgccgt cgcaaacgca gtaagtattc cacctgggga gtacgttcgc aagaatgaaa 900
ctcaaaggaa ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 960
cgcgaagaac cttaccaggt cttgacatcg atccgacggg ggagtaacgt ccccttccct 1020
tcggggcgga gaagacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 1080
ttaagtcccg caacgagcgc aacccttatt ctaagtagcc agcggttcgg ccgggaactc 1140
ttgggagact gccagggata acctggagga aggtggggat gacgtcaaat catcatgccc 1200
cttatgatct gggctacaca cgtgctacaa tggcgtaaac aaagagaagc aagaccgcga 1260
ggtggagcaa atctcaaaaa taacgtctca gttcggactg caggctgcaa ctcgcctgca 1320
cgaagctgga atcgctagta atcgcgaatc agaatgtcgc ggtgaatacg ttcccgggtc 1380
ttgtacacac cgcccgtcac accatgggag tcagtaacgc ccgaagtcag tgacccaacc 1440
gcaaggaggg agctgccgaa ggcgggaccg ataactgggg tgaagtcgta acaaggtagc 1500
cgtatcggaa ggtgcggctg gatcacctcc tttct 1535
<210> 200
<211> 1482
<212> DNA
<213> Artificial Sequence
<220>
<223> Clostridium_viride
<220>
<221> misc_feature
<222> (746)..(746)
<223> n is a, c, g, or t
<400> 200
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac ggagccatct ggaacaagtt 60
ttcggacaag ggaaagatgt gcttagtggc ggacgggtga gtaacgcgtg agtaacctgc 120
cttggagtgg ggaataacac atcgaaaggt gtgctaatac cgcatgatgc aacgggatcg 180
catggttctg ttgccaaaga tttatcgctc tgagatggac tcgcgtctga ttagctagtt 240
ggtgaggtaa tggctcacca aggcgacgat cagtagccgg actgagaggt tgaccggcca 300
cattgggact gagacacggc ccagactcct acgggaggca gcagtgggga atattgggca 360
atgggcgcaa gcctgaccca gcaacgccgc gtgaaggaag aaggccctcg ggttgtaaac 420
ttcttttatt cgagacgaaa caaatgacgg taccgaatga ataagccacg gctaactacg 480
tgccagcagc cgcggtaata cgtaggtggc aagcgttatc cggatttact gggtgtaaag 540
ggcgtgtagg cgggactgca agtcagatgt gaaattccag ggctcaactc tggacctgca 600
tttgaaactg tagttcttga gtgatggaga ggcaggcgga attccgagtg tagcggtgaa 660
atgcgtagat attcggagga acaccagtgg cgaaggcggc ctgctggaca ttaactgacg 720
ctgaggcgcg aaagcgtggg gagcanacag gattagatac cctggtagtc cacgctgtaa 780
acgatggata ctaggtgtgg ggggactgac cccttccgtg ccgcagttaa cacaataagt 840
atcccacctg gggagtacga tcgcaaggtt gaaactcaaa ggaattgacg ggggcccgca 900
caagcggtgg agtatgtggt ttaattcgaa gcaacgcgaa gaaccttacc agggcttgac 960
atccctctga ccggtctaga gataggccct ccctcggggc agaggtgaca ggtggtgcat 1020
ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaacccct 1080
attgttagtt gctacgcaag agcactctag cgagactgcc gttgacaaaa cggaggaagg 1140
tggggacgac gtcaaatcat catgcccctt atgtcctggg ctacacacgt actacaatgg 1200
cgcttaacag agggaggcaa taccgcgagg tggagcaaac ccctaaaagg cgtcccagtt 1260
cggattgcag gctgaaaccc gcctgtatga agttggaatc gctagtaatc gcggatcagc 1320
atgccgcggt gaatacgttc ccgggtcttg tacacaccgc ccgtcacacc atgagagtcg 1380
ggaacacccg aagtccgtag cctaacagca atgagggcgc ggccgaaggt gggttcgata 1440
attggggtga agtcgtaaca aggtagccgt atcggaaggt gc 1482
<210> 201
<211> 1511
<212> DNA
<213> Artificial Sequence
<220>
<223> Collinsella_aerofaciens
<400> 201
tttggacgga gagttcgatc ctggctcagg atgaacgctg gcggcgcgcc taacacatgc 60
aagtcgaacg gcacccctct ccggagggaa gcgagtggcg aacggctgag taacacgtgg 120
agaacctgcc ccctcccccg ggatagccgc ccgaaaggac gggtaatacc ggataccccg 180
gggtgccgca tggcgccccg gctaaagccc cgacgggagg ggatggctcc gcggcccatc 240
aggtagacgg cggggtgacg gcccaccgtg ccgacaacgg gtagccgggt tgagagaccg 300
accggccaga ttgggactga gacacggccc agactcctac gggaggcagc agtggggaat 360
cttgcgcaat ggggggaacc ctgacgcagc gacgccgcgt gcgggacgga ggccttcggg 420
tcgtaaaccg ctttcagcag ggaagagtca agactgtacc tgcagaagaa gccccggcta 480
actacgtgcc agcagccgcg gtaatacgta gggggcgagc gttatccgga ttcattgggc 540
gtaaagcgcg cgtaggcggc ccggcaggcc gggggtcgaa gcggggggct caaccccccg 600
aagcccccgg aacctccgcg gcttgggtcc ggtaggggag ggtggaacac ccggtgtagc 660
ggtggaatgc gcagatatcg ggtggaacac cggtggcgaa ggcggccctc tgggccgaga 720
ccgacgctga ggcgcgaaag ctgggggagc gaacaggatt agataccctg gtagtcccag 780
ccgtaaacga tggacgctag gtgtgggggg acgatccccc cgtgccgcag ccaacgcatt 840
aagcgtcccg cctggggagt acggccgcaa ggctaaaact caaaggaatt gacgggggcc 900
cgcacaagca gcggagcatg tggcttaatt cgaagcaacg cgaagaacct taccagggct 960
tgacatatgg gtgaagcggg ggagaccccg tggccgagag gagcccatac aggtggtgca 1020
tggctgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaacccc 1080
cgccgcgtgt tgccatcggg tgatgccggg aacccacgcg ggaccgccgc cgtcaaggcg 1140
gaggagggcg gggacgacgt caagtcatca tgccccttat gccctgggct gcacacgtgc 1200
tacaatggcc ggtacagagg gatgccaccc cgcgaggggg agcggatccc ggaaagccgg 1260
ccccagttcg gattgggggc tgcaacccgc ccccatgaaa gtcggagttg ctagtaatcg 1320
cggatcagca tgccgcggtg aatgcgttcc cgggccttgt acacaccgcc cgtcacacca 1380
cccgagtcgt ctgcacccga agtcgccggc ccaaccgaga ggggggaggc gccgaaggtg 1440
tggagggtga ggggggtgaa gtcgtaacaa ggtagccgta ccggaaggtg cggctggatc 1500
acctcctttc t 1511
<210> 202
<211> 1511
<212> DNA
<213> Artificial Sequence
<220>
<223> Collinsella_intestinalis
<400> 202
ttggacggag agttcgatcc tggctcagga tgaacgctgg cggcgcgcct aacacatgca 60
agtcgaacgg cacccaccct cgggtggaag cgagtggcga acggctgagt aacacgtgga 120
gaacccgccc cctcctccgg gatagcctcg ggaaaccgtg ggtaataccg gatgaccccg 180
cagggccgca tggccccgcg ggcaaagccc agacgggagg ggatggctcc gcggcccatc 240
aggtagacgg cggggtgacg gcccaccgtg ccgacgacgg gtagccgggt tgagagaccg 300
accggccaga ttgggactga gacacggccc agactcctac gggaggcagc agtggggaat 360
cttgcgcaat ggggggaacc cgtgacgcag cgacgccgcg tgcgggacga aggccctcgg 420
gtcgtaaacc gctttcagca gggatgagac aagacggtac ctgcagaaga agccccggct 480
aactacgtgc cagcagccgc ggtaatacgt agggggcgag cgttatccgg attcattggg 540
cgtaaagcgc gcgtaggcgg cccggcaggc agggggtcaa atggcggggc tcaaccccgt 600
cccgccccct gaaccgccgg gctcgggtcc ggtaggggag ggtggaacac ccggtgtagc 660
ggtggaatgc gcagatatcg ggtggaacac cggtggcgaa ggcggccctc tgggccgaga 720
ccgacgctga ggcgcgaaag ctgggggagc gaacaggatt agataccctg gtagtcccag 780
ccgtaaacga tggacgctag gtgtgggggg acgatccctc cgtgccgcag ccaacgcatt 840
aagcgtcccg cctggggagt acggccgcaa ggctaaaact caaaggaatt gacgggggcc 900
cgcacaagca gcggagcatg tggcttaatt cgaagcaacg cgaagaacct taccagggct 960
tgacatgacc gtgaagccgg ggagacccgg tggccgagag gagcggtcac aggtggtgca 1020
tggctgtcgt cagctcgtgt cgtgagatgt ttggttaagt ccagcaacga gcgcaacccc 1080
cgccgccatg ttgccagcac ctcgggtggg gcacccatgc gggaccgccg gagtcaatcc 1140
ggaggagggc ggggacgacg tcaagtcatc atgcccctta tgccctgggc tgcacacgtg 1200
ctacaatggc cggtacagcg ggatgcgatg gcgcgagccg gagcggatcc ctgaaagccg 1260
gccccagttc ggattggggg ctgcaacccg cccccatgaa gtcggagttg ctagtaatcg 1320
cggatcagca tgccgcggtg aatgcgttcc cgggccttgt acacaccgcc cgtcacacca 1380
cccgagtcgt ctgcacccga agtcgccggc ccaaccatct ggggggaggc gccgaaggtg 1440
tggagggtga ggggggtgaa gtcgtaacaa ggtagccgta cgggaacgtg cggctggatc 1500
acctcctttc t 1511
<210> 203
<211> 1509
<212> DNA
<213> Artificial Sequence
<220>
<223> Collinsella_stercoris
<400> 203
tttggacgga gagttcgatc ctggctcagg atgaacgctg gcggcgcgcc taacacatgc 60
aagtcgaacg gcacccgccc tcgggcggaa gcgagtggcg aacggctgag taacacgtgg 120
agaacccgcc ccctcctccg ggatagcctc gggaaaccgt gggtaatacc ggatgacccc 180
ggcaggccgc atggccggcc gggcaaagcc cagacgggag gggatggctc cgcggcccat 240
caggtagacg gcggggtgac ggcccaccgt gccgacgacg ggtagccggg ttgagagacc 300
gaccggccag attgggactg agacacggcc cagactccta cgggaggcag cagtggggaa 360
tcttgcgcaa tggggggaac cctgacgcag cgacgccgcg tgcgggacga aggccctcgg 420
gtcgtaaacc gctttcagca gggatgagac aagacggtac ctgcagaaga agccccggct 480
aactacgtgc cagcagccgc ggtaatacgt agggggcgag cgttatccgg attcattggg 540
cgtaaagcgc gcgtaggcgg cccggcaggc agggggtcaa atggcggggc tcaaccccgt 600
cccgccccct gaaccgccgg gctcgggtcc ggtaggggag ggtggaacac ccggtgtagc 660
ggtggaatgc gcagatatcg ggtggaacac cggtggcgaa ggcggccctc tgggccgaga 720
ccgacgctga ggcgcgaaag ctgggggagc gaacaggatt agataccctg gtagtcccag 780
ccgtaaacga tggacgctag gtgtgggagg ggaacccttc cgtgccgcag ccaacgcatt 840
aagcgtcccg cctggggagt acggccgcaa ggctaaaact caaaggaatt gacgggggcc 900
cgcacaagca gcggagcatg tggcttaatt cgaagcaacg cgaagaacct taccagggct 960
tgacatgcgc gtgaagccgg ggagacccgg tggccgagag gagcgcgcac aggtggtgca 1020
tggctgtcgt cagctcgtgt cgtgagatgt ttggttaagt ccagcaacga gcgcaacccc 1080
cgccgcatgt tgccagcacc tcgggtgggc acccatgcgg gaccgccgga gtcaatccgg 1140
aggagggcgg ggacgacgtc aagtcatcat gccccttatg ccctgggctg cacacgtgct 1200
acaatggccg gtacagcggg atgcgatggc gcgagccgga gcggatccct gaaagccggc 1260
cccagttcgg attgggggct gcaacccgcc cccatgaagt cggagttgct agtaatcgcg 1320
gatcagcatg ccgcggtgaa tgcgttcccg ggccttgtac acaccgcccg tcacaccacc 1380
cgagtcgtct gcacccgaag tcgccggccc aaccgagagg ggggaggcgc ctaaggtgtg 1440
gagggtgagg ggggtgaagt cgtaacaagg tagccgtacg ggaacgtgcg gctggatcac 1500
ctcctttct 1509
<210> 204
<211> 1356
<212> DNA
<213> Artificial Sequence
<220>
<223> Collinsella_tanakaei
<400> 204
tcatggctca ggatgaacgc tggcggcgcg cctaacacat gcaagtcgaa cgagtggcga 60
acggctgagt aacacgtgga gaacctgccc cctcctcggg gatagccgcg ggaaaccgcg 120
ggtaacaccc gacgaccaaa tgagggaggg gatggctccg cggcccatca ggtagacggc 180
ggggtaacgg cccaccgtgc cgacaacggg tagccgggtt gagagaccga ccggccagat 240
tgggactgag acacggccca gactcctacg ggaggcagca gtggggaatc ttgcgcaatg 300
ggggcaaccc tgacgcagcg acgccgcgtg cgggacgaag gccttcgggt cgtaaaccgc 360
tttcagcagg gacgaagacg gtacctgcag aagaagcccc ggctaactac gtgccagcag 420
ccgcggtaat acgtaggggg cgagcgttat ccggattcat tgggcgtaaa gcgcgcgtag 480
gcggccgcgt aggcgggggg tcaaatcccg gggctcaacc ccggtccgcc ccccgaaccc 540
cgcggctcgg gtccggtagg ggagggtgga attcccggtg tagcggtgga atgcgcagat 600
atcgggagga acaccggtgg cgaaggcggc cctctgggcc gaccgacgct gaggcgcgaa 660
agctggggga gcgaacagga ttagataccc tggtagtccc agccgtaaac gatggacgct 720
aggtgtgggg gcctccgtgc cgcagccaac gcattaagcg tcccgcctgg ggagtacggc 780
cgcaaggcta aaactcaaag gaattgacgg gggcccgcac aagcagcgga gcatgtggct 840
taattcgaag caacgcgaag aaccttacca gggcttgaca tgcacaggtg gtgcatggct 900
gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccccgccg 960
catgttgcca gcagctgggc acccatgcgg gaccgccggc gtcaagccgg aggagggcgg 1020
ggacgacgtc aagtcatcat gccccttatg ccctgggctg cacacgtgct acaatggccg 1080
gcagcgggat gcgatggcgc gagccggagc ggatccctcc cggccccagt tcggatgggg 1140
gctgcaaccc gcccccagaa gtcggagttg ctagtaatcg cggatcagca tgccgcggtg 1200
aatgcgttcc cgggccttgt acacaccgcc cgtcacacca cccgagtcgt ctgcacccga 1260
agccgccgcc cagggaggcg tcgaaggtgt ggagggtgag gggggtgaag tcgtaacaag 1320
gtagccgtac gggaacgtgc ggctggatca cctcct 1356
<210> 205
<211> 1325
<212> DNA
<213> Artificial Sequence
<220>
<223> Collinsella_tanakaei
<400> 205
gatgaacgct ggcggcgcgc ctaacacatg caagtcgaac gagtggcgaa cggctgagta 60
acacgtggag aacctgcccc ctcctcgggg atagccgcgg gaaaccgcgg gtaacacccg 120
acgaccaaat gagggagggg atggctccgc ggcccatcag gtagacggcg gggtaacggc 180
ccaccgtgcc gacaacgggt agccgggttg agagaccgac cggccagatt gggactgaga 240
cacggcccag actcctacgg gaggcagcag tggggaatct tgcgcaatgg gggcaaccct 300
gacgcagcga cgccgcgtgc gggacgaagg ccttcgggtc gtaaaccgct ttcagcaggg 360
acgaagacgg tacctgcaga agaagccccg gctaactacg tgccagcagc cgcggtaata 420
cgtagggggc gagcgttatc cggattcatt gggcgtaaag cgcgcgtagg cggccgcgta 480
ggcggggggt caaatcccgg ggctcaaccc cggtccgccc cccgaacccc gcggctcggg 540
tccggtaggg gagggtggaa ttcccggtgt agcggtggaa tgcgcagata tcgggaggaa 600
caccggtggc gaaggcggcc ctctgggccg accgacgctg aggcgcgaaa gctgggggag 660
cgaacaggat tagataccct ggtagtccca gccgtaaacg atggacgcta ggtgtggggg 720
cctccgtgcc gcagccaacg cattaagcgt cccgcctggg gagtacggcc gcaaggctaa 780
aactcaaagg aattgacggg ggcccgcaca agcagcggag catgtggctt aattcgaagc 840
aacgcgaaga accttaccag ggcttgacat gcacaggtgg tgcatggctg tcgtcagctc 900
gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccccgccgc atgttgccag 960
cagctgggca cccatgcggg accgccggcg tcaagccgga ggagggcggg gacgacgtca 1020
agtcatcatg ccccttatgc cctgggctgc acacgtgcta caatggccgg cagcgggatg 1080
cgatggcgcg agccggagcg gatccctccc ggccccagtt cggatggggg ctgcaacccg 1140
cccccagaag tcggagttgc tagtaatcgc ggatcagcat gccgcggtga atgcgttccc 1200
gggccttgta cacaccgccc gtcacaccac ccgagtcgtc tgcacccgaa gccgccgccc 1260
agggaggcgt cgaaggtgtg gagggtgagg ggggtgaagt cgtaacaagg tagccgtacg 1320
ggaac 1325
<210> 206
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> Coprobacillus_sp_D7
<400> 206
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaatacat gcaagtcgaa 60
cgcgagcact tgtgctcgag tggcgaacgg gtgagtaata cataagtaac ctgccctaga 120
cagggggata actattggaa acgatagcta agaccgcata ggtacggaca ctgcatggtg 180
accgtattaa aagtgcctca aagcactggt agaggatgga cttatggcgc attagctggt 240
tggcggggta acggcccacc aaggcgacga tgcgtagccg acctgagagg gtgaccggcc 300
acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aattttcggc 360
aatgggggaa accctgaccg agcaacgccg cgtgaaggaa gaaggttttc ggattgtaaa 420
cttctgttat aaaggaagaa cggcggctac aggaaatggt agccgagtga cggtacttta 480
ttagaaagcc acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt 540
atccggaatt attgggcgta aagagggagc aggcggcagc aagggtctgt ggtgaaagcc 600
tgaagcttaa cttcagtaag ccatagaaac caggcagcta gagtgcagga gaggatcgtg 660
gaattccatg tgtagcggtg aaatgcgtag atatatggag gaacaccagt ggcgaaggcg 720
acgatctggc ctgcaactga cgctcagtcc cgaaagcgtg gggagcaaat aggattagat 780
accctagtag tccacgccgt aaacgatgag tactaagtgt tggatgtcaa agttcagtgc 840
tgcagttaac gcaataagta ctccgcctga gtagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg gggcccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca ggtcttgaca tactcataaa ggctccagag atggagagat agctatatga 1020
gatacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 1080
aacgagcgca acccttatcg ttagttacca tcattaagtt ggggactcta gcgagactgc 1140
cagtgacaag ctggaggaag gcggggatga cgtcaaatca tcatgcccct tatgacctgg 1200
gctacacacg tgctacaatg gatggtgcag agggaagcga agccgcgagg tgaagcaaaa 1260
cccataaaac cattctcagt tcggattgta gtctgcaact cgactacatg aagttggaat 1320
cgctagtaat cgcgaatcag catgtcgcgg tgaatacgtt ctcgggcctt gtacacaccg 1380
cccgtcacac cacgagagtt gataacaccc gaagccggtg gcctaaccgc aaggaaggag 1440
ctgtctaagg tgggattgat gattggggtg aagtcgtaac aaggtatccc tacgggaacg 1500
tggggatgga tcacctcctt tctaagga 1528
<210> 207
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Coprococcus_comes
<400> 207
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcactt taacctgatt cttcggatga aggtttttgt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataaga ccacagagcc gcatggctcg gtgggaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attaggtagt tggtggggta acggcctacc aagccaacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgaa 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gctgtgtaag tctgaagtga aagcccgggg 600
ctcaaccccg ggactgcttt ggaaactatg cagctagagt gtcggagagg taagtggaat 660
tcccagtgta gcggtgaaat gcgtagatat tgggaggaac accagtggcg aaggcggctt 720
actggacgat gactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg gagcaaagct cttcggtgcc 840
gcagcaaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg ctcttgacat cccggtgacc ggcgtgtaat gacgcctttt cttcggaaca 1020
ccggtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctta tcttcagtag ccagcaattc ggatgggcac tctggagaga 1140
ctgccaggga taacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgag 1200
cagggctaca cacgtgctac aatggcgtaa acaaagggaa gcgagcctgc gagggtaagc 1260
aaatctcaaa aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg 1320
gaatcgctag taatcgcgaa tcagcatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agttggtaac gcccgaagtc agtgacccaa ccgtaaggag 1440
ggagctgccg aaggtgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 208
<211> 1440
<212> DNA
<213> Artificial Sequence
<220>
<223> Coprococcus_eutactus
<400> 208
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gattgaagct ggagcttgct 60
ccggccgatt tagtggcgga cgggtgagta acgcgtgggt aacctgcctc atacaggggg 120
atagcagttg gaaacgactg gtaaaaccgc ataagcgcac rgtatcgcat gatacagtgt 180
gaaaacactc cggtggtatg agatggaccc gcgtctgatt agctagttgg tgaggtaacg 240
gcccaccaag gcgacgatca gtagccggcc tgagagggtg aacggccaca ttgggactga 300
gacacggccc aaactcctac gggaggcagc agtggggaat attgcacaat gggggaaacc 360
ctgatgcagc gacgccgcgt gagtgaagaa gtatttcggt atgtaaagct ctatcagcag 420
ggaagataat gacggtacct gactaagaag caccggctaa atacgtgcca gcagccgcgg 480
taatacgtat ggtgcaagcg ttatccggat ttactgggtg taaagggtgc gtaggtggca 540
aggcaagtct gaagtgaaaa tccggggctc aaccccggaa ctgctttgga aactgtttag 600
ctagagtaca ggagaggtaa gtggaattcc tagtgtagcg gtgaaatgcg tagatattag 660
gaggaacacc agtggcgaag gcgacttact ggactgctac tgacactgag gcacgaaagc 720
gtggggagca aacaggatta gataccctgg tagtccacgc cgtaaacgat gaatactagg 780
tgttgggttc caaagggact cggtgccgtc gcaaacgcat taagtattcc acctggggag 840
tacgttcgca agaatgaaac tcaaaggaat tgacggggac ccgcacaagc ggtggagcat 900
gtggtttaat tcgaagcaac gcgaaaaacc ttaccaagtc ttgacatcct gatgacggtt 960
ccttaaccgg aacttctctt cggagcatca gagacaggtg gtgcatggtt gtcgtcagct 1020
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccctattt ccagtagcca 1080
gcagtaagat gggcactctg gagagactgc cggggataac ccggaggaag gtggggatga 1140
cgtcaaatca tcatgcccct tatgatttgg gctacacacg tgctacaatg gcagttacaa 1200
agagaagcra acctgtgaag gcgagcaaac ctcaaaaagg ctgtctcagt tcggattgta 1260
gtctgcaact cgactacatg aagctggaat cgctagtaat cgcagatcag catgctgcgg 1320
tgaatacgtt cccgggtctt gtacacaccg cccgtcacac catgggagtc ggtaacgccc 1380
gaagtcagtg acccaaccgc aaggagggag ctgccgaagg caggatcgat aactggggtg 1440
<210> 209
<211> 1464
<212> DNA
<213> Artificial Sequence
<220>
<223> Coriobacteriaceae_bacterium_phI
<400> 209
gatcctggct caggatgaac gctggcggcg cgcctaacac atgcaagtcg agcggcaccc 60
tgcttcggca ggaagcgagc ggcgaacggc tgagtaacac gtgaccaacc tgccctgcgc 120
acggggacag ccgcgggaaa ccgcgggtga tacccggtgg ccccgggggg acgcatgtcc 180
ccagcgggca tagctccggc ggcgcgggat ggggtcgcgg cccatcaggt agttggtagg 240
gtgacggcct accaagccga ctacgggtag ccgggttgag agaccgaccg gccagattgg 300
gactgagaca cggcccagac tcctacggga ggcagcagtg gggaatcttg cgcaatgggg 360
ggaaccctga cgcagcgacg ccgcgtgcgg gatggaggcc ttcgggtcgt gaaccgcttt 420
cagcagggac gagactgacg gtacctgcag aagaagcccc ggctaactac gtgccagcag 480
ccgcggtaat acgtaggggg cgagcgttat ccggattcat tgggcgtaaa gcgcgcgtag 540
gcggccgcgc aggcgggggg tcaaatcccg gggctcaacc ccgggccgcc ccccgaaccg 600
cgcggcttgg gtccggcagg ggagggtgga acgcccggtg tagcggtgga atgcgcagat 660
atcgggcgga acaccggtgg cgaaggcggc cctctgggcc ggcaccgacg ctgaggcgcg 720
agagccgggg gagcgaacag gattagatac cctggtagtc ccggccgtaa acgatggacg 780
ctaggtgtgg ggacgttgga gtctccgtgt gccgcagcca acgcattaag cgtcccgcct 840
ggggagtacg gccgcaaggc taaaactcaa aggaattgac gggggcccgc acaagcagcg 900
gagcatgtgg cttaattcga agcaacgcga agaaccttac ccgcgcttga catggcggtg 960
aagcggcgga gacgccgtgg ccgagaggag ccgccacagg tggtgcatgg ctgtcgtcag 1020
ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg caacccccgc cgcgtgttgc 1080
catcgggtga tgccgggaac ccacgcggga ccgccgccgc caaggcggag gagggcgggg 1140
acgacgtcaa gtcatcatgc cccttatgcg cggggctgca cacgtgctac aatggcaggt 1200
acagagggtt gccaccccgc gagggggagc ggatcccgaa agcctgcccc agttcggacc 1260
gggggctgca acccgccccc gcgaagtcgg agttgctagt aatcgcggat cagcatgccg 1320
cggtgaatgc gttcccgggc cttgtacaca ccgcccgtca caccacccga gtcgtctgca 1380
cccgaagccg ccggcccaac ctcgtgaggg aggcgtcgaa ggtgtggagg gcgagggggg 1440
tgaagtcgta acaaggtagc cgta 1464
<210> 210
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Dorea_formicigenerans
<400> 210
ttttaaacga gagtttgatc ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgagcg aagcacataa gttcgattct tcggatgaag acttttgtga ctgagcggcg 120
gacgggtgag taacgcgtgg gtaacctgcc tcatacaggg ggataacagc tagaaatggc 180
tgctaatacc gcataagacc acagtactgc atggtacagt ggtaaaaact ccggtggtat 240
gagatggacc cgcgtctgat taggtagttg gtgaggtaac ggcccaccaa gccgacgatc 300
agtagccgac ctgagagggt gaccggccac attgggactg agacacggcc cagactccta 360
cgggaggcag cagtggggaa tattgcacaa tgggcgaaag cctgatgcag cgacgccgcg 420
tgaaggatga agtatttcgg tatgtaaact tctatcagca gggaagaaaa tgacggtacc 480
tgactaagaa gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc 540
gttatccgga tttactgggt gtaaagggag cgtagacggc tgtgcaagtc tgaagtgaaa 600
ggcatgggct caacctgtgg actgctttgg aaactgtgca gctagagtgt cggagaggta 660
agtggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa 720
ggcggcttac tggacgatga ctgacgttga ggctcgaaag cgtggggagc aaacaggatt 780
agataccctg gtagtccacg ccgtaaacga tgactgctag gtgtcgggta gcaaagctat 840
tcggtgccgc agctaacgca ataagcagtc cacctgggga gtacgttcgc aagaatgaaa 900
ctcaaaggaa ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 960
cgcgaagaac cttacctgat cttgacatcc cgatgaccgc ttcgtaatgg aagcttttct 1020
tcggaacatc ggtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 1080
ttaagtcccg caacgagcgc aacccttatc ttcagtagcc agcatttagg atgggcactc 1140
tggagagact gccagggata acctggagga aggtggggat gacgtcaaat catcatgccc 1200
cttatgacca gggctacaca cgtgctacaa tggcgtaaac aaagggaagc agagccgcga 1260
ggccgagcaa atctcaaaaa taacgtctca gttcggattg tagtctgcaa ctcgactaca 1320
tgaagctgga atcgctagta atcgcagatc agaatgctgc ggtgaatacg ttcccgggtc 1380
ttgtacacac cgcccgtcac accatgggag tcagtaacgc ccgaagtcag tgacccaacc 1440
gaaaggaggg agctgccgaa ggtgggaccg ataactgggg tgaagtcgta acaaggtagc 1500
cgtatcggaa ggtgcggctg gatcacctcc tttct 1535
<210> 211
<211> 1316
<212> DNA
<213> Artificial Sequence
<220>
<223> Dorea_longicatena
<400> 211
taacgcgtgg gtaacctgcc tcatacaggg ggataacagt tagaaatgac tgctaatacc 60
gcataagacc acgtaccgca tggtacagtg gtaaaaactc cggtggtatg agatggaccc 120
gcgtctgatt aggtagttgg tggggtaacg gcctaccaag ccgacgatca gtagccgacc 180
tgagagggtg accggccaca ttgggactga gacacggccc agactcctac gggaggcagc 240
agtggggaat attgcacaat ggaggaaact ctgatgcagc gacgccgcgt gaaggatgaa 300
gtatttcggt atgtaaactt ctatcagcag ggaagaaaat gacggtacct gactaagaag 360
ccccggctaa ctacgtgcca gcagccgcgg taatacgtag ggggcaagcg ttatccggat 420
ttactgggtg taaagggagc gtagacggca cggcaagcca gatgtgaaaa gcccggggct 480
caaccccggg actgcatttg gaactgctga gctagagtgt cggagaggca agtggaattc 540
ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa ggcggcttgc 600
tggacgatga ctgacgttga ggctcgaaag cgtggggagc aaacaggatt agataccctg 660
gtagtccacg ccgtaaacga tgactgctag gtgtcgggtg gcaaagccat tcggtgccgc 720
agctaacgca ataagcagtc cacctgggga gtacgttcgc aagaatgaaa ctcaaaggaa 780
ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac 840
cttacctgat cttgacatcc cgatgaccgc ttcgtaatgg aagtttttct tcggaacatc 900
ggtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 960
caacgagcgc aacccctatc ttcagtagcc agcaggttaa gctgggcact ctggagagac 1020
tgccagggat aacctggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 1080
agggctacac acgtgctaca atggcgtaaa caaagagaag cgaactcgcg agggtaagca 1140
aatctcaaaa ataacgtctc agttcggatt gtagtctgca actcgactac atgaagctgg 1200
aatcgctagt aatcgcagat cagaatgctg cggtgaatac gttcccgggt cttgtacaca 1260
ccgcccgtca caccatggga gtcataacgc ccgaagtcag tgacccaacc gtaagg 1316
<210> 212
<211> 1505
<212> DNA
<213> Artificial Sequence
<220>
<223> Eggerthella_sp_1_3_56FAA
<400> 212
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaacacat gcaagtcgaa 60
cgatgaaacc gccctcgggc ggacatgaag tggcgaacgg gtgagtaaca cgtgaccaac 120
ctgcccccct ctccgggaca accttgggaa accgaggcta ataccggata ctccctcccc 180
tgctcctgca ggggtcggga aagcccaggc ggagggggat ggggtcgcgg cccattaggt 240
agtaggcggg gtaacggccc acctagcccg cgatgggtag ccgggttgag agaccgaccg 300
gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg gggaattttg 360
cgcaatgggg gcaaccctga cgcagcaacg ccgcgtgcgg gacgacggcc ttcgggttgt 420
aaaccgcttt cagcagggaa gaaattcgac ggtacctgca gaagaagctc cggctaacta 480
cgtgccagca gccgcggtaa tacgtaggga gcgagcgtta tccggattca ttgggcgtaa 540
agagcgcgta ggcggcctct caagcgggat ctctaatccg agggctcaac ccccggccgg 600
atcccgaact gggaggctcg agttcggtag aggcaggcgg aattcccggt gtagcggtgg 660
aatgcgcaga tatcgggaag aacaccgatg gcgaaggcag cctgctgggc cgcaactgac 720
gctgaggcgc gaaagctagg ggagcgaaca ggattagata ccctggtagt cctagccgta 780
aacgatggat actaggtgtg gggggctccg ccctccgtgc cgcagccaac gcattaagta 840
tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag gaattgacgg gggcccgcac 900
aagcagcgga gcatgtggct taattcgaag caacgcgaag aaccttacca gggcttgaca 960
tggacgtgaa gccggggaaa cccggtggcc gagaggagcg tccgcaggtg gtgcatggct 1020
gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccctgccc 1080
catgttgcca gcattaggtt ggggactcat gggggactgc cggcgtcaag ccggaggaag 1140
gtggggacga cgtcaagtca tcatgccctt tatgccctgg gctgcacacg tgctacaatg 1200
gccggtacaa cgggctgcga gaccgcgagg tcgagcgaat ccctcaaagc cggccccagt 1260
tcggatcgga ggctgcaacc cgcctccgtg aagtcggagt tgctagtaat cgcggatcag 1320
catgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac cacccgagtc 1380
gtctgcaccc gaagccgccg gccgaacccg caaggggcgg aggcgtcgaa ggtgtggagg 1440
gtaagggggg tgaagtcgta acaaggtagc cgtaccggaa ggtgcggctg gatcacctcc 1500
tttct 1505
<210> 213
<211> 1543
<212> DNA
<213> Artificial Sequence
<220>
<223> Eremococcus_coleocola
<400> 213
atgagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 60
aacgcactga cggagaactt gttctcttaa cgtgagtggc ggacgggtga gtaacacgtg 120
ggaaacctac ccttgagcgg gggataacgg tcggaaacga tcgctaatac cgcataacag 180
caatcatcgc ctgatggttg attgaaagat ggctctgcta tcactcaagg atgggcccgc 240
ggtgcattag ctagttggta aggtaacggc ttaccaaggc catgatgcat agccgacctg 300
agagggtaat cggccacatt gggactgaga cacggcccaa actcctacgg gaggcagcag 360
tagggaatct tccgcaatgg acgcaagtct gacggagcaa cgccgcgtgt gtgaagaagg 420
ttttcggatc gtaaagcact gttattagcc aagaacaccc ctagtagtaa ctggctaggg 480
attgacggta actaatcaga aagccacggc taactacgtg ccagcagccg cggtaatacg 540
taggtggcaa gcgttgtccg gatttattgg gcgtaaaggg agcgcaggcg gtgacttaag 600
tctgatgtga aagcccacgg cttaaccgtg gagggtcatt ggaaactggg tcacttgagt 660
acagaagagg aaagcggaat tccatgtgta gcggtgaaat gcgtagatat atggaggaac 720
accagtggcg aaggcggctt tctggtctga tactgacgct gaggctcgaa agcgtgggga 780
gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttgga 840
gggtttccac ccttcagtgc tggcgttaac gcaataagca ctccgcctgg ggagtacggt 900
cgcaagactg aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt 960
taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctatgacc actctagaga 1020
tagagtttct cttcggagca tagagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 1080
gagatgttgg gttaagtccc gcaacgagcg caacccttat aactagttgc cagcattcag 1140
atggggactc tagttagact gccggtgaca aaccggagga aggtggggat gacgtcaaat 1200
catcatgccc cttatgacct gggctacaca cgtgctacaa tggacgatac aacgagcagc 1260
aaactcgcga gggcaagcga atctcttaaa gtcgttctca gttcggattg caggctgcaa 1320
ctcgcctgca tgaagccgga atcgctagta atcgtggatc agcacgccac ggtgaatccg 1380
ttcccgggtc ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagccgg 1440
tggcctaacc tatgagggag ccgtcgaagg tgggatagat gattggggtg aagtcgtaac 1500
aaggtagccg tatcggaagg tgcggctgga tcacctcctt tct 1543
<210> 214
<211> 1542
<212> DNA
<213> Artificial Sequence
<220>
<223> Erysipelotrichaceae_bacterium_3_1_
53
<400> 214
tcaaatggag agtttgatcc tggctcagga tgaacgctgg cggcatgcct aatacatgca 60
agtcgaacga agtctctagg agcttgcttc caaagagact tagtggcgaa cgggtgagta 120
acacgtaggt aacctgccca tgtgtctggg ataactgctg gaaacggtag ctaaaaccgg 180
ataggtatac ggagcgcatg ctctgtatat taaagcaccc ctcaaggtgt gaacatggat 240
ggacctgcgg cgcattagct agttggtgag gtaacggccc accaaggcga tgatgcgtag 300
ccggcctgag agggtaaacg gccacattgg gactgagaca cggcccaaac tcctacggga 360
ggcagcagta gggaattttc gtcaatgggg ggaaccctga acgagcaatg ccgcgtgagt 420
gaagaaggtc ttcggatcgt aaagctctgt tgtaagtgaa gaacggctca tagaggaaat 480
gctatgggag tgacggtagc ttaccagaaa gccacggcta actacgtgcc agcagccgcg 540
gtaatacgta ggtggcaagc gttatccgga atcattgggc gtaaagggtg cgtaggtggc 600
gtactaagtc tgtagtaaaa ggcaatggct caaccattgt aagctatgga aactggtagg 660
ctagagtgca gaagagggcg atggaattcc atgtgtagcg gtaaaatgcg tagatatatg 720
gaggaacacc agtggcgaag gcggtcgcct ggtctgtaac tgacactgag gcacgaaagc 780
gtggggagca aataggatta gataccctag tagtccacgc cgtaaacgat gagaactaag 840
tgttggagga attcagtgct gcagttaacg caataagttc tccgcctggg gagtatgcac 900
gcaagtgtga aactcaaagg aattgacggg ggcccgcaca agcggtggag tatgtggttt 960
aattcgaagc aacgcgaaga accttaccag gccttgacat ggatgcaaag gctctagaga 1020
tagagagata attatggatc acacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag 1080
atgttgggtt aagtcccgca acgagcgcaa cccttgtcgc atgttaccag catcaagttg 1140
gggactcatg cgagactgcc ggtgacaaac cggaggaagg tggggatgac gtcaaatcat 1200
catgcccctt atggcctggg ctacacacgt actacaatgg cgaccacaaa gagcagcgac 1260
ttggtgacaa ggagcgaatc tcataaaggc cgtctcagtt cggattgaag tctgcaactc 1320
gacttcatga agtcggaatc gctagtaatc gcagatcagc atgctgcggt gaatacgttc 1380
tcgggccttg tacacaccgc ccgtcaaacc atgggagtca gtaatacccg aagccggtgg 1440
cataaccgta aggagtgagc cgtcgaaggt aggaccgatg actggggtta agtcgtaaca 1500
aggtatccct acgggaacgt ggggatggat cacctccttt ct 1542
<210> 215
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_barkeri
<220>
<221> misc_feature
<222> (617)..(618)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1473)..(1473)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1475)..(1479)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1488)..(1493)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1504)..(1512)
<223> n is a, c, g, or t
<400> 215
tttaattgag agtttgatcc tggctcagga cgaacgctgg cggtatgctt aacacatgca 60
agtcgaacga gaagcttttt atggatcctt cgggagaaat aagagtggaa agtggcgaac 120
gggtgagtaa cgcgtgggta acctgcctca tggaaaggaa tagcctcggg aaactgggag 180
taaagcctta tattattaag acatcgcatg gtgttttaat gaaaactccg gtgccatgag 240
atggacccgc gtcccattag ctagttggtg agataacagc ccaccaaggc aacgatgggt 300
aaccggtctg agagggcgaa cggtcacact ggaactgaga cacggtccag actcctacgg 360
gaggcagcag tggggaatat tgcgcaatgg gggcaaccct gacgcagcaa taccgcgtga 420
gtgaagaagg ttttcggatc gtaaaactct tttattgggg aagaagaagt gacggtaccc 480
aatgaagaag tcccggctaa ctacgtgcca gcagccgcgg taatacgtag gggacaagcg 540
ttgtccggaa tcactgggcg taaagggcgc gtaggcggtt ttataagtca gatgtgaaag 600
gtaccggctc aaccggnnac gtgcatttga aactgtaaga cttgagtact ggagaggcaa 660
gtggaattcc tagtgtagcg gtgaaatgcg tagatattag gaggaacacc ggtggcgaag 720
gcggcttgct ggacagatac tgacgctgag gtgcgaaagc gtggggagcg aacaggatta 780
gataccctgg tagtccacgc cgtaaacgat gatgactagg tgttggggaa actcagtgcc 840
gcagttaaca cattaagtca tccgcctggg gagtacgacc gcaaggttga aactcaaagg 900
aattgacggg gacccgcaca agcagcggag catgtggttt aattcgaagc aacgcgaaga 960
accttaccag gccttgacat cctctgacca tcctagagat aggagatttc cttcgggaac 1020
agagagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaacccttg cctttagttg ccagcattaa gttgggcact ctaaagggac 1140
tgccgtagac aatacggagg aaggtgggga cgacgtcaaa tcatcatgcc ccttatggcc 1200
tgggctacac acgtgctaca atgggttggg acaaagggaa gcgaagccgc gaggtgaagc 1260
caatcccata aaacaacccc cagttcggat tgcaggctga aacccgcctg catgaagttg 1320
gagttgctag taatcgcaga tcagaatgct gcggtgaatg cgttcccggg tcttgtacac 1380
accgcccgtc acaccacgag agttggcaac acccgaagcc agtgagcgaa ccgcaaggac 1440
gcagctgtcg aaggtggggt cagtaattgg ggngnnnnng taacaagnnn nnngtatcgg 1500
aagnnnnnnn nngatcacct cctttct 1527
<210> 216
<211> 1474
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_callanderi
<400> 216
cgaacgctgg cggtatgctt aacacatgca agtcgaacga gaaagttttg aatgatcctt 60
cgggtgaaat tagaactgga aagtggcgaa cgggtgagta acgcgtgggt aacctgccct 120
atggaaagga atagcctcgg gaaactggga gtaaagcctt atattatggt tttgtcgcat 180
ggcaagatca tgaaaactcc ggtgccatag gatggacccg cgtcccatta gctagttggt 240
gagataacag cccaccaagg cgacgatggg taaccggtct gagagggcga acggtcacac 300
tggaactgag acacggtcca gactcctacg ggaggcagca gtggggaata ttgcgcaatg 360
ggggcaaccc tgacgcagca ataccgcgtg agtgaagaag gttttcggat cgtaaagctc 420
tgttattggg gaagaaaaca tgacggtacc caatgaggaa gtcccggcta actacgtgcc 480
agcagccgcg gtaatacgta ggggacaagc gttgtccgga atgactgggc gtaaagggcg 540
cgtaggcggt ctattaagtc tgatgtgaaa ggtaccggct caaccggtga agtgcattgg 600
aaactggtag acttgagtat tggagaggca agtggaattc ctagtgtagc ggtgaaatgc 660
gtagatatta ggaggaacac cagtggcgaa ggcggcttgc tggacaaata ctgacgctga 720
ggtgcgaaag cgtggggagc gaacaggatt agataccctg gtagtccacg ccgtaaacga 780
tgaatgctag gtgttgggga aactcagtgc cgcagttaac acaataagca ttccgcctgg 840
ggagtacgac cgcaaggttg aaactcaaag gaattgacgg ggacccgcac aagcagcgga 900
gcatgtggtt taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgacg 960
agcctagaga taggaagttt ccttcgggaa cagagagaca ggtggtgcat ggttgtcgtc 1020
agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaacccct gcctttagtt 1080
gccagcatta agttgggcac tctagaggga ctgccgtaga caatacggag gaaggtgggg 1140
atgacgtcaa atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggtctga 1200
acagagggcc gcgaagccgc gaggtgaagc aaatccctta aaacagatcc cagttcggat 1260
tgcaggctgc aactcgcctg catgaagttg gagttgctag taatcgcgga tcagaatgcc 1320
gcggtgaatg cgttcccggg tcttgtacac accgcccgtc acaccacgag agttggcaac 1380
acccgaagcc tgtgagagaa ccgcaaggac tcagcagtcg aaggtggggc tagtaattgg 1440
ggtgaagtcg taacaaggta gccgtatcgg aagg 1474
<210> 217
<211> 1524
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_contortum
<400> 217
tttgatcctg gctcaggatg aacgctggcg acgtgcttaa cacatgcaag tcgagcgaag 60
cactttactt tgatttcttc ggaatgaaag gttttgtgac tgagcggcgg acgggtgagt 120
aacgcgtggg taacctgcct catacagggg gataacagtt agaaatgact gctaataccg 180
cataagacca cagtaccgca tggtacagtg ggaaaaactc cggtggtatg agatggaccc 240
gcgtctgatt agctagttgg taaggtaacg gcttaccaag gcgacgatca gtagccgacc 300
tgagagggtg accggccaca ttgggactga gacacggccc aaactcctac gggaggcagc 360
agtggggaat attgcacaat gggggaaacc ctgatgcagc gacgccgcgt gaaggatgaa 420
gtatttcggt atgtaaactt ctatcagcag ggaagaaaat gacggtacct gactaagaag 480
ccccggctaa ctacgtgcca gcagccgcgg taatacgtag ggggcaagcg ttatccggat 540
ttactgggtg taaagggagc gtagacggtt atgtaagtct gatgtgaaaa cccggggctc 600
aaccccggga ctgcattgga aactatgtaa ctagagtgtc ggagaggtaa gtggaattcc 660
tagtgtagcg gtgaaatgcg tagatattag gaggaacacc agtggcgaag gcggcttact 720
ggacgatgac tgacgttgag gctcgaaagc gtggggagca aacaggatta gataccctgg 780
tagtccacgc cgtaaacgat gaatactagg tgtcgggtgg caaagccatt cggtgccgca 840
gcaaacgcaa taagtattcc acctggggag tacgttcgca agaatgaaac tcaaaggaat 900
tgacggggac ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 960
ttacctgctc ttgacatccc cctgaccggc gtgtaatggt gcctttcctt cgggacaggg 1020
gagacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 1080
aacgagcgca acccttatct ttagtagcca gcggtttggc cgggcactct agagagactg 1140
ccagggataa cctggaggaa ggtggggatg acgtcaaatc atcatgcccc ttatgagcag 1200
ggctacacac gtgctacaat ggcgtaaaca aagggaggcg aagccgtgag gtggagcaaa 1260
tcccaaaaat aacgtctcag ttcggattgt agtctgcaac tcgactacat gaagctggaa 1320
tcgctagtaa tcgcgaatca gaatgtcgcg gtgaatacgt tcccgggtct tgtacacacc 1380
gcccgtcaca ccatgggagt tggtaacgcc cgaagtcagt gacccaaccg caaggaggga 1440
gctgccgagg gtgggaccga taactggggt gaagtcgtaa caaggtagcc gtatcggaag 1500
gtgcggctgg atcacctcct ttct 1524
<210> 218
<211> 1487
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_dolichum
<220>
<221> misc_feature
<222> (1)..(1)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (183)..(183)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (348)..(348)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (932)..(932)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (936)..(936)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (971)..(971)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1052)..(1052)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1388)..(1388)
<223> n is a, c, g, or t
<400> 218
ncaaatggag agtttgatcc tggctcagga tgaacgctgg cggcatgcct aatacatgca 60
agtcgaacga agtttttagg aaagcttgct ttccaaaaag acttagtggc gaacgggtga 120
gtaacacgta gataacctgc ccatgtgccc gggataactg ctggaaacgg tagctaaaac 180
cgnataggtg gcttcgaggc atctcggaga cattaaaatg gctaaggcca tgaacatgga 240
tggatctgcg gcgcattagc tagttggtga ggtaacggcc caccaaggcg acgatgcgta 300
gccgacctga gagggtgaac ggccacattg ggactgagac acggcccnaa ctcctacggg 360
aggcagcagt agggaatttt cgtcaatggg gggaaccctg aacgagcaat gccgcgtgag 420
tgaagaaggt cttcggatcg taaagctctg ttgtaagaga aaaacggatc atgtagggaa 480
tgacatgata gtgatggtat cttaccagaa agccacggct aactacgtgc cagcagccgc 540
ggtaatacgt aggtggcaag cgttatccgg aatgattggg cgtaaagggt gcgtaggtgg 600
tacattaagt ctgaagtaaa aggcagcagc tcaactgctg ttcgctttgg aaactggtga 660
actagagtgc aggagagggc gatggaattc catgtgtagc ggtaaaatgc gtagatatat 720
ggaggaacac cagtggcgaa ggcggtcgcc tggcctgtaa ctgacactga ggcacgaaag 780
cgtggggagc aaataggatt agatacccta gtagtccacg ccgtaaacga tgagaactaa 840
gtgttggaga gattcagtgc tgcagttaac gcaataagtt ctccgcctgg ggagtatgca 900
cgcaagtgtg aaactcaaag gaattgacgg gngccngcac aagcggtgga gtatgtggtt 960
taattcgaag naacgcgaag aaccttacca ggccttgaca tggatataaa tgttctagag 1020
atagaaagat agctatatat cacacaggtg gngcatggtt gtcgtcagct cgtgtcgtga 1080
gatgttgggt taagtcccgc aacgagcgca acccttgtcg catgttacca atattaagtt 1140
agggactcat gtgagactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca 1200
tcatgcccct tatggcctgg gctacacacg tactacaatg gcgtctacaa agaggagcga 1260
catggtgaca tgaagcaaat ctcataaagg gcgtctcagt tcggattgga gtctgcaact 1320
cgactccatg aagtcggaat cgctagtaat cgcagatcag catgctgcgg tgaatacgtt 1380
ctcgggcntt gtacacaccg cccgtcaaac catgggagtc agtaataccc gaagccggtg 1440
gcataaccta agggagtgag ccgtcgaagg taggaccgat gactggg 1487
<210> 219
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_fissicatena
<220>
<221> misc_feature
<222> (238)..(239)
<223> n is a, c, g, or t
<400> 219
tttgatcctg gctcaggatg aacgctggcg gcgtgcttaa cacatgcaag tcgagcgaag 60
cactttactt tgatttcttc ggaatgaaga gtgttgtgac tgagcggcgg acgggtgagt 120
aacgcgtggg taacctgcct catacagggg gataacagtt agaaatgact gctaataccg 180
cataagacca cagtaccgca tggtacagtg ggaaaaactc cggtggtatg agatggannc 240
brcccgcgtc tgattagcta gttggtaagg taacggctta ccaaggcgac gatcagtagc 300
cgacctgaga gggtgaccgg ccacattggg actgagacac ggcccaaact cctacgggag 360
gcagcagtgg ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgaagg 420
atgaagtatt tcggtatgta aacttctatc agcagggaag aaaatgacgg tacctgacta 480
agaagccccg gctaactacg tgccagcagc cgcggtaata cgtagggggc aagcgttatc 540
cggatttact gggtgtaaag ggagcgtaga cggttatgta agtctgatgt gaaaacccgg 600
ggctcaaccc cgggactgca ttggaaacta tgtaactaga gtgtcggaga ggtaagtgga 660
attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaaggcggc 720
ttactggacg atcactgacg ttgaggctcg aaagcgtggg gagcaaacag gattagatac 780
cctggtagtc cacgccgtaa acgatgaata ctaggtgtcg ggtggcaaag ccattcggtg 840
ccgcagcaaa cgcaataagt attccacctg gggagtacgt tcgcaagaat gaaactcaaa 900
ggaattgacg gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc tgctcttgac atcccactga ccggcacgta atggtgcctt cccttcgggg 1020
cagtggagac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaaccct tatctttagt agccagcggt ttggccgggc actctagaga 1140
gactgccagg gataacctgg aggaaggtgg ggatgacgtc aaatcatcat gccccttatg 1200
agcagggcta cacacgtgct acaatggcgt aaacaaaggg aggcaatacc gcgaggttga 1260
gcaaatccca aaaataacgt ctcagttcgg attgtagtct gcaactcgac tacatgaagc 1320
tggaatcgct agtaatcgcg aatcagaatg tcgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagttggta acgcccgaag tcagtgaccc aaccgtaagg 1440
agggagctgc cgaaggcggg atcgataact ggggtgaagt cgtaacaagg tagccgtatc 1500
ggaaggtgcg gctggatcac ctccttt 1527
<210> 220
<211> 1431
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_hallii
<400> 220
ggtgactgag tggcggacgg gtgagtaacg cgtgggtaac ctgccctgta cagggggata 60
acagctggaa acggctgcta ataccgcata agcgcacgag gagacatctc cttgtgtgaa 120
aaactccggt ggtacaggat gggcccgcgt ctgattagct ggttggcagg gtaacggcct 180
accaaggcaa cgatcagtag ccggtctgag aggatgaacg gccacattgg aactgagaca 240
cggtccaaac tcctacggga ggcagcagtg gggaatattg cacaatgggg gaaaccctga 300
tgcagcaacg ccgcgtgagt gaagaagtat ttcggtatgt aaagctctat cagcagggaa 360
gataatgacg gtacctgact aagaagctcc ggctaaatac gtgccagcag ccgcggtaat 420
acgtatggag caagcgttat ccggatttac tgggtgtaaa gggtgcgtag gtggcagtgc 480
aagtcagatg tgaaaggccg gggctcaacc ccggagctgc atttgaaact gctcggctag 540
agtacaggag aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg 600
aacaccagtg gcgaaggcgg cctgctggac tgttactgac actgaggcac gaaagcgtgg 660
ggagcaaaca ggattagata ccctggtagt ccacgccgta aacgatgaat actaggtgtc 720
ggggccgtat aggcttcggt gccgccgcta acgcagtaag tattccacct ggggagtacg 780
ttcgcaagaa tgaaactcaa aggaattgac ggggacccgc acaagcggtg gagcatgtgg 840
tttaattcga agcaacgcga agaaccttac caggtcttga catccttctg accgcacctt 900
aatcggtgct ttccttcggg acagaagaga caggtggtgc atggttgtcg tcagctcgtg 960
tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc ctatcttcag tagccagcag 1020
gtaaggctgg gcactctgga gagactgcca gggataacct ggaggaaggt ggggacgacg 1080
tcaaatcatc atgcccctta tgatctgggc gacacacgtg ctacaatggc ggtcacagag 1140
tgaggcgaac ccgcgagggg gagcaaacca caaaaaggcc gtcccagttc ggactgtagt 1200
ctgcaacccg actacacgaa gctggaatcg ctagtaatcg cgaatcagaa tgtcgcggtg 1260
aatacgttcc cgggtcttgt acacaccgcc cgtcacacca tgggagtcgg aaatgcccga 1320
agccagtgac ccaacctttt ggagggagct gtcgaaggtg gagccggtaa ctggggtgaa 1380
gtcgtaacaa ggtagccgta tcggaaggtg cggctggatc acctcctttc t 1431
<210> 221
<211> 1473
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_hallii
<220>
<221> misc_feature
<222> (611)..(611)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (949)..(949)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1081)..(1081)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1092)..(1092)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1178)..(1179)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1221)..(1221)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1253)..(1253)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1263)..(1263)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1368)..(1369)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1385)..(1385)
<223> n is a, c, g, or t
<400> 221
tgagagtttg atcctggctc aggatgaacg ctggcggcgt gcctaacaca tgcaagtcga 60
acgaagcacc ttaccwgatt cttcggatga aagwytggtg actgagtggc ggacgggtga 120
gtaacgcgtg ggtaacctgc cctgtacagg gggataacag ctggaaacgg ctgctaatac 180
cgcataagcg cacgaggaga catctccttg tgtgaaaaac tccggtggta caggatgggc 240
ccgcgtctga ttagctggtt ggcagggtaa cggcctacca aggcaacgat cagtagccgg 300
tctgagagga tgaacggcca cattggaact gagacacggt ccaaactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcaacgccgc gtgagtgaag 420
aagtatttcg gtatgtaaag ctctatcagc agggaagata atgacggtac ctgactaaga 480
agctccggct aaatacgtgc cagcagccgc ggtaatacgt atggagcaag cgttatccgg 540
atttactggg tgtaaagggt gcgtaggtgg cagtgcaagt cagatgtgaa aggccggggc 600
tcaaccccgg ngctgcattt gaaactgcwy rgctagagta caggagaggc aggcggaatt 660
cctagtgtag cggtgaaatg cgtagatatt aggaggaaca ccagtggcga aggcggcctg 720
ctggactgtt actgacactg aggcacgaaa gcgtggggag caaacaggat tagataccct 780
ggtagtccac gccgtaaacg atgaatacta ggtgtcgggg ccgtataggc tycggtgccg 840
ccgctaacgc agtaagtatt ccacctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagna acgcgaagaa 960
ccttaccagg tcttgacatc cttctgaccg caccttaatc ggtgctttcc ttcgggacag 1020
aagagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
ncaacgagcg cnacccctat cttcagtagc cagcaggtaa ggctgggcac tctggagaga 1140
ctgccaggga taacctggag gaaggtgggg acgacgtnna atcatcatgc cccttatgat 1200
ctgggcgaca cacgtgctac natggcggtc acagagtgag gcgaaccygc ganggggagc 1260
aanccacaaa aaggccgtcc cagttcggac tgtagtctgc aacccgacta cacgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccnng tcttgtacac 1380
accgnccgtc acaccatggg agtcggaaat gcccgaagcc agtgacccaa cctttatgga 1440
gggagctgtc gaaggtggag ccggtaactg ggg 1473
<210> 222
<211> 1512
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_limosum
<400> 222
agagtttgat cctggctcag gacgaacgct ggcggtatgc ttaacacatg caagtcgaac 60
gagaaggttt tgaatgatcc ttcgggtgaa attagaactg gaaagtggcg aacgggtgag 120
taacgcgtgg gtaacctgcc ctatggaaag gaatagcctc gggaaactgg gagtaaagcc 180
ttatattatg gttttgtcgc atggcgagat catgaaaact ccggtgccat aggatggacc 240
cgcgtcccat tagctagttg gtgagataac agcccaccaa ggcgacgatg ggtaaccggt 300
ctgagagggc gaacggtcac actggaactg agacacggtc cagactccta cgggaggcag 360
cagtggggaa tattgcgcaa tgggggcaac cctgacgcag caataccgcg tgagtgaaga 420
aggttttcgg atcgtaaagc tctgttattg gggaagaaaa catgacggta cccaatgagg 480
aagtcccggc taactacgtg ccagcagccg cggtaatacg taggggacaa gcgttgtccg 540
gaatgactgg gcgtaaaggg cgcgtaggcg gtctattaag tctgatgtga aaggtaccgg 600
ctcaaccggt gaagtgcatt ggaaactggt agacttgagt attggagagg caagtggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
gctggacaaa tactgacgct gaggtgcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgaatgct aggtgttggg gaaactcagt gccgcagtta 840
acacaataag cattccgcct ggggagtacg accgcaaggt tgaaactcaa aggaattgac 900
ggggacccgc acaagcagcg gagcatgtgg tttaattcga agcaacgcga agaaccttac 960
caggtcttga catcctctga cgagcctaga gataggaagt ttccttcggg aacagagaga 1020
caggtggtgc atggttgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1080
agcgcaaccc ctgcctttag ttgccagcat taagttgggc actctagagg gactgccgta 1140
gacaatacgg aggaaggtgg ggatgacgtc aaatcatcat gccccttatg acctgggcta 1200
cacacgtgct acaatggtct gaacagaggg ccgcgaagcc gcgaggtgaa gcaaatccct 1260
taaaacagat cccagttcgg attgcaggct gcaactcgcc tgcatgaagt tggagttgct 1320
agtaatcgcg gatcagaatg ccgcggtgaa tgcgttcccg ggtcttgtac acaccgcccg 1380
tcacaccacg agagttggca acacccgaag cctgtgagag aaccgcaagg actcagcagt 1440
cgaaggtggg gctagtaatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg 1500
gctggatcac ct 1512
<210> 223
<211> 1521
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_rectale
<400> 223
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gaagcacttt atttgatttc cttcgggact gattattttg tgactgagtg gcggacgggt 120
gagtaacgcg tgggtaacct gccttgtaca gggggataac agttggaaac ggctgctaat 180
accgcataag cgcacagcat cgcatgatgc agtgtgaaaa actccggtgg tataagatgg 240
acccgcgttg gattagctag ttggtgaggt aacggcccac caaggcgacg atccatagcc 300
gacctgagag ggtgaccggc cacattggga ctgagacacg gcccaaactc ctacgggagg 360
cagcagtggg gaatattgca caatgggcga aagcctgatg cagcgacgcc gcgtgagcga 420
agaagtattt cggtatgtaa agctctatca gcagggaaga taatgacggt acctgactaa 480
gaagcaccgg ctaaatacgt gccagcagcc gcggtaatac gtatggtgca agcgttatcc 540
ggatttactg ggtgtaaagg gagcgcaggc ggtgcggcaa gtctgatgtg aaagcccggg 600
gctcaacccc ggtactgcat tggaaactgt cgtactagag tgtcggaggg gtaagcggaa 660
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 720
tactggacga taactgacgc tgaggctcga aagcgtgggg agcaaacagg attagatacc 780
ctggtagtcc acgctgtaaa cgatgaatac taggtgttgg gaagcattgc ttctcggtgc 840
cgtcgcaaac gcagtaagta ttccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tccttctgac cggtacttaa ccgtaccttc tcttcggagc 1020
aggagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctt atctttagta gccagcggtc tggccgggca ctctagagag 1140
actgccaggg ataacctgga ggaaggcggg gatgacgtca aatcatcatg ccccttatga 1200
cttgggctac acacgtgcta caatggcgta aacaaaggga agcgaagctg tgaagccgag 1260
caaatctcaa aaataacgtc tcagttcgga ctgtagtctg caacccgact acacgaagct 1320
ggaatcgcta gtaatcgcag atcagaatgc tgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagttgggaa tgcccgaagc cagtgaccta accgaaagga 1440
aggagctgtc gaaggcaggc tcgataactg gggtgaagtc gtaacaaggt agccgtatcg 1500
gaaggtgcgg ctggatcacc t 1521
<210> 224
<211> 1537
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_rectale
<400> 224
tttaacatga gagtttgatc ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg aagcacttta tttgatttcc ttcgggactg attattttgt gactgagtgg 120
cggacgggtg agtaacgcgt gggtaacctg ccttgtacag ggggataaca gttggaaacg 180
gctgctaata ccgcataagc gcacagcatc gcatgatgca gtgtgaaaaa ctccggtggt 240
ataagatgga cccgcgttgg attagctagt tggtgaggta acggcccacc aaggcgacga 300
tccatagccg acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc 360
tacgggaggc agcagtgggg aatattgcac aatgggcgaa agcctgatgc agcgacgccg 420
cgtgagcgaa gaagtatttc ggtatgtaaa gctctatcag cagggaagat aatgacggta 480
cctgactaag aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa 540
gcgttatccg gatttactgg gtgtaaaggg agcgcaggcg gtgcggcaag tctgatgtga 600
aagcccgggg ctcaaccccg gtactgcatt ggaaactgtc gtactagagt gtcggagggg 660
taagcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 720
aaggcggctt actggacgat aactgacgct gaggctcgaa agcgtgggga gcaaacagga 780
ttagataccc tggtagtcca cgccgtaaac gatgaatact aggtgttggg aagcattgct 840
tctcggtgcc gtcgcaaacg cagtaagtat tccacctggg gagtacgttc gcaagaatga 900
aactcaaagg aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc 960
aacgcgaaga accttaccaa gtcttgacat ccttctgacc ggtacttaac cgtaccttct 1020
cttcggagca ggagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg 1080
ggttaagtcc cgcaacgagc gcaaccctta tctttagtag ccagcggttc ggccgggcac 1140
tctagagaga ctgccaggga taacctggag gaaggcgggg atgacgtcaa atcatcatgc 1200
cccttatgac ttgggctaca cacgtgctac aatggcgtaa acaaagggaa gcaaagctgt 1260
gaagccgagc aaatctcaaa aataacgtct cagttcggac tgtagtctgc aacccgacta 1320
cacgaagctg gaatcgctag taatcgcaga tcagaatgct gcggtgaata cgttcccggg 1380
tcttgtacac accgcccgtc acaccatggg agttgggaat gcccgaagcc agtgacctaa 1440
ccgaaaggaa ggagctgtcg aaggcaggct cgataactgg ggtgaagtcg taacaaggta 1500
gccgtatcgg aaggtgcggc tggatcacct cctttct 1537
<210> 225
<211> 1521
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_rectale
<400> 225
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gaagcacttt atttgatttc cttcgggact gattattttg tgactgagtg gcggacgggt 120
gagtaacgcg tgggtaacct gccttgtaca gggggataac agttggaaac ggctgctaat 180
accgcataag cgcacagcat cgcatgatgc agtgtgaaaa actccggtgg tataagatgg 240
acccgcgttg gattagctag ttggtgaggt aacggcccac caaggcgacg atccatagcc 300
gacctgagag ggtgaccggc cacattggga ctgagacacg gcccaaactc ctacgggagg 360
cagcagtggg gaatattgca caatgggcga aagcctgatg cagcgacgcc gcgtgagcga 420
agaagtattt cggtatgtaa agctctatca gcagggaaga taatgacggt acctgactaa 480
gaagcaccgg ctaaatacgt gccagcagcc gcggtaatac gtatggtgca agcgttatcc 540
ggatttactg ggtgtaaagg gagcgcaggc ggtgcggcaa gtctgatgtg aaagcccggg 600
gctcaacccc ggtactgcat tggaaactgt cgtactagag tgtcggaggg gtaagcggaa 660
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 720
tactggacga taactgacgc tgaggctcga aagcgtgggg agcaaacagg attagatacc 780
ctggtagtcc acgccgtaaa cgatgaatac taggtgttgg gaagcattgc ttctcggtgc 840
cgtcgcaaac gcagtaagta ttccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tccttctgac cggtacttaa ccgtaccttc tcttcggagc 1020
aggagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctt atctttagta gccagcggtt cggccgggca ctctagagag 1140
actgccaggg ataacctgga ggaaggcggg gatgacgtca aatcatcatg ccccttatga 1200
cttgggctac acacgtgcta caatggcgta aacaaaggga agcaaagctg tgaagccgag 1260
caaatctcaa aaataacgtc tcagttcgga ctgtagtctg caacccgact acacgaagct 1320
ggaatcgcta gtaatcgcag atcagaatgc tgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagttgggaa tgcccgaagc cagtgaccta accgaaagga 1440
aggagctgtc gaaggcaggc tcgataactg gggtgaagtc gtaacaaggt agccgtatcg 1500
gaaggtgcgg ctggatcacc t 1521
<210> 226
<211> 1496
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_rectale
<400> 226
agtttgatcc tggctcagga tgaacgctgg cggcgtgctt aacacatgca agtcgaacga 60
aggcacttct atatgatttc cttcgggact gattattttg tgactgagtg gcggacgggt 120
gagtaacgcg tgggtaacct gccttgtaca gggggataac agttggaaac ggctgctaat 180
accgcataag cgcacggcat cgcatgatgc agtgtgaaaa actccggtgg tataagatgg 240
acccgcgttg gattagctag ttggtgaggt aacggcccac caaggcgacg atccatagcc 300
gacctgagag ggtgaccggc cacattggga ctgagacacg gcccaaactc ctacgggagg 360
cagcagtggg gaatattgca caatgggcga aagcctgatg cagcgacgcc gcgtgagcga 420
agaagtattt cggtatgtaa agctctatca gcagggaaga taatgacggt acctgactaa 480
gaagcaccgg ctaaatacgt gccagcagcc gcggtaatac gtatggtgca agcgttatcc 540
ggatttactg ggtgtaaagg gagcgcaggc ggtgcggcaa gtctgatgtg aaagcccggg 600
gctcaacccc ggtactgcat tggaaactgt cgtactagag tgtcggaggg gtaagcggaa 660
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 720
tactggacga taactgacgc tgaggctcga aagcgtgggg agcaaacagg attagatacc 780
ctggtagtcc acgccgtaaa cgatgaatac taggtgttgg gaagcattgc ttctcggtgc 840
cgtcgcaaac gcagtaagta ttccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tccttctgac cggtacttaa ccgtaccttc tcttcggagc 1020
aggagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctt atctttagta gccagcggtt cggccgggca ctctagagag 1140
actgccaggg ataacctgga ggaaggcggg gatgacgtca aatcatcatg ccccttatga 1200
cttgggctac acacgtgcta caatggcgta aacaaaggga agcaaagctg tgaagccgag 1260
caaatctcaa aaataacgtc tcagttcgga ctgtagtctg caacccgact acacgaagct 1320
ggaatcgcta gtaatcgcag atcagaatgc tgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagttgggaa tgcccgaagc cagtgaccta accgaaagga 1440
aggagctgtc gaaggcaggc tcgataactg gggtgaagtc gtaacaaggt agccgt 1496
<210> 227
<211> 1526
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_sp_3_1_31
<400> 227
agagtttgat cctggctcag gatgaacgct ggcggcatgc ctaatacatg caagtcgaac 60
gaagtcttta ggaagcttgc ttccaaagag acttagtggc gaacgggtga gtaacacgta 120
ggtaacctgc ccatgtgccc gggataactg ctggaaacgg tagctaaaac cggataggta 180
tgagggaggc atcttcctca tattaaagca ccttcgggtg tgaacatgga tggacctgcg 240
gcgcattagc tggttggtga ggtaacggcc caccaaggcg atgatgcgta gccgacctga 300
gagggtgaac ggccacattg ggactgagac acggcccaaa ctcctacggg aggcagcagt 360
agggaatttt cgtcaatggg gggaaccctg aacgagcaat gccgcgtgtg tgaagaaggt 420
cttcggatcg taaagcactg ttgtaagtga agaatgccac atagaggaaa tgctatgtgg 480
gtgacggtag cttaccagaa agccacggct aactacgtgc cagcagccgc ggtaatacgt 540
aggtggcaag cgttatccgg aatcattggg cgtaaagggt gcgtaggtgg cacgataagt 600
ctgaagtaaa aggcaacagc tcaactgttg tatgctttgg aaactgtcga gctagagtgc 660
agaagagggc gatggaattc catgtgtagc ggtaaaatgc gtagatatat ggaggaacac 720
cagtggcgaa ggcggtcgcc tggtctgtaa ctgacactga tgcacgaaag cgtggggagc 780
aaataggatt agatacccta gtagtccacg ccgtaaacga tgagaactaa gtgttggaga 840
gattcagtgc tgcagttaac gcaataagtt ctccgcctgg ggagtatgca cgcaagtgtg 900
aaactcaaag gaattgacgg gggcccgcac aagcggtgga gtatgtggtt taattcgaag 960
caacgcgaag aaccttacca ggccttgaca tggatataaa tgttctagag atagaaagat 1020
agctatatat cacacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 1080
taagtcccgc aacgagcgca acccttgtct tctgttacca gcattaagtt ggggactcag 1140
gagagactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 1200
tatggcctgg gctacacacg tactacaatg gcgcctacaa agagcagcga caccgcgagg 1260
tgaagcgaat ctcataaagg gcgtctcagt tcggattgaa gtctgcaact cgacttcatg 1320
aagtcggaat cgctagtaat cgcagatcag catgctgcgg tgaatacgtt ctcgggcctt 1380
gtacacaccg cccgtcaaac catgggagtt ggtaataccc gaagccggtg gcataaccgc 1440
aaggagtgag ccgtcgaagg taggaccgat gactggggtt aagtcgtaac aaggtatccc 1500
tacgggaacg tggggatgga tcacct 1526
<210> 228
<211> 1363
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_sp_oral_clone_GI038
<400> 228
gagtttgatt ctggctcagg atgaacgctg gcggcgtgcc taacacatgc aagtcgaacg 60
agtggcggac gggtgagtaa cgcgtgggca acctgcccca taccggggga tagcagttgg 120
aaacggctgg taaaaccgca taagaaaaag tggtatggga tgggcccgcg tctgattagc 180
cagttggtga ggtaacggct caccaaagcg acgatcagta gccggcctga gagggcggac 240
ggccacattg ggactgagac acggcccaga ctcctacggg aggcagcagt gggggatatt 300
gcacaatgga ggaaactctg atgcagcgac gccgcgtgag tgaagaagta tttcggtatg 360
taaagctcta tcagcaggga agatgacggt acctgagtaa gaagctccgg ctaaatacgt 420
gccagcagcc gcggtaatac gtatggagca agcgttatcc ggatttactg ggtgtaaagg 480
gagcgcagac ggatatgcaa gtctgaagtg aaaccccacg gctcaaccgt gggcttgctt 540
tggaaactgt agatctagag tactggagag gtaagcggaa ttcctggtgt agcggtgaaa 600
tgcgtagata tcaggaagaa catcggcggc gaaggcggct tactggacag actgacgttg 660
aggctcgaag gcgtggggag caaacaggat tagataccct ggtagcccac gcggtaaacg 720
atgaatacta ggtgttggga tttcagtgcc gaagcaaacg tgataagtat tccacctggg 780
gagtacgttc gcaagaatga aactcaaagg aattgacggg gacccgcaca agcggtggag 840
catgtggttt aattcgaagc aacgcgaaga accttaccag accttgaatc gacaggtggt 900
gcatggttgt cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac 960
ccttgcgtat agtagccagc aattgggaac tctatacgga ctgccgggga taacccggag 1020
gaaggtgggg atgacgtcaa atcatcatgc cccttatggt ctgggctaca cacgtgctac 1080
aatgtcgcag agggaagcga aagggtgacc tgaagcgaat ctcaaaacga cccagttcgg 1140
atgcaggctg caacccgcct gcagaagctg gaatcgctag taatcgcgaa tcagcatgtc 1200
gcggtgaata cgttcccggg tcttgtacac accgcccgtc acaccatggg agtcgggaat 1260
gcccgaagcc ggtacctaag gagccgtcga aggcaggccg gatgactggg gtgaagtcgt 1320
aacaaggtag ccgtaggaga acctgcggct ggaacacctc ctt 1363
<210> 229
<211> 1492
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_sp_WAL_14571
<400> 229
tagaagtttg tatttctgct caggatgacg ctggcggcgt gcttaacaca tgcaagttcg 60
agcgagaagc ccattgactg aaaccttccg gtagaaggga ttatggtgga aagcggcgga 120
cggggtgagt aacgcgtagc caacttgccc tttacagagg gatagccatt ggaaacgatg 180
attaaaacct cataacgctc ccccycacat ggaggggaag ccaaagattc atcggtaagg 240
gatgggcctg cgtctgatta gcttgttggc ggggtaacgg cccaccaagg cgacgatcag 300
tagccgacct gagagggtga tcggccacat tggaactgag acacggtcca aactcctacg 360
ggaggcagca gtggggaata ttgcacaatg ggcgaaagcc tgatgcagca acgccgcgtg 420
agggatgaag gccttcgggt cgtaaacctc tgtccttggg gaagaaacaa atgacggtac 480
ccatggagga agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggcgag 540
cgttatccgg aattattggg cgtaaagagt gcgtaggtgg ttacctaagc gcagggtcta 600
aggcaatggc tcaaccattg ttcgccctgc gaactgggct acttgagtgc aggagaggaa 660
agcggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa 720
ggcggctttc tggactgtta ctgacactga ggcacgaaag cgtggggagc aaacaggatt 780
agataccctg gtagtccacg ccgtaaacga tgagcactag gtgtcggggc cgcaaggctt 840
cggtgccgca gttaacgcat taagtgctcc gcctggggag tacgcacgca agtgtgaaac 900
tcaaaggaat tgacggggac ccgcacaagc agcggagcat gtggtttaat tcgaagcaac 960
gcgaagaacc ttaccaggac ttgacatccc actgacagat ccctaaccgg atccttcttc 1020
ggacagtgga gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga tgttgggtta 1080
agtcccgcaa cgagcgcaac ccttgccatt agttgccatc attcagttgg gcactctaat 1140
gggactgccg gggacaactc ggaggaaggt ggggatgacg tcaaatcatc atgcccctta 1200
tgttctgggc tacacacgtg ctacaatggc cggtacagca agaagcaaaa ccgcgaggtg 1260
gagcaaatct caaaaaccgg tcccagttcg gactgcaggc tgaaacccgc ctgcacgaag 1320
ccggagttgc tagtaatcgt ggatcagaat gccacggtga atgcgttccc gggtcttgta 1380
cacaccgccc gtcacaccat ggaagttggg ggtgcccgaa gccggcaggg aaatatgctg 1440
tctaaggcaa aaccaatgac tggggtgaag tcgtaacaag gttaaccgta aa 1492
<210> 230
<211> 1509
<212> DNA
<213> Artificial Sequence
<220>
<223> Eubacterium_tenue
<220>
<221> misc_feature
<222> (33)..(33)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (70)..(88)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (177)..(177)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (511)..(512)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1450)..(1450)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1455)..(1461)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1470)..(1475)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1486)..(1494)
<223> n is a, c, g, or t
<400> 230
ttttatttga gagtttgatc ctggctcagg atnaacgctg gcggcgtgcc taacacatgc 60
aagtcgagcn nnnnnnnnnn nnnnnnnnag cggcggacgg gtgagtaacg cgtgggtaac 120
ctgccctgta cacacggata acataccgaa aggtatgcta atacgagatg atatatnaaa 180
gttgcatgac ttttatatca aagcttttgc ggtacaggat ggacccgcgt ctgattagct 240
agttggtaag gtaacggctt accaaggcga cgatcagtag ccgacctgag agggtgatcg 300
gccacactgg aactgagaca cggtccagac tcctacggga ggcagcagtg gggaatattg 360
cacaatgggc gaaagcctga tgcagcaacg ccgcgtgagc gatgaaggcc ttcgggtcgt 420
aaagctctgt cctcaaggaa gataatgacg gtacttgagg aggaagcccc ggctaactac 480
gtgccagcag ccgcggtaat acgtaggggg nnagcgttat ccggaattac tgggcgtaaa 540
gggtgcgtag gcggtctttc aagccagaag tgaaaggcta cggctcaacc gtagtaagct 600
tttggaactg taagacttga gtgcaggaga ggagagtgga attcctagtg tagcggtgaa 660
atgcgtagat attaggagga acaccagtag cgaaggcggc tctctggact gtaactgacg 720
ctgaggcacg aaagcgtggg gagcaaacag gattagatac cctggtagtc cacgccgtaa 780
acgatgagta ctaggtgtcg ggggttaccc ccctcggtgc cgcagctaac gcattaagta 840
ctccgcctgg gaagtacgct cgcaagagtg aaactcaaag gaattgacgg ggacccgcac 900
aagtagcgga gcatgtggtt taattcgaag caacgcgaag aaccttacct aagcttgaca 960
tcccattgac ctctccctaa tcggagattt cccttcgggg acagtggtga caggtggtgc 1020
atggttgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc 1080
ttgcctttag ttgccagcat taagttgggc actctagagg gactgccgag gataactcgg 1140
aggaaggtgg ggatgacgtc aaatcatcat gccccttatg cttagggcta cacacgtgct 1200
acaatgggtg gtacagaggg ttgccaaacc gtgaggtgga gctaatccct taaagccatt 1260
ctcagttcgg attgtaggct gaaactcgcc tacatgaagc tggagttact agtaatcgca 1320
gatcagaatg ctgcggtgaa tgcgttcccg ggtcttgtac acaccgcccg tcacaccatg 1380
ggagttgggg gcgcccgaag ccggttagct aaccttttgg aagcggccgt cgaaggtgaa 1440
accaatgacn ggggnnnnnn ngtaacaagn nnnnngtatc ggaagnnnnn nnnngatcac 1500
ctcctttct 1509
<210> 231
<211> 1505
<212> DNA
<213> Artificial Sequence
<220>
<223> Facklamia_hominis
<220>
<221> misc_feature
<222> (344)..(344)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (364)..(365)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (638)..(638)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (652)..(652)
<223> n is a, c, g, or t
<400> 231
cgaacgctgg cggcgtgcct aatacatgca agtcgaacga acggagctag gaactgaacc 60
cggcaaagtt agtggcgcac gggtgagtaa cacgtggaga acctaccctt ttgcggggga 120
taaccattgg aaacgatgac taataccgca tagaatcgca gatcgcatga tcaacgaagg 180
aaagacggct tcggctgtcg caaaaggatg gctccgcggt gcattagcta gatggtgggg 240
taacggccta ccatggcaat gatgcatagc cgacctgaga gggtgatcgg ccacattggg 300
actgagacac ggcccaaact cctacgggag gcagcagtag ggantcttcc gcaatgggcg 360
caannctgac ggagcaacgc cgcgtgtgtg aagaaggtct tcggatcgta aagcactgtt 420
gttagagaag aacgaccgct agagtaactg ttagcggagt gacggtatct aaccagaaag 480
ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg ttgtccggat 540
ttattgggcg taaagggagc gcaggcggtg acttaagtct gatgtgaaag cccacggctc 600
aaccgtggag ggtcattgga aactgggtca cttgagtnca gaagaggaaa gnggaattcc 660
atgtgtagcg gtgaaatgcg tagatatatg gaggaacacc agtggcgaag gcgactttct 720
ggtctgtaac tgacgctgag gctcgaaagc gtggggagca aacaggatta gataccctgg 780
tagtccacgc cgtaaacgat gagtgctaag tgttggaggg tttccaccct tcagtgctgg 840
agttaacgca ataagcactc cgcctgggga gtacggccgc aaggctgaaa ctcaaaggaa 900
ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac 960
cttaccaggt cttgacatct cttgcatagc ctagagatag gtgaagccct tcggggcaag 1020
aagacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 1080
aacgagcgca acccttatca ctagttgcca gcattcagat ggggactcta gtgagactgc 1140
cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 1200
gctacacacg tgctacaatg gatggtacaa cgagcagcga actcgcaagg gcaagcgaat 1260
ctcttaaagc cattctcagt tcggattgtt ctctgcaact cgagaacatg aagccggaat 1320
cgctagtaat cgcggatcag cacgccgcgg tgaatacgtt cccgggtctt gtacacaccg 1380
cccgtcacac cacgagagtt tgtaacaccc gaagccggtg gcctaacttt atgaagccgt 1440
cgaaggtggg acagatgatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg 1500
gctgg 1505
<210> 232
<211> 1465
<212> DNA
<213> Artificial Sequence
<220>
<223> Flavonifractor_plautii
<400> 232
cgctggcggc gtgcttaaca catgcaagtc gaacggggtg ctcatgacgg aggattcgtc 60
caatggattg agttacctag tggcggacgg gtgagtaacg cgtgaggaac ctgccttgga 120
gaggggaata acactccgaa aggagtgcta ataccgcatg aagcagttgg gtcgcatggc 180
tctgactgcc aaagatttat cgctctgaga tggcctcgcg tctgattagc tagtaggcgg 240
ggtaacggcc cacctaggcg acgatcagta gccggactga gaggttgacc ggccacattg 300
ggactgagac acggcccaga ctcctacggg aggcagcagt ggggaatatt gggcaatggg 360
cgcaagcctg acccagcaac gccgcgtgaa ggaagaaggc tttcgggttg taaacttctt 420
ttgtcgggga cgaaacaaat gacggtaccc gacgaataag ccacggctaa ctacgtgcca 480
gcagccgcgg taatacgtag gtggcaagcg ttatccggat ttactgggtg taaagggcgt 540
gtaggcggga ttgcaagtca gatgtgaaaa ctgggggctc aacctccagc ctgcatttga 600
aactgtagtt cttgagtgct ggagaggcaa tcggaattcc gtgtgtagcg gtgaaatgcg 660
tagatatacg gaggaacacc agtggcgaag gcggattgct ggacagtaac tgacgctgag 720
gcgcgaaagc gtggggagca aacaggatta gataccctgg tagtccacgc cgtaaacgat 780
ggatactagg tgtggggggt ctgaccccct ccgtgccgca gttaacacaa taagtatccc 840
acctggggag tacgatcgca aggttgaaac tcaaaggaat tgacgggggc ccgcacaagc 900
ggtggagtat gtggtttaat tcgaagcaac gcgaagaacc ttaccagggc ttgacatccc 960
actaacgagg cagagatgcg ttaggtgccc ttcggggaaa gtggagacag gtggtgcatg 1020
gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaaccctta 1080
ttgttagttg ctacgcaaga gcactctagc gagactgccg ttgacaaaac ggaggaaggt 1140
ggggacgacg tcaaatcatc atgcccctta tgtcctgggc cacacacgta ctacaatggt 1200
ggttaacaga gggaggcaat accgcgaggt ggagcaaatc cctaaaagcc atcccagttc 1260
ggattgcagg ctgaaacccg cctgtatgaa gttggaatcg ctagtaatcg cggatcagca 1320
tgccgcggtg aatacgttcc cgggccttgt acacaccgcc cgtcacacca tgagagtcgg 1380
gaacacccga agtccgtagc ctaaccgcaa ggagggcgcg gccgaaggtg ggttcgataa 1440
ttggggtgaa gtcgtaacaa ggtag 1465
<210> 233
<211> 1460
<212> DNA
<213> Artificial Sequence
<220>
<223> Flavonifractor_plautii
<400> 233
gcgtgcttaa cacatgcaag tcgaacgggg tgctcatgac ggaggattcg tccaacggat 60
tgagttacct agtggcggac gggtgagtaa cgcgtgagga acctgccttg gagaggggaa 120
taacactccg aaaggagtgc taataccgca tgatgcagtt gggtcgcatg gctctgactg 180
ccaaagattt atcgctctga gatggcctcg cgtctgatta gctagtaggc ggggtaacgg 240
cccacctagg cgacgatcag tagccggact gagaggttga ccggccacat tgggactgag 300
acacggccca gactcctacg ggaggcagca gtggggaata ttgggcaatg ggcgcaagcc 360
tgacccagca acgccgcgtg aaggaagaag gctttcgggt tgtaaacttc ttttgtcggg 420
gacgaaacaa atgacggtac ccgacgaata agccacggct aactacgtgc cagcagccgc 480
ggtaatacgt aggtggcaag cgttatccgg atttactggg tgtaaagggc gtgtaggcgg 540
gattgcaagt cagatgtgaa aactgggggc tcaacctcca gcctgcattt gaaactgtag 600
ttcttgagtg ctggagaggc aatcggaatt ccgtgtgtag cggtgaaatg cgtagatata 660
cggaggaaca ccagtggcga aggcggattg ctggacagta actgacgctg aggcgcgaaa 720
gcgtggggag caaacaggat tagataccct ggtagtccac gccgtaaacg atggatacta 780
ggtgtggggg gtctgacccc ctccgtgccg cagttaacac aataagtatc ccacctgggg 840
agtacgatcg caaggttgaa actcaaagga attgacgggg gcccgcacaa gcggtggagt 900
atgtggttta attcgaagca acgcgaagaa ccttaccagg gcttgacatc ccactaacga 960
agcagagatg cattaggtgc ccttcgggga aagtggagac aggtggtgca tggttgtcgt 1020
cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tattgttagt 1080
tgctacgcaa gagcactcta gcgagactgc cgttgacaaa acggaggaag gtggggacga 1140
cgtcaaatca tcatgcccct tatgtcctgg gccacacacg tactacaatg gtggttaaca 1200
gagggaggca ataccgcgag gtggagcaaa tccctaaaag ccatcccagt tcggattgca 1260
ggctgaaacc cgcctgtatg aagttggaat cgctagtaat cgcggatcag catgccgcgg 1320
tgaatacgtt cccgggcctt gtacacaccg cccgtcacac catgagagtc gggaacaccc 1380
gaagtccgta gcctaaccgc aaggagggcg cggccgaagg tgggttcgat aattggggtg 1440
aagtcgtaac aaggtagccg 1460
<210> 234
<211> 1535
<212> DNA
<213> Artificial Sequence
<220>
<223> Gardnerella_vaginalis
<400> 234
ttttcgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatctgacc agcttgctgg ttggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccaac ctgccccatg ctccagaata gctcttggaa acgggtggta atgctggatg 180
ctccaacttg acgcatgtct tgttgggaaa gtgtttagtg gcatgggatg gggtcgcgtc 240
ctatcagctt gtaggcgggg taatggccca cctaggcttc gacgggtagc cggcctgaga 300
gggcggacgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc gcaatggggg aaaccctgac gcagcgacgc cgcgtgcggg atgaaggcct 420
tcgggttgta aaccgctttt gattgggagc aagctttcgg gtgagtgtac ctttcgaata 480
agcgccggct aactacgtgc cagcagccgc ggtaatacgt agggcgcaag cgttatccgg 540
aattattggg cgtaaagagc ttgtaggcgg ttcgtcgcgt ctggtgtgaa agcccatcgc 600
ttaacggtgg gtctgcgccg ggtacgggcg ggctagagtg cagtagggga gactggaatt 660
cccggtgtaa cggtggaatg tgtagatatc gggaagaaca ccaatggcga aggcaggtct 720
ctgggctgtt actgacgctg agaagcgaaa gcgtggggag cgaacaggat tagataccct 780
ggtagtccac gccgtaaacg gtggacgctg gatgtggggc ccattccacg ggttccgtgt 840
cggagctaac gcgttaagcg tcccgcctgg ggagtacggc cgcaaggcta aaactcaaag 900
aaattgacgg gggcccgcac aagcggcgga gcatgcggat taattcgatg caacgcgaag 960
aaccttacct gggcttgaca tgtgcctgtc gactgcagag atgtggtttc ccttcggggc 1020
aggttcacag gtggtgcatg gtcgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctcg ccctgtgttg ccagcgggtt atgccgggaa ctcacggggg 1140
accgccgggg ttaactcgga ggaaggtggg gatgacgtca gatcatcatg ccccttacgt 1200
ccagggcttc acgcatgcta caatggccgg tacaacggga tgcgacatgg tgacatggag 1260
cggatccctt aaaaccggtc tcagttcgga tcgtagtctg caactcgact acgtgaaggc 1320
ggagtcgcta gtaatcgcga atcagcaacg tcgcggtgaa tgcgttcccg ggccttgtac 1380
acaccgcccg tcaagtcatg aaagtgggca gcacccgaag ccggtggcct aacccttttg 1440
ggatggagcc gtctaaggtg aggctcgtga ttgggactaa gtcgtaacaa ggtagccgta 1500
ccggaaggtg cggctggatc acctcctttc tacgg 1535
<210> 235
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Gardnerella_vaginalis
<400> 235
cgtggagggt tcgattctgg ctcaggatga acgctggcgg cgtgcttaac acatgcaagt 60
cgaacgggat ctagtcagct tgctgactgg tgagagtggc gaacgggtga gtaatgcgtg 120
accaacctgc cccatgctcc agaatagctc ttggaaacgg gtggtaatgc tggatgctcc 180
aacttgacgc atgtcttgtt gggaaagtgt ttagtggcat gggatggggt cgcgtcctat 240
cagcttgtag gcggggtaat ggcccaccta ggcttcgacg ggtagccggc ctgagagggc 300
ggacggccac attgggactg agatacggcc cagactccta cgggaggcag cagtggggaa 360
tattgcgcaa tgggggaaac cctgacgcag cgacgccgcg tgcgggatga aggccttcgg 420
gttgtaaacc gcttttgatt gggagcaagc cttcgggtga gtgtaccttt cgaataagcg 480
ccggctaact acgtgccagc agccgcggta atacgtaggg cgcaagcgtt atccggaatt 540
attgggcgta aagagcttgt aggcggttcg tcgcgtctgg tgtgaaagcc catcgcttaa 600
cggtgggtct gcgccgggta cgggcgggct agagtgcagt aggggagact ggaattcccg 660
gtgtaacggt ggaatgtgta gatatcggga agaacaccaa tggcgaaggc aggtctctgg 720
gctgttactg acgctgagaa gcgaaagcgt ggggagcgaa caggattaga taccctggta 780
gtccacgccg taaacggtgg acgctggatg tggggcccat tccacgggtt ccgtgtcgga 840
gctaacgcgt taagcgtccc gcctggggag tacggccgca aggctaaaac tcaaagaaat 900
tgacgggggc ccgcacaagc ggcggagcat gcggattaat tcgatgcaac gcgaagaacc 960
ttacctgggc ttgacatgtg cctgtcgact gcagagatgt ggtttccctt cggggcaggt 1020
tcacaggtgg tgcatggtcg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 1080
acgagcgcaa ccctcgccct gtgttgccag cgggttatgc cgggaactca cgggggaccg 1140
ccggggttaa ctcggaggaa ggtggggatg acgtcagatc atcatgcccc ttacgtccag 1200
ggcttcacgc atgctacaat ggccggtaca acgggatgcg acatggtgac atggagcgga 1260
tcccttaaaa ccggtctcag ttcggatcgt agtctgcaac tcgactacgt gaaggcggag 1320
tcgctagtaa tcgcgaatca gcaacgtcgc ggtgaatgcg ttcccgggcc ttgtacacac 1380
cgcccgtcaa gtcatgaaag tgggcagcac ccgaagccgg tggcctaacc cttttgggat 1440
ggagccgtct aaggtgaggc tcgtgattgg gactaagtcg taacaaggta gccgtaccgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 236
<211> 1532
<212> DNA
<213> Artificial Sequence
<220>
<223> Gardnerella_vaginalis
<400> 236
ttttcgtgga gggttcgatt ctggctcagg atgaacgctg gcggcgtgct taacacatgc 60
aagtcgaacg ggatctgacc agcttgctgg ttggtgagag tggcgaacgg gtgagtaatg 120
cgtgaccaac ctgccccatg ctccagaata gctcttggaa acgggtggta atgctggatg 180
ctccaacttg acgcatgtct tgttgggaaa gtgtttagtg gcatgggatg gggtcgcgtc 240
ctatcagctt gtaggcgggg taatggccca cctaggcttc gacgggtagc cggcctgaga 300
gggcggacgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgc gcaatggggg aaaccctgac gcagcgacgc cgcgtgcggg atgaaggcct 420
tcgggttgta aaccgctttt gattgggagc aagccttttg ggtgagtgta cctttcgaat 480
aagcgccggc taactacgtg ccagcagccg cggtaatacg tagggcgcaa gcgttatccg 540
gaattattgg gcgtaaagag cttgtaggcg gttcgtcgcg tctggtgtga aagcccatcg 600
cttaacggtg ggtttgcgcc gggtacgggc gggctagagt gcagtagggg agactggaat 660
tctcggtgta acggtggaat gtgtagatat cgggaagaac accaatggcg aaggcaggtc 720
tctgggctgt tactgacgct gagaagcgaa agcgtgggga gcgaacagga ttagataccc 780
tggtagtcca cgccgtaaac ggtggacgct ggatgtgggg cccattccac gggttctgtg 840
tcggagctaa cgcgttaagc gtcccgcctg gggagtacgg ccgcaaggct aaaactcaaa 900
gaaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat gcaacgcgaa 960
gaaccttacc tgggcttgac atgtgcctga cgactgcaga gatgtggttt cctttcgggg 1020
caggttcaca ggtggtgcat ggtcgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctc gccctgtgtt gccagcgggt tatgccggga actcacgggg 1140
gaccgccggg gttaactcgg aggaaggtgg ggatgacgtc agatcatcat gccccttacg 1200
tccagggctt cacgcatgct acaatggcca gtacaacggg ttgcttcatg gtgacatggt 1260
gctaatccct taaaactggt ctcagttcgg atcgtagtct gcaactcgac tacgtgaagg 1320
cggagtcgct agtaatcgcg aatcagcaac gtcgcggtga atgcgttccc gggccttgta 1380
cacaccgccc gtcaagtcat gaaagtgggc agcacccgaa gccggtggcc taaccctttt 1440
gggatggagc cgtctaaggt gaggctcgtg attgggacta agtcgtaaca aggtagccgt 1500
accggaaggt gcggctggat cacctccttt ct 1532
<210> 237
<211> 1315
<212> DNA
<213> Artificial Sequence
<220>
<223> Gardnerella_vaginalis
<400> 237
ccagcttgct ggttggtgag agtggcgaac gggtgagtaa tgcgtgacca acctgcccca 60
tgctccagaa tagctcttgg aaacgggtgg taatgctgga tgctccaact tgacgcatgt 120
cttgttggga aagtgtttag tggcatggga tggggtcgcg tcctatcagc ttgtaggcgg 180
ggtaatggcc cacctaggct tcgacgggta gccggcctga gagggcggac ggccacattg 240
ggactgagat acggcccaga ctcctacggg aggcagcagt ggggaatatt gcgcaatggg 300
ggaaaccctg acgcagcgac gccgcgtgcg ggatgaaggc cttcgggttg taaaccgctt 360
ttgattggga gcaagctttc gggtgagtgt acctttcgaa taagcgccgg ctaactacgt 420
gccagcagcc gcggtaatac gtagggcgca agcgttatcc ggaattattg ggcgtaaaga 480
gcttgtaggc ggttcgtcgc gtctggtgtg aaagcccatc gcttaacggt gggtttgcgc 540
cgggtacggg cgggctagag tgcagtaggg gagactggaa ttctcggtgt aacggtggaa 600
tgtgtagata tcgggaagaa caccaatggc gaaggcaggt ctctgggctg ttactgacgc 660
tgagaagcga aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa 720
cggtggacgc tggatgtggg gcccattcca cgggttctgt gtcggagcta acgcgttaag 780
cgtcccgcct ggggagtacg gccgcaaggc taaaactcaa agaaattgac gggggcccgc 840
acaagcggcg gagcatgcgg attaattcga tgcaacgcga agaaccttac ctgggcttga 900
catgtgcctg tcgactgcag agatgtggtt tcccttcggg gcaggttcac aggtggtgca 960
tggtcgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 1020
cgccctgtgt tgccagcggg ttatgccggg aactcacggg ggaccgccgg ggttaactcg 1080
gaggaaggtg gggatgacgt cagatcatca tgccccttac gtccagggct tcacgcatgc 1140
tacaatggcc ggtacaacgg gatgcgacat ggtgacatgg agcggatccc ttaaaaccgg 1200
tctcagttcg gatcgtagtc tgcaactcga ctacgtgaag gcggagtcgc tagtaatcgc 1260
gaatcagcaa cgtcgcggtg aatgcgttcc cgggccttgt acacaccgcc cgtca 1315
<210> 238
<211> 1445
<212> DNA
<213> Artificial Sequence
<220>
<223> Granulicatella_sp_M658_99_3
<220>
<221> misc_feature
<222> (73)..(73)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (180)..(180)
<223> n is a, c, g, or t
<400> 238
acgctggcgg cgtgcctaat acatgcaagt cgaacgcagt ttcattcacc gagtgcttgc 60
actcaccgaa tgnactgagt ggcgaacggg tgagtaacac gtgggtaacc tgcccatcag 120
tgggggataa cagtcggaaa cgactgctaa taccgcatga ttttcaacac cgcatggtgn 180
tgaaataaaa gacggctttg ctgtcgctga tggatggacc cgcggcgtat tagctagttg 240
gtgaggtaac ggctcaccaa ggcaatgata cgtagccggc ctgagagggt aatcggccac 300
attgggactg agacacggcc caaactccta cgggaggcag cagtagggaa tcttccgcaa 360
tggacgaaag tctgacggag caacgccgcg tgagtgaaga aggttttcgg atcgtaaaac 420
tctgttgtta gagaagaaca acctcttgag taactgtaag aggtctgacg gtatctaacc 480
agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 540
ccggatttat tgggcgtaaa gcgagtgcag gcggttcctt aagtctgatg tgaaagccca 600
cggcttaacc gtggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 660
aattccatgt gtagcggtgg aatgcgtaga tatatggagg aacaccagtg gcgaaggcga 720
ctctctggtc tgtaactgac gctgaggctc gaaagcgtgg gtagcaaaca ggattagata 780
ccctggtagt ccacgccgta aacgatgagt gctaggtgtt ggagggtttc cgcccttcag 840
tgccgcagtt aacgcattaa gcactccgcc tggggagtac ggccgcaagg ctgaaactca 900
aaggaattga cggggacccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 960
aagaacctta ccaagtcttg acatcctttg accactctag agatagagct ttcccttcgg 1020
ggacaaagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 1080
gtcccgcaac gagcgcaacc cttatcatta gttgccagca ttcagttggg cactctagtg 1140
atactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcagca tgccccttat 1200
gacttgggct acacacgtgc tacaatggat ggtacaacga gcagcaaacc cgcgagggca 1260
agcgaatctc ttaaagccat tctcagttcg gattgttctc tgcaactcga gaacatgaag 1320
ccggaatcgc tagtaatcgc ggatcagcac gccgcggtga atacgttccc gggtcttgta 1380
cacaccgccc gtcacaccac gagagtttgt aacacccaaa gtcggtgagg taacccttct 1440
gggag 1445
<210> 239
<211> 1453
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnobacterium_bovis
<400> 239
gtttgatcct ggctcaggat gaacgctggc ggcgtgctta acacatgcaa gtcgaacgaa 60
gcgcattgtt tgaattcttc ggaaggaaga taatgtgact gagtggcgga cgggtgagta 120
acgcgtgggt aacctgccat gtacaggggg acaacagttg gaaacggctg ctaataccgc 180
ataagcgcac gagattgcat gatctagtgt gaaaaactcc ggtggtatat gatggacccg 240
cgtctgatta gctagttggt aaggtaacgg cttaccaagg cgacgatcag tagccgacct 300
gagagggtga ccggccacat tgggactgag acacggccca gactcctacg ggaggcagca 360
gtggggaata ttgcacaatg ggcgaaagcc tgatgcagcg acgccgcgtg aacgaagaag 420
tatttcggta tgtaaagttc tatcagcagg gaagaagaaa tgacggtacc tgactaagaa 480
gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc gttatccgga 540
tttactgggt gtaaagggag cgcaggcggc ccggcaagtc tgatgtgaaa acccaaggct 600
caaccatggg attgcattgg aaactgtcga gctagagtat cggaggggta agtggaattc 660
ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa ggcggcttac 720
tggacgataa ctgacgctga ggctcgaaag cgtggggagc aaacaggatt agataccctg 780
gtagtccacg ccgtaaacga tgaatactag gtgtcgggtg ttattaacat tcggtgccgg 840
cgcaaacgca ataagtattc cacctgggga gtacgttcgc aagaatgaaa ctcaaaggaa 900
ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac 960
cttaccaagt cttgacatcc caatgacaat ctatgtaatg tagactctct tcggagcaat 1020
ggagacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aacccttgtc cttagtagcc agcagtaaga tgggcactct agggagactg 1140
ccagggataa cctggaggaa ggtggggatg acgtcaaatc atcatgcccc ttatgacttg 1200
ggctacacac gtgctacaat ggcgtaaaca aagtgaagcg agatggtgac attaagcgaa 1260
tcacaaaaat aacgtctcag ttcggactgt agtctgcaac tcgactacac gaagctggaa 1320
tcgctagtaa tcgcagatca gaatgctgcg gtgaatacgt tcccgggtct tgtacacacc 1380
gcccgtcaca ccatgggagt tggtaatgcc cgaagccggt gacctaaccg aaaggaagga 1440
gccgtcgaag gca 1453
<210> 240
<211> 1493
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnobacterium_bovis
<220>
<221> misc_feature
<222> (85)..(85)
<223> n is a, c, g, or t
<400> 240
gagtttgatc atggctcagg atgaacgctg gcggcgtgct taacacatgc aagtcgaacg 60
aagcacatta tttgaattct tcggnaggaa gataatgcga ctgagtggcg gacgggtgag 120
taacgcgtgg gtaacctgcc atgtacaggg ggacaacagt tggaaacggc tgctaatacc 180
gcataagcgc acgagattgc atgatctagt gtgaaaaact ccggtggtat atgatggacc 240
cgcgtctgat tagctagttg gtaaggtaac ggcttaccaa ggcgacgatc agtagccgac 300
ctgagagggt gaccggccac attgggactg agacacggcc cagactccta cgggaggcag 360
cagtggggaa tattgcacaa tgggcgaaag cctgatgcag cgacgccgcg tgaacgaaga 420
agtatttcgg tatgtaaagt tctatcagca gggaagaaaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgcaggcg gcccggcaag tctgatgtga aaacccaagg 600
ctcaaccatg ggattgcatt ggaaactgtc gagctagagt atcggagggg taagtggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacgat aactgacgct gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgaatact aggtgtcggg tgttatgaac attcggtgcc 840
ggcgcaaacg caataagtat tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttaccaa gtcttgacat cccaatgaca agctatgtaa tgtagcctct cttcggagca 1020
ttggagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaacccttg tccttagtag ccagcagtaa gatgggcact ctagggagac 1140
tgccagggat aacctggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgact 1200
tgggctacac acgtgctaca atggcgtaaa caaagtgaag cgagatggtg acattaagca 1260
aatcacaaaa ataacgtctc agttcggact gtagtctgca actcgactac acgaagctgg 1320
aatcgctagt aatcgcagat cagaatgctg cggtgaatac gttcccgggt cttgtacaca 1380
ccgcccgtca caccatggga gttggtaatg cccgaagccg gtgacctaac cgtaaggaag 1440
gagccgtcga aggcaggatc gataactggg gtgaagtcgt aacaaggtaa cca 1493
<210> 241
<211> 1519
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_1_1_57FAA
<400> 241
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc 60
gaagcacttt gcttagattc ttcggatgaa gaggattgtg actgagcggc ggacgggtga 120
gtaacgcgtg ggtaacctgc ctcatacagg gggataacag ttagaaatga ctgctaatac 180
cgcataagac cacagcaccg catggtgcgg gggtaaaaac tccggtggta tgagatggac 240
ccgcgtctga ttagctagtt ggtaaggtaa cggcttacca aggcgacgat cagtagccga 300
cctgagaggg tgaccggcca cattgggact gagacacggc ccaaactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcgacgccgc gtgagcgaag 420
aagtatttcg gtatgtaaag ctctatcagc agggaagaaa atgacggtac ctgactaaga 480
agcaccggct aaatacgtgc cagcagccgc ggtaatacgt atggtgcaag cgttatccgg 540
atttactggg tgtaaaggga gcgtagacgg atgggcaagt ctgatgtgaa aacccggggc 600
tcaaccccgg gactgcattg gaaactgttc atctagagtg ctggagaggt aagtggaatt 660
cctagtgtag cggtgaaatg cgtagatatt aggaggaaca ccagtggcga aggcggctta 720
ctggacagta actgacgttg aggctcgaaa gcgtggggag caaacaggat tagataccct 780
ggtagtccac gccgtaaacg atgactacta ggtgtcgggt ggcaaagcca ttcggtgccg 840
cagcaaacgc aataagtagt ccacctgggg agtacgttcg caagaatgaa actcaaagga 900
attgacgggg acccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa 960
ccttacctgc tcttgacatc ccgctgaccg gacggtaatg cgtccttccc ttcggggcag 1020
cggagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccctat ctttagtagc cagcggccag gccgggcact ctagagagac 1140
tgccggggat aacccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgagc 1200
agggctacac acgtgctaca atggcgtaaa caaagggaag cgagaccgcg aggtggagca 1260
aatcccaaaa ataacgtctc agttcggatt gtagtctgca actcgactac atgaagctgg 1320
aatcgctagt aatcgcgaat cagaatgtcg cggtgaatac gttcccgggt cttgtacaca 1380
ccgcccgtca caccatggga gtcagtaacg cccgaagtca gtgacccaac cgtaaggagg 1440
gagctgccga aggcgggacc gataactggg gtgaagtcgt aacaaggtag ccgtatcgga 1500
aggtgcggct ggatcacct 1519
<210> 242
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_1_4_56FAA
<400> 242
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcactt taccggattt cttcgggatg aaagttttgt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataaga ccacaggatt gcatgatccg gtggtaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attagctagt tggtaaggta acggcttacc aaggcgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgat 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gagaggcaag tctgatgtga aaacccgggg 600
ctcaaccccg ggactgcatt ggaaactgtt tttctagagt gtcggagagg taagtggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacgat gactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactgct aggtgtcggg aggcaaagcc tttcggtgcc 840
gcagcaaacg caataagcag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg cccttgacat ccggctgacc ggcgagtaat gtcgcctttc cttcgggaca 1020
gccgagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctta tctttagtag ccagcatttc ggatgggcac tctagagaga 1140
ctgccaggga taacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatggg 1200
cagggctaca cacgtgctac aatggcgtaa acaaagggag gcaagcctgc gagggtgagc 1260
aaatcccaaa aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agttggtaac gcccgaagtc agtgacccaa ccgtaaggag 1440
ggagctgccg aaggtgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 243
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_2_1_46FAA
<400> 243
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcgctt tcgattgaat cttcggagga aagaggaagt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg gctgctaata 180
ccgcataagc atacagcacc gcatggtgca gtgtgaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attaggtagt tggtggggta acggcctacc aagccgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgaaggaa 420
gaagtatttc ggtatgtaaa cttctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gaagtgcaag tctgaagtga aagcccgggg 600
ctcaaccccg tgactgcttt ggaaactgtg cttctagagt gtcggagagg taagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac atcagtggcg aaggcggctt 720
actggacgat aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg gtacaaagta cttcggtgcc 840
gcagccaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg gtcttgacat ctccctgact ggacagtaat gtgtcctttc tttcgggaca 1020
gggaagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tcttcagtag ccagcaagta aagttgggca ctctggagag 1140
actgccaggg ataacctgga ggaaggtggg gacgacgtca aatcatcatg ccccttatga 1200
ccagggctac acacgtgcta caatggcgta aacaaaggga agcaagcatg tgagtgtgag 1260
caaatctcaa aaataacgtc tcagttcgga ttgtagtctg caactcgact acatgaagct 1320
ggaatcgcta gtaatcgcga atcagaatgt cgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagttggtaa cgcccgaagt cagtgaccta accgaaagga 1440
aggagctgcc gaaggtggga ctgataactg gggtgaagtc gtaacaaggt agccgtatcg 1500
gaaggtgcgg ctggatcacc tcctttct 1528
<210> 244
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_2_1_58FAA
<400> 244
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgag 60
cgaagcacct tgacggattt cttcggattg aagccttggt gactgagcgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttggaaacg gctgctaata 180
ccgcataagc gcacagtacc gcatggtacg gtgtgaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attaggtagt tggtggggta acggcctacc aagccgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgat 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gcatggcaag ccagatgtga aagcccgggg 600
ctcaaccccg ggactgcatt tggaactgtc aggctagagt gtcggagagg aaagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
tctggacgat gactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgaatact aggtgtcggg tggcaaagcc attcggtgcc 840
gcagcaaacg caataagtat tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg gtcttgacat ccctctgacc gctctttaat cggagctttc cttcgggaca 1020
gaggagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tctttagtag ccagcatttt cggatgggca ctctagagag 1140
actgccaggg ataacctgga ggaaggtggg gatgacgtca aatcatcatg ccccttatga 1200
ccagggctac acacgtgcta caatggcgta aacaaaggga agcgagcccg cgagggggag 1260
caaatcccaa aaataacgtc tcagttcgga ttgtagtctg caactcgact acatgaagct 1320
ggaatcgcta gtaatcgcga atcagaatgt cgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagtcagtaa cgcccgaagt cagtgaccca accgcaagga 1440
gggagctgcc gaaggtggga ccgataactg gggtgaagtc gtaacaaggt agccgtatcg 1500
gaaggtgcgg ctggatcacc tcctttct 1528
<210> 245
<211> 1493
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_3_1_57FAA
<400> 245
acaagagagt ttgatcctgg ctcaggatga acgctggcgg cgtgcctaac acatgcaagt 60
cgaacgaagt taacgaggaa gttttcggat ggaatcggta taacttagtg gcggacgggt 120
gagtaacgcg tgggaaacct gccctgtacc gggggataac acttagaaat aggtgctaat 180
accgcataag cgcacggaac cgcatggttc gtgtgaaaaa ctccggtggt acaggatggt 240
cccgcgtctg attagccagt tggcagggta acggcctacc aaagcgacga tcagtagccg 300
gcctgagagg gtgaacggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagtgaa 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gcatggcaag ccagatgtga aaacccaggg 600
ctcaaccttg ggattgcatt tggaactgtc aggctggagt gcaggagagg taagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggactgt aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgcggtaaac gatgattgct aggtgtaggt gggtatggac ccatcggtgc 840
cgcagctaac gcaataagca atccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tcccaatgac gcacctgtaa agaggtgttc ccttcggggc 1020
attggagaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaaccctt attcttagta gccagcaggt aaagctgggc actctaagga 1140
gactgccggg gataacccgg aggaaggcgg ggatgacgtc aaatcatcat gccccttatg 1200
atttgggcta cacacgtgct acaatggcgt aaacaaaggg aagcgagaca gtgatgtgga 1260
gcaaatccca gaaataacgt ctcagttcgg attgtagtct gcaactcgac tacatgaagc 1320
tggaatcgct agtaatcgcg aatcagcatg tcgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagttggaa atgcccgaag tctgtgacct aaccgaaagg 1440
gaggagcagc cgaaggcagg tctgataact ggggtgaagt cgtaacaagg tag 1493
<210> 246
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_4_1_37FAA
<400> 246
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcactt gaatggaatt cttcggaagg aagctcaagt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataagc acacgtgatc gcatgatcga gtgtgaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attagctagt tggtggggta acggcccacc aaggcgacga tcagtagccg 300
gcctgagagg gtgaacggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgaaggat 420
gaagtatttc ggtatgtaaa cttctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gcagtgcaag tctgaagtga aagcccgggg 600
ctcaaccccg ggactgcttt ggaaactgtg cagctagagt gtcggagagg caagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
gctggacgat gactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg gagcaaagct cttcggtgcc 840
gcagccaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg ctcttgacat ccctctgacc ggcaagtaat gttgcctttc cttcgggaca 1020
gaggagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tcttcagtag ccagcggtaa ggccgggcac tctggagaga 1140
ctgccaggga taacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgag 1200
cagggctaca cacgtgctac aatggcgtaa acaaagggaa gcagagtcgt gaggccgagc 1260
aaatcccaaa aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacccaa ccgcaaggag 1440
ggagctgccg aaggtgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 247
<211> 1531
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_5_1_57FAA
<400> 247
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaacacat gcaagtcgaa 60
cgaagcgcct ggccccgact tcttcggaac gaggagcctt gcgactgagt ggcggacggg 120
tgagtaacgc gtgggcaacc tgccttgcac tgggggataa cagccagaaa tggctgctaa 180
taccgcataa gaccgaagcg ccgcatggcg cggcggccaa agccccggcg gtgcaagatg 240
ggcccgcgtc tgattaggta gttggcgggg taacggccca ccaagccgac gatcagtagc 300
cgacctgaga gggtgaccgg ccacattggg actgagacac ggcccagact cctacgggag 360
gcagcagtgg ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgaagg 420
atgaagtatt tcggtatgta aacttctatc agcagggaag aagatgacgg tacctgacta 480
agaagccccg gctaactacg tgccagcagc cgcggtaata cgtagggggc aagcgttatc 540
cggatttact gggtgtaaag ggagcgtaga cggcgatgca agccagatgt gaaagcccgg 600
ggctcaaccc cgggactgca tttggaactg cgtggctgga gtgtcggaga ggcaggcgga 660
attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaaggcggc 720
ctgctggacg atgactgacg ttgaggctcg aaagcgtggg gagcaaacag gattagatac 780
cctggtagtc cacgccgtaa acgatgacta ctaggtgtcg ggtggcaagg ccattcggtg 840
ccgcagcaaa cgcaataagt agtccacctg gggagtacgt tcgcaagaat gaaactcaaa 900
ggaattgacg gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc tgatcttgac atcccgatgc caaagcgcgt aacgcgctct ttcttcggaa 1020
catcggtgac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaacccc tatcttcagt agccagcatt atggatgggc actctggaga 1140
gactgccagg gagaacctgg aggaaggtgg ggatgacgtc aaatcatcat gccccttatg 1200
accagggcta cacacgtgct acaatggcgt aaacaaaggg aggcgaaccc gcgagggtgg 1260
gcaaatccca aaaataacgt ctcagttcgg attgtagtct gcaactcgac tacatgaagc 1320
tggaatcgct agtaatcgcg aatcagaatg tcgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagtcagta acgcccgaag ccggtgaccc aacccgtaag 1440
ggagggagcc gtcgaaggtg ggaccgataa ctggggtgaa gtcgtaacaa ggtagccgta 1500
tcggaaggtg cggctggatc acctcctttc t 1531
<210> 248
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_6_1_63FAA
<400> 248
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgag 60
cgaagcactt atcattgact cttcggaaga tttgatattt gactgagcgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag gggaataaca gttagaaatg gctgctaatg 180
ccgcataagc gcacaggacc gcatggtctg gtgtgaaaaa ctgaggtggt atgagatgga 240
cccgcgtctg attaggtagt tggtggggta acggcctacc aagccgacga tcagtagccg 300
gcctgagagg gtgaacggcc acattgggac tgagacacgg cccagactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgaaggaa 420
gaagtatctc ggtatgtaaa cttctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gaagagcaag tctgatgtga aaggctgggg 600
cttaacccca ggactgcatt ggaaactgtt tttctagagt gccggagagg taagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacggt aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgaatact aggtgtcggg gtgcaaagca gttcggtgcc 840
gcagcaaacg caataagtat tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttaccaa gtcttgacat ctgcctgacc gttccttaac cggagctttc cttcgggaca 1020
ggcaagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tccttagtag ccagcagtcc ggctgggcac tctagggaga 1140
ctgccgggga taacccggag gaaggcgggg acgacgtcaa atcatcatgc cccttatgat 1200
ttgggctaca cacgtgctac aatggcgtaa acaaagggaa gcgaagcggt gacgcttagc 1260
aaatctcaaa aataacgtcc cagttcggac tgcagtctgc aactcgactg cacgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacccaa ccttatggag 1440
ggagctgccg aaggcgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 249
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_8_1_57FAA
<400> 249
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaacacat gcaagtcgag 60
cgaagcactt tgcttagatt cttcggatga agaggattgt gactgagcgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataaga ccacagcacc gcatggtgcg ggggtaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attagctagt tggtaaggta acggcttacc aaggcgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgaa 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gatgggcaag tctgatgtga aaacccgggg 600
ctcaaccccg ggactgcatt ggaaactgtt catctagagt gctggagagg taagtggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacagt aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg tggcaaagcc attcggtgcc 840
gcagcaaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg ctcttgacat cccgctgacc ggacggtaat gcgtccttcc cttcggggca 1020
gcggagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tctttagtag ccagcggcca ggccgggcac tctagagaga 1140
ctgccgggga taacccggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgag 1200
cagggctaca cacgtgctac aatggcgtaa acaaagggaa gcgagaccgc gaggtggagc 1260
aaatcccaaa aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacccaa ccgtaaggag 1440
ggagctgccg aaggcgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 250
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_9_1_43BFAA
<400> 250
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcactt gaatggaatt cttcggaagg aagctcaagt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataagc acacgtgatc gcatgatcga gtgtgaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attagctagt tggtggggta atggcccacc aaggcgacga tcagtagccg 300
gcctgagagg gtgaacggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgaaggat 420
gaagtatttc ggtatgtaaa cttctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccg cggtaatacg tagggggcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gcagtgcaag tctgaagtga aagcccgggg 600
ctcaaccccg ggactgcttt ggaaactgtg cagctagagt gtcggagagg caagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
gctggacgat gactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg gagcaaagct cttcggtgcc 840
gcagccaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg ctcttgacat ccctctgacc gctctttaat cggagctttc cttcgggaca 1020
gaggagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tcttcagtag ccagcggtaa ggccgggcac tctggagaga 1140
ctgccaggga taacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgag 1200
cagggctaca cacgtgctac aatggcgtaa acaaagggaa gcagagtcgt gaggccgagc 1260
aaatcccaaa aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacccaa ccgcaaggag 1440
ggagctgccg aaggtgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 251
<211> 1487
<212> DNA
<213> Artificial Sequence
<220>
<223> Lachnospiraceae_bacterium_oral_taxon_F15
<400> 251
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gaagcattta gaagttttcg gacggaagaa tgacttagtg gcggacgggt gagtaacgcg 120
tgggtaacct gccttataca gggggataac agttggaaac gactgctaat accgcataac 180
ccgatagagt cgcatgactt agtcggaaaa gatttatcgg tataagatgg acccgcgtct 240
gattagctag ttggtgaggt aatggcccac caaggcgacg atcagtagcc ggcttgagag 300
agtgaacggc cacattggga ctgagacacg gcccaaactc ctacgggagg cagcagtggg 360
gaatattgca caatggggga aaccctgatg cagcaacgcc gcgtgaagga tgaagtattt 420
cggtatgtaa acttctatca gcagggaaga aattgacggt acctgactaa gaagccccgg 480
ctaactacgt gccagcagcc gcggtaatac gtagggggca agcgttatcc ggatttactg 540
ggtgtaaagg gagcgtaggc ggcaatgcaa gtccgatgtg aaagcccggg gctcaacccc 600
gggactgcat tagaaactgt gttgctagag tgcaggagag gtaagtggaa ttcctagtgt 660
agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcgact tactggactg 720
aaactgacgc tgaggctcga aagcgtgggg agcaaacagg attagatacc ctggtagtcc 780
acgccgtaaa cgatgaatac taggtgtcgg ggcccatccg ggcttcggtg ccgcggctaa 840
cgcaataagt attccacctg gggagtacgt tcgcaagaat gaaactcaaa ggaattgacg 900
gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc 960
aagtcttgac atcccattga ccgtcccgta acggggactt ctcttcggag caatggagac 1020
aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga 1080
gcgcagccct tatctttagt agccagcatt taaggtgggc actctagaga gactgccggg 1140
gataacccgg aggaaggcgg ggatgacgtc aaatcatcat gccccttatg atttgggcta 1200
cacacgtgct acaatggcgt aaacaaaggg aagcaacagg gtgacctcaa gcaaatccca 1260
aaaataacgt cccagttcgg attgtagtct gcaactcgac tacatgaagc tggaatcgct 1320
agtaatcgcg gatcagaatg ccgcggtgaa tacgttcccg ggtcttgtac acaccgcccg 1380
tcacaccatg ggagtcggaa atgcccgaag tcagtgaccc aaccgcaagg agggagctgc 1440
cgaaggtgga gccgataact ggggtgaagt cgtaacaagg tagccgt 1487
<210> 252
<211> 1561
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_acidophilus
<400> 252
gagagtttga tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag 60
cgagctgaac caacagattc acttcggtga tgacgttggg aacgcgagcg gcggatgggt 120
gagtaacacg tggggaacct gccccatagt ctgggatacc acttggaaac aggtgctaat 180
accggataag aaagcagatc gcatgatcag cttataaaag gcggcgtaag ctgtcgctat 240
gggatggccc cgcggtgcat tagctagttg gtagggtaac ggcctaccaa ggcaatgatg 300
catagccgag ttgagagact gatcggccac attgggactg agacacggcc caaactccta 360
cgggaggcag cagtagggaa tcttccacaa tggacgaaag tctgatggag caacgccgcg 420
tgagtgaaga aggttttcgg atcgtaaagc tctgttgttg gtgaagaagg atagaggtag 480
taactggcct ttatttgacg gtaatcaacc agaaagtcac ggctaactac gtgccagcag 540
ccgcggtaat acgtaggtgg caagcgttgt ccggatttat tgggcgtaaa gcgagcgcag 600
gcggaagaat aagtctgatg tgaaagccct cggcttaacc gaggaactgc atcggaaact 660
gtttttcttg agtgcagaag aggagagtgg aactccatgt gtagcggtgg aatgcgtaga 720
tatatggaag aacaccagtg gcgaaggcgg ctctctggtc tgcaactgac gctgaggctc 780
gaaagcatgg gtagcgaaca ggattagata ccctggtagt ccatgccgta aacgatgagt 840
gctaagtgtt gggaggtttc cgcctctcag tgctgcagct aacgcattaa gcactccgcc 900
tggggagtac gaccgcaagg ttgaaactca aaggaattga cgggggcccg cacaagcggt 960
ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccaggtcttg acatctagtg 1020
caatccgtag agatacggag ttcccttcgg ggacactaag acaggtggtg catggctgtc 1080
gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac gagcgcaacc cttgtcatta 1140
gttgccagca ttaagttggg cactctaatg agactgccgg tgacaaaccg gaggaaggtg 1200
gggatgacgt caagtcatca tgccccttat gacctgggct acacacgtgc tacaatggac 1260
agtacaacga ggagcaagcc tgcgaaggca agcgaatctc ttaaagctgt tctcagttcg 1320
gactgcagtc tgcaactcga ctgcacgaag ctggaatcgc tagtaatcgc ggatcagcac 1380
gccgcggtga atacgttccc gggccttgta cacaccgccc gtcacaccat gggagtctgc 1440
aatgcccaaa gccggtggcc taaccttcgg gaaggagccg tctaaggcag ggcagatgac 1500
tggggtgaag tcgtaacaag gtagccgtag gagaacctgc ggctggatca cctcctttct 1560
a 1561
<210> 253
<211> 1572
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_acidophilus
<400> 253
aaaacgagag tttgatcctg gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag 60
tcgagcgagc tgaaccaaca gattcacttc ggtgatgacg ttgggaacgc gagcggcgga 120
tgggtgagta acacgtgggg aacctgcccc atagtctggg ataccacttg gaaacaggtg 180
ctaataccgg ataagaaagc agatcgcatg atcagcttat aaaaggcggc gtaagctgtc 240
gctatgggat ggccccgcgg tgcattagct agttggtagg gtaacggcct accaaggcaa 300
tgatgcatag ccgagttgag agactgatcg gccacattgg gactgagaca cggcccaaac 360
tcctacggga ggcagcagta gggaatcttc cacaatggac gaaagtctga tggagcaacg 420
ccgcgtgagt gaagaaggtt ttcggatcgt aaagctctgt tgttggtgaa gaaggataga 480
ggtagtaact ggcctttatt tgacggtaat caaccagaaa gtcacggcta actacgtgcc 540
agcagccgcg gtaatacgta ggtggcaagc gttgtccgga tttattgggc gtaaagcgag 600
cgcaggcgga agaataagtc tgatgtgaaa gccctcggct taaccgagga actgcatcgg 660
aaactgtttt tcttgagtgc agaagaggag agtggaactc catgtgtagc ggtggaatgc 720
gtagatatat ggaagaacac cagtggcgaa ggcggctctc tggactgcaa ctgacgctga 780
ggctagaaag catgggtagc gaacaggatt agataccttg gtagtccatg ccgaaaacga 840
tgagtgctaa gtgttgggag gtttccgcct ttcagagctg cagctaacgc attaagcact 900
ccgcctgggg agtacgaccg catggttgat actcaaagga attgacgggg gcccgcacaa 960
gcgggggagc atgtggttta attcgaagca acgcgaagaa ccttaccagg tcttgacatc 1020
tagtgcaatc cgtagagata cggagttccc ttcggggaca ctaagacagg tggtgcatgg 1080
ctgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg caacctttgt 1140
cattagttgc cagcattaag ttgggcactc taatgagact gccggtgaca aaccggagga 1200
aggtggggat gacgtcaagt catcatgccc cttatgacct gggctacaca cgtgctacat 1260
tggacagtac aacgaggagc aagcctgcga aggcaagcga atctcttaaa gctgatctca 1320
gttcggactg cagtctgcaa ctcgactgca cgaagctgga atcgctagta atcgcggatc 1380
agcacgccgc ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac accatgggag 1440
tctgcaatgc ccaaagccgg tggcctaacc ttcgggatgg agccgtctaa ggcagggcag 1500
atgactgggg tgaagtcgta acaaggtagc cgtaggagaa cctgcggctg gatcacctcc 1560
tttctaagga ag 1572
<210> 254
<211> 1276
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_fermentum
<400> 254
aacgagtggc ggacgggtga gtaacacgta ggtaacctgc ccagaagcgg gggacaacat 60
ttggaaacag atgctaatac cgcataacaa cgttgttcgc atgaacaacg cttaaaagat 120
ggcttctcgc tatcacttct ggatggacct gcggtgcatt agcttgttgg tggggtaacg 180
gcctaccaag gcgatgatgc atagccgagt tgagagactg atcggccaca atgggactga 240
gacacggccc atactcctac gggaggcagc agtagggaat cttccacaat gggcgcaagc 300
ctgatggagc aacaccgcgt gagtgaagaa gggtttcggc tcgtaaagct ctgttgttaa 360
agaagaacac gtatgagagt aactgttcat acgttgacgg tatttaacca gaaagtcacg 420
gctaactacg tgccagcagc cgcggtaata cgtaggtggc aagcgttatc cggatttatt 480
gggcgtaaag agagtgcagg cggttttcta agtctgatgt gaaagccttc ggcttaaccg 540
gagaagtgca tcggaaactg gataacttga gtgcagaaga gggtagtgga actccatgtg 600
tagcggtgga atgcgtagat atatggaaga acaccagtgg cgaaggcggc tacctggtct 660
gcaactgacg ctgagactcg aaagcatggg tagcgaacag gattagatac cctggtagtc 720
catgccgtaa acgatgagtg ctaggtgttg gagggtttcc gcccttcagt gccggagcta 780
acgcattaag cactccgcct ggggagtacg accgcaaggt tgaaactcaa aggaattgac 840
gggggcccgc acaagcggtg gagcatgtgg tttaattcga agctacgcga agaaccttac 900
caggtcttga catcttgcgc caaccctaga gatagggcgt ttccttcggg aacgcaatga 960
caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1020
agcgcaaccc ttgttactag ttgccagcat taagttgggc actctagtga gactgccggt 1080
gacaaaccgg aggaaggtgg ggacgacgtc agatcatcat gccccttatg acctgggcta 1140
cacacgtgct acaatggacg gtacaacgag tcgcgaactc gcgagggcaa gcaaatctct 1200
taaaaccgtt ctcagttcgg actgcaggct gcaactcgcc tgcacgaagt cggaatcgct 1260
agtaatcgcg gatcag 1276
<210> 255
<211> 1373
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_fermentum
<400> 255
ttttatatga gagtttgatc ctggctcagg atgaacgccg gcggtgtgcc taatacatgc 60
aagtcgaacg cgttggccca attgattgat ggtgcttgca cctgattgat tttggtcgcc 120
aacgagtggc ggacgggtga gtaacacgta ggtaacctgc ccagaagcgg gggacaacat 180
ttggaaacag atgctaatac cgcataacaa cgttgttcgc atgaacaacg cttaaaagat 240
ggcttctcgc tatcacttct ggatggacct gcggtgcatt agcttgttgg tggggtaacg 300
gcctaccaag gcgatgatgc atagccgagt tgagagactg atcggccaca atgggactga 360
gacacggccc atactcctac gggaggcagc agtagggaat cttccacaat gggcgcaagc 420
ctgatggagc aacaccgcgt gagtgaagaa gggtttcggc tcgtaaagct ctgttgttaa 480
agaagaacac gtatgagagt aactgttcat acgttgacgg tatttaacca gaaagtcacg 540
gctaactacg tgccagcagc cgcggtaata cgtaggtggc aagcgttatc cggatttatt 600
gggcgtaaag agagtgcagg cggttttcta agtctgatgt gaaagccttc ggcttaaccg 660
gagaagtgca tcggaaactg gataacttga gtgcagaaga gggtagtgga actccatgtg 720
tagcggtgga atgcgtagat atatggaaga acaccagtgg cgaaggcggc tacctggtct 780
gcaactgacg ctgagactcg aaagcatggg tagcgaacag gattagatac cctggtagtc 840
catgccgtaa acgatgagtg ctaggtgttg gagggtttcc gcccttcagt gccggagcta 900
acgcattaag cactccgcct ggggagtacg accgcaaggt tgaaactcaa aggaattgac 960
gggggcccgc acaagcggtg gagcatgtgg tttaattcga agctacgcga agaaccttac 1020
caggtcttga catcttgcgc caaccctaga gatagggcgt ttccttcggg aacgcaatga 1080
caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1140
agcgcaaccc ttgttactag ttgccagcat taagttgggc actctagtga gactgccggt 1200
gacaaaccgg aggaaggtgg ggacgacgtc agatcatcat gccccttatg acctgggcta 1260
cacacgtgct acaatggacg gtacaacgag tcgcgaactc gcgagggcaa gcaaatctct 1320
taaaaccgtt ctcagttcgg actgcaggct gcaactcgcc tgcacgaagt cgg 1373
<210> 256
<211> 1580
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_fermentum
<400> 256
ttttatatga gagtttgatc ctggctcagg atgaacgccg gcggtgtgcc taatacatgc 60
aagtcgaacg cgttggccca attgattgat ggtgcttgca cctgattgat tttggtcgcc 120
aacgagtggc ggacgggtga gtaacacgta ggtaacctgc ccagaagcgg gggacaacat 180
ttggaaacag atgctaatac cgcataacag cgttgttcgc atgaacaacg cttaaaagat 240
ggcttctcgc tatcacttct ggatggacct gcggtgcatt agcttgttgg tggggtaacg 300
gcctaccaag gcgatgatgc atagccgagt tgagagactg atcggccaca atgggactga 360
gacacggccc atactcctac gggaggcagc agtagggaat cttccacaat gggcgcaagc 420
ctgatggagc aacaccgcgt gagtgaagaa gggtttcggc tcgtaaagct ctgttgttaa 480
agaagaacac gtatgagagt aactgttcat acgttgacgg tatttaacca gaaagtcacg 540
gctaactacg tgccagcagc cgcggtaata cgtaggtggc aagcgttatc cggatttatt 600
gggcgtaaag agagtgcagg cggttttcta agtctgatgt gaaagccttc ggcttaaccg 660
gagaagtgca tcggaaactg gataacttga gtgcagaaga gggtagtgga actccatgtg 720
tagcggtgga atgcgtagat atatggaaga acaccagtgg cgaaggcggc tacctggtct 780
gcaactgacg ctgagactcg aaagcatggg tagcgaacag gattagatac cctggtagtc 840
catgccgtaa acgatgagtg ctaggtgttg gagggtttcc gcccttcagt gccggagcta 900
acgcattaag cactccgcct ggggagtacg accgcaaggt tgaaactcaa aggaattgac 960
gggggcccgc acaagcggtg gagcatgtgg tttaattcga agctacgcga agaaccttac 1020
caggtcttga catcttgcgc caaccctaga gatagggcgt ttccttcggg aacgcaatga 1080
caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1140
agcgcaaccc ttgttactag ttgccagcat taagttgggc actctagtga gactgccggt 1200
gacaaaccgg aggaaggtgg ggacgacgtc agatcatcat gccccttatg acctgggcta 1260
cacacgtgct acaatggacg gtacaacgag tcgcgaactc gcgagggcaa gcaaatctct 1320
taaaaccgtt ctcagttcgg actgcaggct gcaactcgcc tgcacgaagt cggaatcgct 1380
agtaatcgcg gatcagcatg ccgcggtgaa tacgttcccg ggccttgtac acaccgcccg 1440
tcacaccatg agagtttgta acacccaaag tcggtggggt aaccttttag gagccagccg 1500
cctaaggtgg gacagatgat tagggtgaag tcgtaacaag gtagccgtag gagaacctgc 1560
ggctggatca cctcctttct 1580
<210> 257
<211> 1580
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_fermentum
<400> 257
ttttatatga gagtttgatc ctggctcagg atgaacgccg gcggtgtgcc taatacatgc 60
aagtcgaacg cgttggccca attgattgat ggtgcttgca cctgattgat tttggtcgcc 120
aacgagtggc ggacgggtga gtaacacgta ggtaacctgc ccagaagcgg gggacaacat 180
ttggaaacag atgctaatac cgcataacaa cgttgttcgc atgagcaacg cttaaaagat 240
ggcttctcgc tatcacttct ggatggacct gcggtgcatt agcttgttgg tggggtaacg 300
gcctaccaag gcgatgatgc atagccgagt tgagagactg atcggccaca atgggactga 360
gacacggccc atactcctac gggaggcagc agtagggaat cttccacaat gggcgcaagc 420
ctgatggagc aacaccgcgt gagtgaagaa gggtttcggc tcgtaaagct ctgttgttaa 480
agaagaacac gtatgagagt aactgttcat acgttgacgg tatttaacca gaaagtcacg 540
gctaactacg tgccagcagc cgcggtaata cgtaggtggc aagcgttatc cggatttatt 600
gggcgtaaag agagtgcagg cggttttcta agtctgatgt gaaagccttc ggcttaaccg 660
gagaagtgca tcggaaactg gataacttga gtgcagaaga gggtagtgga actccatgtg 720
tagcggtgga atgcgtagat atatggaaga acaccagtgg cgaaggcggc tacctggtct 780
gcaactgacg ctgagactcg aaagcatggg tagcgaacag gattagatac cctggtagtc 840
catgccgtaa acgatgagtg ctaggtgttg gagggtttcc gcccttcagt gccggagcta 900
acgcattaag cactccgcct ggggagtacg accgcaaggt tgaaactcaa aggaattgac 960
gggggcccgc acaagcggtg gagcatgtgg tttaattcga agctacgcga agaaccttac 1020
caggtcttga catcttgcgc caaccctaga gatagggcgt ttccttcggg aacgcaatga 1080
caggtggtgc atggtcgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg 1140
agcgcaaccc ttgttactag ttgccagcat taagttgggc actctagtga gactgccggt 1200
gacaaaccgg aggaaggtgg ggacgacgtc agatcatcat gccccttatg acctgggcta 1260
cacacgtgct acaatggacg gtacaacgag tcgcaaactc gcgagggcaa gcaaatctct 1320
taaaaccgtt ctcagttcgg actgcaggct gcaactcgcc tgcacgaagt cggaatcgct 1380
agtaatcgcg gatcagcatg ccgcggtgaa tacgttcccg ggccttgtac acaccgcccg 1440
tcacaccatg agagtttgta acacccaaag tcggtggggt aaccttttag gagccagccg 1500
cctaaggtgg gacagatgat tagggtgaag tcgtaacaag gtagccgtag gagaacctgc 1560
ggctggatca cctcctttct 1580
<210> 258
<211> 1201
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_fermentum
<220>
<221> misc_feature
<222> (12)..(12)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (197)..(197)
<223> n is a, c, g, or t
<400> 258
tgagtttgat cntggctcag gatgaacgcc ggcggtgtgc ctaatacatg caagtcgaac 60
gagtggcgga cgggtgagta acacgtaggt aacctgccca gaagcggggg acaacatttg 120
gaaacagatg ctaataccgc ataacaaaag tcacttctgg atggacctgc ggtgcattag 180
cttgttggtg gggtaanggc ctaccaaggc gatgatgcat agccgagttg agagactgat 240
cggccacaat gggactgaga cacggcccat actcctacgg gaggcagcag tagggaatct 300
tccacaatgg gcgcaagcct gatggagcaa caccgcgtga gtgaagaagg gtttcggctc 360
gtaaagctct gttgttaaag aagatgacgg tatttaacca gaaagtcacg gctaactacg 420
tgccagcagc cgcggtaata cgtaggtggc aagcgttatc cggatttatt gggcgtaaag 480
agagtgcagg cggttttcta agtctgatgt gaaagccttc ggcttaaccg gagaagtgca 540
tcggaaactg gataacttga gtgcagaaga gggtagtgga actccatgtg tagcggtgga 600
atgcgtagat atatggaaga acaccagtgg cgaaggcggc tacctggtct gactgacgct 660
gagactcgaa agcatgggta gcgaacagga ttagataccc tggtagtcca tgccgtaaac 720
gatgagtgct aggtgttgga gcttcagtgc cggagctaac gcattaagca ctccgcctgg 780
ggagtacgac cgcaaggttg aaactcaaag gaattgacgg gggcccgcac aagcggtgga 840
gcatgtggtt taattcgaag ctacgcgaag aaccttacca ggtcttgaca tcgacaggtg 900
gtgcatggtc gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 960
acccttgtta ctagttgcca gcatgggcac tctagtgaga ctgccggtga caaaccggag 1020
gaaggtgggg acgacgtcag atcatcatgc cccttatgac ctgggctaca cacgtgctac 1080
aatggacggc aacgagtcgc gaactcgcga gggcaagcaa atctcttccg ttctcagttc 1140
ggatgcaggc tgcaactcgc ctgcagaagt cggaatcgct agtaatcgcg gatcagcatg 1200
c 1201
<210> 259
<211> 1225
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_fermentum
<400> 259
agtggcggac gggtgagtaa cacgtaggta acctgcccag aagcggggga caacatttgg 60
aaacagatgc taataccgca taacaaaagt cacttctgga tggacctgcg gtgcattagc 120
ttgttggtgg ggtaacggcc taccaaggcg atgatgcata gccgagttga gagactgatc 180
ggccacaatg ggactgagac acggcccata ctcctacggg aggcagcagt agggaatctt 240
ccacaatggg cgcaagcctg atggagcaac accgcgtgag tgaagaaggg tttcggctcg 300
taaagctctg ttgttaaaga agatgacggt atttaaccag aaagtcacgg ctaactacgt 360
gccagcagcc gcggtaatac gtaggtggca agcgttatcc ggatttattg ggcgtaaaga 420
gagtgcaggc ggttttctaa gtctgatgtg aaagccttcg gcttaaccgg agaagtgcat 480
cggaaactgg ataacttgag tgcagaagag ggtagtggaa ctccatgtgt agcggtggaa 540
tgcgtagata tatggaagaa caccagtggc gaaggcggct acctggtctg actgacgctg 600
agactcgaaa gcatgggtag cgaacaggat tagataccct ggtagtccat gccgtaaacg 660
atgagtgcta ggtgttggag cttcagtgcc ggagctaacg cattaagcac tccgcctggg 720
gagtacgacc gcaaggttga aactcaaagg atttgacggg ggcccgcaca agcggtggag 780
catgtggttt aattcgaagc tacgcgaaga accttaccag gtcttgacat cgacaggtgg 840
tgcatggtcg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 900
cccttgttac tagttgccag catgggcact ctagtgagac tgccggtgac aaaccggagg 960
aaggtgggga cgacgtcaga tcatcatgcc ccttatgacc tgggctacac acgtgctaca 1020
atggacggca acgagtcgcg aactcgcgag ggcaagcaaa tctcttccgt tctcagttcg 1080
gatgcaggct gcaactcgcc tgcagaagtc ggaatcgcta gtaatcgcgg atcagcatgc 1140
cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga gagtttgtaa 1200
cacccaaagt cggtgggtag ccagc 1225
<210> 260
<211> 1571
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 260
tgagagtttg atcctggctc aggacgaacg ctggcggcgt gcctaataca tgcaagtcga 60
gcgagcttgc ctagatgaat ttggtgcttg caccagatga aactagatac aagcgagcgg 120
cggacgggtg agtaacacgt gggtaacctg cccaagagac tgggataaca cctggaaaca 180
gatgctaata ccggataaca acactagacg catgtctaga gtttaaaaga tggttctgct 240
atcactcttg gatggacctg cggtgcatta gctagttggt aaggcaacgg cttaccaagg 300
caatgatgca tagccgagtt gagagactga tcggccacat tgggactgag acacggccca 360
aactcctacg ggaggcagca gtagggaatc ttccacaatg gacgcaagtc tgatggagca 420
acgccgcgtg agtgaagaag ggtttcggct cgtaaagctc tgttggtagt gaagaaagat 480
agaggtagta actggccttt atttgacggt aattacttag aaagtcacgg ctaactacgt 540
gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttattg ggcgtaaagc 600
gagtgcaggc ggttcaataa gtctgatgtg aaagccttcg gctcaaccgg agaattgcat 660
cagaaactgt tgaacttgag tgcagaagag gagagtggaa ctccatgtgt agcggtggaa 720
tgcgtagata tatggaagaa caccagtggc gaaggcggct ctctggtctg caactgacgc 780
tgaggctcga aagcatgggt agcgaacagg attagatacc ctggtagtcc atgccgtaaa 840
cgatgagtgc taagtgttgg gaggtttccg cctctcagtg ctgcagctaa cgcattaagc 900
actccgcctg gggagtacga ccgcaaggtt gaaactcaaa ggaattgacg ggggcccgca 960
caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 1020
atccagtgca aacctaagag attaggagtt cccttcgggg acgctgagac aggtggtgca 1080
tggctgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 1140
tgtcattagt tgccatcatt aagttgggca ctctaatgag actgccggtg acaaaccgga 1200
ggaaggtggg gatgacgtca agtcatcatg ccccttatga cctgggctac acacgtgcta 1260
caatggacgg tacaacgaga agcgaacctg cgaaggcaag cggatctctg aaagccgttc 1320
tcagttcgga ctgtaggctg caactcgcct acacgaagct ggaatcgcta gtaatcgcgg 1380
atcagcacgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1440
gagtctgtaa cacccaaagc cggtgggata acctttatag gagtcagccg tctaaggtag 1500
gacagatgat tagggtgaag tcgtaacaag gtagccgtag gagaacctgc ggctggatca 1560
cctcctttct a 1571
<210> 261
<211> 1533
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 261
gagtttgatc ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg 60
agcttgccta gatgaatttg gtgcttgcac caaatgaaac tagatacaag cgagcggcgg 120
acgggtgagt aacacgtggg taacctgccc aagagactgg gataacacct ggaaacagat 180
gctaataccg gataacaaca ctagacgcat gtctagagtt taaaagatgg ttctgctatc 240
actcttggat ggacctgcgg tgcattagct agttggtaag gtaacggctt accaaggcaa 300
tgatgcatag ccgagttgag agactgatcg gccacattgg gactgagaca cggcccaaac 360
tcctacggga ggcagcagta gggaatcttc cacaatggac gcaagtctga tggagcaacg 420
ccgcgtgagt gaagaagggt ttcggctcgt aaagctctgt tggtagtgaa gaaagataga 480
ggtagtaact ggcctttatt tgacggtaat tacttagaaa gtcacggcta actacgtgcc 540
agcagccgcg gtaatacgta ggtggcaagc gttgtccgga tttattgggc gtaaagcgag 600
tgcaggcggt tcaataagtc tgatgtgaaa gccttcggct caaccggaga attgcatcag 660
aaactgttga acttgagtgc agaagaggag agtggaactc catgtgtagc ggtggaatgc 720
gtagatatat ggaagaacac cagtggcgaa ggcggctctc tggtctgcaa ctgacgctga 780
ggctcgaaag catgggtagc gaacaggatt agataccctg gtagtccatg ccgtaaacga 840
tgagtgctaa gtgttgggag gtttccgcct ctcagtgctg cagctaacgc attaagcact 900
ccgcctgggg agtacgaccg caaggttgaa actcaaagga attgacgggg gcccgcacaa 960
gcggtggagc atgtggttta attcgaagca acgcgaagaa ccttaccagg tcttgacatc 1020
cagtgcaaac ctaagagatt aggagttccc ttcggggacg ctgagacagg tggtgcatgg 1080
ctgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg caacccttgt 1140
cattagttgc catcattaag ttgggcactc taatgagact gccggtgaca aaccggagga 1200
aggtggggat gacgtcaagt catcatgccc cttatgacct gggctacaca cgtgctacaa 1260
tggacggtac aacgagaagc gaacctgcga aggcaagcgg atctctgaaa gccgttctca 1320
gttcggactg taggctgcaa ctcgcctaca cgaagctgga atcgctagta atcgcggatc 1380
agcacgccgc ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac accatgagag 1440
tctgtaacac ccaaagccgg tgggataacc tttataggag tcagccgtct aaggtaggac 1500
agatgattag ggtgaagtcg taacaaggta gcc 1533
<210> 262
<211> 1570
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 262
tgagagtttg atcctggctc aggacgaacg ctggcggcgt gcctaataca tgcaagtcga 60
gcgagcttgc ctagatgaat ttggtgcttg caccaaatga aactagatac aagcgagcgg 120
cggacgggtg agtaacacgt gggtaacctg cccaagagac tgggataaca cctggaaaca 180
gatgctaata ccggataaca acactagacg catgtctaga gtttaaaaga tggttctgct 240
atcactcttg gatggacctg cggtgcatta gctagttggt aaggtaacgg cttaccaagg 300
caatgatgca tagccgagtt gagagactga tcggccacat tgggactgag acacggccca 360
aactcctacg ggaggcagca gtagggaatc ttccacaatg gacgcaagtc tgatggagca 420
acgccgcgtg agtgaagaag ggtttcggct cgtaaagctc tgttggtagt gaagaaagat 480
agaggtagta actggccttt atttgacggt aattacttag aaagtcacgg ctaactacgt 540
gccagcagcc gcggtaatac gtaggtggca agcgctgtcc ggatttattg ggcgtaaagc 600
gagtgcaggc ggttcaataa gtctgatgtg aaagcctttg gctcaaccgg agaattgcat 660
cagaaactgt tgaacttgag tgcagaagag gagagtggaa ctccatgtgt agcggtggaa 720
tgcgtagata tatggaagaa caccagtggc gaaggcggct ctctggtctg caactgacgc 780
tgaggctcga aagcatgggt agcgaacagg attagatacc ctggtagtcc atgccgtaaa 840
cgatgagtgc taagtgttgg gaggtttccg cctctcagtg ctgcagctaa cgcattaagc 900
actccgcctg gggagtacga ccgcaaggtt gaaactcaaa ggaattgacg ggggcccgca 960
caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 1020
atccagtgca aacctaagag attaggtgtt cccttcgggg acgctgagac aggtggtgca 1080
tggctgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 1140
tgtcattagt tgccatcatt aagttgggca ctctaatgag actgccggtg acaaaccgga 1200
ggaaggtggg gatgacgtca agtcatcatg ccccttatga cctgggctac acacgtgcta 1260
caatggacgg tacaacgaga agcgaacctg cgaaggcaag cggatctctg aaagccgttc 1320
tcagttcgga ctgtaggctg caactcgcct acacgaagct ggaatcgcta gtaatcgcgg 1380
atcagcacgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1440
gagtctgtaa cacccaaagc cggtgggata acctttatag gagtcagccg tctaaggtag 1500
gacagatgat tagggtgaag tcgtaacaag gtagccgtag gagaacctgc ggctggatca 1560
cctcctttct 1570
<210> 263
<211> 1570
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 263
tgagagtttg atcctggctc aggacgaacg ctggcggcgt gcctaataca tgcaagtcga 60
gcgagcttgc ctagatgaat ttggtgcttg caccagatga aactagatac aagcgagcgg 120
cggacgggtg agtaacacgt gggtaacctg cccaagagac tgggataaca cctggaaaca 180
gatgctaata ccggataaca acactagacg catgtctaga gtttaaaaga tggttctgct 240
atcactcttg gatggacctg cggtgcatta gctagttggt aaggtaacgg cttaccaagg 300
caatgatgca tagccgagtt gagagactga tcggccacat tgggactgag acacggccca 360
aactcctacg ggaggcagca gtagggaatc ttccacaatg gacgcaagtc tgatggagca 420
acgccgcgtg agtgaagaag ggtttcggct cgtaaagctc tgttggtagt gaagaaagat 480
agaggtagta actggccttt atttgacggt aattacttag aaagtcacgg ctaactacgt 540
gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttattg ggcgtaaagc 600
gagtgcaggc ggttcaataa gtctgatgtg aaagccttcg gctcaaccgg agaattgcat 660
cagaaactgt tgaacttgag tgcagaagag gagagtggaa ctccatgtgt agcggtggaa 720
tgcgtagata tatggaagaa caccagtggc gaaggcggct ctctggtctg caactgacgc 780
tgaggctcga aagcatgggt agcgaacagg attagatacc ctggtagtcc atgccgtaaa 840
cgatgagtgc taagtgttgg gaggtttccg cctctcagtg ctgcagctaa cgcattaagc 900
actccgcctg gggagtacga ccgcaaggtt gaaactcaaa ggaattgacg ggggcccgca 960
caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 1020
atccagtgca aacctaagag attaggtgtt cccttcgggg acgctgagac aggtggtgca 1080
tggctgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 1140
tgtcattagt tgccatcatt aagttgggca ctctaatgag actgccggtg acaaaccgga 1200
ggaaggtggg gatgacgtca agtcatcatg ccccttatga cctgggctac acacgtgcta 1260
caatggacgg tacaacgaga agcgaacctg cgaaggcaag cggatctctg aaagccgttc 1320
tcagttcgga ctgtaggctg caactcgcct acacgaagct ggaatcgcta gtaatcgcgg 1380
atcagcacgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1440
gagtctgtaa cacccaaagc cggtgggata acctttatag gagtcagccg tctaaggtag 1500
gacagatgat tagggtgaag tcgtaacaag gtagccgtag gagaacctgc ggctggatca 1560
cctcctttct 1570
<210> 264
<211> 1571
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 264
tgagagtttg atcctggctc aggacgaacg ctggcggcgt gcctaataca tgcaagtcga 60
gcgagcttgc ctagatgaat ttggtgcttg caccaaatga aactagatac aagcgagcgg 120
cggacgggtg agtaacacgt gggtaacctg cccaagagac tgggataaca cctggaaaca 180
gatgctaata ccggataaca acactagacg catgtctaga gtttaaaaga tggttctgct 240
atcactcttg gatggacctg cggtgcatta gctagttggt aaggtaacgg cttaccaagg 300
caatgatgca tagccgagtt gagagactga tcggccacat tgggactgag acacggccca 360
aactcctacg ggaggcagca gtagggaatc ttccacaatg gacgcaagtc tgatggagca 420
acgccgcgtg agtgaagaag ggtttcggct cgtaaagctc tgttggtagt gaagaaagat 480
agaggtagta actggccttt atttgacggt aattacttag aaagtcacgg ctaactacgt 540
gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttattg ggcgtaaagc 600
gagtgcaggc ggttcaataa gtctgatgtg aaagccttcg gctcaaccgg agaattgcat 660
cagaaactgt tgaacttgag tgcagaagag gagagtggaa ctccatgtgt agcggtggaa 720
tgcgtagata tatggaagaa caccagtggc gaaggcggct ctctggtctg caactgacgc 780
tgaggctcga aagcatgggt agcgaacagg attagatacc ctggtagtcc atgccgtaaa 840
cgatgagtgc taagtgttgg gaggtttccg cctctcagtg ctgcagctaa cgcattaagc 900
actccgcctg gggagtacga ccgcaaggtt gaaactcaaa ggaattgacg ggggcccgca 960
caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 1020
atccagtgca aacctaagag attaggagtt cccttcgggg acgctgagac aggtggtgca 1080
tggctgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 1140
tgtcattagt tgccatcatt aagttgggca ctctaatgag actgccggtg acaaaccgga 1200
ggaaggtggg gatgacgtca agtcatcatg ccccttatga cctgggctac acacgtgcta 1260
caatggacgg tacaacgaga agcgaacctg cgaaggcaag cggatctctg aaagccgttc 1320
tcagttcgga ctgtaggctg caactcgcct acacgaagct ggaatcgcta gtaatcgcgg 1380
atcagcacgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1440
gagtctgtaa cacccaaagc cggtgggata acctttatag gagtcagccg tctaaggtag 1500
gacagatgat tagggtgaag tcgtaacaag gtagccgtag gagaacctgc ggctggatca 1560
cctcctttct a 1571
<210> 265
<211> 1327
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 265
gagtttgatc ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg 60
agcggcggac gggtgagtaa cacgtgggta acctgcccaa gagactggga taacacctgg 120
aaacagatgc taataccgga taacaaaagt cactcttgga tggacctgcg gtgcattagc 180
tagttggtaa ggtaacggct taccaaggca atgatgcata gccgagttga gagactgatc 240
ggccacattg ggactgagac acggcccaaa ctcctacggg aggcagcagt agggaatctt 300
ccacaatgga cgcaagtctg atggagcaac gccgcgtgag tgaagaaggg tttcggctcg 360
taaagctctg ttggtagtga agatgacggt aattacttag aaagtcacgg ctaactacgt 420
gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttattg ggcgtaaagc 480
gagtgcaggc ggttcaataa gtctgatgtg aaagccttcg gctcaaccgg agaattgcat 540
cagaaactgt tgaacttgag tgcagaagag gagagtggaa ctccatgtgt agcggtggaa 600
tgcgtagata tatggaagaa caccagtggc gaaggcggct ctctggtctg actgacgctg 660
aggctcgaaa gcatgggtag cgaacaggat tagataccct ggtagtccat gccgtaaacg 720
atgagtgcta agtgttggga tctcagtgct gcagctaacg cattaagcac tccgcctggg 780
gagcacgacc gcaaggttga aactcaaagg aattgacggg ggcccgcaca agcggtggag 840
catgtggttt aattcgaagc aacgcgaaga accttaccag gtcttgacat cgacaggtgg 900
tgcatggctg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 960
cccttgtcat tagttgccat catgggcact ctaatgagac tgccggtgac aaaccggagg 1020
aaggtgggga tgacgtcaag tcatcatgcc ccttatgacc tgggctacac acgtgctaca 1080
atggacggca acgagaagcg aacctgcgaa ggcaagcgga tctctgccgt tctcagttcg 1140
gatgtaggct gcaactcgcc tacagaagct ggaatcgcta gtaatcgcgg atcagcacgc 1200
cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga gagtctgtaa 1260
cacccaaagc cggtggatag tcagccgtct aaggtaggac agatgattag ggtgaagtcg 1320
taacaag 1327
<210> 266
<211> 1219
<212> DNA
<213> Artificial Sequence
<220>
<223> Lactobacillus_gasseri
<400> 266
agcggcggac gggtgagtaa cacgtgggta acctgcccaa gagactggga taacacctgg 60
aaacagatgc taataccgga taacaaaagt cactcttgga tggacctgcg gtgcattagc 120
tagttggtaa ggtaacggct taccaaggca atgatgcata gccgagttga gagactgatc 180
ggccacattg ggactgagac acggcccaaa ctcctacggg aggcagcagt agggaatctt 240
ccacaatgga cgcaagtctg atggagcaac gccgcgtgag tgaagaaggg tttcggctcg 300
taaagctctg ttggtagtga agatgacggt aattacttag aaagtcacgg ctaactacgt 360
gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttattg ggcgtaaagc 420
gagtgcaggc ggttcaataa gtctgatgtg aaagccttcg gctcaaccgg agaattgcat 480
cagaaactgt tgaacttgag tgcagaagag gagagtggaa ctccatgtgt agcggtggaa 540
tgcgtagata tatggaagaa caccagtggc gaaggcggct ctctggtctg actgacgctg 600
aggctcgaaa gcatgggtag cgaacaggat tagataccct ggtagtccat gccgtaaacg 660
atgagtgcta agtgttggga tctcagtgct gcagctaacg cattaagcac tccgcctggg 720
gagtacgacc gcaaggttga aactcaaagg aattgacggg ggcccgcaca agcggtggag 780
catgtggttt aattcgaagc aacgcgaaga accttaccag gtcttgacat cgacaggtgg 840
tgcatggctg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa 900
cccttgtcat tagttgccat catgggcact ctaatgagac tgccggtgac aaaccggagg 960
aaggtgggga tgacgtcaag tcatcatgcc ccttatgacc tgggctacac acgtgctaca 1020
atggacggca acgagaagcg aacctgcgaa ggcaagcgga tctctgccgt tctcagttcg 1080
gatgtaggct gcaactcgcc tacagaagct ggaatcgcta gtaatcgcgg atcagcacgc 1140
cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga gagtctgtaa 1200
cacccaaagc cggtgggta 1219
<210> 267
<211> 1420
<212> DNA
<213> Artificial Sequence
<220>
<223> Oscillibacter_sp_G2
<220>
<221> misc_feature
<222> (72)..(72)
<223> n is a, c, g, or t
<400> 267
ggacctggct caggacgaac gctggcggcg tgcttaacac atgcaagtcg aacggagcac 60
ccttgaatga gntttcggyc aaaggaaagg aatgcttagt ggcggactgg tgagtaacgc 120
gtgaggaacc tgcctttcag agggggacaa cagctggaaa cggctgctaa taccgcatga 180
cgcattcgga tggcatcatc tgaatgccaa agatttatcg ctgaaagatg gcctcgcgtc 240
tgattagata gttggcgggg taacggccca ccaagtcgac gatcagtagc cggactgaga 300
ggttgaccgg ccacattggg actgagatac ggcccagact cctacgggag gcagcagtgg 360
ggaatattgg gcaatgggcg caagcctgac ccagcaacgc cgcgtgaagg aagaaggctt 420
tcgggttgta aacttctttt aagagggaag agcagaagac ggtacctctt gaataagcca 480
cggctaacta cgtgccagca gccgcggtaa tacgtaggtg gcaagcgttg tccggattta 540
ctgggtgtaa agggcgtgca gccgggtgyg caagtcagat gtgaaatctc agggctcaac 600
cctgaaactg catttgaaac tgtgygtctt gagtgccgga gaggtaatcg gaattccttg 660
tgtagcggtg aaatgcgtag atataaggaa gaacaccagt ggcgaaggcg gattactgga 720
cggtaactga cggtgaggcg cgaaagcgtg gggagcaaac aggattagat accctggtag 780
tccacgctgt aaacgatcaa tactaggtgt gcggggactg accccctgcg tgccggagtt 840
aacacaataa gtattgcacc tggggagtac gatcgcaagg ttgaaactca aaggaattga 900
cgggggcccg cacaagcggt ggattatgtg gtttaattcg aagcaacgcg agaaccttac 960
caggtcttga catcctgcta cgagtagaga tacatcaggt gcccttcggg gaaagcagag 1020
acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac 1080
gagcgcaacc cctattgtta gttgctacgc aagagcactc tagcgagact gccgttgaca 1140
aaacggagga aggtggggac gacgtcaaat catcatgccc cttatgacct gggctacaca 1200
cgtaatacaa tggcggagaa caaagggatg caaagccgcg aggcagagcg aaccccaaaa 1260
agccgtccca gttcggatcg caggctgcaa cccgcctgcg tgaagtcgga atcgctagta 1320
atcgtgggtc agcataccac ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac 1380
accatgagag tcgggaacac ccgaagtccg tagcctaacc 1420
<210> 268
<211> 1453
<212> DNA
<213> Artificial Sequence
<220>
<223> Oscillibacter_valericigenes
<400> 268
gacgaacgct ggcggcgtgc ttaacacatg caagtcgaac ggagcaccct tgattgaggt 60
ttcggccaaa tgagaggaat gcttagtggc ggactggtga gtaacgcgtg aggaacctgc 120
ctttcagagg gggacaacag ttggaaacga ctgctaatac cgcatgatac atttgggcga 180
catcgcttga atgtcaaaga tttatcgctg aaagatggcc tcgcgtctga ttagatagtt 240
ggtgaggtaa cggcccacca agtcgacgat cagtagccgg actgagaggt tgaccggcca 300
cattgggact gagatacggc ccagactcct acgggaggca gcagtgggga atattgggca 360
atggacgcaa gtctgaccca gcaacgccgc gtgaaggaag aaggctttcg ggttgtaaac 420
ttcttttaag ggggaagagt agaagacggt accccttgaa taagccacgg ctaactacgt 480
gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggatttactg ggtgtaaagg 540
gcgtgtagcc gggaaggtaa gtcagatgtg aaatctgggg gctcaacctc caaactgcat 600
ttgaaactac ttttcttgag tatcggagag gtaatcggaa ttccttgtgt agcggtgaaa 660
tgcgtagata taaggaagaa caccagtggc gaaggcggat tactggacga caactgacgg 720
tgaggcgcga aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa 780
cgatcaatac taggtgtgcg gggactgacc ccctgcgtgc cgcagttaac acaataagta 840
ttgcacctgg ggagtacgat cgcaaggttg aaactcaaag gaattgacgg gggcccgcac 900
aagcggtgga ttatgtggtt taattcgaag caacgcgaag aaccttacca ggacttgaca 960
tcctactaac gaggtagaga tacgtcaggt gcccttcggg gaaagtagag acaggtggtg 1020
catggttgtc gtcagctcgt gtcgtgagat gttgggttaa gtcccgcaac gagcgcaacc 1080
cctattgtta gttgctacgc aagagcactc tagcgagact gccgttgaca aaacggagga 1140
aggtggggac gacgtcaaat catcatgccc cttatgtcct gggctacaca cgtaatacaa 1200
tggcggtcaa cagagggatg caaagccgtg aggtggagcg aacccctaaa agccgtctca 1260
gttcggatcg caggctgcaa ctcgcctgcg tgaagtcgga atcgctagta atcgcggatc 1320
agaatgccgc ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac accatgagag 1380
tcgggaacac ccgaagtccg tagcctaaca gcaatgaggg cgcggccgaa ggtgggtttg 1440
ataattgggg tgg 1453
<210> 269
<211> 1534
<212> DNA
<213> Artificial Sequence
<220>
<223> Oscillibacter_valericigenes
<400> 269
atttatagag agtttgatcc tggctcagga cgaacgctgg cggcgtgctt aacacatgca 60
agtcgaacgg agcacccttg attgaggttt cggccaaatg agaggaatgc ttagtggcgg 120
actggtgagt aacgcgtgag gaacctgcct ttcagagggg gacaacagtt ggaaacgact 180
gctaataccg catgatacat ttgggcgaca tcgcttgaat gtcaaagatt tatcgctgaa 240
agatggcctc gcgtctgatt agatagttgg tgaggtaacg gcccaccaag tcgacgatca 300
gtagccggac tgagaggttg accggccaca ttgggactga gatacggccc agactcctac 360
gggaggcagc agtggggaat attgggcaat ggacgcaagt ctgacccagc aacgccgcgt 420
gaaggaagaa ggctttcggg ttgtaaactt cttttaaggg ggaagagtag aagacggtac 480
cccttgaata agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag 540
cgttgtccgg atttactggg tgtaaagggc gtgtagccgg gaaggtaagt cagatgtgaa 600
atctgggggc tcaacctcca aactgcattt gaaactactt ttcttgagta tcggagaggt 660
aatcggaatt ccttgtgtag cggtgaaatg cgtagatata aggaagaaca ccagtggcga 720
aggcggatta ctggacgaca actgacggtg aggcgcgaaa gcgtggggag caaacaggat 780
tagataccct ggtagtccac gctgtaaacg atcaatacta ggtgtgcggg gactgacccc 840
ctgcgtgccg cagttaacac aataagtatt gcacctgggg agtacgatcg caaggttgaa 900
actcaaagga attgacgggg gcccgcacaa gcggtggatt atgtggttta attcgaagca 960
acgcgaagaa ccttaccagg acttgacatc ctactaacga ggtagagata cgtcaggtgc 1020
ccttcgggga aagtagagac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt 1080
tgggttaagt cccgcaacga gcgcaacccc tattgttagt tgctacgcaa gagcactcta 1140
gcgagactgc cgttgacaaa acggaggaag gtggggacga cgtcaaatca tcatgcccct 1200
tatgtcctgg gctacacacg taatacaatg gcggtcaaca gagggatgca aagccgtgag 1260
gtggagcgaa cccctaaaag ccgtctcagt tcggatcgca ggctgcaact cgcctgcgtg 1320
aagtcggaat cgctagtaat cgcggatcag aatgccgcgg tgaatacgtt cccgggcctt 1380
gtacacaccg cccgtcacac catgagagtc gggaacaccc gaagtccgta gcctaacagc 1440
aatgagggcg cggccgaagg tgggtttgat aattggggtg aagtcgtaac aaggtagccg 1500
tatcggaagg tgcggctgga tcacctcctt tcta 1534
<210> 270
<211> 1450
<212> DNA
<213> Artificial Sequence
<220>
<223> Oscillospira_guilliermondii
<400> 270
gacgaacgct ggcggcgtgc ttaacacatg caagtcgaac ggagcgccaa ggaaggagtt 60
ttcggacaac ggatttggct gcttagtggc ggactggtga gtaacgcgtg aggaacctgc 120
ccttgagtgg gggacaacgg ttggaaacga ctgctaatac cgcatgatgt attgtcggga 180
catcccggcg ataccaaaga tttatcgctc aaggatggcc tcgcgtctga ttagatagtt 240
ggtgaggtaa cggctcacca agtcgacgat cagtagccgg actgagaggt tggccggcca 300
cattgggact gagatacggc ccagactcct acgggaggca gcagtgggga atattgggca 360
atggacgcaa gtctgaccca gcaacgccgc gtgaaggaag aaggctttcg ggttgtaaac 420
ttcttttaag ggggaagagc agaagacggt accccttgaa taagccacgg ctaactacgt 480
gccagcagcc gcggtaatac gtaggtggcg agcgttgtcc ggatttactg ggtgtaaagg 540
gcgtgcagcc gggtctgcaa gtcagatgtg aaatccacgg gcttaacccg tgaactgcat 600
ttgaaactgc gggtcttgag tatcggagag gtaatcggaa ttcctggtgt agcggtgaaa 660
cgcgtagata tcaggaagaa caccagtggc gaaggcggat tactggacga caactgacgg 720
tgaggcgcga aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgctgtaaa 780
cgatcaatac taggtgtgcg gggactaacc cctcgcgtgc cggagtcaac acaataagta 840
ttgcacctgg ggagtacgat cgcaaggttg aaactcaaag gaattgacgg gggcccgcac 900
aagcggtgga ttatgtggtt taattcgaag caacgcgaag aaccttacca aggcttgaca 960
tggagaggct cggcttagag ataggtcttt cccttcgggg acttctcaca caggtggtgc 1020
atggttgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc 1080
ctattgttag ttgctacgca agagcactct agcgagactg ccgttgacaa aacggaggaa 1140
ggtggggacg acgtcaaatc atcatgcccc ttatgtcttg ggctacacac gtaatacaat 1200
ggcggataca aagggatgcg aaaccgcgag gtggagcgaa ccccgaaaag ccgtctcagt 1260
tcggatcgca ggctgcaacc cgcctgcgtg aagtcggaat cgctagtaat cgtgggtcag 1320
cataccacgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac catgagagtc 1380
gggaacaccc gaagtccgta gcctaaccgc aaggggggcg cggccgaagg tgggttcgat 1440
aattggggtg 1450
<210> 271
<211> 1491
<212> DNA
<213> Artificial Sequence
<220>
<223> Papillibacter_cinnamivorans
<220>
<221> misc_feature
<222> (449)..(449)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (454)..(454)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (589)..(589)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1427)..(1427)
<223> n is a, c, g, or t
<400> 271
gatcctggct caggacgaac gctggcggcg tgcctaacac atgcaagtcg aacgaaaata 60
ccaaagcagc aatgcggggg tattttagtg gcggacgggt gagtaacgcg tgagcaatct 120
gccttttgga gggggatacc gactggaaac ggtcgttaat accgcataac gtatatggac 180
gacatcgtcc gtataccaaa ggagcaatcc gccgaaagat gagctcgcgt ctgattagct 240
agttggcggg gtaaaggccc accaaggcga cgatcagtag ccggactgag aggttgaacg 300
gccacattgg gactgagata cggcccagac tcctacggga ggcagcagtg gggaatattg 360
ggcaatgggc gaaagcctga cccagcaacg ccgcgtcaag gaagaaggcc ttcgggttgt 420
aaacttcttt taccagggaa gaagaagtnc ggtncctgga aaacaagcca cggctatcta 480
cgtgccagca gccgcggtaa tacgtaggtg gcaagcgttg tccggattta ctgggtgtaa 540
agggcgcgta ggcggcattg caagtcagat gtgaaatgcc ggggcttanc cccggagctg 600
catttgaaac tgtagagctt gagtgatgga gaggcaggcg gaattcctag tgtagcggtg 660
aaatgcgtag atattaggag gaacaccagt ggcgaaggcg gcctgctgga cattaactga 720
cgctgaggcg cgaaagcgtg gggagcaaac aggattagat accctggtag tccacgctgt 780
aaacgatgga tactaggtgt gggaggtctg accccttccg tgccggagtt aacacaataa 840
gtatcccacc tggggagtac gatcgcaagg ttgaaactca aaggaattga cgggggcccg 900
cacaagcagt ggagtatgtg gtttaattcg aagcaacgcg aagaacctta ccaggatttg 960
acatcctact aacgaggtag agatacgtca ggtgcccttc ggggaaagta gagacaggtg 1020
gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 1080
acccttattg ctagttgcta cgcaagagca ctctagcgag actgccgttg acaaaacgga 1140
ggaaggcggg gacgacgtca aatcatcatg ccccttatgt cctgggctac acacgtacta 1200
caatggcggt taacagaggg aagcaagaca gtgatgtgga gcaaatccct aaaaaccgtc 1260
tcagttcgga tcgcaggctg caacccgcct gcgtgaagtc ggaattgcta gtaatcgcgg 1320
atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1380
gagtcgggaa tacccgaagt ccgtagtcta accgcaaggg ggacgcngcc gaaggtaggt 1440
tcgataattg gggtgaagtc gtaacaaggt aaccgtatcg gaaggtgcgg c 1491
<210> 272
<211> 1497
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<400> 272
caatttaaac aacgaagagt ttgatcctgg ctcaggatga acgctagcga caggcttaac 60
acatgcaagt cgaggggcag cggggtgtag caatacaccg ccggcgaccg gcgcacgggt 120
gagtaacgcg tatgcaactt gcctatcaga gggggataac ccggcgaaag tcggactaat 180
accgcatgaa gcagggatcc cgcatgggaa tatttgctaa agattcatcg ctgatagata 240
ggcatgcgtt ccattaggca gttggcgggg taacggccca ccaaaccgac gatggatagg 300
ggttctgaga ggaaggtccc ccacattggt actgagacac ggaccaaact cctacgggag 360
gcagcagtga ggaatattgg tcaatgggcg taagcctgaa ccagccaagt cgcgtgaggg 420
atgaaggttc tatggatcgt aaacctcttt tataagggaa taaagtgcgg gacgtgtccc 480
gttttgtatg taccttatga ataaggatcg gctaactccg tgccagcagc cgcggtaata 540
cggaggatcc gagcgttatc cggatttatt gggtttaaag ggtgcgtagg cggcctttta 600
agtcagcggt gaaagtctgt ggctcaacca tagaattgcc gttgaaactg gggggcttga 660
gtatgtttga ggcaggcgga atgcgtggtg tagcggtgaa atgcatagat atcacgcaga 720
accccgattg cgaaggcagc ctgccaagcc attactgacg ctgatgcacg aaagcgtggg 780
gatcaaacag gattagatac cctggtagtc cacgcagtaa acgatgatca ctagctgttt 840
gcgatacact gtaagcggca cagcgaaagc gttaagtgat ccacctgggg agtacgccgg 900
caacggtgaa actcaaagga attgacgggg gcccgcacaa gcggaggaac atgtggttta 960
attcgatgat acgcgaggaa ccttacccgg gtttgaacgc attcggaccg aggtggaaac 1020
accttttcta gcaatagccg tttgcgaggt gctgcatggt tgtcgtcagc tcgtgccgtg 1080
aggtgtcggc ttaagtgcca taacgagcgc aacccttgcc actagttact aacaggttag 1140
gctgaggact ctggtgggac tgccagcgta agctgcgagg aaggcgggga tgacgtcaaa 1200
tcagcacggc ccttacatcc ggggcgacac acgtgttaca atggcgtgga caaagggagg 1260
ccacctggcg acagggagcg aatccccaaa ccacgtctca gttcggatcg gagtctgcaa 1320
cccgactccg tgaagctgga ttcgctagta atcgcgcatc agccatggcg cggtgaatac 1380
gttcccgggc cttgtacaca ccgcccgtca agccatggga gccgggggta cctgaagtcc 1440
gtaaccgcga ggatcggcct agggtaaaac tggtgactgg ggctaagtcg taacaag 1497
<210> 273
<211> 1323
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<400> 273
gagtttgatc ctggctcagg atgaacgcta gcgacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cgcgtatgca acttacctat cagaggggga taacccggcg 120
aaagtcggac taataccgca tgaataaagt cgctgataga taggcatgcg ttccattagg 180
cagttggcgg ggtaacggcc caccaaaccg acgatggata ggggttctga gaggaaggtc 240
ccccacattg gtactgagac acggaccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatggg cgtaagcctg aaccagccaa gtcgcgtgag ggatgaaggt ttatggatcg 360
taaacctctt ttataaggga atatgtatgt accttatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gtgcgtaggc ggccttttaa gtcagcggtg aaagtctgtg gctcaaccat agaattgccg 540
ttgaaactgg gaggcttgag tatgtttgag gcaggcggaa tgcgtggtgt agcggtgaaa 600
tgcttagata tcacgcagaa ccccgattgc gaaggcagcc tgccaagcca actgacgctg 660
atgcacgaaa gcgtggggat caaacaggat tagataccct ggtagtccac gcagtaaacg 720
atgatcacta gctgtttgcg tgtaagcggc acagcgaaag cgttaagtga tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggtttgaacg cgcgaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttgccac tagttactaa cagctgagga ctctggtggg actgccagcg taagctggag 1020
gaaggcgggg atgacgtcaa atcagcacgg cccttacatc cggggcgaca cacgtgttac 1080
aatggcgtgc aaagggaggc cacctggcga cagggagcga atcccccacg tctcagttcg 1140
gacggagtct gcaacccgac tccggaagct ggattcgcta gtaatcgcgc atcagccatg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg ggagccgggg 1260
gtacctgaag tccgtatcgg cctagggtaa aactggtgac tggggctaag tcgtaacaag 1320
gta 1323
<210> 274
<211> 1486
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<400> 274
agagtttgat cctggctcag gatgaacgct agcgacaggc ttaacacatg caagtcgagg 60
ggcagcacag gtagcaatac ccgccggcga ccggcgcacg ggtgagtaac gcgtatgcaa 120
cttgcctatc agagggggat aacccggcga aagtcggact aataccgcat gaagcagggg 180
ccccgcatgg ggatatttgc taaagattca tcgctgatag ataggcatgc gttccattag 240
gcagttggcg gggtaacggc ccaccaaacc gacgatggat aggggttctg agaggaaggt 300
cccccacatt ggtactgaga cacggaccaa actcctacgg gaggcagcag tgaggaatat 360
tggtcaatgg gcgtaagcct gaaccagcca agtcgcgtga gggatgaagg ttctatggat 420
cgtaaacctc ttttataagg gaataaagtg tgggacgtgt cctgttttgt atgtacctta 480
tgaataagga tcggctaact ccgtgccagc agccgcggta atacggagga tccgagcgtt 540
atccggattt attgggttta aagggtgcgt aggcggcctt ttaagtcagc ggtgaaagtc 600
tgtggctcaa ccatagaatt gccgttgaaa ctgggaggct tgagtatgtt tgaggcaggc 660
ggaatgcgtg gtgtagcggt gaaatgctta gatatcacgc agaaccccga ttgcgaaggc 720
agcctgccaa gccatgactg acgctgatgc acgaaagcgt ggggatcaaa caggattaga 780
taccctggta gtccacgcag taaacgatga tcactagctg tttgcgatac actgtaagcg 840
gcacagcgaa agcgttaagt gatccacctg gggagtacgc cggcaacggt gaaactcaaa 900
ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat gatacgcgag 960
gaaccttacc cgggtttgaa cgcattcgga ccgaggtgga aacacctttt ctagcaatag 1020
ccgtttgcga ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc ggcttaagtg 1080
ccataacgag cgcaaccctt gccactagtt actaacaggt gatgctgagg actctggtgg 1140
gactgccagc gtaagctgcg aggaaggcgg ggatgacgtc aaatcagcac ggcccttaca 1200
tccggggcga cacacgtgtt acaatggcgt ggacaaaggg atgccacctg gcgacaggga 1260
gcgaatcccc aaaccacgtc tcagttcgga tcggagtctg caacccgact ccgtgaagct 1320
ggattcgcta gtaatcgcgc atcagccatg gcgcggtgaa tacgttcccg ggccttgtac 1380
acaccgcccg tcaagccatg ggagccgggg gtacctgaag tccgtaaccg aaaggatcgg 1440
cctagggtaa aactggtgac tggggctaag tcgtaacaag gtaacc 1486
<210> 275
<211> 1486
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<400> 275
agagtttgat cctggctcag gatgaacgct agcgacaggc ttaacacatg caagtcgagg 60
ggcagcacag gtagcaatac cgggtggcga ccggcgcacg ggtgagtaac gcgtatgcaa 120
cttacctatc agagggggat aacccggcga aagtcggact aataccgcat gaagcagggg 180
ccccgcatgg ggatatttgc taaagattca tcgctgatag ataggcatgc gttccattag 240
gcagttggcg gggtaacggc ccaccaaacc gacgatggat aggggttctg agaggaaggt 300
cccccacatt ggtactgaga cacggaccaa actcctacgg gaggcagcag tgaggaatat 360
tggtcaatgg gcgtaagcct gaaccagcca agtcgcgtga gggatgaagg ttctatggat 420
cgtaaacctc ttttataagg gaataaagtg cgggacgtgt cccgttttgt atgtacctta 480
tgaataagga tcggctaact ccgtgccagc agccgcggta atacggagga tccgagcgtt 540
atccggattt attgggttta aagggtgcgt aggcggcctt ttaagtcagc ggtgaaagtc 600
tgtggctcaa ccatagaatt gccgttgaaa ctgggaggct tgagtatgtt tgaggcaggc 660
ggaatgcgtg gtgtagcggt gaaatgctta gatatcacgc agaaccccga ttgcgaaggc 720
agcctgccaa gccatgactg acgctgatgc acgaaagcgt ggggatcaaa caggattaga 780
taccctggta gtccacgcag taaacgatga tcactagctg tttgcgatac actgtaagcg 840
gcacagcgaa agcgttaagt gatccacctg gggagtacgc cggcaacggt gaaactcaaa 900
ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat gatacgcgag 960
gaaccttacc cgggtttgaa cgcattcgga ccgaggtgga aacacctttt ctagcaatag 1020
ccgtttgcga ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc ggcttaagtg 1080
ccataacgag cgcaaccctt gccactagtt actaacaggt aaagctgagg actctggtgg 1140
gactgccagc gtaagctgcg aggaaggcgg ggatgacgtc aaatcagcac ggcccttaca 1200
tccggggcga cacacgtgtt acaatggcgt ggacaaaggg aggccacctg gcgacaggga 1260
gcgaatcccc aaaccacgtc tcagttcgga tcggagtctg caacccgact ccgtgaagct 1320
ggattcgcta gtaatcgcgc atcagccatg gcgcggtgaa tacgttcccg ggccttgtac 1380
acaccgcccg tcaagccatg ggagccgggg gtacctgaag tccgtaaccg aaaggatcgg 1440
cctagggtaa aactggtgac tggggctaag tcgtaacaag gtaacc 1486
<210> 276
<211> 1486
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<400> 276
agagtttgat cctggctcag gatgaacgct agcgacaggc ttaacacatg caagtcgagg 60
ggcagcacag gtagcaatac cgggtggcga ccggcgcacg ggtgagtaac gcgtatgcaa 120
cttacctatc agagggggat aacccggcga aagtcggact aataccgcat gaagcagggg 180
ccccgcatgg ggatatttgc taaagattca tcgctgatag ataggcatgc gttccattag 240
gcagttggcg gggtaacggc ccaccaaacc gacgatggat aggggttctg agaggaaggt 300
cccccacatt ggtactgaga cacggaccaa actcctacgg gaggcagcag tgaggaatat 360
tggtcaatgg gcgtaagcct gaaccagcca agtcgcgtga gggatgaagg ttctatggat 420
cgtaaacctc ttttataagg gaataaagtg tgggacgtgt cccgttttgt atgtacctta 480
tgaataagga tcggctaact ccgtgccagc agccgcggta atacggagga tccgagcgtt 540
atccggattt attgggttta aagggtgcgt aggcggcctt ttaagtcagc ggtgaaagtc 600
tgtggctcaa ccatagaatt gccgttgaaa ctgggaggct tgagtatgtt tgaggcaggc 660
ggaatgcgtg gtgtagcggt gaaatgctta gatatcacgc agaaccccga ttgcgaaggc 720
agcctgccaa gccatgactg acgctgatgc acgaaagcgt ggggatcaaa caggattaga 780
taccctggta gtccacgcag taaacgatga tcactagctg tttgcgatac attgtaagcg 840
gcacagcgaa agcgttaagt gatccacctg gggagtacgc cggcaacggt gaaactcaaa 900
ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat gatacgcgag 960
gaaccttacc cgggtttgaa cgcattcgga ccgaggtgga aacacctttt ctagcaatag 1020
ccgtttgcga ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc ggcttaagtg 1080
ccataacgag cgcaaccctt gccactagtt actaacaggt aaagctgagg actctggtgg 1140
gactgccagc gtaagctgcg aggaaggcgg ggatgacgtc aaatcagcac ggcccttaca 1200
tccggggcga cacacgtgtt acaatggcgt ggacaaaggg aggccacctg gcgacaggga 1260
gcgaatcccc aaaccacgtc tcagttcgga tcggagtctg caacccgact ccgtgaagct 1320
ggattcgcta gtaatcgcgc atcagccatg gcgcggtgaa tacgttcccg ggccttgtac 1380
acaccgcccg tcaagccatg ggagccgggg gtacctgaag tccgtaaccg aaaggatcgg 1440
cctagggtaa aactggtgac tggggctaag tcgtaacaag gtaacc 1486
<210> 277
<211> 1493
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<220>
<221> misc_feature
<222> (815)..(815)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (848)..(849)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (904)..(904)
<223> n is a, c, g, or t
<400> 277
aggatgaacg ctcagcgaca ggcttaacac atgcaagtcg aggggcagcg ggggtagcaa 60
tacccgccgg cgaccggcgc acgggtgagt aacgcgtatg caacttacct atcagagggg 120
gataacccgg cgaaagtcgg actaataccg catgaagcag gggtcccgca tggggatatt 180
tgctaaagat tcatcgctga tagataggca tgcgttccat taggcagttg gcggggtaac 240
ggcccaccaa accgacgatg gatagggttc tgagaggaag gtcccccaca ttggtactga 300
gacacggacc aaactcctac gggaggcagc agtgaggaat attggtcaat gggcgtgagc 360
ctgaaccagc caagtcgcgt gagggatgaa ggttctatgg atcgtaaacc tcttttataa 420
gggaataaag tgtgggacgt gtcctatttt gtatgtacct tatgaataag gatcagccaa 480
ctccgtgcca tgcagccgcg gtaatacgga ggatccgagc gttatccgga tttattgggt 540
ttaaagggtg cgtaggcggc cttttaagtc agcggtgaaa gtctgtggct caaccataga 600
attgccgttg aaactggggg gcttgagtat gtttgaggca ggcggaatgc gtggtgtagc 660
ggtgaaatgc atagatatca cgcagaaccc cgattgcgaa ggcagcctgc caagccatta 720
ctgacgctga tgcacgagcg tgggggatcc aaccaaggag ttaaatcccc tggtagtccc 780
cccattaaac cgaataatcc taacctgktt tgscnaatac ccytgkttag ccgggmccaa 840
ccraaaannc tttaaattta tcccmccckg ggaattmccc ccggmacggk ttaaaacycc 900
aaangaattt kacgggggcc cccccaakcc gaaagaactt tttgkttaat tcgatgatac 960
gcgaggaacc ttacccgggt ttgaacgcat tcggaccgag gtggaaacac cttttctagc 1020
aatagccgtt tgcgaggtgc tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt 1080
aagtgccata acgagcgcaa cccttgccac tagttactaa caggtgatgc tgaggactct 1140
ggtgggactg ccagcgtaac tgcgaagaag cggggatgac gtcaaatcag cacgggccct 1200
tacatccggg gcgacacacg tgttacaatg gcgtggacaa agggagccac ctggcgacag 1260
ggagcgaatc cccaaaccac gtctcagttc ggatcggagt ctgcaacccg actccgtgaa 1320
gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc ccgggccttg 1380
tacacaccgc ccgtcaagcc atgggagccg ggggtacctg aagtccgtaa ccgagaggat 1440
cggcctaggg taaaactggt gactggggct aagtygtaac aaggtarcyg tam 1493
<210> 278
<211> 1442
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_distasonis
<400> 278
ggtagcaata ccgggtggcg accggcgcac gggtgagtaa cgcgtatgca acttacctat 60
cagaggggga taacccggcg aaagtcggac taataccgca tgaagcaggg gccccgcatg 120
gggatatttg ctaaagattc atcgctgata gataggcatg cgttccatta ggcagttggc 180
ggggtaacgg cccaccaaac cgacgatgga taggggttct gagaggaagg tcccccacat 240
tggtactgag acacggacca aactcctacg ggaggcagca gtgaggaata ttggtcaatg 300
ggcgtaagcc tgaaccagcc aagtcgcgtg agggatgaag gttctatgga tcgtaaacct 360
cttttataag ggaataaagt gcgggacgtg tcccgttttg tatgtacctt atgaataagg 420
atcggctaac tccgtgccag cagccgcggt aatacggagg atccgagcgt acggatttat 480
tgggtttaag ggtgcgtagg cggcctttta agtcagcggt gaaagtctgt ggctcaacca 540
tagaattgcc gttgaaactg gggggcttga gtatgtttga ggcaggcgga atgcgtggtg 600
tagcggtgaa atgcttagat atcacgcaga accccgattg cgaaggcagc ctgccaagcc 660
atgactgacg ctgatgcacg aaagcgtggg gatcaaacag gattagatac cctggtagtc 720
cacgcagtaa acgatgatca ctagctgttt gcgatacact gtaagcggca cagcgaaagc 780
gttaagtgat ccacctgggg agtacgccgg caacggtgaa actcaaagga attgacgggg 840
gcccgcacaa gcggaggaac atgtggttta attcgatgat acgcgaggaa ccttacccgg 900
gtttgaacgc attcggaccg aggtggaaac accttttcta gcaatagccg tttgcgaggt 960
gctgcatggt tgtcgtcagc tcgtgccgtg aggtgtcggc ttaagtgcca taacgagcgc 1020
aacccttgcc actagttact aacaggtaaa gctgaggact ctggtgggac tgccagcgta 1080
agctgcgagg aaggcgggga tgacgtcaaa tcagcacggc ccttacatcc ggggcgacac 1140
acgtgttaca atggcgtgga caaagggatg ccacctggcg acagggagcg aatccccaaa 1200
ccacgtctca gttcggatcg gagtctgcaa cccgactccg tgaagctgga ttcgctagta 1260
atcgcgcatc agccatggcg cggtgaatac gttcccgggc cttgtacaca ccgcccgtca 1320
agccatggga gccgggggta cctgaagtcc gtaaccgcga ggatcggcct agggtaaaac 1380
tggtgactgg ggctaagtcg taacaagtag cgtccggagc gcggaacact ctctagactg 1440
ca 1442
<210> 279
<211> 1396
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_goldsteinii
<400> 279
gtcgaggggc agcacggatg tagcaataca ttggtggcga ccggcgcacg ggtgagtaac 60
gcgtatgcaa cctgcctatc agaggggaat aacccggcga aagtcggact aataccgcat 120
aaaacagggg ttccacatgg aaatatttgt taaagaatta tcgctgatag atgggcatgc 180
gttccattag atagttggtg aggtaacggc tcaccaagtc cacgatggat aggggttctg 240
agaggaaggt cccccacact ggtactgaga cacggaccag actcctacgg gaggcagcag 300
tgaggaatat tggtcaatgg gcgagagcct gaaccagcca agtcgcgtga aggatgaagg 360
atctatggtt tgtaaacttc ttttatatgg gaataaagtg aggaacgtgt tcctttttgt 420
atgtaccata tgaataagca tcggctaact ccgtgccagc agccgcggta atacggagga 480
tgcgagcgtt atccggattt attgggttta aagggtgcgt aggtggttaa ttaagtcagc 540
ggtgaaagtt tgtggctcaa ccataaaatt gccgttgaaa ctggttgact tgagtatatt 600
tgaggtaggc ggaatgcgtg gtgtagcggt gaaatgcata gatatcacgc agaactccga 660
ttgcgaaggc agcttactaa actataactg acactgaagc acgaaagcgt ggggatcaaa 720
caggattaga taccctggta gtccacgcag taaacgatga ttactagctg tttgcgatac 780
acagtaagcg gcacagcgaa agcgttaagt aatccacctg gggagtacgc cggcaacggt 840
gaaactcaaa ggaattgacg ggggcccgca caagcggagg aacatgtggt ttaattcgat 900
gatacgcgag gaaccttacc cgggtttgaa cgcattatga cagctctgga aacacattct 960
ctagtaatag caatttgcga ggtgctgcat ggttgtcgtc agctcgtgcc gtgaggtgtc 1020
ggcttaagtg ccataacgag cgcaaccctt atcactagtt actaacaggt caagctgagg 1080
actctagtga gactgccagc gtaagctgtg aggaaggtgg ggatgacgtc aaatcagcac 1140
ggcccttaca tccggggcga cacacgtgtt acaatggtgg ggacaaaggg cagctacctg 1200
gcgacaggat gctaatctcc aaaccccatc tcagttcgga tcgaagtctg caacccgact 1260
tcgtgaagct ggattcgcta gtaatcgcgc atcagccatg gcgcggtgaa tacgttcccg 1320
ggccttgtac acaccgcccg tcaagccatg ggagttgggg gtacctaaag tccgtaaccg 1380
caaggatcgg cctagg 1396
<210> 280
<211> 1325
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_gordonii
<400> 280
gagtttgatc ctggctcagg atgaacgcta gcgacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cgcgtatgca acctacctat cagaggggga taacccggcg 120
aaagtcggac taataccgca taaataaagt tgctgataga tgggcatgcg ttccattaga 180
tagttggtaa ggtaacggct taccaagtct gcgatggata ggggttctga gaggaaggtc 240
ccccacactg gtactgagac acggaccaga ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatggg cgagagcctg aaccagccaa gtcgcgtgaa ggatgaagga ttatggttcg 360
taaacttctt ttataaggga atatgtatgt accttatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gtgcgtaggt ggtttattaa gtcagcggtg aaagtttgtg gctcaaccat aaaattgccg 540
ttgaaactgg ttaacttgag tatatttgag gtaggcggaa tgcgtggtgt agcggtgaaa 600
tgcatagata tcacgcagaa ctccaattgc gaaggcagct tactaaacta actgacactg 660
aagcacgaaa gcgtggggat caaacaggat tagataccct ggtagtccac gcagtaaacg 720
atgattacta ggagtttgcg agtaagctct acagcgaaag cgttaagtaa tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggtttgaacg cgcgaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatctt tagttactaa cagctgagga ctctaaagag actgccagcg taagctggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacatc cggggcgaca cacgtgttac 1080
aatggtgggc aaagggcagc tacacagcga tgtgatgcta atctccccca tctcagttcg 1140
gacgaagtct gcaacccgac ttcggaagct ggattcgcta gtaatcgcgc atcagccatg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg ggagttgggg 1260
gtacctaaag tccgtatcgg cctaggtaaa accgatgact ggggctaagt cgtaacaagg 1320
taacc 1325
<210> 281
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_gordonii
<400> 281
gagtttgatc ctggctcagg atgaacgcta gcgacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cgcgtatgca acctacctat cagaggggga taacccggcg 120
aaagtcggac taataccgca taaataaagt tgctgataga tgggcatgcg ttccattaga 180
tagttggtaa ggtaacggct taccaagtct gcgatggata ggggttctga gaggaaggtc 240
ccccacactg gtactgagac acggaccaga ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatggg cgagagcctg aaccagccaa gtcgcgtgaa ggatgaagga ttatggttcg 360
taaacttctt ttataaggga atatgtatgt accttatgaa taaggatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatccg agcgttatcc ggatttattg ggtttaaagg 480
gtgcgtaggt ggtttattaa gtcagcggtg aaagtttgtg gctcaaccat aaaattgccg 540
ttgaaactgg ttaacttgag tatatttgag gtaggcggaa tgcgtggtgt agcggtgaaa 600
tgcatagata tcacgcagaa ctccaattgc gaaggcagct tactaaacta actgacactg 660
aagcacgaaa gcgtggggat caaacaggat tagataccct ggtagtccac gcagtaaacg 720
atgattacta ggagtttgcg agtaagctct acagcgaaag cgttaagtaa tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggtttgaacg cgcgaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatctt tagttactaa cagctgagga ctctaaagag actgccagcg taagctggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacatc cggggcgaca cacgtgttac 1080
aatggtgggc aaagggcagc tacacagcga tgtgatgcta atctccccca tctcagttcg 1140
gacgaagtct gcaacccgac ttcggaagct ggattcgcta gtaatcgcgc atcagccatg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg ggagttgggg 1260
gtacctaaag tccgtatcgg cctagggtaa aaccgatgac tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 282
<211> 1530
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_johnsonii
<400> 282
acaacgaaga gtttgatcct ggctcaggat gaacgctagc gacaggctta acacatgcaa 60
gtcgaggggc agcatggtaa gtagcaatac ttattgatgg cgaccggcgc acgggtgagt 120
aacgcgtatg caacttacct atcagagggg gatagcccgg cgaaagtcgg attaatactc 180
cataaaacag gggttccgca tgggactatt tgttaaagat tcatcgctga tagataggca 240
tgcgttccat taggcagttg gcggggtaac ggcccaccaa accgacgatg gataggggtt 300
ctgagaggaa ggtcccccac attggtactg agacacggac caaactccta cgggaggcag 360
cagtgaggaa tattggtcaa tggccgagag gctgaaccag ccaagtcgcg tgaaggatga 420
aggatctatg gtttgtaaac ttcttttata ggggaataaa gtgtgggacg tgttccattt 480
tgtatgtacc ctatgaataa gcatcggcta actccgtgcc agcagccgcg gtaatacgga 540
ggatgcgagc gttatccgga tttattgggt ttaaagggtg cgtaggtggt aatttaagtc 600
agcggtgaaa gtttgtggct caaccataaa attgccgttg aaactgggtt acttgagtgt 660
gtttgaggta ggcggaatgc gtggtgtagc ggtgaaatgc atagatatca cgcagaactc 720
caattgcgaa ggcagcttac taaaccataa ctgacactga agcacgaaag cgtgggtatc 780
aaacaggatt agataccctg gtagtccacg cagtaaacga tgattactag gagtttgcga 840
tacacagtaa gctctacagc gaaagcgtta agtaatccac ctggggagta cgccggcaac 900
ggtgaaactc aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc 960
gatgatacgc gaggaacctt acccgggttt gaacgtagtc agaccgacct tgaaagaggt 1020
tttctagcaa tagctgatta cgaggtgctg catggttgtc gtcagctcgt gccgtgaggt 1080
gtcggcttaa gtgccataac gagcgcaacc cttatcacta gttactaaca ggttaagctg 1140
aggactctgg tgagactgcc agcgtaagct gtgaggaagg tggggatgac gtcaaatcag 1200
cacggccctt acatccgggg cgacacacgt gttacaatgg catggacaaa gggcagctac 1260
ctggcgacag gatgctaatc tctaaaccat gtctcagttc ggatcggagt ctgcaactcg 1320
actccgtgaa gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc 1380
ccgggccttg tacacaccgc ccgtcaagcc atgggagccg ggggtacctg aagtccgtaa 1440
ccgcaaggat cggcctaggg taaaactggt gactggggct aagtcgtaac aaggtagccg 1500
taccggaagg tgcggctgga acacctcctt 1530
<210> 283
<211> 545
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_merdae
<400> 283
agagtttgat cctggctcag gatgaacgct agcgacaggc ttaacacatg caagtcgagg 60
ggcagcatga tttgtagcaa tacagattga tggcgaccgg cgcacgggtg agtaacgcgt 120
atgcaactta cctatcagag ggggatagcc cggcgaagtc ggattaatac cccataaaac 180
aggggtcccg catgggaata tttgttaaag attcatcgct gatagatagg catgcggtca 240
aatcagcacg gcccttacat ccggggcgac acacgtgtta caatggcatg gacaaagggc 300
agctacctgg cgacaggatg ctaatctcca aaccatgtct cagttcggat cggagtctgc 360
aactcgactc cgtgaagctg gattcgctag taatcgcgca tcagccatgg cgcggtgaat 420
acgttcccgg gccttgtaca caccgcccgt caagccatgg gagccggggg tacctgaagt 480
ccgtaaccgc aaggatcggc ctagggtaaa actggtgact ggggctaagt cgtaacaagg 540
taacc 545
<210> 284
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_sp_D13
<400> 284
gagtttgatc ctggctcagg atgaacgcta gcgacaggct taacacatgc aagtcgaggg 60
accggcgcac gggtgagtaa cgcgtatgca acttacctat cagaggggga tagcccggcg 120
aaagtcggat taatacccca taaataaagt cgctgataga taggcatgcg ttccattagg 180
cagttggcgg ggtaacggcc caccaaaccg acgatggata ggggttctga gaggaaggtc 240
ccccacattg gtactgagac acggaccaaa ctcctacggg aggcagcagt gaggaatatt 300
ggtcaatggc cgagaggctg aaccagccaa gtcgcgtgaa ggaagaagga ttatggtttg 360
taaacttctt ttatagggga atatgtatgt accctatgaa taagcatcgg ctaactccgt 420
gccagcagcc gcggtaatac ggaggatgcg agcgttatcc ggatttattg ggtttaaagg 480
gtgcgtaggt ggtgatttaa gtcagcggtg aaagtttgtg gctcaaccat aaaattgccg 540
ttgaaactgg gttacttgag tgtgtttgag gtaggcggaa tgcgtggtgt agcggtgaaa 600
tgcatagata tcacgcagaa ctccgattgc gaaggcagct tactaaacca actgacactg 660
aagcacgaaa gcgtggggat caaacaggat tagataccct ggtagtccac gcagtaaacg 720
atgattacta ggagtttgcg tgtaagctct acagcgaaag cgttaagtaa tccacctggg 780
gagtacgccg gcaacggtga aactcaaagg aattgacggg ggcccgcaca agcggaggaa 840
catgtggttt aattcgatga tacgcgagga accttacccg ggtttgaacg tacgaggtgc 900
tgcatggttg tcgtcagctc gtgccgtgag gtgtcggctt aagtgccata acgagcgcaa 960
cccttatcac tagttactaa cagctgagga ctctggtgag actgccagcg taagctggag 1020
gaaggtgggg atgacgtcaa atcagcacgg cccttacatc cggggcgaca cacgtgttac 1080
aatggcatgc aaagggcagc tacctggtga caggatgcta atctcccatg tctcagttcg 1140
gacggagtct gcaactcgac tccggaagct ggattcgcta gtaatcgcgc atcagccatg 1200
gcgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcaagccatg ggagccgggg 1260
gtacctgaag tccgtatcgg cctagggtaa aactggtgac tggggctaag tcgtaacaag 1320
gtaacc 1326
<210> 285
<211> 1522
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_sp_NS31_3
<400> 285
gtttgatcct ggctcaggat gaacgctagc gacaggctta acacatgcaa gtcgaggggc 60
agcatgattt gtagcaatac agattgatgg cgaccggcgc acgggtgagt aacgcgtatg 120
caacttacct atcagagggg gatagcccgg cgaaagtcgg attaataccc cataaaacag 180
gggtcccgca tgggaatatt tgttaaagat tcatcgctga tagataggca tgcgttccat 240
taggcagttg gcggggtaac ggcccaccaa accgacgatg gataggggtt ctgagaggaa 300
ggtcccccac attggtactg agacacggac caaactccta cgggaggcag cagtgaggaa 360
tattggtcaa tggccgagag gctgaaccag ccaagtcgcg tgaaggaaga aggatctatg 420
gtttgtaaac ttcttttata ggggaataaa gtggaggacg tgtccttttt tgtatgtacc 480
ctatgaataa gcatcggcta actccgtgcc agcagccgcg gtaatacgga ggatgcgagc 540
gttatccgga tttattgggt ttaaagggtg cgtaggtggt gatttaagtc agcggtgaaa 600
gtttgtggct caaccataaa attgccgttg aaactgggtt acttgagtgt gtttgaggta 660
ggcggaatgc gtggtgtagc ggtgaaatgc atagatatca cgcagaactc cgattgcgaa 720
ggcagcttac taaaccataa ctgacactga agcacgaaag cgtggggatc aaacaggatt 780
agataccctg gtagtccacg cagtaaacga tgattactag gagtttgcga tacaatgtaa 840
gctctacagc gaaagcgtta agtaatccac ctggggagta cgccggcaac ggtgaaactc 900
aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc gatgatacgc 960
gaggaacctt acccgggttt gaacgtagtc tgaccggagt ggaaacactc cttctagcaa 1020
tagcagatta cgaggtgctg catggttgtc gtcagctcgt gccgtgaggt gtcggcttaa 1080
gtgccataac gagcgcaacc cttatcacta gttactaaca ggtgaagctg aggactctgg 1140
tgagactgcc agcgtaagct gtgaggaagg tggggatgac gtcaaatcag cacggccctt 1200
acatccgggg cgacacacgt gttacaatgg catggacaaa gggcagctac ctggcgacag 1260
gatgctaatc tccaaaccat gtctcagttc ggatcggagt ctgcaactcg actccgtgaa 1320
gctggattcg ctagtaatcg cgcatcagcc atggcgcggt gaatacgttc ccgggccttg 1380
tacacaccgc ccgtcaagcc atgggagccg ggggtacctg aagtccgtaa ccgcaaggac 1440
ggcctagggt aaaactggtg actggggcta agtcgtaaca aggtagccgt accggaaggt 1500
gcggctggaa cacctccttt ct 1522
<210> 286
<211> 1524
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_sp_D13
<400> 286
acaacgaaga gtttgatcct ggctcaggat gaacgctagc gacaggctta acacatgcaa 60
gtcgaggggc agcacaggta gcaataccgg gtggcgaccg gcgcacgggt gagtaacgcg 120
tatgcaactt gcctatcaga gggggataac ccggcgaaag tcggactaat accgcatgaa 180
gcaggggccc cgcatgggga tatttgctaa agattcatcg ctgatagata ggcatgcgtt 240
ccattaggca gttggcgggg taacggccca ccaaaccgac gatggatagg ggttctgaga 300
ggaaggtccc ccacattggt actgagacac ggaccaaact cctacgggag gcagcagtga 360
ggaatattgg tcaatggccg agaggctgaa ccagccaagt cgcgtgaggg atgaaggttc 420
tatggatcgt aaacctcttt tataagggaa taaagtgcgg gacgtgtccc gttttgtatg 480
taccttatga ataaggatcg gctaactccg tgccagcagc cgcggtaata cggaggatcc 540
gagcgttatc cggatttatt gggtttaaag ggtgcgtagg cggcctttta agtcagcggt 600
gaaagtctgt ggctcaacca tagaattgcc gttgaaactg gggggcttga gtatgtttga 660
ggcaggcgga atgcgtggtg tagcggtgaa atgcatagat atcacgcaga accccgattg 720
cgaaggcagc ctgccaagcc atgactgacg ctgatgcacg aaagcgtggg gatcaaacag 780
gattagatac cctggtagtc cacgcagtaa acgatgatca ctagctgttt gcgatacact 840
gtaagcggca cagcgaaagc gttaagtgat ccacctgggg agtacgccgg caacggtgaa 900
actcaaagga attgacgggg gcccgcacaa gcggaggaac atgtggttta attcgatgat 960
acgcgaggaa ccttacccgg gtttgaacgc attcggaccg aggtggaaac accttttcta 1020
gcaatagccg tttgcgaggt gctgcatggt tgtcgtcagc tcgtgccgtg aggtgtcggc 1080
ttaagtgcca taacgagcgc aacccttgcc actagttact aacaggtgat gctgaggact 1140
ctggtgggac tgccagcgta agctgcgagg aaggcgggga tgacgtcaaa tcagcacggc 1200
ccttacatcc ggggcgacac acgtgttaca atggcgtgga caaagggagg ccacctggcg 1260
acagggagcg aatccccaaa ccacgtctca gttcggatcg gagtctgcaa cccgactccg 1320
tgaagctgga ttcgctagta atcgcgcatc agccatggcg cggtgaatac gttcccgggc 1380
cttgtacaca ccgcccgtca agccatggga gccgggggta cctgaagtcc gtaaccgcga 1440
ggatcggcct agggtaaaac tggtgactgg ggctaagtcg taacaaggta gccgtaccgg 1500
aaggtgcggc tggaacacct cctt 1524
<210> 287
<211> 1481
<212> DNA
<213> Artificial Sequence
<220>
<223> Parabacteroides_sp_NS31_3
<400> 287
agagtttgat cctggctcag gatgaacgct agcgacaggc ttaacacatg caagtcgagg 60
ggcagcatag aagtagcaat actttggtgg cgaccggcgc acgggtgagt aacgcgtatg 120
caacctacct atcagagggg aataacccgg cgaaagtcgg actaataccg cataaaacag 180
gggcaccgca tggtgatatt tgttaaagaa attcgctgat agatgggcat gcgttccatt 240
aggtagttgg tgaggtaacg gctcaccaag ccgacgatgg ataggggaac tgagaggttg 300
gtcccccaca ctggtactga gacacggacc agactcctac gggaggcagc agtgaggaat 360
attggtcaat gggcgggagc ctgaaccagc caagtcgcgt gaaggaagaa ggatctatgg 420
ttcgtaaact tcttttgcag gggaataaag tgcgggacgt gtcctgtttt gtatgtaccc 480
tgagaataag gatcggctaa ctccgtgcca gcagccgcgg taatacggag gatccgagcg 540
ttatccggat ttattgggtt taaagggtgc gtaggtggtt tgataagtca gcggtgaaag 600
tttgcagctt aactgtaaaa atgccgttga aactgtcgga cttgagtgta aatgaggtag 660
gcggaatgcg tggtgtagcg gtgaaatgca tagatatcac gcagaactcc gattgcgaag 720
gcagcttact aagctacaac tgacactgaa gcacgaaagc gtggggatca aacaggatta 780
gataccctgg tagtccacgc agtaaacgat gattactagc tgtttgcgat acacagtaag 840
cggcacagcg aaagcgttaa gtaatccacc tggggagtac gccggcaacg gtgaaactca 900
aaggaattga cgggggcccg cacaagcgga ggaacatgtg gtttaattcg atgatacgcg 960
aggaacctta cccgggtttg aacgtaggga gacaggggtg gaaacatcct tttcagcaat 1020
gactgcctac gaggtgctgc atggttgtcg tcagctcgtg ccgtgaggtg tcggcttaag 1080
tgccataacg agcgcaaccc ttatttccag ttactaacag gtgatgctga ggactctgga 1140
gagactgcca gcgtaagctg tgaggaaggt ggggatgacg tcaaatcagc acggccctta 1200
catccggggc gacacacgtg ttacaatggt aaggacaaag ggcagctacc gggcgaccgg 1260
atgcgaatct ctaaacctta tctcagttcg gatcggagtc tgcaactcga ctccgtgaag 1320
ctggattcgc tagtaatcgc gcatcagcca tggcgcggtg aatacgttcc cgggccttgt 1380
acacaccgcc cgtcaagcca tgggagccgg gggtacctga agttcgtaac cgtaaggatc 1440
gacctagggt aaaactggtg actggggcta agtcgtaaca a 1481
<210> 288
<211> 1419
<212> DNA
<213> Artificial Sequence
<220>
<223> Peptostreptococcus_anaerobius
<400> 288
agcggcggac gggtgagtaa cgcgtgggta acctgcccta tacacatgga taacatactg 60
aaaagtttac taatacatga taatatatat ttacggcatc gtagatatat caaagtgtta 120
gcggtatagg atggacccgc gtctgattag ctagttggtg agataactgc ccaccaaggc 180
gacgatcagt agccgacctg agagggtgat cggccacatt ggaactgaga cacggtccaa 240
actcctacgg gaggcagcag tggggaatat tgcacaatgg gcgcaagcct gatgcagcaa 300
cgccgcgtga acgatgaagg tcttcggatc gtaaagttct gttgcagggg aagataatga 360
cggtaccctg tgaggaagcc ccggctaact acgtgccagc agccgcggta atacgtaggg 420
ggctagcgtt atccggattt actgggcgta aagggtgcgt aggtggtctt tcaagtcggt 480
ggttaaaggc tacggctcaa ccgtagttag cctccgaaac tggaagactt gagtgcagga 540
gaggaaagtg gaattcccag tgtagcggtg aaatgcgtag atattgggag gaacaccagt 600
agcgaaggcg gctttctgga ctgcaactga cactgaggca cgaaagcgtg ggtagcaaac 660
aggattagat accctggtag tccacgctgt aaacgatgag tactaggtgt cgggggttac 720
ccccctcggt gccgcagcta acgcattaag tactccgcct ggggagtacg cacgcaagtg 780
tgaaactcaa aggaattgac ggggacccgc acaagtagcg gagcatgtgg tttaattcga 840
agcaacgcga agaaccttac ctaagcttga catcccttag accggtgttt aatcacacct 900
tcccttcggg gctgaggtga caggtggtgc atggttgtcg tcagctcgtg tcgtgagatg 960
ttgggttaag tcccgcaacg agcgcaaccc ttgtctttag ttgccagcat tcagttgggc 1020
actctagaga gactgccagg gataacctgg aggaaggtgg ggatgacgtc aaatcatcat 1080
gccccttatg cttagggcta cacacgtgct acaatgggtg gtacagaggg ttgccaaacc 1140
gtgaggtgga gctaatccct taaagccatt ctcagttcgg attgtaggct gaaactcgcc 1200
tacatgaagc tggagttact agtaatcgca gatcagaatg ctgcggtgaa tgcgttcccg 1260
ggtcttgtac acaccgcccg tcacaccatg ggagtcggaa acacccgaag ccgattatcc 1320
aaccgcaagg aggaagtcgt cgaaggtggc gtcgataact ggggtgaagt cgtaacaagg 1380
tagccgtatc ggaaggtgcg gctggatcac ctcctttct 1419
<210> 289
<211> 1473
<212> DNA
<213> Artificial Sequence
<220>
<223> Peptostreptococcus_anaerobius
<220>
<221> misc_feature
<222> (64)..(64)
<223> n is a, c, g, or t
<400> 289
gatgaacgct ggcggcgtgc ctaacacatg caagtcgagc gcgtctgatt tgatgcttgc 60
attnatgaaa gatgagcggc ggacgggtga gtaacgcgtg ggtaacctgc cctatacaca 120
tggataacat actgaaaagt ttactaatac atgataatat atatttacgg catcgtagat 180
atatcaaagt gttagcggta taggatggac ccgcgtctga ttagctagtt ggtgagataa 240
ctgcccacca aggcgacgat cagtagccga cctgagaggg tgatcggcca cattggaact 300
gagacacggt ccaaactcct acgggaggca gcagtgggga atattgcaca atgggcgcaa 360
gcctgatgca gcaacgccgc gtgaacgatg aaggtcttcg gatcgtaaag ttctgttgca 420
ggggaagata atgacggtac cctgtgagga agccccggct aactacgtgc cagcagccgc 480
ggtaatacgt agggggctag cgttatccgg atttactggg cgtaaagggt gcgtaggtgg 540
tctttcaagt cggtggttaa aggctacggc tcaaccgtag ttagcctccg aaactggaag 600
acttgagtgc aggagaggaa agtggaattc ccagtgtagc ggtgaaatgc gtagatattg 660
ggaggaacac cagtagcgaa ggcggctttc tggactgcaa ctgacactga ggcacgaaag 720
cgtgggtagc aaacaggatt agataccctg gtagtccacg ctgtaaacga tgagtactag 780
gtgtcggggg ttacccccct cggtgccgca gctaacgcat taagtactcc gcctggggag 840
tacgcacgca agtgtgaaac tcaaaggaat tgacggggac ccgcacaagt agcggagcat 900
gtggtttaat tcgaagcaac gcgaagaacc ttacctaagc ttgacatccc ttagaccggt 960
gtttaatcac accttccctt cggggctgag gtgacaggtg gtgcatggtt gtcgtcagct 1020
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccttgtct ttagttgcca 1080
gcattcagtt gggcactcta gagagactgc cagggataac ctggaggaag gtggggatga 1140
cgtcaaatca tcatgcccct tatgcttagg gctacacacg tgctacaatg ggtggtacag 1200
agggttgcca aaccgtgagg tggagctaat cccttaaagc cattctcagt tcggattgta 1260
ggctgaaact cgcctacatg aagctggagt tactagtaat cgcagatcag aatgctgcgg 1320
tgaatgcgtt cccgggtctt gtacacaccg cccgtcacac catgggagtc ggaaacaccc 1380
gaagccgatt atccaaccgc aaggaggaag tcgtcgaagg tggcgtcgat aactggggtg 1440
aagtcgtaac aaggtagccg tatcggaagg tgc 1473
<210> 290
<211> 1432
<212> DNA
<213> Artificial Sequence
<220>
<223> Peptostreptococcus_stomatis
<400> 290
ctgagcaaaa ccaagcggcg gacgggtgag taacgcgtgg gtaacctgcc ctatacacat 60
ggataacata ctgaaaagtt tactaataca tgataatata tatttgcggc atcgcagata 120
tatcaaagtg ttagcggtat aggatggacc cgcgtctgat tagctagttg gtgagataac 180
tgcccaccaa ggcgacgatc agtagccgac ctgagagggt gatcggccac attggaactg 240
agacacggtc caaactccta cgggaggcag cagtggggaa tattgcacaa tgggcgaaag 300
cctgatgcag caacgccgcg tgaacgatga aggtcttcgg atcgtaaagt tctgttgcag 360
gggaagataa tgacggtacc ctgtgaggaa gccccggcta actacgtgcc agcagccgcg 420
gtaatacgta gggggctagc gttatccgga tttactgggc gtaaagggtg cgtaggtggt 480
ccttcaagtc ggtggttaaa ggctacggct caaccgtagt aagccgccga aactggagga 540
cttgagtgca ggagaggaaa gtggaattcc cagtgtagcg gtgaaatgcg tagatattgg 600
gaggaacacc agtagcgaag gcggctttct ggactgcaac tgacactgag gcacgaaagc 660
gtgggtagca aacaggatta gataccctgg tagtccacgc tgtaaacgat gagtactagg 720
tgtcgggggt tacccccctc ggtgccgcag ctaacgcatt aagtactccg cctggggagt 780
acgcacgcaa gtgtgaaact caaaggaatt gacggggacc cgcacaagta gcggagcatg 840
tggtttaatt cgaagcaacg cgaagaacct tacctaagct tgacatccct cggacaggtg 900
tttaatcaca cccttccttc gggactgagg tgacaggtgg tgcatggttg tcgtcagctc 960
gtgtcgtgag atgttgggtt aagtcccgca acgagcgcaa cccttgtctt tagttgccag 1020
cattcagttg ggcactctag agagactgcc agggataacc tggaggaagg tggggatgac 1080
gtcaaatcat catgcccctt atgcttaggg ctacacacgt gctacaatgg gtggtacaga 1140
gggttgccaa accgtgaggt ggagccaatc ccttaaagcc attctcagtt cggattgtag 1200
gctgaaactc gcctacatga agctggagtt actagtaatc gcagatcaga atgctgcggt 1260
gaatgcgttc ccgggtcttg tacacaccgc ccgtcacacc acgggagtcg gaaacacccg 1320
aagccgatta tccaaccgca aggaggaagt cgtcgaaggt ggcgtcgata actggggtga 1380
agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ct 1432
<210> 291
<211> 1296
<212> DNA
<213> Artificial Sequence
<220>
<223> Porphyromonadaceae_bacterium_NML_060648
<400> 291
caggcttaac acatgcaagt cgagggaccg gcgcacgggt gagtaacgcg tatgcaacct 60
acctatcaga ggggaataac ccggcgaaag tcggactaat accgcataaa taaagtcgct 120
gatagatggg catgcgttcc attaggtagt tggtgaggta acggctcacc aagccgacga 180
tggatagggg aactgagagg ttggtccccc acactggtac tgagacacgg accagactcc 240
tacgggaggc agcagtgagg aatattggtc aatgggcggg agcctgaacc agccaagtcg 300
cgtgaaggaa gaaggattat ggttcgtaaa cttcttttgc aggggaatat gtatgtaccc 360
tgagaataag gatcggctaa ctccgtgcca gcagccgcgg taatacggag gatccgagcg 420
ttatccggat ttattgggtt taaagggtgc gtaggtggtt tgataagtca gcggtgaaag 480
tttgcagctt aactgtaaaa atgccgttga aactgtcgga cttgagtgta aatgaggtag 540
gcggaatgcg tggtgtagcg gtgaaatgca tagatatcac gcagaactcc gattgcgaag 600
gcagcttact aagctaactg acactgaagc acgaaagcgt ggggatcaaa caggattaga 660
taccctggta gtccacgcag taaacgatga ttactagctg tttgcgagta agcggcacag 720
cgaaagcgtt aagtaatcca cctggggagt acgccggcaa cggtgaaact caaaggaatt 780
gacgggggcc cgcacaagcg gaggaacatg tggtttaatt cgatgatacg cgaggaacct 840
tacccgggtt tgaacgtacg aggtgctgca tggttgtcgt cagctcgtgc cgtgaggtgt 900
cggcttaagt gccataacga gcgcaaccct tatttycagt tactaacagc tgaggactct 960
ggagagactg ccagcgtaag ctggaggaag gtggggatga cgtcaaatca gcacggccct 1020
tacatccggg gcgacacacg tgttacaatg gtaagcaaag ggcagctacc gggcgaccgg 1080
atgcgaatct ctcttatctc agttcggacg gagtctgcaa ctcgactccg gaagctggat 1140
tcgctagtaa tcgcgcatca gccatggcgc ggtgaatacg ttcccgggcc ttgtacacac 1200
cgcccgtcaa gccatgggag ccgggggtac ctgaagttcg tatcgaccta gggtaaaact 1260
ggtgactggg gctaagtcgt aacaaggtag ccgtac 1296
<210> 292
<211> 1483
<212> DNA
<213> Artificial Sequence
<220>
<223> Pseudoflavonifractor_capillosus
<400> 292
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac ggagagctca tgacagagga 60
ttcgtccaat ggattgggtt tcttagtggc ggacgggtga gtaacgcgtg aggaacctgc 120
ctcggagtgg ggaataacag tccgaaagga ctgctaatac cgcataatgc agctgagtcg 180
catgacactg gctgccaaag atttatcgct ctgagatggc ctcgcgtctg attagctagt 240
tggcggggta acggcccacc aaggcgacga tcagtagccg gactgagagg ttggccggcc 300
acattgggac tgagacacgg cccagactcc tacgggaggc agcagtgggg aatattgggc 360
aatgggcgca agcctgaccc agcaacgccg cgtgaaggat gaaggctttc gggttgtaaa 420
cttcttttat cagggacgaa ataaatgacg gtacctgatg aataagccac ggctaactac 480
gtgccagcag ccgcggtaat acgtaggtgg caagcgttat ccggatttac tgggtgtaaa 540
gggcgtgtag gcgggactgc aagtcaggtg tgaaaaccac gggctcaacc tgtggcctgc 600
atttgaaact gtagttcttg agtgctggag aggcaatcgg aattccgtgt gtagcggtga 660
aatgcgtaga tatacggagg aacaccagtg gcgaaggcgg attgctggac agtaactgac 720
gctgaggcgc gaaagcgtgg ggagcaaaca ggattagata ccctggtagt ccacgccgta 780
aacgatggat actaggtgtg gggggactga ccccctccgt tgccgcagtt aacacaataa 840
gtatcccacc tggggagtac gatcgcaagg ttgaaactca aaggaattga cgggggcccg 900
cacaagcggt ggagtatgtg gtttaattcg aagcaacgcg aagaacctta ccagggcttg 960
acatccgact aacgaagcag agatgcatta ggtgcccttc ggggaaagtc gagacaggtg 1020
gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 1080
acccttattg ttagttgcta cgcaagagca ctctagcgag actgccgttg acaaaacgga 1140
ggaaggtggg gacgacgtca aatcatcatg ccccttatgt cctgggccac acacgtacta 1200
caatggtggt taacagaggg aagcaatgcc gcgaggtgga gcaaatccct aaaagccatc 1260
ccagttcgga ttgcaggctg aaacccgcct gtatgaagtt ggaatcgcta gtaatcgcgg 1320
atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccatga 1380
gagtcgggaa cacccgaagt ccgtagccta accgcaagga gggcgcggcc gaaggtgggt 1440
tcgataattg gggtgaagtc gtaacaaggt agccgtatcg gaa 1483
<210> 293
<211> 1480
<212> DNA
<213> Artificial Sequence
<220>
<223> Pseudoramibacter_alactolyticus
<400> 293
taagtcaaaa agaacagttt gatcatggct caggacgaac gctggcggta tgcttaacac 60
atgcaagtcg aacgagaagt tttttattga ccttcggggg atataagaga cagacagtgg 120
cgaacgggtg agtaacgcgt gggcaaccta cctatcggag cgggatagcc tcgagaaatc 180
gggagtaaaa ccgcataaca cagcagaatc gcatgacttt gctgtcaaaa ctccggtgcc 240
gatagatggg cccgcgtctg attagctagt tggtaaggta agggcttacc aaggcaacga 300
tcagtagccg gtctgagagg gcgaacggcc acactggaac tgagacacgg tccagactcc 360
tacgggaggc agcagtgggg aatattgcgc aatgggggca accctgacgc agcaataccg 420
cgtgagtgaa gaaggttttc ggatcgtaaa gctctgttat tggggaagaa gcagtgacgg 480
tacccaatga ggaagtcccg gctaactacg tgccagcagc cgcggtaata cgtaggggac 540
gagcgttgtc cggaatcact gggcgtaaag ggcgcgtagg cggttttata agtcagatgt 600
gaaaggtacc ggctcaaccg gtgacgtgca tttgaaactg taagacttga gtactgaaga 660
ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggaaga acaccggtgg 720
cgaaggcggc ttgctgggca gatactgacg ctgaggtgcg aaagcgtggg gagcgaacag 780
gattagatac cctggtagtc cacgccgtaa acgatgaata ctaggtgttg gcgaataagt 840
cagtgccgga gttaacacaa taagtattcc gcctggggag tacgaccgca aggttgaaac 900
tcaaaggaat tgacggggac ccgcacaagc agcggagcat gtggtttaat tcgaagcaac 960
gcgaagaacc ttaccaggcc ttgacatcct ctgagcgcaa tagagatatt gctttccctt 1020
cggagacaga gagacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 1080
taagtcccgc aacgagcgca acccctgtca ttagttgcca tcattgagtt gggcactcta 1140
atgagactgc cgtagacaat acggaggaag gtggggacga cgtcaaatca tcatgcccct 1200
tatggcctgg gctacacacg tgctacaatg gtctgaacaa agggaagcga aggagcgatt 1260
cggagcgaat ctcataaaac agatcccagt tcggattgca ggctgcaact cgcctgcatg 1320
aagatggagt tgctagtaat cgcggatcag aatgtcgcgg tgaatgcgtt cccgggtctt 1380
gtacacaccg cccgtcacac cacgagagtc ggtaacaccc gaagccagtg agacaaccgg 1440
aaggagtcag ctgtcgaagg tgggatcggt aattggggtg 1480
<210> 294
<211> 1297
<212> DNA
<213> Artificial Sequence
<220>
<223> Roseburia_faecis
<400> 294
gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gagtggcgga cgggtgagta 60
acgcgtgggt aacctgcctc atacaggggg ataacagttg gaaacgactg ctaataccgc 120
ataagaaaaa gtggtatgag atggacccgc gtctgattag ccagttggca gggtaacggc 180
ctaccaaagc gacgatcagt agccgacctg agagggtgac cggccacatt gggactgaga 240
cacggcccaa actcctacgg gaggcagcag tggggaatat tgcacaatgg gggaaaccct 300
gatgcagcga cgccgcgtga gcgaagaagt atttcggtat gtaaagctct atcagcaggg 360
aagatgacgg tacctgacta agaagcaccg gctaaatacg tgccagcagc cgcggtaata 420
cgtatggtgc aagcgttatc cggatttact gggtgtaaag ggagcgcagg cggtgcggca 480
agtctgatgt gaaagcccgg ggctcaaccc cggtactgca ttggaaactg tcgtactaga 540
gtgtcggagg ggtaagtgga attcctagtg tagcggtgaa atgcgtagat attaggagga 600
acaccagtgg cgaaggcggc ttactggacg aactgacgct gaggctcgaa agcgtgggga 660
gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgaatact aggtgtcggg 720
gcttcggtgc cgcagcaaac gcaataagta ttccacctgg ggagtacgtt cgcaagaatg 780
aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag 840
caacgcgaag aaccttacca agtcttgaca tcgacaggtg gtgcatggtt gtcgtcagct 900
cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccctgtcc ttagtagcca 960
gcggccgggc actctaggga gactgccagg gataacctgg aggaaggcgg ggatgacgtc 1020
aaatcatcat gccccttatg acttgggcta cacacgtgct acaatggcgt acaaagggaa 1080
gcggagccgt gaggccgagc aaatctcaaa acgtctcagt tcggatgtag tctgcaaccc 1140
gactacagaa gctggaatcg ctagtaatcg cagatcagaa tgctgcggtg aatacgttcc 1200
cgggtcttgt acacaccgcc cgtcacacca tgggagttgg aaatgcccga agtcagtacc 1260
cagggagctg ccgaaggcag gttcgataac tggggtg 1297
<210> 295
<211> 1482
<212> DNA
<213> Artificial Sequence
<220>
<223> Roseburia_intestinalis
<400> 295
ttgatcctgg ctcaggatga acgctggcgg cgtgcttaac acatgcaagt cgaacgaagc 60
actttatttg atttcttcgg aatgaagatt ttgtgactga gtggcggacg ggtgagtaac 120
gcgtgggtaa cctgcctcat acagggggat aacagttgga aacgactgct aataccgcat 180
aagcgcacag ggtcgcatga cctggtgtga aaaactccgg tggtatgaga tggacccgcg 240
tctgattagc cagttggtgg ggtaacggcc taccaaagcg acgatcagta gccgacctga 300
gagggtgacc ggccacattg ggactgagac acggcccaaa ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg ggaaaccctg atgcagcgac gccgcgtgag cgaagaagta 420
tttcggtatg taaagctcta tcagcaggga agaagaaatg acggtacctg actaagaagc 480
accggctaaa tacgtgccag cagccgcggt aatacgtatg gtgcaagcgt tatccggatt 540
tactgggtgt aaagggagcg caggcggtac ggcaagtctg atgtgaaagc ccggggctca 600
accccggtac tgcattggaa actgtcggac tagagtgtcg gaggggtaag tggaattcct 660
agtgtagcgg tgaaatgcgt agatattagg aggaacacca gtggcgaagg cggcttactg 720
gacgattact gacgctgagg ctcgaaagcg tggggagcaa acaggattag ataccctggt 780
agtccacgcc gtaaacgatg aatactaggt gtcggggagc attgctcttc ggtgccgcag 840
caaacgcaat aagtattcca cctggggagt acgttcgcaa gaatgaaact caaaggaatt 900
gacggggacc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 960
taccaagtct tgacatcccg atgacagaac atgtaatgtg ttttctcttc ggagcatcgg 1020
tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 1080
acgagcgcaa cccctattct tagtagccag cgggtmagcc gggcactcta gggagactgc 1140
cagggataac ctggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacttgg 1200
gctacacacg tgctacaatg gcgtaaacaa agggaagcga gcctgcgagg gggagcaaat 1260
ctcaaaaata acgtctcagt tcggactgca gtctgcaact cgactgcacg aagctggaat 1320
cgctagtaat cgcgaatcag aatgtcgcgg tgaatacgtt cccgggtctt gtacacaccg 1380
cccgtcacac catgggagtt ggtaatgccc gaagtcagtg acccaaccgc aaggagggag 1440
ctgccgaagc aggatcgata actggggtga agtcgtaaca ag 1482
<210> 296
<211> 1521
<212> DNA
<213> Artificial Sequence
<220>
<223> Roseburia_intestinalis
<400> 296
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gaagcacttt atttgatttc ttcggaatga agattttgtg actgagtggc ggacgggtga 120
gtaacgcgtg ggtaacctgc ctcatacagg gggataacag ttggaaacga ctgctaatac 180
cgcataagcg cacagggtcg catgacctgg tgtgaaaaac tccggtggta tgagatggac 240
ccgcgtctga ttagccagtt ggtggggtaa cggcctacca aagcgacgat cagtagccga 300
cctgagaggg tgaccggcca cattgggact gagacacggc ccaaactcct acgggaggca 360
gcagtgggga atattgcaca atgggggaaa ccctgatgca gcgacgccgc gtgagcgaag 420
aagtatttcg gtatgtaaag ctctatcagc agggaagaag aaatgacggt acctgactaa 480
gaagcaccgg ctaaatacgt gccagcagcc gcggtaatac gtatggtgca agcgttatcc 540
ggatttactg ggtgtaaagg gagcgcaggc ggtacggcaa gtctgatgtg aaagcccggg 600
gctcaacccc ggtactgcat tggaaactgt cggactagag tgtcggaggg gtaagtggaa 660
ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa caccagtggc gaaggcggct 720
tactggacga ttactgacgc tgaggctcga aagcgtgggg agcaaacagg attagatacc 780
ctggtagtcc acgccgtaaa cgatgaatac taggtgtcgg ggagcattgc tcttcggtgc 840
cgcagcaaac gcaataagta ttccacctgg ggagtacgtt cgcaagaatg aaactcaaag 900
gaattgacgg ggacccgcac aagcggtgga gcatgtggtt taattcgaag caacgcgaag 960
aaccttacca agtcttgaca tcccgatgac agaacatgta atgtgttttc tcttcggagc 1020
atcggtgaca ggtggtgcat ggttgtcgtc agctcgtgtc gtgagatgtt gggttaagtc 1080
ccgcaacgag cgcaacccct attcttagta gccagcgggt aagccgggca ctctagggag 1140
actgccaggg ataacctgga ggaaggtggg gatgacgtca aatcatcatg ccccttatga 1200
cttgggctac acacgtgcta caatggcgta aacaaaggga agcgagcctg cgagggggag 1260
caaatctcaa aaataacgtc tcagttcgga ctgcagtctg caactcgact gcacgaagct 1320
ggaatcgcta gtaatcgcga atcagaatgt cgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagttggtaa tgcccgaagt cagtgaccca accgcaagga 1440
gggagctgcc gaaggcagga tcgataactg gggtgaagtc gtaacaaggt agccgtatcg 1500
gaaggtgcgg ctggatcacc t 1521
<210> 297
<211> 1454
<212> DNA
<213> Artificial Sequence
<220>
<223> Roseburia_inulinivorans
<400> 297
ttgatcctgg ctcaggatga acgctggcgg cgtgcttaac acatgcaagt cgaacgaagc 60
acttttacag atttcttcgg aatgaagttt tagtgactga gtggcggacg ggtgagtaac 120
gcgtgggtaa cctgcctcac acagggggat aacagttgga aacggctgct aataccgcat 180
aagcgcacag taccgcatgg tacagtgtga aaaactccgg tggtgtgaga tggacccgcg 240
tctgattagc tagttggcag ggcaacggcc taccaaggcg acgatcagta gccgacctga 300
gagggtgacc ggccacattg ggactgagac acggcccaaa ctcctacggg aggcagcagt 360
ggggaatatt gcacaatggg ggaaaccctg atgcagcgac gccgcgtgag cgaagaagta 420
tttcggtatg taaagctcta tcagcaggga agaagaaatg acggtacctg actaagaagc 480
accggctaaa tacgtgccag cagccgcggt aatacgtatg gtgcaagcgt tatccggatt 540
tactgggtgt aaagggagcg caggcggaag gctaagtctg atgtgaaagc ccggggctca 600
accccggtac tgcattggaa actggtcatc tagagtgtcg gaggggtaag tggaattcct 660
agtgtagcgg tgaaatgcgt agatattagg aggaacacca gtggcgaagg cggcttactg 720
gacgataact gacgctgagg ctcgaaagcg tggggagcaa acaggattag ataccctggt 780
agtccacgcc gtaaacgatg aatactaggt gtcggaaagc acagcttttc ggtgccgccg 840
caaacgcatt aagtattcca cctggggagt acgttcgcaa gaatgaaact caaaggaatt 900
gacggggacc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 960
taccaagtct tgacatcctt ctgaccggac agtaatgtgt cctttccttc gggacagaag 1020
tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 1080
acgagcgcaa cccttatccc cagtagccag cggttcggac gggcactctg aggagactgc 1140
cagggataac ctggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacttgg 1200
gctacacacg tgctacaatg gcgtaaacaa agggaagcga gaccgtgagg tggagcaaat 1260
cccaaaaata acgtctcagt tcggactgta gtctgcaacc cgactacacg aagctggaat 1320
cgctagtaat cgcagatcag aatgctgcgg tgaatacgtt cccgggtctt gtacacaccg 1380
cccgtcacac catgggagtt ggaaatgccc gaagtcagtg acccaaccgc aaggagggag 1440
ctgcgaaggc aggt 1454
<210> 298
<211> 1526
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcaceae_bacterium_D16
<400> 298
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
ggagtgcctt tgaaagagga ttcgtccaat tgataaggtt acttagtggc ggacgggtga 120
gtaacgcgtg aggaacctgc cttggagtgg ggaataacac agtgaaaatt gtgctaatac 180
cgcataatgc agttgggccg catggctctg actgccaaag atttatcgct ctgagatggc 240
ctcgcgtctg attagctagt tggtggggta acggcccacc aaggcgacga tcagtagccg 300
gactgagagg ttggccggcc acattgggac tgagacacgg cccagactcc tacgggaggc 360
agcagtgggg aatattgggc aatgggcgca agcctgaccc agcaacgccg cgtgaaggaa 420
gaaggctttc gggttgtaaa cttcttttct tagggacgaa gcaagtgacg gtacctaagg 480
aataagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttat 540
ccggatttac tgggtgtaaa gggcgtgtag gcgggattgc aagtcagatg tgaaaaccac 600
gggctcaacc tgtggcctgc atttgaaact gtagttcttg agtactggag aggcagacgg 660
aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg gcgaaggcgg 720
tctgctggac agcaactgac gctgaggcgc gaaagcgtgg ggagcaaaca ggattagata 780
ccctggtagt ccacgctgta aacgatggat actaggtgtg gggggtctga ccccttccgt 840
gccgcagtta acacaataag tatcccacct ggggagtacg atcgcaaggt tgaaactcaa 900
aggaattgac gggggcccgc acaagcggtg gagtatgtgg tttaattcga agcaacgcga 960
agaaccttac cagggcttga catcccgagg cccggtctag agatagacct ttctcttcgg 1020
agacctcggt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga tgttgggtta 1080
agtcccgcaa cgagcgcaac ccctattgtt agttgctacg caagagcact ctagcgagac 1140
tgccgttgac aaaacggagg aaggtgggga cgacgtcaaa tcatcatgcc ccttatgtcc 1200
tgggccacac acgtactaca atggtggtta acagagggag gcaataccgc gaggtggagc 1260
aaacccctaa aagccatccc agttcggatt gcaggctgca acccgcctgc atgaagttgg 1320
aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 1380
ccgcccgtca caccatgaga gtcgggaaca cccgaagtcc gtagcctaac cgcaaggggg 1440
gcgcggccga aggtgggttc gataattggg gtgaagtcgt aacaaggtag ccgtatcgga 1500
aggtgcggct ggatcacctc ctttct 1526
<210> 299
<211> 1342
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_bromii
<220>
<221> misc_feature
<222> (503)..(503)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (792)..(793)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1025)..(1025)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1245)..(1245)
<223> n is a, c, g, or t
<400> 299
tttgatttag tttagtggcg gacgggtgag taacgcgtga gtaacctgcc ttcaagaggg 60
ggataacatt ctgaaaagaa tgctaatacc gcatgacata tcggaaccac atggttctga 120
tatcaaagat tttatcgctt gaagatggac tcgcgtccga ttagttagtt ggtgaggtaa 180
cggctcacca agaccgcgat cggtagccgg actgagaggt tgaacggcca cattgggact 240
gagacacggc ccagactcct acgggaggca gcagtggggg atattgcgca atgggggcaa 300
ccctgacgca ccaacgccgc gtgaaggatg aaggttttcg gattgtaaac ttcttttatt 360
aaggacgaaa aatgacggta cttaatgaat aagctccggc taactacgtg ccagcagccg 420
cggtaatacg tagggagcaa gcgttgtccg gatttactgg gtgtaaaggg tgcgtaggcg 480
gctttgcaag tcagatgtga aantctatgg gctcaaccca taaactgcat ttgaaactgt 540
agagcttgag tgaagtagag gcaggcggaa ttccccgtgt agcggtgaaa tgcgtagaga 600
tggggaggaa caccagtggc gaaggcggcc tgctgggctt taactgacgc tgaggcacga 660
aagcgtgggt agcaaacagg attagatacc ctggtagtcc acgctgtaaa cgatgattac 720
taggtgtgga gggtctgacc ccttccgtgc cggagttaac acaataagta atccacctgg 780
ggagtacggm cnnaargttg aaactcaaag gaattgacgg gggcccgcac aagcagtgga 840
gtatgtggtt taattcgaag caacgcgaag aaccttacca ggtcttgaca tccaactaac 900
gaagtagaga tacattaggt gcccttcggg gaaagttgag acaggtggtg catggttgtc 960
gtcagctcgt gtcgtgagat gttggkttaa gtcccgcaac gagcgcaacc cttgctatta 1020
gttgntacgc aagagcactc taataggact gccgttgaca aaacggagga aggtggggac 1080
gacgtcaaat catcatgccc cttatgacct gggctacaca cgtactacaa tggatgttaa 1140
cagagggaag caagacagtg atgtggagca aacccctaaa aacattctca gttcagattg 1200
caggctgcaa cccgcctgca tgaagatgga attgctagta atcgnggatc agaatgmcgc 1260
ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac accatgggag ccggtaatac 1320
ccgaagtcag tagtccaacc tc 1342
<210> 300
<211> 1452
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_bromii
<400> 300
gacgaacgct ggcggcgtgc ctaacacatg caagtcgaac ggaactgttt tgaaagattt 60
cttcggaatg aatttgattt agtttagtgg cggacgggtg agtaacgcgt gagtaacctg 120
ccttcaagag ggggataaca ttctgaaaag aatgctaata ccgcatgaya tatcggaacc 180
acatggttyt gatatcaaag attttatcgc ttgaagatgg actcgcgtcc gattagttag 240
ttggtgaggt aacggctcac caagaccgcg atcggtagcc ggactgagag gttgaacggc 300
cacattggga ctgagacacg gcccagactc ctacgggagg cagcagtggg ggatattgcg 360
caatgggggc aaccctgacg cagcaacgcc gcgtgaagga tgaaggtttt cggattgtaa 420
acttctttta ttaaggacga aacttgacgg tacttaatga ataagctccg gctaactacg 480
tgccagcagc cgcggtaata cgtagggagc aagcgttgtc cggatttact gggtgtaaag 540
ggtgcgtagg cggctttgca agtcagatgt gaaatctatg ggctcaaccc ataaactgca 600
tttgaaactg tagagcttga gtgaagtaga ggcaggcgga attccccgtg tagcggtgaa 660
atgcgtagag atggggagga acaccagtgg cgaaggcggc ctgctgggct ttaactgacg 720
ctgaggcacg aaagcgtggg tagcaaacag gattagatac cctggtagtc cacgctgtaa 780
acgatgatta ctaggtgtgg ggggtctgac cccttccgtg ccggagttaa cacaataagt 840
aatccacctg gggagtacgg ccgcaaggtt gaaactcaaa ggaattgacg ggggcccgca 900
caagcagtgg agtatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 960
atccaactaa cgaagtagag atacattagg tgcccttcgg ggaaagttga gacaggtggt 1020
gcatggttgt cgtcagctcg tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac 1080
ccttgctatt agttgctacg caagagcact ctaataggac tgccgttgac aaaacggagg 1140
aaggtgggga cgacgtcaaa tcatcatgcc ccttatgacc tgggctacac acgtactaca 1200
atggatgtta acagagggaa gcaagacagc gatgtggagc aaacccctaa aaacattctc 1260
agttcagatt gcaggctgca acccgcctgc atgaagatgg aattgctagt aatcgcggat 1320
cagcatgccg cggtgaatac gttcccgggc cttgtacaca ccgcccgtca caccatggga 1380
gccggtaata cccgaagtca gtagtccaac ctcgtgagga cgctgccgaa ggtaggattg 1440
gcgactgggg tg 1452
<210> 301
<211> 1446
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_hansenii
<220>
<221> misc_feature
<222> (25)..(25)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (105)..(105)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (182)..(182)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (244)..(244)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (280)..(280)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (343)..(344)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (395)..(395)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (510)..(510)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (529)..(529)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (600)..(600)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (602)..(602)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (612)..(612)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (645)..(646)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (676)..(676)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (911)..(911)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (915)..(915)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (949)..(950)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1114)..(1114)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1126)..(1127)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1177)..(1178)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1192)..(1194)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1367)..(1367)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1386)..(1387)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1424)..(1424)
<223> n is a, c, g, or t
<400> 301
gagagtttga tcctggctca ggatnaacgc tggcggcgtg cttaacacat gcaagtcgag 60
cgaagcactt atcattgact cttcggaaga tttgatattt gactnagcgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag gggaataaca gttagaaatg gctgctaatg 180
cncataagcg cacagggacc gcatggtctg gtgtgaaaaa ctgaggtggt atgagatgga 240
cccncgtctg attaggtagt tggtggggta acggcctacn aagccgacga tcagtagccg 300
gcctgagagg gtgaacggcc acattgggac tgagacacgg ccnngactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa acccngatgc agcgacgccg cgtgaaggaa 420
gaagtatctc ggtatgtaaa cttctatcag cagggaagaa aatgacggta cctgactaag 480
aagccccggc taactacgtg ccagcagccn cggtaatacg tagggggcna gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gaagagcaag tctgatgtga aaggctgggn 600
cntaacccca gnactgcatt ggaaactgtt tttctagagt gccgnngagg taagcggaat 660
tcctagtgta gcggtnaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacggt aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgaatact aggtgtcggg gtgcaaagca gttcggtgcc 840
gcagcaaacg caataagtat tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg naccngcaca agcggtggag catgtggttt aattcgaann aacgcgaaga 960
accttaccaa gtcttgacat ctgcctgacc gttccttaac cggagctttc ttcgggacag 1020
gcaagacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc 1080
gcaacgagcg caacccctat ccttagtagc cagnagtccg gctggnnact ctagggagac 1140
tgccggggat aacccggagg aaggcgggga cgacgtnnaa tcatcatgcc cnnnatgatt 1200
tgggctacac acgtgctaca atggcgtaaa caaagggaag cgaagcggtg acgcttagca 1260
aatctcaaaa ataacgtccc agttcggact gcagtctgca actcgactgc acgaagctgg 1320
aatcgctagt aatcgcgaat cagaatgtcg cggtgaatac gttcccnggt cttgtacaca 1380
ccgccnntca caccatggga gtcagtaacg cccgaagtca gtgncccaac cttatggagg 1440
gagctg 1446
<210> 302
<211> 1529
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_lactaris
<400> 302
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgag 60
cgaagcactt tgctttgatt tcttcgggat gaagagctta gtgactgagc ggcggacggg 120
tgagtaacgc gtgggtaacc tgcctcatac agggggataa cagttagaaa tgactgctaa 180
taccgcataa gaccacagca ccgcatggtg caggggtaaa aactccggtg gtatgagatg 240
gacccgcgtc tgattagtta gttggtgggg taacggccta ccaaggcgac gatcagtagc 300
cgacctgaga gggtgaccgg ccacattggg actgagacac ggcccaaact cctacgggag 360
gcagcagtgg ggaatattgc acaatggggg aaaccctgat gcagcgacgc cgcgtgagcg 420
aagaagtatt tcggtatgta aagctctatc agcagggaag aaaatgacgg tacctgacta 480
agaagccccg gctaactacg tgccagcagc cgcggtaata cgtagggggc aagcgttatc 540
cggatttact gggtgtaaag ggagcgtaga cggagcagca agtctgatgt gaaaacccgg 600
ggctcaaccc cgggactgca ttggaaactg ttgatctgga gtgccggaga ggtaagcgga 660
attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg cgaaggcggc 720
ttactggacg gtaactgacg ttgaggctcg aaagcgtggg gagcaaacag gattagatac 780
cctggtagtc cacgccgtaa acgatgacta ctaggtgtcg ggtggcaaag ccattcggtg 840
ccgcagccaa cgcaataagt agtccacctg gggagtacgt tcgcaagaat gaaactcaaa 900
ggaattgacg gggacccgca caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa 960
gaaccttacc tgctcttgac atcccggtga cggcagagta atgtctgctt ttcttcggaa 1020
caccggtgac aggtggtgca tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt 1080
cccgcaacga gcgcaacccc tatcttcagt agccagcggt aaggccgggc actctggaga 1140
gactgccagg gataacctgg aggaaggtgg ggatgacgtc aaatcatcat gccccttatg 1200
agcagggcta cacacgtgct acaatggcgt aaacaaaggg aagcgaaccc gcgagggtgg 1260
gcaaatccca aaaataacgt ctcagttcgg attgtagtct gcaactcgac tacatgaagc 1320
tggaatcgct agtaatcgcg aatcagaatg tcgcggtgaa tacgttcccg ggtcttgtac 1380
acaccgcccg tcacaccatg ggagtcagta acgcccgaag tcagtgaccc aaccgtaagg 1440
agggagctgc cgaaggtggg accgataact ggggtgaagt cgtaacaagg tagccgtatc 1500
ggaaggtgcg gctggatcac ctcctttct 1529
<210> 303
<211> 1113
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_obeum
<400> 303
agagtttgat cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac 60
gggaaacctt ttattgaagc ttcggcagat ttagctggtt tctagtggcg gacgggtgag 120
taacgcgtgg gtaacctgcc ctatacaggg ggataacaac cagaaatggt tgctaatacc 180
gcataagcgc acaggaccgc atggtccggt gtgaaaaact ccggtggtat aggatggacc 240
cgcgttggat tagccagttg gcagggtaac ggcctaccaa agcgacgatc catagccggc 300
ctgagagggt gaacggccac attgggactg agacacggcc cagactccta cgggaggcag 360
cagtggggaa tattgcacaa tgggggaaac cctgatgcag cgacgccgcg tgaaggaaga 420
agtatctcgg tatgtaaact tctatcagca gggaagatag tgacggtacc tgactaagaa 480
gccccggcta actacgtgcc agcagccgcg gtaatacgta gggggcaagc gttatccgga 540
tttactgggt gtaaagggag cgtagacgga ttagcaagtc tgatgtgaaa ggcaggggct 600
caacccctgg actgcattgg aaactgccag tcttgagtgc cggagaggta agcggaattc 660
ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagtggcgaa ggcggcttac 720
tggacggcaa ctgacgttga ggctcgaaag cgtggggagc aaacaggatt agataccctg 780
gtagtccacg ccgtaaacga tgaatactag gtgttgggga gcaaagctct tcggtgccgc 840
cgcaaacgca ttaagtattc cacctgggga gtacgttcgc aagaatgaaa ctcaaaggaa 900
ttgacgggga cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac 960
cttaccaagt cttgacatcc ctctgaccga ctcttaaccg agtctttcct tcgggacaga 1020
ggagacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg 1080
caacgagcgc aacccctatc cccagtagcc agc 1113
<210> 304
<211> 1457
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_obeum
<220>
<221> misc_feature
<222> (65)..(66)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (960)..(960)
<223> n is a, c, g, or t
<400> 304
ggcggcgtgc ttaacacatg caagtcgaac gggaaacctt tcattgaagc ttcggcagat 60
ttggnntgtt tctagtggcg gacgggtgag taacgcgtgg gtaacctgcc ttatacaggg 120
ggataacaac cagaaatggt tgctaatacc gcataagcgc acaggaccgc atggtctggt 180
gtgaaaaact ccggtggtat aagatggacc cgcgttggat tagctagttg gcagggtaac 240
ggcctaccaa ggcgacgatc catagccggc ctgagagggt gaacggccac attgggactg 300
agacacggcc cagactccta cgggaggcag cagtggggaa tattgcacaa tgggggaaac 360
cctgatgcag cgacgccgcg tgaaggaaga agtatctcgg tatgtaaact tctatcagca 420
gggaagatag tgacggtacc tgactaagaa gccccggcta actacgtgcc agcagccgcg 480
gtaatacgta gggggcaagc gttatccgga tttactgggt gtaaagggag cgtagacgga 540
ctggcaagtc tgatgtgaaa ggcgggggct caacccctgg actgcattgg aaactgttag 600
tcttgagtgc cggagaggta agcggaattc ctagtgtagc ggtgaaatgc gtagatatta 660
ggaggaacac cagtggcgaa ggcggcttac tggacggtaa ctgacgttga ggctcgaaag 720
cgtggggagc aaacaggatt agataccctg gtagtccacg ccgtaaacga tgattactag 780
gtgttgggga gcaaagctct tcggtgccgc cgcaaacgca ttaagtattc cacctgggga 840
gtacgttcgc aagaatgaaa ctcaaaggaa ttgacgggga cccgcacaag cggtggagca 900
tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaagt cttgacatcc ctctgaccgn 960
cccttaaccg gatctttcct tcgggacagg ggagacaggt ggtgcatggt tgtcgtcagc 1020
tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccctatc cccagtagcc 1080
agcagtccgg ctgggcactc tgaggagact gccagggata acctggagga aggcggggat 1140
gacgtcaaat catcatgccc cttatgattt gggctacaca cgtgctacaa tggcgtaaac 1200
aaagggaagc aagcctgcga aggtaagcaa atcccaaaaa taacgtccca gttcggactg 1260
cagtctgcaa ctcgactgca cgaagctgga atcgctagta atcgcggatc agaatgccgc 1320
ggtgaatacg ttcccgggtc ttgtacacac cgcccgtcac accatgggag tcagtaacgc 1380
ccgaagtcag tgacctaact gcaaagaagg agctgccgaa ggcgggaccg atgactgggg 1440
tgaagtcgta acaaggt 1457
<210> 305
<211> 1490
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_obeum
<400> 305
agagtttgat cctggctcag aatgaacgct gcggcgtgtt taacacatgc aagtcgaacg 60
ggaattattt tatttgaaac ttcggtcgat ttaattattc tagtggcgga cgggtgagta 120
acgcgtgggt aacctgcctt atacaggggg ataccagtca gaaatggctg ctaataccgc 180
ataagcgcac agagctgcat ggctcagtgt gaaaaactcc ggtggtataa gatggacccg 240
cgttggatta gctagttggt ggggtaacgg cccaccaagg cgacgatcca tagccggcct 300
gagagggtga acggccacat tgggactgag acacggccca gactcctacg ggaggcagca 360
gtggggaata ttgcacaatg ggggaaaccc tgatgcagcg acgccgcgtg aaggaagaag 420
tatctcggta tgtaaacttc tatcagcagg gaagatagtg acggtacctg actaagaagc 480
cccggctaac tacgtgccag cagccgcggt aatacgtagg gggcaagcgt tatccggatt 540
tactgggtgt aaagggagcg tagacggtgt ggcaagtctg atgtgaaagg catgggctca 600
acctgtggac tgcattggaa actgtcatac ttgagtgccg gaggggtaag cggaattcct 660
agtgtagcgg tgaaatgcgt agatattagg aggaacacca gtggcgaagg cggcttactg 720
gacggtaact gacgttgagg ctcgaaagcg tggggagcaa acaggattag ataccctggt 780
agtccacgcc gtaaacgatg aatactaggt gtcggggagc atggctcttc ggtgccgtcg 840
caaacgcagt aagtattcca cctggggagt acgttcgcaa gaatgaaact caaaggaatt 900
gacggggacc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 960
taccaagtct tgacatccgc ctgaccgatc cttaaccgga tctttccttc gggacaggcg 1020
agacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 1080
acgagcgcaa cccctatcct cagtagccag caagttaagt tgggcactct gtggagactg 1140
ccagggataa cctggaggaa ggcggggatg acgtcaaatc atcatgcccc ttatgatttg 1200
ggctacacac gtgctacaat ggcgtaaaca aagggaagcg agattgtgag atggagcaaa 1260
tcccaaaaat aacgtcccag ttcggactgt agtctgcaac ccgactacac gaagctggaa 1320
tcgctagtaa tcgcggatca gaatgccgcg gtgaatacgt tcccgggtct tgtacacacc 1380
gcccgtcaca ccatgggagt cagtaacgcc cgaagtcagt gacctaactg caaagaagga 1440
gctgccgaag gcgggaccga tgactggggt gaagtcgtaa caaggtaacc 1490
<210> 306
<211> 1523
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_sp_5_1_39BFAA
<400> 306
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgggaattac tttattgact tcggtggatt tgatctattt ctagtggcgg acgggtgagt 120
aacgcgtggg taacctgcct tatacagggg gataacagtc agaaatggct gctaataccg 180
cataagcgca cagagctgca tggctcagtg tgaaaaactc cggtggtata agatggaccc 240
gcgttggatt agctgttggt ggggtaacgg cccaccaagg cgacgatcca tagccggcct 300
gagagggtga acggccacat tgggactgag acacggccca gactcctacg ggaggcagca 360
gtggggaata ttgcacaatg ggggaaaccc tgatgcagcg acgccgcgtg aaggaagaag 420
tatctcggta tgtaaacttc tatcagcagg gaagatagtg acggtacctg actaagaagc 480
cccggctaac tacgtgccag cagccgcggt aatacgtagg gggcaagcgt tatccggatt 540
tactgggtgt aaagggagcg tagacggtgt ggcaagtctg atgtgaaagg catgggctca 600
acctgtggac tgcattggaa actgtcatac ttgagtgccg gaggggtaag cggaattcct 660
agtgtagcgg tgaaatgcgt agatattagg aggaacacca gtggcgaagg cggcttactg 720
gacggtaact gacgttgagg ctcgaaagcg tggggagcaa acaggattag ataccctggt 780
agtccacgcc gtaaacgatg aatactaggt gtcggggagc atggctcttc ggtgccgtcg 840
caaacgcagt aagtattcca cctggggagt acgttcgcaa gaatgaaact caaaggaatt 900
gacggggacc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 960
taccaagtct tgacatccgc ctgaccgatc cttaaccgga tctttccttc gggacaggcg 1020
agacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 1080
acgagcgcaa cccctatcct cagtagccag catttaaggt gggcactctg gggagactgc 1140
cagggataac ctggaggaag gcggggatga cgtcaaatca tcatgcccct tatgatttgg 1200
gctacacacg tgctacaatg gcgtaaacaa agggaagcga gattgtgaga tggagcaaat 1260
cccaaaaata acgtcccagt tcggactgta gtctgcaacc cgactacacg aagctggaat 1320
cgctagtaat cgcggatcag aatgccgcgg tgaatacgtt cccgggtctt gtacacaccg 1380
cccgtcacac catgggagtc agtaacgccc gaagtcagtg acctaactgc aaagaaggag 1440
ctgccgaagg cgggaccgat gactggggtg aagtcgtaac aaggtagccg tatcggaagg 1500
tgcggctgga tcacctcctt tct 1523
<210> 307
<211> 1286
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_sp_K_1
<400> 307
cctggctcag gatgaacgct ggcggcgtgc ttaacacatg caagtcgaac gagtggcgga 60
cgggtgagta acgcgtgggt aacctgcctt atacaggggg ataacagtca gaaatggctg 120
ctaataccgc ataagaaaaa gtggtataag atggacccgc gttggattag cttgttggtg 180
gggtaacggc ccaccaaggc gacgatccat agccggcctg agagggtgaa cggccacatt 240
gggactgaga cacggcccag actcctacgg gaggcagcag tggggaatat tgcacaatgg 300
gggaaaccct gatgcagcga cgccgcgtga aggaagaagt atctcggtat gtaaacttct 360
atcagcaggg aagatgacgg tacctgacta agaagccccg gctaactacg tgccagcagc 420
cgcggtaata cgtagggggc aagcgttatc cggatttact gggtgtaaag ggagcgtaga 480
cggtgtggca agtctgatgt gaaaggcatg ggctcaacct gtggactgca ttggaaactg 540
tcatacttga gtgccggagg ggtaagcgga attcctagtg tagcggtgaa atgcgtagat 600
attaggagga acaccagtgg cgaaggcggc ttactggacg gactgacgtt gaggctcgaa 660
agcgtgggga gcaaacagga ttagataccc tggtagtcca cgccgtaaac gatgaatact 720
aggtgtcggg gcttcggtgc cgtcgcaaac gcagtaagta ttccacctgg ggagtacgtt 780
cgcaagaatg aaactcaaag gaattgacgg ggacccgcac aagcggtgga gcatgtggtt 840
taattcgaag caacgcgaag aaccttacca agtcttgaca tcgacaggtg gtgcatggtt 900
gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccctatcc 960
tcagtagcca gcatgtgggc actctgggga gactgccagg gataacctgg aggaaggcgg 1020
ggatgacgtc aaatcatcat gccccttatg atttgggcta cacacgtgct acaatggcgt 1080
acaaagggaa gcgagattgt gagatggagc aaatcccaaa acgtcccagt tcggatgtag 1140
tctgcaaccc gactacagaa gctggaatcg ctagtaatcg cggatcagaa tgccgcggtg 1200
aatacgttcc cgggtcttgt acacaccgcc cgtcacacca tgggagtcag taacgcccga 1260
agtcagtacc taaggagctg ccgaag 1286
<210> 308
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_torques
<400> 308
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cctaacacat gcaagtcgag 60
cgaagcactt tgcttagatt cttcggatga agaggattgt gactgagcgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataaga ccacagcacc gcatggtgcg ggggtaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attagctagt tggtaaggta acggcttacc aaggcgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgaa 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gatgggcaag tctgatgtga aaacccgggg 600
ctcaaccccg ggactgcatt ggaaactgtt catctagagt gctggagagg taagtggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacagt aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg tggcaaagcc attcggtgcc 840
gcagcaaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg ctcttgacat cccgctgacc ggacggtaat gcgtccttcc cttcggggca 1020
gcggagacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
ccgcaacgag cgcaacccct atctttagta gccagcggcc aggccgggca ctctagagag 1140
actgccgggg ataacccgga ggaaggtggg gatgacgtca aatcatcatg ccccttatga 1200
gcagggctac acacgtgcta caatggcgta aacaaaggga agcgagaccg cgaggtggag 1260
caaatcccaa aaataacgtc tcagttcgga ttgtagtctg caactcgact acatgaagct 1320
ggaatcgcta gtaatcgcga atcagaatgt cgcggtgaat acgttcccgg gtcttgtaca 1380
caccgcccgt cacaccatgg gagtcagtaa cgcccgaagt cagtgaccca accgtaagga 1440
gggagctgcc gaaggcggga ccgataactg gggtgaagtc gtaacaaggt agccgtatcg 1500
gaaggtgcgg ctggatcacc tcctttct 1528
<210> 309
<211> 1527
<212> DNA
<213> Artificial Sequence
<220>
<223> Ruminococcus_torques
<400> 309
gagagtttga tcctggctca ggatgaacgc tggcggcgtg cttaacacat gcaagtcgaa 60
cgaagcacct tgatttgatt cttcggatga agatcctggt gactgagtgg cggacgggtg 120
agtaacgcgt gggtaacctg cctcatacag ggggataaca gttagaaatg actgctaata 180
ccgcataaga ccacagcacc gcatggtgca ggggtaaaaa ctccggtggt atgagatgga 240
cccgcgtctg attaggtagt tggtggggta acggcctacc aagccgacga tcagtagccg 300
acctgagagg gtgaccggcc acattgggac tgagacacgg cccaaactcc tacgggaggc 360
agcagtgggg aatattgcac aatgggggaa accctgatgc agcgacgccg cgtgagcgat 420
gaagtatttc ggtatgtaaa gctctatcag cagggaagaa aatgacggta cctgactaag 480
aagcaccggc taaatacgtg ccagcagccg cggtaatacg tatggtgcaa gcgttatccg 540
gatttactgg gtgtaaaggg agcgtagacg gagtggcaag tctgatgtga aaacccgggg 600
ctcaaccccg ggactgcatt ggaaactgtc aatctggagt accggagagg taagcggaat 660
tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg aaggcggctt 720
actggacggt aactgacgtt gaggctcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgccgtaaac gatgactact aggtgtcggg cagcaaagct gttcggtgcc 840
gcagcaaacg caataagtag tccacctggg gagtacgttc gcaagaatga aactcaaagg 900
aattgacggg gacccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 960
accttacctg ctcttgacat ctccctgacc ggcaagtaat gttgcctttc cttcgggaca 1020
gggatgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 1080
cgcaacgagc gcaaccccta tctttagtag ccagcggtca ggccgggcac tctagagaga 1140
ctgccaggga taacctggag gaaggtgggg atgacgtcaa atcatcatgc cccttatgag 1200
cagggctaca cacgtgctac aatggcgtaa acaaagggag gcagaaccgc gaggtcgagc 1260
aaatcccaaa aataacgtct cagttcggat tgtagtctgc aactcgacta catgaagctg 1320
gaatcgctag taatcgcgaa tcagaatgtc gcggtgaata cgttcccggg tcttgtacac 1380
accgcccgtc acaccatggg agtcagtaac gcccgaagtc agtgacccaa ccgtaaggag 1440
ggagctgccg aaggtgggac cgataactgg ggtgaagtcg taacaaggta gccgtatcgg 1500
aaggtgcggc tggatcacct cctttct 1527
<210> 310
<211> 1506
<212> DNA
<213> Artificial Sequence
<220>
<223> Sporobacter_termitidis
<220>
<221> misc_feature
<222> (361)..(361)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (377)..(377)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (863)..(863)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1094)..(1094)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1104)..(1104)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (1110)..(1110)
<223> n is a, c, g, or t
<400> 310
agagtttgat cctggctcag gacgaacgct ggcggcgtgc ctaacacatg caagtcgaac 60
ggagacaatt ggttcgctga ttgtcttagt ggcggacggg tgagtaacgc gtgagcaatc 120
tgcccttcgg agggggacaa cagctggaaa cggctgctaa taccgcataa tgtatattca 180
aggcatcttg gatataccaa agatttatcg ccgaaggatg agctcgcgtc tgattagcta 240
gttggtgagg taaaggctca ccaaggctgc gatcagtagc cggactgaga ggttgaacgg 300
ccacattgga actgagatac gggccagact cctacgggag ggagcagtgg ggaattttgg 360
ncaatggggg aaagccntac ccagcaacgc cgcgtgaagg aagaaggcct tcgggttgta 420
aacttctttg accagggacg aaacaaatga cggtacctgg aaaacaagcc acggctaact 480
acgtgccagc agccgcggta ttacgtaggt ggcaagcgtt gtccggattt actgggtgta 540
aagggcgcgt aggcgggagt acaagtcaga tgtgaaatct gggggcttaa ccctcaaact 600
gcatttgaaa ctgtatttct tgagtatcgg agaggcaggc ggaattccta gtgtagcggt 660
gaaatgcgtt gatattagga ggaacaccag tggcgaaggc ggcctgctgg acgacaactg 720
actctgaggc gcgaaagcgt ggggagcaaa caggattaga taccctggta gtccacgctg 780
taaacgatga atactaggtg tggggggact gaccccctcc gtgccggagt taacacaata 840
agtattccac ctggggagta cgnccgcaag gttgaaactc aaaggaattg acgggggccc 900
gcacaagcag tggattatgt ggtttaattc gaagcaacgc gaagaacctt accagggctt 960
gacatcgtac taacgaagca gagatgcatt aggtgccctt ccggggaaag tatagacagg 1020
tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg 1080
caacccctat tgtnatttgc tacncgagan cactctagcg aggctgccga tgacaaaccg 1140
gaggaaggtg gggacgacgt caaatcatca tgccccttat gtcctgggct acacacgtaa 1200
tacaatgtct ctcacagagg gaagcaagac cgcgaggtgg agcaaatccc taaaatgcgt 1260
ctcagttcag attgcaggct gcaactcgcc tgcatgaagt cggaattgct agtaatcgcg 1320
gatcagcatg ccgcggtgaa tacgttcccg ggccttgtac acaccgcccg tcacaccatg 1380
agagccggga acacccgaag tccgtagtct aaccgcaagg gggacgcggc cgaaggtggg 1440
tttggtaatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac 1500
ctcctt 1506
<210> 311
<211> 1517
<212> DNA
<213> Artificial Sequence
<220>
<223> Tannerella_sp_6_1_58FAA
<400> 311
agagtttgat cctggctcag gatgaacgct agcgacaggc ctaacacatg caagtcgagg 60
ggcaacatgg tatcagcttg ctgataccga tggcgaccgg cgcacgggtg agtaacgcgt 120
atgtaatcta cctgtaacag agggataacc cggagaaatc cggactaata cctcatagca 180
catattattc gcatgaattt tatgttaaag agactcggtt acagatgaac atgcgttcca 240
ttagctggtt ggcggggtca cggcccacca aggcaacgat ggataggggt tctgagagga 300
aggtccccca cactggtact gagacacgga ccagactcct acgggaggca gcagtgagga 360
atattggtca atgggcgaag cctgaaccag ccaagtcgcg tggaggaaga cggccctacg 420
ggttgtaaac tccttttacc tgggaataac gggcgctacg tgtagcgctg tgcatgtacc 480
gggagaataa gcatcggcta attccgtgcc agcagccgcg gtaatacgga agatgcgagc 540
gttatccgga tttattgggt ttaaagggtg cgtaggcgga aggataagtc agcggtgaaa 600
tgcttcagct caactggaga attgccgatg aaactgtttt tctagagtat aaaagaggta 660
tgcggaatgc gtggtgtagc ggtgaaatgc atagatatca cgcagaaccc cgattgcgaa 720
ggcagcatac tgggctataa ctgacgctga agcacgaaag cgtgggtatc gaacaggatt 780
agataccctg gtagtccacg ccgtaaacga tgaatactaa ctgtttgcga tataatgtaa 840
gcggtacagc gaaagcgtta agtattccac ctggggagta cgccggcaac ggtgaaactc 900
aaaggaattg acgggggccc gcacaagcgg aggaacatgt ggtttaattc gatgatacgc 960
gaggaacctt acccgggctc aaacgacagg ggaataatcc cgaaaaggat tagccagcaa 1020
tggccgctgt cgaggtgctg catggttgtc gtcagctcgt gccgtgaggt gtcggcttaa 1080
gtgccataac gagcgcaacc cttaccggta gttactaaca ggtcaagctg aggactctac 1140
cgggactgcc agcgcaagct gtgaggaagg tggggatgac gtcaaatcag cacggccctt 1200
acgtccgggg cgacacacgt gttacaatgg caggtacaga gagtcgcggc gtagcaatac 1260
gtagccaatc ccgaaaaacc tgtctcagtt cggatcggag tctgcaaccc gactccgtga 1320
agctggattc gctagtaatc gcgcatcagc catggcgcgg tgaatacgtt cccgggcctt 1380
gtacacaccg cccgtcaagc catgggagcc gggagtacct gaagtatgca accgcaagga 1440
gcgtcctagg gtaatactgg tgactggggc taagtcgtaa caaggtagcc gtaccggaag 1500
gtgcggctgg aacacct 1517
Claims (33)
- 복수의 생존가능한 박테리아를 포함하는 제형으로서, 상기 제형은 일차 담즙산 또는 담즙산염 가수분해효소 활성을 나타낼 수 있는 적어도 하나의 박테리아 OTU 또는 종 및 약제학적으로 허용가능한 부형제를 포함하는, 제형.
- 청구항 1에 있어서, OTU 또는 종의 16S rDNA 서열 또는 이의 단편이 도 16의 서열 또는 이의 부분과 적어도 95% 또는 적어도 97% 동일한, 제형.
- 청구항 1에 있어서, 일차 담즙산 또는 담즙산염 가수분해효소적 활성과 상이한 특이성을 갖는 이차 담즙산 또는 담즙산염 가수분해효소적 활성, 탈접합, 산화 및 디하이드록실화로 구성된 군으로부터 선택된 활성을 나타낼 수 있는 적어도 하나의 생존가능한 박테리아 OTU 또는 종을 추가로 포함하는, 제형.
- 청구항 1 내지 3 중 어느 한 항에 있어서, 제형은 적어도 2개의 상이한 박테리아 OTU 또는 종을 포함하는, 제형.
- 청구항 1에 있어서, 상기 제형이 2개의 상이한 박테리아 OTU 또는 종을 포함하고, 제형이 산화 및 디하이드록실화 활성을 나타낼 수 있는, 제형.
- 청구항 1 내지 5 중 어느 한 항에 있어서, 상기 제형이 표 1의 적어도 2개의 분기군으로부터 선택된 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 45 또는 50개의 OTU 또는 박테리아 종을 포함하는, 제형.
- 청구항 6에 있어서, 표 1의 조성물의 각각의 OTU 또는 박테리아 종의 16S rDNA가 도 16의 적어도 하나의 서열, 또는 이의 부분과 적어도 95% 또는 97% 서열 동일성을 갖는, 제형.
- 청구항 1 내지 7 중 어느 한 항에 있어서, 제형은 표 2의 적어도 2개의 분기군으로부터 선택된 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40 또는 50개의 OTU 또는 박테리아 종을 포함하는, 제형.
- 청구항 1 내지 8 중 어느 한 항에 있어서, 제형은 표 1, 표 2 또는 표 3의 B 또는 C 부분의 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 또는 50개의 OTU 또는 박테리아 종을 포함하는, 제형.
- 청구항 1 내지 9 중 어느 한 항에 있어서, 제형은 1, 6, 86, 87, 90, 100, 101, 164, 195, 196, 197, 203, 204, 및 297 로 구성된 군으로부터 선택된 5, 10, 15, 또는 20개의 분기군으로부터의 하나 이상의 OTU 또는 박테리아 종을 포함하는, 제형.
- 청구항 1 내지 10 중 어느 한 항에 있어서, 제형내 상이한 OTU 또는 종의 수는 60, 50, 30, 20 또는 15 미만인, 제형.
- 청구항 1 내지 11 중 어느 한 항에 있어서, 제형의 하나 이상의 박테리아 OTU 또는 종의 담즙산염 가수분해효소, 탈접합, 산화 또는 디하이드록실화 활성은 동물-기반 검정, 세포-기반 검정, 시험관내 검정, 서열분석, 또는 이들 유형의 검정의 조합을 사용하여 검출되는, 제형.
- 청구항 1 내지 12 중 어느 한 항에 있어서, 제형의 각각의 박테리아 OTU 또는 종은 가수분해, 탈접합, 산화 또는 디하이드록실화로 구성된 군으로부터 선택된 담즙산 또는 담즙산염 대사 활성을 갖는, 제형.
- 청구항 1 내지 13 중 어느 한 항의 제형을 포함하는 치료적 제형.
- 청구항 13에 있어서, 생존가능한 박테리아는 소장, 결장 또는 둘 모두에 전달되는, 치료적 제형.
- 담즙정체성 질환 또는 병태로 진단되거나 또는 위험에 처한 대상체를 치료하는 방법으로서, 상기 방법은 대상체에게 미생물 조성물을 투여하는 단계를 포함하며, 미생물 조성물내의 적어도 하나의 박테리아 OTU 또는 종은 일차 담즙산 또는 담즙산염을 탈접합시킬 수 있는, 방법.
- 청구항 16에 있어서, 미생물 조성물내의 적어도 하나의 OTU 또는 박테리아 종은 일차 담즙산 또는 염을 이차 담즙산 또는 염으로 대사작용할 수 있는, 방법.
- 청구항 16 또는 17에 있어서, OTU의 16S rDNA 서열은 도 16의 서열 또는 이의 부분과 적어도 95% 동일한(예를 들어, 적어도 98%, 적어도 99%, 또는 100% 동일한), 방법.
- 담즙정체성 질환 또는 병태로 진단되거나 위험에 처한 대상체를 치료하는 방법으로서, 청구항 1 내지 15 중 어느 한 항의 제형을 상기 대상체에게 투여하는 단계를 포함하는, 방법.
- 청구항 16 내지 19 중 어느 한 항에 있어서, 상기 대상체는 일반적인 담즙정체증(GC), 일차 경화 간경변(PSC), 원발성 담도 간경변증(PBS), 진행성 가족성 간내 답증정체증(PFIC), 비-알코올성 지방 간 질환(NAFLD), 비-알코올성 지방간염(NASH), 임신 담즙정체증, 담관염, 간염, 알코올성 간 질환, 간세포 암종, 간경변증, 낭포성 섬유증, 이식편 대 숙주 질환(GVHD) 또는 간외 담관 막힘으로 진단되거나 위험에 처해있는, 방법.
- 청구항 20에 있어서, 간외 담관의 막힘은 담석, 염증성 협착, 암 또는 췌장염으로 인한 것인, 방법.
- 담즙정체성 질환 또는 병태로 진단되거나 위험에 처하여, 오베티콜산(OCA), 우르소데옥시콜산(UDCA), 또는 오베티콜산 또는 UDCA의 유도체가 처방된 대상체를 치료하는 방법으로서, 상기 방법은 상기 대상체에게 하기를 투여하는 단계를 포함하는, 방법:
(i) CDCA, BSH 활성을 갖는 박테리아, 또는 하나의 활성 및/또는 활성의 둘 모두를 억제할 수 있는 화합물 중 하나 이상을 포함하는 조성물; 및
(ii) 약제학적으로 허용가능한 부형제. - 히오콜산(hyocholic acid) 또는 히오콜산의 농도를 증가시킬 수 있는 박테리아를 함유하는 조성물.
- 담즙정체성 질환 또는 병태로 진단되거나 위험에 처한 대상체를 치료하는 방법으로서, 상기 방법은 상기 대상체에게 UDCA 및, BSH 활성을 갖지만 리토콜린산(LCA) 수준을 증가시키지는 않는 박테리아를 포함하는 조성물을 투여하는 단계를 포함하는, 방법.
- 청구항 24에 있어서, 조성물은 일차 담즙산 또는 염을 이차 담즙산 또는 염으로 대사작용할 수 있는 박테리아를 추가로 포함하는, 방법.
- 치료되는 대상체를 UDCA로 치료하는데 사용하기 위한, BSH 활성을 갖는 박테리아를 포함하는 조성물로서, 상기 박테리아는 LCA 수준을 증가시키지 않는, 조성물.
- 청구항 26에 있어서, 조성물은 일차 담즙산 또는 염을 이차 담즙산 또는 염으로 대사작용할 수 있는 박테리아를 추가로 포함하는, 조성물.
- 청구항 16 내지 22, 24, 및 25 중 어느 한 항에 있어서, 상기 대상체에게 OCA를 투여하는 단계를 추가로 포함하는, 방법.
- 청구항 16 내지 22, 24, 및 25 중 어느 한 항에 있어서, 미생물 조성물은 인간 배설물로부터 직접 유래되거나, 설계된 조성물이거나, 박테리아 포자를 포함하거나, 포자 형성 박테리아를 포함하는, 방법.
- 담즙정체성 질환 또는 병태로 진단되거나 위험에 처한 대상체를 치료하는데 사용하기 위한, 청구항 1 내지 15 중 어느 한 항의 제형을 포함하는 조성물.
- 대상체에서 담즙산 대사를 변경시키기 위한 조성물에 사용하기 위한 박테리아 종을 확인하는 방법으로서, 상기 방법은 원하는 담즙산 활성을 촉매하는 단백질의 데이터베이스에서 박테리아 균주의 단백질 코딩 서열을 참조 서열과 비교하는 단계를 포함하며, 여기서 참조 서열과 상동성을 갖는 서열을 포함하는 박테리아 균주의 확인은 조성물에 사용하기 위한 박테리아 균주의 확인을 나타내는, 방법.
- 청구항 31에 있어서, 시험관내 검정 또는 동물 모델-기반 검정을 사용하여 박테리아 종의 담즙산 대사 활성을 시험하는 단계를 추가로 포함하는, 방법.
- 청구항 31 또는 32에 있어서, 서열 상동성 수준은 적어도 75%, 80%, 85%, 90%, 93%, 95%, 97%, 98%, 99%, 또는 100% 동일성인, 방법.
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| WO2019046646A1 (en) | 2017-08-30 | 2019-03-07 | Whole Biome Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS |
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| AU2017234120B2 (en) | 2016-03-14 | 2024-06-20 | Holobiome, Inc. | Modulation of the gut microbiome to treat mental disorders or diseases of the central nervous system |
| KR20240110077A (ko) | 2017-08-14 | 2024-07-12 | 세레스 테라퓨틱스, 인코포레이티드 | 담즙정체성 질환 치료를 위한 조성물 및 방법 |
| CA3077692A1 (en) | 2017-10-03 | 2019-04-11 | Seres Therapeutics, Inc. | Manipulation of tryptamine metabolism |
| BR112020008552A2 (pt) | 2017-10-30 | 2020-12-29 | Seres Therapeutics, Inc. | métodos e composições para tratamento de resistência a antibiótico |
| WO2019191694A1 (en) | 2018-03-29 | 2019-10-03 | Seres Therapeutics, Inc. | Compositions and methods for treating inflammatory bowel diseases |
| MX2020012602A (es) | 2018-05-24 | 2021-03-31 | Seres Therapeutics Inc | Composiciones bacterianas dise?adas y usos de las mismas. |
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2018
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- 2018-08-14 CA CA3072206A patent/CA3072206A1/en active Pending
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| EP3668527A1 (en) | 2020-06-24 |
| US11701394B2 (en) | 2023-07-18 |
| US20210008128A1 (en) | 2021-01-14 |
| JP2020530840A (ja) | 2020-10-29 |
| US20240173367A1 (en) | 2024-05-30 |
| RU2020110462A (ru) | 2021-09-16 |
| WO2019036510A1 (en) | 2019-02-21 |
| MX2020001774A (es) | 2020-09-09 |
| JP2023113626A (ja) | 2023-08-16 |
| KR102680943B1 (ko) | 2024-07-03 |
| AU2018318132A1 (en) | 2020-02-27 |
| BR112020002992A2 (pt) | 2020-08-18 |
| CN111212655A (zh) | 2020-05-29 |
| CA3072206A1 (en) | 2019-02-21 |
| KR20200040277A (ko) | 2020-04-17 |
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