KR20170072565A - Micelle composition for cosmetic - Google Patents

Abstract

The present invention relates to a micelle composition for cosmetics and a method for producing the same. In one embodiment, the micelle composition for cosmetics comprises micelles dispersed in a stabilizing portion, and the micelle comprises a capsule and a core carried in the capsule, wherein the core is composed of a fatty acid, an aliphatic alcohol, an oil mixture, Wherein the encapsulant comprises a phospholipid and a second surfactant, wherein the stabilizing moiety comprises a polyol, water and a poloxamer, wherein the oil mixture is selected from the group consisting of a hydrocarbon-based oil, an ester-based oil, a silicone- Wherein the natural oil is selected from the group consisting of artemisia annua oil, papaya seed oil, pumpkin seed oil, pomegranate seed oil, tomato seed oil, oil, and curry leaf oil.

Description

MICELLE COMPOSITION FOR COSMETIC}

The present invention relates to a micelle composition for cosmetics.

Polymeromes are sphere types in which molecules with different hydrophobicity and hydrophilicity are made through self-assembly. A diblock copolymer has a self-assembled spherical structure in the form of a core-capsule comprising hydrophilic molecules and hydrophobic molecules in one molecule as the simplest structure of the polymer. The size of the spherical particles formed by self-assembling the diblock copolymer can be from several tens nanometers (nm) to several micrometers (占 퐉).

The amphiphilic block copolymer is referred to as an amphiphilic block copolymer. The amphiphilic block copolymer forms a membrane in water or oil phase by a self-assembly method by a hydrophobic effect , A polyomer formed from a diblock copolymer is formed with a polymeric material that exhibits unique properties depending on the properties of the block used. Such an amphiphilic diblock copolymer exhibits a structure similar to that of a typical low-molecular amphipatic compound having a hydrophobic tail and a hydrophilic head, and this structure induces a micelle structure through self-assembly process.

On the other hand, Poloxamer is a polyoxyethylene-polyoxypropylene triblock copolymer (poly (oxyethylene) -poly (oxypropylene) -poly (oxyethylene) triblock copolymer) having excellent surfactant property due to amphiphilic structure, And to improve the solubility of an oil-soluble substance in water, or to improve the miscibility of two or more substances having different hydrophobicity.

There are various kinds of poloxamers according to the molecular weight and content of polyoxypropylene, and they are widely used in various industries such as solubilizing agent, emulsifying agent and humectant. In addition, the range of applications such as continuous formulations, ophthalmic solutions, injections, and anticancer drugs for sustained release of the drug at the burn site is becoming widespread.

BACKGROUND ART [0002] The background art relating to the present invention is disclosed in Korean Patent Publication No. 1399341 (entitled "Amphiphilic triblock copolymer for accelerating skin absorption, method for producing the same, and cosmetic composition containing the same)" .

It is an object of the present invention to provide a micelle composition for cosmetics having an excellent skin softening effect.

Another object of the present invention is to provide a micelle composition for cosmetics which is excellent in transdermal absorption effect and formulation stability.

It is still another object of the present invention to provide a micelle composition for cosmetics which is excellent in skin barrier strengthening effect and antioxidation effect.

It is still another object of the present invention to provide a micelle composition for cosmetics that is excellent in feelability such as spreadability and spreadability.

One aspect of the present invention relates to a micelle composition for cosmetics. In one embodiment, the micelle composition for cosmetics comprises micelles dispersed in a stabilizing portion, and the micelle comprises a capsule and a core carried in the capsule, wherein the core is composed of a fatty acid, an aliphatic alcohol, an oil mixture, Wherein the capsule comprises a phospholipid and a second surfactant, wherein the stabilizing portion comprises water and a poloxamer, wherein the oil mixture is selected from the group consisting of a hydrocarbon-based oil, an ester-based oil, a silicone- Wherein the natural oil is selected from the group consisting of artemisia one of the annua) oil, papaya seed oil (papaya seed oil), pumpkin seeds five days (pumpkin seed oil), pomegranate seed oil (pomegranate seed oil), tomato seed oil (tomato seed oil), and curry leaf oil (curry leaf oil) Or more.

In one embodiment, the first surfactant and the second surfactant may each include at least one of an inulin, an amino acid, a glyceryl, and a polyethylene glycol surfactant.

In one embodiment, the first surfactant comprises a glyceryl surfactant, and the second surfactant comprises an amino acid surfactant and a polyethylene glycol surfactant in a weight ratio of 1: 0.1 to 1: 5.

In one embodiment, the average size of the micelles may be between 0.1 μm and 300 μm.

In one embodiment, the natural oil is selected from the group consisting of 1: 0.1 to 5: 0.1 to 5: 0.1 to 5: 0.1 to 5: 0.1, such as dogwood wormwood oil, papaya seed oil, pumpkin seed oil, pome seed oil, tomato seed oil, To 5 weight ratio.

In one embodiment, the oil mixture may include hydrocarbon-based oils, ester-based oils, silicone-based oils, and natural oils in a weight ratio of 1: 0.1 to 5: 0.1 to 5: 0.1 to 5.

In one embodiment, the core may be supported at a weight ratio of 1: 0.1 to 1:20 to the capsule.

In one embodiment, the natural oil is selected from the group consisting of marula oil, Gac fruit oil, baobab oil, cherry seed oil, ginseng seed oil, And may further comprise at least one of Moringa Oil, meadowfoam seed oil, annatto oil, emu oil and african walnut oil .

When the micellar composition of the present invention is applied, the poorly soluble active ingredient can be effectively solubilized by being immersed in micelles. It is excellent in transdermal absorption and formulation stability, excellent in feelability such as spreadability and spreadability when applied to skin, Skin barrier strengthening effect and skin softening effect are excellent.

FIG. 1 (a) shows a micelle composition according to an embodiment of the present invention, and FIG. 1 (b) shows a micelle composition according to a comparative example according to the present invention.
2 is an optical microscope photograph of a micelle according to an embodiment of the present invention.
FIG. 3 is a graph showing radical generation inhibition of a micelle composition according to an embodiment of the present invention. FIG.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to be exemplary, self-explanatory, allowing for equivalent explanations of the present invention.

For cosmetics Micelle  Composition

One aspect of the present invention relates to a micelle composition for cosmetics. In one embodiment, the micelle composition for cosmetics comprises micelles dispersed in a stabilizing portion, and the micelle comprises a capsule and a core carried in the capsule, wherein the core is composed of a fatty acid, an aliphatic alcohol, an oil mixture, Wherein the encapsulant comprises a phospholipid and a second surfactant, wherein the stabilizing moiety comprises a polyol, water and a poloxamer, wherein the oil mixture is selected from the group consisting of a hydrocarbon-based oil, an ester-based oil, a silicone- Wherein the natural oil is selected from the group consisting of artemisia annua oil, papaya seed oil, pumpkin seed oil, pomegranate seed oil, tomato seed oil, oil, and curry leaf oil.

Micelle

In the present invention, a micelle includes a capsule and a core carried inside the capsule. The capsule has a thermodynamically stable and uniform structure formed by a low molecular weight amphipathic compound material having both a hydrophilic group and a hydrophobic group, and the capsule encapsulates and stabilizes an unstable core component, have.

In one embodiment, the micelle may be spherical, cylindrical, or polyhedral.

In one embodiment, the average size of the micelles may be between 0.1 μm and 300 μm. In the present specification, the " size " is defined as the " maximum length " of the micelle. Within the above range, skin permeability, formulation stability, and feeling of use can be excellent.

core

The core comprises a fatty acid, an aliphatic alcohol, an oil mixture and a first surfactant.

fatty acid

The above-mentioned fatty acids are included for the purpose of securing the formulation stability by stabilizing the internal components of the core and improving usability during skin application. In one embodiment, the fatty acid may include one or more of stearic acid, isostearic acid, and oleic acid. For example, stearic acid.

In one embodiment, the fatty acid may be included in an amount of 0.1 to 5% by weight based on the total weight of the micelle composition. When contained in the above range, the feeling of use and the stability of the formulation can be excellent. For example, 0.5 to 1.5% by weight.

Aliphatic alcohol

In the present invention, the aliphatic alcohol is included for the purpose of improving the mixing property of the core component, the viscosity control, and the interface stability of the capsule and the core. In one embodiment, the aliphatic alcohol may include one or more of stearyl alcohol, cetyl alcohol, and behenyl alcohol.

In one embodiment, the aliphatic alcohol may be included in an amount of 0.1 to 5 wt% based on the total weight of the micelle composition. When the content is within the above range, the capsule and core interface stability may be excellent. For example, 0.1 to 2% by weight.

Oil mixture

The oil mixture is included for the purpose of improving the skin antioxidant ability and enhancing the skin barrier layer in addition to excellent feeling of use and skin flexibility when applying the skin of the present invention. In the present invention, the oil mixture includes a hydrocarbon-based oil, an ester-based oil, a silicone-based oil, and a natural oil.

The hydrocarbon-based oil is also referred to as a mineral oil and is included for the purpose of ensuring a soft feeling and a stability of formulation when applied to the skin. In one embodiment, the hydrocarbon-based oil may include a paraffinic hydrocarbon oil, an olefinic hydrocarbon oil, an aliphatic, alicyclic, and aromatic hydrocarbon-based oil. N-hexane, n-heptadecane, n-heptadecane, n-hexadecane, n-heptadecane, , n-octadecane, vaseline, paraffin, ceresin and squalane, and the like. These may be used alone or in combination of two or more.

In one embodiment, the hydrocarbon-based oil may be contained in an amount of 3 to 25% by weight based on the total weight of the micelle composition. When the content is in the above range, the stability and feeling of use of the core may be excellent. For example, 8 to 15% by weight.

The ester-based oil is included for the purpose of ensuring feeling of use and stability of formulation. In one embodiment, the ester oil is selected from the group consisting of C12-C15 alkyl benzoate, C12-C15 alkyl ethyl hexanoate, octyldodecyl myristate, tricaprylyl, octyldodecyl stearoyl stearate, caprylic / Triglyceride, isotridecylisononanoate and polyglyceryl-2 triisostearate, and the like. These may be used alone or in combination of two or more.

In one embodiment, the ester-based oil may be contained in an amount of 3 to 25% by weight based on the total weight of the micelle composition. When the content is within the above range, the stability and feeling of use of the core may be excellent. For example, 8 to 20% by weight.

The silicone-based oil is included for the purpose of securing viscosity control, feeling on use and stability of formulation of the core part. In one embodiment, the silicone oil is selected from the group consisting of hydrogenated dimethicone, amodimethicone, bisphenyl hexamethicone, dimethicone, hexadecylmethicone, methicone, phenyl trimethicone, simethicone, dimethylhydrogensiloxane, cyclopenta Siloxane, stearoxytrimethylsiloxane, vinyl dimethicone, and the like. These may be used alone or in combination of two or more.

In one embodiment, the silicone oil may be included in an amount of 0.1 to 15% by weight based on the total weight of the micelle composition. When the content is within the above range, the stability and feeling of use of the core may be excellent. For example, 3 to 12% by weight.

Natural oil

The natural oils include a skin softening effect, a skin barrier improving effect and an antioxidant effect. In one embodiment of the invention, the natural oils are selected from the group consisting of artemisia annua oil, papaya seed oil, pomegranate seed oil, tomato seed oil, and curry leaf oil.

The above-mentioned dog wormwood oil was classified into Artemisia It is an oil extracted from one or more parts of leaves, stems and roots of annua .

The papaya seed oil is an oil extracted by pressing seeds of papaya ( Carica papaya ).

The pomegranate seed oil is an oil extracted by pressing a seed of pomegranate ( Punica granatum ).

The tomato seed oil is a tomato ( Lycopersicon esculentum ) Oil extracted by squeezing seeds.

The Curry Leaf Curry oil tree (Murraya koenigii ) leaves.

In one embodiment, the natural oil may be included in an amount of 0.1 to 15% by weight based on the total weight of the micelle composition. Within the above range, skin antioxidation, skin softening, skin barrier improvement, skin softening effect and formulation stability can be excellent. For example, 3 to 12% by weight.

In one embodiment, the natural oil is selected from the group consisting of 1: 0.1-5: 0.1-5: 0.1-5: 0.1-5: 1, 0.1 to 5 weight ratio. When the content is in the above range, the natural oil component has excellent synergistic effect of antioxidant ability, skin moisturizing and softening, and can be excellent in feeling and stability of formulation. For example, from 1: 0.5 to 3: 0.5 to 2: 0.5 to 2: 0.5 to 2: 0.5 to 2. Other examples may be included in a weight ratio of 1: 0.8 to 2: 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2.

In another embodiment of the present invention, the natural oils are selected from the group consisting of marula oil, pumpkin seed oil, Gac fruit oil, baobab oil, cherry seed oil Ginseng seed oil, Moringa oil, meadowfoam seed oil, annatto oil, emu oil and african walnut oil, oil) may be further included.

The marula oil is marula, Scelerocarya birrea ) It is the oil extracted by squeezing the seed of the tree fruit.

The pumpkin seed oil is a pumpkin ( Cucurbita spp . ) Is the oil extracted by squeezing the seeds.

The above-mentioned Gac fruit oil is an oil extracted from a tropical fruit (M. cochinchinensis) grown in Southeast Asia and the like.

The baobab oil is an oil extracted from the seeds of a baobab tree ( Adansonia ).

The cherry seed oil is cherry ( Prunus pauciflora Bunge or Prunus avium Schneider ) seeds.

The carrot seed oil is extracted as an oil by pressing the seeds of ginseng (Panax ginseng CA .Meyer), it may contain antioxidants, such as saponin.

The Moringa five days (Moringa Oil) is Moringa (Moringa oleifera Lam. ) It is oil extracted by squeezing the seeds of nuts.

The meadowfoam seed oil is available from the Meadows Foam ( Limnanthes, Alba ) is an oil extracted by squeezing the seeds of nuts. The Meadow Foam seed oil is added to prevent skin aging and delayed action, skin soothing action, and moisturizing action. Meadofoam seed oil contains natural tocopherol, which has antioxidative effects that prevent skin aging and delayed action, has excellent skin softening effect, gives a smooth texture to dry skin, forms a film preventing moisture loss To keep moisturizing.

The annatto oil is also called as safflower seed oil, and is an oil extracted from the seeds of safflower ( Carthamus tinctorius ).

The emu oil is also referred to as caraya oil and is an oil extracted from the fat of emu.

The African walnut oil is an oil extracted by sowing seeds of African walnut ( plukenetia volubilis ).

In one embodiment, the natural oil is selected from the group consisting of 1: 0.1-5: 0.1-5: 0.1-5: 0.1-0.5: 0.1-5: 0.1-5: 5: 0.1 to 5: 0.1 to 5 by weight. When the content is in the above range, the natural oil component has excellent synergistic effect of antioxidant ability, skin moisturizing and softening, and can be excellent in feeling and stability of formulation. For example, from 1: 0.5 to 3: 0.5 to 2: 0.5 to 2: 0.5 to 2: 0.5 to 2: 0.5 to 2. Other examples may be included in a weight ratio of 1: 0.8 to 2: 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2.

In one embodiment, the oil mixture may contain the hydrocarbon-based oil, the ester-based oil, the silicone-based oil, and the natural oil in a weight ratio of 1: 0.1-5: 0.1-5: 0.1-5. When the content ratio is included, the synergistic effect of antioxidation, skin barrier strengthening and skin softening of the core component is excellent, and the use feeling and the formulation stability can be excellent at the same time. For example, in a weight ratio of 1: 0.5 to 3: 0.5 to 1.5: 0.5 to 1.5. Other examples may be included in a weight ratio of 1: 1 to 2: 0.3 to 0.8: 0.3 to 0.8.

SHARE  butter

In another embodiment of the invention the core is shea butter (Butyrospermum Parkii , shea butter). The shea butter is a fat extracted from the fruit of the shea tree inhabited in Africa and improves the stability of the formulation of the core and imparts excellent skin elasticity and moisturizing effect when applied to the skin.

In one embodiment, the shear butter may be included in an amount of 0.1 to 5 wt% based on the total weight of the micelle composition. When it is included in the above range, stability of formulation and elasticity and moisturizing effect when applied to skin can be excellent. For example, 0.1 to 2% by weight.

The first surfactant

The first surfactant is included for the purpose of securing the formulation stability of the core component. In one embodiment, the first surfactant may include at least one of an inulin, an amino acid, a glyceryl, and a polyethylene glycol surfactant.

The inulin surfactant may include at least one of inulin, stearoyl inulin, inulin lauryl carbamate, and palmitoyl inulin.

Examples of the amino acid surfactant include sodium diauraramidoglutamide lysine, sodium cocoyl glutamate, sodium cocoyl apple amino acid, sodium lauroyl glutamate, sodium myristoyl glutamate, But are not limited to, glutamate, sodium palmitoyl glutamate, sodium stearoyl glutamate, disodium cocoyl glutamate, disodium stearoyl glutamate, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium cocoyl alaninate, TEA cocoyl glutamate, TEA lauroyl allaninate, sodium cocoyl glycinate, potassium cocoyl glycinate sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium Oleoyl sarcosinate, arginine hexylate When sarcoidosis days with phosphate and ammonium laurate may include one or more of the carbonate.

Examples of the glyceryl-based surfactant include polyglyceryl caprylate, polyglyceryl caprate, polyglyceryl laurate, polyglyceryl myristate, polyglyceryl stearate, polyglyceryl oleate, polyglyceryl isostearate , Polyglyceryl diisostearate, polyglyceryl dilaurate, polyglyceryl diolate, and polyglyceryl di-myristate.

Examples of the polyethylene glycol surfactant include polyethylene glycol isostearate, polyethylene glycol diisostearate, polyethylene glycol glyceryl isostearate, polyethylene glycol glyceryl triisostearate, polyethylene glycol laurate, polyoxyethylene sorbitan tetraol 0.0 > polyoxyethylene < / RTI > triolate, polysorbate 85, polysorbate 60, and polysorbate 80.

In one embodiment, the first surfactant may comprise a glyceryl surfactant. The glyceryl-based surfactant is a form in which a fatty acid is bound to polyglyceryl, and a lamellar liquid crystal is formed on the skin to improve the skin barrier improving effect. The adsorbability to the solid surface is high, so that the stability between the core and the capsule can be secured. Also, it is suitable for use as a surfactant in the core portion because stability at low pH and high temperature and low temperature is ensured. When the glyceryl-based surfactant is included, the interfacial stability between the capsule and the core is excellent, so that the interfacial stability can be excellent even under external conditions such as high temperature.

In one embodiment, the first surfactant may be included in an amount of 0.1 to 8 wt% based on the total weight of the micelle composition. When the content is in the above range, physical strength of the core and capsule interface is excellent, and the stability of the formulation can be excellent. For example, 0.1 to 5% by weight.

capsule

The capsule comprises a phospholipid and a second surfactant.

Phospholipids

The phospholipid is included for the purpose of forming a micelle structure and stably supporting a core component. In one embodiment, the phospholipid can include one or more of lecithin, hydrogenated lecithin, lysolecithin, and hydroxylated lecithin. For example, lecithin. In one embodiment, the lecithin may include at least one of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidylserine, and phosphatidyl glycerin. When the phospholipid of the above kind is included, the elasticity is increased, the component to be supported on the inside is stably maintained, and the deformation force is excellent, so that the penetration can be effectively carried out between the keratin and the transdermal absorption efficiency can be excellent.

In one embodiment, the phospholipid may be included in an amount of 0.5 to 8 wt% based on the total weight of the micelle composition. When the content is in the above range, the physical strength of the core and capsule interface is excellent, and the elasticity and formulation stability of the capsule can be excellent. For example, 1 to 5% by weight.

The second surfactant

The second surfactant is included for the purpose of securing interfacial stability of the capsule and elasticity of the capsule. In one embodiment, the second surfactant may include at least one of an inulin, an amino acid, a glyceryl, and a polyethylene glycol surfactant. As the surfactant, the same surfactants as described above can be used.

The amino acid surfactant is a gemini anionic surfactant having two hydrophobic moieties and two hydrophobic moieties in one molecule and has low skin irritation and low micelle formation concentration so that micellar capsules are formed even in a small amount can do. In addition, a double membrane is formed at the time of capsule formation to form a gel network of a liquid crystal to help improve a skin barrier, and a unique feeling can be provided, thereby doubling an aesthetic effect. Therefore, the interfacial stability between the capsule and the core is ensured when the surfactant is incorporated through the gel network, so that the interface stability can be excellent even under external conditions such as high temperature.

The polyethylene glycol surfactant is a nonionic surfactant having ethylene glycol added to higher alcohols. It has excellent emulsifying power and increases the viscosity of the emulsifying system. Therefore, it has a unique feeling of use when applied to emulsified products, When applied to the skin, it can have a skin softening effect.

In one embodiment, the second surfactant may include an amino acid surfactant and a polyethylene glycol surfactant. When the surfactant is included, the interfacial stability between the capsule and the core is excellent, and the interfacial stability can be excellent even under external conditions such as high temperature.

In one embodiment, the second surfactant may be included in an amount of 0.1 to 8% by weight based on the total weight of the micelle composition. When the content is in the above range, the physical strength of the core and capsule interface is excellent, and the elasticity and formulation stability of the capsule can be excellent. For example, 0.1 to 6% by weight.

In one embodiment, the second surfactant may include the amino acid surfactant and the polyethylene glycol surfactant in a weight ratio of 1: 0.1 to 1: 5. The weight ratio thereof is excellent in feeling of use and excellent in physical strength of the capsule interface, so that the capsule can be excellent in elasticity and formulation stability. For example, sodium diaramidoglutaramidolysin and polysorbate 60 at a weight ratio of 1: 0.1 to 1: 5.

In one embodiment, the core may be supported at a weight ratio of 1: 0.1 to 1:20 (capsule: core) to the capsule. Within this range, the formulation stability and feeling of use can be excellent. For example, in a weight ratio of 1: 3 to 1:10.

Stabilizing portion

The stabilizing part comprises a polyol, water and a poloxamer.

water

The water is included for the purpose of moldability and viscosity control. In one embodiment, the water may be included in an amount of 25 to 50 wt% based on the total weight of the micelle composition. Within the above range, the moldability and skin moisturizing property of the micelle composition can be excellent. For example, 15 to 35% by weight.

Pollock Sommer

The poloxamer (polyoxyethylene-polyoxypropylene triblock copolymer) can improve the solubility of the micelles of the present invention and improve the mixing and formulation stability For example. The poloxamer may be Poloxamer 407 or Poloxamer 188 or the like.

In one embodiment, the poloxamer may be included in an amount of 0.1 to 5 wt% based on the total weight of the micelle composition. In the above range, the solubility, mixing property and formulation stability of the micelle composition can be excellent. For example, 0.1 to 2% by weight.

Polyol

In one embodiment, the stabilizing moiety may further comprise a polyol for the purpose of improving formulation stability. The polyol may include at least one of 1,2-hexanediol, glycerin, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol and panthenol. In one embodiment, the polyol may include glycerin and 1,2-hexanediol. The above glycerin is called glycerol and is included for the purpose of improving formulation stability and skin moisturizing power of the present invention. For example, the polyol may include glycerin and 1,2-hexanediol in a weight ratio of 1: 0.05 to 1: 0.5. Within the above range, the stability of the stabilizing part and the skin moisturizing ability can be excellent.

In one embodiment, the polyol may be contained in an amount of 3 to 30% by weight based on the total weight of the micelle composition. Within the above range, the formulation stability and skin moisturizing property of the micelle can be excellent. For example, 9 to 23% by weight.

The micelle composition for cosmetics may be contained in an amount of 0.1 to 50% by weight based on the total weight of the cosmetic composition. When included in the above range, formulation stability, skin flexibility and skin moisturizing effect can be excellent. For example, 1 to 30% by weight.

The above-described micelle composition for cosmetics may further contain components contained in a conventional cosmetic composition in addition to the components described above. For example, it may further include one or more ingredients listed in the list of cosmetic ingredients registered in the Food and Drug Administration and ICID (International Cosmetic Ingredient Collection). In one embodiment, the micelle composition for cosmetics may further comprise a colorant, a flavoring agent, a pH adjusting agent, a sequestering agent, a preservative, and the like.

The above-described micelle composition for cosmetics may be formulated containing a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example as a solution, a gel, a solid, a paste anhydrous product, an emulsion obtained by dispersing an oil phase in water, a suspension, a microemulsion, a microcapsule, a microgranule or an ionic form (liposome) In the form of ionic fibrin dispersions, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. It can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions may be prepared according to conventional methods in the art.

For cosmetics Micelle  Method of manufacturing composition

Another aspect of the present invention relates to a method for preparing a micelle composition for cosmetics. In one embodiment, the method for preparing a micelle composition for cosmetics comprises: (a) heating a first mixture; (b) heating the second mixture; (c) a third mixture preparation step; (d) a cooling step; And (e) a pressing step. More specifically, the method for preparing a cosmetic micelle composition comprises the steps of: (a) heating a first mixture comprising a fatty acid, an aliphatic alcohol, an oil mixture, and a first surfactant to 55 ° C to 75 ° C; (b) heating the second mixture comprising the phospholipid and the second surfactant to 55 ° C to 75 ° C; (c) mixing the heated first mixture and the second mixture to prepare a third mixture having a primary micelle formed therein; (d) cooling the third mixture to 15 < 0 > C to 25 < 0 >C; And (e) adding polyol, water and poloxamer to the cooled third mixture, and pressurizing the mixture at 400 to 1500 bar to form a second micelle.

(a) a first mixture heating step

This step is a step of heating the first mixture comprising the fatty acid, the aliphatic alcohol, the oil mixture and the first surfactant. In one embodiment, the first mixture is heated to 55 ° C to 75 ° C. The mixture may be easily mixed when heated to the above temperature range. The fatty acid, aliphatic alcohol, oil mixture and first surfactant may be the same as the above-mentioned components.

(b) a second mixture heating step

This step is a step of heating the second mixture comprising the phospholipid and the second surfactant to 55 ° C to 75 ° C. In one embodiment, the second mixture is heated to 55 ° C to 75 ° C. The mixture may be easily mixed when heated to the above temperature range. The phospholipids and the second surfactant may be the same as the above-mentioned components.

(c) the third mixture preparation step

The step of mixing the heated first mixture and the second mixture is a step of preparing a third mixture in which the first micelle is formed.

(d) cooling step

The step is a step of cooling the third mixture. In one embodiment, the cooling cools the third mixture to 15 < 0 > C to 25 < 0 > C.

(e) Pressurization step

In this step, polyol, water and poloxamer are added to the cooled third mixture, and the mixture is pressurized to 400 to 1,500 bar to form a secondary micelle. Under the above conditions, a micelle having a stabilized structure upon pressurization can be formed, so that the stability of the formulation can be facilitated. The same polyol, water, and poloxamer as the above-described components may be used.

Hereinafter, the structure and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. It is to be understood, however, that the same is by way of illustration and example only and is not to be construed in a limiting sense.

The contents not described here are sufficiently technically inferior to those skilled in the art, and a description thereof will be omitted.

Example  And Comparative Example

Using the ingredients and the contents shown in Table 1 below, a micelle composition for cosmetics was prepared. Of the components listed in Table 1 below, the natural oil and the second surfactant used the following components.

(a1) First surfactant: glyceryl monostearate was used. (a2) First Surfactant: Polyoxyethylene alkyl ether compound was used.

(b1) Natural oil: Natural oil containing 1: 2: 1: 1: 1: 1: 1 by weight of oil of coconut oil, papaya seed oil, pumpkin seed oil, pome seed oil, tomato seed oil and curry leaf oil was used. (b2) Natural oil: Dogwood mugwort oil was used. (b3) Natural oil: Papaya seed oil was used. (b4) natural oils containing 1: 2: 1: 1: 1: 1: 1: 1 ratio of natural oil: cocoon oil, papaya seed oil, pumpkin seed oil, pome seed oil, tomato seed oil, curry leaf oil and baobab oil Oil was used.

(c1) Second Surfactant: A surfactant comprising 0.2% by weight of sodium diaramidoglutamate lysine and 5% by weight of polysorbate 60 was used. (c2) Second Surfactant: Polyoxyethylene alkyl ether compound was used.

Example  One

Using the ingredients and the contents shown in Table 1 below, a micelle composition for cosmetics was prepared. (Stearic acid), aliphatic alcohol (stearyl alcohol), hydrocarbon oil (mineral oil), ester oil (caprylic / capric triglyceride), silicone oil (dimer Chicone) and the natural oil and the first surfactant were heated to 65 占 폚. The second mixture comprising the phospholipid (lecithin) and the second surfactant was then heated to 65 占 폚.

Then, the heated first mixture and the second mixture were mixed to prepare a third mixture in which the first micelle was formed, and the third mixture was cooled to room temperature (25 캜). Polyol (1,2-hexanediol and glycerin), water and poloxamer were added to the cooled third mixture, and the mixture was pressurized at 1200 bar to form secondary micelles, thereby preparing a micelle composition having an average size of 10 μm.

Example  2 to 4

The myc shell composition was prepared in the same manner as in Example 1, except that the components and contents in the following Table 1 were used.

Comparative Example  1-4

The myc shell composition was prepared in the same manner as in Example 1, except that the components and contents in the following Table 1 were used.

Comparative Example  5

The same contents and components as in Example 1 of Table 1 were applied and mixed at room temperature using a stirrer to prepare a composition without micelle formation.

Test Example  One. Formulation stability  evaluation

To measure the stability of the micelle compositions of Examples 1 to 4 and Comparative Examples 1 to 5 with respect to the degree of discoloration, a thermostat kept constant at 45 ° C, 25 ° C, and 4 ° C, 4 and Comparative Examples 1 to 5 were put in containers for 5 weeks and stored for 4 weeks, and the degree of separation and discoloration was comparatively measured. The results are shown in Table 2 below. The degree of separation and discoloration of the product was classified into the following six grades and evaluated.

* Separation and discoloration evaluation criteria

4: Severely separated (discolored), 5: Severely separated (discolored), 2: slightly separated (discolored), 3: slightly separated (discolored)

FIG. 1 (a) shows the characteristics of the micelle composition of Example 1 of the present invention, and FIG. 1 (b) shows the characteristics of the micelle composition of Comparative Example 1 of the present invention. Referring to FIG. 1, it can be seen that, in the case of Example 1, the capsules containing the core component including the oil are solubilized and mixed in a stable form. However, in the case of Comparative Example 1, it was found to be a grayish white color, and the overall property was not smooth.

With reference to Table 2, the cosmetic compositions of Examples 1 to 4 hardly undergo discoloration and separation phenomena, but Comparative Examples 1 to 3, which contain the components of the present invention or to which different components are applied, It was found that the separation and discoloration occurred significantly in the case of Comparative Example 5 in which no organic solvent was formed.

Test Example  2. Evaluation of skin improvement effect

When the above-mentioned Examples 1 to 4 and Comparative Examples 1 to 5 were used, overall preferences such as skin moisturizing effect, skin softening effect, and flushing feeling were evaluated. Specifically, 40 women aged 15 to 30 years were allowed to use each of Examples 1 to 4 and Comparative Examples 1 to 5 by 5 persons for 2 weeks (twice a day (morning and evening)), (1: very bad → 10: very good), the skin's moisturizing, skin softening effect and feelings were evaluated for overall preference, followed by Duncan's multiple range test. As a result, the results shown in Table 3 were obtained.

Referring to Table 3, it can be seen that Examples 1 to 4 of the present invention are superior to those of Comparative Examples 1 to 5 in terms of skin moisturizing, skin softening effect and overall preference. In particular, In the case of Example 4, it was found that the overall preference such as skin moisturizing effect, skin softening effect, and skin rusting property was remarkably lowered as compared with Examples 1 to 4 above.

2 is an optical microscope photograph showing the micelle of Example 1 of the present invention. Referring to FIG. 2, it was found that spherical capsules were formed, and skin barrier improvement and moisturizing effect were excellent.

Test Example  3. Antioxidant effect measurement

Free radicals are very reactive species with unpaired electron pairs. ROS produced in vivo contains free radical species such as superoxide anion radical (O- ² ) and hydroxyl radical (OH). These radicals react with the various constituents of the skin with high reactivity, thereby damaging the various tissues present in the skin. Thus, free radicals can be a major cause of skin damage and aging. The reducing power of antioxidants that reduce such free radicals can be found by using 1,1-diphenyl-2-picryl hydrazine (DPPH). Since DPPH is a relatively stable free radical, it is an oxidizing agent widely used in experiments.

It measures the extent to which purple is removed as the sample clears the radicals. First, 0.15 ml of a solution prepared by dissolving DPPH in methanol at a concentration of 1x10 ^-4 M was put into a test tube, and 0.15 ml of each sample was added to each of the concentrations of Examples 1 to 4 and Comparative Examples 1 to 3 at 20 The absorbance was measured at 565 nm after the minute reaction. The free radical scavenging effect of each of the samples of the examples and comparative examples was determined by IC50 by calculating the concentration at which 50% of radicals were eliminated by using the following equation (1). At this time, ascorbic acid was used as a positive control group and the reaction absorbance of the solution not treated with the sample was used as a negative control group. The free radical scavenging effect of each sample was determined by calculating the concentration at which 50% of the radicals were eliminated by using Equation 1 and expressed as IC50, and the results are shown in Table 4 and FIG.

[Formula 1]

Free radical scavenging ratio (%) = [(absorbance of control group - absorbance of each sample) / absorbance of control group] × 100

division IC50 (mg / mL) Example 1 1.06 Example 2 7.47 Example 3 2.89 Example 4 0.95 Comparative Example 1 3.54 Comparative Example 2 10.54 Comparative Example 3 10.78 Positive control group 0.7

Referring to Table 4, the IC50 values of Examples 1 to 4 of the present invention were superior to those of the control group.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (8)

And a micelle dispersed in the stabilizing portion,
Wherein the micelle comprises a capsule and a core carried inside the capsule,
Wherein the core comprises a fatty acid, an aliphatic alcohol, an oil mixture and a first surfactant,
Wherein the capsule comprises a phospholipid and a second surfactant,
Wherein the stabilizing portion comprises a polyol, water and a poloxamer,
Wherein the oil mixture comprises a hydrocarbon-based oil, an ester-based oil, a silicone-based oil, and a natural oil,
The natural oils are artemisia one of the annua) oil, papaya seed oil (papaya seed oil), pumpkin seeds five days (pumpkin seed oil), pomegranate seed oil (pomegranate seed oil), tomato seed oil (tomato seed oil), and curry leaf oil (curry leaf oil) Or more of the total weight of the cosmetic composition.
The micelle composition for cosmetics according to claim 1, wherein the first surfactant and the second surfactant each include at least one of an inulin, an amino acid, a glyceryl, and a polyethylene glycol surfactant.
3. The composition of claim 2, wherein the first surfactant comprises a glyceryl surfactant,
Wherein the second surfactant comprises an amino acid surfactant and a polyethylene glycol surfactant in a weight ratio of 1: 0.1 to 1: 5.
2. The micelle composition for cosmetics according to claim 1, wherein the average size of the micelles is 0.1 mu m to 300 mu m.
The natural oil according to claim 1, wherein the natural oil is selected from the group consisting of 1: 0.1-5: 0.1-5: 0.1-5: 0.1-0.5: 5: 0.1 to 5 weight ratio.
The micelle composition for cosmetics according to claim 1, wherein the oil mixture comprises hydrocarbon-based oil, ester-based oil, silicone-based oil and natural oil at a weight ratio of 1: 0.1-5: 0.1-5: 0.1-5.
The micelle composition for cosmetics according to claim 1, wherein the core is supported at a weight ratio of 1: 0.1 to 20 to the capsule.
The method of claim 1, wherein the natural oil is selected from the group consisting of marula oil, Gac fruit oil, baobab oil, cherry seed oil, ginseng seed oil ), Moringa oil, meadowfoam seed oil, annatto oil, emu oil, and african walnut oil. ≪ / RTI >

Images