KR20100106975A - Bactericidal cleanser composition - Google Patents

Abstract

(A) a cationic fungicide, (B-1) nonionic surfactant selected from polyoxyethylene hardened castor oil of HLB9-16, monostearic acid polyoxyethyleneglycerin and monostearic acid polyethyleneglycol, (C) amino acid or its salt, And (D) 16 to 40% by mass of alcohols having 1 to 3 carbon atoms, which are filled in a former container and discharged in the form of bubbles, wherein the disinfecting detergent composition of the non-washable type is used.

Description

Bactericidal Detergent Composition {BACTERICIDAL CLEANSER COMPOSITION}

The present invention relates to a sterilizing detergent composition of a non-washable type used in foam.

In conventional disinfectant detergents, washing is the mainstream, so it is difficult to use it in a place without water such as in the outside or living room, and the dosage form is gel-like (see Patent Document 1: Japanese Patent No. 3499882) It was a spray form. However, the gel disinfectant has a problem in feeling of use such as stickiness after use by the thickener added, and the spray form has a problem in usability such as scattering on the bottom or the like. On the other hand, there has been proposed a technique of using a sterilizing detergent as a foam (Patent Document 2: Japanese Patent Application Laid-Open No. 10-330799, Patent Document 3: Japanese Patent Application Laid-Open No. 2001-139993, Patent Document 4: Japanese Patent Application Laid-Open No. 62-135410). ), There is a problem that it dries late, bubbles remain even after opening, or foam retention is poor. After the hand is opened, a non-washable type of antiseptic detergent composition for use in a foam is desired that foam is extinguished at a suitable time, is free of debris, and is easy to dry.

Patent Document 1: Japanese Patent No. 3499882 Patent Document 2: Japanese Patent Application Laid-Open No. 10-330799 Patent Document 3: Japanese Patent Application Laid-Open No. 2001-139993 Patent Document 4: Japanese Patent Application Laid-Open No. 62-135410

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and when it is taken by hand, it has foam retention and does not fall off from the hand easily. After it is opened, the foam is turned off at a suitable time, there is no bubble residue, and it is easy to dry. It is an object of the present invention to provide a sterile detergent composition of the type that does not.

MEANS TO SOLVE THE PROBLEM As a result of earnestly examining in order to achieve the said objective, even if it mix | blends a C1-C3 alcohol with the combination of a specific nonionic surfactant, an amino acid, or its salt, in the bactericidal detergent composition containing a cationic fungicide, In the case of hand-washing, it has a foam retaining property and does not easily fall off from the hand, while after hand-opening, the foam is turned off at a suitable time, and there is no bubble residue and it is easy to dry. It is found that can be obtained, and came to achieve the present invention. Poor dropping of the foam when taken by hand is correlated with the shape retention of the foam. The better the shape retention, the better the bubble does not fall when taken by hand, and the usability is good. On the other hand, since the foam taken by hand disappears at a suitable time and becomes a fluid liquid, it is easy to rub on a finger and the usability becomes good. Thus, it is difficult to anticipate from the said prior art, and the inventors newly discovered that the special effect was exhibited by setting it as the structure of this invention.

Accordingly, the present invention provides the following sterile detergent composition.

[One]. (A) a cationic fungicide, (B-1) nonionic surfactant selected from polyoxyethylene hardened castor oil of HLB9-16, monostearic acid polyoxyethyleneglycerin and monostearic acid polyethyleneglycol, (C) amino acid or its salt, And (D) 16 to 40% by mass of alcohols having 1 to 3 carbon atoms, which are filled in a former container and discharged in the form of bubbles, wherein the disinfecting detergent composition of the non-washable type is used.

[2]. (A) Cationic fungicide, (B-2) the following general formula (1) of HLB10-14

(In formula, m is 6-10, n represents the integer of 10-25.)

Nonionic surfactants selected from polyoxyethylene branched alkyl ethers and polyoxyethylene cholesteryl ethers, (C) amino acids or salts thereof, and (D) 30 to 70 masses of alcohols having 1 to 3 carbon atoms. A sterilizing detergent composition of a non-washable type, comprising% and filled in a foamer container and discharged in a foam form.

[3]. The sterilizing detergent composition as described in [1] or [2] whose (A) component is benzalkonium chloride, benzetonium chloride, or cetylpyridinium chloride.

According to the present invention, it has a property of having foam retaining properties when it is taken by hand and does not easily fall off from the hand. On the other hand, after being applied to the hand, the foam is turned off at a suitable time, and it is used as a foam which is free of debris and easy to dry. A sterile detergent composition of the type which does not wash off can be provided.

Hereinafter, the present invention will be described in more detail.

The first bactericidal detergent composition of the present invention is a nonionic selected from (A) cationic fungicide, (B-1) polyoxyethylene cured castor oil of HLB9-16, monostearic acid polyoxyethyleneglycerin and monostearic acid polyethylene glycol It contains a surfactant, (C) an amino acid or its salt, and (D) 16-40 mass% of C1-C3 alcohols, is made to fill a former container, and is discharged in foam form, and is not wash | cleaned. A type of bactericidal detergent composition, wherein the second bactericidal detergent composition is (A) a cationic bactericide, (B-2) polyoxyethylene branched alkyl ether and polyoxyethylene chole represented by the general formula (1) of HLB10 to 14 A nonionic surfactant selected from styryl ether, (C) amino acid or salt thereof, and (D) 30 to 70% by mass of alcohol having 1 to 3 carbon atoms are charged, It made and the sterilization of the detergent composition characterized in that the discharge of foam shape, that is to wash type.

(A) cationic fungicide

As a cationic fungicide, what is represented by following General formula (2) or (3) is mentioned, One type can be used individually or 2 or more types can be used together.

[Wherein, R ¹ and R ² each represent an alkyl group having 8 to 18 carbon atoms, an alkenyl group or a hydrocarbon group having an ether bond, and X and Y each represent a halogen atom, an amino acid or a fatty acid.]

Examples of the compound represented by the general formula (2) include benzalkonium chloride and benzethonium chloride, and examples of the compound represented by the general formula (3) include cetylpyridinium chloride and the like. Especially, benzalkonium chloride and cetylpyridinium chloride are preferable at the point of the shape retention of foam.

As for the compounding quantity ((total amount when using 2 or more types together) of (A) component, 0.01-1 mass% is preferable in a sterilizing detergent composition, More preferably, it is 0.01-0.5 mass%. If it is less than 0.01 mass%, there exists a possibility that sterilization performance may become inadequate, and even if it mix | blends more than 1 mass%, it may become excessive amount as sterilization performance, or there may be a bubble residue after hand rub.

(B-1) Nonionic surfactant selected from polyoxyethylene hardened castor oil, monostearic acid polyoxyethyleneglycerin and monostearic acid polyethyleneglycol of HLB9-16

As polyoxyethylene hydrogenated castor oil of HLB9-16 (Hereinafter, polyoxyethylene may abbreviate as POE.) For example, polyoxyethylene (20) hydrogenated castor oil (HLB9), polyoxyethylene (30 ) Cured Castor Oil (HLB11), Polyoxyethylene (40) Cured Castor Oil (HLB12), Polyoxyethylene (50) Cured Castor Oil (HLB13), Polyoxyethylene (60) Cured Castor Oil (HLB14), Polyoxyethylene (80) hydrogenated castor oil (HLB15) and polyoxyethylene (100) hydrogenated castor oil (HLB15).

As monostearic acid polyoxyethylene glycerin of HLB9-16, polyoxyethylene (5) glyceryl monostearate (henceforth represented by stearic acid PEG-5 glyceryl (HLB9)), stearic acid PEG-10 glyceryl (HLB11), Stearic acid PEG-15 glyceryl (HLB13), stearic acid PEG-20 glyceryl (HLB14), stearic acid PEG-30 glyceryl (HLB15), stearic acid PEG-40 glyceryl (HLB16), and the like.

As monostearic acid polyethyleneglycol of HLB9-16, polyoxyethylene (10) monostearate (it shows as stearic acid PEG-10 (HLB11) hereafter), stearic acid PEG-20 (HLB14), stearic acid PEG-30 (HLB15), Stearic acid PEG-40 (HLB16).

The said nonionic surfactant of HLB9-16 of this invention can be used individually by 1 type or in combination of 2 or more types. Especially, polyoxyethylene hardened castor oil of HLB12-15, polyoxyethylene glycerin monostearate, polyethyleneglycol monostearate is preferable, For example, polyoxyethylene (40) hardened castor oil (HLB12), polyoxyethylene ( 50) Cured Castor Oil (HLB13), Polyoxyethylene (60) Cured Castor Oil (HLB14), Polyoxyethylene (80) Cured Castor Oil (HLB15), Polyoxyethylene (100) Cured Castor Oil (HLB15), Stearic Acid PEG -15 glyceryl (HLB13), stearic acid PEG-20 glyceryl (HLB14), stearic acid PEG-30 glyceryl (HLB15), stearic acid PEG-20 (HLB14), stearic acid PEG-30 (HLB15). In the nonionic surfactant of (B-1), below HLB9, foam retaining property worsens, and even if it exceeds HLB16, foam retaining property may worsen.

(B-2) Nonionic surfactant chosen from polyoxyethylene branched alkyl ether and polyoxyethylene cholesteryl ether represented by following General formula (1) of HLB10-14

(Wherein m represents 6 to 10 and n represents an integer of 10 to 25).

As polyoxyethylene branched alkyl ether represented by General formula (1), the following are mentioned, for example.

m = 6, n = 10: polyoxyethylene (10) isocetyl ether (HLB11)

m = 6, n = 15: polyoxyethylene (15) isocetyl ether (HLB13)

m = 6, n = 20: polyoxyethylene (20) isocetyl ether (HLB14)

m = 7, n = 10: polyoxyethylene (10) isostearyl ether (HLB11)

m = 7, n = 15: polyoxyethylene (15) isostearyl ether (HLB12)

m = 7, n = 20: polyoxyethylene (20) isostearyl ether (HLB13)

m = 7, n = 25: polyoxyethylene (25) isostearyl ether (HLB14)

m = 8, n = 10: polyoxyethylene (10) octyldodecyl ether (HLB10)

m = 8, n = 16: polyoxyethylene (16) octyldodecyl ether (HLB12)

m = 8, n = 20: polyoxyethylene (20) octyldodecyl ether (HLB13)

m = 8, n = 25: polyoxyethylene (25) octyldodecyl ether (HLB14)

m = 10, n = 15: Polyoxyethylene (15) decyl tetradecyl ether (HLB11)

m = 10, n = 20: polyoxyethylene (20) decyl tetradecyl ether (HLB12)

m = 10, n = 25: polyoxyethylene (25) decyl tetradecyl ether (HLB13)

Especially, HLB10-13 are preferable at the point of the shape retention of foam, Specifically, polyoxyethylene (10) octyl dodecyl ether (HLB10), polyoxyethylene (16) octyl dodecyl ether (HLB12), Polyoxyethylene (20) octyldodecyl ether (HLB13), polyoxyethylene (15) decyl tetradecyl ether (HLB11), polyoxyethylene (20) decyl tetradecyl ether (HLB12), polyoxyethylene (25) decyl tetra Decyl ether (HLB13). In the nonionic surfactant of (B-2), below HLB10, foam retaining property worsens, and even if it exceeds HLB14, foam retaining property may worsen.

As polyoxyethylene cholesteryl ether, as polyoxyethylene cholesteryl ether, polyoxyethylene (10) cholesteryl ether (HLB10), polyoxyethylene (15) cholesteryl ether (HLB11), polyoxyethylene ( 20) cholesteryl ether (HLB12), polyoxyethylene (24) cholesteryl ether (HLB13), polyoxyethylene (30) cholesteryl ether (HLB14), and the like, and polyoxyethylene (10). Cholesteryl ether (HLB10), polyoxyethylene (15) cholesteryl ether (HLB11), and polyoxyethylene (20) cholesteryl ether (HLB12) are particularly preferred. In addition, () shows the average added mole number of ethylene oxide.

In addition, an HLB value is a value which shows the balance of the strength of the hydrophilic group and hydrophobic group which comprise surfactant, and a calculation method is based on the formula of the following Kawagami.

HLB value = 7 + 11.7 log (M _W / M _O )

M _W : Molecular Weight of Surfactant Hydrophilic Part

M _O : Molecular weight of surfactant lipophilic part

As for the compounding quantity (total amount when using 2 or more types together) of (B-1) and (B-2) component, 0.01-1.0 mass% is preferable in a sterilizing detergent composition, and 0.1-0.5 mass% is the shape retention of foam. It is more preferable at the point that there is no bubble dreg after putting hands together. If it is less than 0.01 mass%, foam retention may become inadequate, and if it exceeds 1.0 mass%, stickiness may occur after use or foam residue after rubbing hands may remain.

(C) amino acids or salts thereof

Examples of the amino acids of the present invention include glycine, lysine, serine, proline, arginine, glutamic acid and the like, and amino acid derivatives of pyrrolidone carboxylic acid. These may be used alone or in combination of two or more thereof as appropriate. . As a salt, an alkali metal, alkaline earth metal, etc. are mentioned, for example. Examples thereof include sodium glutamate, sodium dl-pyrrolidone carboxylate, and the like. Among these, sodium dl-pyrrolidone carbonate, lysine, serine, and glycine are preferable, and sodium dl-pyrrolidone carboxylic acid is particularly preferable from the viewpoint of foam retention.

As for the compounding quantity ((total amount when using 2 or more types together) of (C) component, 0.01-5 mass% is preferable in sterilizing detergent composition, and 0.1-1 mass% is further more preferable. If the amount is less than 0.01% by mass, the foam taken by hand may be difficult to disappear at a suitable time, and there may be no bubble residue. If the amount exceeds 5% by mass, foam retention may be insufficient at the time of discharge.

(D) alcohols having 1 to 3 carbon atoms

Ethyl alcohol, isopropyl alcohol, etc. are mentioned as C1-C3 alcohol, It can be used individually by 1 type or in combination of 2 or more types. Especially, ethyl alcohol is preferable at the point of the odor at the time of use.

In the 1st sterilizing detergent composition of this invention, the compounding quantity ((total amount in the case of using 2 or more types) together) of (D) component is 16-40 mass% in a sterilizing detergent composition, and it is a shape | molding foam and rubs a hand together 20-30 mass% is preferable at the point of no post-waste debris. When less than 16 mass%, the ease of drying is bad, and when it exceeds 40 mass%, when it discharges from a former container, it does not become a bubble shape, it is difficult to get it, or it becomes a liquid immediately, and it becomes unsuitable to fall out of a hand when it arises. There is.

In the 2nd sterilizing detergent composition of this invention, the compounding quantity ((total amount in the case of using 2 or more types) together) of (D) component is 30-70 mass% in a sterilizing detergent composition, and it is a foam retention and hand 30-50 mass% is preferable at the point of no lather afterwards. At 50 mass% or more, easiness of drying is especially preferable. If it is less than 30 mass%, even if it rubs a hand, foam may not remain extinguished at a suitable time, and if it exceeds 70 mass%, even if it discharges from a foamer container, it will not become a foam and will get in a hand It may be difficult or inadequate to become liquid immediately and fall away from the hand.

Any component can be mix | blended with the germicidal detergent composition of this invention in the range which does not impair the effect of this invention. As an optional component, For example, solvents, such as a polyhydric alcohol, the fungicide except the (A) component and (D) component, an anti-inflammatory agent, such as a water-soluble high molecular compound and dipotassium glycyrrhinate, a coloring agent, a refreshing agent, and a coolant , Coloring agents, oils, silicones, pharmaceuticals such as vitamins, sugar alcohols such as sorbitol and erythritol, whitening agents, antioxidants, metal blockers, animal and vegetable extracts or derivatives thereof, inorganic powders, clay minerals, nylon And water-insoluble polymer powders such as polyethylene, water, and the like. These can be used individually by 1 type or in combination of 2 or more types, respectively, and can mix suitably in the range which does not impair the effect of this invention.

As polyhydric alcohol, polyethyleneglycol, 1, 3- butylene glycol, glycerin, etc. are mentioned, It is preferable to mix | blend 0-5 mass%. Although blending of polyhydric alcohols can prevent skin bumps, blending in excess of 5% by mass may cause skin stickiness after use.

Examples of the disinfectant except for the component (A) and the component (D) include isopropylmethylphenol, triclosan, trichlorocarbanilide, chlorhexidine hydrochloride, alkyldiaminoethylglycine, and octopyrox.

As a water-soluble high molecular compound, anionic high molecular compounds, such as an alkyl acrylate copolymer, cationic cellulose, dimethyl diallyl ammonium acrylamide copolymer, cationic high molecular compounds, such as a cation modified guar gum, hydroxypropyl methyl cellulose, acetic acid Nonionic high molecular compounds such as vinyl vinylpyrrolidone copolymer, amphoteric polymers such as dimethylallyl quaternary salt, acrylamide acrylamide vinylpyrrolidone N, N-dimethylaminoethyl, and the like.

As a coating agent, the coating composition which consists of a coating component, a solvent for a coating agent, and a coating stabilizer can be used. As content of a coating composition, 0.005-40 mass% is preferable in a sterilizing detergent composition, and 0.01-10 mass% is more preferable. A list of pharmaceutical raw materials used as pharmaceutical ingredients is described in various literatures such as "Perfume and Flavor Chemicals", Vol. I and II, Steffen Arctander, Allured Pub. Co. (1994); "Composite Chemicals and Product Knowledge," Indo-Umotoichi, Chemical Industry Daily (1996); Perfume and Flavor Materials of Natural Origin, Steffen Arctander, Allured Pub. Co. (1994); Encyclopedia of Scent, Japan Pharmaceutical Association, Asakura Bookstore (1989); Perfumery Material Performance V. 3.3, Boelens Aroma Chemical Information Service (1996); Flower oils and Floral Compounds In Perfumery, Danute Lajaujis Anonis, Allured Pub. Co. (1993) etc. are mentioned, for example, The said pharmaceutical component can be selected suitably from the pharmaceutical raw materials as described in these documents. Specifically, eucalyptus oil, camphor, borneo, lemon oil, lime oil, grapefruit extract, lavender oil, lavender extract, rosemary oil, rosemary extract, etc. are mentioned, for example.

As a solvent for a pharmaceutical, For example, ethanol, benzyl benzoate, acetin (triacetin), MMB acetate (3-methoxy-3-methylbutyl acetate), ethylene glycol dibutylate, hexylene glycol, dibutyl seba Kate, deltyl extra (isopropyl myristate), methyl carbitol (diethylene glycol monomethyl ether), carbitol (diethylene glycol monoethyl ether), TEG (triethylene glycol), benzyl benzoate, propylene glycol, diethyl phthalate , Tripropylene glycol, abolin (dimethyl phthalate), deltyl prime (isopurophyl palmitto), dipropylene glycol DPG-FC (dipropylene glycol), farnesene, dioctyl adipate, tributyrin (glyceryl tributa Noate), hydrolite-5 (1,2-pentadiol), propylene glycol diacetate, cetyl acetate (hexadecyl acetate), ethyl abietate, avalin (methyl abietate), citraflo A-2 (acetyltriethyl citrate), citroplex A-4 (tributylacetyl citrate), citroplex No. 2 (triethyl citrate), citroflex No. 4 (tributyl citrate) ), Dorafix (methyldihydroaviate), MITD (isotridecyl myristate), polylimonene (limonene polymer), 1, 3- butylene glycol, etc. are mentioned. As content of a solvent for pharmaceuticals, 0.1-99 mass% is preferable in a pharmaceutical composition, and 0.1-10 mass% is more preferable.

As a pharmaceutical stabilizer, dibutylhydroxytoluene, butylhydroxyanisole, vitamin E, its derivative (s), a catechin compound, a flavonoid compound, a polyphenol compound, etc. are mentioned, for example, Dibutylhydroxytoluene This is preferred. As content of a chemical stabilizer, 0.0001-10 mass% is preferable in a pharmaceutical composition, and 0.001-5 mass% is more preferable.

Menthol, peppermint oil, peppermint oil, etc. are mentioned as a refreshing agent. Specifically, N-ethyl paramentane carboxamide (brand name: WS3), l-menthyl glyceryl ether (brand name: CA-10), menthyl lactate (brand name: FrescolatML, FrescolatMGA), etc. are mentioned.

As a manufacturing method of the germicidal detergent composition of this invention, it is good to mix the said essential component, arbitrary components, and water (remainder), and there is no restriction | limiting in particular and it can select suitably according to the objective. Moreover, there is no restriction | limiting in particular as an apparatus which prepares a disinfecting detergent composition, The stirring apparatus provided with the some stirring blade (propeller, turbine, a disper etc.) which can be suitably selected according to the objective, and can be mixed with shearing force in whole is preferable. Do. There is no restriction | limiting in particular as a raw material of a sterilizing detergent composition, According to the objective, it can select suitably. In addition, each raw material may be used independently, and the mixture containing each raw material may be used.

As for pH of the germicidal detergent composition of this invention, 4-7 are preferable. This range is preferable at the point of skin mildness, and when pH7 is exceeded, there exists a possibility that antiseptic force may fall. It is preferable to use citric acid and sodium citrate for adjustment of pH. In addition, the pH of this invention is the value measured using the pH meter (HM-30G by Toago Radio Industry Co., Ltd.), and a pH electrode (GST-5721C type by Dong Aikeke Co., Ltd.) at 25 degreeC.

The germicidal cleaning agent composition of the present invention is liquid at room temperature, and the viscosity of the germicidal cleaning agent composition is preferably 30 mPa · s or less, more preferably 10 mPa · s or less under the temperature conditions to be used. In addition, the viscosity of this invention measured the value of 60 seconds at No.1 rotor rotation speed 60 degreeC using the rotational viscometer (former B8L made by Tokyo Instruments Co., Ltd.) at the temperature (temperature conditions to be used, 25 degreeC normally). to be.

The sterilizing detergent composition of the present invention is of a type that is not washed out, which is formed by filling a former container and discharged in a foam form. Since it is in the form of a bubble, it is easier to use than gel or spray and can be easily sterilized and washed in the absence of water. Moreover, it can also be set as the germicidal detergent product which has the germicidal detergent composition of the type which does not wash away, and a foamer container which accommodates this and discharges it in foam form.

As a foamer container, although the non-gas type bubble discharge container and the aerosol container using a propellant and a pressure-resistant container are mentioned, a non-gas type bubble discharge container is preferable. The non-gas type bubble discharge container is not particularly limited as long as it can mix the sterilizing detergent composition with air and discharge it in a foamed state. For example, bubbles can be discharged by squeezing the bottle eastern by hand. The squeeze foamer container which can be used, the pump foamer container which can discharge foam | bubble by pressing down a nozzle part, etc. are mentioned, It can select suitably according to the objective. As such a foamer container, things, such as a product made by Yamato-Kankan Co., Ltd., Yoshino Corporation, etc., can be used. More specifically, as a former container, the former container of Unexamined-Japanese-Patent No. 7-315463, 8-230961, Unexamined-Japanese-Patent No. 2005-193972, etc. can be used.

The non-gas type bubble discharge container has a bubble forming member, and specifically, has a porous membrane body (preferably a plastic material such as nylon, polyester or polyolefin) for forming bubbles. As the sterilizing detergent composition passes through the porous membrane body, bubbles are formed. There is no restriction | limiting in particular as a mesh of a porous membrane body, According to the objective, it can select suitably, For example, 100 mesh or more is preferable, 100-400 mesh is more preferable, 200-305 mesh is especially preferable. There is no restriction | limiting in particular as the number of sheets of a porous membrane body, 2-4 pieces are preferable from a viewpoint of selecting suitably according to the objective, and improving foaming performance. More specifically, the former container of Unexamined-Japanese-Patent No. 7-315463, 8-230961, and 2005-193972 can be used suitably. For example, when using a pump former container which can discharge foam by pressing down a nozzle part, and each of 305 and 200 mesh, the viscosity of a sterilizing detergent composition is 30 mPa * s or less under the temperature conditions to be used, 10 mPa * s or less is more preferable.

In the present invention, the type that does not wash off refers to a foamy sterilizing detergent composition obtained by hand, and used on the skin of a sterilizing and cleansing object, for example, a hand or the whole body, without being washed with water or the like. Although it does not specifically limit as a usage method, The method of taking a proper quantity 1-15 g in foam form several times a day, making it into a hand, and evenly spreading to a sterilization clean object, for example, a hand, the whole body, etc. is mentioned.

Example

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to the following Example. In addition, in the following example, when there is no specified in particular,% of a composition shows the mass%, a ratio shows the mass ratio, and all the component amounts described in the Example are pure part conversion.

[Examples 1 to 67, Comparative Examples 1 to 17]

The sterile detergent composition of the composition shown to Tables 1-14 was prepared according to the routine method, and the pH of the composition was adjusted to about 5.6. It was 1-9 mPa * s when the viscosity (25 degreeC) of the sterilizing detergent composition of an Example was measured for 60 second at No.1 rotor rotation speed using the rotational viscometer (made by Tokyo Instruments Co., Ltd., model B8L). . 200 g was filled in the former container of 250 mL of the obtained sterilizing detergent composition. The specification of this former container is based on the method of Unexamined-Japanese-Patent No. 2005-193972, and is brand name W-5721, WP. The FT L nozzle (made by Yoshino Corporation) was used. Specifically, the volume ratio of the gas / liquid: 13/1, the discharge amount: 1 g (1 push), the aperture is 5 mm x 8 mm (elliptical shape), the foaming member: 200 mesh and each one of the 305 mesh porous membrane body Was used.

[Formation of foam]

Under conditions of 25 ° C. and 60% RH, 1 g of a foamy sterilizing detergent composition was discharged from the foamer container onto the polyvinylidene chloride film, and the bubble height after 30 seconds after the discharge was measured. In this evaluation method, the thing less than 5 mm falls poorly in the case of poor foam retention, and when it is 20 mm or more, the bubble taken by hand does not disappear at a suitable time, and it is hard to rub it on a hand. That is, in terms of usability, preferred foam retaining properties and suitable defoaming times are 5 mm or more and less than 20 mm in this evaluation method. The result was shown by the following criteria based on the average value measured 3 times.

<Criteria>

◎: 16 mm or more and less than 20 mm

○: 13 mm or more and less than 16 mm

△: 5 mm or more and less than 13 mm

X: less than 5 mm or 20 mm or more

[No bubble after hand rubs]

Under conditions of 25 ° C. and 60% RH, 1 g of a foamy sterilizing detergent composition was discharged from the foamer container into the hands, and the hands were rubbed for about 10 seconds, and then the foam residue on the palms was evaluated. The result was sensory evaluation by ten professional panelists with the following rating, and was shown by the following criteria of criterion based on the average value of the rating.

<grade>

5 points: no bubble residue at all (within the allowable range)

4 points: Almost no bubble dregs (within the permissible range)

3 points | pieces: There is a little bubble dregs (within the permissible range)

2 points | pieces: There is considerably bubble dregs (outside tolerance)

1 point: Bubbles increase (outside the acceptable range)

<Criteria>

◎: 4.0 or more

○: 3.0 or more and less than 4.0

△: 2.0 or more and less than 3.0

×: less than 2.0

[Ease of Drying]

Under the conditions of 25 ° C. and 60% RH, 1 g of the foam-type sterilizing detergent composition was discharged from the foamer container into the hand, and the time until the liquid dries was measured while rubbing on the back of the hand and the hand. The result was sensory evaluation by ten professional panels, and was shown by the following determination criteria based on the average value of the time.

<Criteria>

◎: less than 30 seconds (within the allowable range)

○: 30 seconds or more but less than 60 seconds (within the allowable range)

△: 60 seconds or more and less than 90 seconds (outside the allowable range)

×: 90 seconds or more (outside the allowable range)

[Sterilization (sterilization rate (減 菌 率) (%)]]

Three fingers of one hand were plated on a standard agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.) to collect bacteria before use. Thereafter, 1 g of sterile detergent composition was taken on the other hand, rubbed on the finger until the juice dries, and then three fingers were plated on a standard agar medium to collect the used bacteria (Strike plate method). Colonies of fingers before and after use of the sterilizing detergent composition were incubated at 37 ° C. for 24 hours, and the number of colonies was measured. , Number of colonies before use (A ₀₎ according to the following equation, and then the sense of use was shown gyunryul from the colony number (A _1). It is effective to have a sterilization rate of 95% or more and less than 70%.

Infection Rate (%) = (1-A ₁ / A ₀ ) × 100

TABLE 1

* 1: The alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

* 2: alkyl chain length (R ² ) is C16

* 3: A hydrocarbon group having an ether bond (R ¹ ) is C ₁₈ H ₂₉ O ₂

TABLE 2

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

[Table 3]

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

[Table 4]

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

TABLE 5

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

TABLE 6

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

* 2: alkyl chain length (R ² ) is C16

TABLE 7

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

* 2: alkyl chain length (R ² ) is C16

* 3: A hydrocarbon group having an ether bond (R ¹ ) is C ₁₈ H ₂₉ O ₂

[Table 8]

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

TABLE 9

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

* 2: alkyl chain length (R ² ) is C16

* 3: A hydrocarbon group having an ether bond (R1) is C ₁₈ H ₂₉ O ₂

TABLE 10

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

TABLE 11

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

TABLE 12

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

TABLE 13

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

* 2: alkyl chain length (R ² ) is C16

[Table 14]

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

Example 68

According to the following composition, the systemic sterilizing detergent composition of Example 68 was prepared by the routine method. The obtained whole body sterilizing detergent composition was filled in the former container similarly to Example 1, and it evaluated similarly. (pH5.6, viscosity (25 ° C), 4 mPas)

TABLE 15

Furtherance %

Benzalkonium Chloride * 1 0.05

Polyoxyethylene (60) hardened castor oil (HLB14) 0.5

dl-pyrrolidone carbonate 0.5

Dipotassium glycyrrhizinate 0.25

Ethyl alcohol 20

Citric Acid 0.25

Sodium Citrate 0.7

Purified water balance

-------------------------------------------------- -

100.0 total

* 1: alkyl chain length (R ¹ ) is C12 / C14 = 63/37 (mass ratio)

(Evaluation results)

Foam Formation: ◎

No lather after hand rub: ◎

Ease of Drying: ○

Infection Rate: 99%

The raw material used when preparing the Example and the comparative example is shown below.

(1) Benzalkonium Chloride: Nissan Cation F2-50E

* 1: The alkyl chain length (R ¹ ) is C 12 / C 14 = 63/37 (mass ratio)

(2) Cetylpyridinium Chloride: Wakojunyaku Industry Co., Ltd., cetylpyridinium chloride

* 2: Alkyl chain length (R ² ) is C16

(3) Benzetonium chloride: crystals of hyamine from Mitsubishi Chemical Foods Co., Ltd.

* 3: A hydrocarbon group having an ether bond (R ¹ ) is C ₁₈ H ₂₉ O ₂

(4) Polyoxyethylene (20) Cured castor oil (PEG-20 Cured castor oil): Japan Emulsion Co., Ltd., EMALEX HC-20

(5) Polyoxyethylene (40) hardened castor oil (PEG-40 hardened castor oil): Japan Emulsion Co., Ltd., EMALEX HC-40

(6) Polyoxyethylene (60) hardened castor oil (PEG-60 hardened castor oil): Japan Emulsion Co., Ltd., EMALEX HC-60

(7) Polyoxyethylene (100) Cured Castor Oil (PEG-100 Cured Castor Oil): Japan Emulsion Co., Ltd., EMALEX HC-100

(8) Stearic acid PEG-10: Japan Emulsion Co., Ltd., EMALEX810

(9) Stearic acid PEG-20: Japan Emulsion Co., Ltd., EMALEX820

(10) Stearic acid PEG-40: Japan Emulsion Co., Ltd., EMALEX840

(11) stearic acid PEG-10 glyceryl: Japan Emulsion Co., Ltd., EMALEX GM-10

(12) stearic acid PEG-15 glyceryl: Japan Emulsion Co., Ltd., EMALEX GM-15

(13) Stearate PEG-40 Glyceryl: Japan Emulsion Co., Ltd., EMALEX GM-40

(14) dl-pyrrolidone carboxylic acid sodium Ajinomoto Co., Ltd. make, PCA soda

(15) Lysine: Ajinomoto Co., Ltd., hydrochloric acid L-lysine

(16) Serine: Kyowa Fermentation Co., Ltd., L-serine

(17) Polyoxyethylene (10) Cured castor oil (PEG-10 Cured castor oil): Japan Emulsion Co., Ltd., EMALEX HC-10

(18) Stearic acid PEG-150: Japan Emulsion Co., Ltd., EMALEX 6300M-ST

(19) imidazolinium betaine: Ovazorin 662N, manufactured by Dongbu Chemical Co., Ltd.

(20) Polyoxyethylene (10) cholesteryl ether: Japan Emulsion Co., Ltd., EMALEX CS-10

(21) Polyoxyethylene (15) decyl tetradecyl ether: Japan Emulsion Co., Ltd., EMALEX 2415

(22) Polyoxyethylene (10) octyldodecyl ether: Japan Emulsion Co., Ltd., EMALEX OD-10

(23) Polyoxyethylene (20) octyldodecyl ether: Japan Emulsion Co., Ltd., EMALEX OD-20

(24) Polyoxyethylene (25) octyldodecyl ether: Japan Emulsion Co., Ltd., EMALEX OD-25

(25) Polyoxyethylene (5) cholesteryl ether: Japan Emulsion Co., Ltd., EMALEX CS-5

(26) Polyoxyethylene (10) decyl tetradecyl ether: Japan Emulsion Co., Ltd., EMALEX 2410

(27) Polyoxyethylene (20) isocetyl ether: Japan Emulsion Co., Ltd., EMALEX 1620

Claims (3)

(A) a cationic fungicide, (B-1) nonionic surfactant selected from polyoxyethylene hardened castor oil of HLB9-16, monostearic acid polyoxyethyleneglycerin and monostearic acid polyethyleneglycol, (C) amino acid or its salt, And (D) 16 to 40% by mass of alcohols having 1 to 3 carbon atoms, which are filled in a former container and discharged in the form of bubbles, wherein the disinfecting detergent composition of the non-washable type is used. (A) Cationic fungicide, (B-2) the following general formula (1) of HLB10-14

(In formula, m is 6-10, n represents the integer of 10-25.)
Nonionic surfactants selected from polyoxyethylene branched alkyl ethers and polyoxyethylene cholesteryl ethers, (C) amino acids or salts thereof, and (D) 30 to 70 mass% of alcohols having 1 to 3 carbon atoms. A sterilizing detergent composition of a non-washable type, characterized in that it is filled into a former container and discharged in a foam form. 3. The method according to claim 1 or 2,
(A) A component is benzalkonium chloride, benzetonium chloride, or cetylpyridinium chloride, The sterilizing detergent composition characterized by the above-mentioned.