KR20080109328A - Apparatus of measuring glucose concentration by using optical coherence tomography and method for operating the apparatus - Google Patents

Abstract

A blood sugar density measurer using an optical tomography technique and a method thereof are provided to measure the quantity of water of measurement position of blood-sugar density by using an optical sensor and correct blood-sugar density through the quantity of water so that the blood-sugar density is accurately measured. A blood sugar density measurer using a optical tomography technique(OCT: Optical Coherence Tomography) comprises an emitting device(307), a photodetector(308), a quantity of water information unit(309) and a blood-sugar density correction(310). The emitting device irradiates light in a measurement position. The photodetector detects a scattering optical signal scattered in the skin tissue of the measurement position. The photodetector converts the scattering optical signal into an electric signal. The quantity of water information unit produces the quantity of water information of the measurement position from the electric signal. The blood-sugar density correction corrects the blood-sugar density of the measurement position through the quantity of water information.

Description

Apparatus and method for measuring blood glucose concentration using optical tomography technique {APPARATUS OF MEASURING GLUCOSE CONCENTRATION BY USING OPTICAL COHERENCE TOMOGRAPHY AND METHOD FOR OPERATING THE APPARATUS}

1 is a view schematically showing the configuration of a blood sugar concentration measuring apparatus according to an embodiment of the present invention.

Figure 2 is a schematic diagram for explaining the principle of measuring OCT used in the blood glucose concentration measuring apparatus according to the present invention.

Figure 3 is a block diagram showing the configuration of a blood sugar concentration measuring apparatus according to an embodiment of the present invention.

4 illustrates an example of a contact surface of a scan probe according to an embodiment of the present invention.

5 is a view showing an example of a measuring fixture according to an embodiment of the present invention.

6 is a view showing the arrangement of the light emitting device and the photo detector according to an embodiment of the present invention.

Figure 7 is a graph showing the correlation between blood glucose concentration and water content according to an embodiment of the present invention.

Figure 8 is a flow chart showing the flow of blood glucose concentration measurement method through the amount of water correction according to an embodiment of the present invention.

<Explanation of symbols for the main parts of the drawings>

301: light generator 302: beam splitter

303: scan probe 304: reference signal generator

305: blood sugar concentration measuring unit 306: blood collecting device

307: light emitting element 308: photo detector

309: water content information unit 310: blood sugar concentration correction unit

The present invention relates to an apparatus and method for measuring blood glucose concentration using optical coherence tomography (OCT), and more specifically, to measuring blood glucose concentration using an optical sensor together with measurement of blood glucose concentration using an OCT. The present invention relates to an apparatus and method for measuring blood glucose concentration using optical tomography (OCT), which guarantees a more accurate measurement of blood glucose concentration by measuring the amount of water and correcting the blood glucose concentration through the water amount.

Today, an improved living environment has led to an increase in adult diseases, which has resulted in higher health concerns for users than in the past. Diabetes, one of such adult diseases, is gradually increasing in number of patients. Diabetes releases glucose into the urine due to a higher concentration of glucose (blood sugar) in the blood due to a lack of insulin in the body, which causes patients with diabetes to control blood glucose levels in the blood for about 6 days a day. You need to monitor your blood sugar about once.

In addition, the blood glucose is one of the very important factors informing the state of health in the normal case of 70 ~ 110mg / dℓ (mg amount per 100cm3) and 180mg / dℓ or less after meals, and maintains more than 60mg / dℓ during starvation. However, when blood sugar levels rise above the normal level, dehydration symptoms such as thirst and frequent urination appear, and when they fall below the normal level, symptoms of anxiety and dizziness occur. In severe cases, death can result. For this reason, the general public needs diabetic patients to measure the blood sugar periodically and maintain the proper blood sugar level for the purpose of measuring the state of health.

In the conventional method of measuring blood glucose, a user invades blood in the body invasively, and for example, a blood glucose level is measured by a blood glucose meter using an enzymatic method. Diabetes patients measure blood glucose levels by measuring blood glucose levels with acupuncture needles about six times a day, which can cause pain and discomfort during the blood collection process, or they may be infected with a disease. Regular inspections were a big burden.

In addition, in the case of using a blood glucose meter, since an additional article such as a disposable test paper or a disposable syringe is necessarily used, there is a problem of increasing the economic burden of purchasing additional articles for the general public or diabetics. Therefore, various methods for non-invasive measurement of blood glucose levels have been proposed to solve the conventional method.

For example, US Pat. No. 6,725,073, which is registered with the U.S. Patent Office, discloses a method for non-invasively measuring blood glucose levels using optical coherence tomography (OCT). However, the measurement method is used for the skin, sclera, lip, and the like to measure blood glucose levels, so if there is motion in the site, the effect of moving artifacts is affected. It was difficult to measure the exact blood glucose level.

Also, at least 90% of the components of skin tissue are made up of water. Therefore, in measuring the blood glucose concentration non-hygroscopically, the moisture content can have a great influence on noise.

Accordingly, there is a need for the development of a technology for more accurately measuring blood glucose levels in consideration of the moisture content of skin tissue when measuring blood glucose concentration using OCT.

The present invention has been made to improve the prior art as described above, by measuring the water content of the blood glucose concentration measurement site using an optical sensor with the measurement of blood sugar concentration using OCT, and corrects the blood glucose concentration through the water content Accordingly, an object of the present invention is to provide an apparatus and method for measuring blood glucose concentration using optical tomography (OCT), which ensures more accurate blood glucose concentration measurement.

In order to achieve the above object and solve the problems of the prior art, the blood glucose concentration measuring apparatus using the OCT according to the present invention, the light emitting element for irradiating light to the measurement site; A photo detector for detecting scattered light signals in the biological tissue of the measurement site and converting the scattered light signals into electrical signals; A moisture content information unit configured to generate moisture content information of the measurement part from the electrical signal; And a blood sugar concentration correction unit for correcting the blood sugar concentration of the measurement site through the water content information.

In addition, the blood glucose concentration measuring method using the OCT according to the present invention, the step of irradiating light to the measurement site; Detecting the scattered light signal in the biological tissue of the measurement site and converting the scattered light signal into an electrical signal; Generating water content information of the measurement part from the electrical signal; And correcting the blood glucose concentration of the measurement site through the water content information.

Hereinafter, a blood glucose concentration measuring apparatus using optical coherence tomography (OCT) according to the present invention will be described in detail with reference to the accompanying drawings.

1 is a view schematically showing the configuration of a blood sugar concentration measuring apparatus according to an embodiment of the present invention.

As shown in FIG. 1, the blood glucose concentration measuring apparatus 100 generates light through a predetermined light source 110, and the light generated from the light source 110 is first and second in the beam splitter 120. Split into beams The light source 110 may be any one of a light emitting diode (LED), a super luminescent diode (SLD), a laser diode (LD), or a package LED module.

The first beam separated by the beam splitter 120 is received by the scan probe 140, and the scan probe 140 irradiates the first beam to the measurement site where the blood is collected through the blood collecting device 150. In addition, one or more backscattered signals that are backscattered from the measurement site are received and transmitted to the beam splitter 120.

The blood collection device 150 is a means for applying pressure to the periphery of the measurement site so that blood is collected at the measurement site. The blood collection device 150 may compress or release the periphery of the measurement site according to a user's operation. It may be implemented.

According to another embodiment of the present invention, the blood collecting device 150 further includes a small blood pressure measuring device, and the blood pressure measuring device uses the blood collecting device 150 to press or release the blood sugar according to the present invention. The blood pressure of the user may be measured in conjunction with or separately from the concentration measuring apparatus 100.

The beam splitter 120 receives the backscattered signal from the scan probe 140 and receives the reflected reference signal by irradiating the second beam to the reference mirror 130. The blood glucose concentration measuring apparatus 100 generates an OCT signal for each depth from the interference signal of the backscattering signal and the reference signal, and differentially calculates the OCT signal to measure blood glucose concentration. The method of measuring blood glucose concentration using the OCT signal generation and the generated OCT signal will be described with reference to FIG. 2.

Figure 2 is a schematic diagram for explaining the principle of measuring OCT used in the blood glucose concentration measuring apparatus according to the present invention.

Referring to FIG. 2, the first beam 201 is irradiated to the measurement site through the scan probe 140 described above with reference to FIG. 1, and three backscattered signals 202 scattered at the measurement site are obtained. One or more such backscattering signals are generated due to the change in the refractive index of the skin tissue, which is the measurement site, with different tissue layers. Of these backscattering signals, a reference signal 203 at a particular depth of penetration is used to obtain a backscattered signal that is backscattered at a particular depth of penetration in which blood is concentrated. In this way, the backscattered signal backscattered at a specific transmission depth is correlated with the reference signal to obtain a predetermined interference signal. The interference signal thus obtained becomes the OCT signal 204. By calculating the gradient change of the OCT signal 204, the blood glucose concentration at the measurement site can be obtained.

Figure 3 is a block diagram showing the configuration of a blood glucose concentration measuring apparatus according to an embodiment of the present invention.

The blood sugar concentration measuring apparatus 300 according to an embodiment of the present invention includes a light generator 301, a beam splitter 302, a scan probe 303, a reference signal generator 304, and a blood sugar concentration measurer 305. ), A blood collection device 306, a light emitting element 307, a photo detector 308, a moisture content information unit 309, and a blood sugar concentration correction unit 310.

The light generator 301 generates light using any one of a predetermined light source, for example, a light emitting diode (LED), a super luminescent diode (SLD), a laser diode (LD), or a package LD module.

The beam splitter (BS) 302 splits the light generated from the light generator 201 into first and second beams having the same amount of light. For example, the beam splitter 302 may split light generated from the light generator 301 in a 50:50 ratio.

The scan probe 303 irradiates the first beam to a measurement site where blood is collected through the blood collection device 306, and receives a back-scattered backscattering signal at the measurement site. do. Scan probe 303 according to an embodiment of the present invention may be designed in the form of a pen.

The blood collection device 306 is a means for applying pressure to the periphery of the measurement site so that blood is collected at the measurement site. The blood collection device 306 may compress or release the periphery of the measurement site according to a user's operation. It may be implemented. The backscattering signal refers to a scattering signal in which some of the scattering signals generated by the first beam are irradiated and reflected in the direction in which the first beam is irradiated.

According to a preferred embodiment of the present invention, the measurement site to which the first beam is irradiated may be a site, in particular a fingernail, which minimizes a movement barrier in epithelial tissue of the human body. If the measurement site is a nail, the user wears a blood lump device 306 on the lower finger portion of the nail, and the blood lump device 306 is a position where the blood lump device is worn so that blood is collected at the nail site The pressure may be applied to a predetermined pressure.

The scan probe 303 irradiates the first beam to the nail where the blood is collected, and receives a back-scattering signal that is back-scattered from the nail. Therefore, the blood glucose concentration measuring device for measuring the blood sugar concentration on the nail by increasing the blood volume to the nail region through the blood gathering mechanism 306 may improve the accuracy of blood sugar concentration measurement.

According to another embodiment of the present invention, the shape of the contact surface where the scan probe 303 contacts the measurement site may be a curved surface 301 according to the curvature of the nail as shown in FIG. 4. This is to allow the scan probe 203 to be in close contact with the nail area since human nails usually have a predetermined radius of curvature. As such, when the shape of the contact surface of the scan probe 203 is the curved surface 301 according to the curvature of the nail, the above-described moving artifacts can be reduced.

According to another embodiment of the present invention, the blood glucose concentration measuring apparatus 300 may further include a predetermined measuring fixing device (not shown) designed to be detachably attached to the nail. The measurement fixing device may be detachable to the nail region and may include a cavity having a contact surface size of the scan probe. A detailed example of the measuring fixture is described below with reference to FIG. 5.

5 is a view showing an example of a measuring fixture according to an embodiment of the present invention.

As shown in FIG. 5, the measuring fixture is detachable to the fingernail and includes a cavity 501 according to the size of the contact surface in which the scan probe 303 shown in FIG. 3 contacts the fingernail. The joint position of the measurement fixing device may be a site where blood volume is concentrated in the nail. Scan probe 303 also contacts the fingernail through cavity 501 of the measurement fixture. Since the scan probe 303 is in close contact with the nail surface through the cavity of the measurement fixing device, the movement of the scan probe 303 may be minimized even when the user moves.

The reference signal generator 304 irradiates the second mirror beam split from the beam splitter 302 to a reference mirror. The reference signal generator 304 generates one or more reference signals by irradiating the second beam, which corresponds to the transmission depth information of the first beam irradiated to the measurement part from the scan probe 303. It may be one or more signals. In order to generate the at least one reference signal, the reference signal generator 304 includes a predetermined actuator means to displace the reference mirror so as to correspond to the transmission depth information of the first beam. The above reference signal can be obtained.

According to another embodiment of the present invention, the reference signal generator 304 applies a predetermined strain to an optical fiber connected to the reference signal generator 304 instead of an actuator means for displacing the reference mirror. As a result, the same reference signal as the actual displacement of the reference mirror may be obtained.

The beam splitter 302 receives the backscattered signal generated by the scan probe 303 and the reference signal generated by the reference signal generator 304, and may be a transducer such as a photo diode (PD). The means converts the optical signal into an electrical signal.

The blood sugar concentration measuring unit 305 generates an OCT signal from an interference signal of a backscattered signal converted into an electrical signal and a reference signal corresponding to specific transmission depth information, and differentially calculates the OCT signal to determine the blood sugar concentration of the measurement site. Measure The OCT signal refers to a signal generated by inducing an interference effect between the backscattered signal and the reference signal at a specific transmission depth point by correlating the backscattered signal with the reference signal. The differential calculation of the OCT signal is for measuring a change in the slope of the OCT signal, and the blood glucose concentration at the specific point may be measured through the change in the slope. As described above, the method for calculating the blood glucose level by measuring the change in the slope of the OCT signal is a well-known method, and thus a detailed description thereof will be omitted.

The light emitting element 307 irradiates light to the measurement site. The light emitting device 307 may include one or more LEDs. For example, the light emitting device 307 may be composed of one chip LED, or a plurality of LEDs may be configured in a multi array form.

In addition, the light emitting element 307 irradiates light having a water absorption wavelength band to the measurement site. For example, the light emitting device 307 may be implemented to irradiate light having a wavelength of 749 nm to the measurement site.

The light emitting device 307 and the photo detector 308 are spaced apart from each other in opposite directions with respect to the scan probe 303. This will be described with reference to FIG. 6.

FIG. 6 is a view illustrating an arrangement form of a light emitting device and a photo detector according to an embodiment of the present invention.

As illustrated in FIG. 6, the light emitting device 610 and the photo detector 620 may be spaced apart in opposite directions with respect to the scan probe 630. The separation distance d between the light emitting device 610 and the photo detector 620 is the light detector 620 after the light 640 irradiated from the light emitting device 610 is transmitted to the dermis and scattered, the photo detector 620 may detect the scattered light. It can be set to a distance.

That is, light 640 irradiated from the light emitting device 610 may be scattered in the epidermis and the dermis in the skin tissue. The irradiation depth z of the light 640 irradiated into the skin tissue may be determined according to the separation distance d between the light emitting device 610 and the photo detector 620. For example, the irradiation depth z may be determined as 1/3 of the separation distance d. Therefore, according to a preferred embodiment of the present invention, the separation distance d may be set to about 6mm, so that the irradiation depth z is set to 2mm to 3mm.

3 again, the photo detector 308 detects the scattered light signal scattered in the skin tissue of the measurement site and converts the scattered light signal into an electrical signal. To this end, the photo detector 308 may be implemented to include an optical-electrical transducing element that converts an optical signal into an electrical signal.

The water content information unit 309 generates water content information of the measurement site from the electric signal. That is, the moisture content information unit 309 may measure the moisture content of the skin tissue in the measurement site through the electrical signal received from the photo detector 308 and generate moisture information from the moisture amount. The moisture content information may be implemented in percentage units. The operation of the moisture amount information unit 309 for measuring the amount of moisture from the scattering light signal may be implemented including all of the method for measuring the amount of moisture using an optical sensor of various methods widely used in the art.

The blood sugar concentration correction unit 310 corrects the blood sugar concentration of the measurement site through the moisture content information. That is, the blood sugar concentration correcting unit 310 may correct the blood sugar concentration measured by the blood sugar concentration measuring unit 305 using the water amount information measured by the water amount information strain 309. To this end, the blood sugar concentration correcting unit 310 may maintain correlation information between the predetermined blood sugar concentration and the amount of water. The correlation information between the blood glucose concentration and the water content may be implemented in a graph form, which will be described with reference to FIG. 7.

7 is a graph showing a correlation between blood sugar concentration and water content according to an embodiment of the present invention.

As shown in the graph of FIG. 7, the blood glucose concentration measured at the same measurement site may vary depending on the moisture content of skin tissue in the measurement site. For example, even in the same measurement site, the blood glucose concentration may be measured as a when the moisture content of the skin tissue in the measurement site is 10%, and the blood sugar concentration may be measured as b when the moisture content is 20%. If the moisture content is 30%, the blood glucose level can be measured by c.

As such, blood glucose concentration and water content are inversely correlated. In the graph of FIG. 7, as is well known in the art, an appropriate amount of moisture that does not significantly affect the measurement of accurate blood glucose concentration may be set, for example, to about 20%. The appropriate amount of moisture is only one example for convenience of description, and may be set to various values according to the judgment and experimental results of those skilled in the art. However, in the present specification, for convenience of description, the case where the appropriate moisture amount has a value of about 20% as shown in FIG. 7 will be described as an example.

The blood sugar concentration correction unit 310 may correct the measured blood sugar concentration by using the correlation between the blood sugar concentration and the water content. For example, when the moisture content of the measurement site measuring the blood glucose concentration is 10%, the blood sugar concentration correction unit 310 subtracts the difference between the blood sugar concentration a and the blood sugar concentration b from the measured blood sugar concentration, thereby Can be corrected.

In addition, when the moisture content of the measurement site measuring the blood sugar concentration is 30%, the blood sugar concentration correction unit 310 corrects the blood sugar concentration by summing the difference between the blood sugar concentration b and the blood sugar concentration c from the measured blood sugar concentration. can do. Thus, by correcting the blood glucose concentration according to the amount of water, more precise non-invasive blood glucose concentration can be expected.

8 is a flowchart illustrating a flow of a blood glucose concentration measuring method through water content correction according to an embodiment of the present invention.

First, in step 811, the blood glucose concentration measuring apparatus generates light using a light source.

In operation 812, the blood glucose concentration measuring apparatus splits the light generated from the light generator into a first beam and a second beam having the same amount of light through a beam splitter.

In operation 813, the apparatus for measuring blood glucose concentration irradiates the first beam to a measurement site where blood is collected through a blood collection device, and receives a backscattered signal that is backscattered from the measurement site. The blood collection device is a means for applying pressure around the measurement site such that blood is collected at the measurement site. The measurement site according to an embodiment of the present invention may be a nail.

In operation 814, the apparatus for measuring blood glucose concentration irradiates the second beam to a reference mirror, and generates a reference signal from reflected light of the reference mirror that is displaced by a predetermined actuator. . According to another embodiment of the present invention, step 814 is applied by applying a predetermined strain to the optical fiber connected to the reference signal generator 304 instead of actuator means for displacing the reference mirror. It may be a step of obtaining one or more reference signals, which are the same as the actual displacement of the mirror.

In operation 815, the blood glucose concentration measuring apparatus generates an OCT signal from the interference signal between the backscattering signal and the reference signal, and differentially calculates the OCT signal to measure the blood glucose level of the measurement site.

In addition to the blood glucose concentration measurement of steps 811 to 815, the blood sugar concentration measuring apparatus may measure the moisture content of the measurement site through steps 816 to 819.

The blood glucose concentration measuring apparatus irradiates light to the measurement site for measuring the blood sugar concentration (step 816). The light may be implemented as light having a wavelength of 749 nm. The blood glucose concentration measuring apparatus detects scattered light signals scattered from the biological tissue of the measurement site (step 817), and converts the scattered light signals into electrical signals (step 818). The blood glucose concentration measuring apparatus generates water content information of the measurement site from the electrical signal (step 819).

The blood sugar concentration measuring apparatus corrects the blood sugar concentration of the measurement site through the water content information (step 820). That is, the blood glucose concentration measuring apparatus may correct the blood sugar concentration measured in step 815 using the correlation information between the moisture content information generated in step 819 and the predetermined blood glucose concentration and water content.

The method for measuring blood glucose concentration using optical tomography (OCT) according to the present invention may be implemented in the form of program instructions that can be executed by various computer means and recorded in a computer readable medium. The computer readable medium may include program instructions, data files, data structures, etc. alone or in combination. Program instructions recorded on the media may be those specially designed and constructed for the purposes of the present invention, or they may be of the kind well-known and available to those having skill in the computer software arts. Examples of computer-readable recording media include magnetic media such as hard disks, floppy disks, and magnetic tape, optical media such as CD-ROMs, DVDs, and magnetic disks, such as floppy disks. Magneto-optical media, and hardware devices specifically configured to store and execute program instructions, such as ROM, RAM, flash memory, and the like. The medium may be a transmission medium such as an optical or metal wire, a waveguide, or the like including a carrier wave for transmitting a signal specifying a program command, a data structure, or the like. Examples of program instructions include not only machine code generated by a compiler, but also high-level language code that can be executed by a computer using an interpreter or the like. The hardware device described above may be configured to operate as one or more software modules to perform the operations of the present invention, and vice versa.

While specific embodiments of the present invention have been described so far, various modifications are possible without departing from the scope of the present invention.

Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined not only by the claims below, but also by the equivalents of the claims.

According to the apparatus and method for measuring blood glucose concentration using the optical tomography technique (OCT) of the present invention, by measuring the water content of the blood glucose concentration measurement site using an optical sensor together with the measurement of blood glucose concentration using OCT, By correcting the blood glucose concentration, it is possible to obtain an effect of ensuring a more accurate measurement of blood glucose concentration.

As described above, the present invention has been described by way of limited embodiments and drawings, but the present invention is not limited to the above-described embodiments, which can be variously modified and modified by those skilled in the art to which the present invention pertains. Modifications are possible. Accordingly, the spirit of the present invention should be understood only by the claims set forth below, and all equivalent or equivalent modifications thereof will belong to the scope of the present invention.

Claims (17)

In the blood glucose concentration measuring apparatus using optical coherence tomography (OCT), A light emitting device for irradiating light to the measurement site; A photo detector for detecting scattered light signals from skin tissue of the measurement site and converting the scattered light signals into electrical signals; A moisture content information unit configured to generate moisture content information of the measurement part from the electrical signal; And Blood sugar concentration correction unit for correcting the blood sugar concentration of the measurement portion through the moisture information Blood sugar concentration measuring apparatus using an OCT comprising a. The method of claim 1, The light emitting device includes at least one LED, and the blood glucose concentration measuring apparatus using the OCT, characterized in that for irradiating the light having a wavelength of 749nm to the measurement site. The method of claim 1, Light generating unit; A beam splitter (BS) for splitting the light generated from the light generator into a first beam and a second beam; A scan probe for irradiating the first beam to a measurement site where blood is collected through a blood collection device and receiving one or more backscattering signals backscattered at the measurement site; A reference signal generator for irradiating the second beam to a reference mirror and generating at least one reference signal corresponding to transmission depth information of the first beam from reflected light of the reference mirror; And A blood glucose concentration measurement unit configured to generate an optical coherence tomography (OCT) signal corresponding to the transmission depth information from the interference signal of the backscattering signal and the reference signal, and differentially calculate the OCT signal to measure blood glucose concentration at the measurement site Including, The blood aggregation apparatus is a blood glucose concentration measuring apparatus using the OCT, characterized in that the means for applying a pressure around the measurement site to collect blood in the measurement site. The method of claim 3, The light emitting device and the photo detector are each provided with a blood glucose concentration measuring apparatus, characterized in that spaced apart in opposite directions with respect to the scan probe. The method of claim 1, The light emitting device and the photo detector is a blood glucose concentration measuring device using an OCT, characterized in that spaced apart by a distance of 6mm. The method of claim 1, The blood sugar concentration correcting unit corrects the blood sugar concentration of the measurement site using the water content using the correlation information between the predetermined (predetermined) blood sugar concentration and the amount of water. The method of claim 3, And the reference signal generator includes a predetermined actuator means for displacing the reference mirror. The method of claim 3, And the reference signal generator generates the reference signal corresponding to the depth information by applying a strain to an optical fiber connected to the reference mirror. The method of claim 3, The blood aggregation apparatus further comprises a blood pressure measuring device, blood glucose concentration measuring apparatus using the OCT. The method of claim 3, The measurement site is a blood glucose level measurement apparatus using an OCT, characterized in that the nail. The method of claim 9, The shape of the contact surface that the scan probe is in contact with the measurement site is a blood glucose concentration measuring apparatus using an OCT, characterized in that the curved surface corresponding to the curvature of the nail. The method of claim 9, And a measuring fixture detachable to the nail and including a cavity of the contact surface size of the scan probe, And the scan probe is in contact with the nail through the cavity of the measuring fixture. In the blood glucose concentration measuring method using optical coherence tomography (OCT), Irradiating light to the measurement site; Detecting the scattered light signal in the biological tissue of the measurement site and converting the scattered light signal into an electrical signal; Generating water content information of the measurement part from the electrical signal; And Correcting the blood glucose concentration of the measurement site through the water content information Blood glucose concentration measurement method using an OCT comprising a. The method of claim 13, The light has a wavelength of 749nm, the method of measuring blood glucose concentration using OCT. The method of claim 13, Correcting the blood glucose concentration of the measurement site through the water content information, Maintaining correlation information between a predetermined blood glucose concentration and a water content; And Correcting the blood glucose concentration of the measurement site by using the correlation information Blood glucose concentration measurement method using an OCT comprising a. The method of claim 13, Generating light in the light generating unit; Dividing the light generated from the light generating unit into a first beam and a second beam having the same amount of light in a beam splitter; Irradiating the first beam through a scan probe to a measurement site where blood is collected through a predetermined blood collection device, and receiving one or more backscattering signals backscattered at the measurement site; Irradiating the second beam to a reference mirror and generating a reference signal corresponding to a transmission depth of the first beam from reflected light of the reference mirror; And Generating an OCT signal corresponding to the transmission depth from the interference signal of the backscattering signal and the reference signal, and differentially calculating the OCT signal to measure blood glucose concentration of the measurement site Including, The blood aggregation apparatus is a blood glucose concentration measuring method using the OCT, characterized in that the means for applying a pressure around the measurement site to collect blood in the measurement site. A computer-readable recording medium having recorded thereon a program for executing the method of claim 13.

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