KR102622691B1 - Cosmetic Composition For Prohibiting Skin Aging By Light Comprising Acer Tegmentosum And Fraction From Thereof As Active Ingredient - Google Patents

Abstract

The present invention relates to a cosmetic composition containing Acer tegmentosum extract and tyrosol, an isolated compound thereof, as active ingredients, and specifically to a cosmetic composition that effectively improves skin aging caused by light. The cosmetic composition has the effect of improving skin wrinkles by effectively reducing the activity of collagen degrading enzymes induced by UV and IR for skin aging caused by light, which is one of the causes of skin aging.

Description

Cosmetic composition for preventing skin aging caused by light containing bee tree extract and its isolated compounds as active ingredients {Cosmetic Composition For Prohibiting Skin Aging By Light Comprising Acer Tegmentosum And Fraction From Thereof As Active Ingredient}

The present invention relates to a cosmetic composition containing Acer tegmentosum extract and tyrosol, an isolated compound thereof, as active ingredients, and specifically to a cosmetic composition that effectively improves skin aging caused by light. The cosmetic composition has an effect of improving skin wrinkles by effectively reducing the activity of collagen decomposition enzyme induced by ultraviolet rays or infrared rays in response to skin aging caused by light, which is one of the causes of skin aging.

Human skin undergoes various physical and chemical changes during the aging process. The causes are largely divided into intrinsic aging and photo-aging, and research on these has been actively conducted. It can be caused by the activation of free radicals due to ultraviolet rays, stress, disease states, environmental factors, wounds, and aging. If this condition worsens, it destroys the antioxidant defense network that exists in the body and damages cells and tissues, causing adult diseases. and accelerates aging. More specifically, the major components of skin, such as lipids, proteins, polysaccharides, and nucleic acids, are oxidized, destroying skin cells and tissues, and ultimately causing skin aging.

A person's skin color is determined by melanin, hemoglobin, and carotene, of which melanin plays the most important role. In addition to determining a person's skin color, melanin also performs skin protection functions such as absorbing ultraviolet rays and acting as a free radical scavenger. However, when melanin is excessively produced due to external environmental changes such as overexposure to ultraviolet rays, air pollution, stress, etc., pigmentation occurs within the skin, causing darkening of the skin, dark spots, freckles, etc.

Darkening of the skin occurs due to the reaction of skin cells to internal and external factors, the representative factor being exposure to ultraviolet rays. In other words, when the skin is exposed to ultraviolet rays, tyrosinase is activated, and the tyrosinase acts on tyrosine present in skin tissue to produce DOPA and dopaquinone through an oxidation process that causes skin damage. A polymer called melanin is synthesized in melanosomes within melanocytes, which are pigment cells. This melanin is delivered to keratinocytes, which are keratin forming cells of the skin, and reaches the skin surface through the keratinization process to protect the skin from ultraviolet rays. Therefore, melanin is an essential ultraviolet ray protection agent for our human body, and also plays the role of an effective free radical scavenger that removes various radicals that modify biological components such as proteins, lipids, and nucleic acids.

In particular, protein oxidation causes the connective tissues of the skin, such as collagen, hyaluronic acid, elastin, proteoglycan, and fibronectin, to be cut, causing a severe hyperinflammatory reaction and disrupting skin elasticity. If this becomes more severe, it can lead to mutations, cancer, and decreased immune function due to DNA mutations. Therefore, it is necessary to protect the cell membrane by scavenging free radicals generated during the body's metabolic process, ultraviolet irradiation, and inflammatory reactions, and to proliferate cells by regenerating already damaged cells through active metabolism. The skin can recover quickly and maintain healthy skin.

In aging, not only free radicals but also an enzyme called matrix metalloproteinase (MMP), an enzyme that degrades collagen, is involved. In other words, the synthesis and decomposition of extracellular matrix such as collagen is properly regulated in vivo, but as aging progresses, collagen synthesis decreases and the expression of matrix metalloproteinase (MMP), an enzyme that decomposes collagen, is promoted, thereby promoting skin Elasticity decreases and wrinkles form. Additionally, these decomposition enzymes may be activated by ultraviolet irradiation. Therefore, there is a need for the development of substances that can regulate the expression of MMPs whose activation is induced within cells or inhibit their activity.

Oxygen, along with water, is an essential substance for our lives, but once it enters our body, it changes into very active oxygen for various reasons and oxidizes blood vessel cells. Today, approximately 90% of the causes of disease are known to be caused by free radicals. The human body is composed of approximately 60 trillion cells, and the cell membrane is made of lymphatic cortex, making it easy for active oxygen to connect. When an oxidation reaction occurs, unsaturated fatty acids change into lipid peroxides. This lipid peroxide damages genes, DNA, RNA, proteins, cell membranes, and cell structures, causing cancer or various adult diseases, and ultimately causes aging. Substances that prevent cells from oxidizing by eliminating or neutralizing free radicals are called antioxidants. In general, when peroxidation occurs due to active oxygen in lipids, which are components of skin cells, the structure of the cell membrane is modified, resulting in cell permeability, fluidity, inactivation of membrane enzymes and transport proteins, cleavage of protein chains, and damage to DNA and RNA. It is known that skin cells age. For this reason, efforts to remove active oxygen continued, and as a result, many sulfur-oxidizing substances were developed. Substances known to have antioxidant properties so far include ascorbic acid, beta-carotene, dibutylhydroxytoluene (BHT), and DL-α-tocopherol. .

To date, various materials as described above have been developed to suppress skin aging caused by light, but the need for natural materials is increasing.

Korean Patent No. 10-1040507 discloses a cosmetic composition containing magnolia extract and having an anti-photoaging effect.

In addition, Korean Patent No. 10-0308178 discloses a cosmetic composition containing Yulpi extract and having an effect of improving skin wrinkles.

Additionally, Korean Patent No. 11-1176525 discloses a cosmetic composition containing bee tree extract and having a grooming effect.

The present invention is a cosmetic composition containing an extract of Acer tegmentosum and an isolated compound thereof. The cosmetic composition is a cosmetic composition that protects against ultraviolet (UV) and infrared (IR) skin aging phenomenon caused by light, which is one of the causes of skin aging. The object of the present invention is to provide a cosmetic composition that has an effect of improving skin wrinkles by effectively reducing the activity of collagen decomposing enzymes expressed by the present invention.

The above-described problem is achieved by a cosmetic composition for skin protection that contains Acer tegmentosum extract and tyrosol, an isolated compound thereof, as active ingredients and has the effect of inhibiting collagen decomposition enzymes increased by ultraviolet rays or infrared rays.

Preferably, the bee tree extract and the tyrosol may be included in a weight ratio of 1:10 to 10:1.

Also preferably, the bee tree extract and the tyrosol may be contained in an amount of 0.0001 to 20.0% by weight based on the total weight of the cosmetic composition.

Also preferably, the cosmetic is selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing agents, oils, powder foundations, emulsion foundations, wax foundations and sprays. It may be the formulation of choice.

Also preferably, the bee tree extract may be extracted with an extraction solvent selected from the group consisting of anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, and butyl acetate.

The cosmetic composition according to the present invention contains bee tree and tyrosol, an isolated compound thereof, in a specific weight ratio, and has the effect of suppressing collagen decomposition enzymes increased by ultraviolet rays or infrared rays, and improving wrinkles caused by ultraviolet rays or infrared rays. has

All technical terms used in the present invention, unless otherwise defined, have the following definitions and correspond to the meaning as generally understood by a person skilled in the art in the relevant field of the present invention. In addition, preferred methods and samples are described in this specification, but similar or equivalent methods are also included in the scope of the present invention.

The term “about” refers to a quantity, level, value, number, frequency, percent, dimension, size, amount, weight or length of 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, means a quantity, level, value, number, frequency, percentage, dimension, size, volume, weight or length that varies by 4, 3, 2 or 1%.

Throughout this specification, unless the context otherwise requires, the words "comprise" and "comprising" include a given step or component, or group of steps or components, but any other step or component, or It should be understood that this implies that no step or group of components is excluded.

The present invention relates to a cosmetic composition containing Acer tegmentosum extract and tyrosol, an isolated compound thereof, as active ingredients.

The bee tree (Acer tegmentosum) used in the present invention is a deciduous tree of the maple family of the dicotyledonous plant Acer tegmentosum. The tree has smooth bark, green small branches, and grows deep in the mountains. The wood of the bee tree is hard and is often used as furniture material.

The Acer tegmentosum extract of the present invention can be prepared according to conventional methods known in the art, that is, under conventional conditions of temperature and pressure, using conventional solvents, but is preferably prepared using (a) water. , anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms (e.g., methanol, ethanol, propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butylacetate, It can be extracted using a solvent extraction method using a solvent selected from the group consisting of dichloromethane, chloroform, hexane, and mixtures thereof (b) a supercritical extraction method using reduced pressure and high temperature using carbon dioxide, or (c) an ultrasonic extraction method.

In the present invention, a solvent extraction method using an extraction solvent was preferably used. In the present invention , the Acer tegmentosum extract is extracted with various extraction solvents, such as water, anhydrous or hydrous lower alcohols having 1-4 carbon atoms (e.g., methanol, ethanol, propanol and butanol), propylene glycol, 1,3 -It can be obtained using one or more extraction solvents selected from the group consisting of butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane, and mixtures thereof, preferably It is obtained using ethanol, 70% (v/v) ethanol or water, and most preferably is obtained using 70% (v/v) ethanol.

Meanwhile, it is obvious to those skilled in the art that the Acer tegmentosum extract of the present invention can be obtained using not only the above-described extraction solvent but also other extraction solvents, showing substantially the same effect. In addition, the Acer tegmentosum extract of the present invention includes not only extracts using the above-described extraction solvent, but also extracts that have undergone conventional purification and fermentation processes. For example, decompression with carbon dioxide, extraction by supercritical extraction at high temperature, extraction by ultrasonic extraction, separation using an ultrafiltration membrane with a certain molecular weight cut-off value, and various chromatographies (size, charge, hydrophobicity or affinity). Active fractions obtained through various additional purification and extraction methods, such as separation by (designed for separation according to gender) or extracts from fermentation products in the natural state or using various microorganisms, are also included in the extract of the present invention.

The Acer tegmentosum extract according to the present invention also includes an extract that has undergone a fermentation process, and the fermented extract can be prepared as follows. Acer tegmentosum whole plant is finely crushed to a size of 100-500 mesh, then 1-50 g/L of a typical microbial culture medium is added, and microorganisms such as yeast strains or lactic acid bacteria are added in an amount of 10,000-100,000 cfu/L. The culture temperature is 30-37°C under typical microbial culture conditions. The pH is 5 to 7 and cultured under aerobic or normally anaerobic conditions for about 5 to 10 days. It can be obtained through subsequent maturation and filtration.

According to the present invention, the Acer tegmentosum extract and tyrosol, its isolated compound, are contained from 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition, and more preferably, the Acer tegmentosum extract and tyrosol are contained. It is characterized in that it is contained in an amount of 0.01 to 10% by weight based on the total weight of the cosmetic composition. If the content of the extract is less than 0.001% by weight, no skin improvement effect is observed, and if it exceeds 30.0% by weight, there are problems with the safety and stability of the formulation and it is not economical.

In the present invention, tyrosol, a compound isolated from bee tree extract, is shown in Chemical Formula 1 below.

[Formula 1]

Additionally, the bee tree extract and the tyrosol may be included in a weight ratio of 1:100 to 100:1, and more preferably, may be included in a weight ratio of 1:10 to 10:1.

The ingredients included in the cosmetic composition of the present invention are active ingredients and may include ingredients commonly used in cosmetic compositions in addition to the above-mentioned active ingredients, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances. Includes adjuvants and carriers. The cosmetic composition of the present invention can be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing products. , oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray, etc., but is not limited thereto. More specifically, it can be manufactured in the form of softening lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, or powder.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide are used as carrier ingredients. It can be.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent, or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, the carrier ingredients include water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, and microcrystals. Cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier ingredient. In particular, when the formulation is a spray, chlorofluorohydrocarbon and propane may be used as carrier ingredients. /May contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a surfactant-containing cleansing agent, the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid amide ether. Sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it can be applied to the skin and then wiped off, removed, or washed with water. As a specific example, the soap is liquid soap, powdered soap, solid soap, and oil soap, the surfactant-containing cleansing formulation is cleansing foam, cleansing water, cleansing towel, and cleansing pack, and the surfactant-free cleansing formulation is cleansing cream. , cleansing lotion, cleansing water, and cleansing gel, but are not limited thereto.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples according to the gist of the present invention.

Preparation Example 1 - Preparation of Acer tegmentosum extract

Wash the bee tree seedlings with clean water, dry them, cut them to a certain size, extract them under reflux three times for 5 hours each with 0 to 70% (V/V) ethanol aqueous solution, cool them, and filter them with Whatman #4 filter paper to obtain a concentrate. got it

Preparation Example 2 - Preparation of tyrosol

1.0 kg of the bee tree extract obtained through Preparation Example 1 was dispersed in 10 L of 1% ethanol, then non-polar components were removed using 10 L of hexane (repeated 3 times), and then equally fractionated with methylene chloride and ethyl acetate. The methylene chloride fraction layer was concentrated under reduced pressure to obtain 381 g of fraction. The active ingredients were separated using a silica gel (60 ~ 120 mesh) column, and the CH2Cl2-EtOAc mixture was used as a mobile phase to separate and purify. A total of 8 fractions were recovered, and 30.18 g was recovered from one fraction that had an excellent inhibitory effect on collagenase by UVA, UVB, and IR, and was confirmed to be tyrosol through comparison with the standard product. .

Experimental Example 1 - MMP-1 production inhibition effect

In this Experimental Example 1, the amount of MMP-1 increased by UVA, UVB, and IR was tested to determine whether the bee tree extract obtained in Preparation Example 1 was effective in inhibiting the production of MMP-1, a collagen degrading enzyme. The effect of inhibiting production was measured. Fibroblasts, which are human normal skin cells (Korean Cell Line Bank, Korea), were inoculated into 48-well microplates (Nunc, Denmark) at 1 × 10 ⁶ cells per well, and incubated in DMEM medium (Sigma, USA) and 37°C. After culturing for 24 hours, the culture was further cultured for 48 hours in serum-free DMEM medium to which Preparation Example 1 and Preparation Example 2 were added at a certain concentration and, as a control, in serum-free DMEM medium without P. chinensis extract. After incubation, the supernatant from each well was collected, the amount of newly synthesized MMP-1 (ng/ml) was measured using an MMP-1 assay kit (Amersham, USA), and the MMP-1 production inhibition rate (%) was calculated. and the results are shown in Tables 1 to 4.

Sample name Treatment concentration (ppm) MMP-1 production amount (%) Manufacturing Example 1 UV
100mJ/ ^cm2 0 100 One 93.37 ± 3.83 10 90.88 ± 1.14 Production example 2 One 94.07 ± 2.19 10 89.74 ± 9.45 100 70.17 ± 7.97

Sample name Sample name Treatment concentration (ppm) MMP-1 production amount (%) Manufacturing Example 1
10ppm Untreated UV
100mJ/ ^cm2 0 90.81 ± 1.78 Production example 2 One 83.74 ± 2.51 5 77.59 ± 3.19

Sample name Treatment concentration (ppm) MMP-1 production amount (%) Manufacturing Example 1 IR
Treated
15min 0 100 One 96.19 ± 2.04 10 88.04 ± 3.11 Production example 2 One 92.54 ± 2.97 10 84.19 ± 2.26 100 76.73 ± 2.77

Sample name Sample name Treatment concentration (ppm) MMP-1 production amount (%) Manufacturing Example 1
1 ppm Untreated IR
Treated
15min 0 97.07 ± 1.82 Production example 2 One 84.48 ± 2.39 5 80.26 ± 3.04 10 71.12 ± 1.97

Through the above experimental example, the effect of Preparation Examples 1 and 2 on inhibiting MMP-1 production was confirmed. In particular, when Preparation Example 1 and Preparation Example 2 were mixed at a specific mixing ratio, the amount of MMP-1 increased by UV and IR was confirmed. The effect of suppressing production can be confirmed.

Prescription Example 1 - Toner

Preparation examples of lotions among cosmetics containing a mixture of Preparation Example 1 and Preparation Example 2 are shown in Table 5 below.

Formulation example 1 Formulation example 2 Formulation example 3 Formulation example 4 content
(Unit: weight%) Mixed extract (Preparation Example 1: Preparation Example 2 = 10:1 (weight ratio)) Mixed extract (Preparation Example 1: Preparation Example 2 = 5:1 (weight ratio)) Mixed extract (Preparation Example 1: Preparation Example 2 = 1:5 (weight ratio)) Mixed extract (Preparation Example 1: Preparation Example 2 = 1:10 (weight ratio)) 3.0 glycerin glycerin glycerin glycerin 5.0 1.3-Butylene glycol 1.3-Butylene glycol 1.3-Butylene glycol 1.3-Butylene glycol 3.0 PEG 1500 PEG 1500 PEG 1500 PEG 1500 1.0 allantoin allantoin allantoin allantoin 0.1 DL-panthenol DL-panthenol DL-panthenol DL-Panthenol 0.3 EDTA-2Na EDTA-2Na EDTA-2Na EDTA-2Na 0.02 Benzophenone-9 Benzophenone-9 Benzophenone-9 Benzophenone-9 0.04 Sodium Hyaluronate Sodium Hyaluronate Sodium Hyaluronate Sodium Hyaluronate 5.0
ethanol ethanol ethanol ethanol 10.0 Octicdodeses-16 Octicdodeses-16 Octicdodeses-16 Octicdodeses-16 0.2 Polysorbate 20 Polysorbate 20 Polysorbate 20 Polysorbate 20 0.2 Preservatives, fragrance, coloring Preservatives, fragrance, coloring Preservatives, fragrance, coloring Preservatives, fragrance, coloring a very small amount Distilled water Distilled water Distilled water Distilled water remaining amount Sum 100

Prescription Example 2 - Essence

Preparation examples of essence among cosmetics containing a mixture of Preparation Example 1 and Preparation Example 2 are shown in Table 6 below.

Formulation example 5 Formulation example 6 Formulation example 7 Formulation example 8 content
(Unit: weight%) mixed extract
(Manufacturing Example 1: Manufacturing Example 2 = 10:1 (weight ratio)) mixed extract
(Manufacturing Example 1: Manufacturing Example 2 = 5:1 (weight ratio)) mixed extract
(Manufacturing Example 1: Manufacturing Example 2 = 1:5 (weight ratio)) mixed extract
(Manufacturing Example 1: Manufacturing Example 2 = 1:10 (weight ratio)) 3.0
glycerin glycerin glycerin glycerin 10.0 Betaine Betaine Betaine Betaine 5.0 PEG 1500 PEG 1500 PEG 1500 PEG 1500 2.0 allantoin allantoin allantoin allantoin 0.1 DL-panthenol DL-panthenol DL-panthenol DL-Panthenol 0.3 E.D.T.A-2Na E.D.T.A-2Na E.D.T.A-2Na E.D.T.A-2Na 0.02 Benzophenone - 9 Benzophenone - 9 Benzophenone - 9 Benzophenone - 9 0.04 Hydroxyethyl Cellulose Hydroxyethyl Cellulose Hydroxyethyl Cellulose Hydroxyethyl Cellulose 0.1
Sodium Hyaluronate Sodium Hyaluronate Sodium Hyaluronate Sodium Hyaluronate 8.0 Carboxy vinyl polymer Carboxy vinyl polymer Carboxy vinyl polymer Carboxy vinyl polymer 0.2 Triethanolamine Triethanolamine Triethanolamine Triethanolamine 0.18 octyldodecanol octyldodecanol octyldodecanol octyldodecanol 0.3 Octyldodeces -16 Octyldodeces -16 Octyldodeces -16 Octyldodeces -16 0.4 ethanol ethanol ethanol ethanol 6.0 Preservatives, fragrance, coloring Preservatives, fragrance, coloring Preservatives, fragrance, coloring Preservatives, fragrance, coloring a very small amount Distilled water Distilled water Distilled water Distilled water remaining amount Sum 100

Example 1 - Skin wrinkle improvement effect of a formulation containing bee tree extract and its isolated compound

The experiment was conducted using the essence formulations of Formulation Examples 5 to 8 prepared in Preparation Example 2 and the comparative formulation examples that did not include Preparation Example 1 and Preparation Example 2. Each group selected 20 men and women in their 20s. Groups A, B, C, and D received the essence of Formulation Examples 5 and 6, and Group B received the essence of Comparative Formulation Example twice a day for 4 weeks after washing their face in the morning and evening. It was intended to be used. The effect of improving skin elasticity of each subject was evaluated by using Cutometer (C+K, Germany) to improve elasticity. The experimental results are shown in Table 7 below.

division Improvement rate compared to initial (%) 2 weeks of use After 4 weeks of use Formulation Example 5 2.15% 3.07% Formulation Example 6 2.09% 2.95% Formulation Example 7 1.87% 2.76% Formulation Example 8 2.31% 3.10% Comparative formulation example 1.24% 1.87%

When compared to the comparative example containing nothing, the formulation containing the preparation example of the present invention at a certain ratio showed an improvement rate of skin wrinkles of about 2% or more after 4 weeks compared to the initial use.

Example 2 - Irritation relieving effect of cosmetics containing mixed extracts

The experiment was conducted using the essence formulations of Formulation Examples 5 to 8 prepared in Preparation Example 2 and the comparative formulation examples that did not include Preparation Example 1 and Preparation Example 2. Each group was selected with 20 men and women in their 20s, A, Groups B, C, and D were asked to use the essence of Formulation Examples 5 to 8 containing mixed extracts, and Group E was asked to use the essence of Comparative Formulation Example twice a day for 4 weeks after washing their face in the morning and evening. The evaluation was conducted on both sides of the face to evaluate whether or not irritation appeared on the skin while using the product for 4 weeks.

division No irritation Mild irritation strong stimulation Formulation Example 5
Group A 13 7 0 Formulation Example 6 Group B 16 3 One Formulation Example 7 Group C 15 4 One Formulation Example 8 Group D 15 3 2 Comparative formulation example
Group E 10 7 3

Claims (5)

It contains as an active ingredient a mixture of Acer tegmentosum extract and its isolated compound, tyrosol, at a weight ratio of 1:10 to 10:1, and has the effect of inhibiting collagen degrading enzymes increased by ultraviolet rays or infrared rays. Cosmetic composition for skin protection. The cosmetic composition for skin protection according to claim 1, wherein the mixture of the bee tree extract and tyrosol is contained in an amount of 0.0001 to 20.0% by weight based on the total weight of the cosmetic composition. The group of claim 1, wherein the cosmetic is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing agent, oil, powder foundation, emulsion foundation, wax foundation and spray. A cosmetic composition for skin protection, characterized in that it has a formulation selected from. The cosmetic composition for skin protection according to claim 1, wherein the bee tree extract is extracted with an extraction solvent selected from the group consisting of anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, and butyl acetate. delete