KR102601884B1 - Serum distribution apparatus and serum distribution kit including the same - Google Patents

Abstract

The serum dispensing device according to the disclosed embodiment includes an inlet having an inlet through which serum flows; A plurality of container connection parts configured to be coupled to and detachable from a plurality of containers; a plurality of distribution passage portions disposed to correspond to the plurality of container connectors and each having a distribution hole to allow the serum to flow out into the container coupled to the corresponding container connector; and a plurality of recovery passage portions disposed to correspond to the plurality of container connection portions and each having a recovery hole through which the serum flows into the container coupled to the corresponding container connection portion.

Description

Serum distribution device and serum distribution kit including the same {SERUM DISTRIBUTION APPARATUS AND SERUM DISTRIBUTION KIT INCLUDING THE SAME}

The present disclosure relates to serum dispensing devices and serum dispensing kits.

There are cases where serum isolated from a patient's blood is used as a medicinal solution for treatment purposes. For example, eye hospitals prescribe serum as an eye drop to patients seeking to treat corneal diseases (e.g., dry eye syndrome, etc.) or patients who have undergone LASIK or LASEK surgery, and use it as an autologous serum eye drop ( It is called Autologous serum eye drop.

When using a regular eye drop bottle to use serum as a medicinal solution, it is not advisable as there is a high risk that the serum may be contaminated or the patient may be infected depending on the dispensing environment of the hospital or the patient's usage environment. To solve the problem of serum contamination, a system is required to block serum from the outside in the preparation and use environment. In addition, there is a risk of contamination of the serum when the container containing the serum is opened and closed multiple times and the serum is used multiple times. Therefore, it is known that the serum is distributed in small quantities into multiple small containers and the serum in one container is used once. .

Conventionally, a technique was known to create multiple containers containing serum by injecting serum into a tube in which multiple containers are connected in series and then sealing the tube by cutting a portion of the tube between two adjacent containers with a heat cutter. there is. The heating cutter heats a part of the tube while pressurizing it from the outside, so that the part of the tube is deformed to a state where the internal flow path is blocked and cut at the same time. The part of the tube cut with the internal flow path blocked becomes hardened, and the two containers sandwiching the part of the tube are separated from each other while remaining sealed.

Embodiments of the present disclosure provide devices and methods that can significantly reduce the possibility of contamination of serum and infection of patients in a preparation environment and use environment for using serum as a medicinal solution.

In the prior art, there is a problem that the process of cutting the tube using a heating cutter causes inconvenience in the work and a part of the serum may be unnecessarily heated. Embodiments of the present disclosure solve these problems of the prior art.

One aspect of the present disclosure provides embodiments of a serum dispensing device. A serum dispensing device according to a representative embodiment includes an inlet having an inlet through which serum flows; A plurality of container connection parts configured to be coupled to and detachable from a plurality of containers; a plurality of distribution passage portions disposed to correspond to the plurality of container connectors and each having a distribution hole to allow the serum to flow out into the container coupled to the corresponding container connector; and a plurality of recovery passage portions disposed to correspond to the plurality of container connection portions and each having a recovery hole through which the serum flows into the container coupled to the corresponding container connection portion. The serum distribution device forms a starting flow path connecting the inlet to the distribution hole of any one of the plurality of distribution passage parts. The serum distribution device forms a connection passage connecting the recovery hole of any one of the plurality of recovery passage parts and the distribution hole of any one of the plurality of distribution passage parts.

Another aspect of the present disclosure provides embodiments of a serum distribution kit. A serum distribution kit according to a representative embodiment includes a plurality of containers configured to accommodate serum; and a serum dispensing device configured to distribute the serum to the plurality of containers. The serum distribution device includes an inlet having an inlet through which the serum flows; A plurality of container connection parts configured to be coupled to and detachable from the plurality of containers; a plurality of distribution passage portions disposed to correspond to the plurality of container connectors and each having a distribution hole to allow the serum to flow out into the container coupled to the corresponding container connector; and a plurality of recovery passage portions disposed to correspond to the plurality of container connection portions and each having a recovery hole through which the serum flows into the container coupled to the corresponding container connection portion. The serum distribution kit forms a starting flow path connecting the inlet to the distribution hole of any one of the plurality of distribution passage parts. The serum distribution kit forms a connection passage connecting the recovery hole of any one of the plurality of recovery passage parts and the distribution hole of any one of the plurality of distribution passage parts.

According to embodiments of the present disclosure, it is possible to conveniently maintain a sealed state between serum and the outside in a preparation environment and use environment for using serum as a medicinal solution.

According to embodiments of the present disclosure, the convenience of distributing serum in small quantities to a plurality of containers can be significantly improved.

According to embodiments of the present disclosure, serum can be distributed into a plurality of containers and the plurality of containers can be separated from each other without using a heat cutter.

1 is a diagram showing an elevation or cross-section of each device of a serum distribution kit according to an embodiment of the present disclosure.
Figure 2 is an elevation view of a stopper according to an embodiment of the present disclosure.
Figure 3 is an elevation view of a blood collection device and a centrifugal balance device according to an embodiment of the present disclosure.
Figure 4 is a perspective view of a sterilization filter according to an embodiment of the present disclosure.
Figure 5 is a perspective view showing a combined state of a serum distribution device and a plurality of containers according to an embodiment of the present disclosure.
Figure 6 is a perspective view showing the appearance of Figure 5 from a different angle.
Figure 7 is a perspective view showing a separated state of a plurality of containers and a serum distribution device according to an embodiment of the present disclosure.
Figure 8 is an exploded perspective view of the plurality of containers and serum dispensing device shown in Figure 7.
Figure 9 is a cross-sectional view cut so that the internal flow path is visible when the serum distribution device and the plurality of containers of Figure 1 and the stopper of Figure 2 are combined with each other.
FIG. 10 is an enlarged cross-sectional perspective view of a portion where the serum dispensing device and container of FIG. 9 are coupled to each other.
FIG. 11 is a cross-sectional view showing the flow of serum and air where the serum dispensing device and container of FIG. 9 are combined.
FIG. 12 is a cross-sectional view showing the flow of serum after the container in FIG. 11 is filled with serum.
Figure 13 is a diagram sequentially showing the blood collection process according to one embodiment.
Figure 14 is a diagram sequentially showing the process of centrifuging serum from blood according to one embodiment.
Figure 15 is a diagram showing the process of separating and diluting serum from blood clots according to one embodiment.
Figure 16 is a diagram showing a blood chamber containing serum connected to a serum distribution device according to one embodiment.
FIG. 17 is a diagram showing a pressurizing device mounted on the blood chamber in FIG. 16 and a plurality of containers connected to the serum dispensing device.
FIG. 18 is a diagram showing a state in which serum is distributed to a plurality of containers when stoppers are placed in a plurality of containers and an end cap is coupled to a dispensing body in a serum dispensing device, according to an embodiment.
Figure 19 is a perspective view showing a combined state of a serum distribution device and a plurality of containers according to another embodiment of the present disclosure.
Figure 20 is a perspective view showing a combined state of a serum distribution device and a plurality of containers according to another embodiment of the present disclosure.

Embodiments of the present disclosure are illustrated for the purpose of explaining the technical idea of the present disclosure. The scope of rights according to the present disclosure is not limited to the embodiments presented below or the specific description of these embodiments.

All technical terms and scientific terms used in this disclosure, unless otherwise defined, have meanings commonly understood by those skilled in the art to which this disclosure pertains. All terms used in this disclosure are selected for the purpose of more clearly explaining this disclosure and are not selected to limit the scope of rights according to this disclosure.

Expressions such as “comprising,” “comprising,” “having,” and the like used in the present disclosure are open terms that imply the possibility of including other embodiments, unless otherwise stated in the phrase or sentence containing the expression. It should be understood as (open-ended terms).

The singular forms described in this disclosure may include plural forms unless otherwise stated, and this also applies to the singular forms recited in the claims.

Expressions such as “first” and “second” used in the present disclosure are used to distinguish a plurality of components from each other and do not limit the order or importance of the components.

Direction indicators such as “upward” and “up” used in the present disclosure refer to the direction of the arrow (U) shown in the attached FIGS. 5, 6 and 9, and directions such as “downward” and “down.” The indicator refers to the direction of the arrow D shown in FIGS. 5, 6, and 9. This is for explanation so that the present disclosure can be clearly understood, and each direction may be defined differently depending on where the standard is set.

Hereinafter, embodiments of the present disclosure will be described with reference to the attached drawings. In the accompanying drawings, identical or corresponding components are given the same reference numerals. Additionally, in the description of the following embodiments, overlapping descriptions of identical or corresponding components may be omitted. However, even if descriptions of components are omitted, it is not intended that such components are not included in any embodiment.

Figure 1 is a diagram showing an elevation or cross-section of each device of the serum distribution kit 1 according to an embodiment of the present disclosure.

Referring to FIG. 1, the serum distribution kit 1 includes a container 200 configured to accommodate serum. Although only one container 200 is shown in FIG. 1, the serum distribution kit 1 includes a plurality of containers 200. The serum distribution kit 1 includes a serum distribution device 100 configured to distribute serum to a plurality of containers 200.

The serum distribution device 100 may include a chamber connection body 100A configured to be coupled to and detachable from the blood chamber 510. The serum dispensing device 100 may include a dispensing body 100B in which a plurality of containers can be combined and separated. The chamber connection body 100A and the distribution body 100B may be coupled to each other. Serum dispensing device 100 may include an end cap 100C. The end cap 100C may be configured to be coupled to the distribution body 100B.

The serum distribution device 100 includes an inlet 110 having an inlet 110h through which serum flows. The serum distribution device 100 may include an outlet 120 having an outlet 120h through which air flows out. The serum dispensing device 100 includes a plurality of containers 200 and a plurality of container connection portions 130 configured to be coupled to and detachable from each other. The serum distribution device 100 includes a plurality of distribution passage portions 140 arranged to correspond to a plurality of container connection portions 130. Each of the plurality of distribution passage portions 140 has a distribution hole 140h so that serum flows out into the container 200 coupled to the corresponding container connection portion 130. The serum distribution device 100 includes a plurality of recovery passage parts 150 arranged to correspond to a plurality of container connection parts 130. Each of the plurality of recovery passage portions 150 has a recovery hole 150h through which serum flows into the container 200 coupled to the corresponding container connection portion 130.

The end cap 100C may be configured to be coupled to the outlet portion 120. The end cap 100C may be configured to allow air to pass through, but not allow serum to pass through. The end cap 100C may have a vent hole through which air is discharged to the outside. The end cap 100C may include a hydrophobic filter disposed at a position upstream of the vent hole. Air discharged through the outlet 120h of the outlet 120 may pass through the hydrophobic filter of the end cap 100C and be discharged to the outside through the vent hole. The serum flowing out through the outlet 120h of the outlet 120 does not pass through the hydrophobic filter of the end cap 100C and is not discharged to the outside.

Figure 2 is an elevation view of the stopper 300 according to an embodiment of the present disclosure.

Referring to FIG. 2, the serum distribution kit 1 may further include a stopper 300 that can be placed in a plurality of containers 200. The stopper 300 can prevent the serum containing space in the container 200 from exceeding a predetermined volume. The stopper 300 may include a limit portion 310 that contacts the bottom of the plunger of the container 200. The stopper 300 may include a plurality of limit parts 310 corresponding to the plurality of containers 200. The stopper 300 may include a base 330 that supports a plurality of limit parts 310. The plurality of limit parts 310 may protrude upward from the base 330. The plurality of limit parts 310 may be formed in a column shape.

Figure 3 is an elevation view of a blood collection device 400 and a centrifugal balance device 500 according to an embodiment of the present disclosure.

Referring to FIG. 3, the serum distribution kit 1 may further include a centrifugal balance device 500 configured to separate serum from collected blood. The centrifugal balance device 500 may include a blood chamber 510 that accommodates the collected blood. The centrifugal balance device 500 may include a centrifugal separation chamber 530 that is configured to be coupled to and detachable from the blood chamber 510.

The blood chamber 510 forms a blood receiving space therein. The blood chamber 510 may be configured to be coupled to and detachable from the inlet 110 of the serum distribution device 100. The blood chamber 510 may have an injection unit 511 configured to connect the blood receiving space with the inlet 110h of the inlet 110 when coupled to the inlet 110 . The injection unit 511 may be configured to close the blood receiving space when separated from the inlet 110.

The blood chamber 510 may include a blood casing 513 in which the blood receiving space is formed. The blood chamber 510 may include a blood piston 515 that is slidably disposed on the inner surface of the blood casing 513. The blood piston 515 may partition the blood receiving space together with the inner surface of the blood casing 513.

The centrifugal separation chamber 530 may form a centrifugal separation space therein. Liquid can be accommodated in the centrifugal separation space. The centrifugal separation chamber 530 may include a centrifugal separation inlet 531 connected to the injection portion 511 of the blood chamber 510 while being coupled to the blood chamber 510 . The centrifugation chamber 530 has a coupling guide 532 that guides the coupling position of the centrifugation chamber 530 with respect to the blood chamber 510 so that the injection unit 511 and the centrifugation inlet 531 are connected to each other. ) may include. The outer circumferential surface of the blood chamber 510 is guided to the inner circumferential surface of the coupling guide 532 and can be inserted.

The centrifugal separation chamber 530 may include a centrifugal separation casing 533 in which the centrifugal separation accommodation space is formed. The centrifugal separation chamber 530 may include a centrifugal separation piston 535 that is slidably disposed on the inner surface of the centrifugal separation casing 533. The centrifugal separation piston 535 may partition the centrifugal separation accommodation space together with the inner surface of the centrifugal separation casing 533.

When coupled to the centrifugation chamber 530, the injection unit 511 of the blood chamber 510 may connect the blood receiving space and the centrifugation space. The injection unit 511 may be configured to close the blood receiving space when separated from the centrifugation chamber 530. The injection unit 511 may include a pressure valve (not shown) having a hole that opens when pressed from the outside. When the blood chamber 510 and the centrifugation chamber 530 are coupled to each other, the blood receiving space and the centrifugation space may be connected to each other through the injection unit 511 and the centrifugation inlet 531.

The centrifugal balance device 500 may include a piston rod 550 that is configured to be coupled to and detachable from the blood chamber 510. The piston rod 550 may be configured to be coupled to and detachable from the blood piston 515. The piston rod 550 may be configured to be coupled to and detachable from the centrifugal separation chamber 530 while being separated from the blood chamber 510. The piston rod 550 may be configured to be coupled to and detachable from the centrifugal piston 535. The piston rod 550 may include a piston coupling portion 551 configured to be coupled to the blood piston 515. The piston coupling portion 551 may be configured to be coupled to the centrifugal piston 535. For example, the piston coupling portion 551 may include a screw configured to engage with the screw formed on the blood piston 515 and the screw formed on the centrifugal piston.

The piston rod 550 may be configured to protrude out of the blood casing 513 while being coupled to the blood piston 515. The piston rod 550 may include a manipulation unit 553 that protrudes out of the blood casing 513 while being coupled to the blood piston 515 . A piston coupling portion 551 may be formed at one end of the piston rod 550, and an operating portion 553 may be formed at the other end of the piston rod 550.

The serum distribution kit 1 may include a blood collection device 400 configured to collect blood from a patient. Both ends 410 and 420 of the blood collection device 400 may be configured to be connectable to the injection portion 511 of the blood chamber 510 and the patient, respectively. One end 410 of the blood collection device 400 may be formed with a screw that can be coupled to the injection unit 511. The other end 420 of the blood collection device 400 may be inserted into the patient's skin to form a hole through which blood flows. The blood collection device 400 may be configured to guide the movement of blood from the patient into the blood receiving space of the blood chamber 510.

Figure 4 is a perspective view of a sterilization filter according to an embodiment of the present disclosure.

Referring to FIG. 4, the serum distribution kit 1 may further include a sterilization filter 600 that can be coupled to the inlet 210h of the container 200. The sterilization filter 600 may include a filter coupling portion 610 that forms a screw that can be coupled to the inlet 210h of the container 200. The sterilization filter 600 can use various products with a sterilization function. The sterilization filter 600, when combined with the container 200, may serve to prevent bacteria from invading the serum in the container 200 from the outside.

Figure 5 is a perspective view showing a combined state of a plurality of containers and a serum distribution device according to an embodiment of the present disclosure. Figure 6 is a perspective view showing the appearance of Figure 5 from a different angle. Figure 7 is a perspective view showing a separated state of a plurality of containers and a serum distribution device according to an embodiment of the present disclosure. In the drawing, the number of containers 200 is shown as 5, but this is only an example, and the number of containers 200 and the number of container connection parts 130 corresponding thereto are not limited thereto.

Referring to FIGS. 5 to 7 , a plurality of containers 200 may be separably coupled to the serum dispensing device 100. The plurality of container connection parts 130 of the serum distribution device 100 may be configured so that the plurality of containers 200 can be coupled to the plurality of container connection parts 130 at the upper side (U). A plurality of container connection parts 130 may be arranged in parallel. In a state where the plurality of containers 200 and the serum distribution device 100 are coupled to each other, the inlets of the plurality of containers 200 may be disposed facing the upper side (U). Serum entering the serum receiving space in the container 200 through the distribution hole 140h of the distribution passage 140 fills up from the bottom of the serum receiving space, and enters the recovery hole 150h of the recovery passage 150. Air within the serum receiving space may escape through the space.

The distribution body 100B of the serum distribution device 100 may include a body coupling portion 101 configured to be coupled to the chamber connection body 100A. A screw that engages with the screw of the chamber connection body 100A may be formed in the body coupling portion 101. A hole connected to a starting passage (Ps), which will be described later, may be formed in the center of the body coupling portion 101. In a state where the chamber connection body 100A and the distribution body 100B are coupled, serum may flow into the inside of the distribution body 100B from the inside of the chamber connection body 100A through the hole of the body coupling portion 101. You can.

A plurality of container connection parts 130 may be formed to protrude from the lower side (D) of the serum distribution device 100. A plurality of container connection parts 130 may be formed to be spaced apart from each other in a direction perpendicular to the vertical direction. The outlet portion 120 may be formed to protrude toward the upper side (U) of the serum distribution device 100. The body coupling portion 101 may be formed to protrude toward the upper side (U) of the distribution body (100B).

Figure 8 is an exploded perspective view of the plurality of containers and serum dispensing device shown in Figure 7.

Referring to FIG. 8, the distribution body 100B may include a first part 100B1 and a second part 100B2 that are coupled to each other. The first part 100B1 and the second part 100B2 may be combined to form a portion of the flow path of the serum distribution device 100 between the first part 100B1 and the second part 100B2. A plurality of container connection parts 130 may be formed in the first part 100B1. The outlet portion 120 and the body coupling portion 101 may be formed in the second part 100B2.

Figure 9 is a cross-sectional view cut so that the internal flow path is visible when the serum distribution device and the plurality of containers of Figure 1 and the stopper of Figure 2 are combined with each other. FIG. 10 is an enlarged cross-sectional perspective view of a portion where the serum dispensing device and container of FIG. 9 are coupled to each other.

Referring to FIGS. 8 to 10 , the plurality of containers 200 may each include a container casing 210 and a plunger 230. A serum receiving space (200s) is formed inside the container casing (210). An inlet 210h of the container 200 is formed at the top of the container casing 210. The inlet 210h is connected to the serum receiving space 200s. The distribution passage portion 140 of the serum distribution device 100 may be inserted into the container 200 through the inlet 210h of the container. The recovery passage portion 150 of the serum distribution device 100 may be inserted into the container 200 through the inlet 210h of the container. The container casing 210 may include a container coupling portion 211 configured to be coupled to the container connecting portion 130 of the serum dispensing device 100. A hole into which the limit portion 310 of the stopper 300 is inserted may be formed at the bottom of the container casing 210.

The plunger 230 may be slidably disposed on the inner surface of the container casing 210. The plunger 230 may partition the serum receiving space 200s together with the inner surface of the container casing 210. The plunger 230 may change the volume of the serum receiving space 200s by sliding with respect to the container casing 210. The plunger 230 may be placed at a preset position with respect to the container casing 210 so as to have a predetermined volume of the serum receiving space 200s before the serum is accommodated in the serum receiving space 200s. The stopper 300 can contact the plunger 230 to prevent the plunger 230 from sliding in the direction D that expands the serum receiving space 200s beyond the preset position with respect to the container casing 210. It can be configured as follows.

Referring to FIG. 9, the serum distribution device 100 forms a flow path that guides the flow of serum. The flow path of the serum distribution device 100 may guide the flow of air and serum. The flow path of the serum distribution device 100 may include a starting flow path (Ps). One starting flow path (Ps) may be provided. The flow path of the serum distribution device 100 may include a connection flow path (Pc). A plurality of connection passages (Pc) may be provided. The flow path of the serum dispensing device 100 may include an ending flow path (Pe). One ending flow path (Pe) may be provided.

The starting passage Ps connects the inlet 100h to any one distribution hole 140h of the plurality of distribution passage parts 140. The starting flow path (Ps) may guide the flow of serum from the inlet (100h) to the serum receiving space (200s) of any one of the plurality of containers (200).

The connection passage Pc connects the recovery hole 150h of any one of the plurality of recovery passage parts 150 and the distribution hole 140h of any one of the plurality of distribution passage parts 140. The connection passage Pc may guide the flow of serum from the serum receiving space 200s of one container 200 to the serum receiving space 200s of the other container 200. For example, one connection passage (Pc) guides the flow of serum from the serum receiving space (200s) of one of the containers (200) to the serum receiving space (200s) of the other container (200). Can be, and the other connection passage (Pc) guides the flow of serum from the serum receiving space (200s) of the other container (200) to the serum receiving space (200s) of the other container (200). You can.

The ending flow path Pe connects the recovery hole 150h and the outlet 120h of any one of the plurality of recovery passage parts 150. The ending passage (Pe) can guide the flow of serum from the serum receiving space (200s) of one container (200) to the outlet (120h).

The serum distribution device 100 is configured to allow serum to sequentially flow along the starting flow path (Ps) and the connecting flow path (Pc) with the plurality of containers 200 coupled to the plurality of container connection portions 130. You can. The starting flow path (Ps) and the connecting flow path (Pc) may be connected in series by the serum receiving space (200s). Two connection channels (Pc) can be connected in series by the serum receiving space (200s).

The serum distribution device 100 is configured to allow air to sequentially flow along the connection flow path (Pc) and the ending flow path (Pe) while the plurality of containers 200 are coupled to the plurality of container connection parts 130. You can. Any one connection flow path (Pc) and the ending flow path (Pe) may be connected in series by the serum receiving space (200s).

In the serum distribution device 100, with a plurality of containers 200 coupled to a plurality of container connection parts 130, air sequentially flows through the starting flow path (Ps), the connecting flow path (Pc), and the ending flow path (Pe). It can be configured to flow along. One starting flow path (Ps), a plurality of connecting flow paths (Pc), and one ending flow path (Pe) may be sequentially connected in series.

8 to 10, the distribution passage portion 140 and the recovery passage portion 150 each form a passage constituting a portion of the flow path of the serum distribution device 100. In this embodiment, the distribution passage portion 140 is shown as having the shape of a needle, but the distribution passage portion 140 may be formed in various other shapes forming a passage. Additionally, in this embodiment, the recovery passage portion 150 is shown as having the shape of a needle, but the recovery passage portion 150 may be formed in various other shapes forming a passage. Hereinafter, the distribution passage portion 140 and the recovery passage portion 150 will be described based on the needle shape, but the present disclosure is not limited thereto.

The distribution passage portion 140 may include a dispensing needle 140 fixed to the container connection portion 130. Dispensing needle 140 may be fixed to the central portion of the container connection portion 130. The dispensing needle 140 may protrude downward from the container connection portion 130. A distribution hole 140h may be formed at the protruding end of the distribution needle 140. The dispensing needle 140 may be configured so that the protruding end of the dispensing needle 140 can be retracted into the container 200. With the container 200 coupled to the container connection portion 130, the protruding end of the dispensing needle 140 may be retracted into the container 200.

The recovery passage portion 150 may include a recovery needle 150 fixed to the container connection portion 130 to which the distribution needle 140 is fixed. The recovery passage portion 150 may be fixed to the central portion of the container connection portion 130. The recovery needle 150 may protrude downward from the container connection portion 130. A recovery hole 150h may be formed at the protruding end of the recovery needle 150. The recovery needle 150 may be configured so that the protruding end of the recovery needle 150 can be retracted into the container 200. With the container 200 coupled to the container connection portion 130, the protruding end of the recovery needle 150 may be retracted into the container 200.

The description is as follows based on the distribution needle 140 and the recovery needle 150 disposed in one container connection part 130. Dispensing needle 140 and recovery needle 150 may be arranged in parallel. Dispensing needle 140 may be longer than recovery needle 150. Dispensing needle 140 may protrude longer than recovery needle 150. The protruding end of the recovery needle 150 may be located above the protruding end of the dispensing needle 140. Accordingly, while the container 200 is coupled upward to the serum distribution device 100, the serum entering the serum receiving space 200s in the container 200 through the distribution hole 140h of the distribution needle 140 is serum. When the receiving space (200s) fills up from the bottom, the level of serum in which the recovery hole (150h) of the recovery needle 150 is submerged in serum can be increased, and the recovery hole (150h) is submerged in serum. Until then, the air in the serum receiving space (200s) can escape smoothly through the recovery hole (150h).

The plunger 230 of the container 200 may be located lower than the protruding end of the dispensing needle 140 when the container 200 is coupled upward to the container connection portion 130. Accordingly, it is possible to prevent the dispensing needle 140 from being interfered with by the plunger 230.

The serum dispensing device 100 may include a partition wall 160 disposed between the dispensing needle 140 and the recovery needle 150. A plurality of partition walls 160 may be provided to correspond to the plurality of distribution needles 140 and the plurality of recovery needles 150. The partition wall 160 may separate the flow path to which the distribution needle 140 is connected and the flow path to which the recovery needle 150 is connected. For example, in the portion shown in FIG. 10, the partition wall 160 separates the starting passage Ps to which the distribution needle 140 is connected and the connection passage Pc to which the recovery needle 150 is connected. The partition 160 may be disposed between the fixed distal end 141 of the dispensing needle 140 and the fixed distal end 151 of the retrieval needle 150. The fixed end 141 of the dispensing needle 140 is fixed to the container connection 130. The fixed end portion 151 of the recovery needle 150 is fixed to the container connection portion 130.

The serum dispensing device 100 may include a dispensing needle sealer 170 disposed around the fixed distal end 141 of the dispensing needle 140. The dispensing needle sealer 170 can prevent serum from leaking along the outer peripheral surface of the dispensing needle 140 from the flow path connected to the dispensing needle 140.

The serum dispensing device 100 may include a retrieval needle sealer 180 disposed around the fixed distal end 151 of the retrieval needle 150 . The recovery needle sealer 180 can prevent serum from leaking along the outer peripheral surface of the recovery needle 150 from the passage connected to the recovery needle 150.

A partition wall 160 may be disposed between the dispensing needle sealer 170 and the recovery needle sealer 180. Dispensing needle sealer 170 may include a flat surface contacting partition wall 160. Recovery needle sealer 180 may include a flat surface that contacts partition wall 160.

The inlet 110 of the serum distribution device 100 may include a blood chamber connection portion 111 configured to be coupled to and detachable from the blood chamber 510 containing the serum. An inlet 110h, which is an upstream end of the starting flow path Ps, may be formed in the blood chamber connection portion 111. When the serum distribution device 100 and the blood chamber 510 are combined, the blood chamber connection portion 111 may contact the injection portion 511 of the blood chamber 510.

The distribution body 100B may include an end cap connection portion 121 configured to be coupled to and detachable from the end cap 100C. An outlet 120h, which is the downstream end of the ending flow path Pe, may be formed in the end cap connection portion 121.

The serum distribution device 100 may further include a valve 190 configured to open and close the starting flow passage Ps. The valve 190 may be disposed on the chamber connection body 100A. The valve 190 may be configured to change the opening and closing of the starting flow path (Ps) according to rotation. For example, in Figure 9, the direction of rotation of the valve 190 is shown by an arrow.

FIG. 11 is a cross-sectional view showing the flow of serum and air where the serum dispensing device 100 and the container 200 of FIG. 9 are coupled to each other. Referring to FIG. 11, serum (S) may flow into the serum receiving space (200s) of the container 200 through the distribution hole (140h) (see arrow A1). As serum (S) flows into the serum receiving space (200s), air within the serum receiving space (200s) may flow into the connection flow path (Pc) through the recovery hole (150h) (see arrow A2).

FIG. 12 is a cross-sectional view showing the flow of serum after the container 200 in FIG. 11 is filled with serum. Referring to FIG. 12, when the serum (S) fills up to a predetermined level or higher in the serum receiving space (200s), the recovery hole (150h) is immersed in the serum (S). With the recovery hole (150h) immersed in serum (S), serum (S) continues to flow into the serum receiving space (200s) through the distribution hole (140h) (see arrow A1), and the serum (S) continues to flow into the serum receiving space (200s). The serum (S) inside flows into the connection passage (Pc) through the recovery hole (150h) (see arrow A3) and then flows into the serum receiving space of the container. The process of filling the container with serum is the same as described above with reference to FIGS. 11 and 12.

Figure 13 is a diagram sequentially showing the process of collecting blood using the serum distribution kit (1). With reference to FIG. 13, the blood collection process according to one embodiment will be described in order as follows.

Referring to (a) of FIG. 13, the blood collection device 400 and the blood chamber 510 are combined. Additionally, the piston rod 550 is coupled to the blood chamber 510.

Referring to (b) of FIG. 13, the blood collection device 400 is connected to the patient to collect the patient's blood (B). The collected blood (B) is filled in the blood receiving space in the blood casing 513 formed by pulling the piston rod 550.

Referring to (c) of FIG. 13, the blood collection device 400 is separated from the blood chamber 510. Additionally, separate the piston rod 550 from the blood chamber 510.

Referring to (d) of FIG. 13, the blood chamber 510 containing the blood (B) and the centrifugation chamber 530 are combined with each other.

Figure 14 is a diagram sequentially showing the process of centrifuging serum from blood using the serum distribution kit (1). With reference to FIG. 14, the serum centrifugation process according to one embodiment is described as follows.

Referring to (a) of FIG. 14, the blood chamber 510 containing the blood (B) and the centrifugation chamber 530 are combined to prepare for centrifugation.

Referring to (b) of FIG. 14, the blood chamber 510 and the centrifugal separation chamber 530 coupled to each other are placed in a centrifuge (not shown), and the centrifuge is operated. A portion of the blood may move into the centrifugal separation chamber 530 through the injection portion 511 of the blood chamber 510. After a predetermined period of time, the blood (B) is separated into serum (S) and blood clots (C) due to the difference in specific gravity. By centrifugal force, the centrifugal separation piston 535 slides to one side with respect to the centrifugal separation casing 533 to increase the centrifugal separation space, and the blood piston 515 slides to one side with respect to the blood casing 513 to expand the blood receiving space. This decreases. The centrifugal separation space may be filled with blood clots. The boundary between the separated serum (S) and the blood clot (C) may not coincide with the boundary between the centrifugation space and the blood receiving space.

Referring to (c) of FIG. 14, the piston rod 550 is coupled to the blood chamber 510 or the centrifugation chamber 530 to deposit serum (S) and blood clots at the border of the blood receiving space and the centrifugation space. The volume of the blood receiving space and the volume of the centrifugation space can be adjusted so that the boundaries in (C) match. In the example of Figure 14 (c), the centrifugation piston 535 is pushed by the piston rod 550, and a small amount of serum (S) introduced into the centrifugation chamber 530 according to the centrifugation operation is transferred to the blood chamber 510. ) into the inside.

Figure 15 is a diagram showing the process of separating and diluting serum from blood clots using the serum distribution kit (1). With reference to 15, the process of separating serum and blood clots and diluting serum according to one embodiment will be described in order as follows.

Referring to (a) of FIG. 15, when the serum (S) is collected into the blood chamber 510 (see (c) of FIG. 14), the blood chamber 510 is divided into the centrifugation chamber 530 where the blood clots (C) are collected. ) is separated from.

Referring to (b) of FIG. 15, the piston rod 550 is coupled to the blood chamber 510 filled with serum (S).

Referring to (c) of FIG. 15, saline solution and/or other drugs are added into the blood chamber 510 according to the prescription to dilute the serum (S) in the blood chamber 510.

In (b) and (c) of Figure 15, undiluted serum is shown as S0 and diluted serum is shown as S1. However, 'serum' referred to in other parts of the present disclosure refers to undiluted serum and diluted serum. It can be understood as an all-encompassing concept.

FIG. 16 is a diagram showing the blood chamber 510 accommodating serum (S) connected to the serum distribution device 100 according to one embodiment. Referring to FIG. 16, when the blood chamber 510 accommodating the diluted serum (S) is coupled to the serum distribution device 100, the valve 190 maintains the flow path of the serum distribution device 100 in a closed state. You can.

FIG. 17 is a diagram showing the pressurizing device 7000 mounted on the blood chamber 510 in FIG. 16 and a plurality of containers 200 coupled to the serum dispensing device 100.

The serum distribution kit 1 is a pressurizing device configured to pressurize the blood piston 515 of the blood chamber 510 while the blood chamber 510 is coupled to the inlet 110 of the serum distribution device 100 700) may further be included. The pressurizing device 700 may pressurize the blood piston 515 via the piston rod 550.

The pressurizing device 700 may include a holder portion 790 on which the blood chamber 510 is seated. The pressing device 700 may include an elastic member 710 that provides elastic force to press the blood piston 515. For example, the elastic member 710 may include a spring. One end of the elastic member 710 is caught by the holder portion 790, and the other end of the elastic member 710 can push the pressing portion 730. The pressing device 700 may include a pressing part 730 that pushes the piston rod 550. The pressing portion 730 may push the piston rod 550 by being pushed to one side (lower side) by the other end of the elastic member 710. The pressing part 730 may be configured to slide along the holder part 790. The pressing device 700 may include a lever 750 rotatably disposed on the holder portion 790. The pressing device 700 may include a lever connecting portion 770, one end of which is rotatably connected to the lever 750 and the other end of which is rotatably disposed on the pressing portion 730. When the user pulls and rotates the lever 750, the pressing portion 730 slides to the other side (upper side) and the elastic member 710 is elastically compressed. Next, when the blood chamber 510 is seated on the holder part 790, the pressing part 730 can continuously press the piston rod 550 by the restoring elastic force of the elastic member 710.

18 shows that, according to one embodiment, the stopper 300 is placed in a plurality of containers 200 and the end cap 100C is coupled to the distribution body 100B in the serum distribution device 100, and the serum (S) is This is a diagram showing the distribution state in a plurality of containers 200. Referring to FIG. 18, the flow path of the serum distribution device 100 can be opened using the valve 190, and the blood piston 515 of the blood chamber 510 can be pressurized (see arrow M1). The serum (S) in the blood chamber 510 is sequentially filled into the plurality of containers 200, and the air inside the plurality of containers 200 and the flow path is discharged to the outside through the end cap 100C. Thereafter, the plurality of containers 200 can be separated from the serum distribution device 100.

Figure 19 is a perspective view showing a combined state of a serum distribution device 100' and a plurality of containers according to another embodiment of the present disclosure. Hereinafter, with reference to FIG. 19, the serum distribution device 100' according to another embodiment will be described, focusing on the differences from the serum distribution device 100 according to one embodiment described above.

The serum distribution device 100' may be provided with a plurality of the starting flow paths. The serum distribution device 100' may be provided with a plurality of ending passages. In the serum distribution device 100', the number of starting flow paths may be equal to the number of ending flow paths. The flow path of the serum distribution device 100' may include a plurality of branch flow paths branching from each other. The plurality of branch flow paths may be branched from each other by the plurality of starting flow paths. The number of branch flow paths is equal to the number of starting flow paths. The plurality of branch flow paths may branch from each other based on the inlet 110h. Each of the plurality of branch flow paths has an outlet (120h) at its downstream end.

The serum distribution device 100' may further include a branch portion 103 configured to allow the plurality of starting passages to branch from each other. The serum distribution device 100' may further include a plurality of branch portions 105 that respectively correspond to the plurality of branch flow paths and form part of the branch flow paths. The plurality of branch portions 105 may extend in the horizontal direction. A plurality of branch parts may be arranged parallel to each other.

Each of the plurality of branch flow paths may be configured to allow serum to sequentially flow along the starting flow path and the connecting flow path while the plurality of containers 200 are coupled to the plurality of container connection parts 130. Each of the plurality of branch flow paths may be configured to allow air to sequentially flow along the connection flow path and the ending flow path while the plurality of containers 200 are coupled to the plurality of container connection parts 130. Each of the plurality of branch flow paths may be configured to allow air to sequentially flow along the starting flow path, the connecting flow path, and the ending flow path while the plurality of containers 200 are coupled to the plurality of container connection parts 130. You can. In each of the plurality of branch flow paths, one starting flow path (Ps), a plurality of connecting flow paths (Pc), and one ending flow path (Pe) may be sequentially connected in series.

Figure 20 is a perspective view showing a combined state of a serum distribution device 100'' and a plurality of containers according to another embodiment of the present disclosure. Hereinafter, with reference to FIG. 20, the serum distribution device 100'' according to another embodiment will be described, focusing on the differences from the serum distribution device 100' according to the other embodiment described above.

The plurality of branch portions 105 of the serum distribution device 100'' may be arranged radially. The plurality of branch portions 105 of the serum distribution device 100'' may be arranged along the circumferential direction with the branch portion 103 as the center.

Although the technical idea of the present disclosure has been described through some embodiments and examples shown in the accompanying drawings, it does not go beyond the technical idea and scope of the present disclosure that can be understood by a person skilled in the art to which the present disclosure pertains. It should be noted that various substitutions, modifications and changes may be made within the scope. Furthermore, such substitutions, modifications and alterations are intended to fall within the scope of the appended claims.

B: Blood, S, S0, S1: Serum, C: Blood clot, Ps: Starting flow path, Pc: Connection flow path, Pe: Ending flow path, 1: Serum distribution kit, 100: Serum distribution device, 100A: Chamber connection body, 100B : distribution body, 100C: end cap, 101: body coupling, 110: inlet, 110h: inlet, 111: blood chamber connection, 120: outlet, 120h: outlet, 121: end cap connection, 130: vessel connection, 140: dispensing passage portion, dispensing needle, 140h: dispensing hole, 141: fixed end portion of dispensing needle, 150: retrieval passage portion, retrieval needle, 150h: retrieval hole, 151: fixed distal end portion of retrieval needle, 160: partition wall, 170: Dispensing needle sealer, 180: Recovery needle sealer, 190: Valve, 200: Container, 200s: Serum receiving space, 210: Casing, 210h: Inlet of container, 211: Container coupling part, 230: Container plunger, 300: Stopper, 400 : blood collection device, 500: centrifugation balance device, 510: blood chamber, 511: injection part, 513: blood casing, 515: blood piston, 530: centrifugation chamber, 531: centrifugation inlet, 532: coupling guide, 533 : centrifugal casing, 535: centrifugal piston, 550: piston rod, 551: piston coupling, 553: operating unit, 600: sterilization filter, 700: pressurizing device, 710: elastic member, 730: pressurizing unit, 750: lever, 770: lever connection part, 790: holder part

Claims (20)

an inlet having an inlet through which serum flows;
A plurality of container connection parts configured to be coupled to and detachable from a plurality of containers;
a plurality of distribution passage portions disposed to correspond to the plurality of container connectors and each having a distribution hole to allow the serum to flow out into the container coupled to the corresponding container connector; and
A plurality of recovery passage parts disposed to correspond to the plurality of vessel connection parts and having recovery holes to allow the serum to flow from the vessel coupled to the corresponding vessel connection part,
Forming a starting flow path connecting the inlet to the distribution hole of any one of the plurality of distribution passage parts,
Forming a connection passage connecting the recovery hole of any one of the plurality of recovery passage parts and the distribution hole of any one of the plurality of distribution passage parts,
Serum dispensing device. According to paragraph 1,
Configured to allow the serum to sequentially flow along the starting flow path and the connecting flow path while the plurality of containers are coupled to the plurality of container connection parts,
Serum dispensing device. According to paragraph 1,
It further includes an outlet having an outlet through which air flows out,
Forming an ending passage connecting the recovery hole of any one of the plurality of recovery passage portions and the outlet,
Serum dispensing device. According to paragraph 3,
In a state where the plurality of containers are coupled to the plurality of container connection parts, air is configured to sequentially flow along the connection flow path and the ending flow path,
Serum dispensing device. According to paragraph 4,
Further comprising an end cap configured to be coupled to the outlet and configured to allow the air to pass through but not to allow the serum to pass through,
Serum dispensing device. According to paragraph 1,
The distribution passage portion is fixed to the container connection portion and protrudes downward, and the protruding end at which the distribution hole is formed includes a dispensing needle configured to be retractable into the container.
Serum dispensing device. According to clause 6,
The recovery passage portion includes a recovery needle that is fixed to the container connection portion to which the distribution needle is fixed and protrudes downward, and the protruding end at which the recovery hole is formed is configured to be retractable into the container,
The protruding end of the retrieval needle is located above the protruding end of the dispensing needle,
Serum dispensing device. According to clause 6,
The recovery passage portion includes a recovery needle that is fixed to the container connection portion to which the distribution needle is fixed and protrudes downward, and the protruding end at which the recovery hole is formed is configured to be retractable into the container,
Further comprising a partition disposed between the distribution needle and the recovery needle and separating the passage to which the distribution needle is connected and the passage to which the recovery needle is connected,
Serum dispensing device. According to clause 6,
The recovery passage portion includes a recovery needle that is fixed to the container connection portion to which the distribution needle is fixed and protrudes downward, and the protruding end at which the recovery hole is formed is configured to be retractable into the container,
a dispensing needle sealer disposed around a fixed end portion of the dispensing needle secured to the container connection; and
further comprising a retrieval needle sealer disposed around a fixed end portion of the retrieval needle secured to the container connection.
Serum dispensing device. According to paragraph 1,
The plurality of container connection parts are configured such that the plurality of containers can be coupled to the plurality of container connection parts upwardly,
Serum dispensing device. According to paragraph 1,
The inlet portion includes a blood chamber connection portion configured to be capable of being coupled to and separated from the blood chamber containing the serum,
Further comprising a valve configured to open and close the starting passage,
Serum dispensing device. A plurality of containers configured to accommodate serum; and
A serum dispensing device configured to distribute the serum to the plurality of containers,
The serum distribution device,
an inlet having an inlet through which the serum flows;
A plurality of container connection parts configured to be coupled to and detachable from the plurality of containers;
a plurality of distribution passage portions disposed to correspond to the plurality of container connectors and each having a distribution hole for allowing the serum to flow out into the container coupled to the corresponding container connector; and
A plurality of recovery passage parts disposed to correspond to the plurality of vessel connection parts and having recovery holes to allow the serum to flow from the vessel coupled to the corresponding vessel connection part,
Forming a starting flow path connecting the inlet to the distribution hole of any one of the plurality of distribution passage parts,
Forming a connection passage connecting the recovery hole of any one of the plurality of recovery passage parts and the distribution hole of any one of the plurality of distribution passage parts,
Serum dispensing kit. According to clause 12,
Each of the plurality of containers is,
A container casing in which a serum receiving space is formed; and
It includes a plunger that is slidably disposed on the inner side of the container casing and partitions the serum receiving space together with the inner side of the container casing,
Further comprising a stopper configured to contact the plunger to prevent the plunger from sliding in a direction that expands the serum receiving space beyond a preset position with respect to the container casing,
Serum dispensing kit. According to clause 12,
The distribution passage portion includes a dispensing needle fixed to the container connection portion and protruding downward, and the protruding end at which the dispensing hole is formed is configured to be retractable into the container,
Each of the plurality of containers is,
A container casing in which a serum receiving space is formed; and
It is slidably disposed on the inner surface of the container casing, defines the serum receiving space with the inner surface of the container casing, and when the container is coupled upward to the container connection portion, it is positioned more than the protruding end of the dispensing needle. Including a plunger located on the lower side,
Serum dispensing kit. According to clause 12,
Forming a blood receiving space therein, configured to be coupled to and detachable from the inlet, connecting the blood receiving space and the inlet when coupled to the inlet, and connecting the blood receiving space and the inlet when separated from the inlet. further comprising a blood chamber having an infusion portion configured to be closed,
Serum dispensing kit. According to clause 15,
It further includes a centrifugal separation chamber that forms a centrifugal separation space therein and is configured to be capable of being coupled to and separated from the blood chamber,
The injection unit is configured to connect the blood receiving space and the centrifuging space when coupled to the centrifuging chamber and to close the blood receiving space when separated from the centrifuging chamber.
Serum dispensing kit. According to clause 15,
The blood chamber is,
a blood casing in which the blood receiving space is formed; and
It includes a blood piston that is slidably disposed on the inner side of the blood casing and partitions the blood receiving space together with the inner side of the blood casing,
Further comprising a piston rod configured to be coupled to and detachable from the blood piston and configured to protrude out of the blood casing while coupled to the blood piston,
Serum dispensing kit. According to clause 15,
Further comprising a blood collection device, each end of which is configured to be connectable to the injection unit and the patient, and configured to guide the movement of blood from the patient into the blood receiving space,
Serum dispensing kit. According to clause 15,
The blood chamber is,
a blood casing in which the blood receiving space is formed; and
It includes a blood piston that is slidably disposed on the inner side of the blood casing and partitions the blood receiving space together with the inner side of the blood casing,
Further comprising a pressurizing device configured to pressurize the blood piston while the blood chamber is coupled to the inlet,
Serum dispensing kit. According to clause 12,
It is configured to be attachable to the inlet of the container and further includes a sterilization filter having a sterilization function,
Serum dispensing kit.

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