TW202319079A - Serum distribution apparatus and serum distribution kit including the same - Google Patents

Abstract

A serum-dispensing apparatus according to a disclosed embodiment comprises: an inflow part having an inlet in through which serum flows; a plurality of cylinder connection parts, which can be coupled to and separated from a plurality of cylinders; a plurality of dispensing passage parts, which are arranged to correspond to the plurality of cylinder connection parts, and have dispensing holes so as to allow the serum to flow out into the cylinders coupled to the respective corresponding cylinder connection parts; and a plurality of recovery passage parts, which are arranged to correspond to the plurality of cylinder connection parts, and have recovery holes so as to allow the serum to flow in from the cylinders coupled to the respective corresponding cylinder connection parts.

Description

Serum distribution device and serum distribution kit comprising the same

The present disclosure relates to serum dispensing devices and serum dispensing kits.

In some cases, serum (serum) isolated from a patient's blood is used as a medicinal solution for therapeutic purposes. For example, eye hospitals for patients who want to treat corneal diseases (such as xerophthalmia, etc.) Patients are prescribed serum as eye drops, which are called autologous serum eye drops.

When using an ordinary eye drop bottle to use serum as a liquid medicine, it is not suitable to use because the serum may be contaminated or the patient may be infected depending on the preparation environment of the hospital or the use environment of the patient. In order to solve the problem of serum contamination, it is necessary to establish a system for isolating serum from the outside world in the preparation and use environment. In addition, when the container containing the serum is opened and closed many times and the serum is used multiple times, the serum may be contaminated. Therefore, a method is known in which a small amount of serum is distributed into a plurality of small containers, and the serum in one container is used only once.

Conventionally, there is known a technique of injecting serum into a tube in the form of a plurality of containers connected in series, and then cutting and sealing a part of the tube between two adjacent containers with a heating cutter, thereby producing a serum-filled tube. container. The heated cutter pressurizes and heats a part of the tube from the outside, so that the corresponding part of the tube is deformed into a state where the internal flow path is blocked and cut. The corresponding part of the cut tube in the state where the internal flow path is blocked is solidified, so that the two containers are separated from each other in a closed state through the corresponding part of the tube.

technical problem to be solved

Embodiments of the present disclosure provide a device and method capable of significantly reducing the contamination of serum and the possibility of infection of a patient in a preparation environment and a use environment where serum is used as a medical solution.

In the prior art, there are problems in that operational trouble may arise due to the process of cutting the tube using a heating cutter, and a part of serum may be unnecessarily heated. Embodiments of the present disclosure address the problems of the prior art described above.

means of solving problems

One aspect of the present disclosure provides embodiments of a serum dispensing device. The serum dispensing device of a representative embodiment includes: an inflow part having an inflow port for inflowing serum; a plurality of container connection parts configured to be combined and detachable with a plurality of containers; a plurality of distribution channel parts correspondingly arranged in the plurality of containers a container connecting portion, and having dispensing holes, so that the serum flows out into the containers respectively combined with the corresponding container connecting portions; and a plurality of recovery channel portions correspondingly arranged at the plurality of container connecting portions, And there are recovery holes to allow the serum to flow in from the containers respectively bound to the corresponding container connection parts. The serum distribution device forms an initial flow path connected from the inflow port to the distribution hole of any one of the plurality of distribution channel parts. The serum distribution device forms a connection flow path connecting the recovery hole of any one recovery channel part of the plurality of recovery channel parts and the distribution hole of any one distribution channel part of the plurality of distribution channel parts .

Another aspect of the present disclosure provides embodiments of serum distribution kits. A serum dispensing kit of a representative embodiment includes: a plurality of containers configured to receive serum; and a serum dispensing device configured to dispense the serum to the plurality of containers. The serum distributing device includes: an inflow part having an inflow port for inflowing the serum; a plurality of container connection parts configured to be able to be combined and separated from the plurality of containers; a plurality of distribution channel parts correspondingly arranged in the plurality of containers; a container connection part, and has a dispensing hole, so that the serum flows out into the container respectively combined with the corresponding container connection part; and a plurality of recovery channel parts, correspondingly arranged in the plurality of container connection parts , and has a recovery hole, so that the serum flows in from the containers respectively bound to the corresponding container connection parts. The serum distribution kit forms an initial flow path connected from the inflow port to the distribution hole of any one of the plurality of distribution channel parts. The serum distribution kit forms a connecting flow connecting the recovery hole of any one recovery channel part of the plurality of recovery channel parts and the distribution hole of any one distribution channel part of the plurality of distribution channel parts road.

The effect of the invention

According to the embodiments of the present disclosure, it is possible to conveniently maintain a closed state between the serum and the outside in the preparation environment and the use environment where the serum is used as a medical solution.

According to the embodiments of the present disclosure, the convenience of the operation of distributing a small amount of serum into a plurality of containers can be significantly improved.

According to an embodiment of the present disclosure, it is possible to dispense serum to a plurality of containers and separate the plurality of containers from each other without using a heated cutter.

The embodiments of the present disclosure are examples for the purpose of explaining the technical idea of the present disclosure. The scope of rights of the present disclosure is not limited to the embodiments presented below or specific descriptions of these embodiments.

Unless otherwise defined, all technical and scientific terms used in the present disclosure have the same meaning as commonly understood by those of ordinary skill in the art to which the present disclosure belongs. All terms used in the present disclosure are selected for the purpose of explaining the present disclosure more clearly, and are not selected for limiting the scope of rights of the present disclosure.

Expressions such as "comprising", "provided with", and "having" used in the present disclosure, unless otherwise mentioned in the statement or sentence containing the expression, should be understood as open terms that include the possibility of other embodiments ( open-ended terms).

Unless otherwise specified, singular expressions described in the present disclosure may include plural meanings, and are equally applicable to singular expressions described in the claims for inventions.

Expressions such as "first" and "second" used in the present disclosure are used to distinguish a plurality of constituent elements from one another, and do not limit the order or importance of the constituent elements.

The direction indicators such as "above" and "upper" used in this disclosure refer to the direction of the arrow U shown in Figure 5, Figure 6 and Figure 9, and the direction indicators such as "below" and "down" refer to the , the direction of the arrow D shown in FIG. 6 and FIG. 9 . This is to explain the present disclosure so that it can be clearly understood that each direction may be defined differently depending on where the reference is set.

Hereinafter, embodiments of the present disclosure will be described with reference to the drawings. In the drawings, the same or corresponding components are given the same reference symbols. In addition, in the description of the following embodiments, repeated description of the same or corresponding constituent elements may be omitted. However, even if descriptions related to constituent elements are omitted, it is not intended that such constituent elements are not included in any embodiment.

FIG. 1 is a diagram showing an elevation or a cross section of each device of a serum distribution kit 1 according to an embodiment of the present disclosure.

Referring to FIG. 1 , the serum dispensing kit 1 includes a container 200 configured to contain serum. Only one container 200 is shown in FIG. 1 , but the serum dispensing set 1 comprises a plurality of containers 200 . The serum distribution kit 1 includes a serum distribution device 100 configured to dispense serum to a plurality of containers 200 .

The serum dispensing device 100 may include a chamber connecting body 100A configured to be coupled and detached from the blood chamber 510 . The serum dispensing device 100 may include a dispensing body 100B configured such that a plurality of containers can be coupled and detached thereto. The chamber connection body 100A and the distribution body 100B may be combined with each other. The serum distribution device 100 may include an end cap 100C. The end cap 100C may be configured to be engageable with the dispensing body 100B.

The serum distribution device 100 includes an inflow part 110 having an inflow port 110h through which serum flows. The serum dispensing device 100 may include an outflow portion 120 having an outflow port 120h through which air flows out. The serum dispensing device 100 includes a plurality of container connection parts 130 configured to be coupled and detached from a plurality of containers 200 . The serum distribution device 100 includes a plurality of distribution channel parts 140 , and the plurality of distribution channel parts 140 are correspondingly arranged in a plurality of container connection parts 130 . The plurality of dispensing channel parts 140 have dispensing holes 140h to flow serum into the containers 200 respectively coupled to the corresponding container connecting parts 130 . The serum distribution device 100 includes a plurality of recovery channel parts 150 , and the plurality of recovery channel parts 150 are correspondingly arranged in the plurality of container connection parts 130 . The plurality of recovery channel parts 150 have recovery holes 150h so that serum flows in from the containers 200 respectively coupled to the corresponding container connection parts 130 .

The end cap 100C may be configured to be able to be combined with the outflow portion 120 . The end cap 100C may be configured to allow the passage of air but not serum. The end cap 100C may have a vent hole for exhausting air to the outside. The end cap 100C may include a hydrophobicity screen disposed at a location upstream of the vent. The air flowing out through the outflow port 120h of the outflow part 120 may be discharged to the outside through the vent hole after passing through the hydrophobicity screening procedure of the end cap 100C. The serum flowing out through the outflow port 120h of the outflow part 120 cannot pass the hydrophobicity screening procedure of the end cap 100C, and thus is not discharged to the outside.

FIG. 2 is an elevational view of a stopper 300 according to an embodiment of the present disclosure.

Referring to FIG. 2 , the serum dispensing set 1 may further include a stopper 300 configured to be arranged in a plurality of containers 200 . The stopper 300 may block in the form of preventing the serum containing space in the container 200 from exceeding a predetermined volume. The stopper 300 may include a stopper 310 in contact with the bottom of the plunger of the container 200 . The stopper 300 may include a plurality of stoppers 310 corresponding to the plurality of containers 200 . The stopper 300 may include a base 330 supporting a plurality of stoppers 310 . A plurality of limiting parts 310 may protrude upward from the base 330 . The plurality of limiting parts 310 may be formed in a column shape.

Fig. 3 is an elevational view of a blood collection device 400 and a centrifugal balance device 500 according to an embodiment of the present disclosure.

Referring to FIG. 3 , the serum distribution set 1 may further include a centrifugal balance device 500 configured to separate serum from collected blood. Centrifugal balancing device 500 may include a blood chamber 510 for containing collected blood. The centrifugal balance device 500 may include a centrifugal chamber 530 configured to be combined with and separated from the blood chamber 510 .

The blood chamber 510 forms a blood containing space therein. The blood chamber 510 can be configured to be combined with and detached from the inflow part 110 of the serum distribution device 100 . The blood chamber 510 may have an injection part 511 configured to connect the blood storage space with the inflow port 110 h of the inflow part 110 when combined with the inflow part 110 . The injection part 511 may be configured to close the blood containing space when separated from the inflow part 110 .

The blood chamber 510 may include a blood housing 513 forming the blood receiving space inside thereof. The blood chamber 510 may include a blood piston 515 slidably disposed on the inner side of the blood housing 513 . Together with the inner side of the blood housing 513 , the blood piston 515 can delimit the blood receiving space.

The centrifugal chamber 530 may form a centrifugal space therein. The centrifugal space can contain liquid. The centrifugal chamber 530 may include a centrifugal inlet 531 connected to the injection part 511 of the blood chamber 510 in a state of being combined with the blood chamber 510 . The centrifugation chamber 530 may include a combination guide 532 for guiding a combination position of the centrifugation chamber 530 and the blood chamber 510 so that the injection part 511 and the centrifugation inlet 531 are connected to each other. The outer peripheral surface of the blood chamber 510 may be guided and inserted into the inner peripheral surface of the coupling guide 532 .

The centrifuge chamber 530 may include a centrifuge housing 533 forming the centrifuge accommodation space inside it. The centrifugal chamber 530 may include a centrifugal piston 535 slidably disposed on an inner surface of the centrifugal housing 533 . The centrifugal piston 535 can divide the centrifugal receiving space together with the inner side of the centrifugal housing 533 .

When the injection part 511 of the blood chamber 510 is combined with the centrifugal chamber 530, the blood containing space can be connected with the centrifugal space. The injection part 511 may be configured to close the blood containing space when separated from the centrifugation chamber 530 . The injection part 511 may include a pressurization valve (not shown) having a hole that opens when pressed from the outside. In a state where the blood chamber 510 and the centrifugation chamber 530 are combined with each other, the blood containing space and the centrifugation space may be connected to each other through the injection part 511 and the centrifugation inlet 531 .

The centrifugal balance device 500 may include a piston rod 550 configured to be coupled and detached from the blood chamber 510 . Piston rod 550 may be configured to engage and detach from blood piston 515 . The piston rod 550 may be configured to be coupled to and detached from the centrifuge chamber 530 while being separated from the blood chamber 510 . The piston rod 550 may be configured to be coupled and detached from the centrifugal piston 535 . The piston rod 550 may include a piston coupling 551 configured to be coupled to the blood piston 515 . The piston coupling part 551 can be configured to be coupled to the centrifugal piston 535 . For example, the piston engagement portion 551 may include threads configured to engage with threads formed on the blood piston 515 and threads formed on the centrifuge piston.

The piston rod 550 may be configured to protrude to the outside of the blood housing 513 in a state coupled with the blood piston 515 . The piston rod 550 may include an operation portion 553 protruding to the outside of the blood housing 513 in a state of being coupled with the blood piston 515 . A piston coupling part 551 may be formed at one end of the piston rod 550 , and an operating part 553 may be formed at the other end of the piston rod 550 .

The serum distribution kit 1 may include a blood collection device 400 configured to collect blood from a patient. Both ends 410 and 420 of the blood collection device 400 can be configured to be connected to the injection part 511 of the blood chamber 510 and the patient, respectively. One end 410 of the blood collection device 400 may be formed with a thread that can be combined with the injection part 511 . The other end 420 of the blood collection device 400 may be formed with a hole inserted into the patient's skin to allow blood to flow thereinto. The blood collection device 400 may be configured to guide blood from the patient to move into the blood containing space of the blood chamber 510 .

FIG. 4 is a perspective view of a sterilization screening program according to an embodiment of the present disclosure.

Referring to FIG. 4 , the serum dispensing set 1 may further include a sterility screening program 600 configured to be combined with the inlet 210 h of the container 200 . The bactericidal screening program 600 may include a screening program coupling part 610 forming a thread that may be coupled with the inlet 210 h of the container 200 . The sterilization screening program 600 can use various products having a sterilization function. When the sterilizing screening program 600 is combined with the container 200 , it can prevent bacteria from invading the serum in the container 200 from the outside.

Fig. 5 is a perspective view showing a combined state of a plurality of containers and a serum dispensing device according to an embodiment of the present disclosure. FIG. 6 is a perspective view showing the situation of FIG. 5 from a different angle. Fig. 7 is a perspective view showing a separated state of a plurality of containers and a serum dispensing device according to an embodiment of the present disclosure. The figure shows that the number of containers 200 is five, but this is only an example, and the number of containers 200 and the number of corresponding container connection parts 130 are not limited thereto.

Referring to FIGS. 5 to 7 , a plurality of containers 200 may be detachably coupled to the serum dispensing device 100 . The plurality of container connection parts 130 of the serum distribution device 100 can be configured so that the plurality of containers 200 can be connected to the plurality of container connection parts 130 in the upper side U. A plurality of container connection parts 130 may be arranged in parallel. In a state where the plurality of containers 200 and the serum distribution device 100 are coupled to each other, the inlets of the plurality of containers 200 may be arranged facing upward U. As the serum entering the serum storage space in the container 200 through the distribution hole 140h of the distribution channel part 140 is gradually filled from the bottom of the serum storage space, the air in the serum storage space can pass through the recovery hole 150h of the recovery channel part 150 discharge.

The dispensing body 100B of the serum dispensing device 100 may include a body coupling portion 101 configured to be coupled with the chamber connecting body 100A. The body coupling part 101 may be formed with threads engaged with threads of the chamber connection body 100A. A hole connected to a starting flow path Ps described later may be formed in a central portion of the main body coupling portion 101 . In a state where the chamber connection body 100A is combined with the distribution body 100B, serum can flow from the inside of the chamber connection body 100A to the inside of the distribution body 100B through the hole of the body coupling part 101 .

A plurality of container connection parts 130 may be formed protruding toward the lower side D of the serum dispensing device 100 . A plurality of container connection parts 130 may be formed spaced apart from each other in a direction perpendicular to the up-down direction. The outflow portion 120 may be formed to protrude toward the upper side U of the serum distribution device 100 . The body coupling part 101 may be formed to protrude toward the upper side U of the distribution body 100B.

FIG. 8 is an exploded perspective view of the plurality of containers and the serum dispensing device shown in FIG. 7 .

Referring to FIG. 8 , the distribution body 100B may include a first part 100B1 and a second part 100B2 combined with each other. The first part 100B1 and the second part 100B2 are combined with each other, so that a part of the flow path of the serum distribution device 100 can be formed between the first part 100B1 and the second part 100B2. A plurality of container connection parts 130 may be formed in the first part 100B1. The outflow part 120 and the body combining part 101 may be formed at the second part 100B2.

Fig. 9 is a cross-sectional view of the serum dispensing device of Fig. 1 , a plurality of containers, and the stopper of Fig. 2 in a state in which an internal flow path can be seen. Fig. 10 is an enlarged sectional perspective view of a portion where the serum dispensing device and the container are combined with each other in Fig. 9 .

Referring to FIGS. 8 to 10 , the plurality of containers 200 may include a container housing 210 and a plunger 230 , respectively. The inside of the container housing 210 forms a serum containing space 200s. The top of the container case 210 is formed with an inlet 210h of the container 200 . The inlet 210h is connected to the serum containing space 200s. The dispensing channel part 140 of the serum dispensing device 100 can be inserted into the container 200 through the inlet 210h of the container. The recovery channel part 150 of the serum distribution device 100 may be inserted into the container 200 through the inlet 210h of the container. The container housing 210 may include a container coupling portion 211 configured to be coupled with the container connection portion 130 of the serum dispensing device 100 . The bottom of the container housing 210 may be formed with a hole inserted into the stopper 310 of the stopper 300 .

The plunger 230 may be slidably disposed on the inner surface of the container case 210 . The plunger 230 may divide the serum containing space 200s together with the inner surface of the container case 210 . The plunger 230 can slide relative to the container housing 210 to change the volume of the serum containing space 200s. The plunger 230 may be arranged at a predetermined position of the container housing 210 so as to have a predetermined volume of the serum containing space 200s in a state before serum is contained in the serum containing space 200s. The stopper 300 may be configured to be in contact with the plunger 230 to prevent the plunger 230 from sliding beyond a predetermined position relative to the container housing 210 in the direction D in which the serum storage space 200s is expanded.

Referring to FIG. 9 , the serum distribution device 100 forms a channel for guiding the flow of serum. The flow path of the serum distribution device 100 can guide the flow of air and serum. The flow paths of the serum distribution device 100 may include a starting flow path Ps. There may be one initial flow path Ps. The flow path of the serum distribution device 100 may include a connecting flow path Pc. A plurality of connection channels Pc may be provided. The flow path of the serum distribution device 100 may include an ending flow path Pe. There may be one end flow path Pe.

The initial flow path Ps is connected from the inflow port 100h to the distribution hole 140h of any one of the distribution channel parts 140 . The initial flow path Ps can guide the serum to flow from the inflow port 100h to the serum containing space 200s of any one container 200 among the plurality of containers 200 .

The connection channel Pc connects the recovery hole 150h of any one of the plurality of recovery channel parts 150 and the distribution hole 140h of any one of the plurality of distribution channel parts 140 . The connecting flow path Pc can guide the serum to flow from the serum containing space 200s of any container 200 to the serum containing space 200s of another container 200 . For example, any connecting flow path Pc can guide serum from the serum holding space 200s of any one container 200 to the serum holding space 200s of another container 200, and another connecting flow path Pc can lead serum from the other container 200 The serum containing space 200s of another container 200 flows to the serum containing space 200s.

The end flow path Pe connects the recovery hole 150h of any one of the plurality of recovery channel parts 150 to the outflow port 120h. The end flow path Pe can guide the serum to flow from the serum storage space 200s of a certain container 200 to the outflow port 120h.

The serum dispensing device 100 can be configured to allow serum to flow sequentially along the initial flow path Ps and the connecting flow path Pc in a state where the plurality of containers 200 are connected to the plurality of container connection parts 130 . The starting flow path Ps and the connecting flow path Pc can be connected in series through the serum containing space 200s. The two connection channels Pc can be connected in series through the serum containing space 200s.

The serum dispensing device 100 can be configured to allow air to flow sequentially along the connecting flow path Pc and the ending flow path Pe in a state where the plurality of containers 200 are connected to the plurality of container connection parts 130 . Any connecting flow path Pc and the end flow path Pe can be connected in series through the serum containing space 200s.

The serum distribution device 100 can be configured to allow air to flow sequentially along the start flow path Ps, the connection flow path Pc, and the end flow path Pe in a state where the plurality of containers 200 are connected to the plurality of container connection parts 130 . One start flow path Ps, a plurality of connection flow paths Pc, and one end flow path Pe may be sequentially connected in series.

Referring to FIGS. 8 to 10 , the distribution channel part 140 and the recovery channel part 150 respectively form channels constituting a part of the flow path of the serum distribution device 100 . In the present embodiment, the distribution channel part 140 is described as having a needle shape, but the distribution channel part 140 may be formed in other various shapes forming channels. In addition, in the present embodiment, the recovery channel part 150 is described as having a needle shape, but the recovery channel part 150 may be formed in other various shapes forming channels. Hereinafter, although description is made on the basis that the distribution channel part 140 and the recovery channel part 150 are respectively needle-shaped, the present disclosure is not limited thereto.

The dispensing channel part 140 may include a dispensing needle 140 fixed on the container connection part 130 . The dispensing needle 140 may be fixed at a central portion of the container connection part 130 . The dispensing needle 140 may protrude downward from the container connection part 130 . A protruding end of the dispensing needle 140 may be formed with a dispensing hole 140h. The dispensing needle 140 can be designed such that said protruding end of the dispensing needle 140 can be introduced into the container 200 . The protruding end of the dispensing needle 140 may be introduced into the container 200 in a state where the container 200 is combined with the container connection part 130 .

The recovery passage part 150 may include a recovery needle 150 fixed to the container connection part 130 to which the dispensing needle 140 is fixed. The recovery needle 150 may be fixed at a central portion of the container connection part 130 . The recovery needle 150 may protrude downward from the container connection part 130 . A protruding end of the recovery needle 150 may be formed with a recovery hole 150h. The recovery needle 150 may be configured such that the protruding end of the recovery needle 150 may be introduced into the container 200 . The protruding end of the recovery needle 150 may be introduced into the container 200 in a state where the container 200 is combined with the container connection part 130 .

The following description will be made on the basis of the dispensing needle 140 and the recovery needle 150 disposed on a certain container connection portion 130 . Dispensing needle 140 and retrieval needle 150 may be arranged in parallel. Dispensing needle 140 may be longer than retrieval needle 150 . Dispensing needle 140 may protrude longer than retrieval needle 150 . The protruding end of the recovery needle 150 may be located closer to the upper side than the protruding end of the dispensing needle 140 . Therefore, when the serum that enters the serum containing space 200s in the container 200 through the dispensing hole 140h of the dispensing needle 140 is gradually filled from the bottom of the serum containing space 200s in the state where the container 200 is coupled to the serum dispensing device 100 upward, recovery can be improved. The recovery hole 150h of the needle 150 is submerged by the serum level, and before the recovery hole 150h is submerged by the serum, the air in the serum storage space 200s can be smoothly discharged through the recovery hole 150h.

The plunger 230 of the container 200 may be located closer to the lower side than the protruding end of the dispensing needle 140 in a state where the container 200 is coupled to the container connection part 130 at the upper side. Therefore, the dispensing needle 140 can be prevented from being interfered by the plunger 230 .

The serum distribution device 100 may include a partition wall 160 disposed between the distribution needle 140 and the recovery needle 150 . A plurality of partition walls 160 may be provided corresponding to the plurality of distribution needles 140 and the plurality of recovery needles 150 . The partition wall 160 can separate the flow path connected with the dispensing needle 140 and the flow path connected with the recovery needle 150 . For example, in the portion shown in FIG. 10 , the partition wall 160 separates the starting flow path Ps to which the dispensing needle 140 is connected and the connecting flow path Pc to which the recovery needle 150 is connected. The partition wall 160 may be disposed between the fixed end 141 of the dispensing needle 140 and the fixed end 151 of the recovery needle 150 . The fixed end portion 141 of the dispensing needle 140 is fixed to the container connecting portion 130 . The fixed end portion 151 of the recovery needle 150 is fixed to the container connection portion 130 .

The serum dispensing device 100 may include a dispensing needle seal 170 disposed about the fixed end 141 of the dispensing needle 140 . The distribution needle sealer 170 can prevent serum from leaking from the flow path connected to the distribution needle 140 along the outer peripheral surface of the distribution needle 140 .

The serum dispensing device 100 may include a recovery needle sealer 180 disposed about the fixed end 151 of the recovery needle 150 . The recovery needle sealer 180 can prevent serum from leaking from the flow path connected to the recovery needle 150 along the outer peripheral surface of the recovery needle 150 .

The partition wall 160 may be disposed between the dispensing needle sealer 170 and the recovery needle sealer 180 . Dispensing needle sealer 170 may include a flat surface that contacts partition wall 160 . The recovery needle sealer 180 may include a flat surface in contact with the partition wall 160 .

The inflow part 110 of the serum distribution device 100 may include a blood chamber connection part 111 configured to be coupled to and detached from the blood chamber 510 containing serum. An inflow port 110h serving as an upstream end of the initial flow path Ps may be formed in the blood chamber connection portion 111 . In a state where the serum distribution device 100 is combined with the blood chamber 510 , the blood chamber connection part 111 may be in contact with the injection part 511 of the blood chamber 510 .

The dispensing body 100B may include an end cap connection part 121 configured to be coupled and detached from the end cap 100C. An outflow port 120h serving as a downstream end of the end flow path Pe may be formed in the cap connection portion 121 .

The serum distribution device 100 may further include a valve 190 configured to open and close the initial flow path Ps. The valve 190 may be disposed on the chamber connection body 100A. The valve 190 may be configured to change the opening and closing of the starting flow path Ps by rotation. For example, the direction of rotation of valve 190 is shown by arrows in FIG. 9 .

FIG. 11 is a cross-sectional view illustrating flows of serum and air at a portion where the serum dispensing device 100 and the container 200 of FIG. 9 are combined with each other. Referring to FIG. 11 , the serum S can flow into the serum containing space 200s of the container 200 through the dispensing hole 140h (refer to arrow A1 ). As the serum S flows into the serum storage space 200s, the air in the serum storage space 200s can flow into the connection channel Pc through the recovery hole 150h (refer to arrow A2).

FIG. 12 is a cross-sectional view showing the flow of serum after the container 200 in FIG. 11 is filled with serum. Referring to FIG. 12 , when the serum S reaches a predetermined water level in the serum containing space 200s, the recovery hole 150h will be flooded with the serum S. In the state where the recovery hole 150h is flooded with serum S, the serum S continues to flow into the serum storage space 200s through the distribution hole 140h (refer to arrow A1), and the serum S in the serum storage space 200s flows into the connecting flow path Pc through the recovery hole 150h (refer to Arrow A3), thus flowing into the serum holding space of the next container. The process of filling the next container with serum is the same as described above with reference to FIGS. 11 and 12 .

FIG. 13 is a diagram sequentially showing the process of collecting blood using the serum distribution kit 1 . Referring to FIG. 13 , the blood collection process of an embodiment is described in sequence as follows.

Referring to (a) of FIG. 13 , the blood collection device 400 is combined with the blood chamber 510 . In addition, the piston rod 550 is combined with the blood chamber 510 .

Referring to (b) of FIG. 13 , the blood collection device 400 is connected to the patient to collect blood B of the patient. The collected blood B is filled into the blood containing space in the blood housing 513 formed by pulling the piston rod 550 .

Referring to (c) of FIG. 13 , the blood collection device 400 is separated from the blood chamber 510 . Additionally, the piston rod 550 is separated from the blood chamber 510 .

Referring to (d) of FIG. 13 , the blood chamber 510 containing the blood B and the centrifugal chamber 530 are combined with each other.

FIG. 14 is a diagram sequentially showing the process of centrifuging serum from blood using the serum distribution kit 1 . Referring to FIG. 14 , the serum centrifugation process of an embodiment is described as follows.

Referring to (a) of FIG. 14 , the blood chamber 510 containing the blood B is combined with the centrifugation chamber 530 to prepare for centrifugation.

Referring to (b) of FIG. 14 , the blood chamber 510 and the centrifugal chamber 530 combined with each other are put into a centrifuge (not shown), and the centrifuge is operated. Part of the blood may move to the inside of the centrifugal chamber 530 through the injection part 511 of the blood chamber 510 . After a predetermined time elapses, blood B is separated into serum S and clot C due to the difference in specific gravity. Under the action of centrifugal force, the centrifugal piston 535 slides to one side relative to the centrifugal housing 533 to increase the centrifugal space, and the blood piston 515 slides to the one side relative to the blood housing 513 to reduce the blood containing space. The centrifugal space may be filled with blood clots. The boundaries of the serum S and the blood clot C separated from each other may not coincide with the boundaries of the centrifuge space and the blood holding space.

Referring to (c) of FIG. 14 , the piston rod 550 can be combined with the blood chamber 510 or the centrifugal chamber 530 to adjust the volume of the blood containing space and the volume of the centrifugal space so that the serum S and the blood clot C The boundary of is consistent with the boundary of the blood containing space and the centrifugal space. In the example of FIG. 14( c ), the centrifugal piston 535 is pushed by the piston rod 550 , and a small amount of serum S that flows into the centrifugal chamber 530 through centrifugation is introduced into the blood chamber 510 .

FIG. 15 is a diagram showing a process of separating and diluting serum from a blood clot using the serum distribution set 1 . Referring to FIG. 15 , the process of separating serum and blood clot and diluting serum in an embodiment will be described in sequence as follows.

Referring to (a) of FIG. 15 , when the serum S is collected into the blood chamber 510 (refer to (c) of FIG. 14 ), the blood chamber 510 is separated from the centrifugal chamber 530 in which the clot C is collected.

Referring to (b) of FIG. 15 , the piston rod 550 is combined with the blood chamber 510 filled with serum S. Referring to FIG.

Referring to (c) of FIG. 15 , physiological saline and/or other medicines are added into the blood chamber 510 according to directions to dilute the serum S in the blood chamber 510 .

In (b) and (c) of Figure 15, undiluted serum is plotted as S0 and diluted serum is plotted as S1, but references to "serum" in other parts of this disclosure can be understood to include undiluted serum and diluted serum concept.

FIG. 16 is a diagram illustrating a situation in which a blood chamber 510 containing serum S is connected to the serum distribution device 100 according to an embodiment. Referring to FIG. 16 , when the blood chamber 510 containing diluted serum S is combined with the serum distribution device 100 , the valve 190 may remain in a state of closing the flow path of the serum distribution device 100 .

FIG. 17 is a diagram showing a state in which a pressurizing device 700 is attached to the blood chamber 510 in FIG. 16 and a plurality of containers 200 are combined on the serum distribution device 100 .

The serum distribution kit 1 may further include a pressurizing device 700 configured to press the blood piston 515 of the blood chamber 510 in a state where the blood chamber 510 is combined with the inflow part 110 of the serum distribution device 100 . Pressurize. The pressurizing device 700 can pressurize the blood piston 515 using the piston rod 550 as a medium.

The pressurizing device 700 may include a stand portion 790 on which the blood chamber 510 is seated. The pressurizing device 700 may include an elastic member 710 for providing an elastic force to pressurize the blood piston 515 . For example, the elastic member 710 may include a spring. One end of the elastic member 710 is locked on the bracket part 790 , and the other end of the elastic member 710 can push the pressing part 730 . The pressurizing device 700 may include a pressurizing part 730 that presses the piston rod 550 . The pressing part 730 may be pushed to one side (lower side) by the other end of the elastic member 710 , thereby pushing the piston rod 550 . The pressing part 730 may be configured to be slidable along the bracket part 790 . The pressurizing device 700 may include a joystick 750 rotatably disposed on a bracket part 790 . The pressurizing device 700 may include a joystick connection part 770 , one end of which is rotatably connected to the joystick 750 , and the other end is rotatably disposed on the pressurization part 730 . When the user pulls the joystick 750 to rotate, the pressing part 730 slides to the other side (upper side), and the elastic member 710 is elastically compressed. Then, when the blood chamber 510 is seated on the bracket part 790 , the pressing part 730 may continuously press the piston rod 550 by the elastic restoring force of the elastic member 710 .

FIG. 18 shows that stoppers 300 are arranged in multiple containers 200 according to an embodiment, and serum S is distributed into multiple containers 200 in the state where the end cap 100C is combined with the distribution main body 100B in the serum distribution device 100 state diagram. Referring to FIG. 18 , valve 190 may be used to open the flow path of serum dispensing device 100 and pressurize blood piston 515 of blood chamber 510 (see arrow M1 ). The serum S in the blood chamber 510 is sequentially filled into the plurality of containers 200, and the air in the plurality of containers 200 and the flow path is exhausted to the outside through the end cap 100C. Thereafter, the plurality of containers 200 can be separated from the serum distribution device 100 .

FIG. 19 is a perspective view illustrating a combined state of a serum distribution device 100' and a plurality of containers according to another embodiment of the present disclosure. Hereinafter, with reference to FIG. 19 , a serum distribution device 100 ′ of another embodiment will be described as follows around differences from the serum distribution device 100 of the above-mentioned one embodiment.

The serum distribution device 100' may be provided with multiple initial flow paths. The serum distribution device 100' may be provided with a plurality of said end flow paths. In the serum distribution device 100', the number of the initial flow paths may be equal to the number of the end flow paths. The flow path of the serum distribution device 100' may include a plurality of branch flow paths branching from each other. The plurality of branch flow paths may branch from each other through the plurality of initial flow paths. The number of the branch flow paths is the same as the number of the initial flow paths. The plurality of branch flow paths may branch from each other based on the inflow port 110h. Each of the plurality of branch flow paths has an outflow port 120h at a downstream side end.

The serum distribution device 100' may further include a branch part 103 configured such that the plurality of initial flow paths branch off from each other. The serum distribution device 100' may further include a plurality of branch parts 105, and the plurality of branch parts 105 respectively correspond to the plurality of branch channels and form a part of the branch channels. The plurality of branch portions 105 may extend in the horizontal direction. A plurality of branch flow parts may be arranged in parallel to each other.

Each of the plurality of branch flow paths may be configured such that serum can sequentially flow along the initial flow path and the connection flow path in a state where the plurality of containers 200 are combined with the plurality of container connection parts 130 . Each of the plurality of branch flow paths may be configured such that air can sequentially flow along the connection flow path and the end flow path in a state where the plurality of containers 200 are connected to the plurality of container connection portions 130 . Each of the plurality of branch flow paths may be configured such that, in a state where the plurality of containers 200 are combined with the plurality of container connection parts 130, the air may sequentially flow along the initial flow path, the connection flow path, and the The end flow path flows. In each of the plurality of branch flow paths, one start flow path Ps, a plurality of connection flow paths Pc, and one end flow path Pe may be sequentially connected in series.

FIG. 20 is a perspective view illustrating a combined state of a serum distribution device 100 ″ and a plurality of containers according to still another embodiment of the present disclosure. Hereinafter, with reference to FIG. 20 , the serum distribution device 100 ″ of still another embodiment will be described as follows around the differences from the serum distribution device 100 ′ of another embodiment described above.

The plurality of branch flow parts 105 of the serum distribution device 100 ″ may be radially arranged. A plurality of branch parts 105 of the serum distribution device 100 ″ may be arranged along a circumferential direction centered on the branch part 103 .

Although the technical ideas of the present disclosure have been described through the examples shown in the above embodiments and drawings, it should be understood that the technical ideas and technical ideas of the present disclosure can be understood without departing from the technical ideas and Various substitutions, modifications and changes are made within the scope. In addition, such substitutions, modifications and alterations should be deemed to fall within the scope of the appended invention claims.

B: blood S, S0, S1: Serum C: blood clot Ps: initial flow path Pc: connect flow path Pe: end flow path 1: Serum Distribution Kit 100: Serum distribution device 100A: chamber connection body 100B: Assign subject 100C: End cap 100h: Inflow port 101: Main body junction 110: Inflow part 110h: Inflow port 111: blood chamber connection part 120: outflow part 120h: outlet 121: End cap connection part 130: container connection part 140: distribution channel part, distribution needle 140h: distribution hole 141: fixed end of dispensing needle 150: recovery channel, recovery needle 150h: Recovery hole 151: Fixed end of recovery needle 160: partition wall 170: Dispensing needle sealer 180: Recovery Needle Sealer 190: valve 200: container 200s: serum storage space 210: Shell 210h: Entrance of the container 211: container junction 230: container plunger 300: stopper 400: blood collection device 500: centrifugal balance device 510: blood chamber 511: injection part 513: blood shell 515: blood piston 530: centrifugal chamber 531: centrifugal inlet 532: combination guide 533: centrifugal shell 535: centrifugal piston 550: piston rod 551: Piston junction 553: Operation Department 600: Sterilization screening program 700: pressurization device 710: elastic member 730: pressurized part 750: Joystick 770:Joystick connection 790: Bracket

FIG. 1 is a diagram showing an elevation or a cross section of each device of a serum distribution kit according to an embodiment of the present disclosure. FIG. 2 is an elevational view of a stopper according to an embodiment of the present disclosure. Fig. 3 is an elevational view of a blood collection device and a centrifugal balance device according to an embodiment of the present disclosure. FIG. 4 is a perspective view of a sterilization screening program according to an embodiment of the present disclosure. Fig. 5 is a perspective view showing a combined state of a serum distribution device and a plurality of containers according to an embodiment of the present disclosure. FIG. 6 is a perspective view showing the situation of FIG. 5 from a different angle. Fig. 7 is a perspective view showing a separated state of a plurality of containers and a serum dispensing device according to an embodiment of the present disclosure. FIG. 8 is an exploded perspective view of the plurality of containers and the serum dispensing device shown in FIG. 7 . Fig. 9 is a cross-sectional view of the serum dispensing device of Fig. 1 , a plurality of containers, and the stopper of Fig. 2 in a state in which an internal flow path can be seen. Fig. 10 is an enlarged sectional perspective view of a portion where the serum dispensing device and the container are combined with each other in Fig. 9 . 11 is a cross-sectional view showing the flow of serum and air at a portion where the serum dispensing device and the container are combined with each other in FIG. 9 . Fig. 12 is a sectional view showing the flow of serum after the inside of the container in Fig. 11 is filled with serum. Fig. 13 is a diagram sequentially showing the blood collection process of an embodiment. FIG. 14 is a diagram sequentially showing a process of centrifuging serum from blood according to an embodiment. 15 is a diagram illustrating a process of separating serum from blood clots and diluting, according to an embodiment. Fig. 16 is a diagram illustrating the connection of a blood chamber containing serum to a serum dispensing device, according to an embodiment. Fig. 17 is a diagram showing a state in which a pressurizing device is attached to the blood chamber in Fig. 16 and a plurality of containers are combined on the serum distribution device. Fig. 18 is a diagram showing a state in which serum is dispensed into a plurality of containers in a state in which stoppers are arranged in a plurality of containers and an end cap is coupled to a dispensing body in a serum dispensing device according to an embodiment. Fig. 19 is a perspective view showing a combined state of a serum distribution device and a plurality of containers according to another embodiment of the present disclosure. Fig. 20 is a perspective view showing a combined state of a serum distribution device and a plurality of containers according to still another embodiment of the present disclosure.

100: Serum distribution device

100A: chamber connection body

100B: Assign subject

100C: End cap

100h: Inflow port

110: Inflow part

111: blood chamber connection part

130: container connection part

140: distribution channel part, distribution needle

140h: distribution hole

150: recovery channel, recovery needle

150h: Recovery hole

190: valve

200: container

200s: serum storage space

210: Shell

230: container plunger

300: stopper

Ps: initial flow path

Pc: connect flow path

Pe: end flow path

Claims (20)

A serum distribution device, comprising: an inflow portion having an inlet for inflow of serum; A plurality of container connecting parts configured to be able to be combined and separated from a plurality of containers; A plurality of distribution channel parts are correspondingly arranged on the plurality of container connection parts, and have a distribution hole, so that the serum flows out into the containers respectively combined with the corresponding container connection parts; and a plurality of recovery channel parts are correspondingly arranged at the plurality of container connection parts, and have a recovery hole for allowing the serum to flow in from the containers respectively bound to the corresponding container connection parts, The serum distribution device forms an initial flow path connected from the inflow port to the distribution hole of any one of the plurality of distribution channel parts, The serum distribution device forms a connection flow connecting the recovery hole of any one recovery channel part of the plurality of recovery channel parts and the distribution hole of any one distribution channel part of the plurality of distribution channel parts road. The serum dispensing device according to claim 1, wherein, The serum distribution device is configured to allow the serum to flow sequentially along the initial flow path and the connecting flow path in a state where the plurality of containers are connected to the plurality of container connection portions. The serum dispensing device according to claim 1, wherein, also includes an outflow portion having an outlet through which air flows out, The serum distribution device forms an end flow path connecting the recovery hole and the outflow port of any one of the plurality of recovery channel parts. The serum dispensing device according to claim 3, wherein, The serum distribution device is configured to allow air to flow sequentially along the connecting flow path and the ending flow path in a state where the plurality of containers are connected to the plurality of container connection portions. The serum dispensing device as claimed in claim 4, wherein, Also included is an end cap configured to engage the outflow portion and configured to allow passage of the air but not passage of the serum. The serum dispensing device according to claim 1, wherein, The dispensing channel part includes a dispensing needle fixed to the container connecting part and protruding downward, and configured such that a protruding end formed with the dispensing hole can be introduced into the container. The serum dispensing device according to claim 6, wherein, The recovery channel part includes a recovery needle fixed to the container connection part where the dispensing needle is fixed and protruding downward, and is configured such that a protruding end formed with the recovery hole can introduced into the container, The protruding end of the recovery needle is located closer to the upper side than the protruding end of the dispensing needle. The serum dispensing device according to claim 6, wherein, The recovery channel part includes a recovery needle fixed to the container connection part where the dispensing needle is fixed and protruding downward, and is configured such that a protruding end formed with the recovery hole can introduced into the container, The serum distribution device further includes a partition wall disposed between the distribution needle and the recovery needle to separate the flow path connected to the distribution needle from the flow path connected to the recovery needle. The serum dispensing device according to claim 6, wherein, The recovery channel part includes a recovery needle fixed to the container connection part where the dispensing needle is fixed and protruding downward, and is configured such that a protruding end formed with the recovery hole can introduced into the container, The serum distribution device also includes: a dispensing needle sealer disposed around a fixed end of said dispensing needle fixed to said container connection; and A recovery needle sealer arranged around the fixed end of the recovery needle fixed to the container connection part. The serum dispensing device according to claim 1, wherein, The plurality of container connection portions is configured such that the plurality of containers can be coupled to the plurality of container connection portions upward. The serum dispensing device according to claim 1, wherein, The inflow part includes a blood chamber connection part configured to be able to combine with and separate from the blood chamber containing the serum, The serum distribution device also includes a valve configured to open and close the initial flow path. A serum distribution kit, comprising: a plurality of containers configured to hold serum; and a serum dispensing device configured to dispense said serum to said plurality of containers, The serum distribution device includes: an inflow portion having an inlet for inflowing the serum; a plurality of container connecting parts configured to be able to be combined and separated from the plurality of containers; A plurality of distribution channel parts are correspondingly arranged on the plurality of container connection parts, and have a distribution hole, so that the serum flows out into the containers respectively combined with the corresponding container connection parts; and a plurality of recovery channel parts are correspondingly arranged at the plurality of container connection parts, and have a recovery hole for allowing the serum to flow in from the containers respectively bound to the corresponding container connection parts, The serum distribution device forms an initial flow path connected from the inflow port to the distribution hole of any one of the plurality of distribution channel parts, The serum distribution device forms a connection flow connecting the recovery hole of any one recovery channel part of the plurality of recovery channel parts and the distribution hole of any one distribution channel part of the plurality of distribution channel parts road. The serum distribution kit as claimed in claim 12, wherein, The multiple containers respectively include: a container shell, the interior of which forms a serum containing space; and a plunger, slidably disposed on the inner surface of the container housing, and divides the serum containing space together with the inner surface of the container housing, The serum dispensing kit also includes a stopper configured to contact the plunger to prevent the plunger from exceeding a predetermined position relative to the container housing to allow the serum to Sliding in the direction in which the accommodation space expands. The serum distribution kit as claimed in claim 12, wherein, The dispensing channel part includes a dispensing needle fixed to the container connection part and protruding downward, and configured such that a protruding end formed with the dispensing hole can be introduced into the container, The multiple containers respectively include: a container shell, the inside of which forms a serum containing space; and a plunger slidably arranged on the inner surface of the container housing, together with the inner surface of the container housing to divide the serum storage space, in a state where the upper side of the container is coupled to the container connecting portion Next, the plunger is located at a lower side than the protruding end of the dispensing needle. The serum distribution kit as claimed in claim 12, wherein, It also includes a blood chamber, which forms a blood containing space inside, is configured to be able to be combined with and separated from the inflow portion, and has an injection portion configured to be connected to the inflow portion The blood receiving space is connected to the inflow port when the blood receiving part is combined, and the blood receiving space is closed when separated from the inflow part. The serum distribution kit as claimed in claim 15, wherein, further comprising a centrifugal chamber forming a centrifugal space therein and configured to be able to be combined and separated from the blood chamber, The injection part is configured to connect the blood containing space to the centrifugal space when coupled with the centrifugal chamber, and to close the blood containing space when separated from the centrifugal chamber. The serum distribution kit as claimed in claim 15, wherein, The blood chamber includes: a blood housing, the interior of which forms the blood containing space; and a blood piston, slidably disposed on the inner surface of the blood housing, and divides the blood containing space together with the inner surface of the blood housing, The serum dispensing kit further includes a piston rod configured to be coupled to and detached from the blood piston and configured to protrude to the blood housing when coupled to the blood piston. external. The serum distribution kit as claimed in claim 15, wherein, A blood collection device is also included, and the two ends of the blood collection device are configured to be respectively connectable to the injection part and the patient, and are configured to guide blood to move from the patient's body into the blood containing space. The serum distribution kit as claimed in claim 15, wherein, The blood chamber includes: a blood housing, the interior of which forms the blood containing space; and a blood piston, slidably disposed on the inner surface of the blood housing, and divides the blood containing space together with the inner surface of the blood housing, The serum distribution kit further includes a pressurizing device configured to pressurize the blood piston when the blood chamber is connected to the inflow part. The serum distribution kit as claimed in claim 12, wherein, It also includes a sterilizing screening program, which is configured to be able to be combined with the inlet of the container and has a sterilizing function.

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