KR102296426B1 - Method and apparatus for separating ginseng free water using azeotropic distillation - Google Patents
Method and apparatus for separating ginseng free water using azeotropic distillation Download PDFInfo
- Publication number
- KR102296426B1 KR102296426B1 KR1020200011167A KR20200011167A KR102296426B1 KR 102296426 B1 KR102296426 B1 KR 102296426B1 KR 1020200011167 A KR1020200011167 A KR 1020200011167A KR 20200011167 A KR20200011167 A KR 20200011167A KR 102296426 B1 KR102296426 B1 KR 102296426B1
- Authority
- KR
- South Korea
- Prior art keywords
- ginseng
- composition
- free water
- azeotropic distillation
- present
- Prior art date
Links
- 241000208340 Araliaceae Species 0.000 title claims abstract description 113
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title claims abstract description 113
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 113
- 235000008434 ginseng Nutrition 0.000 title claims abstract description 113
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 238000010533 azeotropic distillation Methods 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 85
- 239000002537 cosmetic Substances 0.000 claims abstract description 14
- 235000013305 food Nutrition 0.000 claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
- 238000000926 separation method Methods 0.000 claims description 23
- 230000003078 antioxidant effect Effects 0.000 claims description 10
- 230000000844 anti-bacterial effect Effects 0.000 claims description 7
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 239000003638 chemical reducing agent Substances 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 230000003266 anti-allergic effect Effects 0.000 claims description 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 6
- 230000003579 anti-obesity Effects 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 230000003779 hair growth Effects 0.000 claims description 6
- 230000007794 irritation Effects 0.000 claims description 6
- 230000003658 preventing hair loss Effects 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 229930195733 hydrocarbon Natural products 0.000 claims description 4
- 150000002430 hydrocarbons Chemical class 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- -1 tracanth Substances 0.000 description 10
- 238000001035 drying Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000013355 food flavoring agent Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 229940089161 ginsenoside Drugs 0.000 description 4
- 229930182494 ginsenoside Natural products 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- 241000606750 Actinobacillus Species 0.000 description 2
- 241000607534 Aeromonas Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000588807 Bordetella Species 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000589989 Helicobacter Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000589248 Legionella Species 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 241000588621 Moraxella Species 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 235000002789 Panax ginseng Nutrition 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000589516 Pseudomonas Species 0.000 description 2
- 241000607768 Shigella Species 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 241000607734 Yersinia <bacteria> Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000000378 calcium silicate Substances 0.000 description 2
- 229910052918 calcium silicate Inorganic materials 0.000 description 2
- 235000012241 calcium silicate Nutrition 0.000 description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241001148536 Bacteroides sp. Species 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 239000001512 FEMA 4601 Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 241000186781 Listeria Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 229960001714 calcium phosphate Drugs 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229960003340 calcium silicate Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 229940051810 licorice root extract Drugs 0.000 description 1
- 235000020725 licorice root extract Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/34—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
- B01D3/36—Azeotropic distillation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Birds (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
본 발명은 공비증류를 이용한 인삼 자유수의 분리 방법 및 장치에 관한 것이다. 본 발명은 또한 공비증류에 의해 분리된 인삼 자유수의 화장료 조성물, 식품 조성물 및 약제학적 조성물에서의 용도에 관한 것이다. The present invention relates to a method and apparatus for separating ginseng free water using azeotropic distillation. The present invention also relates to the use of free ginseng water separated by azeotropic distillation in cosmetic compositions, food compositions and pharmaceutical compositions.
Description
본 발명은 공비증류를 이용한 인삼 자유수의 분리 방법 및 장치에 관한 것이다. 본 발명은 또한 공비증류에 의해 분리된 인삼 자유수의 화장료 조성물, 식품 조성물 및 약제학적 조성물에서의 용도에 관한 것이다. The present invention relates to a method and apparatus for separating ginseng free water using azeotropic distillation. The present invention also relates to the use of free ginseng water separated by azeotropic distillation in cosmetic compositions, food compositions and pharmaceutical compositions.
인삼의 재배 후 갓 수확되는 형태의 말리지 않은 인삼을 수삼이라 하는데 수삼은 수분을 약 60~70%를 포함 하고 있다. 이는 수삼의 저장성을 약화시키는 원인이 되는데 백삼은 수삼을 그대로 또는 껍질을 살짝 벗겨내고 말려 건조한 삼이다. 수분 함량이 15% 이하가 되도록 건조한 인삼으로 형태에 따라 직삼(直蔘), 반곡삼(半曲蔘), 곡삼(曲蔘)으로 구분한다. 홍삼은 수삼을 수증기로 찐 다음 건조시킨 담홍갈색의 인삼이다. 태극삼은 홍삼과 백삼의 중간 상태의 제품이다. 수삼을 뜨거운 물속에 일정 시간 담가 익힌 다음 건조해 제조한다. Fresh ginseng, which is freshly harvested after cultivation, is called fresh ginseng. Fresh ginseng contains about 60-70% of water. This is a cause of weakening the storability of fresh ginseng. White ginseng is fresh ginseng as it is, or dried ginseng after peeling off the skin. Ginseng is dried so that the moisture content is 15% or less. Red ginseng is a light reddish-brown ginseng that is dried after steaming fresh ginseng. Taegeuk ginseng is an intermediate product between red ginseng and white ginseng. It is prepared by soaking fresh ginseng in hot water for a certain period of time and then drying it.
식품 속에 존재하는 수분은 자유로이 이동할 수 있는 수분과 식품성분에 결합한 수분, 이렇게 두 가지 형태로 구분하여 생각 할 수 있다. 전자를 유리수(free water)또는 자유수라고 하며, 식품을 건조시키면 쉽게 제거되고 0℃ 이하에서는 잘 얼게 되는 보통 형태의 수분을 말하는 것으로 식품 중에서 염류, 당류, 수용성 단백질 등을 용해하는 용매로서 작용하는 물이다. 이에 대하여 후자는 결합수(bound water) 또는 수화수(水和水 : water of hydration)라고 하며 식품중의 구성성분인 탄수화물이나 단백질 분자들에 강하게 흡착되어 있거나 수소결합(水素結合 : hydrogen bounding)에 의해 밀접하게 결합하고 있는 형태의 물로서 보통의 방법으로는 쉽게 분리시킬 수 없는 물을 말한다. Moisture present in food can be divided into two types: moisture that can move freely and moisture that is bound to food ingredients. The former is called free water or free water, and refers to water in a normal form that is easily removed when food is dried and freezes well below 0°C. it is water On the other hand, the latter is called bound water or water of hydration, and is strongly adsorbed to carbohydrates or protein molecules, which are components of food, or by hydrogen bounding. It refers to water in a form that is closely bound by water and cannot be easily separated by ordinary methods.
인삼의 건조 및 가공 과정에서 수삼의 약 60~ 70% 인 자유수는 모두 사라지게 되는데 연간 약 수삼의 생산량이 23,310 톤(2017년 생산량 기준, 인삼 통계 자료집)을 감안 할 때 약 16,000 톤의 천연유래의 인삼 유래 자유수가 모두 사라지고 있는 실정이다. During the drying and processing of ginseng, all free water, which is about 60 to 70% of fresh ginseng, disappears. Considering the annual production of about 23,310 tons of fresh ginseng (based on 2017 production, ginseng statistical data collection), about 16,000 tons of naturally-derived water is lost. All of the free water derived from ginseng is disappearing.
본 발명자들은 수삼으로부터 원래의 유효성분에 대한 손실을 최소화 하고 수삼으로부터 자유수를 효과적으로 분리하는 방법과 장치를 개발하기 위하여 예의 노력한 결과, 공비증류를 이용하여 인삼 자유수를 분리하는 경우 인삼의 주요성분인 진세노사이드의 함량을 변화시키기 않으면서도 종래 응축법에 비해 분리 효율을 현저히 증가시킬 수 있음을 확인하고 본 발명을 완성하기에 이르렀다. The present inventors have made diligent efforts to minimize the loss of the original active ingredient from fresh ginseng and to develop a method and device for effectively separating free water from fresh ginseng. It was confirmed that the separation efficiency can be significantly increased compared to the conventional condensation method without changing the content of phosphorus ginsenoside, and thus the present invention has been completed.
선행기술prior art
1. 대한민국 공개특허 10-2019-00242031. Republic of Korea Patent Publication 10-2019-0024203
본 발명은 공비증류를 이용한 인삼 자유수의 분리 방법을 제공하는 것을 목적으로 한다. An object of the present invention is to provide a method for separating ginseng free water using azeotropic distillation.
본 발명은 또한 공비증류를 이용한 인삼 자유수의 분리 장치를 제공하는 것을 목적으로 한다. Another object of the present invention is to provide an apparatus for separating ginseng free water using azeotropic distillation.
본 발명은 또한 공비증류를 이용하여 분리된 인삼 자유수의 용도, 예를 들면 화장료 조성물, 식품 조성물 및 약제학적 조성물에서의 용도를 제공하는 것을 목적으로 한다. Another object of the present invention is to provide the use of ginseng free water separated by azeotropic distillation, for example, in a cosmetic composition, a food composition and a pharmaceutical composition.
1. 인삼 자유수의 분리 방법1. Separation method of ginseng free water
본 발명은 공비증류를 이용한 인삼 자유수의 분리 방법을 제공하고자 하는 것으로, 상기 분리 방법은:The present invention is to provide a method for separating ginseng free water using azeotropic distillation, the separation method comprising:
(a) 수삼과 공비제의 혼합물을 가열하는 단계;(a) heating a mixture of fresh ginseng and an azeotrope;
(b) 상기 수삼과 공비제 혼합물을 감압조건에서 증류하는 단계; 및(b) distilling the fresh ginseng and azeotrope mixture under reduced pressure; and
(c) 상기 증류 중 발생하는 기체화된 인삼 자유수를 응축시켜 회수하는 단계를 포함하는 것을 특징으로 한다. (c) condensing and recovering the vaporized free ginseng water generated during the distillation.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 방법은 (d) 공비제를 저온 응축시켜 회수하는 단계를 추가로 포함하는 것을 특징으로 한다. 상기 회수된 공비제는 재사용될 수 있다. In the separation method of ginseng free water according to the present invention, the method is characterized in that it further comprises the step of (d) condensing the azeotrope at low temperature to recover it. The recovered azeotrope may be reused.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 수삼과 공비제의 중량비는 5:1 내지 15:1, 바람직하기는 10:1인 것을 특징으로 한다. In the separation method of ginseng free water according to the present invention, the weight ratio of the fresh ginseng and the azeotrope is 5:1 to 15:1, preferably 10:1.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 공비제는 끓는점이 60 ℃ 내지 120 ℃인 탄화수소인 것을 특징으로 한다. 예를 들면, 상기 공비제는 알코올, 바람직하기는 에탄올일 수 있다. In the separation method of ginseng free water according to the present invention, the azeotropic agent is a hydrocarbon having a boiling point of 60 °C to 120 °C. For example, the azeotrope may be alcohol, preferably ethanol.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 단계 (b)는 100 kPa 내지 200 kPa의 압력 하에 수행되는 것을 특징으로 한다. In the separation method of ginseng free water according to the present invention, the step (b) is characterized in that it is performed under a pressure of 100 kPa to 200 kPa.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 단계 (c)는 35 ℃ 내지 45 ℃의 온도에서 수행되는 것을 특징으로 한다. In the separation method of ginseng free water according to the present invention, the step (c) is characterized in that it is carried out at a temperature of 35 ℃ to 45 ℃.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 단계 (d)는 -30 ℃ 내지 -50 ℃의 온도에서 수행되는 것을 특징으로 한다. In the separation method of ginseng free water according to the present invention, the step (d) is characterized in that it is carried out at a temperature of -30 ℃ to -50 ℃.
본 발명에 따른 인삼 자유수의 분리 방법에 있어서, 상기 인삼 자유수는 항균용 조성물, 방부용 조성물, 항산화 조성물, 항염증 조성물, 피부 상태 개선용 조성물, 항알레르기 조성물, 항비만 조성물, 탈모방지 또는 육모촉진 조성물 및 자극완화용 조성물로 사용되는 것을 특징으로 한다. In the separation method of ginseng free water according to the present invention, the free ginseng water is an antibacterial composition, antiseptic composition, antioxidant composition, anti-inflammatory composition, skin condition improvement composition, anti-allergic composition, anti-obesity composition, hair loss prevention or It is characterized in that it is used as a composition for promoting hair growth and for alleviating irritation.
2. 인삼 자유수의 분리 장치2. Separation device of ginseng free water
본 발명은 공비증류를 이용한 인삼 자유수의 분리 장치를 제공하고자 하는 것으로, 상기 분리 장치는:The present invention is to provide a separation device for ginseng free water using azeotropic distillation, the separation device comprising:
수삼과 공비제를 포함하는 건조기(100),
상기 건조기와 연결되어 건조기 내부를 가열하는 히터(110),a
상기 건조기 내부와 연결되는 감압기(120),a pressure reducer 120 connected to the inside of the dryer;
상기 감압기와 연결되어 기체화된 인삼 자유수를 응축시키는 응축기(130),A
상기 응축기와 연결되어 공비제를 응축시키는 저온 응축기(140),A low-
상기 응축기와 연결되어 인삼 자유수를 회수하는 저장 탱크(150), 및A
상기 저온 응축기와 연결되어 공비제를 회수하는 회수탱크(160)을 포함하는 것을 특징으로 한다. It is characterized in that it includes a
본 발명에 따른 인삼 자유수의 분리 장치에 있어서, 상기 수삼과 공비제의 중량비는 5:1 내지 15:1, 바람직하기는 10:1인 것을 특징으로 한다. In the apparatus for separating ginseng free water according to the present invention, the weight ratio of the fresh ginseng and the azeotrope is 5:1 to 15:1, preferably 10:1.
본 발명에 따른 인삼 자유수의 분리 장치에 있어서, 상기 공비제는 끓는점이 60 ℃ 내지 120 ℃인 탄화수소인 것을 특징으로 한다. 예를 들면, 상기 공비제는 알코올, 바람직하기는 에탄올일 수 있다. In the apparatus for separating ginseng free water according to the present invention, the azeotropic agent is a hydrocarbon having a boiling point of 60 °C to 120 °C. For example, the azeotrope may be alcohol, preferably ethanol.
본 발명에 따른 인삼 자유수의 분리 장치에 있어서, 상기 감압기(120)내 진공 압력은 100 kPa 내지 200 kPa인 것을 특징으로 한다. In the apparatus for separating ginseng free water according to the present invention, the vacuum pressure in the
본 발명에 따른 인삼 자유수의 분리 장치에 있어서, 상기 응축기(130)내 온도는 35 ℃ 내지 45 ℃인 것을 특징으로 한다. In the separation device of ginseng free water according to the present invention, the temperature in the
본 발명에 따른 인삼 자유수의 분리 장치에 있어서, 상기 저온 응축기(140)내 온도는 -30 ℃ 내지 -50 ℃인 것을 특징으로 한다. In the separation device of ginseng free water according to the present invention, the temperature in the low-
3. 인삼 자유수의 용도3. Uses of ginseng free water
본 발명은 공비증류를 이용하여 분리된 인삼 자유수의 용도를 제공하고자 한다. The present invention is to provide the use of ginseng free water separated using azeotropic distillation.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 항균용 조성물로 사용되는 것을 특징으로 한다. 상기 인삼 자유수는 조성물은 스트렙토코쿠스 종(Streptococcus spp.), 살모넬라 종(Salmonella spp.), 에스케리치아 종(Escherichia spp.), 스타필로코쿠스 종(Staphylococcus spp.), 쉬젤라 종(Shigella spp.), 슈도모나스 종(Pseudomonas spp.), 리스테리아 종(Listeria spp.), 비브리오 종(Vibrio spp.), 바실러스 종(Bacillus spp.), 프로피오니박테리움 종(Propionibacterium spp.), 캄필로박터 종(Campylobacter spp.), 헬리코박터 종(Helicobacter spp.), 클로스트리디움 종(Clostridium spp.), 보르데텔라 종(Bordetella spp.), 예르시니아 종(Yersinia spp.), 레지오넬라 종(Legionella spp.), 에어로모나스 종(Aeromonas spp.), 박테로데스 종(Bacteroides spp.), 네이세리아 종(Neisseria spp.), 모락셀라 종(Moraxella spp.), 코리네박테리움 종(Corynebacterium spp.) 및 악티노바실러스 종(Actinobacilluss spp.)으로 구성된 군으로부터 선택되는 하나 이상의 미생물에 대하여 항균 활성을 나타낼 수 있다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as an antibacterial composition. The composition of the ginseng free water is Streptococcus spp. , Salmonella spp. , Escherichia spp. , Staphylococcus spp. , Shigella species ( Shigella spp. ), Pseudomonas spp. , Listeria spp. , Vibrio spp. , Bacillus spp. , Propionibacterium spp. , Campylo. bakteo species (Campylobacter spp.), Helicobacter species (Helicobacter spp.), Clostridium species (Clostridium spp.), Bordetella species (Bordetella spp.), Yersinia species (Yersinia spp.), Legionella species (Legionella spp. ), Aeromonas species ( Aeromonas spp. ), Bacteroides spp. ), Neisseria species ( Neisseria spp. ), Moraxella species ( Moraxella spp. ), Corynebacterium spp. ) and Actinobacillus species ( Actinobacillus s spp. ) It may exhibit antibacterial activity against one or more microorganisms selected from the group consisting of.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 방부용 조성물로 사용되는 것을 특징으로 한다. 상기 인삼 자유수는 이스케리치아 종, 슈도모나스 종 및 스태필로코쿠스로 구성된 군으로부터 선택되는 하나 이상의 미생물에 대해 방부 효과를 나타낼 수 있다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as an antiseptic composition. The ginseng free water may exhibit an antiseptic effect against one or more microorganisms selected from the group consisting of Ischerichia species, Pseudomonas species and Staphylococcus.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 항산화 조성물로 사용되는 것을 특징으로 한다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as an antioxidant composition.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 항염증 조성물로 사용되는 것을 특징으로 한다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as an anti-inflammatory composition.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 피부 상태 개선용 조성물로 사용되는 것을 특징으로 한다. 상기 피부 상태 개선은 미백, 피부탄력도의 증가, 콜라겐 합성 촉진 또는 콜라게네이즈 억제를 포함할 수 있다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as a composition for improving skin condition. The improvement of the skin condition may include whitening, increase of skin elasticity, promotion of collagen synthesis, or inhibition of collagenase.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 항알레르기 조성물로 사용되는 것을 특징으로 한다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as an anti-allergic composition.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 항비만 조성물로 사용되는 것을 특징으로 한다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as an anti-obesity composition.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 탈모방지 또는 육모촉진 조성물로 사용되는 것을 특징으로 한다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as a hair loss prevention or hair growth promoting composition.
본 발명에 따른 공비증류를 이용하여 분리된 인삼 자유수는 자극완화용 조성물로 사용되는 것을 특징으로 한다. Ginseng free water separated using azeotropic distillation according to the present invention is characterized in that it is used as a composition for alleviating irritation.
(1) 화장료 조성물(1) cosmetic composition
본 발명은 공비증류를 이용하여 분리된 인삼 자유수를 유효성분 포함하는 항균용 조성물, 방부용 조성물, 항산화 조성물, 항염증 조성물, 피부 상태 개선용 조성물, 항알레르기 조성물, 항비만 조성물, 탈모방지 또는 육모촉진 조성물 및 자극완화용 조성물로서 화장료 조성물을 제공하고자 한다. The present invention provides an antibacterial composition, antiseptic composition, antioxidant composition, anti-inflammatory composition, skin condition improvement composition, anti-allergic composition, anti-obesity composition, hair loss prevention or An object of the present invention is to provide a cosmetic composition as a composition for promoting hair growth and for alleviating irritation.
본 발명에 따른 화장료 조성물에 포함되는 성분은 유효 성분으로서의 인삼 자유수 이외에 화장료 조성물에 통상적으로 이용되는 성분들을 포함하며, 예를 들면 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함한다.The ingredients included in the cosmetic composition according to the present invention include ingredients commonly used in cosmetic compositions in addition to ginseng free water as an active ingredient, for example, conventional adjuvants such as stabilizers, solubilizers, vitamins, pigments and fragrances; and carriers.
본 발명에 따른 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들면, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이 등으로 제형화될 수 있으나, 이에 한정되는 것은 아니다. 보다 상세하게는, 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형으로 제조될 수 있다.The cosmetic composition according to the present invention may be prepared in any formulation conventionally prepared in the art, for example, a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing It may be formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, a nourishing lotion, a nourishing cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, or a powder.
본 발명에 따른 화장료 조성물의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the cosmetic composition according to the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component etc. may be used.
본 발명에 따른 화장료 조성물의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the cosmetic composition according to the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluoro propellants such as hydrocarbons, propane/butane or dimethyl ether.
본 발명에 따른 화장료 조성물의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예를 들면 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the cosmetic composition according to the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzo acid, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic esters, fatty acid esters of polyethylene glycol or sorbitan.
본 발명에 따른 화장료 조성물의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the cosmetic composition according to the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, such as suspension agent, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like can be used.
본 발명에 따른 화장료 조성물의 제형이 계면-활성제 함유 클린징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the cosmetic composition according to the present invention is surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcocy nate, fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester and the like can be used.
(2) 식품 조성물(2) food composition
본 발명은 공비증류를 이용하여 분리된 인삼 자유수를 유효성분 포함하는 항균용 조성물, 방부용 조성물, 항산화 조성물, 항염증 조성물, 피부 상태 개선용 조성물, 항알레르기 조성물, 항비만 조성물, 탈모방지 또는 육모촉진 조성물 및 자극완화용 조성물로서 식품 조성물을 제공하고자 한다. The present invention provides an antibacterial composition, antiseptic composition, antioxidant composition, anti-inflammatory composition, skin condition improvement composition, anti-allergic composition, anti-obesity composition, hair loss prevention or An object of the present invention is to provide a food composition as a composition for promoting hair growth and for alleviating irritation.
본 발명에 따른 식품 조성물은 유효성분으로서 인삼 자유수 뿐만 아니라, 식품 제조 시에 통상적으로 첨가되는 성분을 포함할 수 있으며, 예를 들면, 단백질, 탄수화물, 지방, 영양소, 조미제 및 향미제를 포함한다. 상술한 탄수화물의 예는 모노사카라이드, 예를 들면, 포도당, 과당 등; 디사카라이드, 예를 들어 말토스, 슈크로스, 올리고당 등; 및 폴리사카라이드, 예를 들면 덱스트린, 사이클로덱스트린 등과 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 향미제로서 천연 향미제 [타우마틴, 스테비아 추출물 (예를 들면 레바우디오시드 A, 글리시르히진 등]) 및 합성 향미제(사카린, 아스파르탐 등)를 사용할 수 있다. 예를 들면 , 본 발명의 식품 조성물이 드링크제로 제조되는 경우에는 본 발명의 인삼 자유수 이외에 구연산, 액상과당, 설탕, 포도당, 초산, 사과산, 과즙, 두충 추출액, 대추 추출액, 감초 추출액 등을 추가로 포함시킬 수 있다.The food composition according to the present invention may include not only ginseng free water as an active ingredient, but also ingredients commonly added during food production, for example, including protein, carbohydrate, fat, nutrients, seasonings and flavoring agents. do. Examples of the above-mentioned carbohydrates include monosaccharides such as glucose, fructose and the like; disaccharides such as maltose, sucrose, oligosaccharides and the like; and polysaccharides such as conventional sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents, natural flavoring agents [taumatine, stevia extract (eg, rebaudioside A, glycyrrhizin, etc.)) and synthetic flavoring agents (saccharin, aspartame, etc.) can be used. For example, when the food composition of the present invention is prepared as a drink, in addition to the ginseng free water of the present invention, citric acid, fructose, sugar, glucose, acetic acid, malic acid, fruit juice, licorice root extract, jujube extract, licorice extract, etc. are additionally added. can be included
(3) 약제학적 조성물(3) pharmaceutical composition
본 발명은 공비증류를 이용하여 분리된 인삼 자유수를 유효성분 포함하는 항균용 조성물, 방부용 조성물, 항산화 조성물, 항염증 조성물, 피부 상태 개선용 조성물, 항알레르기 조성물, 항비만 조성물, 탈모방지 또는 육모촉진 조성물 및 자극완화용 조성물로서 약제학적 조성물을 제공하고자 한다. The present invention provides an antibacterial composition, antiseptic composition, antioxidant composition, anti-inflammatory composition, skin condition improvement composition, anti-allergic composition, anti-obesity composition, hair loss prevention or An object of the present invention is to provide a pharmaceutical composition as a composition for promoting hair growth and for alleviating irritation.
본 발명에 따른 약제학적 조성물은 약제학적으로 허용되는 담체를 포함할 수 있으며, 예컨대, 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산 칼슘, 알기네이트, 젤라틴, 규산 칼슘, 미세결정성 셀룰로스, 폴리비닐피롤리돈, 셀룰로스, 물, 시럽, 메틸 셀룰로스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘 및/또는 미네랄 오일을 포함할 수 있다. 본 발명의 약제학적 조성물은 상기 성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다. 적합한 약제학적으로 허용되는 담체 및 제제는 Remington's Pharmaceutical Sciences (19th ed., 1995)에 상세히 기재되어 있다.The pharmaceutical composition according to the present invention may contain a pharmaceutically acceptable carrier, for example, lactose, dextrose, sucrose, sorbitol, mannitol, starch, gum acacia, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and/or mineral oil. The pharmaceutical composition of the present invention may further include a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, and the like, in addition to the above components. Suitable pharmaceutically acceptable carriers and agents are described in detail in Remington's Pharmaceutical Sciences (19th ed., 1995).
본 발명에 따른 약제학적 조성물의 적합한 투여량은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성, 병적 상태, 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하게 처방될 수 있다. 한편, 본 발명의 약제학적 조성물의 피부국소 투여량은 바람직하게는 1일 당 0.001-100000 ㎎/㎏이다.A suitable dosage of the pharmaceutical composition according to the present invention may vary depending on factors such as formulation method, administration method, patient's age, weight, sex, morbidity, food, administration time, administration route, excretion rate, and response sensitivity. can be prescribed. On the other hand, the skin topical dosage of the pharmaceutical composition of the present invention is preferably 0.001-100000 mg/kg per day.
본 발명에 따른 약제학적 조성물은 당해 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라, 약제학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화함으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수 있다.The pharmaceutical composition according to the present invention is formulated in a unit dosage form by using a pharmaceutically acceptable carrier and/or excipient according to a method that can be easily carried out by a person of ordinary skill in the art to which the present invention pertains. It may be prepared or prepared by inclusion in a multi-dose container.
도 1은 본 발명에 따른 인삼 자유수의 분리 장치를 나타낸다.
도 2는 실시예 1에 따른 공비증류를 이용한 인삼 자유수의 분리 효율을 나타낸다.
도 3은 실시예 3에 따른 공비증류를 이용하여 분리된 인삼 자유수의 항산화 효과를 나타낸다. 1 shows an apparatus for separating ginseng free water according to the present invention.
Figure 2 shows the separation efficiency of ginseng free water using azeotropic distillation according to Example 1.
3 shows the antioxidant effect of ginseng free water separated using azeotropic distillation according to Example 3.
이하, 발명의 이해를 돕기 위해 다양한 실시예를 제시한다. 하기 실시예는 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐 발명의 보호범위가 하기 실시예에 한정되는 것은 아니다.Hereinafter, various examples are presented to help the understanding of the invention. The following examples are provided for easier understanding of the invention, and the protection scope of the invention is not limited to the following examples.
<실시예><Example>
실시예 1 : 공비증류를 이용한 인삼 자유수의 분리 효율Example 1: Separation efficiency of ginseng free water using azeotropic distillation
(1) 공비 증류를 통한 인삼 자유수의 제조(제조예 1)(1) Preparation of ginseng free water through azeotropic distillation (Preparation Example 1)
수삼 200g을 건조기(100)에 넣고 에탄올을 20g을 혼합하여 인삼 자유수를 제조하였다. 진공 압력은 100kPa, 가열온도는 40 ℃로 설정하고 저온 응축기(140)의 온도는 -40 ℃를 유지하여 에탄올을 포집하고 인삼 자유수는 응축기(130)에서 1~5시간 동안 응축하며 분리 효율을 확인하였다. 200 g of fresh ginseng was placed in a
(2) 종래의 응축을 통한 인삼 자유수의 제조(제조예 2)(2) Preparation of ginseng free water through conventional condensation (Preparation Example 2)
저온 응축기(140)가 제거된 상태에서 수삼 200g 을 건조기(100)에 넣고 진공 농축을 통해 인삼 자유수를 제조 하였다. 진공 압력은 100kPa, 가열온도는 40 ℃ 로 설정한 후 1~5시간 동안 응축하며 분리 효율을 확인 하였다. In a state in which the low-
(3) 결과(3) Results
상기 공비 증류 및 응축을 통해 분리된 인삼 자유수 수득 누적량 및 수득 누적율을 하기의 표 1에 나타내었다. The accumulated amount and the obtained accumulation rate of free ginseng free water separated through the azeotropic distillation and condensation are shown in Table 1 below.
[표 1][Table 1]
상기 표 1로부터 알 수 있듯이, 본 발명에 따른 공비증류에 의해 인삼 자유수를 분리하는 경우 종래의 일반 응축법에 비하여 빠른 시간에 효율적으로 인삼 자유수를 분리할 수 있음이 확인되었다(도 2). As can be seen from Table 1, when the free ginseng water is separated by azeotropic distillation according to the present invention, it was confirmed that the free ginseng water can be efficiently separated in a faster time than the conventional general condensation method (FIG. 2). .
실시예 2 : 공비증류에 의해 인삼 자유수의 분리에 따른 인삼의 성분 변화 확인Example 2: Confirmation of change in composition of ginseng according to separation of ginseng free water by azeotropic distillation
(1) 인삼 자유수 제거후 추가 건조를 통해 얻어진 인삼 건조물의 추출물 제조(제조예 3)(1) Preparation of extract of dried ginseng obtained through additional drying after removal of ginseng free water (Preparation Example 3)
상기 실시예 1에 따라 공비증류에 의해 인삼 자유수가 제거된 인삼을 건조 오븐에서 60℃에서 24시간 건조시킨후 분쇄기로 파쇄한 후 파쇄물 10g 과 70% 에탄올 수용액 50g을 혼합하여 2시간 동안 추출하여 제조하였다.According to Example 1, after drying ginseng from which free ginseng water has been removed by azeotropic distillation in a drying oven at 60° C. for 24 hours, crushed with a grinder, 10 g of the crushed product and 50 g of a 70% aqueous ethanol solution are mixed and extracted for 2 hours. did.
(2) 일반 건조 방법을 통한 인삼 건조후 추출물의 제조(제조예 4)(2) Preparation of extract after drying of ginseng through a general drying method (Preparation Example 4)
수삼 200g 을 일반 건조 오븐에서 60℃에서 24시간 건조시킨후 분쇄기로 파쇄한 후 파쇄물 10g 과 70% 에탄올 수용액 50g을 혼합하여 2시간 동안 추출하여 제조하였다.200 g of fresh ginseng was dried in a general drying oven at 60° C. for 24 hours, crushed with a grinder, 10 g of the crushed product and 50 g of a 70% aqueous ethanol solution were mixed, and extracted for 2 hours.
(3) 진세노사이드 함량 비교(3) Comparison of ginsenoside content
상기 건조된 인삼의 추출물 내 주요 진세노사이드 함량을 확인하고 그 결과를 하기의 표 2에 나타내었다. The main ginsenoside content in the dried ginseng extract was confirmed and the results are shown in Table 2 below.
[표 2][Table 2]
상기 표 2로부터 알 수 있듯이, 공비 증류법을 통해 인삼 자유수를 분리하더라도 원래의 인삼에 있는 주요 성분인 진세노사이드의 함량은 변화가 크지 않은 것으로 확인되었다. As can be seen from Table 2, it was confirmed that the content of ginsenoside, which is the main component in the original ginseng, did not change much even if the free ginseng water was separated through the azeotropic distillation method.
실시예 3 : 공비증류에 의해 분리된 인삼 자유수의 항산화 효과 확인Example 3: Confirmation of antioxidant effect of ginseng free water separated by azeotropic distillation
상기 실시예 1에서 공비증류에 의해 분리된 인삼 자유수의 항산화 효과를 확인하기 위하여 ABTS (2,2-Azino-bis(3-ethylbensothiazoline-6-sulfonic acid) assay를 수행하였다. 증류수를 용매로 하여 7.4 mM ABTS 용액과 2.45 mM potassium persulfate용액을 준비한 뒤, 시약을 질량비 1:1로 혼합하고 암소에서 24시간 보관하여 ABTS radical을 형성시켰다. L-ascorbic aicd는 농도가 25, 50, 100, 200 ppm이 되도록 준비하고 시험할 시료는 50배로 희석하여 준비하였다. 실험하기 전, 암소에서 24시간 방치한 ABTS radical 용액 5 mL을 증류수 95 mL로 희석하고 시험할 시료 및 양성대조군을 10 μL씩 96-well plate에 넣었다. 희석한 ABTS radical 용액을 190 μL씩 넣어주고 control 군에는 동일한 양의 증류수를 넣어주었다. 해당 96-well plate는 실온, 암소에서 10분간 반응시키고 microplate reader를 이용하여 UV 730 nm애서 흡광도를 측정하였다. ABTS 자유 라디칼 소거 활성은 하기의 화학식 1에 따라 계산하고, 그 결과를 도 3에 나타내었다. ABTS (2,2-Azino-bis(3-ethylbensothiazoline-6-sulfonic acid) assay was performed to confirm the antioxidant effect of free ginseng water separated by azeotropic distillation in Example 1. Using distilled water as a solvent After preparing a 7.4 mM ABTS solution and a 2.45 mM potassium persulfate solution, the reagents were mixed in a mass ratio of 1:1 and stored in a dark place for 24 hours to form ABTS radicals. Before the experiment, 5 mL of the ABTS radical solution left in the dark for 24 hours was diluted with 95 mL of distilled water, and the sample to be tested and the positive control group were prepared by diluting 50 times. 190 μL of diluted ABTS radical solution was added and the same amount of distilled water was added to the control group. The 96-well plate was reacted for 10 minutes at room temperature and in the dark, and absorbance at UV 730 nm using a microplate reader. ABTS free radical scavenging activity was calculated according to Formula 1 below, and the results are shown in FIG.
ABTS 자유 라디칼 소거능(%) = (1-A/B) × 100ABTS free radical scavenging capacity (%) = (1-A/B) × 100
(A: 시험할 시료의 흡광도 변화; B: 시료를 넣지 않은 control군의 흡광도 변화)(A: Change in absorbance of the sample to be tested; B: Change in absorbance in the control group without sample)
도 3으로부터 알 수 있듯이, 본 발명에 따른 공비증류에 의해 분리된 인삼 자유수는 추가 농축 없이 그대로 사용하더라도 L-ascorbic acid 10ppm 수준의 항산화 효과를 가지는 것으로 확인되었다. As can be seen from FIG. 3, it was confirmed that the free ginseng water separated by azeotropic distillation according to the present invention had an antioxidant effect of 10 ppm level of L-ascorbic acid even when used as it is without additional concentration.
이상으로 본 발명의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.As described above in detail a specific part of the present invention, for those of ordinary skill in the art, this specific description is only a preferred embodiment, and it is clear that the scope of the present invention is not limited thereto. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.
100 건조기
110 히터
120 감압기
130 응축기
140 저온 응축기
150 저장 탱크
160 회수 탱크100 dryer
110 heater
120 pressure reducer
130 condenser
140 low temperature condenser
150 storage tank
160 recovery tank
Claims (13)
(b) 상기 수삼과 공비제 혼합물을 감압조건에서 증류하는 단계;
(c) 상기 증류 중 발생하는 기체화된 인삼 자유수를 35 내지 45 ℃에서 응축시켜 회수하는 단계; 및
(d) 상기 공비제를 - 30 내지 - 50 ℃에서 저온 응축시켜 회수하는 단계를 포함하는,
공비증류를 이용한 인삼 자유수의 분리 방법.
(a) heating a mixture of fresh ginseng and an azeotrope obtained by mixing fresh ginseng and an azeotrope in a weight ratio of 5:1 to 15:1;
(b) distilling the fresh ginseng and azeotrope mixture under reduced pressure;
(c) condensing and recovering the vaporized free ginseng free water generated during the distillation at 35 to 45 ℃; and
(d) recovering the azeotrope by condensing it at a low temperature at -30 to -50 °C,
Separation method of ginseng free water using azeotropic distillation.
상기 공비제는 끓는점이 60 ℃ 내지 120 ℃인 탄화수소인 것을 특징으로 하는 것인, 공비증류를 이용한 인삼 자유수의 분리 방법.
According to claim 1,
The azeotropic agent is a method for separating ginseng free water using azeotropic distillation, characterized in that the hydrocarbon has a boiling point of 60 ℃ to 120 ℃.
상기 단계 (b)는 100 kPa 내지 200 kPa의 압력 하에 수행되는 것을 특징으로 하는 것인, 공비증류를 이용한 인삼 자유수의 분리 방법.
According to claim 1,
The step (b) is a method for separating ginseng free water using azeotropic distillation, characterized in that it is carried out under a pressure of 100 kPa to 200 kPa.
상기 인삼 자유수는 항균용 조성물, 방부용 조성물, 항산화 조성물, 항염증 조성물, 피부 상태 개선용 조성물, 항알레르기 조성물, 항비만 조성물, 탈모방지 또는 육모촉진 조성물 및 자극완화용 조성물로 사용되는 것을 특징으로 하는 것인, 공비증류를 이용한 인삼 자유수의 분리 방법.
According to claim 1,
The ginseng free water is used as an antibacterial composition, an antiseptic composition, an antioxidant composition, an anti-inflammatory composition, a skin condition improvement composition, an anti-allergic composition, an anti-obesity composition, a hair loss prevention or hair growth promoting composition, and a composition for alleviating irritation A method of separating ginseng free water using azeotropic distillation.
A cosmetic composition comprising, as an active ingredient, ginseng free water separated according to any one of claims 1, 3, 4 and 6.
A food composition comprising free ginseng water separated according to any one of claims 1, 3, 4 and 6 as an active ingredient.
A pharmaceutical composition comprising the free ginseng water separated according to any one of claims 1, 3, 4 and 6 as an active ingredient.
상기 건조기와 연결되어 건조기 내부를 가열하는 히터(110),
상기 건조기 내부와 연결되는 감압기(120),
상기 감압기와 연결되어 기체화된 인삼 자유수를 35 내지 45 ℃에서 응축시키는 응축기(130),
상기 응축기와 연결되어 공비제를 - 30 내지 - 50 ℃에서 응축시키는 저온 응축기(140),
상기 응축기와 연결되어 인삼 자유수를 회수하는 저장 탱크(150), 및
상기 저온 응축기와 연결되어 공비제를 회수하는 회수탱크(160)을 포함하는,
공비증류를 이용한 인삼 자유수의 분리 장치.
Dryer 100 containing fresh ginseng and azeotrope in a weight ratio of 5:1 to 15:1,
A heater 110 connected to the dryer to heat the inside of the dryer;
a pressure reducer 120 connected to the inside of the dryer;
A condenser 130 connected to the pressure reducer to condense the vaporized free water of ginseng at 35 to 45 ℃,
A low-temperature condenser 140 that is connected to the condenser to condense the azeotrope at -30 to -50 ℃,
A storage tank 150 connected to the condenser to recover ginseng free water, and
and a recovery tank 160 connected to the low-temperature condenser to recover the azeotropic agent,
Separation device of ginseng free water using azeotropic distillation.
상기 감압기(120)내 진공 압력은 100 kPa 내지 200 kPa인 것을 특징으로 하는 것인, 공비증류를 이용한 인삼 자유수의 분리 장치.
11. The method of claim 10,
The vacuum pressure in the pressure reducer 120 is 100 kPa to 200 kPa, characterized in that, azeotropic distillation using ginseng free water separation device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200011167A KR102296426B1 (en) | 2020-01-30 | 2020-01-30 | Method and apparatus for separating ginseng free water using azeotropic distillation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200011167A KR102296426B1 (en) | 2020-01-30 | 2020-01-30 | Method and apparatus for separating ginseng free water using azeotropic distillation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210097451A KR20210097451A (en) | 2021-08-09 |
| KR102296426B1 true KR102296426B1 (en) | 2021-09-01 |
Family
ID=77313432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020200011167A KR102296426B1 (en) | 2020-01-30 | 2020-01-30 | Method and apparatus for separating ginseng free water using azeotropic distillation |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR102296426B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008043840A (en) | 2006-08-11 | 2008-02-28 | Tetsuro Asao | Method for extracting effective component |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101102480B1 (en) * | 2004-04-27 | 2012-01-05 | 노부유키 하야시 | Extraction method using pressurized heating medium and device |
| KR101727721B1 (en) * | 2015-08-12 | 2017-04-17 | 이영주 | How to extract the fluid component from the evaporation plant and equipment and an extract |
| KR101950341B1 (en) * | 2016-08-31 | 2019-02-21 | 영동건강 주식회사 | Adsorbent prepared from a shiitake, and the method for obtaining a fraction containing a high concentration of ginsenoside Rg3 using the same |
| KR102031750B1 (en) * | 2017-12-14 | 2019-10-14 | (주)진셀팜 | A cosmetic composition comprising violaxanthin |
-
2020
- 2020-01-30 KR KR1020200011167A patent/KR102296426B1/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008043840A (en) | 2006-08-11 | 2008-02-28 | Tetsuro Asao | Method for extracting effective component |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210097451A (en) | 2021-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005506948A (en) | Method for obtaining polyphenol extract from cocoa beans, obtained extract and use thereof | |
| KR101332803B1 (en) | Method for Preparing Supercritical Fluid Extract of Cinnamomum verum and Its Use | |
| KR930010548B1 (en) | Whitening Cosmetics Containing Mt. Extract | |
| KR100851489B1 (en) | Cosmetic composition containing tilianin or acacetin | |
| KR102296426B1 (en) | Method and apparatus for separating ginseng free water using azeotropic distillation | |
| US2971844A (en) | Method for preparing linden blossom tea concentrate | |
| KR102034844B1 (en) | Compositions for Anti-Bacterial and Anti-Inflammatory Effect Comprising Callus Extract of Hibiscus Syriacus | |
| JPH10226633A (en) | Cosmetic composition containing extract of chestnut bur | |
| CN106726867A (en) | A kind of application of the extracting method and the extract of lime tree flower extract | |
| KR101958454B1 (en) | Composition for blocking AGEs production and promoting AGEs decomposition comprising defatted Torreya nucifera's seed extract | |
| KR102686811B1 (en) | Purification method of p-coumaric acid from bamboo leaf and Cosmetic composition containing purified p-coumaric acid | |
| JP2023111879A (en) | Method for producing purified lemon balm extract | |
| US4132782A (en) | Method for suppressing herpes simplex virus | |
| KR102503521B1 (en) | Method for producing centella asiatica extract using liquid nitrogen and centella asiatica extract produced thereby | |
| KR102625741B1 (en) | Cosmetic composition for moisturizing skin comprising mixed extracts of capparis spinosa, olea europaea, citrus sinensis and oryza sativa | |
| KR102346411B1 (en) | Manufacturing Method For Cosmetic Composition Comprising the Extract of Abelliophyllum distichum as active Ingredient | |
| KR102728256B1 (en) | Extraction method of natural products using hot water extraction using distilled extract as an extraction solvent | |
| KR102334192B1 (en) | Functional cosmetic composition comprising korean dandelion | |
| KR101460466B1 (en) | Composition for Preventing or Treating of Diabetes or Obesity Comprising Pteridophyta Extracts as Active Ingredients | |
| KR20200038720A (en) | Anti-oxidant composition comprising the flower apple extract as an effective component | |
| KR102322974B1 (en) | Compositions for Improving Skin Wrinkles Using an Extract of Boehmeria tricuspis var. unicuspis | |
| KR20050120880A (en) | Cosmetic composition having skin-irritation reducing effect and containing morinda citrifolia extract | |
| KR102177138B1 (en) | Cosmetic Composition Contaning Mixed Extract Of Selaginella Tamariscina, Pyrus Malus, Cucumis Sativus And Scutellaia baicalensis For Moisturizing | |
| KR100816264B1 (en) | Cosmetic composition for alleviating skin irritation containing throat extract as an active ingredient | |
| KR20220076751A (en) | Anti-oxidant composition comprising the extract of flower apple skk14 as an effective component |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 20200130 |
|
| PA0201 | Request for examination | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20210222 Patent event code: PE09021S01D |
|
| PG1501 | Laying open of application | ||
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20210823 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20210826 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20210827 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| PR1001 | Payment of annual fee |
Payment date: 20240627 Start annual number: 4 End annual number: 4 |