KR102274607B1 - Clear Aqueous Ceramide Composition and Cosmetic and Pharmaceutical Products Containing the Same - Google Patents

Abstract

The present invention relates to a novel ceramide micro aqueous dispersion composition and cosmetics and pharmaceuticals containing the same. The transparent ceramide aqueous dispersion composition of the present invention is excellent in stability over time and is a cosmetic and pharmaceutical raw material excellent in function, texture, and appearance.

Description

Clear Aqueous Ceramide Composition and Cosmetic and Pharmaceutical Products Containing the Same

The present invention relates to a ceramide micro-aqueous dispersion composition that is excellent in stability over time and is also excellent in function, feel, and appearance.

More particularly, the present invention relates to cosmetics and pharmaceuticals containing the novel ceramide micro aqueous dispersion composition.

Ceramide exists in the stratum corneum of the skin and plays an important role in maintaining moisture by building a lipid barrier necessary for moisture retention. For this reason, several attempts have been made to make a mixed cosmetic containing ceramides intended to retain moisture by applying it to the skin. However, ceramide is a material with high crystallinity, low solubility, and it was difficult to secure stability over time in cosmetics, such as crystals precipitated at a low temperature. In particular, it was very difficult to obtain a transparent raw material stably solubilizing ceramide in a cosmetic with a high moisture content.

In addition, there are many types of cosmetics applied to the skin, but among them, a transparent formulation is important for product selectivity, and it has been considered that a raw material with excellent stability in which ceramides are solubilized is desirable. However, because of the low solubility of ceramides, it is difficult to obtain a transparent composition stably dissolved in water alone, so it is necessary to mix a solubilizer such as a surfactant. In order to obtain a transparent raw material in which ceramides are solubilized with the existing technology, it is necessary to increase the blending amount of the solubilizer, which may impair stability and feeling of use.

On the other hand, if the amount of surfactant is reduced, cloudy or translucent turbidity occurs, so ceramides cannot be sufficiently solubilized, and it is difficult to secure stability over time, such as sediment and oily layer.

As a method of improving the difficulty of ceramide solubilization, a nonionic surfactant with an HLB of 9-20 (PEG-6 hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene copolymer) , polyoxyethylene phytosterol, polyoxyethylene phytostanol, polyoxyethylene cholestanol, polyoxyethylene lauryl ether) and a liquid polyalcohol are disclosed (Patent Document 1: JP 2002-338459 A) . However, in the case of the composition, the transparency can only last up to 1 to 2 months, and considering that the shelf life of medicines and cosmetics is 6 months or more, there is still a need for a transparent raw material in which ceramide is solubilized more stably for a long time.

Numerous references are referenced throughout this specification and citations thereof are indicated. The disclosures of the cited documents are incorporated herein by reference in their entirety to more clearly describe the content of the present invention and the level of the art to which the present invention pertains.

Japanese Patent Laid-Open No. 2002-338459

The present inventors have found that when an amphoteric surfactant is mainly used as a method for producing a ceramide fine aqueous dispersion, transparent stability can be maintained continuously even for a long time of 6 months or more, and through this, A novel ceramide micro-aqueous dispersion composition has been developed as a raw material for pharmaceuticals and cosmetics with excellent stability and excellent function, texture, and appearance.

Accordingly, an object of the present invention is to provide a ceramide transparent aqueous dispersion composition mainly using an amphoteric surfactant.

Another object of the present invention is to provide cosmetics and pharmaceuticals comprising the novel ceramide micro aqueous dispersion composition.

Further objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

One aspect of the present invention is a transparent aqueous dispersion composition comprising 0.01 to 5.0 wt% of a ceramide, 0.1 to 70 wt% of a surfactant, and 0.1 to 40 wt% of a water-soluble solvent, wherein the surfactant is essentially an amphoteric surfactant It is to provide a transparent aqueous dispersion composition, characterized in that the content is 50% by weight or more of the total surfactant.

When ceramide and cholesterol are finely dispersed, it penetrates into the skin and hair and maintains it in a healthy state. However, ceramide has a high melting point and is easy to crystallize. Since a large amount of surfactant is required for stable microdispersion, the function and texture of pharmaceuticals are impaired.

The present invention provides a transparent aqueous dispersion that is microscopically stable over a long period of time using a small amount of ceramide as a surfactant, and the average particle diameter of the ceramide-containing particles may be 1 to 200 nm.

The ceramide is ceramide 1 (ceramide EOS), ceramide 2 (ceramide NS), ceramide 3 (ceramide NP), ceramide 4 (ceramide EOH), ceramide 5 (ceramide AS), ceramide 6 (ceramide NH), ceramide 7 (ceramide AP) ), ceramide 8 (ceramide AH) and ceramide 9 (ceramide EOP) may be one or more selected from the group consisting of, but is not limited thereto.

The surfactant mainly uses an amphoteric surfactant, and various other hydrophilic surfactants may be used in combination. The amount of the amphoteric surfactant in the surfactant is 50% or more, preferably 55% or more.

As the hydrophilic surfactant, various cationic surfactants, anionic surfactants and nonionic surfactants that can be used in cosmetics and pharmaceuticals may be used.

The amount of amphoteric surfactant used depends on the type and amount of oily components because ceramide has a high melting point and is easy to crystallize. Therefore, the amount of surfactant may be used as surfactant/(ceramides + oily component) = 5 to 100, preferably 10 to 100, based on the weight of each component, but is not necessarily limited thereto.

Amphoteric surfactants include cocamidopropylbetaine, isostearamidopropylbetaine, alkylbetaine, N-lauroyl-N-carboxymethyl-N-hydroxyethylethylenediamine, hydroxyalkyl (C12-14 ) Hydroxyethyl sarcosine, lauryl hydroxy sultaine, etc. are mentioned. However, it is not limited to these amphoteric surfactants.
In the present invention, the surfactant does not include an oily component defined below.
The oily component lowers the melting point of ceramides and inhibits crystallization by interaction with an amphoteric surfactant, thereby obtaining a fine dispersion.

delete

The oily component refers to an oily substance having a polar group such as a hydroxyl group and a carboxyl group, and an oily surfactant that does not dissolve in water. Specifically, it may be an amphiphilic material having a melting point of 40° C. or less and an IOB of 0.4-1.0. Also, preferably, it may be a liquid fatty acid having 6 or more carbon atoms.

The IOB value can be calculated from the molecular structure of the organic concept diagram. The organic value can be calculated from the number of carbon atoms in the molecule, and the inorganic value can be calculated from polar groups such as hydroxyl groups. The IOB value can be calculated in the following way.

IOB = inorganic value/organic value

The oily component includes, but is not limited to, fatty acids, fatty alcohols, polyol esters of sterols, polyol ethers, and acyl monoethanolamides, and fatty acids and polyalkylene glycol ethers of fatty alcohols.

Fatty acids may include 2-ethylhexanoic acid, octanoic acid, decenoic acid, methylhexanoic acid, oleic acid, isostearic acid, and the like. In addition, POP5 sterol ether (POP5 Sterol ether), POE5 phytosterol ether (POE Phytosterol ether), oleth 2, oleth 5, cocoylmethyl monoethanolamide, monocapric acid glycerin (Glyceryl Caprylate), octyl glyceryl ether , decaglycerin pentahydroxystearate, decaglycerin polyricinoleate, hexanol, octanol, methylheptyl alcohol, propylene glycol monolaurate, sorbitan monooleate, sorbitan monoisostearate, etc., but these include It is not limited.

The main oily component IOB is indicated in the table below, and the abbreviation is given below.

MGL: Monoglyceride Laurate

SC-50: Octyl Glyceryl Ether

PL-100: Propylene Glycol Monolaurate

BPS-5: polyoxyethylene 5-phytosteryl ether (PEG-5 Phytosterol)

BT-3: Polyoxyethylene Alkylether (3EO/ C12-C14)

BT-5: Polyoxyethylene Alkylether (5EO/C12-C14)

BO-5: Polyoxyethylene Oleyl Ether (3EO)

DECAGLYN 5HS: Deca Glycerin Pentahydrosystearate

MGU: Monoglyceride Undecylenate

DGMO-90: Diglycerin Monooleate

C-11S: Lauroyle Methy Monoethanolamide

Hydrophilic surfactants refer to anionic surfactants, cationic surfactants, and nonionic surfactants that can be used in cosmetics, pharmaceuticals, and food.

Cationic surfactants that can be used in the present invention include lautrimonium chloride, distearyldimonium chloride, steatrimonium chloride, stearamidopropyl dimethyamine Lactate, behentrimonium chloride, benzalkony um chloride, and the like.

Examples of anionic surfactants usable in the present invention include sodium lauryl sulfate, sodium polyoxyethylene laurylether sulfate, polyoxyethylene alkyl ether carboxylate, and alkyl ether phosphate. Alkyl Ether Phosphate salt, Polyoxyethylenalkyl (C12-C14) Ether Phosphate, Sodium Lauroyl Methylaminopropionate, Polyoxyethylene Lauryl Ethyl acetate (Laureth-6 Carboxylate), potassium myristate (Potassium Myristate), polyoxyethylene (EO2) dialkyl (C12-C15) ether phosphoric acid (Polyoxyethylene Dialkyl Ether Phosphate), sodium lauryl phosphate (Sodium Lauryl Phosphate), etc. There is this.

Nonionic surfactants usable in the present invention include hydrophobic substances such as polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene alkyl phenol ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and sucrose fatty acid ester.性) There is a polymer activator synthesized by block polymerization or graft polymerization of a unit and a hydrophilic unit.

Another aspect of the present invention is to provide cosmetics and pharmaceuticals comprising the above-described novel ceramide transparent aqueous dispersion composition.

The ingredients included in the cosmetic of the present invention include ingredients commonly used in cosmetics in addition to the ceramide transparent aqueous dispersion composition, such as stabilizers, solubilizers, conventional adjuvants such as vitamins, pigments and fragrances, and carriers. .

The cosmetic of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, It may be formulated as an oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, a nourishing lotion, a nourishing cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, or a powder.

When the cosmetic formulation is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. .

When the cosmetic formulation is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane/butane or a propellant such as dimethyl ether.

When the cosmetic formulation is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3 -Butylglycol oil, glycerol fatty ester, polyethylene glycol or fatty acid ester of sorbitan.

When the cosmetic formulation is a suspension, as a carrier component, water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose , aluminum metahydroxide, bentonite, agar or tracanth may be used.

When the cosmetic formulation is surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether sulfate as carrier ingredients , alkylamidobetaine, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamide, vegetable oil, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

Pharmaceuticals containing the transparent ceramide aqueous dispersion composition of the present invention may further include a pharmaceutically acceptable carrier, for example, lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia gum, calcium phosphate, alginate. , gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and/or mineral oil. can do. The pharmaceutical of the present invention may further include a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, and the like, in addition to the above components. Suitable pharmaceutically acceptable carriers and agents are described in detail in Remington's Pharmaceutical Sciences (19th ed., 1995).

The transparent ceramide aqueous dispersion composition of the present invention is excellent in stability over time and is a cosmetic and pharmaceutical raw material excellent in function, texture, and appearance.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those of ordinary skill in the art to which the present invention pertains that the scope of the present invention is not limited by these examples.

Example

I. Review of emulsifying and solubilizing agents

<Production method>

It was heated to 90° C. or higher to dissolve the oily component and ceramide, and after adding surfactant and purified water at 80° C., finely dispersed at 1000 rpm for 5 minutes with a homomixer, cooled and left at 40° C.

Thereafter, in order to confirm the stability after a long period of time, the appearance was evaluated visually after leaving it for 6 months (2 months at room temperature, 2 months at 40°C, and 2 months at 5°C).

<Prescription and Results>

The components listed in Table 1 were used, and commercially available products were used as test samples. The pH was adjusted to 6.0 with an aqueous caustic soda solution.

After preparing the ceramide aqueous dispersion composition as prescribed in Table 1, the appearance was visually evaluated, and the results are shown in Table 1 below (content is % by weight).

Comparative Example 1-1 Example 1-1 Example 1-2 Examples 1-3 Examples 1-4 Ceramide III 0.1 0.1 0.1 0.1 0.1 isostearic acid 0.5 0.5 0.5 0.1 0.1 BO-20 2.0 1.0 amphoteric surfactant CAB30 5.0 ISAB 5.0 AM301 4.0 4.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior sedimentation Transparency Transparency Transparency Transparency

BO-20: OLETH-20 (polyethylene glycol ether of Oleyl Alcohol)

CAB30 (30%): Cocamidopropyl Betaine

ISAB (30%): Isostearamido Propyl Betaine

AM301 (30%): Lauryl Betaine

As a result of the experiment, it was possible to obtain a stable ceramide microdispersion using an amphoteric surfactant.

II. polyoxyethylene alkyl ether and amphoteric surfactant

<Production method>

A ceramide microdispersion was prepared in the same manner as in I above by changing the ratio of polyoxyethylene alkyl ether oleyl alcohol and amphoteric surfactant. Thereafter, in order to confirm the stability after a long period of time, the appearance was evaluated visually after leaving it for 6 months (2 months at room temperature, 2 months at 40°C, and 2 months at 5°C).

<Prescription and Results>

The prescription and results are shown in Table 2 below (content is % by weight).

Comparative Example 2-1 Example 2-1 Ceramide III 0.1 0.1 isostearic acid 0.1 0.1 BO-20 0.1 1.0 AM301 0.1 4.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) Exterior cloudiness, precipitation Transparency

As a result of the experiment, crystals were precipitated in the series with a lot of BO-20, but in the series with a lot of amphoteric surfactants, the transparent state was maintained for a long time of more than 6 months.

III. amphoteric surfactant review of the kind

<Production method>

By changing the ratio of polyoxyethylene oleyl alcohol (BO-20) and amphoteric surfactant, a ceramide microdispersion was prepared in the same manner as in I above. Thereafter, in order to confirm the stability after a long period of time, the appearance was evaluated visually after leaving it for 6 months (2 months at room temperature, 2 months at 40°C, and 2 months at 5°C).

<Prescription and Results>

The prescription and results are shown in Table 3 below (content is % by weight).

Example 3-1 Example 3-2 Example 3-3 Example 3-4 Ceramide III 0.1 0.1 0.1 0.1 isostearic acid 0.5 0.5 0.5 0.5 BO-20 1.0 2.0 1.0 1.0 amphoteric surfactant LSB 3.5 4.0 AM301 3.5 LAB-30 3.5 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior transparent, stable transparent, stable transparent, stable transparent, stable

LSB: Lauramidopropyl Hydroxysultaine

LAB-30: Laurylamido propyl Betaine

As a result of the experiment, it was confirmed that stable microdispersions could be obtained with various amphoteric surfactants. In addition, it was confirmed that when the amount of BO-20 increases compared to the amphoteric surfactant, an unstable fine dispersion is produced, and when BO-20 is mixed, a transparent material can be obtained for a long time of 6 months or more with a small amount of surfactant.

IV. nonionic Use with surfactants

<Production method>

Various nonionic surfactants were used alone or in combination with an amphoteric surfactant to produce a ceramide microdispersion as in I above. Thereafter, in order to confirm the stability after a long period of time, the appearance was evaluated visually after leaving it for 6 months (2 months at room temperature, 2 months at 40°C, and 2 months at 5°C).

<Prescription and Results>

The prescription and results are shown in Table 4 below (content is % by weight).

Comparative Example 4-1 Comparative Example 4-2 Comparative Example 4-3 Comparative Example 4-4 Comparative Example 4-5 Example 4-1 Ceramide II 0.1 0.1 0.1 0.1 0.1 0.1 PSR-5 0.1 0.1 0.1 0.1 0.1 0.1 HCO60 5.0 Sucrose Fatty Acid SL-18 5.0 DECAGLYN 1L 5.0 CDE 5.0 1.0 TL-10 5.0 amphoteric surfactant AM301 5.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior precipitate precipitate precipitate precipitate precipitate Transparency

PSR-5: polyoxypropylene (5) sterol ether

HCO-60: Polyoxyethylene Hydrogenate Castor Oil

Sucrose fatty acid SL-18: 40%

DECAGLYN 1L: Polyglyceryl-10 Laurate

CDE: Coconut diethanolamide

TL-10: Polyoxyethylene (20) Sorbitan Monolaurate

As a result of the experiment, a ceramide fine particle dispersion could not be obtained only with a nonionic surfactant. On the other hand, when a small amount of a nonionic surfactant (coconut diethanolamine) was used together with an amphoteric surfactant, a stable microdispersion could be obtained for a long time of 6 months or more.

V. with cationic surfactants combination

<Production method>

The combined use of various cationic surfactants and amphoteric surfactants produced ceramide microdispersions in the same manner as in I above.

<Prescription and Results>

The prescription and results are shown in Table 5 below (content is % by weight).

Comparative Example 5-1 Comparative Example 5-2 Comparative Example 5-3 Comparative Example 5-4 Comparative Example 5-5 Ceramide III 0.1 0.1 0.1 0.1 0.1 PSR-5 0.1 0.1 0.1 0.1 0.1 cation
Surfactants LTC 5.0 5.0 5.0 STC 5.0 LIPOTHOQUAD O-12 5.0 1.0 MPS 5.0 AM301 5.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior precipitate precipitate precipitate precipitate precipitate

LTC: Lautrimonium Chloride

STC: Steatrimonium Chloride

LIPOTHOQUAD O-12: PEG-2 Oleammonium Chloride

MPS: Stearamidopropyl Alkylamine Lactate

As a result of the experiment, it was not possible to obtain a fine particle dispersion of ceramide with only cationic surfactant. In addition, even if the amphoteric surfactant was included, precipitation occurred when the content did not constitute most of the total surfactant.

IV. Combination of anionic surfactants

<Production method>

Ceramide microdispersion was prepared by carrying out the same conditions as in I above with various anionic surfactants and amphoteric surfactants.

<Prescription and Results>

The prescription and results are shown in Table 6 below (content is % by weight).

Example 6-1 Example 6-2 Comparative Example 6-1 Comparative Example 6-2 Comparative Example 6-3 Ceramide I 0.1 0.1 0.1 0.1 0.1 BPS-5 0.1 0.1 0.1 0.1 0.1 amphoteric surfactant AM301 5.0 CAB30 5.0 anionic surfactant DDP-2 1.0 5.0 ECTD-3 1.0 5.0 DOP-8N 5.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior Transparency Transparency precipitate precipitate precipitate

BPS-5: polyoxyethylene 5-phytosteryl ether (PEG-5 Phytosterol)

DDP-2: Polyoxyethylene dialkyl (C12-C14) Ether Phosphate

ECTD-3N: Sodium Trideceth-4 Carboxylate

DOP-8: Sodium Polyoxyethylene Dioleylether Phospate (8E0)

As a result of the experiment, a ceramide fine particle dispersion could not be obtained with an anionic surfactant alone.

VII. Review of oily ingredients

<Production method>

By changing various oily components and changing the type and amount of surfactant, a ceramide microdispersion was prepared in the same manner as in I above.

<Prescription and Results>

The prescription and results are shown in Table 7 below (content is % by weight).

Example 7-1 Example 7-2 Example 7-3 Example 7-4 Ceramide III 0.1 0.1 0.1 0.1 oily ingredients PL-100 MGK 1.0 BO-5 1.0 BO-2 1.0 1.0 amphoteric
Surfactants LMEB 4.0 AM301 4.0 6.0 5.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior transparent, stable transparent, stable transparent, stable transparent, stable
PL-100: Propylene Glycol Monolaurate

delete

MGK: Glyceryl Caprate

BO-5: Polyoxyethylene Oleyl Ether (3EO)

As a result of the experiment, the optimal amount of surfactant was changed according to the type of oily component and the type of amphoteric surfactant.

VIII. Review of oily ingredients

<Production method>

A ceramide microdispersion was prepared under the same conditions as I above by changing various oily components and changing the type and amount of surfactant.

<Prescription and Results>

The prescription and results are shown in Table 8 below (content is % by weight).

Example 8-1 Example 8-2 Example 8-3 Example 8-4 Ceramide III 0.1 0.1 0.1 0.1

oily ingredients isostearic acid - - - - oleic acid 0.5 lauric acid 1.0 isodecanoate 1.0 octanoic acid 1.0 amphoteric
Surfactants AM3130N 5.0 5.0 4.0 SOFTAZLINE LSB 4.0 Purified water remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior transparent, stable transparent, stable transparent, stable transparent, stable

AM3130N: Cocamidopropyl Betaine

SOFTAZLINE LSB: Lauramidopropyl Hydroxysultaine

As a result of the experiment, the optimal amount of amphoteric surfactant was changed according to the type of fatty acid. In octanoic acid and isodecanate, a transparent product could be obtained with a small amount of an aspect surfactant.

IX. Review of oily ingredients

<Production method>

A ceramide microdispersion was prepared under the same conditions as I above by changing various oily components and changing the type and amount of surfactant. In order to confirm the stability after a long period of time, the appearance was evaluated with the naked eye after being left for 6 months (2 months at room temperature, 2 months at 40°C and 2 months at 5°C).

<Prescription and Results>

The prescription and results are shown in Table 9 below (content is % by weight).

Example 9-1 Example 9-2 Example 9-3 Example 9-4 Example 9-5 Ceramide III 0.1 0.1 0.1 0.1 0.1

oily ingredients BO-5 1.0 0.1 PSR-5 1.0 0.5 DECAGLYN ５HS 1.0 BT-3 1.0 BT-5 1.0 AM3130 3.0 3.0 4.0 3.0 3.0 Purified water Remaining amount (up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior transparent, stable transparent, stable transparent, stable transparent, stable transparent, stable

DECAGLYN 5HS : Deca Glycerin Pentahydrosystearate

BT-3: Polyoxyethylene Alkylether (3EO/ C12-C14)

BT-5: Polyoxyethylene Alkylether (5EO/C12-C14)

As a result of the experiment, when polyoxyethylene alkyl ether was used together, a transparent product could be obtained for a long period of more than 6 months with a small amount of amphoteric surfactant.

X. Review of oily ingredients

<Production method>

By changing various oily components and changing the type and amount of surfactant, a ceramide microdispersion was made in the same manner as in I above.

<Prescription and Results>

The prescription and results are shown in Table 10 below (content is % by weight).

Example 10-1 Example 10-2 Example 10-3 Example 10-4 Example 10-5 Ceramide II 0.1 0.1 0.1 0.1 0.2

oily ingredients
DGMO-90 1.0 Tetraglin-1OV
1.0 PPG5 OLETH 1.0 1.0 C-11S 1.0 2.0 AM3130 4.0 4.0 4.0 4.0 4.0 Purified water Remaining amount (up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) remaining amount
(up to 100) Exterior transparent, stable transparent, stable transparent, stable transparent, stable transparent, stable

DGMO-90: Diglycerin Monooleate

Tetraglyn-1OV: Polyglyceryl-4 Oleate

C-11S: Lauroyle Methyl Monoethanolamide

As a result of the experiment, it was confirmed that even if the type of oily component was changed, a transparent product could be obtained for a long period of 6 months or more when an amphoteric surfactant was used.

XI. cosmetic production

1. Preparation of aqueous dispersion composition

Ａ　Ceramide± (manufactured by Takasago Perfume Co., Ltd.) 　　　　 0.3 wt%

Glycerin Glycerin Glycerin 10.0 wt%

Ａ　Octoxyglycerin (manufactured by Seppic) 　　　 1.0 wt%

B NIKKOL AM3010N (30% cocamidopropyl betaine liquid) 50.0 wt%

Ｂ　Remaining amount of purified water (up to 100% by weight)

<Production method>

Phase A was heated to 90° C. and stirred with a homomixer to melt and disperse, followed by addition of an amphoteric surfactant. If stirring is continued, a solution with uniform transparency will be obtained. After cooling, purified water heated to the same temperature at 70°C was added, cooled and left at 40°C.

2. Shampoo Manufacturing

A shampoo was prepared according to the following prescription by adding the aqueous dispersion composition prepared in 1 above.

(Prescription)

Cocoylmethylaranine Nａ　　　　 10.0 wt%

Cocoylmethyltaurine Nａ　　　　　15.0 wt%

Cocoyldiethanolamide 8.0 wt%

Glycerin 　　　　　　　　　　 5.0 wt%

Aqueous dispersion composition 　　　　　　 10.0 wt%

Purified water 　　　　　　　　　　 remaining amount (up to 100% by weight)

3. Manufacture of face wash

A clear face wash was prepared using the aqueous dispersion composition prepared in 1 above.

(Prescription)

Laurylmethylglucoside 　　10.0 wt%

Lauric acid Nａ　　　　　　　　　　　10.0 wt%

Myristic acid Nａ　　　　　　　　　　15.0 wt%

Glycerin 　　　　　　　　　　　　　30.0 wt%

10.0 wt% of aqueous dispersion composition

Residual amount of purified water (up to 100% by weight)

4. Manufacture of lotion

A lotion was prepared using the aqueous dispersion composition prepared in 1 above.

(Prescription)

Perfume 　　　　　　　　　0.1 wt%

HCOC40　　　　　　0.1 wt%

Ascorbyl phosphate 　0.1 wt%

Citric acid Nａ　　　　　　0.1 wt%

Water dispersion composition 　　10.0 wt%

Residual amount of purified water (up to 100% by weight)

5. Preparation of liquid cosmetics

A cosmetic solution was prepared using the aqueous dispersion composition prepared in 1 above.

(Prescription)

0.1 wt% ascorbyl phosphate

Hyaluronic acid 　　　　　　　　　 0.1 wt%

Adecanol GT-７30 　　　　　　　0.5 wt%

Hydroxyethyl cellulose 　　　 0.1 wt%

Aqueous dispersion composition 　　　　　　　　　　 10.0 wt%

Residual amount of purified water (up to 100% by weight)

Claims (5)

Ceramide 0.01-5.0 wt%,
0.01 to 10 wt% of an oily component,
0.1 to 70% by weight of a surfactant, and
Water-soluble solvent 0.1 to 95.9 wt%
A transparent aqueous dispersion composition comprising: the surfactant essentially includes an amphoteric surfactant, the content of which is greater than 50% by weight of the total surfactant;
Here, the ceramide is ceramide 1 (ceramide EOS), ceramide 2 (ceramide NS), ceramide 3 (ceramide NP), ceramide 4 (ceramide EOH), ceramide 5 (ceramide AS), ceramide 6 (ceramide NH), ceramide 7 (ceramide NH) AP), at least one selected from the group consisting of ceramide 8 (ceramide AH) and ceramide 9 (ceramide EOP),
The oily component is an amphiphilic material having an organic/organic balance (IOB) of 0.4-1.0, and is a fatty acid, fatty alcohol, polyol ester, polyol ether, acyl monoethanolamide, polyalkylene glycol ether of fatty acid, and poly At least one selected from the group consisting of alkylene glycol ether,
The surfactant does not include the oily component. The transparent aqueous dispersion composition according to claim 1, wherein the average particle diameter of the ceramide-containing particles included in the aqueous dispersion composition is 1 to 200 nm. The transparent aqueous dispersion according to claim 1, wherein the surfactant further comprises at least one surfactant selected from the group consisting of an amphoteric surfactant or an ionic surfactant and a nonionic surfactant. composition. A cosmetic comprising the transparent aqueous dispersion composition according to any one of claims 1 to 3. delete