KR101624764B1

KR101624764B1 - Dentifrice composition

Info

Publication number: KR101624764B1
Application number: KR1020117014771A
Authority: KR
Inventors: 츠구노 테라바야시; 타카시 치카자와; 아유미 아마노; 하루오 카도야
Original assignee: 라이온 가부시키가이샤
Priority date: 2008-12-24
Filing date: 2009-12-21
Publication date: 2016-05-26
Also published as: JP5589849B2; CN102264342B; TWI445551B; TW201034697A; JPWO2010074025A1; JP5867546B2; JP2014144989A; MY155634A; KR20110107327A; CN102264342A; WO2010074025A1

Abstract

(A) at least one selected from ascorbic acid ester and its salt, (B) aluminum lactate and / or potassium nitrate, and the content ratio of component (B) / component (A) 50. < / RTI >

Description

[0001] DENTIFRICE COMPOSITION [0002]

The present invention relates to a composition for oral administration, which is excellent in the inhibitory effect on the sensation of hypersensitivity, exhibits an effect of preventing inflammation in the oral cavity and oral cavity derived from a high periodontal disease, The present invention relates to a tooth abrasive composition which is effective for inhibiting or preventing the symptoms of a toothache.

Periodontal disease is a disease of the oral cavity that occurs alongside tooth decay and accounts for about half of the tooth loss. Most of the periodontal diseases are thought to be infections caused by bacteria, mainly composed of anaerobic gram negative bacteria, and as a result, connective tissue and alveolar bone are destroyed. Clinical findings of this procedure include inflammation, swelling, bleeding, drainage, bad breath, and gum recession.

In the living body, neutrophils have the function of sterilizing bacteria and defending the living body. However, in chronic inflammation, the leakage of cellular components and the production of excessive oxygen radicals have an adverse effect on living tissues. Therefore, it is useful to prevent tissue destruction by active oxygen by using an antioxidant such as ascorbic acid and its derivatives. Patent Document 1, for example, proposes that an ascorbic acid ester and a derivative thereof are blended in a tooth abrasive composition and this is effective for suppressing bad breath and inflammation derived from periodontal disease.

In addition, in the case of having periodontal disease, recession of the gum occurs, and the dentin of the root portion is exposed, and the symptoms of the hypersensitivity may be exacerbated.

Dentin hypersensitivity is defined as transient, very uncomfortable pain caused by the exposure of the dentin of the root portion and any external, chemical, or mechanical stimulation of the dentin. It is thought that this pain is caused by the stimulation of the dental nerve through exposed dentinal tubules.

Conventionally, there have been a lot of studies on the prevention and treatment of dentin hypersensitivity. For example, potassium salts, strontium salts, zinc chloride, aluminum salts and the like as effective ingredients for preventing and treating dentin hypersensitivity have been reported in Patent Documents 2 to 5 and the like. Particularly, the potassium salt has been reported in Patent Document 6 and the like to dull the sensory nerve by the sensory nerve activity lowering action by the increase of the extracellular potassium ion concentration, thereby alleviating pain caused by the hypersensitivity. Also, it has been reported in Patent Documents 6 and 7 that the aluminum salt prevents the irritation from being transmitted to the nerve of the dimension by stenosis or occlusion of the dermal tubule.

In the state of having the hypersensitivity symptoms, since the pain is felt at the time of polishing the teeth, normal brushing is difficult, which makes it difficult to remove the calculus and remove the causative bacteria of periodontal disease sufficiently. In addition, And bad odor originating from periodontal disease is apt to occur. If the pain caused by the hypersensitivity is more effectively alleviated, it is possible to perform the brushing more carefully. However, the antinociception inhibitory component such as aluminum lactate has a bitter taste and has a problem in feeling. Up to now, although Patent Literatures 8 and 9 have been described for improving the feeling of use of a tooth-polishing agent containing a hypersensitive-inhibiting component, these effects are not sufficient. A tooth abrasive compounded with a hypersensitive inhibiting component has a problem that it is difficult to carefully wipe it for a long time due to the use feeling.

Therefore, it is possible to perform more qualitative brushing, to sufficiently remove plaque, to exhibit the effect of preventing periodontal disease, and to exhibit sufficient usability Development of a good tooth abrasive composition is desired.

It is proposed in Patent Document 10 that a component for reducing the sensitivity of teeth such as potassium nitrate as an auxiliary active ingredient may optionally be compounded in an oral care composition containing ascorbic acid ester. However, this technique does not show the use of ascorbic acid ester or its salt in combination with aluminum lactate and / or potassium nitrate nor the content of the positive components, and the above problem is not suggested. From such a technique, it is difficult to expect that a combination of ascorbic acid ester or a salt thereof and aluminum lactate and / or potassium nitrate together with a high sensitivity to hypersensitivity, a bad breath improving effect, an inflammation inhibiting effect and a dental calculus removing effect .

[Prior Art Literature]

[Patent Literature]

Patent Document 1: Japanese Patent Application Laid-Open No. 62-96408

Patent Document 2: Japanese Patent Application Laid-Open No. 61-36212

Patent Document 3: U.S. Patent No. 3863006

Patent Document 4: Japanese Patent Application Laid-Open No. 2006-096696

Patent Document 5: Japanese Patent Application Laid-Open No. 2001-172146

Patent Document 6: JP-A-8-175943

Patent Document 7: JP-A-2003-26556

Patent Document 8: JP-A-2003-73282

Patent Document 9: Japanese Patent Application Laid-Open No. 2001-172146

Patent Document 10: Japanese Patent Laid-Open No. 2005-503322

[Non-Patent Document]

Non-Patent Document 1: Okuda et al., New Oral Microbiology (2002) p. 380

Disclosure of the Invention The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a toothbrush which is excellent in an effect of inhibiting the sensation of hypersensitivity, It is another object of the present invention to provide a tooth abrasive composition which is capable of effectively suppressing symptoms such as bad breath and inflammation originating from periodontal disease with little use of a bitter taste derived from a hypersensitivity- .

(B) at least one selected from ascorbic acid ester and its salt, (B) aluminum lactate and / or potassium nitrate, (B) at least one selected from ascorbic acid ester and its salt, ) Component / (A) is contained in a ratio of 2 to 50 in a mass ratio, the positive components act synergistically, so that they are excellent in the effect of suppressing the hypersensitivity symptoms, and even in the case of users with perceptual sensitization symptoms, As a result, the dental plaque removing effect is enhanced. As a result of infiltration of the active ingredient, a high inflammation-inhibiting effect is exhibited, and symptoms such as bad breath and inflammation derived from periodontal disease can be effectively suppressed, It was found that this good tooth abrasive composition was obtained.

The tooth abrasive composition of the present invention is a tooth abrasive composition comprising (A) at least one member selected from ascorbic acid ester and its salt, and (B) aluminum lactate and / or potassium nitrate at a specific ratio, The bitterness is improved, and the feeling of use is good. At the same time, since the feeling of use is good, the user can brush the teeth more carefully and with more time, even in use in a state of having a sensation of hypersensitivity, and the dental plaque removal effect is more enhanced and expressed, and ascorbic acid ester or It is possible to satisfactorily exhibit the inflammatory and bad breath suppressing effect due to ascorbic acid ester or its salt against inflammation and bad breath caused by periodontal disease and the like due to periodontal disease, Prevention or suppression.

In the present invention, by the synergistic action of the positive components by combining the component (A) and the component (B) in an appropriate ratio, the case where the component (A) or the component (B) alone is mixed, A special effect that can not be achieved is obtained. Particularly, when the content of the component (A) is 0.1 to 1 mass%, the content of the component (B) is 2 to 8 mass%, and the content of the component (B) / the component (A) is 4 to 30 in mass ratio, , A superior tooth sensitivity suppressing effect, an inflammation suppressing effect in oral cavity caused by periodontal disease, a bad breath suppressing effect, and a dental calculus removing effect, and a good feeling of use can be obtained.

Accordingly, the present invention provides the following tooth abrasive composition.

Claim 1:

Claim 2:

Wherein the ascorbic acid ester is selected from the group consisting of ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-2-polyphosphoric acid ester, ascorbic acid- Wherein the dentifrice composition is at least one member selected from the group consisting of citric acid ester, citric acid ester, citric acid ester, citric acid ester,

Claim 3:

The tooth abrasive composition according to claim 1, wherein the ascorbic acid ester is ascorbic acid phosphate ester.

[Claim 4]

The tooth abrasive composition according to claim 1, wherein the component (A) is a sodium salt or a magnesium salt of ascorbic acid phosphate ester.

Claim 5:

The tooth-polishing composition according to any one of claims 1 to 4, which contains 0.05 to 2% by mass of the component (A) and 1 to 9% by mass of the component (B).

[Claim 6]

(A) is contained in an amount of 0.1 to 1 mass%, the component (B) is contained in an amount of 2 to 8 mass%, and the content of the component (B) / the component (A) The tooth-polishing composition according to any one of claims 1 to 4,

Claim 7:

The tooth-polishing composition according to any one of claims 1 to 6, further comprising an abrasive, a viscosifier, a binder and a surfactant, and is formulated as a softener.

Claim 8

7. The tooth abrasive composition according to any one of claims 1 to 7, which is for inhibiting or preventing hypersensitivity and periodontal disease.

INDUSTRIAL APPLICABILITY The tooth abrasive composition of the present invention is excellent in an effect of inhibiting the hypersensitivity symptoms and exhibits a high dental calculus removing effect, a bad breath improving effect and an inflammation suppressing effect in the oral cavity, a little bitter taste derived from a hypersensitive component, The user can brush the teeth delicately over a long period of time even with the symptoms of hypersensitivity, and can be effectively used for preventing and treating periodontal hypersensitivity and periodontal disease.

BEST MODE FOR CARRYING OUT THE INVENTION The tooth abrasive composition of the present invention comprises at least one selected from (A) ascorbic acid ester and its salt, (B) aluminum lactate and / or potassium nitrate .

As the ascorbic acid ester, one or two or more of the hydroxyl groups of 2, 3, 5 and 6 of ascorbic acid are composed of esters of phosphoric acid, polyphosphoric acid, sulfuric acid, fatty acid and other pharmaceutically acceptable compounds Can be used. For example, ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-6-phosphate ester, ascorbic acid-2-polyphosphoric acid ester, ascorbic acid- 2-palmitic acid ester, ascorbic acid-6-palmitic acid ester, ascorbic acid-2-stearic acid ester, ascorbic acid-6-stearic acid ester, ascorbic acid- Ester, ascorbic acid-2,6-palmitic acid ester, and the like. Examples of such salts include alkali metal salts such as sodium salt, potassium salt, calcium salt and magnesium salt, and alkaline earth metal salts.

These ascorbic acid esters and salts thereof may be contained singly or in combination of two or more kinds. Among the ascorbic acid esters, in particular, from the standpoint of stability of the composition, the hydroxyl group at the second or third position of ascorbic acid Esterified ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-2-polyphosphoric acid ester, ascorbic acid-2-sulfuric acid ester, ascorbic acid-2-palmitic acid ester , Ascorbic acid-2-stearic acid ester, and the like are preferably used.

Among the ascorbic acid esters, phosphoric acid esters are absorbed in vivo and then taken as dephosphoric acid and act as ascorbic acid by an enzyme phosphatase widely present in the living body. Therefore, And particularly preferable. Of the ascorbic acid phosphoric acid ester salts, magnesium salt and sodium salt are particularly preferable from the viewpoint of the halitosis and inflammation-inhibiting effect derived from periodontal disease.

These ascorbic acid esters are commercially available, for example, from Digestion Electric Co., Ltd. or DSM Nutrition Japan Co., Ltd., and are available.

The content of the ascorbic acid ester and the salt thereof is preferably 0.05 to 2% (mass%, the same applies hereinafter), particularly 0.1 to 1%, of the whole composition from the viewpoint of the bad breath and inflammation-inhibiting effect derived from periodontal disease. When it is less than 0.05%, the effect of inhibiting the bad breath or inflammation due to periodontal disease may not be sufficient, and when it exceeds 2%, the bitterness may be felt at the time of use and may be inferior to the feeling of use.

Aluminum lactate and potassium nitrate are used as perinatal hypersensitizers. Aluminum lactate or potassium nitrate alone may be blended, or aluminum lactate and potassium nitrate may be used in combination.

As the aluminum lactate, for example, those sold by the Musashino Chemical Research Institute may be used.

Potassium nitrate, for example, which is commercially available from Otsuka Chemical Co., Ltd. can be used.

The blending amount of aluminum lactate and / or potassium nitrate is preferably 1 to 9%, more preferably 2 to 8%, of the total composition. If the blending amount is less than 1%, the effect of inhibiting the hypersensitivity may not be satisfactorily exhibited, and the brushing may not be satisfactory, so that the removal of tartar is sometimes insufficient. When the blending amount is more than 9% Not only can not be expected to increase, but bitter tastes are produced, and sometimes it is out of use.

The content of aluminum lactate is preferably 1 to 5%, particularly preferably 1 to 3%, of the entire composition from the viewpoint of perceptual hypersensitivity. If less than 1%, the effect of inhibiting the hypersensitivity is not satisfactorily exhibited, so that the brushing can not be satisfied and the removal of the calculus is sometimes insufficient, and if it exceeds 5%, the effect of increasing the content is expected to increase Not only is there a bitter taste, but it can be inferior to feeling.

The content of potassium nitrate is preferably from 1 to 8%, particularly preferably from 2 to 7%, of the total composition from the viewpoint of the perceptual hypersensitivity effect. Less than 1% may not satisfactorily inhibit the sensation of hypersensitivity, making the brushing unsatisfactory and insufficient removal of tartar. In excess of 8%, the bitter taste may be too strong and the feeling of use may be poor.

In the present invention, the content ratio ((B) / (A)) of the component (A) and the component (B) is 2 to 50, preferably 4 to 30 in terms of a mass ratio. It is excellent in use feeling, and also has a high bad breath suppressing effect in the oral cavity, an inhibitory effect on the sensation of hypersensitivity, and a dental plaque removing effect. In addition, with the above mixing ratio, the taste is good, the feeling is excellent, and the pain at the time of wiping can be suppressed. As a result, the prevention effect of bad breath and inflammation originating from periodontal disease and the dentin hypersensitivity inhibiting effect are enhanced, More qualitative and sufficient brushing is possible, and more advanced plaque removal is possible. If the mass ratio is less than 2, the effect of mitigating the hypersensitivity can not be obtained sufficiently, and the brushing can not be satisfied, so that the dental calculus removal effect can not be obtained. When the mass ratio is more than 50, the sufficient effect of suppressing bad breath and inflammation can not be obtained. It is impossible to achieve the action and effect of the present invention.

The tooth abrasive composition of the present invention is prepared in the form of a paste, a gel, a liquid, a liquid, a solid, a gum and the like, and is used as a toothbrush, a liquid toothbrush, a toothbrush, A powder tooth dentifrice, a liquid tooth dentifrice, and the like. The tooth dentifrice is prepared especially as a dentifrice, and other additives may be added as optional components in addition to the essential components according to the form of the dentifrice.

In the case of a fibrillated powder, it is prepared by mixing components such as abrasives, viscosifiers, binders, surfactants, sweeteners, preservatives, coloring agents (pigments), preservative stabilizers, various active ingredients, can do.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, aluminum hydroxide, calcium hydrogen phosphate dihydrate and anhydrous calcium salt, calcium pyrophosphate, hydroxyapatite, Zirconium silicate, alumina, magnesium carbonate, magnesium triphosphate, and synthetic resin based abrasive. Of these, silica-based abrasives are suitably used. The content of the abrasive is usually 0 to 40%, particularly 2 to 30%.

As the viscosifying agent, polyhydric alcohols, sugar alcohols and the like can be used, and for example, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol , Xylite, maltitol, lactite, and the like. The content of the roughening agent is usually 1 to 60%.

Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose, rubbers such as xanthan gum, trachant rubber, karaya rubber and gum arabic, polyvinyl alcohol, crosslinked sodium polyacrylate, non-crosslinked polyacrylic acid Carboxyvinyl polymer such as sodium carboxymethylcellulose, carboxymethylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, sodium carboxymethylcellulose, sodium carboxymethylcellulose, sodium carboxymethylcellulose, The content of the binder is usually 2 to 10% of the composition.

As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants may be contained. Examples of the anionic surfactant include sodium alkylsulfuric acid such as sodium laurylsulfate and sodium myristylsulfate, sodium N-acylsarcosinate such as sodium N-lauroyl sarcosinate, sodium N-acylsarcosinate such as N-myristoyl sarcosinate, N-acyl glutamate such as sodium sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, sodium laurylsulfoacetate and sodium N-palmitoyl glutamate, sodium N-methyl-N-acyltaurine, -Acylalanine sodium, sodium? -Olefin sulfonate, and the like. Examples of the nonionic surfactant include sugar alcohol fatty acid esters such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters and sucrose fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyethylene glycol fatty acid esters and the like Polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil and the like, ether type active agents such as polyoxyethylene hydrogenated castor oil, and lauric acid diethanolamide Fatty acid alkanolamides. Examples of cationic surfactants include alkylammonium, alkylbenzylammonium salts and the like. Examples of the positive surfactant include betaine acetate, imidazolinium betaine, and lecithin.

The blending amount of the surfactant is usually 0 to 15%, particularly 0.5 to 10% of the composition.

The perfume can be at least one selected from the group consisting of peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, time oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, , Lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, bayu, lemongrass oil, olganan oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, Natural fragrance such as aboriginal rose, orange flower and the like, and processing of these natural fragrances (such as cutting of a current portion, cutting of a wake portion, classification, liquid-liquid extraction, essence, ) Perfume and at least one perfume selected from the group consisting of menthol, carboen, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-l, 2-diol, thymol, linalool, linallacetate, limonene , Menthone, menthyl acetate, N-substituted-parramentane-3-carboxamide, pinene, octyl But are not limited to, aldehyde, citral, fullergan, carbitol acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycityate, vanillin, undecalactone, A single-component flavor such as alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioacetate, It is possible to use a known perfume material used in a tooth polishing composition such as a combination perfume such as Apple flavor, Banana flavor, Pineapple flavor, Grapeflavor, Mango flavor, Butter flavor, Milk flavor, Fruit mix flavor and Tropical fruit flavor.

The content is not particularly limited, but it is preferable that the above-mentioned perfume material is used in an amount of 0.000001 to 1% in the formulation. It is preferable that 0.1 to 2.0% of the fragrance material is used in the preparation composition.

Examples of the sweetener include saccharin sodium, stevioside, stevia extract, neohespyridine dihydrochalcone, glycyrrhizin, perylaltein, p-methoxycinnamaldehyde, aspartame, xylitol and the like.

Examples of the preservative include palooxybenzoic acid esters such as butylparaben, propylparaben and ethylparaben, sodium benzoate, cetylpyridinium chloride, isopropylmethylphenol, potassium sorbate and the like.

Examples of the colorant include blue No. 1, blue No. 4, and green No. 3.

Examples of the preservative stabilizer include vitamins such as vitamin E, sulfites such as sodium sulfite, sodium pyrosulfite and sodium hydrogen sulfite, butylhydroxytoluene, and propyl gallate.

Examples of the various effective components include compounds other than the components (A) and (B), for example, monofluorophosphates such as sodium monofluorophosphate, fluorine-containing compounds such as sodium fluoride, potassium salts of positive Salts, and the like, water-soluble phosphoric acid compounds such as allantoin, allantoin chlorohydroxyammini, hinokitiol, sodium chloride, dl-tocopherol acetate, coenzyme Q10, dihydrocholesterol,? -Bisabolol, crohexidine salts, Chelate phosphate compounds such as isopropylmethylphenol, gumirinol extract, azulene, glycyrrhizin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll and glycerophosphate, copper compounds such as copper gluconate, strontium chloride, berberine, Xanthan gum, lactic acid and its derivatives, pyrophosphate, tripolyphosphate, zeolite, methoxyethylene maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocole Terbinafine hydrochloride, terrine, chloramphenicol, benzethonium chloride, benzalkonium chloride, trichlorocarbonylide, zinc citrate, dextrasia, mutanase, protease, Japanese Angelica root extract, yellow white extract, Extracts such as sperm, sperm, rosemary, golden, and vanilla can be blended in an effective amount to the extent that the effect of the present invention is not hindered.

The content of these optional components may be a conventional amount within a range not hindering the effect of the present invention.

The tooth abrasive composition of the present invention can be used as a receptacle container in addition to a tube such as an aluminum laminate tube or a glass evaporated plastic tube as well as a film packaging container such as a dispenser container or a pillow package by mechanical or differential pressure, Hollow), a bottle formed by molding such as a press or a vacuum, or the like.

Example

Hereinafter, the present invention will be described in detail by way of Experimental Examples, Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples, the amounts are all% by mass.

[Examples, Comparative Examples]

The teeth abrasive composition having a composition shown in Tables 1 to 4 (soft skins) was prepared by a routine method and evaluated by the following experiment. The results are shown in Tables 1-4.

As the respective components used for preparing these tooth abrasive composition, there were used ascorbic acid-2-phosphate ester magnesium (ascorbic acid PM, manufactured by Digestion Co., Ltd.), ascorbic acid-2-phosphate ester sodium (Stay C- (Produced by Torishon Japan), ascorbic acid-2-sulfuric acid ester (manufactured by ITO), aluminum lactate (manufactured by Musashino Chemical Research Institute, Ltd.) and potassium nitrate (manufactured by Otsuka Chemical Co., In addition to the above, it is also possible to use a conventional cosmetic raw material (such as precipitated silica, sodium hydroxide, viscous silica, carboxymethylcellulose, sodium lauryl sulfate, sodium monofluorophosphate, sorbitol, anhydrous silicic acid, propylene glycol, (粧基)) or Quasi-drug raw material specification 2006 was used. Regarding the sorbit, a 70% aqueous solution was used to prepare a tooth abrasive composition.

[Experimental Example 1] Evaluation of odor improvement rate from periodontal disease

The evaluation was made using 10 volunteer subjects having symptoms of perception sensitivity, subjective symptoms of periodontal disease (swelling and bleeding of gums) and bad breath. First, oral cleaning was stopped for one day to the subject. One liter of breathing was taken from a fluorine resin sampling container (Tedorabagu N type 1L size, manufactured by Sampler Tech Co., Ltd.), and 10 steerers were subjected to periodontal disease- The level of the bad breath was evaluated, and the rating was S1.

Then, 1 g of the tooth polishing agent was used once, and the teeth were used twice a day for one month by a conventional method (toothbrushing using a toothbrush for 3 minutes), and then oral cleaning was stopped for one day, 1 L of breathing was taken in a sampling container (Tedorabagu N type 1L size, manufactured by Sampler Tech), and the level of halitosis originating from the periodontal disease was evaluated according to the evaluation criteria described below by 10 steerers.

The improvement degree of bad breath derived from periodontal disease of each subject was calculated according to the following equation, and the average value of 10 subjects was calculated. This average value was judged according to a criterion to be described later.

Improvement of bad breath from periodontal disease = S1-S2

5: There is bad breath from extremely periodontal disease.

4: There is bad breath from strong periodontal disease.

3: There is some bad breath from periodontal disease.

2: There is a bad breath from a slight periodontal disease.

1: There is almost no periodontal disease from the periodontal disease.

0: There is no bad breath from periodontal disease.

◎: 3.5 points or more and 5 points or less

○: 2.5 points or more and less than 3.5 points

△: 1 point or more and less than 2.5 points

×: less than 1 point

[Experimental Example 2] Evaluation of feeling

Each tooth was used to apply 10 g of the tooth dentifrice to 10 persons who had symptoms of dentin hypersensitivity, and the tooth was used for 3 minutes (brushing for 3 minutes using a toothbrush) by a conventional method, Sensory feeling such as bitter taste was evaluated according to the following criteria, and an average of 10 persons was obtained. This average value was judged according to the criteria described later.

4: Do not feel bitter taste at all, feeling very good.

3: Almost no sense of bitterness, no problem in feeling.

2: Feeling a bitter bitter taste, feeling a little problem.

1: I feel strong bitter taste, can not bear to use.

◎: 3.5 points or more and 4 points or less

○: 3 points or more and less than 3.5 points

△: 2 points or more and less than 3 points

X: Less than 2 points

[Experimental Example 3] Evaluation of inhibitory effect on hypothalamus

Each tooth skirt was applied to 10 persons who had symptoms of dentin hypersensitivity. 1 g of tooth dentifrice was used once and used for 5 minutes by a normal method (toothbrush was used for brushing for 5 minutes) And the average of 10 persons was obtained. This average value was judged according to the criteria described later.

4: You can brush your teeth for 5 minutes without feeling any pain.

3: I feel a slight pain, but I can brush the teeth for 3 minutes, no problem level.

2: I feel a bit of pain, but I can brush my teeth for 1 minute.

1: I feel pain, can not brush teeth for 1 minute.

◎: 3.5 points or more and 4 points or less

○: 3 points or more and less than 3.5 points

△: 2 points or more and less than 3 points

X: Less than 2 points

[Experimental Example 4] Evaluation of dental plaque removal effect

Each tooth was applied to 10 persons who had symptoms of dentin hypersensitivity. After 1 g of tooth abrasive was used for 3 minutes (brushing for 3 minutes using a toothbrush) by a conventional method, Dental plaque was dyed according to the method of the present invention and the dental plaque stained by dyes on each of the four dental surfaces (mesial, distal, lips, and tongue sides) , And PI (plaque index) was calculated by the following formula. The average PI of 10 subjects was determined according to the criteria described below.

PI (%) = ((sum of tooth surfaces attached to calculus) / (number of teeth to be tested)) × 100

4: Less than 25%

3: 25% or more and less than 45%

2: 45% or more and less than 75%

1: 75% or more

◎: 3.5 points or more and 4 points or less

○: 3 points or more and less than 3.5 points

△: 2 points or more and less than 3 points

X: Less than 2 points

[Experimental Example 5] Evaluation of inflammation-inhibiting effect

On the hamster chic pouch, inflammation was caused by burning, and about 0.1 g of the sample (soft skim composition) was applied on the porch. After 5 hours, the porch was removed. The mass of the porcine was measured and the edema inhibition rate was calculated from the mass difference with the untreated site (opposite side porch). 8 specimens were subjected to this, and the average edema inhibition rate (%) for the untreated region was calculated, and the following criteria were determined.

Average edema inhibition (%)

= 100 - ((mass of untreated site - mass of sample application site) / (mass of untreated site)) x 100

&Amp; cir &: The average edema inhibition rate is 20% or more

○: Average edema inhibition rate is 10% or more and less than 20%

△: Average edema inhibition rate is 5% or more and less than 10%

X: Average edema inhibition rate is less than 5%

*: Sodium L-ascorbate: manufactured by Fuso Chemical Industry Co., Ltd.

From the results shown in Tables 1 to 4, it can be understood from the results of Tables 1 to 4 that, in the composition in which any one of the components (A) and (B) according to the present invention has an undivided total composition or an inadequate mass ratio of (B) / (A) , A hypersensitivity inhibitory effect, a dental plaque removal effect, and an inflammation inhibitory effect, and satisfactory effects were not exhibited. On the other hand, it has been confirmed that the tooth abrasive composition of the present invention is excellent in bad breath improving effect, retarding effect on perception of hypersensitivity, dental plaque removing effect, inflammation inhibiting effect, and good taste without bitter taste.

Next, the tooth-polishing composition of the following composition was prepared in the same manner as described above and evaluated in the same manner.

[Example 19] A liquid tooth abrasive

Anhydrous silicic acid 10.0%

Xanthan Rubber 1.0

Sodium saccharin 0.1

70% sorbitol solution 35.0

Glycerin 20.0

Propylene glycol 3.0

Sodium lauryl sulfate 1.2

Sodium bicarbonate 2.0

Decaglyceryl laurate 0.5

Sodium monofluorophosphate 0.73

Potassium nitrate 5.0

Magnesium ascorbic acid-2-phosphate 0.5

Sodium hydroxide 0.4

Fragrance 0.8

Blue No. 1 0.001

Purified water Remainder

Total 100.0%

(B) / (A) = 10.0

The evaluation results are as follows.

Improvement rate of bad breath from periodontal disease ◎

Feeling ◎

Suppression of hypersensitivity ◎

Removal of plaque ◎

Anti inflammatory effect ◎

The same results were obtained when aluminum lactate was used instead of potassium nitrate. The same results were obtained when sodium ascorbic acid-2-phosphate was used instead of magnesium ascorbin-2-phosphate.

[Example 20] A liquid tooth abrasive

Anhydrous silicic acid 10.0%

Xanthan Rubber 1.0

Sodium saccharin 0.1

70% sorbitol solution 35.0

Glycerin 20.0

Propylene glycol 3.0

Sodium lauryl sulfate 1.2

Sodium bicarbonate 2.0

Decaglyceryl laurate 0.5

Sodium monofluorophosphate 0.73

Potassium nitrate 4.0

Magnesium ascorbic acid-2-phosphate 0.2

Sodium hydroxide 0.4

Fragrance 0.8

Blue No. 1 0.001

Purified water Remainder

Total 100.0%

(B) / (A) = 20.0

The evaluation results are as follows.

Improvement rate of bad breath from periodontal disease ◎

Feeling ◎

Suppression of hypersensitivity ◎

Removal of plaque ◎

Anti inflammatory effect ◎

Claims

(B) 1 to 9 mass% of at least one of (B) at least one selected from the group consisting of (A) ascorbic acid ester and its salt and (B) aluminum lactate and potassium nitrate, Wherein the content ratio of the component (A) is 2 to 50 in mass ratio.

The method according to claim 1,
Wherein the ascorbic acid ester is selected from the group consisting of ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-2-polyphosphoric acid ester, ascorbic acid- Stearic acid ester, stearic acid ester, myristic acid ester, and ascorbic acid-2-stearic acid ester.

The method according to claim 1,
Wherein the ascorbic acid ester is ascorbic acid phosphate ester.

The method according to claim 1,
Wherein the component (A) is a sodium salt or a magnesium salt of ascorbic acid phosphate ester.

5. The method according to any one of claims 1 to 4,
Wherein the composition contains 0.1 to 1 mass% of component (A) and 2 to 8 mass% of component (B), and a content ratio of component (B) / component (A) .

5. The method according to any one of claims 1 to 4,
The tooth abrasive composition according to any one of claims 1 to 3, further comprising an abrasive, a tackifier, a binder and a surfactant.

5. The method according to any one of claims 1 to 4,
Wherein the tooth abrasive composition is used for inhibiting or preventing hypersensitivity and periodontal disease.

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