JP2003026556A - Tooth paste composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tooth paste composition having effects of preventing and treating hyperesthesia. SOLUTION: This tooth paste composition is characterized by containing a synthetic amorphous silicate containing Zirconium bonded as ZrO2 by 1.5-3.5 mass % range with SiO2 , having diffraction peaks at X-ray diffraction angles of 2θ=21-23 deg. (d=4.07-4.09) and 2θ=35-37 deg. (d=2.48-2.50) in the case of calcinating it at 900 deg.C for 1 hr, and also exhibiting pH 8.8-10.5 as a 5 mass % slurry as a grinding agent, and also aluminum lactate.

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition which can effectively prevent and treat dental dentin hypersensitivity. 2. Description of the Related Art Dentin hypersensitivity is a phenomenon in which the enamel or cementum of a tooth is lost and dentin is exposed, and the dentin is exposed to heat and chemicals. When a mechanical exogenous stimulus is given, it causes temporary very unpleasant pain. This is because
It is thought that nerves are stimulated through dentinal tubules, and as a preventive measure with oral hygiene products such as dentifrice,
Methods have been used to block ivory tubules and blunt the nerves. Japanese Patent Application Laid-Open No. 61-36212 discloses a method for blocking dentinal tubules, and a method described in U.S. Pat. No. 3,863,006 for dulling nerves. As dentifrices for preventing dentin hypersensitivity, delicate (Sunstar Co., Ltd.) and Schmitect (Earth Pharmaceutical Co., Ltd.) containing aluminum lactate are commercially available. [0003] When dentin hypersensitivity develops, for example, when eating a sweet or sour fruit, drinking cold water, or brushing teeth, the patient feels pain. Has many adverse effects on [0004] However, the above-mentioned methods have been proposed for the purpose of reducing and eliminating these pains.
Even with these methods, pain reduction and elimination usually require 1
At present, it requires a period of more than a month and is accompanied by pain of the affected person. [0005] Accordingly, there is a strong demand for a composition for the oral cavity which can reduce and eliminate pain in a short period of time and has a more excellent effect of preventing and treating hyperesthesia. On the other hand, abrasives used for toothpaste include finely divided silica, calcium carbonate, dibasic calcium phosphate,
Although there is aluminum hydroxide and the like, in recent years, fluorine-containing toothpaste is becoming mainstream, and among the above-mentioned abrasives, fine powdered silica having the best compatibility with fluorine has become the mainstream of abrasives. It has become important to develop various dentifrices containing. However, the fine silica powder is 4.5 to 4.5.
Since it has a Mohs hardness of 5.0, it has the disadvantage that the polishing power is too high. Also, in the case of hypersensitive dentin, this high abrasive power is a more serious drawback because the dentin is exposed. In order to cover this drawback, zirconium-bonded silicate has been proposed as an abrasive having an appropriate abrasiveness without damaging the teeth (Japanese Patent Publication No. 62-3472).
No. 1, Japanese Patent Publication No. 4-35402). However, when using this abrasive to prepare a dentifrice containing aluminum lactate having an effect of blocking dentinal tubules, there is a disadvantage that the effect of preventing hypersensitivity is lost. The present invention has been made in view of the above circumstances,
An object of the present invention is to provide a dentifrice composition in which fine silicic acid is blended as an abrasive, and the effect of preventing hyperesthesia is remarkably excellent. [0010] [Means for Solving the Problems and DESCRIPTION OF THE INVENTION The present inventors have, as a result of intensive investigations to achieve the above object, zirconium respect SiO ₂ as ZrO ₂ 1.
X-ray diffraction angle 2θ = 21 to 23 ° (d = 4. 3%) when bound in the range of 5 to 3.5% by mass and fired at 900 ° C for 1 hour.
07-4.09) and 2θ = 35-37 ° (d = 2.48)
-2.50), a synthetic amorphous silicate having a pH of 8.8 to 10.5 having a diffraction peak of 5% by mass as a slurry, and aluminum lactate as an active ingredient for preventing hyperesthesia. The present inventors have found that a dentifrice composition formulated as the above can achieve the above-mentioned object and provide excellent preventive and therapeutic effects for hyperesthesia, and have accomplished the present invention. Hereinafter, the present invention will be described in more detail.
Dentifrice composition of the present invention, zirconium bound in the range of 1.5 to 3.5% with respect to SiO ₂ as ZrO ₂ (mass percentage, hereinafter the same), in the case of baked 1 hour at 900 ° C. X Senkai Angle 2θ = 21-23 ° (d = 4.07-4.0)
9) and 2θ = 35-37 ° (d = 2.48-2.50)
And the pH of the 5% slurry was 8.8.
~ 10.5 synthetic amorphous silicate as an abrasive. In this case, a 5% slurry having a pH lower than 8.8 has poor compatibility with fluorine and has a pH of 10.5.
If it is higher, an adverse effect is exerted on the flavor, resulting in a disadvantage that the feeling of use is lowered. The silicate has a primary average particle size of 0.01 to 0.5 μm and an aggregated particle size of 1.5 to 30 μm.
μm is preferably used. Further, the one having a BET specific surface area of 5 to 800 m ² / g is preferable. The method for producing the silicate is not particularly limited. For example, a water-soluble alkali metal silicate is charged in a reaction vessel in advance, and a water-soluble zirconium salt and a mineral acid are added thereto. When the obtained wet cake is dispersed in several times the amount of water and washed, the slurry p
A method of adjusting H can be adopted. The amount of the present abrasive in toothpaste is not necessarily limited, but is usually 1 to 50%, preferably 5 to 40% of the whole composition. The dentifrice composition of the present invention contains aluminum lactate as a component for preventing hypersensitivity. In this case, the amount of the solubilized component is 0.0% of the total composition.
It is preferably from 1 to 10%, particularly preferably from 0.1 to 5%.
If it is less than 0.01%, the expected effect may not be obtained, and if it exceeds 10%, the feeling of use may be reduced. Further, potassium nitrate may be added as a component for additionally improving the effect of preventing and treating hypersensitivity to 0.005 to 20%, particularly 0.1 to 7% of the total composition. . The dentifrice composition of the present invention comprises, in addition to the above silicate and aluminum lactate, an abrasive, a thickener, a binder,
Surfactants, sweeteners, preservatives, active ingredients, pigments, fragrances and the like can be blended, and these components can be mixed with water to produce. As the abrasive, it is possible to use in combination with one or more of the following in addition to the above silicate. That is, as such abrasives, silica-based abrasives such as silica gel, precipitated silica, igneous silica, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, water Aluminum oxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, magnesium triphosphate, zeolite, zirconium silicate, calcium triphosphate , Hydroxyapatite, fluoroapatite, calcium-deficient apatite, quaternary calcium phosphate, octacalcium phosphate, synthetic resin abrasives and the like. As the thickener, one or two or more of glycerin, sorbitol, propylene glycol, polyethylene glycol having a molecular weight of 200 to 6000, polyhydric alcohols such as reduced starch saccharified products and the like can be used. Examples of the binder include xanthan gum, sodium alginate, sodium polyacrylate, propylene glycol alginate, carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin, bentonite and the like. Inorganic binders and the like. Examples of the surfactant include anionic surfactants, cationic surfactants, nonionic surfactants, and the like. Specific examples include sodium lauryl sulfate, sodium N-lauroyltaurine, N-acyl sarcosinate,
α-olefin sodium sulfonate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-
Examples include hydroxyethyl imidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic, decaglyceryl laurate and the like. As sweeteners, sodium saccharin,
Preservatives such as aspartame, stevioside, stevia extract, paramethoxycinamic aldehyde, neohesperidyl dihydrochalcone, perillartin,
Examples thereof include parabens such as butylparaben and ethylparaben, paraoxybenzoic acid esters, and sodium benzoate. Various active ingredients include fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride and sodium monofluorophosphate, and water-soluble compounds such as potassium and sodium phosphates of orthophosphoric acid. Phosphate compounds, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, isopropylmethylphenol, chlorhexidine Salts, triclosan, biosol, cetylpyridinium chloride, azulene, glycyrrhetin, glycyrrhetinic acid,
Copper chlorophyllin sodium, chlorophyll, chelating phosphate compounds such as glycerophosphate, copper compounds such as copper gluconate, strontium chloride, berberine,
Hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, benzethonium chloride, sodium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, touki soft Extract, oak extract, chamomile, clove, rosemary, ogre, safflower and the like. As the fragrance, peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, Mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris Natural fragrances such as concrete, absolute peppermint, absolute rose, orange flower, etc., and processing of these natural fragrances (forehead cut, rear reservoir cut, fractionation, liquid-liquid extraction, essence, powdered fragrance, etc.) Fragrance, menthol, carvone,
Anethole, cineole, methyl salicylate, cinamic aldehyde, eugenol, 3,1-menthoxypropane-1,2-diol, thymol, linalool, linalool acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthane-3- Carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecalactone, hexanal, Ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine , Ethyl lactate, ethyl thioacetate, etc., and mixed flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. In addition, known perfume materials used for oral compositions can be used, and are not limited to the perfume of the examples. The amount of the perfume material is not particularly limited, but it is preferable that the above-mentioned perfume material is used in an amount of 0.000001 to 1% in the pharmaceutical composition. Moreover, it is preferable to use 0.1 to 2% as a flavoring perfume using the above-mentioned perfume material in a pharmaceutical composition. Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and the like. In addition, the compounding amount of these components can be made into a usual amount as long as the effect of the present invention is not hindered. EFFECT OF THE INVENTION The dentifrice composition of the present invention has the effect of preventing and treating hyperesthesia. EXAMPLES Hereinafter, the present invention will be described in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass percentage. Examples 1 to 4 and Comparative Examples 1 to 3 Using the abrasives shown in Table 1, dentifrice compositions having the compositions shown in Table 2 were prepared. Next, having a temporary pain at the time of rinsing with water after brushing the tooth, not having a rinsing with water, usually using a patient with hypersensitivity who is rinsing with lukewarm water as a panel, according to the following criteria and methods The effect of improving hyperesthesia was evaluated. The temperature of water used for water rinsing was 10 ° C. Table 2 shows the results. [Test Method] Hypersensitive individuals with the above-mentioned conditions were divided into groups of 5 each, and toothpastes of each composition shown in Table 2 were used twice a day (at wake-up and at bedtime) for one week. After one week, pain during water rinsing (10 ° C.) was evaluated according to the following criteria. The pain before the start of the test was one point of the following criteria in all panels. [Pain evaluation criteria] 1 point: very painful 2 points: considerably painful 3 points: slightly painful 4 points: slightly painful 5 points: no pain at all [Table 1] Note: Abrasives A to C have X-ray diffraction angles 2θ = 21 to 23 ° (d = 4.07 to 4.0) when baked at 900 ° C. for 1 hour.
9) and 2θ = 35-37 ° (d = 2.48-2.50)
Had a diffraction peak. Abrasives DF are
It had no diffraction peak. [Table 2] As shown in Table 2, it was found that the dentifrice composition containing the abrasive of the present invention and aluminum lactate significantly improved the pain of hypersensitive individuals. Example 4 Abrasive A 15% sodium monofluorophosphate 0.75 aluminum lactate 2.0 potassium nitrate 3.0 propylene glycol 3.0 carrageenan 0.8 hydroxymethylcellulose 0.4 sodium hydroxide 0.5 Glycerin 30 Sodium lauryl sulfate 0.5 Sodium saccharin 0.02 Fragrance 0.8 Purified water Balance 100.0% [Example 5] Abrasive B 12% Sodium monofluorophosphate 0.73 Aluminum lactate 3.0 potassium nitrate 5.0 tranexamic acid 1.0 propylene glycol 3.0 carrageenan 0.7 xanthan gum 0.6 glycerin 30 sodium 0.5 sodium lauryl sulfate hydroxide 0.9 sodium saccharin 0.02 perfume 0.8 purified water balance total 10 Example 6 Polishing Agent B 18% Sodium Monofluorophosphate 0.75 Aluminum Lactate 2.0 Potassium Nitrate 5.0 dl-Tocopherol Acetate 0.5 Propylene Glycol 3.0 Carrageenan 0.2 Hydroxy Methylcellulose 0.5 Xanthan gum 0.3 Sorbit 30 Sodium hydroxide 0.6 Sodium lauryl sulfate 1.8 Saccharin sodium 0.15 Fragrance 1.4 Purified water Balance 100.0% [Example 7] Abrasive C12 % Sodium fluoride 0.2 Aluminum lactate 2.0 Potassium nitrate 3.0 Triclosan 0.3 Propylene glycol 2.0 Polyethylene glycol 400 1.0 Carrageenan 0.7 Sodium carboxymethylcellulose 0.5 Sorbit 30 Hydroxide Thorium 0.5 1.2 Saccharin sodium 0.18 Perfume 1.1 Purified water balance Total 100.0% sodium lauryl sulfate [0038] Example 8 Sodium abrasive A 10% monofluorophosphate 0.75 aluminum lactate 5 2.0 Potassium nitrate 5.0 Propylene glycol 3.0 Carrageenan 0.8 Hydroxymethylcellulose 0.4 Sorbit 28 Sodium hydroxide 1.0 Sodium lauryl sulfate 1.5 Saccharin sodium 0.1 Fragrance 1.2 Purified water Balance 100.0% Example 9 Abrasive B 12% sodium monofluorophosphate 0.75 aluminum lactate 3.0 cetylpyridinium chloride 0.3 propylene glycol 3.0 disodium hydrogen phosphate 0.5 carrageenan 0.8 hydroxy Methylse Loin 0.4 sorbitol 34 1.0 Saccharin sodium 0.1 Perfume 1.2 Purified water balance Total 100.0% sodium 0.5 Sodium lauryl sulfate hydroxide [0040] Example 10 abrasive A 10% monofluorophosphate Sodium acidate 0.75 Aluminum lactate 2.0 Potassium nitrate 5.0 Sodium chloride 5.0 Propylene glycol 3.0 Carrageenan 0.6 Xanthan gum 0.6 Sorbit 35 Sodium hydroxide 0.5 Sodium lauryl sulfate 1.3 Saccharin sodium 0.15 Perfume 1.2 Purified water Balance: 100.0% Reference Example A zirconium-bonded synthetic amorphous silicate according to the present invention was produced by the following method. 150mm
In a reaction vessel equipped with a 20-L baffle provided with a stirrer having a φ turbine blade, 10% sodium silicate (Na ₂ O ·
3.14 SiO ₂ ) aqueous solution (10 kg) was added, the reaction temperature was maintained at 90 ° C., and sodium chloride (105 g) was added thereto, and further the zirconium oxychloride solution (ZrO ₂ : 21. 6%) and 10% sulfuric acid, and then 10% sulfuric acid until pH 7.0. Next, the resulting slurry is filtered,
The obtained wet cake was repulped. During this repulping, 10% sulfuric acid was added to adjust the slurry pH to 8.0. Then, it was filtered, dried and pulverized.

Continuation of front page    (72) Inventor Masato Arai             Rio, 1-3-7, Honjo, Sumida-ku, Tokyo             Incorporated (72) Inventor Keishu Ebine             Rio, 1-3-7, Honjo, Sumida-ku, Tokyo             Incorporated F term (reference) 4C083 AB032 AB171 AB211 AB272                       AB371 AB472 AC122 AC132                       AC301 AC302 AC622 AC782                       AC812 AC862 AD042 AD282                       AD352 AD662 CC41 EE38

Claims (1)

Claims: 1. An X-ray diffraction angle 2θ when zirconium is bonded as ZrO ₂ to SiO _{2 in} a range of 1.5 to 3.5 mass% with respect to SiO _{2 and} calcined at 900 ° C. for 1 hour = 21-23 °
(D = 4.07 to 4.09) and 2θ = 35 to 37 ° (d
= 2.48-2.50) and a synthetic amorphous silicate having a pH of 8.8-10.5 having a diffraction peak at 5% by mass of the slurry as an abrasive, and aluminum lactate was added. A dentifrice composition characterized by comprising: