KR101096501B1 - (-)-(1ｒ,2ｒ)-3-(3-디메틸아미노-1-에틸-2-메틸프로필)-페놀 하이드로클로라이드의 결정형 - Google Patents

(-)-(1ｒ,2ｒ)-3-(3-디메틸아미노-1-에틸-2-메틸프로필)-페놀 하이드로클로라이드의 결정형 Download PDF

Info

Publication number: KR101096501B1
Authority: KR; South Korea
Prior art keywords: methylpropyl; ethyl; dimethylamino; phenol hydrochloride; temperature
Prior art date: 2004-06-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

KR1020077002099A

Other languages

English (en)

Korean (ko)

Other versions

KR20070039929A (ko

Inventor

안드레아스 피셔

헬무트 부쉬만

미하엘 그루쓰

다그마 리쉬케

Original Assignee

그뤼넨탈 게엠베하

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-28

Filing date

2005-06-27

Publication date

2011-12-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101096501(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-06-27 Application filed by 그뤼넨탈 게엠베하 filed Critical 그뤼넨탈 게엠베하

2007-04-13 Publication of KR20070039929A publication Critical patent/KR20070039929A/ko

2011-12-20 Application granted granted Critical

2011-12-20 Publication of KR101096501B1 publication Critical patent/KR101096501B1/ko

2025-06-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hematology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

KR1020077002099A 2004-06-28 2005-06-27 (-)-(1ｒ,2ｒ)-3-(3-디메틸아미노-1-에틸-2-메틸프로필)-페놀 하이드로클로라이드의 결정형 Expired - Lifetime KR101096501B1 (ko)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP04015091A EP1612203B1 (en)	2004-06-28	2004-06-28	Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
EP04015091.4		2004-06-28
PCT/EP2005/006884 WO2006000441A2 (en)	2004-06-28	2005-06-27	Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Publications (2)

Publication Number	Publication Date
KR20070039929A KR20070039929A (ko)	2007-04-13
KR101096501B1 true KR101096501B1 (ko)	2011-12-20

Family

ID=34925507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1020077002099A Expired - Lifetime KR101096501B1 (ko)	2004-06-28	2005-06-27	(-)-(1ｒ,2ｒ)-3-(3-디메틸아미노-1-에틸-2-메틸프로필)-페놀 하이드로클로라이드의 결정형

Country Status (27)

Country	Link
US (16)	US20070213405A1 (da)
EP (2)	EP1612203B1 (da)
JP (1)	JP4990764B2 (da)
KR (1)	KR101096501B1 (da)
CN (1)	CN1997621B (da)
AR (2)	AR049949A1 (da)
AT (2)	ATE368639T1 (da)
AU (1)	AU2005256512B2 (da)
BR (2)	BRPI0512792A (da)
CA (1)	CA2572147C (da)
CY (2)	CY1106929T1 (da)
DE (2)	DE602004007905T2 (da)
DK (2)	DK1612203T3 (da)
EC (1)	ECSP17046065A (da)
ES (2)	ES2291780T3 (da)
HR (1)	HRP20110050T8 (da)
IL (1)	IL180373A (da)
MX (1)	MXPA06014741A (da)
NO (3)	NO338605B1 (da)
NZ (1)	NZ551605A (da)
PE (1)	PE20060372A1 (da)
PL (2)	PL1612203T3 (da)
PT (2)	PT1612203E (da)
RU (1)	RU2423345C2 (da)
SI (2)	SI1612203T1 (da)
WO (1)	WO2006000441A2 (da)
ZA (1)	ZA200700774B (da)

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KR20140053159A (ko)	2011-07-29	2014-05-07	그뤼넨탈 게엠베하	즉시 약물 방출을 제공하는 탬퍼-저항성 정제
RS56527B1 (sr)	2011-07-29	2018-02-28	Gruenenthal Gmbh	Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu
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2004
- 2004-06-28 PT PT04015091T patent/PT1612203E/pt unknown
- 2004-06-28 DE DE602004007905T patent/DE602004007905T2/de not_active Expired - Lifetime
- 2004-06-28 PL PL04015091T patent/PL1612203T3/pl unknown
- 2004-06-28 SI SI200430461T patent/SI1612203T1/sl unknown
- 2004-06-28 ES ES04015091T patent/ES2291780T3/es not_active Expired - Lifetime
- 2004-06-28 EP EP04015091A patent/EP1612203B1/en not_active Expired - Lifetime
- 2004-06-28 AT AT04015091T patent/ATE368639T1/de active
- 2004-06-28 DK DK04015091T patent/DK1612203T3/da active
2005
- 2005-06-27 CN CN2005800216611A patent/CN1997621B/zh not_active Expired - Fee Related
- 2005-06-27 AT AT05770026T patent/ATE496021T1/de active
- 2005-06-27 DE DE602005026031T patent/DE602005026031D1/de not_active Expired - Lifetime
- 2005-06-27 KR KR1020077002099A patent/KR101096501B1/ko not_active Expired - Lifetime
- 2005-06-27 WO PCT/EP2005/006884 patent/WO2006000441A2/en active Application Filing
- 2005-06-27 ES ES05770026T patent/ES2359504T3/es not_active Expired - Lifetime
- 2005-06-27 NZ NZ551605A patent/NZ551605A/en unknown
- 2005-06-27 JP JP2007518520A patent/JP4990764B2/ja not_active Expired - Lifetime
- 2005-06-27 PT PT05770026T patent/PT1799633E/pt unknown
- 2005-06-27 PL PL05770026T patent/PL1799633T3/pl unknown
- 2005-06-27 AU AU2005256512A patent/AU2005256512B2/en not_active Expired
- 2005-06-27 RU RU2007103297/04A patent/RU2423345C2/ru active
- 2005-06-27 HR HR20110050T patent/HRP20110050T8/xx unknown
- 2005-06-27 BR BRPI0512792-0A patent/BRPI0512792A/pt not_active Application Discontinuation
- 2005-06-27 MX MXPA06014741A patent/MXPA06014741A/es active IP Right Grant
- 2005-06-27 CA CA2572147A patent/CA2572147C/en not_active Expired - Lifetime
- 2005-06-27 SI SI200531252T patent/SI1799633T1/sl unknown
- 2005-06-27 BR BR122018014454A patent/BR122018014454B8/pt active IP Right Grant
- 2005-06-27 DK DK05770026.2T patent/DK1799633T3/da active
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Publication number	Publication date
US20210261492A1 (en)	2021-08-26
DK1799633T3 (da)	2011-03-28
AU2005256512B2 (en)	2011-05-19
WO2006000441A3 (en)	2006-05-04
AU2005256512A1 (en)	2006-01-05
SI1799633T1 (sl)	2011-05-31
JP2008504326A (ja)	2008-02-14
MXPA06014741A (es)	2007-02-12
ATE368639T1 (de)	2007-08-15
RU2423345C2 (ru)	2011-07-10
ES2291780T3 (es)	2008-03-01
NO343922B1 (no)	2019-07-08
DK1612203T3 (da)	2007-12-03
US20110294898A1 (en)	2011-12-01
US20180029976A1 (en)	2018-02-01
CY1106929T1 (el)	2012-09-26
AR116052A2 (es)	2021-03-25
BR122018014454B1 (pt)	2019-09-03
CY1111530T1 (el)	2015-08-05
PL1799633T3 (pl)	2011-06-30
EP1799633B1 (en)	2011-01-19
US20140011886A1 (en)	2014-01-09
JP4990764B2 (ja)	2012-08-01
US20160122287A1 (en)	2016-05-05
US20190062263A1 (en)	2019-02-28
NO338605B1 (no)	2016-09-12
CA2572147A1 (en)	2006-01-05
HRP20110050T1 (hr)	2011-02-28
US20120302643A1 (en)	2012-11-29
WO2006000441A2 (en)	2006-01-05
US20090186947A1 (en)	2009-07-23
CN1997621A (zh)	2007-07-11
NO20171103A1 (no)	2007-01-24
IL180373A0 (en)	2007-06-03
SI1612203T1 (sl)	2007-12-31
NZ551605A (en)	2010-01-29
AR049949A1 (es)	2006-09-20
US20180230082A1 (en)	2018-08-16
US20140296346A1 (en)	2014-10-02
ECSP17046065A (es)	2018-11-30
PT1612203E (pt)	2007-08-20
PT1799633E (pt)	2011-03-07
BRPI0512792A (pt)	2008-04-08
PL1612203T3 (pl)	2007-12-31
HRP20110050T8 (en)	2011-03-31
EP1612203A1 (en)	2006-01-04
US20230174458A1 (en)	2023-06-08
DE602005026031D1 (de)	2011-03-03
DE602004007905T2 (de)	2008-05-08
US20200102261A1 (en)	2020-04-02
RU2007103297A (ru)	2008-08-10
ATE496021T1 (de)	2011-02-15
EP1799633A2 (en)	2007-06-27
US20170166515A1 (en)	2017-06-15
EP1612203B1 (en)	2007-08-01
NO20160914A1 (no)	2007-01-24
ES2359504T3 (es)	2011-05-24
DE602004007905D1 (de)	2007-09-13
ZA200700774B (en)	2008-09-25
US7994364B2 (en)	2011-08-09
KR20070039929A (ko)	2007-04-13
NO20070162L (no)	2007-01-24
BR122018014454B8 (pt)	2021-07-27
NO341239B1 (no)	2017-09-25
US20200385334A1 (en)	2020-12-10
IL180373A (en)	2012-05-31
US20070213405A1 (en)	2007-09-13
CN1997621B (zh)	2011-06-15
PE20060372A1 (es)	2006-05-08
CA2572147C (en)	2012-10-30
US20100160447A1 (en)	2010-06-24

Publication	Publication Date	Title
KR101096501B1 (ko)	2011-12-20	(-)-(1ｒ,2ｒ)-3-(3-디메틸아미노-1-에틸-2-메틸프로필)-페놀 하이드로클로라이드의 결정형
NO340520B1 (no)	2017-05-02	Krystallform av asenapinmaleat, fremgangsmåte for fremstilling av slike, farmasøytiske sammensetninger omfattende slike samt anvendelse av slike for behandling av sykdom
AU2023202085A1 (en)	2023-05-04	Polymorphic forms of RAD1901-2HCL
US20120142693A1 (en)	2012-06-07	Crystalline compound of 7-[(3r)-3-amino-1-oxo-4-(2, 4, 5-trifluorphenyl)butyl]-5, 6, 7, 8-tetrahydro-3-(tri fluormethyl)-1, 2, 4 -triazolo[4,3-a]pyrazin
WO2016023906A1 (en)	2016-02-18	A crystalline form of sofosbuvir
WO2006020348A2 (en)	2006-02-23	Polymorphs of atomoxetine hydrochloride
WO2019166962A1 (en)	2019-09-06	Deutetrabenazine polymorphs and methods for their preparation

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