[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK1612203T3 - Krystallinske former af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenolhydrochlorid - Google Patents

Krystallinske former af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenolhydrochlorid

Info

Publication number
DK1612203T3
DK1612203T3 DK04015091T DK04015091T DK1612203T3 DK 1612203 T3 DK1612203 T3 DK 1612203T3 DK 04015091 T DK04015091 T DK 04015091T DK 04015091 T DK04015091 T DK 04015091T DK 1612203 T3 DK1612203 T3 DK 1612203T3
Authority
DK
Denmark
Prior art keywords
methylpropyl
dimethylamino
ethyl
crystalline forms
phenol hydrochloride
Prior art date
Application number
DK04015091T
Other languages
English (en)
Inventor
Andreas Dr Fischer
Helmut Dr Buschmann
Michael Dr Gruss
Dagmar Lischke
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1612203(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK1612203T3 publication Critical patent/DK1612203T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10Separation; Purification; Stabilisation; Use of additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK04015091T 2004-06-28 2004-06-28 Krystallinske former af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenolhydrochlorid DK1612203T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04015091A EP1612203B1 (en) 2004-06-28 2004-06-28 Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Publications (1)

Publication Number Publication Date
DK1612203T3 true DK1612203T3 (da) 2007-12-03

Family

ID=34925507

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04015091T DK1612203T3 (da) 2004-06-28 2004-06-28 Krystallinske former af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenolhydrochlorid
DK05770026.2T DK1799633T3 (da) 2004-06-28 2005-06-27 Krystalformer af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol-hydrochlorid til anvendelse som aktivt indholdsstof i farmaceutiske sammensætninger

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK05770026.2T DK1799633T3 (da) 2004-06-28 2005-06-27 Krystalformer af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol-hydrochlorid til anvendelse som aktivt indholdsstof i farmaceutiske sammensætninger

Country Status (27)

Country Link
US (16) US20070213405A1 (da)
EP (2) EP1612203B1 (da)
JP (1) JP4990764B2 (da)
KR (1) KR101096501B1 (da)
CN (1) CN1997621B (da)
AR (2) AR049949A1 (da)
AT (2) ATE368639T1 (da)
AU (1) AU2005256512B2 (da)
BR (2) BR122018014454B8 (da)
CA (1) CA2572147C (da)
CY (2) CY1106929T1 (da)
DE (2) DE602004007905T2 (da)
DK (2) DK1612203T3 (da)
EC (1) ECSP17046065A (da)
ES (2) ES2291780T3 (da)
HR (1) HRP20110050T8 (da)
IL (1) IL180373A (da)
MX (1) MXPA06014741A (da)
NO (3) NO338605B1 (da)
NZ (1) NZ551605A (da)
PE (1) PE20060372A1 (da)
PL (2) PL1612203T3 (da)
PT (2) PT1612203E (da)
RU (1) RU2423345C2 (da)
SI (2) SI1612203T1 (da)
WO (1) WO2006000441A2 (da)
ZA (1) ZA200700774B (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
SI1612203T1 (sl) * 2004-06-28 2007-12-31 Gruenenthal Chemie Kristalne oblike (-)-(1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)-fenol hidroklorida
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
DE102007019417A1 (de) * 2007-04-23 2008-11-13 Grünenthal GmbH Tapentadol zur Schmerzbehandlung bei Arthrose
CN104447360B (zh) * 2007-12-07 2017-04-12 格吕伦塔尔有限公司 (1r,2r)‑3‑(3‑二甲基氨基‑1‑乙基‑2‑甲基‑丙基)‑苯酚的结晶变体
NZ586792A (en) 2008-01-25 2012-09-28 Gruenenthal Chemie Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
US20100272815A1 (en) * 2009-04-28 2010-10-28 Actavis Group Ptc Ehf Amorphous form of tapentadol hydrochloride
PL2456424T3 (pl) 2009-07-22 2013-12-31 Gruenenthal Gmbh Stabilizowana przed utlenianiem odporna na naruszenie postać dawkowania
US10080721B2 (en) 2009-07-22 2018-09-25 Gruenenthal Gmbh Hot-melt extruded pharmaceutical dosage form
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
EP2566461A2 (de) 2010-05-05 2013-03-13 Ratiopharm GmbH Festes tapentadol in nicht-kristalliner form
RS61515B1 (sr) * 2010-07-23 2021-03-31 Gruenenthal Gmbh Soli ili kokristali 3-(3-dimetilamino-1-etil-2-metil-propil)-fenola
BR112013005194A2 (pt) 2010-09-02 2016-05-03 Gruenenthal Gmbh forma de dosagem resistente à violação compreendendo sal inorgânico
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
WO2012051246A1 (en) 2010-10-12 2012-04-19 Ratiopharm Gmbh Tapentadol hydrobromide and crystalline forms thereof
WO2012119728A1 (en) * 2011-03-04 2012-09-13 Grünenthal GmbH Parenteral administration of tapentadol
EA033171B1 (ru) 2011-03-04 2019-09-30 Грюненталь Гмбх Полутвёрдая фармацевтическая композиция на водной основе, содержащая тапентадол
HUE046557T2 (hu) 2011-03-04 2020-03-30 Gruenenthal Gmbh Tapentadolt tartalmazó vizes gyógyszerészeti készítmény szájon át alkalmazásra
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
WO2013111161A2 (en) * 2012-01-10 2013-08-01 Msn Laboratories Limited Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
AU2013248351B2 (en) 2012-04-18 2018-04-26 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CZ304576B6 (cs) * 2012-07-24 2014-07-16 Zentiva, K.S. Oxalát TAPENTADOLU a způsob jeho přípravy
CN102924303B (zh) * 2012-10-31 2013-11-20 合肥市新星医药化工有限公司 盐酸他喷他多晶型c及其制备方法和应用
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
AR096439A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido que contiene una o más partículas
EP2808319A1 (en) 2013-05-31 2014-12-03 Arevipharma GmbH 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
EP2845625A1 (en) * 2013-09-04 2015-03-11 Grünenthal GmbH Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome
US9599565B1 (en) * 2013-10-02 2017-03-21 Ondax, Inc. Identification and analysis of materials and molecular structures
WO2015071248A1 (en) 2013-11-15 2015-05-21 Synthon B.V. Abuse-proofed extended release pharmaceutical composition comprising tapentadol
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
GB2523089A (en) * 2014-02-12 2015-08-19 Azad Pharmaceutical Ingredients Ag Stable polymorph form B of tapentadol hydrochloride
US20150320690A1 (en) 2014-05-12 2015-11-12 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EP3148512A1 (en) 2014-05-26 2017-04-05 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
JP6923447B2 (ja) 2015-03-27 2021-08-18 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング タペンタドールの非経口投与のための安定な製剤
CA2983642A1 (en) 2015-04-24 2016-10-27 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
EP3653599B1 (en) 2016-04-19 2022-12-14 ratiopharm GmbH Crystalline tapentadol phosphate
KR20190057349A (ko) 2016-09-23 2019-05-28 그뤼넨탈 게엠베하 타펜타돌의 비경구 투여용 안정한 제제
WO2018153947A1 (en) 2017-02-23 2018-08-30 Grünenthal GmbH Tapentadol as local anesthetic
CA3196954A1 (en) 2020-11-03 2022-05-12 Josep Bassaganya-Riera Crystalline forms of piperazine-1,4-diylbis((6-(1h-benzoi[d]imidazo-2-yl)pyridin-2yl)methanone) as lancl2 modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
EA003754B1 (ru) * 1996-08-14 2003-08-28 Джи. Ди. Сирл Энд Ко. 4-[5-метил-3-фенилизоксазол-4-ил] бензолсульфонамид
CN100338028C (zh) * 2000-10-31 2007-09-19 山道士有限公司 盐酸文拉法辛的晶形
US20050176790A1 (en) * 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
US7208520B2 (en) * 2001-09-13 2007-04-24 Kissei Pharmaceutical Co., Ltd. Crystals of hydroxynorephedrine derivative
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
SI1612203T1 (sl) * 2004-06-28 2007-12-31 Gruenenthal Chemie Kristalne oblike (-)-(1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)-fenol hidroklorida

Also Published As

Publication number Publication date
NO20171103A1 (no) 2007-01-24
ECSP17046065A (es) 2018-11-30
NO343922B1 (no) 2019-07-08
CA2572147C (en) 2012-10-30
PE20060372A1 (es) 2006-05-08
CN1997621A (zh) 2007-07-11
US20070213405A1 (en) 2007-09-13
US7994364B2 (en) 2011-08-09
JP4990764B2 (ja) 2012-08-01
ZA200700774B (en) 2008-09-25
DE602004007905D1 (de) 2007-09-13
RU2423345C2 (ru) 2011-07-10
US20180029976A1 (en) 2018-02-01
AR049949A1 (es) 2006-09-20
US20090186947A1 (en) 2009-07-23
CY1111530T1 (el) 2015-08-05
MXPA06014741A (es) 2007-02-12
KR101096501B1 (ko) 2011-12-20
PL1799633T3 (pl) 2011-06-30
ATE496021T1 (de) 2011-02-15
AU2005256512B2 (en) 2011-05-19
US20100160447A1 (en) 2010-06-24
ES2291780T3 (es) 2008-03-01
US20230174458A1 (en) 2023-06-08
US20160122287A1 (en) 2016-05-05
IL180373A0 (en) 2007-06-03
RU2007103297A (ru) 2008-08-10
EP1612203B1 (en) 2007-08-01
US20200102261A1 (en) 2020-04-02
HRP20110050T8 (en) 2011-03-31
ATE368639T1 (de) 2007-08-15
NO341239B1 (no) 2017-09-25
BR122018014454B1 (pt) 2019-09-03
PT1799633E (pt) 2011-03-07
DK1799633T3 (da) 2011-03-28
JP2008504326A (ja) 2008-02-14
KR20070039929A (ko) 2007-04-13
AU2005256512A1 (en) 2006-01-05
US20210261492A1 (en) 2021-08-26
BRPI0512792A (pt) 2008-04-08
PT1612203E (pt) 2007-08-20
EP1612203A1 (en) 2006-01-04
CN1997621B (zh) 2011-06-15
EP1799633B1 (en) 2011-01-19
US20200385334A1 (en) 2020-12-10
AR116052A2 (es) 2021-03-25
US20110294898A1 (en) 2011-12-01
DE602005026031D1 (de) 2011-03-03
EP1799633A2 (en) 2007-06-27
NO20070162L (no) 2007-01-24
HRP20110050T1 (hr) 2011-02-28
PL1612203T3 (pl) 2007-12-31
CA2572147A1 (en) 2006-01-05
WO2006000441A3 (en) 2006-05-04
US20140296346A1 (en) 2014-10-02
CY1106929T1 (el) 2012-09-26
NO338605B1 (no) 2016-09-12
NO20160914A1 (no) 2007-01-24
DE602004007905T2 (de) 2008-05-08
US20120302643A1 (en) 2012-11-29
US20170166515A1 (en) 2017-06-15
WO2006000441A2 (en) 2006-01-05
US20180230082A1 (en) 2018-08-16
NZ551605A (en) 2010-01-29
SI1612203T1 (sl) 2007-12-31
US20140011886A1 (en) 2014-01-09
ES2359504T3 (es) 2011-05-24
US20190062263A1 (en) 2019-02-28
SI1799633T1 (sl) 2011-05-31
BR122018014454B8 (pt) 2021-07-27
IL180373A (en) 2012-05-31

Similar Documents

Publication Publication Date Title
DK1612203T3 (da) Krystallinske former af (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenolhydrochlorid
DK3210965T3 (da) Fremgangsmåde til fremstilling af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
DK2049464T3 (da) Fremstilling af 3-[(1R,2R)-3-(dimethylamino)-1ethyl-2-methylpropyl]phenol
NO2017007I2 (no) Eluxadoline eller en farmasøytisk akseptabel enantiomer, diastereomer, rasemat eller salt derav
ATE477257T1 (de) Piperidinylamino-thienoä2,3-dü- pyrimidinverbindungen
DK1786403T3 (da) Mod misbrug sikret, oral indgivelsesform indeholdende (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
DK1817309T3 (da) Acetamidforbindelser som fungicider
ITTO20040563A1 (it) Calzature asimmetriche, particolarmente per il gioco del golf
NO20040218L (no) Fremgangsmåte for ad hoc buffer
DK3173400T3 (da) Medikamenter, der indeholder krystallinske modifikationer af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
ATE383768T1 (de) Köderstationen
DE602005023972D1 (de) Vereinfachte wafer-ausrichtung
NL1028193A1 (nl) Farmaceutisch werkzame verbindingen.
NL1030382A1 (nl) Gesubstitueerde N-sulfonylaminobenzyl-2-fenoxyaceetamide verbindingen.
DK1853576T3 (da) Krystallinsk base af trans-1-((1R,3S)-6-chlor-3-phenylindan-1-yl)-3,3-dimethylpiperazin
DK1727782T3 (da) Fremgangsmåde til fremstilling af aminophenolforbindelser
FI20045145A0 (fi) Sijainninmääritysvastaanotin
AP2007003934A0 (en) Hydrochloride of 4-ÄÄ4-ÄÄ4-(2-cyanoethenyl)-2,6-dimethylphenylÜaminoÜ-2-pyrimidinylÜaminoÜbenzonitrile
CY2004010I2 (el) Phenyl carbamate
ES1058726Y (es) Repartidor digital para telecomunicaciones.
ITPD20040243A1 (it) Inserto per sottotacchi.
FI6536U1 (fi) Istutuskuokka
ES1059186Y (es) Caseta para sanitarios publicos.
ES1058525Y (es) Cabezal para friegasuelos.
ATA80062005A (de) Brille, insbesondere für den schiesssport