KR101023041B1 - Cosmetic composition for moisturizing effect on the skin - Google Patents

Abstract

The present invention relates to a cosmetic composition for moisturizing the skin, and in detail, at least one of inositol, betaine, taurine homarine, and erythritol is stabilized with nanoliposomes. It relates to a skin moisturizing cosmetic composition formed excellent skin penetration effect so as to improve the skin moisturizing effect to the skin stratum corneum as well as the skin stratum corneum.

Osmolite, skin moisture, cosmetic

Description

Cosmetic composition for skin moisturizing {Cosmetic composition for moisturizing effect on the skin}

The present invention relates to a cosmetic composition for moisturizing the skin, and in detail, one or more of inositol, betaine, taurine homarine, and erythritol are collected in nanoliposomes. It relates to a skin moisturizing cosmetic composition formed excellent skin penetration effect so as to improve the skin moisturizing effect to the skin stratum corneum as well as the skin stratum corneum.

Skin is the organ that protects the human body by being located at the outermost part of the body. It prevents the loss of water and electrolyte in our body and protects it from the ingress of foreign objects. The skin is divided into epidermal, dermal and subcutaneous fat layers. The epidermal layer is composed of keratinocytes. The outermost stratum corneum of the epidermal layer plays a very important role in the transmission of the substance.

The epidermis is composed of a basal layer, a pole layer, a granule layer and a stratum corneum. The stratum corneum is composed of keratinocytes and intercellular lipids, and the stratum corneum prevents the loss of moisture to the outside and also has the proper moisture to function properly. The skin barrier, located in the stratum corneum, consists of ceramide, fatty acids and cholesterol, which inhibits the penetration of foreign substances and prevents transepidermal water loss (TEWL). In addition, natural moisturizing factor (NMF) is known to play an important role in moisturizing the skin because it exists in the stratum corneum.

The moisture content of the epidermal layer is about 70% in the basal and polar layers, 30-50% in the granular layer and 15-30% in the stratum corneum (Journal of Investigative Dermatology, 116, 434442, 2001). In other words, the water content in the epidermis is gradually decreasing to the upper part of the skin water gradient, and the skin gradient is subject to continuous osmotic stress.

In addition, since the skin exists in the outermost layer of the human body, it is chronically exposed to air pollution, dry environment, ultraviolet light, wind, and chemicals. This condition exposes the skin to continuous osmotic stress, facilitating drier skin.

Recently, as the number of people with dry skin increases, the need for a moisturizer is increasing. Conventionally, when a formulation containing a skin lipid component as a skin moisturizer is used to restore and strengthen skin barriers, a moisturizer is developed by applying a natural moisturizing factor or polyols such as glycerin and butylene glycol, and keratinocytes. There are many ways to promote differentiation and develop skin moisturizers. However, as long as the moisture is continuously lost due to the external environment, the existing moisturizer has a great difficulty in maintaining skin moisture for a long time.

Thus, the present inventors studied a cosmetic composition that prevents moisture drying of the skin by using osmorite, and as a result, by preparing a cosmetic stabilized with nanoliposomes at least one of inositol, betaine, taurine, homarin, erythritol When applied to human skin, not only the moisture content increases not only in the stratum corneum but also in the dermis layer, it is confirmed that the moisture content persists for a long time, thereby completing the present invention.

In order to solve the above problems, the present invention may include the following means.

Skin moisturizing cosmetic composition according to the present invention comprises one or more components selected from inositol, betaine, taurine, homarin, erythritol.

According to another embodiment of the present invention, one or two or more components selected from inositol, betaine, taurine, homarin, and erythritol are contained in an amount of 0.1 wt% to 20.0 wt% based on the total weight of the nanoliposomes. do.

According to another embodiment of the present invention, the nanoliposome is characterized in that it contains 0.1% to 20.0% by weight in the cosmetic composition.

According to another embodiment of the present invention, the cosmetic composition is selected from the group consisting of softener, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray and powder It is characterized by having a formulation.

The cosmetics are prepared by stabilizing one or more of inositol, betaine, taurine, homarin, and erythritol with nanoliposomes. It can be seen that the skin penetration effect is greatly increased by being collected in, especially when the mixture of osmolite is used, the skin moisturization is greatly improved.

Hereinafter, the present invention will be described in detail.

In order to achieve the above object, the cosmetic composition according to the present invention contains a complex in which at least one of inositol, betaine, taurine, homarin and erythritol is stabilized with nanoliposomes as an active ingredient.

Inositol, the active ingredient of the present invention, is a type of sugar related to glucose. It is naturally produced by the body and is contained in fruits and vegetables. The chemical formula of inositol is C ₆ O ₆ H ₁₂ and is a hexavalent alcohol. The inositol is an essential metabolite of eukaryotic organisms, is a major component of membrane phospholipids, is involved in signal transduction and enzyme activity, and is known to be effective in anticancer activity and immune strengthening.

Betaine, the active ingredient of the present invention, is an amino acid having three methyl groups, and is widely used as a sweetener in food additives, and effects such as lowering blood pressure, strengthening musculoskeletal, promoting liver recovery, and preventing anemia are known.

Taurine, which is an active ingredient of the present invention, is a kind of amino acid and is widely distributed in various plants and animals. The benefits of taurine are known to help detoxify the liver, help the body recover from fatigue, promote bile secretion, reduce cholesterol, and prevent heart disease.

Homarin, an active ingredient of the present invention, has a structure similar to betaine and is relatively contained in the muscles and intestines of mollusks and arthropods, and is known to be effective in preventing hypertension and restoring liver function.

Erythritol used as an active ingredient in the present invention is a natural saccharide sugar existing in nature as a natural sweetener present in nature contained in fermented foods such as wine, cheese and fruits, such as mushrooms and melons, commercially glucose Fermented with yeast is produced.

The inositol, betaine, taurine, homarin and erythritol are known as a kind of osmolite, and the osmolite is an organic molecule having a low molecular weight composed of polyhydric alcohol, free amino acid, urea or derivatives thereof. The osmolite is present in bacteria, plants and animals to allow cells to maintain homeostasis without being affected by changing external environmental conditions. In other words, it plays a role of protecting the cells to survive even in areas with severe osmotic pressure or strong UV rays, such as tidal zones such as deserts and estuaries.

In particular, the most important function of osmolite is to maintain normal cell volume without losing water even under changing external conditions. In general, when a cell is exposed to a hypotonic solution, external water enters the cell to expand the cell, and the expanded cell undergoes cell lysis. In contrast, when the cells are exposed to a hypertonic solution, cell shrinkage occurs because water inside the cells flows out.

Therefore, the cells utilize osmolite as a defense against osmotic stress, and when the cells are exposed to the storage solution, the cells are released to the outside of the cells, and when the cells are exposed to the hypertonic solution, Osmolite may be introduced into cells or increased intracellular synthesis to inhibit cell contraction.

Therefore, by incorporating at least one of the inositol, betaine, taurine, homarin and erythritol in the cosmetic composition to maintain the normal cell volume without losing moisture of the skin, it is possible to continuously improve the skin moisturizing ability for a long time, As can be seen in the experimental example below, when all of the inositol, betaine, taurine, homarin and erythritol were mixed and included in the cosmetic composition according to the present invention, it was confirmed that the skin moisturizing effect could be continuously improved and maintained for a long time. .

On the other hand, the present invention is one or more components of the inositol, betaine, taurine, homarin and erythritol can easily penetrate not only the keratin of the skin but also to the dermis, the skin moisturizing effect can be continuously improved and maintained for a long time I could confirm that.

One or two or more components selected from the inositol, betaine, taurine, homarin and erythritol are suitably contained in an amount of 0.1 to 20.0% by weight based on the total weight of the nanoliposomes, more preferably 4 to 12% by weight. The content of the nanoliposomes stabilized with one or two or more components selected from inositol, betaine, taurine, homarin and erythritol is preferably 0.1 to 20.0 wt% based on the total weight of the cosmetic composition. When the content of the nanoliposome is less than 0.1% by weight shows little efficacy of the component, when the content of more than 20% by weight is because the increase in the effect of the increase of the content is insignificant and there is a problem in the stability of the formulation.

On the other hand, the weight ratio when two or more components selected from inositol, betaine, taurine, homarin and erythritol may be formed in the nanoliposomes may be variously formed, but preferably mixed in the same weight ratio.

As used herein, the term "nanoliposomes" refers to liposomes having an average particle diameter of 1-100 nm as having the form of conventional liposomes. According to a preferred embodiment of the present invention, the average particle diameter of the nanoliposomes is 30-70 nm. When the average particle diameter of the nanoliposomes exceeds 70 nm, the improvement of skin penetration and the stability of formulation is very weak among the technical effects to be achieved in the present invention.

Nanoliposomes of the present invention may be formed by a mixture comprising one or two or more components selected from inositol, betaine, taurine, homarin and erythritol, polyols, surfactants, phospholipids, fatty acids and water.

The polyol used in the nanoliposome of the present invention is not particularly limited, and preferably propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methyl propane diol, isoprene glycol, pentylene glycol, ziitol and sorbitol And most preferably propylene glycol. The amount used is 10-80% by weight, preferably 30-70% by weight based on the total weight of nanoliposomes.

Surfactants used in the preparation of the nanoliposomes of the present invention may be any known in the art, for example, anionic surfactants, cationic surfactants, amphoteric surfactants and nonionic surfactants may be used. , Preferably anionic surfactants and nonionic surfactants are used. Specific examples of anionic surfactants include alkylacylglutamate, alkylphosphates, alkyllactylates, dialkylphosphates, trialkylphosphates, and the like. Specific examples of nonionic surfactants include alkoxylated alkyl ethers, alkoxylated alkyl esters, alkylpolyglycosides, polyglyceryl esters, sugar esters, and the like. Most preferably, polysorbates belonging to the nonionic surfactant are used. The amount of the surfactant is generally 0.1-10% by weight, preferably 0.5-5.0% by weight relative to the total weight of the nanoliposomes.

Phospholipids, another component used in the preparation of the nanoliposomes of the present invention, are used as amphoteric lipids, including natural phospholipids (eg, egg yolk lecithin or soy lecithin, sphingomyelin) and synthetic phospholipids (eg dipalmitoyl). Phosphatidylcholine or hydrogenated lecithin), preferably lecithin. In the preparation of the nanoliposomes of the present invention, the amount of lecithin is 0.5 to 20% by weight, preferably 2 to 8% by weight based on the total weight of the nanoliposomes.

The fatty acids used in the preparation of the nanoliposomes of the present invention are higher fatty acids, preferably saturated or unsaturated fatty acids of the C12-22 alkyl chain, such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and linoleic acid. Include. The amount used is 0.05-3.0% by weight, preferably 0.1-1.0% by weight relative to the total weight of nanoliposomes.

Water used for the preparation of the nanoliposomes of the present invention is generally deionized distilled water, the amount of which is used is 5.0-40% by weight relative to the total weight of nanoliposomes.

The preparation of the nanoliposomes can be accomplished through various methods known in the art, but most preferably, a mixture comprising the above components is applied to a high pressure homogenizer. The preparation of nanoliposomes by high pressure homogenizer can be carried out under various conditions (eg, pressure, frequency, etc.) according to the desired particle size. Preferably, 1-5 times of high pressure homogenizer under 600-1200 bar pressure is carried out. Nanoliposomes are prepared by passing them through. The nanoliposome system thus prepared has the advantage of maximizing the skin penetration effect by dissolving various types of poorly soluble substances and stabilizing unstable substances.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to nanoliposomes including osmolite as active ingredients, and include, for example, conventional agents such as stabilizers, solubilizers, vitamins, pigments and perfumes. Adjuvants, and carriers.

The cosmetic composition according to the present invention may be prepared in any formulation conventionally manufactured in the art, for example, softening longevity, astringent longevity, nourishing longevity, eye cream, nourishing cream, massage cream, cleansing cream, cleansing The foam, cleansing water, powder, essence, pack and the like is not particularly limited, and may be prepared according to the formulation or purpose of use of the cosmetic.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident. Compounding amount is shown by weight%.

Experimental Example 1 Effects of Inositol, Betaine, Taurine, Homarin, and Erythritol on Fault Stress

In order to measure the effect of inhibiting cell contraction in hypertonic solution using the inositol, betaine, taurine, homarin, erythritol as the active ingredient was performed as follows.

HaMat cells, keratinocytes, 100 μM each of osmolite, inositol, betaine, taurine, homarin, and erythritol, and 20 μM each of the inositol, betaine, taurine, homarin, and erythritol were mixed with DMEM (Dulbecco's). Incubated for 24 hours at 37 ℃, 5% CO ₂ conditions in modified Eagle's medium) medium, then replaced with medium containing NaCl (400 mosmol per L) for 16 hours. After that, the medium was replaced with osmorite again and cultured for 48 hours. After incubation, 5 mg / ml yellow tetrazolium salt (MTT) solution was added, and after 4 hours, the yellow tetrazolium salt solution was removed and dissolved for 10 minutes with dimethyl sulfoxide (DMSO) spectrophotometer (Molecular Devices, USA) Absorbance of 570 nm was measured using a. Negative controls were treated with nothing, and positive controls were treated with hypertonic medium. The results of this experiment are shown in Table 1 below.

sample Cell survival rate (%) Negative Control 100.0 Positive control group 5.3 Inositol 25.1 Betaine 30.1 Taurine 28.8 Homarin 25.2 Erythritol 28.9 Mixed solution 91.8

As can be seen in Table 1, it was found that each osmolite has a protective action against stress of the hypertonic solution, and in particular, it was confirmed that the osmolite had the best effect in the mixed solution mixed with all the osmolite. .

Experimental Example 2 Effects of Osmorite According to UVB Irradiation

UVB is a representative factor causing oxidative stress. Oxidative stress produces hydrogen peroxide (H ₂ O ₂ ) (Curr Probl Dermatol, 29, 114-127, 2001), which causes a response similar to the effect of cell contraction caused by hypertonic stress (Science, 274, 1194-). 1197, 1996). Therefore, the effect of inhibiting cell contraction caused by UVB irradiation was measured using osmolite.

HaMat cells, keratinocytes, 100 μM each of osmolite, inositol, betaine, taurine, homarin, and erythritol, and 20 μM each of the inositol, betaine, taurine, homarin, and erythritol were mixed with DMEM (Dulbecco's). modified Eagle's medium) was incubated for 24 hours at 37 ℃, 5% CO ₂ conditions. Thereafter, the medium was replaced with PBS (phosphate buffered saline), 120mJ per cm ² of UVB (Oriel Solar UV Stimulator, Germany) was irradiated, and then incubated for 48 hours in a medium containing osmolite again. After incubation, 5 mg / ml yellow tetrazolium salt (MTT) solution was added, and after 4 hours, the yellow tetrazolium salt solution was removed and dissolved for 10 minutes with dimethyl sulfoxide (DMSO) spectrophotometer (Molecular Devices, USA) Absorbance of 570 nm was measured using a. The results are shown in Table 2 below. Negative controls were treated with nothing, and positive controls were UVB irradiated. The results of the experiment are shown in Table 2 below.

sample Cell survival rate (%) Negative Control 100.0 Positive control group 7.2 Inositol 29.1 Betaine 25.5 Taurine 26.2 Homarin 27.0 Erythritol 30.9 Mixed solution 92.6

As a result of the experiment, it can be seen that each osmolite has an effect of inhibiting cell contraction caused by UVB irradiation, and particularly, it is confirmed that the osmolite has the best effect in the sample mixed with all Could.

Preparation Examples 1 to 6 Preparation of Nanoliposomes Containing Osmolite

 To prepare a nano liposome with the composition and content of the following Table 3, First, add phase B to the phase A of Table 3, wet it uniformly, then add phase C, and then heat mixed to 70 ~ 80 ℃ . The solution was passed through a high pressure homogenizer 2 to 4 times under conditions of 600 to 1000 bar, and cooled to obtain stabilized (captured) nanoliposomes having a particle size of 30 to 70 nm in diameter.

Prize ingredient Preparation Example 1 Preparation Example 2 Preparation Example 3 Production Example 4 Preparation Example 5 Preparation Example 6 A glycerin To 100 To 100 To 100 To 100 To 100 To 100 B Hydrogenated lecithin 5.0 5.0 5.0 5.0 5.0 5.0 Liquid paraffin 1.0 1.0 1.0 1.0 1.0 1.0 Squalane 1.0 1.0 1.0 1.0 1.0 1.0 Dimethicone 1.0 1.0 1.0 1.0 1.0 1.0 Isopropyl myristate 1.0 1.0 1.0 1.0 1.0 1.0 Sodium Stearoyl Lactate 0.5 0.5 0.5 0.5 0.5 0.5 Polysorbate-80 0.5 0.5 0.5 0.5 0.5 0.5 Stearic acid 0.5 0.5 0.5 0.5 0.5 0.5 C Inositol 4.0 20.0 - - - - Betaine 4.0 - 20.0 - - - Taurine 4.0 - - 20.0 - - Homarin 4.0 - - - 20.0 - Erythritol 4.0 - - - - 20.0 Potassium hydroxide Quantity Quantity Quantity Quantity Quantity Quantity Purified water 5.0 5.0 5.0 5.0 5.0 5.0

[Manufacture example 7]

Table 4 shows a cosmetic composition containing osmolite stabilized with the nanoliposome prepared above in the form of nutrition cream having a composition ratio, a cosmetic composition containing osmolite and a cosmetic composition not containing osmolite or nanoliposome Prepared.

ingredient Example 1
(weight%) Example 2 (% by weight) Example 3 (% by weight) Example 4 (% by weight) Example 5
(weight%) Example 6
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Preparation Example 1 10.0 - - - - - - - Preparation Example 2 - 10.0 - - - - - - Preparation Example 3 - - 10.0 - - - - - Production Example 4 - - - 10.0 - - - - Preparation Example 5 - - - - 10.0 - - - Preparation Example 6 - - - - - 10.0 - - Inositol - - - - - - 0.4 - Betaine - - - - - - 0.4 - Taurine - - - - - - 0.4 - Homarin - - - - - - 0.4 - Erythritol - - - - - - 0.4 - glycerin 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Liquid paraffin 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 Polysorbate 60 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Sorbitan sesquirololeate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Squalane 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Beeswax 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 Triethanolamine 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Propylene glycol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carboxyl Vinyl Polymer 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 antiseptic a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Purified water Balance Balance Balance Balance Balance Balance Balance Balance system 100 100 100 100 100 100 100 100

Experimental Example 3 Skin Moisturizing Evaluation

Moisturizing effect in the stratum corneum was measured using the cosmetics prepared in Examples and Comparative Examples. 120 women of 30 to 40 years old were applied to the facial cosmetics prepared in Examples 1 to 6 and Comparative Examples 1 to 2 twice a day and then used for 1 month. The rate of increase of skin moisturization after 4 weeks was measured using a moisture measuring instrument (corneometer CM825, courage Khazaka electronic GmbH, Germany) at constant temperature and humidity conditions (25 ℃, humidity 45%) before the start of application. The results are shown in Table 5 below, and the results are expressed as average values.

Cosmetics 4 weeks (%) Example 1 63.6 Example 2 18.5 Example 3 19.7 Example 4 18.7 Example 5 20.0 Example 6 17.9 Comparative Example 1 10.6 Comparative Example 2 1.5

As can be seen from the results of Table 5, Examples 1 to 6 in which the osmolite was stabilized with nanoliposomes were effectively delivered into the epidermal layer, thereby increasing the moisturizing power, and as shown in the results of Example 1, the osmo When the mixture was used rather than used alone, it was confirmed that the moisturizing improvement effect was better.

Experimental Example 4 Skin Moisturizing Evaluation

Moisturizing effect in the dermal layer was measured using the cosmetics prepared in Examples and Comparative Examples. 120 women 20 to 30 years of age were applied to each of the cosmetics prepared in Examples 1 to 6 and Comparative Examples 1 to 2 twice a day and then used for 6 weeks. Before application, moisture content was measured using a portable near-infrared spectrometer (NearIRSTA HN2200, SpectronTech, Korea) at a temperature of 1120 ~ 1730nm at constant temperature and humidity conditions (25 ℃, 45% humidity) (J Pharm Soc Korea , 47, 148-153, 2003). The rate of skin moisturization was measured after 2 and 6 weeks. The results are shown in Table 6 below, and the results are expressed as average values.

Cosmetics 2 weeks (%) 6 weeks (%) Example 1 14.8 26.4 Example 2 8.8 14.7 Example 3 8.9 15.5 Example 4 9.3 16.6 Example 5 9.0 16.1 Example 6 8.9 15.9 Comparative Example 1 0.3 0.7 Comparative Example 2 0.0 0.1

As can be seen from the results of the above table, in Examples (1-6) in which osmolite was stabilized with nanoliposomes and Comparative Example 1, which was not stabilized with nanoliposomes, the case of stabilization with nanoliposomes to the deep part of the skin It was shown that the moisturizing power was improved, and in particular, as can be seen from the results of Example 1, it was confirmed that the moisturizing improvement effect was more excellent when the mixture was used than the use of osmolite alone.

Hereinafter, as an example of the cosmetic formulation of the present invention, the softening lotion, lotion, essence, massage cream, shampoo and body cleanser containing the active ingredient of the present invention are exemplified, but the formulation of the cosmetic of the present invention is not necessarily limited thereto. .

Formulation Example 1 Flexible Cosmetics

A flexible cosmetic product containing Preparation Example 1 was prepared according to a conventional method.

Raw material name Content (% by weight) Preparation Example 1 10.0 1,3-butylene glycol 5.2 Oleyl alcohol 1.5 ethanol 3.2 Polysorbate 20 3.2 Benzophenone-9 2.0 Carboxyl Vinyl Polymer 1.0 glycerin 3.5 incense a very small amount antiseptic a very small amount Purified water Balance system 100

[Formulation Example 2] Lotion

Lotions containing Preparation Example 1 were prepared according to a conventional method.

Raw material name Content (% by weight) Preparation Example 1 10.0 Cetostearyl alcohol 1.0 Glyceryl Monostearate 0.8 Sorbitan monostearate 0.3 Porofilparaben 0.1 Polysorbate 60 1.0 Mineral oil 5.0 Pyromethicone 3.0 Dimethicone 0.5 Allantoin 0.1 glycerin 5.0 Alcohol 2 Propylene glycol 3.0 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 3 Essence

An essence containing Preparation Example 1 was prepared according to a conventional method.

Raw material name Content (% by weight) Preparation Example 1 10.0 1,3-butylene glycol 4.0 glycerin 3.0 Allantoin 0.5 Panthenol 0.1 EDTA-2Na 0.01 ethanol 5.0 Triethanolamine 1.5 Squalane 2.0 Beeswax 2.5 Polysorbate 60 3.5 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.5 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 5 Massage Cream

A massage cream containing Preparation Example 1 was prepared according to a conventional method.

Raw material name Content (% by weight) Preparation Example 1 10.0 glycerin 4.0 Vaseline 3.5 Triethanolamine 0.5 Liquid paraffin 24.0 Squalane 3.0 Beeswax 2.1 Tocopheryl acetate 0.1 Polysorbate 60 2.4 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.3 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 6 Shampoo

Shampoo containing Preparation Example 1 was prepared according to a conventional method.

Raw material name Content (% by weight) Preparation Example 1 10.0 Alkyl ether sulfate (30%) 20.0 Alkylamidobetaine (30%) 5.0 Propylene glycol 3.0 Lauramid 4.0 EDTA-2Na 0.1 Polyquaternium-10 0.05 NaCl 0.1 Citric acid 2.4 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 7 Body Cleanser

A body cleanser containing Preparation Example 1 was prepared according to a conventional method.

Raw material name Content (% by weight) Preparation Example 1 10.0 Alkyl ether saccharide (30%) 30.0 Alkyl ether sulfosuccinate (30%) 20.0 Alkylamidobetaine (30%) 5.0 Propylene glycol 5.0 Betaine 5.0 Lauramiddiei 4.0 Cellulose gum 0.05 Hydrolyzed protein 0.1 Citric acid a very small amount NaCl a very small amount incense a very small amount antiseptic a very small amount Purified water Balance system 100

Claims (4)

Cosmetic composition for moisturizing skin containing nanoliposomes comprising one or two or more components selected from inositol, betaine, taurine, homarin, erythritol. The method of claim 1, wherein one or two or more components selected from inositol, betaine, taurine, homarin, erythritol are contained in an amount of 0.1 wt% to 20.0 wt% based on the total weight of the nanoliposomes. Cosmetic composition for. The cosmetic composition for moisturizing skin according to claim 1, wherein the nanoliposome is contained in an amount of 0.1% by weight to 20.0% by weight based on the total weight of the cosmetic composition. The method of claim 1, wherein the cosmetic composition has a formulation selected from the group consisting of softening lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray and powder Cosmetic composition for skin moisturizing, characterized in that