KR100945010B1 - Cancer detection apparatus and method using thereof - Google Patents

Abstract

The present invention discloses a cancer diagnostic apparatus and method thereof. According to an embodiment of the present invention, an apparatus for diagnosing cancer includes a light source unit for outputting a light source for exciting phosphors included in a tissue to diagnose cancer, an integrating sphere for collecting signals outputted from the tissue for the light source, and an integrating sphere And a spectrometer for spectroscopically spectroscopy the signals collected by the wavelength, and a management unit for displaying and managing data for each wavelength spectroscopically analyzed by the spectroscope so as to diagnose cancer of the tissue.

Cancer diagnosis, integrating sphere, oral cancer, NADH, collagen

Description

Cancer diagnosis apparatus and its method {CANCER DETECTION APPARATUS AND METHOD USING THEREOF}

The present invention relates to a cancer diagnosis, and in detail, irradiates a light source to a tissue to diagnose cancer, collects a signal for the light source output from the tissue using an integrating sphere, and spectroscopy according to wavelengths for each wavelength of the tissue. The present invention relates to a cancer diagnosis apparatus and method for diagnosing cancer of a tissue.

In general, the process of diagnosing cancer is made through a biopsy through a surgical operation, the slide is made and stained, and then diagnosed through a microscope. The cancer diagnosis method through the biopsy has the advantage of being able to diagnose accurately, but has the disadvantage that it takes a lot of time.

Cancer can be diagnosed using X-ray, CT (Computer Tomography), and Magnetic Resonance Imaging (MRI), but it is difficult to accurately diagnose because cancer is visually confirmed through the results. .

In addition, there is an optical cancer diagnosis method for observing a fluorescence portion when observing a photosensitive sensor with filtered blue light while injecting a photosensitive agent such as a tumor-specific photogem. Optical cancer diagnostic methods have a long processing time for injecting a photosensitive agent, and it is difficult to catch a weak signal of a tissue. In addition, injecting the photosensitive agent into the patient may cause discomfort to the patient.

An object of the present invention was devised to solve the above problems, by using an integrating sphere to collect a signal for a light source output from the tissue to be diagnosed cancer, based on the wavelength-specific data obtained by spectroscopic wavelength By diagnosing whether or not, there is provided a cancer diagnosis apparatus and method for reducing the time taken to diagnose cancer.

Another object of the present invention is to provide a cancer diagnostic apparatus and method for precisely diagnosing cancer of a tissue by collecting signals for a light source output from the tissue using an integrating sphere.

Another object of the present invention is to measure the difference between the optical elements included in the normal tissue and the tissue to be diagnosed cancer using the integrating sphere, it is possible to compare precisely with the normal tissue, and to accurately determine whether the cancer in a small area The present invention provides a diagnostic device for cancer and a method thereof.

In order to achieve the above object, a cancer diagnostic apparatus according to an aspect of the present invention is a light source for outputting a light source for exciting the phosphors contained in the tissue to be diagnosed cancer, collecting a signal output from the tissue for the light source An integrating sphere, a spectroscope for spectroscopy of the signals collected by the integrating sphere for each wavelength, and an administration unit for displaying and managing data for each wavelength spectroscopically analyzed by the spectroscope so as to diagnose cancer of the tissue. .

In this case, the cancer diagnosis device may further include a lens for collecting the light source output by the light source unit to the tissue.

In this case, the cancer diagnosis apparatus may further include an optical probe connected to the integrating sphere to output the light source to the tissue, and to output a signal output from the tissue to the integrating sphere.

In this case, the light source unit may output the light source for diagnosing oral cancer, and may output a light source having a wavelength range of 400 to 600 [nm].

In this case, the integrating sphere may collect a signal for the light source passing through the tissue and output the signal to the spectrometer, or collect a signal for the light source reflected by the tissue and output the signal to the spectroscope.

In this case, the management unit may display at least one of the pre-stored data of the wavelength for the normal tissue and the data of the wavelength for the tissue together.

According to an aspect of the present invention, a method for diagnosing cancer includes irradiating a light source to a tissue to diagnose cancer, collecting a signal output from the tissue for the light source using an integrating sphere, and collecting the signal by the integrating sphere. It characterized in that it comprises the step of spectroscopy for each wavelength and the spectroscopic data for the wavelength so as to diagnose the cancer of the tissue.

In this case, in the collecting using the integrating sphere, the signal for the light source output through the tissue may be collected using the integrating sphere.

In this case, in the collecting using the integrating sphere, the signal for the light source reflected by the tissue may be collected using the integrating sphere.

The present invention collects the signal for the light source output from the tissue to diagnose cancer by using the integrating sphere, and by diagnosing the cancer based on the wavelength-specific data obtained by spectroscopic wavelength, thereby reducing the time taken to diagnose cancer It can be effective.

In addition, the present invention by collecting the signal for the light source output from the tissue using the integrating sphere, there is an effect that can accurately diagnose the cancer of the tissue.

In addition, the present invention by using the integrating sphere to measure the difference between the normal tissue and the optical elements included in the tissue to be diagnosed cancer, it is possible to precisely compare with the normal tissue, it is possible to accurately diagnose the cancer in a small area It can be effective.

Other objects and features of the present invention in addition to the above object will be apparent from the description of the embodiments with reference to the accompanying drawings.

Hereinafter, an apparatus and a method for diagnosing cancer according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 5.

Since cancer tissues have more active metabolism of cells than normal tissues, the composition and structure of the cancer tissues are different, and thus the optical properties are different.

Optical cancer diagnostic methods for optically diagnosing such cancer tissues are non-invasive and can be applied in most areas where cancer can occur because the diagnosis can be performed in vitro and in vivo using optical fibers.

Integrating spheres are used to measure the optical characteristics of the light source. The integrating sphere is substantially hollow inside, and the inner circumferential surface is surface-treated to diffuse and reflect the light signal incident to the hollow, Minimize errors to pinpoint differences in optical substrates.

In addition, since the integrating sphere can be miniaturized, it may have excellent advantages when applied in medical equipment and cancer diagnosis systems.

The present invention intends to perform optical cancer diagnosis using such an integrating sphere. The gist of the present invention is to diagnose a cancer of a tissue after collecting a signal for a light source output from the tissue using the integrating sphere.

1 is a block diagram of an apparatus for diagnosing cancer according to an embodiment of the present invention.

Referring to FIG. 1, the cancer diagnosis apparatus includes a light source unit 110, a lens 120, an integrating sphere 130, a spectrometer 140, and a management unit 150.

The light source unit 110 outputs a light source for exciting tissues to be diagnosed with cancer, that is, phosphors included in the diagnosis tissue.

In this case, the light source unit 110 may vary the wavelength of the light source to be output according to the optical characteristics of the phosphors included in the tissue to be diagnosed cancer.

For example, in the case of diagnosing oral cancer, the light source unit 110 may output a light source having a wavelength of 400 to 600 [nm], which is a difference in optical properties from normal oral tissue in diagnosing oral cancer. This is because phosphors having NADH (Nicotinamide Adenine Dinucleotide Hydrogen) and collagen (Collagen) have optical properties in the 450 [nm] and 540 [nm] bands, respectively. That is, in the case of oral cancer tissue, the light source unit 110 may diagnose oral cancer by using the characteristics of low optical transmission and high absorption and reflection in the 450 [nm] region (NADH) and the 540 [nm] region (Collagen). It outputs a light source with a wavelength of 400 ~ 600 [nm].

The light source unit 110 preferably includes a means for outputting a light source, and the means for outputting the light source may include a halogen lamp and a Xenon lamp.

The lens 120 collects the light source output by the light source unit 110 to the tissue to diagnose cancer.

That is, the lens 120 effectively transmits the light source output from the light source unit 110 to the cancer diagnosis tissue.

The integrating sphere 130 collects and outputs an optical signal output from the tissue with respect to the light source transmitted to the tissue through the lens 120.

The optical signal collected by the integrating sphere 130 may vary depending on the position of the tissue to diagnose cancer. For example, when the diagnosis tissue is located between the lens 120 and the integrating sphere 130, the integrating sphere 130 The controller 130 collects and outputs a signal for a light source passing through the diagnostic tissue, and when the diagnostic tissue is located behind the integrating sphere 130 as shown in FIG. 1, the integrating sphere 130 is applied to a light source reflected from the diagnostic tissue. Collects and outputs

Here, the integrating sphere 130 reduces the error of the external environment, and collects and outputs the optical signal output from the tissue as much as possible to accurately diagnose the cancer of the tissue.

The spectroscope 140 spectroscopy the optical signal of the diagnostic tissue output from the integrating sphere 130 for each wavelength and outputs data spectroscopically for each wavelength.

In other words, the spectroscope 140 outputs the signals collected from the tissue and collected by the integrating sphere 130 for each wavelength so that the management unit 150 displays the data for each wavelength.

The management unit 150 displays data for each wavelength spectroscopically analyzed by the spectrometer 140 and manages the overall process of the cancer diagnosis apparatus according to the present invention. For example, wavelength-specific data for each cancer tissue to be diagnosed by the cancer diagnostic apparatus and wavelength-specific data for normal tissues are managed, and overall functions of the cancer diagnostic apparatus such as start and end of cancer diagnosis are managed.

At this time, the management unit 150 may display the data for each wavelength of the signal for the light source output from the cancer diagnosis tissue together with at least one of the data for each wavelength of the cancer tissue and the data for each wavelength of the normal tissue.

Here, the wavelength-specific data for normal tissue is preferably measured under the same conditions used to diagnose cancer diagnosis tissue. That is, when the wavelength-specific data for the normal tissue is the reflectance data, the wavelength-specific data for the diagnostic tissue should also be the reflectance data. When the wavelength-specific data for the normal tissue is the transmittance data, the wavelength-specific data for the diagnostic tissue is also the transmittance data. If the wavelength-specific data for normal tissue is absorption data, the wavelength-specific data for diagnostic tissue should also be absorption data.

Diagnosis tissue based on the data displayed through the management unit 150, that is, the wavelength-specific data for the diagnostic tissue to be diagnosed, the wavelength-specific data for the normal tissue or the wavelength-specific data for the diagnostic tissue, and the wavelength-specific data for the cancer tissue. Can determine whether cancer.

In addition, although not shown in Figure 1, the cancer diagnostic device may include an optical probe (probe) to make a diagnosis in the body, the optical probe outputs the light source collected by the lens 120 to the tissue, and from the tissue The signal for the output light source may be received and output to the integrating sphere 130.

For example, the optical probe may be composed of one optical probe at the center and six optical probes at the periphery. The optical probe at the center receives a light source collected through the lens 120 and transmits the light source to the tissue, and the six Light probes receive a signal for a light source output from the diagnostic tissue and output the signal to the integrating sphere 130.

By using a light probe to output a light source to the diagnosis tissue, errors in the absorption rate of the tissue can be minimized, thereby enabling more accurate diagnosis of cancer.

Such an optical probe is preferably mounted on the integrating sphere 130 to output the light source input through the lens 120 to the diagnostic tissue and to output a signal for the light source output from the diagnostic tissue to the integrating sphere 130. . That is, the optical fruit part is mounted on the rear side of the integrating sphere 130 to output the light source received through the lens 120 to the tissue and to receive the signal for the light source output from the tissue to the integrating sphere 130. It is preferable to be.

The cancer diagnosis device according to the present invention will be described below with reference to FIGS. 2 to 4.

2 to 4 are exemplary diagrams for oral cancer diagnosis, which will be described based on data on oral cancer.

Figure 2 is an exemplary view showing the wavelength-specific data on the reflectance of oral cancer tissue and normal oral tissue.

3 is an exemplary view showing wavelength-specific data on the transmittance of oral cancer tissue and normal oral tissue.

Figure 4 is an exemplary view showing the wavelength-specific data on the absorption rate of oral cancer tissue and normal oral tissue.

As can be seen in Figures 2 to 4, cancer tissue can be seen that the high reflectance, low transmittance and high absorption compared to normal tissue.

NADH, which promotes cell growth, which is a phosphor contained in oral tissue, and collagen, which produces blood vessels necessary for cancer metastasis, is a factor directly involved in oral cancer, and it is 450 [nm] and 540 [nm, which are wavelength regions of NADH and collagen. Normal and cancerous tissue are distinguished based on reflectance, transmittance and absorption data.

That is, in the case of oral cancer diagnosis, the present invention diagnoses cancer of oral tissue based on reflectance, transmittance, and absorption rate of NADH and collagen.

For example, as shown in FIG. 2, when the reflectance of NADH and collagen on oral tissue to be diagnosed is higher than a predetermined reflectance of NADH and collagen on pre-stored normal tissue, cancer tissue may be determined. Of course, if the reflectivity of NADH and collagen to the diagnostic tissue is close to the reflectance of NADH and collagen to the oral cancer tissue, it may be determined to be cancer tissue, and if it is lower than a certain level, it may be determined to be normal tissue.

As another example, as shown in FIG. 3, when the permeability of NADH and collagen to oral tissue to be diagnosed is lower than a predetermined permeability of the NADH and collagen to normal tissue, cancer tissue may be determined.

As another example, as shown in FIG. 4, when the absorption rate of NADH and collagen to oral tissue to be diagnosed is higher than the absorption rate of NADH and collagen to normal tissue, it may be determined as cancer tissue.

As can be seen in Figures 2 to 4, oral cancer in the diagnosis of oral tissue, whether oral cancer through the comparison between the data on the NADH and collagen of the oral tissue and the normal tissue NADH and collagen to determine whether oral cancer The extent of comparison between data on diagnostic tissue and data on normal tissue for diagnosing cancer may vary.

5 is an operation flowchart of a cancer diagnosis method according to an embodiment of the present invention.

Referring to FIG. 5, in the cancer diagnosis method, a light source is generated and the generated light source is irradiated to a diagnosis tissue to diagnose cancer (S510).

In this case, the wavelength region of the light source may vary depending on the wavelength region of the phosphors included in the tissue to be diagnosed. For example, in the case of oral cancer diagnosis, the wavelength region of the light source preferably has a wavelength region which may include NADH and collagen, which are phosphors included in oral tissue, for example, a wavelength region of 400 to 600 [nm].

When the light source is irradiated to the diagnostic tissue, an optical signal for the light source is output from the diagnostic tissue, the signal for the light source output from the diagnostic tissue is collected using an integrating sphere, and then spectroscopically spectroscopically by using a spectroscope (S520 and S530). .

In this case, the signal for the light source output from the diagnostic tissue may be a signal for the light source passing through the diagnostic tissue or a signal for the light source reflected by the diagnostic tissue.

In order to diagnose cancer of the diagnosis tissue, the spectroscopic data for the light source is displayed (S540).

Here, the wavelength-specific data of the diagnostic tissue may be displayed with at least one of the wavelength-specific data of the normal tissue and the wavelength-specific data of the cancer tissue, so that it may be easy to determine whether cancer of the diagnostic tissue occurs.

Of course, the wavelength-specific data of the normal tissue and the wavelength-specific data of the cancer tissue is preferably measured and stored under the same conditions.

Apparatus and method for diagnosing cancer according to the present invention can be modified and applied in various forms within the scope of the technical idea of the present invention and are not limited to the above embodiments. In addition, the embodiments and drawings are merely for the purpose of describing the contents of the invention in detail, not intended to limit the scope of the technical idea of the invention, the present invention described above is common knowledge in the technical field to which the present invention belongs As those skilled in the art can have various substitutions, modifications, and changes without departing from the spirit of the present invention, it is not limited to the embodiments and the accompanying drawings. And should be judged to include equality.

1 is a block diagram of an apparatus for diagnosing cancer according to an embodiment of the present invention.

Figure 2 is an exemplary view showing the wavelength-specific data on the reflectance of oral cancer tissue and normal oral tissue.

3 is an exemplary view showing wavelength-specific data on the transmittance of oral cancer tissue and normal oral tissue.

Figure 4 is an exemplary view showing the wavelength-specific data on the absorption rate of oral cancer tissue and normal oral tissue.

5 is an operation flowchart of a cancer diagnosis method according to an embodiment of the present invention.

<Description of Symbols for Main Parts of Drawings>

110: light source

120: lens

130: integrating sphere

140: spectrometer

150: management

Claims (12)

A light source unit for outputting a light source; A lens collecting the light source output by the light source unit; When a light source collected by the lens is output to the oral tissue to excite phosphors including NADH (Nicotinamide Adenine Dinucleotide Hydrogen) and collagen of the oral tissue to be diagnosed with cancer, the signal output from the oral tissue is collected. Integrating Sphere; A spectroscope for spectroscopically analyzing the signals collected by the integrating sphere; And A management unit for displaying and managing the wavelength-specific reflectance, transmittance or absorption data for the oral tissue based on the wavelength-specific reflectance, transmittance or absorbance data for the normal tissue and the signal spectroscopically outputted, In order to diffuse and reflect an optical signal incident to the hollow, oral cancer diagnosis, using the integrating sphere whose inner circumferential surface is processed, collects a signal passing through the oral tissue or a signal reflected from the oral tissue and outputs the signal to the spectroscope. Device. delete The method of claim 1, The oral cancer diagnosis device An optical probe connected to the integrating sphere and outputting a light source collected from the lens to the oral tissue and outputting a signal output from the oral tissue to the integrating sphere Oral cancer diagnostic device further comprising a. delete The method of claim 1, The light source unit An oral cancer diagnostic apparatus for outputting a light source having a wavelength range of 400 [nm] to 600 [nm]. delete delete delete delete A first step of collecting the light source output by the light source unit using a lens and outputting the light to oral tissue to diagnose cancer; A second step in which fluorescent materials including nicotinamide adenine dinucleotide hydrogen (NADH) and collagen of the oral tissue are excited by a light source collected from the lens to collect signals output from the oral tissue and spectroscopically for each wavelength using a spectrometer; And A third step of displaying wavelength-specific reflectance, transmittance or absorption data for the oral tissue based on the wavelength-specific reflectance, transmittance or absorption data for normal tissue and the signal spectroscopically outputted, In the second step, the signal passing through the oral tissue or the signal reflected from the oral tissue is collected and output to the spectroscope using an integrating sphere whose inner peripheral surface is surface-treated to diffuse and reflect the light incident to the hollow. Method of operating oral cancer diagnostic device. delete delete

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