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JPS6413083A - Streptonigrin derivative and medicinal composition - Google Patents

Streptonigrin derivative and medicinal composition

Info

Publication number
JPS6413083A
JPS6413083A JP16955187A JP16955187A JPS6413083A JP S6413083 A JPS6413083 A JP S6413083A JP 16955187 A JP16955187 A JP 16955187A JP 16955187 A JP16955187 A JP 16955187A JP S6413083 A JPS6413083 A JP S6413083A
Authority
JP
Japan
Prior art keywords
formula
compound
lower alkyl
added
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16955187A
Other languages
Japanese (ja)
Inventor
Akishiro Nakamura
Yoshio Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP16955187A priority Critical patent/JPS6413083A/en
Publication of JPS6413083A publication Critical patent/JPS6413083A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound (salt) expressed by formula I [R represents formula II (R' represents lower alkyl, phenylalkyl, etc.), formula III (R<2> and R<3> represent lower alkyl; m is an integer of 0, 1 or 2), formula OR<4> (R<4> represents >=C2 lower alkyl), etc.]. USE:An antitumor agent or reverse transcriptase inhibitor. PREPARATION:For example, a streptorignin and (phenylphosphoryl) bis (1,3- thiazolidin-2-thione) are dispersed in acetonitrile, etc., and triethylamine, etc., are added thereto. Then reaction is carried out while stirring under heating with refluxing in a nitrogen gas stream. Then L-alanine ethyl ester hydrochloride is added thereto. After continuing refluxing, the solvent is distilled under reduced pressure to provide an ester compound. Further this compound is hydrolyzed by heating in an aqueous solution of potassium carbonate to afford the compound expressed by formula I.
JP16955187A 1987-07-07 1987-07-07 Streptonigrin derivative and medicinal composition Pending JPS6413083A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16955187A JPS6413083A (en) 1987-07-07 1987-07-07 Streptonigrin derivative and medicinal composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16955187A JPS6413083A (en) 1987-07-07 1987-07-07 Streptonigrin derivative and medicinal composition

Publications (1)

Publication Number Publication Date
JPS6413083A true JPS6413083A (en) 1989-01-17

Family

ID=15888570

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16955187A Pending JPS6413083A (en) 1987-07-07 1987-07-07 Streptonigrin derivative and medicinal composition

Country Status (1)

Country Link
JP (1) JPS6413083A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320955A (en) * 1991-05-24 1994-06-14 E. R. Squibb & Sons, Inc. 10'desmethoxystreptonigrin production by Streptomyces albus
US5525611A (en) * 1993-06-04 1996-06-11 Behforouz; Mohammad Lavendamycin analogs and methods of making and using them
US5712289A (en) * 1993-06-04 1998-01-27 Ball State University Quinoline-5,8-diones and methods of using them
JP2010500332A (en) * 2006-08-11 2010-01-07 サノフイ−アベンテイス 5,6-bisaryl-2-pyridine-carboxamide derivatives, their preparation and use in their treatment as urotensin II receptor antagonists
JP2012502986A (en) * 2008-09-18 2012-02-02 エヴォテック アーゲー Modulator of P2X3 receptor activity
US8946439B2 (en) 2008-02-29 2015-02-03 Evotec Ag Amide compounds, compositions and uses thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320955A (en) * 1991-05-24 1994-06-14 E. R. Squibb & Sons, Inc. 10'desmethoxystreptonigrin production by Streptomyces albus
US5525611A (en) * 1993-06-04 1996-06-11 Behforouz; Mohammad Lavendamycin analogs and methods of making and using them
US5646150A (en) * 1993-06-04 1997-07-08 Ball State University Methods of using lavendamycin analogs
US5712289A (en) * 1993-06-04 1998-01-27 Ball State University Quinoline-5,8-diones and methods of using them
JP2010500332A (en) * 2006-08-11 2010-01-07 サノフイ−アベンテイス 5,6-bisaryl-2-pyridine-carboxamide derivatives, their preparation and use in their treatment as urotensin II receptor antagonists
US8946439B2 (en) 2008-02-29 2015-02-03 Evotec Ag Amide compounds, compositions and uses thereof
JP2012502986A (en) * 2008-09-18 2012-02-02 エヴォテック アーゲー Modulator of P2X3 receptor activity
US9133122B2 (en) 2008-09-18 2015-09-15 Evotec Ag Amide compounds, compositions and uses thereof

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