[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

JPS53135997A - Haloarylmalonamide oxacephalosporin - Google Patents

Haloarylmalonamide oxacephalosporin

Info

Publication number
JPS53135997A
JPS53135997A JP4963077A JP4963077A JPS53135997A JP S53135997 A JPS53135997 A JP S53135997A JP 4963077 A JP4963077 A JP 4963077A JP 4963077 A JP4963077 A JP 4963077A JP S53135997 A JPS53135997 A JP S53135997A
Authority
JP
Japan
Prior art keywords
haloarylmalonamide
oxacephalosporin
hal
carboxy
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4963077A
Other languages
Japanese (ja)
Other versions
JPS609717B2 (en
Inventor
Yoshio Hamashima
Masayuki Narisada
Sadao Hayashi
Wataru Nagata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP52049630A priority Critical patent/JPS609717B2/en
Priority to CA300,788A priority patent/CA1100962A/en
Priority to ZA00782106A priority patent/ZA782106B/en
Priority to PH21016A priority patent/PH16851A/en
Priority to GB16128/78A priority patent/GB1574273A/en
Priority to DK182878A priority patent/DK182878A/en
Priority to GR56114A priority patent/GR69966B/el
Priority to US05/900,235 priority patent/US4183928A/en
Priority to NZ187086A priority patent/NZ187086A/en
Priority to SU782608717A priority patent/SU784779A3/en
Priority to ES469206A priority patent/ES469206A1/en
Priority to MX787044U priority patent/MX5952E/en
Priority to HU78SI1625A priority patent/HU178105B/en
Priority to FR7812532A priority patent/FR2388815A1/en
Priority to AU35527/78A priority patent/AU522851B2/en
Priority to FI781313A priority patent/FI63410C/en
Priority to PT67957A priority patent/PT67957B/en
Priority to NO781502A priority patent/NO158506C/en
Priority to AR271935A priority patent/AR227614A1/en
Priority to IL54596A priority patent/IL54596A0/en
Priority to NLAANVRAGE7804628,A priority patent/NL189669C/en
Priority to AT311378A priority patent/AT357674B/en
Priority to YU1035/78A priority patent/YU42477B/en
Priority to DD78205105A priority patent/DD135908A5/en
Priority to PL1978206451A priority patent/PL110680B1/en
Priority to DE2818985A priority patent/DE2818985C2/en
Priority to BE187290A priority patent/BE866582A/en
Priority to CH470478A priority patent/CH640535A5/en
Priority to CS782774A priority patent/CS199726B2/en
Priority to IE844/78A priority patent/IE46627B1/en
Priority to IT67986/78A priority patent/IT1111469B/en
Priority to BG039585A priority patent/BG34337A3/en
Publication of JPS53135997A publication Critical patent/JPS53135997A/en
Publication of JPS609717B2 publication Critical patent/JPS609717B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: A compound (Ar is II, III, IV, etc.; Hal, Hal' are halogen; R is OH, protected OH; COA, COB are carboxy, protected carboxy); e.g. 7β-[α-(4-hydroxy2-fluorophenyl)-α-carboxyacetamido]-7α-methoxy-3-(1-methyltetrazol-5-yl) thiomethyl-1-oxadethia-3-cephem-4-carboxylic acid.
COPYRIGHT: (C)1978,JPO&Japio
JP52049630A 1977-04-28 1977-04-28 Haloarylmalonamide oxacephalosporin Expired JPS609717B2 (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
JP52049630A JPS609717B2 (en) 1977-04-28 1977-04-28 Haloarylmalonamide oxacephalosporin
CA300,788A CA1100962A (en) 1977-04-28 1978-04-10 Haloarylmalonamidooxacephalosporins
ZA00782106A ZA782106B (en) 1977-04-28 1978-04-12 Haloalylmalonamidooxacephalosporins
PH21016A PH16851A (en) 1977-04-28 1978-04-17 Haloarylmalonamidooxacephalosporins
GB16128/78A GB1574273A (en) 1977-04-28 1978-04-24 Haloarylmalonamidooxacephalosporins
DK182878A DK182878A (en) 1977-04-28 1978-04-26 HALOARYLMALONAMIDOOXACEPHALOSPORINS AND METHODS FOR THE PREPARATION
GR56114A GR69966B (en) 1977-04-28 1978-04-26
US05/900,235 US4183928A (en) 1977-04-28 1978-04-26 Haloarylmalonamidooxacephalosporins
NZ187086A NZ187086A (en) 1977-04-28 1978-04-26 7-(halophenylmalonamido)-7a-methoxy-3-(optionally alkylated tetrazol-5-yl or 1,3,4-thiadiazol-2-yl)-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
SU782608717A SU784779A3 (en) 1977-04-28 1978-04-26 Method of preparing 7-beta-halogenarylmalonamido-7-alpha-methoxy-heterocyclylthiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid derivatives or their salts with organic or inorganic bases
ES469206A ES469206A1 (en) 1977-04-28 1978-04-27 Haloarylmalonamidooxacephalosporins
MX787044U MX5952E (en) 1977-04-28 1978-04-27 PROCEDURE FOR THE PREPARATION OF ACIDS 7BETA HALOARILMALONAMIDO-7ALFA-METOXI-3-TIOMETIL HETEROAROMATICO-1-DETIA-1-OXA-3-CEFEM-4-CARBOXILICOS
HU78SI1625A HU178105B (en) 1977-04-28 1978-04-27 Process for preparing 7beta-/halo-aryl /-malonamido/- 7alpha-methoxy-3-/ alkyl-tetrazol-5-yl- or -1,3,4-thiadiazol-2-yl /-thiomethyl/- 1-dethia-1-oxa-3-cephem-4-carboxylic acid derivatives
FR7812532A FR2388815A1 (en) 1977-04-28 1978-04-27 PROCESS FOR THE PREPARATION OF HALOARYLMALONAMIDOOXACEPHALOSPORINS, NEW PRODUCTS THUS OBTAINED AND THEIR USE FOR THE TREATMENT OF DISEASES DUE TO BACTERIA
AU35527/78A AU522851B2 (en) 1977-04-28 1978-04-27 Haloarylhalonamidooxacephalosporins
FI781313A FI63410C (en) 1977-04-28 1978-04-27 EXAMINATION OF ANTIBACTERIAL 7BETA-HALOARYLMALONAMIDO-7ALFA-METHOXY-3-HETEROCYCLISK THIOMETHYL-1-DETIA-1-OXA-3-CEFEM-4-CARBOXYL SYRICATE
PT67957A PT67957B (en) 1977-04-28 1978-04-27 Process for preparing haloarylmalonamidooxacephalosporins
NO781502A NO158506C (en) 1977-04-28 1978-04-27 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICAL ACTIVE 7BETA-HALOARYLMALON-AMIDO-7ALFA-METOXY-3- (1-METHYLTETRAZOL-5-YL) THIOMETHYL-1-DETIA-1-OKSA-3-CEFEMY-4-CEFEMY-5-CEFEMY-5-CEFEMY-5-CEFEMY-5-CEFEMY-5
AR271935A AR227614A1 (en) 1977-04-28 1978-04-27 PROCEDURE FOR THE OBTAINING OF 7BETA-HALOARILMALONAMIDO-7ALPHA-METOXI-3-THOMETHYL HETEROCICLICO-1-DETIA-1-OXO-3-CEFEM-4-CARBOXILICOS
IL54596A IL54596A0 (en) 1977-04-28 1978-04-27 Haloraylmalonamidooxacephalosporins and processes for the preparation thereof
NLAANVRAGE7804628,A NL189669C (en) 1977-04-28 1978-04-28 METHOD FOR PREPARING A MEDICINAL PRODUCT WITH ANTIBACTERIAL ACTION AND METHOD FOR PREPARING MEDICINAL OXADETHIACEPHALOSPORINE DERIVATIVES
AT311378A AT357674B (en) 1977-04-28 1978-04-28 METHOD FOR PRODUCING NEW HALOGEN ARYLMALONAMIDOOXACEPHALOSPORINES
YU1035/78A YU42477B (en) 1977-04-28 1978-04-28 Process for obtaining haloarylmalone amido-1-dethio-1-oxa-cephalosporins
DD78205105A DD135908A5 (en) 1977-04-28 1978-04-28 PROCESS FOR PREPARING HALOGENARYLMALONAMIDEOOXACEPHALOSPORINES
PL1978206451A PL110680B1 (en) 1977-04-28 1978-04-28 Method of producing new derivatives of 7-beta-halogeno-arylomalonamido-7-alpha-metoxy-3-heterocyclothiomethylo-1-dethia-1-oxa-3-cephamocarboxylic-4-acid
DE2818985A DE2818985C2 (en) 1977-04-28 1978-04-28 Halogenarylmalonamidooxacephalosporins and their use in combating bacterial infections
BE187290A BE866582A (en) 1977-04-28 1978-04-28 HALOGENOARYLMALONAMIDOOXACEPHALOSPORINS
CH470478A CH640535A5 (en) 1977-04-28 1978-04-28 HALOGEN OR TRIFLUORMETHYLARYLMALONAMIDO-1-DETHIA-1-OXACEPHALOSPORINE AND METHOD FOR THE PRODUCTION THEREOF.
CS782774A CS199726B2 (en) 1977-04-28 1978-04-28 Method of producing 7 beta-halogenaryl-malonamido-7-alpha-methoxy-3-heterocyclylthiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid and derivatives of the same
IE844/78A IE46627B1 (en) 1977-04-28 1978-04-28 Haloarylmalonamidooxacephalosporins
IT67986/78A IT1111469B (en) 1977-04-28 1978-04-28 CEPHALOSPORINE WITH ANTIBACTERIAL ACTION PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BG039585A BG34337A3 (en) 1977-04-28 1978-04-28 Method for obtaining haloarylmalonamido- 1- dethia- 1- oxacephalosporines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52049630A JPS609717B2 (en) 1977-04-28 1977-04-28 Haloarylmalonamide oxacephalosporin

Publications (2)

Publication Number Publication Date
JPS53135997A true JPS53135997A (en) 1978-11-28
JPS609717B2 JPS609717B2 (en) 1985-03-12

Family

ID=12836531

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52049630A Expired JPS609717B2 (en) 1977-04-28 1977-04-28 Haloarylmalonamide oxacephalosporin

Country Status (3)

Country Link
JP (1) JPS609717B2 (en)
BE (1) BE866582A (en)
ZA (1) ZA782106B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5946287A (en) * 1982-07-23 1984-03-15 Meiji Seika Kaisha Ltd Novel 1-oxa-1-dethia-cephalosporin derivative

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2529021Y2 (en) * 1988-06-02 1997-03-12 カヤバ工業株式会社 Active suspension

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5946287A (en) * 1982-07-23 1984-03-15 Meiji Seika Kaisha Ltd Novel 1-oxa-1-dethia-cephalosporin derivative
JPH0352472B2 (en) * 1982-07-23 1991-08-12 Meiji Seika Kk

Also Published As

Publication number Publication date
JPS609717B2 (en) 1985-03-12
BE866582A (en) 1978-08-14
ZA782106B (en) 1979-03-28

Similar Documents

Publication Publication Date Title
JPS5430197A (en) Novel antibiotic compound
JPS5419990A (en) Dihydrotriazinylthioxacephalosporin
JPS53135997A (en) Haloarylmalonamide oxacephalosporin
JPS53111096A (en) 1-azaxanthone-3-carboxylic acid derivative and its preparation
ES8205219A1 (en) Hydrouracil compounds.
JPS5359744A (en) Stablized halogen-containing resin composition
JPS53101391A (en) 1-oxadithiacephem compounds
JPS532404A (en) Elimination of thiol protectors
JPS5334921A (en) Herbicide
JPS5283732A (en) Haloazetidinone compounds
JPS5414952A (en) 1-halogenocarbonyltricyclo(4,3,1,12,5)undecane
JPS53108974A (en) 7-arginylamino-4-methylcoumarin
JPS5392774A (en) 5,6,7,3',4',5'-hexahydrooxyflavone
JPS53127466A (en) Thiocarbamate type heterocyclic compounds and its preparation
JPS549273A (en) 7-arginylamono-4-methylcoumarin
JPS5432470A (en) Triazole compound and herbicide containing the same
JPS545976A (en) 7-glycylprolylamino-4-methylcoumalin
JPS5438345A (en) Vinyl chloride resin compostion
JPS5346955A (en) Polyoxypregnane type compound
JPS52118461A (en) Thiophene-silylenole-ether
JPS5328186A (en) Preparation of novel s-triazine compound
JPS5422390A (en) Alpha-acylamino-p-hydroxybenzylpenicillin
JPS5422391A (en) Preparation of novel 7alpha-methoxycephalosporins
JPS53103415A (en) Preparation of trihalocarboxylic acid ester
JPS5439088A (en) Novel antibacterial agents