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JPS5253851A - Novel sterile agent - Google Patents

Novel sterile agent

Info

Publication number
JPS5253851A
JPS5253851A JP51121787A JP12178776A JPS5253851A JP S5253851 A JPS5253851 A JP S5253851A JP 51121787 A JP51121787 A JP 51121787A JP 12178776 A JP12178776 A JP 12178776A JP S5253851 A JPS5253851 A JP S5253851A
Authority
JP
Japan
Prior art keywords
sterile agent
novel sterile
novel
agent
sterile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP51121787A
Other languages
English (en)
Other versions
JPS61343B2 (ja
Inventor
Deibitsudo Jiyoonzu Shii
Suarezu Tourio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5253851A publication Critical patent/JPS5253851A/ja
Publication of JPS61343B2 publication Critical patent/JPS61343B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP51121787A 1975-10-28 1976-10-08 Novel sterile agent Granted JPS5253851A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62601075A 1975-10-28 1975-10-28

Publications (2)

Publication Number Publication Date
JPS5253851A true JPS5253851A (en) 1977-04-30
JPS61343B2 JPS61343B2 (ja) 1986-01-08

Family

ID=24508581

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51121787A Granted JPS5253851A (en) 1975-10-28 1976-10-08 Novel sterile agent

Country Status (31)

Country Link
US (1) US4133814A (ja)
JP (1) JPS5253851A (ja)
AR (3) AR222959A1 (ja)
AT (1) AT357520B (ja)
AU (1) AU505360B2 (ja)
BE (1) BE847719A (ja)
BG (2) BG28065A4 (ja)
CA (1) CA1090795A (ja)
CH (3) CH635336A5 (ja)
CS (2) CS205047B2 (ja)
DD (1) DD127461A5 (ja)
DE (1) DE2647907C2 (ja)
DK (1) DK152045C (ja)
ES (2) ES452695A1 (ja)
FR (1) FR2329271A1 (ja)
GB (1) GB1570610A (ja)
GR (1) GR61776B (ja)
HU (1) HU179012B (ja)
IE (1) IE44392B1 (ja)
IL (1) IL50773A (ja)
MX (1) MX4584E (ja)
NL (1) NL7611975A (ja)
NZ (1) NZ182429A (ja)
PH (1) PH14219A (ja)
PL (2) PL107979B1 (ja)
PT (1) PT65755B (ja)
RO (1) RO70769A (ja)
SE (1) SE426945B (ja)
SU (2) SU701539A3 (ja)
YU (1) YU262076A (ja)
ZA (1) ZA766440B (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010113A1 (en) * 1991-11-15 1993-05-27 Teikoku Hormone Mfg. Co., Ltd. Novel benzothiophene derivative
JPH07196495A (ja) * 1993-12-14 1995-08-01 Eli Lilly & Co ベンゾチオフェン化合物と水溶性シクロデキストリンとの包接複合体水溶液、およびそれらの医薬品製剤、並びにそれらの用途
US6951848B2 (en) * 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
JP2012012400A (ja) * 2003-12-24 2012-01-19 Clariant Specialty Fine Chemicals (France) Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法
EP3789027A1 (en) 2015-01-13 2021-03-10 Kyoto University Bosutinib, sunitinib, tivozanib, imatinib, nilotinib, rebastinib or bafetinib for preventing and/or treating amyotrophic lateral sclerosis

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IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
IL65378A (en) 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5196435A (en) * 1991-11-21 1993-03-23 Eli Lilly And Company Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma
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US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
GB9309324D0 (en) * 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
IL109990A (en) * 1993-06-21 1999-06-20 Lilly Co Eli Materials and methods for screening anti-osteoporosis agents
ES2105525T3 (es) * 1993-06-24 1997-10-16 Lilly Co Eli 2-fenil-3-aroilbenzotiofenos antiestrogenicos como agentes hipoglicemicos.
TW303299B (ja) * 1993-07-22 1997-04-21 Lilly Co Eli
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5391557A (en) * 1993-10-15 1995-02-21 Eli Lilly And Company Methods for the treatment of peri-menopausal syndrome
US5418252A (en) * 1993-10-15 1995-05-23 Eli Lilly And Company Method for inhibiting cartilage degradation
ZA948025B (en) * 1993-10-15 1996-04-15 Lilly Co Eli Methods for treating resistant neoplasms
US5441964A (en) * 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
US5457113A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
US5461065A (en) * 1993-10-15 1995-10-24 Eli Lilly And Company Methods for inhibiting endometriosis
US5457116A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods of inhibiting uterine fibrosis
CN1058390C (zh) * 1993-10-15 2000-11-15 伊莱利利公司 苯并噻吩类化合物的用途
US5480904A (en) * 1993-10-28 1996-01-02 Eli Lilly And Company Methods for inhibiting uterine fibrosis
US6489355B2 (en) * 1993-12-01 2002-12-03 Eli Lilly And Company Methods of inhibiting the effects of amyloidogenic proteins
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US6417198B1 (en) * 1993-12-21 2002-07-09 Eli Lilly And Company Methods of inhibiting CNS problems in post-menopausal women
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US5389670A (en) * 1993-12-21 1995-02-14 Eli Lilly Company Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder
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Publication number Priority date Publication date Assignee Title
WO1993010113A1 (en) * 1991-11-15 1993-05-27 Teikoku Hormone Mfg. Co., Ltd. Novel benzothiophene derivative
US5472962A (en) * 1991-11-15 1995-12-05 Teikoku Hormone Mfg. Co., Ltd. Benzothiophene derivative
JPH07196495A (ja) * 1993-12-14 1995-08-01 Eli Lilly & Co ベンゾチオフェン化合物と水溶性シクロデキストリンとの包接複合体水溶液、およびそれらの医薬品製剤、並びにそれらの用途
US6951848B2 (en) * 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
JP2012012400A (ja) * 2003-12-24 2012-01-19 Clariant Specialty Fine Chemicals (France) Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法
JP4896735B2 (ja) * 2003-12-24 2012-03-14 クラリアント スペシャルティー ファイン ケミカルズ（フランス） Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法
EP3789027A1 (en) 2015-01-13 2021-03-10 Kyoto University Bosutinib, sunitinib, tivozanib, imatinib, nilotinib, rebastinib or bafetinib for preventing and/or treating amyotrophic lateral sclerosis

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FR2329271B1 (ja) 1979-07-27
BG27553A3 (en) 1979-11-12
ES452695A1 (es) 1977-11-16
IL50773A0 (en) 1976-12-31
JPS61343B2 (ja) 1986-01-08
AU1900576A (en) 1978-05-04
IL50773A (en) 1980-03-31
SU701539A3 (ru) 1979-11-30
SE426945B (sv) 1983-02-21
DE2647907C2 (de) 1985-01-24
NL7611975A (nl) 1977-05-02
HU179012B (en) 1982-08-28
US4133814A (en) 1979-01-09
BG28065A4 (en) 1980-02-25
CS205046B2 (en) 1981-04-30
DE2647907A1 (de) 1977-05-12
AR222796A1 (es) 1981-06-30
PH14219A (en) 1981-04-02
BE847719A (fr) 1977-04-28
MX4584E (es) 1982-06-25
CH634316A5 (de) 1983-01-31
CS205047B2 (en) 1981-04-30
DD127461A5 (ja) 1977-09-28
ATA800876A (de) 1979-12-15
CH635582A5 (de) 1983-04-15
AU505360B2 (en) 1979-11-15
PL107979B1 (pl) 1980-03-31
DK484876A (da) 1977-04-29
ES452694A1 (es) 1977-11-16
CH635336A5 (de) 1983-03-31
YU262076A (en) 1983-01-21
ZA766440B (en) 1978-06-28
CA1090795A (en) 1980-12-02
IE44392B1 (en) 1981-11-18
IE44392L (en) 1977-04-28
PT65755A (en) 1976-11-01
RO70769A (ro) 1982-10-26
PL114190B1 (en) 1981-01-31
DK152045C (da) 1988-06-20
AT357520B (de) 1980-07-10
NZ182429A (en) 1978-11-13
SE7611955L (sv) 1977-04-29
AR215930A1 (es) 1979-11-15
PT65755B (en) 1978-04-27
FR2329271A1 (fr) 1977-05-27
AR222959A1 (es) 1981-07-15
DK152045B (da) 1988-01-25
GB1570610A (en) 1980-07-02
PL193308A1 (pl) 1978-03-28
SU764610A3 (ru) 1980-09-15
GR61776B (en) 1979-01-16

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