JPS5987035A - W/o type emulsion composition stably containing urea - Google Patents

Abstract

PURPOSE:To make it possible to obtain a W/O type emulsion stable even if urea and an inorg. salt being a urea decomposition suppressing agent are added, by using an emlsifier composition consisting of specific polyhydric alcohol esters and branched chain hydrocarbon. CONSTITUTION:A W/O type emulsion comprises five components, that is, 1- 30wt% of an emulsifier composition (A) consisting of at least one polyhydric alcohol esters obtained from glycerine, diglycerine or polyoxythylene adduct thereof and fatty acid and branched chain hydrocarbon, 1-30wt% of urea (B), 0.1-10wt% of an ammonium compound (e.g., ammonium chloride) (C), 5- 50wt% of oily component (D) and water (E) in an amount bringing the whole to 100wt%. In addition, the wt. ratio of polyhydric alcohol esters and branched chain hydrocarbon in the component (A) is adjusted to 1:0.05-1:6 and the fatty acid in the component (A) is selected from 8-22C saturated fatty acid and unsaturated fatty acid (e.g., caprinic acid).

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a WlO type emulsion in which urea is blended with Kito F3JJ, and more specifically to a WlO emulsion that stably contains urea and is useful in the fields of cosmetics and medicinal preparations.

Urea changes the polypeptides of proteins, increasing their solubility, and has dermatological effects such as antibacterial effects, proteolytic denaturation effects, hydration phenomena, i.e., the ability to retain water, and unique properties such as the ability to improve skin absorption. It has important pharmacological effects.

Conventionally, cosmetics and medicated creams containing 5 to 20% by weight of urea in an O/W emulsion are known as examples of all-urea formulations. Skewer≠Skewer; Generally, W10 type emulsion is better than 0/W type emulsion.
Bacteria [lr pair characteristics, moisture vapor dissipation, protective effect,
It has advantages in terms of low temperature stability and composition similar to sebum. It is generally known that the action of physiologically active substances such as urea from W10 emulsions on the skin occurs more slowly than from 0/W emulsions. Therefore, by incorporating all urea into the WlO type emulsion, the humidity level in the stratum corneum can be stabilized for an extremely long period of time.

However, despite the above advantages, w/.

Adding urea to the mold emulsion was difficult due to the following points. Unfortunately, the combination of urea rather than wZo type emulsion further impairs stability.

- Is urea easily hydrolyzed by acid, alkali, heat, etc. in the presence of water or ammonia? As a result, the product value decreases due to the generation of ammonia odor, and the undesirable factors of impairing the skin's ability to neutralize alkali and promoting skin infections are promoted. . In order to completely stably incorporate urea into a water-containing composition, attempts have been made to improve stabilization by adding ammonium salts such as 7° ammonium chloride or ammonium sulfate.

Currently, emulsifiers with low HLB such as lanolin derivatives, nlupitan fatty acid esters, glyceryl fatty acid esters, polyoxyethylene alkyl ethers, and polyoxyethylene sorbitol fatty acid esters are used as emulsifiers for wiom emulsions. However, if these emulsifier compositions alone are combined with urea and an inorganic salt as a urea stabilizer, even if they are stable at room temperature, they will quickly separate under high or low temperature conditions.

Furthermore, in order to improve the stability of the W10 emulsion, efforts have been made to improve the stability by increasing the amount of oil or increasing the viscosity, but as a result, the feeling of use of the emulsion It spoils the product and is more sticky and oily than necessary!・There was a tendency for consumers to dislike this product because it gave all the details.

As described above, the W10 type emulsion containing urea lacked stability and was inferior in quality to O/W emulsions for the same purpose.

The inventors of the present invention have found that the product is stable over a wide temperature range, has no temperature change in hardness and consistency due to forced stability, and has a light feeling of use without excessive stickiness or oiliness. With the aim of providing a urea-containing W10 emulsion that gives It was discovered that a stable wZo type emulsion can be obtained even when an inorganic salt, which is a urea decomposition inhibitor, is added, and the present invention has been completed.

That is, the present invention comprises components (A) an emulsifier m-acid consisting of a polyhydric alcohol ester and a branched hydrocarbon; 1 to 30% by weight; (B) urea; 1 to 30% by weight; (C) an ammonium compound. o, from 1 to 10% by weight, (to) oily component; from 5 to 50% by weight, (g) total 1
W that stably contains urea, which is characterized by being composed of 5 components of 0,000% water by weight.
The present invention relates to a type 10 emulsion composition.

The polyhydric alcohol esters of component (4) used as the emulsifier composition in all the compositions of the present invention are ester compounds obtained from the polyhydric alcohol amount of tallycerin, diglycerin, or their polyoxyethylene adducts and fatty acids. At least one type. The number of moles of polyoxyethylene added to the polyhydric alcohol li in component (a) is 10
Preferably 40 to 40 moles (-1.
At least 1f selected from saturated fatty acids and unsaturated fatty acids! These fatty acids can include, for example, capric acid, lauric acid, oleic acid, -17-ruci, ricinoleic acid, isooctanoic acid, isopalmitic acid and isostearic acid, but especially oleic acid and Instearic acid is preferred. The polyalco-A/esters obtained from these raw materials include glyceryl mono-, no-olate, glyceryl diolate, glyceryl monoisostearate, glyceryl triisostearate, diglyceryl monooleate, diglyceryl monoiso Stearate, diglyceryl==iso2?
) Polyoxyethylene (20 mol) glyceryl triisostearate and diglyceryl dioleate
I can do something.

The other component of the components used as an emulsifier composition in the non-inventive composition is a branched chain hydrocarbon having a melting point of 60 to 110°C, but in particular a microcrystalline wax with a melting point of 60 to 110°C is used. Microlistalline wax having a high melting point of 95° C. is preferred.

The blending ratio of component (g) polyhydric alcohol esters and branched chain hydrocarbons is 1,0% of the polyhydric alcohol esters.
The amount of the branched hydrocarbon can be selected as appropriate within the range of 0.05 to 6 parts by weight, preferably 0.1 to 4 parts by weight, based on the weight of the polydisperse. If the mixing ratio of both is outside this range,
Both are unfavorable because they reduce the stability of emulsification.

In the uninvented composition, ammonium compounds represented by the component (Q) include ammonium chloride, ammonium sulfate, ammonium nitrate, ammonium phosphate 1, ammonium borate, ammonium acetate, ammonium siolate, ammonium tartrate, etc. Among these, ammonium chloride is particularly preferred.

In addition to microcrystalline wax, the oily components indicated by component (to) include mineral oil, petrolactam, paraffin, squalane hydrocarbons, isopropyl myristate, inglovir palmitate, cetyl 2-ethylhexanoate, and hegysyl laurate. Oil-based components include synthetic ester oils such as olive oil, jojoba oil, natural oils such as wheat germ oil and mink oil, natural waxes such as spermaceti wax, wood wax, carnauba wax, and hydrogenated castor oil, and hydrogenated oils.

Of the blending ratio of the composition of the present invention, the blending ratio of the ingredient is 1
If it is less than 36, the W10 type emulsion cannot be stabilized, and if it exceeds 36, it will take on a gel structure, which is not preferable for use. In addition, if the blending ratio of component C) is less than one stroke, no infiltration effect of urea can be expected, and if the ratio is 30% or more, crystals tend to precipitate at low temperatures, which is undesirable. If the blending ratio is less than 0.1%, the urea content is A! It is insufficient to suppress 10
%, it is not preferable because the f/c tends to deteriorate low temperature stability. In addition, an emulsion can be obtained even if the blending ratio of component (■) is less than 5 parts, but if such a product is applied to the skin, the resistance of the remaining oil film to moisture permeation will decrease. , the purpose of skin protection is not achieved and it is not pleasant.Also, when it exceeds 70%, the feeling of oily stickiness becomes stronger when used. is not achieved, which is still not desirable.

Further, although any combination of water and water may be blended, it is preferable to blend 40 or more water in order to provide a good feeling when using, that is, to reduce oily or sticky feeling.

The W10 type emulsion of the present invention includes the emulsifier composition (5), urea (B), ammonium compound (C),
In addition to the oily component (①) and the five essential water components (provided), other surfactants, viscosity, A-adjusting agents, medicinal agents, wetting agents, preservatives, antioxidants, urea stabilizers, etc. may be added as necessary. It can be added as appropriate.

Viscosity modifiers include synthetic polymers such as polyvinyl alcohol, carboxyvinyl polymer, hydroxyethyl cellulose, and methyl cellulose, natural polymers such as hectin and sodium alginate, and medicinal agents include bactericides, anti-inflammatory agents, vitamins, and skin moisturizers. etc., but as a moist tear agent,
Propylene glycol, glycerin, 1,3-butynone f IJ col, sodium pyrrolidone carboxylate,
Preservatives include methyl paraoxybenzoate, ethyl haloxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, sodium benzoate, sorbic acid, potassium sorbate,
Phenoxyethanol etc. 1. Examples of urea stabilizers include ammonium salts, neutral amino acids, alkanolamines, and the like.

The W10fn emulsion of the present invention is prepared using a conventional method.
1 to 30% by weight of the emulsifier composition of ), preferably,
5 to 15 parts 1 and 1 to 30 parts of urea (component CB)
Weight factor preferably 5 to 20 weight factor and ingredients (Q ammonium compound 0.1 to 10 weight factor, preferably 5 to 20 weight factors,
0.1 to 3 weight ratio and component ■) oily component 5 to 5
Preferably, 15 to 30% by weight is blended with appropriate amounts of other surfactants, viscosity modifiers, medicinal agents, wetting agents, repellents, 6' anchorage inhibitors, and urea. Add stabilizers,
It is further manufactured by adjusting the remainder with water from the ingredients.

The urea-containing W10 emulsion thus obtained is mainly used in the cosmetic and medicinal formulation fields for skin and eyebrow care.
It can be applied to products aimed at improving skin and JH retention. Forms suitable for this purpose, such as hand creams, nutritional creams, emulsions, 6 cold creams, vanishing creams,
It can be a cleansing cream, a hair cream and a foundation cream.

In terms of stability, the W10u emulsifier bile composition of the present invention has a high stability due to the presence of multiple alcohol esters in microcrystals, and by mixing in a ratio of 105 to 1:6, side chains The structural characteristics of microcrystalline wax, in which a cyclic 14-structure is present anywhere in the molecule, appear, and W1 has high emulsion stability, which dissolves in the continuous phase of oily wax, and has very little change in consistency.
It is presumed that this is because the type 0 emulsion is completely formed.

The present invention will be explained in detail below with reference to all embodiments.

Examples 1 to 3, Comparative Examples 1 to 3 Using the surfactants shown in Table 2, the components (4
) to (g) were all prepared. To prepare the emulsion, first add ingredients Q\) and ■) in Table 1 to 8
Heat to 0°C, stir to dissolve uniformly, and add 7
Components (B) and (C1, ■) which had been uniformly dissolved at 5°C were added and cooled after emulsification. After the temperature was lowered to 30°C, stirring was completely stopped. 7. Observation of the state of the obtained emulsion. #lIJ determination of emulsion stability was carried out.

The results are shown in Table 2.

From the results in Table 2, it can be seen that the W/'0 type emulsion of the present invention has better emulsion stability than the W10 type emulsion obtained from a known emulsifier with a low HLB. is clear.

Comparative Examples 4 to 11 Emulsion gold was prepared using the same composition and method as in Example 1, except for μ, in which the microcrystalline wax in Example 1 was replaced with the waxes shown in Table 3, and the electrical resistance value and emulsion stability were examined. .

The results are shown in Table 3.

As is clear from the results in Tables 2 and 3, polyhydric alcohol esters and branched chain hydrocarbons were combined to form emulsifiers.

Furthermore, in order to investigate the stability of the viscosity against changes in temperature (i), the viscosity of the cream of Example 1 and the cream of Comparative Example 4 was determined according to the following measuring method.

The results are shown in Table 4.

(Measurement method) Using a rheometer (manufactured by Fudo Kogyo ■), measure the consistency of the cream after keeping it at 25℃ for one week, then keeping it at 50℃ for 3 days, and returning it to 25℃ on Saturdays and Sundays.
A disk with a diameter of 10 m! : The stress was measured when sinking at a speed of 2σ/sec.

Table 4 As is clear from the results in Tables 2, 3, and 4, an emulsifier was prepared by combining a polyhydric alcohol ester and a branched hydrocarbon.

The emulsion composition of the present invention had good emulsion stability and temperature stability of viscosity. On the other hand, with emulsifier component 1 using other waxes and known emulsifiers, it is difficult to obtain a stable W10n emulsion containing urea, ammonium chloride, etc., and when a W/'0 type emulsion is entirely formed, However, the oil or water is separated,
A stable emulsion could not be obtained. On the other hand, when trying to obtain the same level of stability as using the malting agent component of the present invention, the amount of waxes increases, giving the product a consistency that is not suitable for use.

Below, Example 4: Ingredients (A), 100%, and 3 shown in 5th coating were uniformly dissolved at 80° C. 7' = (Bath liquid 1). On the other hand, component (B) was added and dissolved in a pot in which the above components C) and (I) were uniformly dissolved at 75° C. (Solution 2). Next, solution 2 was gradually added to the solution 1 while stirring with an emulsifying machine, emulsified, and then cooled. In addition, component (G)'(z was added and emulsified at 70°C during the cooling process, and stirring was stopped after the temperature was lowered to 30°C.

The W10 type emulsion thus obtained was
:;The texture of V was fine and good, making it ideal for use as a skin cream. This product was extremely stable even when stored in a constant temperature bath at 50°C for over 2 months.

When a sensory test was conducted by 23 panelists, all of them answered that the J& used felt smooth.

Example 5 Table 6 Components in Table 6 Q10), IF) were uniformly dissolved at 75°C (Solution 1). - Ingredients of the Mansaku 5 table (Q, ■, (G)
'(i) After uniformly melting at 5°C, component ω was added and dissolved (@Yu2). While stirring solution 1 with an emulsifier, solution 2' was added and emulsified. After the temperature was lowered to 30°C, stirring was stopped.

The emulsion produced in this way is of the W2O type and is ideal as a protective cream for dry nappies.
It was stable even when stored for more than 2 months. And Panera
In a sensory test conducted by 23 people, 19 people said that it felt rough when using it.

The following margin Example 6゜Table 7 Ingredients (g), (6), (g), (Q shown in Table 7)
It was uniformly dissolved at 5°C (solution 1). -Force component (C), (
After uniformly dissolving El at 75°C, component (B) was further dissolved (solution 2). Next, Solution 2 was added to Solution 1 while stirring with an emulsifying machine to emulsify it, and after the temperature was lowered to 30° C., stirring was stopped.

The appearance of the emulsion U, W2O type emulsion, which was most suitable as an emollient emulsion, was (d) fine and good texture, a, 50°C.
He held the position for more than a month and remained stable for 10 years.

A panel of 23 people (who conducted a sensory test based on τ) found that 20 people answered that it had a 2.1p feel and felt dry.

Claims (1)

[Claims] 1. (2) An emulsifier composition comprising glycerin, diglycerin, or a polyoxyethylene adduct thereof and at least one polyhydric alcohol ester obtained from a fatty acid and a branched hydrocarbon. Urea: 1 to 307% by weight (Q Ammonium compound; 0.1% to 10% by weight (D) Oil component; 5 to 50% by weight) Overall sound x
W contained in the total stability of urea, which is characterized by being composed of 5 components of water with an oz amount.
Type 10 emulsion composition. 2. The composition according to claim 1, wherein the ratio of the polyhydric alcohol ester and the branched chain hydrocarbon as the components is from 1:0.05 to 1:6 by weight. 3. The composition according to claim 1, wherein the fatty acid constituting the polyhydric alcohol ester of component (4) is at least one selected from saturated fatty acids and unsaturated fats having 8 to 22 carbon atoms. . 4. The branched chain hydrocarbon component is a microcrystalline wax with a melting point of 60 to 110°C! i
A composition according to claim 1. 5. The ammonium compound of component (C) is ammonium chloride, Tm9 ammonium, ammonium nitrate,
The composition according to claim 1, which is at least one selected from ammonium phosphate, ammonium borate, ammonium acetate, ammonium oxalate, and ammonium tartrate.