JPS5735556A - Preparation of guanidinomethylcyclohexanecarboxylic acid ester - Google Patents
Preparation of guanidinomethylcyclohexanecarboxylic acid esterInfo
- Publication number
- JPS5735556A JPS5735556A JP10835380A JP10835380A JPS5735556A JP S5735556 A JPS5735556 A JP S5735556A JP 10835380 A JP10835380 A JP 10835380A JP 10835380 A JP10835380 A JP 10835380A JP S5735556 A JPS5735556 A JP S5735556A
- Authority
- JP
- Japan
- Prior art keywords
- trans
- acid
- guanidinomethylcyclohexanecarboxylic
- benzyloxycarbonylphenyl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound having an action of proteolytic enzyme industrially advantageously, by reacting di-O-benzyloxycarbonylphenyl sulfinic acid with trans-4-guanidinomethyl-cyclohexanecarboxylic acid or its salt.
CONSTITUTION: Di-O-benzyloxycarbonylphenyl sulfinic acid obtained by reacting benzyl salicylate with a thionyl halide in the presence of an oxidizer is reacted with trans-4-guanidinomethylcyclohexanecarboxylic acid or its salt in a solvent, e.g., DMF, etc. at room temperature for 10W30hr wit stirring, to give the desired compound easily.
EFFECT: Benzyl salicylate is extremely inexpensive, and can be recovered from the reaction solution easily in high yield. The yield from trans-4-guanidinomethylcyclohexanecarboxylic acid is extremely high.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10835380A JPS5735556A (en) | 1980-08-08 | 1980-08-08 | Preparation of guanidinomethylcyclohexanecarboxylic acid ester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10835380A JPS5735556A (en) | 1980-08-08 | 1980-08-08 | Preparation of guanidinomethylcyclohexanecarboxylic acid ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5735556A true JPS5735556A (en) | 1982-02-26 |
| JPS6351146B2 JPS6351146B2 (en) | 1988-10-13 |
Family
ID=14482555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10835380A Granted JPS5735556A (en) | 1980-08-08 | 1980-08-08 | Preparation of guanidinomethylcyclohexanecarboxylic acid ester |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5735556A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60250595A (en) * | 1984-05-25 | 1985-12-11 | アールディエス株式会社 | Device for firing low voltage incandescent bulb |
| US6284791B1 (en) | 1994-08-30 | 2001-09-04 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
| US6444703B1 (en) | 1995-12-22 | 2002-09-03 | Teikoku Chemical Industries Co., Ltd. | Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections |
-
1980
- 1980-08-08 JP JP10835380A patent/JPS5735556A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60250595A (en) * | 1984-05-25 | 1985-12-11 | アールディエス株式会社 | Device for firing low voltage incandescent bulb |
| US6284791B1 (en) | 1994-08-30 | 2001-09-04 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
| US6831190B1 (en) | 1994-08-30 | 2004-12-14 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
| US6444703B1 (en) | 1995-12-22 | 2002-09-03 | Teikoku Chemical Industries Co., Ltd. | Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6351146B2 (en) | 1988-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5735556A (en) | Preparation of guanidinomethylcyclohexanecarboxylic acid ester | |
| JPS55162763A (en) | Perfluoroalkyl compound and its preparation | |
| JPS5517339A (en) | Preparation of thiourea dioxide | |
| JPS57118535A (en) | Preparation of fluoroalkyl alpha-chloroacrylate | |
| JPS5430128A (en) | Preparation of water impregnated substance of diperisophthalic acid tent-butyl ester | |
| JPS577438A (en) | Production of acid chloride | |
| JPS55127343A (en) | Preparation of oxy-di-phthalic acid or acid anhydride | |
| JPS5212146A (en) | Process for preparation of p- acetylaminobenzene-sufonylchloride | |
| JPS51146415A (en) | Preparation of an ammonium salt of unsaturated acids | |
| JPS5439042A (en) | Preparation of 2-(4-iso butylphenyl)-propionic acid | |
| JPS52125138A (en) | Preparation of aromatice aldehydes | |
| JPS5295653A (en) | Preparation of o-sulfobenzoic acid imide | |
| JPS5576881A (en) | Preparation of high-purity coproporphyrin 3 alkali salt | |
| JPS5543004A (en) | Preparation of alpha-thio-gammadelta-unsaturated carbonyl compound | |
| JPS5535058A (en) | Preparation of n- (1-ethyl-2-pyrrolidinyl)methyl -2- methoxy-5- sulfamoyl-benzamide | |
| JPS5555135A (en) | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid | |
| JPS57145827A (en) | Optical resolution of allethrolone | |
| JPS57149253A (en) | Preparation of nitroacetic esters | |
| JPS56110639A (en) | Preparation of carboxylic acid chloride | |
| JPS5441868A (en) | Production of n-alkylpyrrolyl-2-acetic acid | |
| JPS5289603A (en) | Preparation of perfluorovinyl compounds | |
| JPS5520706A (en) | Preparation of metoclopramide | |
| JPS5422363A (en) | Preparation of thiophene-substituted fatty acid halide | |
| JPS5651436A (en) | Preparation of p-chlorocarbonylbenzoic acid methyl ester | |
| JPS54141723A (en) | Preparation of beta-hydroxyamino acid |