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JPS5728061A - Pyridazinone derivative - Google Patents

Pyridazinone derivative

Info

Publication number
JPS5728061A
JPS5728061A JP10536080A JP10536080A JPS5728061A JP S5728061 A JPS5728061 A JP S5728061A JP 10536080 A JP10536080 A JP 10536080A JP 10536080 A JP10536080 A JP 10536080A JP S5728061 A JPS5728061 A JP S5728061A
Authority
JP
Japan
Prior art keywords
formula
derivative expressed
ulcer
expressed
gastric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10536080A
Other languages
Japanese (ja)
Inventor
Toshihiro Yamada
Yoichi Nobuhara
Hiroshi Shimamura
Zenji Tsukamoto
Masahiko Oki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Original Assignee
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MORISHITA SEIYAKU KK, Morishita Pharmaceuticals Co Ltd filed Critical MORISHITA SEIYAKU KK
Priority to JP10536080A priority Critical patent/JPS5728061A/en
Priority to EP19800304409 priority patent/EP0030835B1/en
Priority to ES498263A priority patent/ES8201553A1/en
Priority to DE8080304409T priority patent/DE3063196D1/en
Priority to AT80304409T priority patent/ATE3288T1/en
Publication of JPS5728061A publication Critical patent/JPS5728061A/en
Pending legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A pyridazinone derivative expressed by formula I (R1, R2 and R3 are H, halogen, lower alkyl or lower alkyloxy; R4 and R5 are H or lower alkyl; X is S or -CH2-; m is an integer 1W3; n is 0 or an integer 1W3).
EXAMPLE: N-Cyano-N'-[ 3-[ 6-( 4-chlorophenyl )-3-oxo-2-pyridazinyl ]propyl ]-N'- methylguanidine.
USE: A medicine, useful as a remedy and a preventing agent aginst peptic ulcers, e.g. gastric hyperacidity, gastric ulcer and duodenal ulcer, and capable of exhibiting the activity of inhibiting the gastric juice secretion and inhibiting the development of a experimental ulcers, e.g. the aspirin, stress or Shay ulcer, with prolonged action, weak toxicity and improved chemical resistance.
PROCESS: An amine derivative expressed by formula II is reacted with dimethyl cyanodithioimidocarbonate to give an isothiourea derivative expressed by formula III, which is then reacted with an amine derivative expressed by formula IV in an inert solvent at room temperature or under heating for several hours to afford the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP10536080A 1979-12-05 1980-07-29 Pyridazinone derivative Pending JPS5728061A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP10536080A JPS5728061A (en) 1980-07-29 1980-07-29 Pyridazinone derivative
EP19800304409 EP0030835B1 (en) 1979-12-05 1980-12-05 Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
ES498263A ES8201553A1 (en) 1979-12-05 1980-12-05 Procedure for the preparation of derivatives of 6-fenil-3 (2H) -piridacinona 2-substitute. (Machine-translation by Google Translate, not legally binding)
DE8080304409T DE3063196D1 (en) 1979-12-05 1980-12-05 Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
AT80304409T ATE3288T1 (en) 1979-12-05 1980-12-05 2-SUBSTITUTED-6-PHENYL-3(2H)-PYRIDAZINONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10536080A JPS5728061A (en) 1980-07-29 1980-07-29 Pyridazinone derivative

Publications (1)

Publication Number Publication Date
JPS5728061A true JPS5728061A (en) 1982-02-15

Family

ID=14405551

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10536080A Pending JPS5728061A (en) 1979-12-05 1980-07-29 Pyridazinone derivative

Country Status (1)

Country Link
JP (1) JPS5728061A (en)

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