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JPS5721360A - Allyl 4-guanidinomethylcyclohexanecarboxylate and its preparation - Google Patents

Allyl 4-guanidinomethylcyclohexanecarboxylate and its preparation

Info

Publication number
JPS5721360A
JPS5721360A JP9666680A JP9666680A JPS5721360A JP S5721360 A JPS5721360 A JP S5721360A JP 9666680 A JP9666680 A JP 9666680A JP 9666680 A JP9666680 A JP 9666680A JP S5721360 A JPS5721360 A JP S5721360A
Authority
JP
Japan
Prior art keywords
formula
compound
acid
preparation
reactive derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9666680A
Other languages
Japanese (ja)
Other versions
JPS6338023B2 (en
Inventor
Mutsumi Muramatsu
Toshio Sato
Yukio Yanagimoto
Tadami Shinnai
Toshio Nakajima
Isao Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Aska Pharmaceutical Co Ltd
Teikoku Chemical Industry Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Teikoku Chemical Industry Co Ltd
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd, Teikoku Chemical Industry Co Ltd, Teikoku Hormone Manufacturing Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP9666680A priority Critical patent/JPS5721360A/en
Publication of JPS5721360A publication Critical patent/JPS5721360A/en
Publication of JPS6338023B2 publication Critical patent/JPS6338023B2/ja
Granted legal-status Critical Current

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  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compounds of formula I [R is -(CH2)nCOOR' (n is 0, 1; R' is H, phenyl, benzyl, alkyl)] and their acid adducts.
EXAMPLE: Trans-4-Guanidinomethylcyclohexanecarboxylic 2'-phenoxycarbonylphenyl ester hydrochloride.
USE: Proteast inhibitor: they strongly inhibit the hydrolysis of proteins caused by a protease such as tripsin, chymotripsin, thrombin, kallikrein or urokinase.
PREPARATION: The reaction of a compound of formula II or its reactive derivative with a compound of formula III affords the titled compound of formula I. The reactive derivative of the compound of formula II is, e.g., its acid chloride, acid bromide or acid anhydride. DMF, DMA or pyridine is used as a reaction solvent.
COPYRIGHT: (C)1982,JPO&Japio
JP9666680A 1980-07-14 1980-07-14 Allyl 4-guanidinomethylcyclohexanecarboxylate and its preparation Granted JPS5721360A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9666680A JPS5721360A (en) 1980-07-14 1980-07-14 Allyl 4-guanidinomethylcyclohexanecarboxylate and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9666680A JPS5721360A (en) 1980-07-14 1980-07-14 Allyl 4-guanidinomethylcyclohexanecarboxylate and its preparation

Publications (2)

Publication Number Publication Date
JPS5721360A true JPS5721360A (en) 1982-02-04
JPS6338023B2 JPS6338023B2 (en) 1988-07-28

Family

ID=14171130

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9666680A Granted JPS5721360A (en) 1980-07-14 1980-07-14 Allyl 4-guanidinomethylcyclohexanecarboxylate and its preparation

Country Status (1)

Country Link
JP (1) JPS5721360A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL.OF MEDICINAL.CHEMISTRY=1972 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0585130A3 (en) * 1992-08-27 1994-06-08 Shiseido Co Ltd External preparation for skin containing a depigmentation agent
US5690914A (en) * 1992-08-27 1997-11-25 Shiseido Co., Ltd External preparation for skin
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Also Published As

Publication number Publication date
JPS6338023B2 (en) 1988-07-28

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