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JPS5695153A - Preparation of 3-isopropylamino-2-hydroxypropanol derivative - Google Patents

Preparation of 3-isopropylamino-2-hydroxypropanol derivative

Info

Publication number
JPS5695153A
JPS5695153A JP17155679A JP17155679A JPS5695153A JP S5695153 A JPS5695153 A JP S5695153A JP 17155679 A JP17155679 A JP 17155679A JP 17155679 A JP17155679 A JP 17155679A JP S5695153 A JPS5695153 A JP S5695153A
Authority
JP
Japan
Prior art keywords
compound shown
formula
reacted
give
hydroxypropanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17155679A
Other languages
Japanese (ja)
Other versions
JPS631937B2 (en
Inventor
Noriyoshi Sueda
Haruhiko Kikuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to JP17155679A priority Critical patent/JPS5695153A/en
Publication of JPS5695153A publication Critical patent/JPS5695153A/en
Publication of JPS631937B2 publication Critical patent/JPS631937B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a β-adrenergic neuronal blocking agent safely in high yield, by using 2,3-epoxypropanol-1 and 2,3-dihydropyran as starting materials by seven processes through the conversion of six novel intermediates, etc.
CONSTITUTION: 2,3-Epoxypropanol-1 is reacted with 2,3-dihydropyran, to give a compound shown by the formula I, which is reacted with benzyl-isopropylamine, to give a compound shown by the formula II. The compound shown by the formula II is reacted with a benzyldihalide in the presence of a base to give a reaction product, which is hydrolyzed in acidic conditions, to give a compound shown by the formula III. The compound shown by the formula III is reacted with dicyclohexylcarbodiimide, and reacted with a compound shown by the formula Ar-OH (Ar is 1-naphthyl or 4-indolyl) to form a compound shown by the formula IV, which is hydrolyzed to give the titled compound shown by the formula V. All the reaction intermediates are novel compounds.
COPYRIGHT: (C)1981,JPO&Japio
JP17155679A 1979-12-28 1979-12-28 Preparation of 3-isopropylamino-2-hydroxypropanol derivative Granted JPS5695153A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17155679A JPS5695153A (en) 1979-12-28 1979-12-28 Preparation of 3-isopropylamino-2-hydroxypropanol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17155679A JPS5695153A (en) 1979-12-28 1979-12-28 Preparation of 3-isopropylamino-2-hydroxypropanol derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP62190393A Division JPS6393752A (en) 1987-07-31 1987-07-31 3-isopropylamino-2-hydroxy-1-propanol derivative

Publications (2)

Publication Number Publication Date
JPS5695153A true JPS5695153A (en) 1981-08-01
JPS631937B2 JPS631937B2 (en) 1988-01-14

Family

ID=15925312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17155679A Granted JPS5695153A (en) 1979-12-28 1979-12-28 Preparation of 3-isopropylamino-2-hydroxypropanol derivative

Country Status (1)

Country Link
JP (1) JPS5695153A (en)

Also Published As

Publication number Publication date
JPS631937B2 (en) 1988-01-14

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