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JPS5657753A - Novel glucagon fragment, and its use - Google Patents

Novel glucagon fragment, and its use

Info

Publication number
JPS5657753A
JPS5657753A JP13406179A JP13406179A JPS5657753A JP S5657753 A JPS5657753 A JP S5657753A JP 13406179 A JP13406179 A JP 13406179A JP 13406179 A JP13406179 A JP 13406179A JP S5657753 A JPS5657753 A JP S5657753A
Authority
JP
Japan
Prior art keywords
bonding
formula
hapten
pref
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13406179A
Other languages
Japanese (ja)
Inventor
Nobuaki Nakagawa
Kikuo Kotani
Kunio Ooyama
Ko Morita
Shigeo Kuzuki
Toshiharu Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP13406179A priority Critical patent/JPS5657753A/en
Priority to SE8007074A priority patent/SE8007074L/en
Priority to FR8021924A priority patent/FR2467841A1/en
Priority to GB8033248A priority patent/GB2062644B/en
Priority to NL8005703A priority patent/NL8005703A/en
Priority to DE19803039122 priority patent/DE3039122A1/en
Publication of JPS5657753A publication Critical patent/JPS5657753A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

NEW MATERIAL:A peptide of formula H-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln- Trp-Leu-Met-Asn-Thr-OH.
USE: Hapten. The addition product of the hapten and proteins easily produces an antibody, which easily undergoes immunological reaction with a labelled glucagon used in the determination.
PROCESS: The peptide of formula is prepared by bonding the amino acids or lower peptides corresponding to the above formula in the order given above, and at the final stage of the bonding reaction, eliminating the protecting group of the functional group of the side chain. The bonding is pref. carried out by the azide process, etc. to prevent the racemization at each step of the bonding. The elimination of the protecting group is carried out in one step pref. by the acid decomposition, e.g. with anhydrous hydrogen fluoride.
COPYRIGHT: (C)1981,JPO&Japio
JP13406179A 1979-10-16 1979-10-16 Novel glucagon fragment, and its use Pending JPS5657753A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP13406179A JPS5657753A (en) 1979-10-16 1979-10-16 Novel glucagon fragment, and its use
SE8007074A SE8007074L (en) 1979-10-16 1980-10-09 GLUCAGON FRAGMENT THAN ITS USE
FR8021924A FR2467841A1 (en) 1979-10-16 1980-10-14 GLUCAGON FRAGMENT AND ITS APPLICATION TO THE PREPARATION OF A SPECIFIC ANTIBODY
GB8033248A GB2062644B (en) 1979-10-16 1980-10-15 Glucagon fragment and utility thereof
NL8005703A NL8005703A (en) 1979-10-16 1980-10-16 GLUCAGON FRAGMENT AND ITS APPLICATION.
DE19803039122 DE3039122A1 (en) 1979-10-16 1980-10-16 GLUCAGON FRAGMENT AND ITS USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13406179A JPS5657753A (en) 1979-10-16 1979-10-16 Novel glucagon fragment, and its use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP14873280A Division JPS5681450A (en) 1980-10-23 1980-10-23 Determination method for glucagon

Publications (1)

Publication Number Publication Date
JPS5657753A true JPS5657753A (en) 1981-05-20

Family

ID=15119442

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13406179A Pending JPS5657753A (en) 1979-10-16 1979-10-16 Novel glucagon fragment, and its use

Country Status (6)

Country Link
JP (1) JPS5657753A (en)
DE (1) DE3039122A1 (en)
FR (1) FR2467841A1 (en)
GB (1) GB2062644B (en)
NL (1) NL8005703A (en)
SE (1) SE8007074L (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835157A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Lymphoblastoid interferon having peptide at terminal n and its derivative
JPS5835125A (en) * 1982-03-26 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of human alpha-interferon antibody
JPS5835156A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Fluorescent peptide and determination of human beta-interferon using the same
JPS5835122A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of antigen
JPS5835155A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Peptide at terminal c of human lymphoblastoid interferon and its derivative
JPS5835123A (en) * 1982-03-26 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of human alpha-interferon antibody
JPS5835124A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of antibody
JPS59122446A (en) * 1982-12-28 1984-07-14 Otsuka Pharmaceut Co Ltd Peptide relating to gamma-interferon
JPS60120824A (en) * 1983-08-17 1985-06-28 ザ　ウエルカム　フアウンデ−シヨン　リミテツド Hormonal blend

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK283180A (en) * 1980-07-01 1982-01-02 Novo Industri As POLYPEPTIDES AND DERIVATIVES THEREOF
GB2160312B (en) * 1984-04-13 1987-09-16 South African Inventions Adjuvant for immunisation
DE9319125U1 (en) * 1993-12-13 1994-02-24 Bulldog Beratungs- und Vertriebsgesellschaft mbH, 28857 Syke Connecting element for connecting a wooden component to a second component
WO2019197313A1 (en) 2018-04-09 2019-10-17 Svar Life Science Ab Glucagon Assay

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642763A (en) * 1967-08-19 1972-02-15 Hoechst Ag Protected glucagon and its hydrobromide salts
JPS5424868A (en) * 1977-07-22 1979-02-24 Takeda Chem Ind Ltd Novel glucagon fragment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836308B2 (en) * 1977-02-10 1983-08-08 大塚製薬株式会社 Antibody production method
US4206199A (en) * 1977-07-22 1980-06-03 Takeda Chemical Industries, Ltd. Novel glucagon fragment and its derivatives
JPS5539702A (en) * 1978-08-30 1980-03-19 Takeda Chem Ind Ltd Method of measuring enzyme immunity of pancreas glucagon

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642763A (en) * 1967-08-19 1972-02-15 Hoechst Ag Protected glucagon and its hydrobromide salts
JPS5424868A (en) * 1977-07-22 1979-02-24 Takeda Chem Ind Ltd Novel glucagon fragment

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835124A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of antibody
JPS5835156A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Fluorescent peptide and determination of human beta-interferon using the same
JPS5835122A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of antigen
JPS5835155A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Peptide at terminal c of human lymphoblastoid interferon and its derivative
JPH0160779B2 (en) * 1981-08-24 1989-12-25 Otsuka Pharma Co Ltd
JPH0160037B2 (en) * 1981-08-24 1989-12-20 Otsuka Pharma Co Ltd
JPH0160040B2 (en) * 1981-08-24 1989-12-20 Otsuka Pharma Co Ltd
JPH0160038B2 (en) * 1981-08-24 1989-12-20 Otsuka Pharma Co Ltd
JPS5835157A (en) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd Lymphoblastoid interferon having peptide at terminal n and its derivative
JPS5835125A (en) * 1982-03-26 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of human alpha-interferon antibody
JPS5835123A (en) * 1982-03-26 1983-03-01 Otsuka Pharmaceut Co Ltd Preparation of human alpha-interferon antibody
JPH0224280B2 (en) * 1982-03-26 1990-05-29 Otsuka Pharma Co Ltd
JPH0160780B2 (en) * 1982-03-26 1989-12-25 Otsuka Pharma Co Ltd
JPH0160480B2 (en) * 1982-12-28 1989-12-22 Otsuka Pharma Co Ltd
JPS59122446A (en) * 1982-12-28 1984-07-14 Otsuka Pharmaceut Co Ltd Peptide relating to gamma-interferon
JPS60120824A (en) * 1983-08-17 1985-06-28 ザ　ウエルカム　フアウンデ−シヨン　リミテツド Hormonal blend

Also Published As

Publication number Publication date
FR2467841A1 (en) 1981-04-30
SE8007074L (en) 1981-04-17
FR2467841B1 (en) 1984-10-19
GB2062644B (en) 1983-04-07
NL8005703A (en) 1981-04-22
DE3039122A1 (en) 1981-04-30
GB2062644A (en) 1981-05-28

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