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JPS5645449A - Novel peptide, its pharmaceutically acceptable salt and preparation of the same - Google Patents

Novel peptide, its pharmaceutically acceptable salt and preparation of the same

Info

Publication number
JPS5645449A
JPS5645449A JP10627980A JP10627980A JPS5645449A JP S5645449 A JPS5645449 A JP S5645449A JP 10627980 A JP10627980 A JP 10627980A JP 10627980 A JP10627980 A JP 10627980A JP S5645449 A JPS5645449 A JP S5645449A
Authority
JP
Japan
Prior art keywords
carboxyl
methyl
agent
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10627980A
Other languages
Japanese (ja)
Other versions
JPH0113463B2 (en
Inventor
Yoshio Kuroda
Hideko Iguchi
Masanobu Kosaka
Hatsuo Aoki
Hiroshi Imanaka
Yoshihiko Kitaura
Osamu Nakaguchi
Keiji Henmi
Matsuhiko Araya
Shuichi Takeno
Tatsu Okada
Hirokazu Tanaka
Shinji Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS5645449A publication Critical patent/JPS5645449A/en
Publication of JPH0113463B2 publication Critical patent/JPH0113463B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A peptide (salt) of formula I [R<1> is H or acyl; Rb<1> is H, methyl, etc.; R<2> and R<q> are Hs, carboxyls, formula II (Ra<2> is mono-, di-carboxy lower alkyl, etc.; Rb<2> is H or lower alkyl), etc.; R<p> is H, carboxyl (when one of R<2> and R<q> is H, the other is carboxyl etc.), etc.; R<r> is H or amino-protecting group; m is an integer 1-3; n is an integer 0-2; R<2> is H, protected carboxyl, etc. when R<1> is H, t-butoxycarbonyl, etc. and Rb<1> is methyl, m being 2, n being 1; R<2> is H, (protected) carboxyl, etc. when R<1> is lactoyl, and Rb<1> is methyl, m being 2, n being 1, R<p> and R<q> being carboxyls, R<r> being H, etc.]. EXAMPLE:Propionyl-L-Ala-gamma-D-Glu(alpha-OH)-(L)-meso DAP-(L)-GlyOH. USE:An immune response enhancer, an activator for the reticulo-endothelial system, an interferon producer, a juvenilizing agent, a protecting agent against infection, an antitumor agent, etc. PROCESS:A compound (salt) of formula III is reacted with an esterifying agent.
JP10627980A 1979-07-31 1980-07-31 Novel peptide, its pharmaceutically acceptable salt and preparation of the same Granted JPS5645449A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7926705 1979-07-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP63054435A Division JPS63258488A (en) 1979-07-31 1988-03-08 Novel peptide, its pharmaceutically acceptable salt and production thereof

Publications (2)

Publication Number Publication Date
JPS5645449A true JPS5645449A (en) 1981-04-25
JPH0113463B2 JPH0113463B2 (en) 1989-03-06

Family

ID=10506908

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10627980A Granted JPS5645449A (en) 1979-07-31 1980-07-31 Novel peptide, its pharmaceutically acceptable salt and preparation of the same

Country Status (1)

Country Link
JP (1) JPS5645449A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5645448A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Peptide* its manufacture and composition containing it
JPS5645447A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Tripeptides* their manufacture and composition containing them
JPS5973527A (en) * 1982-09-27 1984-04-25 Fujisawa Pharmaceut Co Ltd Novel growth-promoting agent and antimycoplasmotic drug for animal
JPS59148745A (en) * 1983-02-08 1984-08-25 Fujisawa Pharmaceut Co Ltd Novel acylglutamyl lysine derivative
JPS60104019A (en) * 1983-11-10 1985-06-08 Fujisawa Pharmaceut Co Ltd Drug for viral disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52151731A (en) * 1976-06-14 1977-12-16 Kyowa Hakko Kogyo Co Ltd Tumor-inhibitory composition
JPS52151732A (en) * 1976-06-14 1977-12-16 Kyowa Hakko Kogyo Co Ltd Prophylactic and therapeutic agent against bacterial
JPS5576850A (en) * 1978-10-19 1980-06-10 Anvar Waterrsoluble compounds derived from extract of streptomyces stimulosus*their manufactures and immunologic adjuvant composition
JPS5636440A (en) * 1979-06-29 1981-04-09 Rhone Poulenc Ind Tetrapeptide and pentapeptide* manufacture thereof and composition containing them
JPS5645447A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Tripeptides* their manufacture and composition containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52151731A (en) * 1976-06-14 1977-12-16 Kyowa Hakko Kogyo Co Ltd Tumor-inhibitory composition
JPS52151732A (en) * 1976-06-14 1977-12-16 Kyowa Hakko Kogyo Co Ltd Prophylactic and therapeutic agent against bacterial
JPS5576850A (en) * 1978-10-19 1980-06-10 Anvar Waterrsoluble compounds derived from extract of streptomyces stimulosus*their manufactures and immunologic adjuvant composition
JPS5636440A (en) * 1979-06-29 1981-04-09 Rhone Poulenc Ind Tetrapeptide and pentapeptide* manufacture thereof and composition containing them
JPS5645447A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Tripeptides* their manufacture and composition containing them

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5645448A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Peptide* its manufacture and composition containing it
JPS5645447A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Tripeptides* their manufacture and composition containing them
JPH0159275B2 (en) * 1979-06-29 1989-12-15 Rhone Poulenc Ind
JPH0159277B2 (en) * 1979-06-29 1989-12-15 Rhone Poulenc Ind
JPS5973527A (en) * 1982-09-27 1984-04-25 Fujisawa Pharmaceut Co Ltd Novel growth-promoting agent and antimycoplasmotic drug for animal
JPH0359882B2 (en) * 1982-09-27 1991-09-12 Fujisawa Pharmaceutical Co
JPS59148745A (en) * 1983-02-08 1984-08-25 Fujisawa Pharmaceut Co Ltd Novel acylglutamyl lysine derivative
JPS60104019A (en) * 1983-11-10 1985-06-08 Fujisawa Pharmaceut Co Ltd Drug for viral disease
JPH0219093B2 (en) * 1983-11-10 1990-04-27 Fujisawa Pharmaceutical Co

Also Published As

Publication number Publication date
JPH0113463B2 (en) 1989-03-06

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