JPS5629550A - Novel preparation of 1-aryloxy-3-isopropylaminopropan-2-ol - Google Patents
Novel preparation of 1-aryloxy-3-isopropylaminopropan-2-olInfo
- Publication number
- JPS5629550A JPS5629550A JP10535279A JP10535279A JPS5629550A JP S5629550 A JPS5629550 A JP S5629550A JP 10535279 A JP10535279 A JP 10535279A JP 10535279 A JP10535279 A JP 10535279A JP S5629550 A JPS5629550 A JP S5629550A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- formula
- lower alkyl
- compound
- halogenoaminoalcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound in high yield, by reacting a stable halogenoaminoalcohol derived from an isopropylamine acid addition salt and an epihalohydrin, with a phenolic compound in the presence of alkaline condensation agent, etc.
CONSTITUTION: The compound of formula III is prepared by reacting (A) an addition salt of a halogenoaminoalcohol of formula I (X is Cl, Br, or I, Y is organic monobasic acid or dibasic acid having 1W10C straight or branched chain or substituted or nonsubstituted aromatic or heterocyclic group, or inorganic weak acid such as boric acid) with (B) a phenolic compound of formula ArOH (Ar is 1- naphthyl or 4-indolyl) in the presence of (C) an alkaline condensation agent such as alkali metal hydroxide or a quaternary ammonium hydroxide or quaternary ammonium alcoholate of formula II (R1WR3 are 1W4C lower alkyl; R4 is 1W4C lower alkyl, etc.; Z is 1W3C lower alkyl).
USE: Remedy for cardiopathy such as arrythmia.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10535279A JPS5629550A (en) | 1979-08-18 | 1979-08-18 | Novel preparation of 1-aryloxy-3-isopropylaminopropan-2-ol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10535279A JPS5629550A (en) | 1979-08-18 | 1979-08-18 | Novel preparation of 1-aryloxy-3-isopropylaminopropan-2-ol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5629550A true JPS5629550A (en) | 1981-03-24 |
Family
ID=14405330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10535279A Pending JPS5629550A (en) | 1979-08-18 | 1979-08-18 | Novel preparation of 1-aryloxy-3-isopropylaminopropan-2-ol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5629550A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485258A (en) * | 1981-08-20 | 1984-11-27 | Mitsubishi Chemical Industries Limited | Pharmaceutically active (3-aminopropoxy)bibenzyl derivatives |
| JPS6284443U (en) * | 1985-11-15 | 1987-05-29 | ||
| JPS62231677A (en) * | 1985-12-31 | 1987-10-12 | アナトミア―ラ ブテイック ドユ ド | Apparatus for relaxing ache and contracture using spark discharge controllable in intensity by piezoelectric power source having bipolar electrode directly contacted with skinat one pole and separated therefrom at other pole |
| CN107556203A (en) * | 2016-06-30 | 2018-01-09 | 康普药业股份有限公司 | A kind of preparation method of Propranolol |
-
1979
- 1979-08-18 JP JP10535279A patent/JPS5629550A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485258A (en) * | 1981-08-20 | 1984-11-27 | Mitsubishi Chemical Industries Limited | Pharmaceutically active (3-aminopropoxy)bibenzyl derivatives |
| US4599419A (en) * | 1981-08-20 | 1986-07-08 | Mitsubishi Chemical Industries, Inc. | Pharmaceutically active (3-cyclic aminopropoxy)bibenzyls as inhibitors of platelet aggregation |
| JPS6284443U (en) * | 1985-11-15 | 1987-05-29 | ||
| JPS62231677A (en) * | 1985-12-31 | 1987-10-12 | アナトミア―ラ ブテイック ドユ ド | Apparatus for relaxing ache and contracture using spark discharge controllable in intensity by piezoelectric power source having bipolar electrode directly contacted with skinat one pole and separated therefrom at other pole |
| JPH0369544B2 (en) * | 1985-12-31 | 1991-11-01 | Anatomiaara Buteitsuku Doyu Do | |
| CN107556203A (en) * | 2016-06-30 | 2018-01-09 | 康普药业股份有限公司 | A kind of preparation method of Propranolol |
| CN107556203B (en) * | 2016-06-30 | 2022-05-03 | 康普药业股份有限公司 | Preparation method of propranolol |
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