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JPS559041A - Synthesis of thioketal - Google Patents

Synthesis of thioketal

Info

Publication number
JPS559041A
JPS559041A JP8210678A JP8210678A JPS559041A JP S559041 A JPS559041 A JP S559041A JP 8210678 A JP8210678 A JP 8210678A JP 8210678 A JP8210678 A JP 8210678A JP S559041 A JPS559041 A JP S559041A
Authority
JP
Japan
Prior art keywords
substituted
thioketal
butylphenol
mercapto
mole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8210678A
Other languages
Japanese (ja)
Inventor
Yasuo Hoshiide
Yoshio Hashimoto
Kenichi Suzuki
Takeji Seki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Original Assignee
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical NIKKEN KAGAKU KK
Priority to JP8210678A priority Critical patent/JPS559041A/en
Publication of JPS559041A publication Critical patent/JPS559041A/en
Pending legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound having blood cholesterol depressing activity, economically, by reacting 4-mercapto-2,6-di-t-butylphenol with acetone in the presence of a specific sulfonic acid ester.
CONSTITUTION: A thioketal of formula II is prepared by reacting 4-mercapto-2, 6-di-t-butylphenol (l mole) with acetone (0.5 mole-large excess amount) in the presence of a sulfonic acid ester of formula I (R1 is alkyl, substituted or non-substituted aryl, arylalkyl; R2 is alkyl, substituted or non-substituted arylalikyl) (0.001- 2 moles), usually in an inert solvent, usually at 40-100°C, pref. at 50-80°C.
COPYRIGHT: (C)1980,JPO&Japio
JP8210678A 1978-07-07 1978-07-07 Synthesis of thioketal Pending JPS559041A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8210678A JPS559041A (en) 1978-07-07 1978-07-07 Synthesis of thioketal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8210678A JPS559041A (en) 1978-07-07 1978-07-07 Synthesis of thioketal

Publications (1)

Publication Number Publication Date
JPS559041A true JPS559041A (en) 1980-01-22

Family

ID=13765149

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8210678A Pending JPS559041A (en) 1978-07-07 1978-07-07 Synthesis of thioketal

Country Status (1)

Country Link
JP (1) JPS559041A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560799A (en) * 1984-02-03 1985-12-24 Ciba-Geigy Corporation Tri- and Tetra-(substituted hydroxyphenylthio) alkane and cycloalkane stabilizers and stabilized compositions
US4719237A (en) * 1986-01-28 1988-01-12 Merrell Dow Pharmaceuticals Inc. Cardiac antiarrythmic method employing probucol
US4772363A (en) * 1987-01-14 1988-09-20 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol by electrocatalysis
US5401883A (en) * 1987-01-20 1995-03-28 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol and 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560799A (en) * 1984-02-03 1985-12-24 Ciba-Geigy Corporation Tri- and Tetra-(substituted hydroxyphenylthio) alkane and cycloalkane stabilizers and stabilized compositions
US4719237A (en) * 1986-01-28 1988-01-12 Merrell Dow Pharmaceuticals Inc. Cardiac antiarrythmic method employing probucol
US4772363A (en) * 1987-01-14 1988-09-20 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol by electrocatalysis
US5401883A (en) * 1987-01-20 1995-03-28 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol and 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol)

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