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JPS5572191A - Antibiotic n-desacetyl ps-5 - Google Patents

Antibiotic n-desacetyl ps-5

Info

Publication number
JPS5572191A
JPS5572191A JP14327878A JP14327878A JPS5572191A JP S5572191 A JPS5572191 A JP S5572191A JP 14327878 A JP14327878 A JP 14327878A JP 14327878 A JP14327878 A JP 14327878A JP S5572191 A JPS5572191 A JP S5572191A
Authority
JP
Japan
Prior art keywords
formula
compound
antibiotic
carboxyl
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14327878A
Other languages
Japanese (ja)
Inventor
Kazuhiko Okamura
Shoji Hirata
Yasushi Okumura
Yasuo Fukagawa
Yasutaka Shimauchi
Tomoyuki Ishikura
Kageaki Kono
Riin Jiyosefu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP14327878A priority Critical patent/JPS5572191A/en
Publication of JPS5572191A publication Critical patent/JPS5572191A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:5,6-Trans-N-Desacetyl derivative of antibiotic PS-5 of formula I and a carboxyl-protected derivative of formula II (R1 is carboxyl-protecting group).
USE: Antibacterials and an intermediate for their synthesis, effective against a wide variety of Gram-positive and Gtram-negative bacteria including β-lactam antibiotic- resistant bacteria, particularly staphylococci.
PROCESS: A carboxyl-protecting group, e.g. a lower alkyl group, is introduced into a 5,6-trans antibiotic of formula III to give a compound of formula II, which is then reacted with an iminohalogenating agent, e.g. PCl5, to form a compound of formula V (X is halogen). The resulting compound is reacted with an alcohol to yield a compound of formula VI (R2 is hydrocarbon group), which is treated with a large amount of water. The protecting group is eliminated to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14327878A 1978-11-22 1978-11-22 Antibiotic n-desacetyl ps-5 Pending JPS5572191A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14327878A JPS5572191A (en) 1978-11-22 1978-11-22 Antibiotic n-desacetyl ps-5

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14327878A JPS5572191A (en) 1978-11-22 1978-11-22 Antibiotic n-desacetyl ps-5

Publications (1)

Publication Number Publication Date
JPS5572191A true JPS5572191A (en) 1980-05-30

Family

ID=15335011

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14327878A Pending JPS5572191A (en) 1978-11-22 1978-11-22 Antibiotic n-desacetyl ps-5

Country Status (1)

Country Link
JP (1) JPS5572191A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53127491A (en) * 1977-04-08 1978-11-07 Merck & Co Inc 33*22aminoethylthio**66ethyll77oxoo 11azabicyclo*3*2*0*heptaa22enee22 carboxylate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53127491A (en) * 1977-04-08 1978-11-07 Merck & Co Inc 33*22aminoethylthio**66ethyll77oxoo 11azabicyclo*3*2*0*heptaa22enee22 carboxylate

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