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JPS54128591A - Cephalosporin analog - Google Patents

Cephalosporin analog

Info

Publication number
JPS54128591A
JPS54128591A JP3469678A JP3469678A JPS54128591A JP S54128591 A JPS54128591 A JP S54128591A JP 3469678 A JP3469678 A JP 3469678A JP 3469678 A JP3469678 A JP 3469678A JP S54128591 A JPS54128591 A JP S54128591A
Authority
JP
Japan
Prior art keywords
formula
compound
group
reacted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3469678A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Takehiro Ogasa
Hiromitsu Saito
Yoshihiro Nakamizo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP3469678A priority Critical patent/JPS54128591A/en
Priority to NO790956A priority patent/NO790956L/en
Priority to NO790955A priority patent/NO790955L/en
Priority to SE7902598A priority patent/SE7902598L/en
Priority to SE7902599A priority patent/SE7902599L/en
Priority to ES478919A priority patent/ES478919A1/en
Priority to BE0/194181A priority patent/BE875054A/en
Priority to BE0/194180A priority patent/BE875053A/en
Priority to ES478932A priority patent/ES478932A1/en
Priority to CA324,178A priority patent/CA1133903A/en
Priority to NL7902316A priority patent/NL7902316A/en
Priority to FR7907415A priority patent/FR2420538A1/en
Priority to DK120179A priority patent/DK120179A/en
Priority to NL7902321A priority patent/NL7902321A/en
Priority to CA000324074A priority patent/CA1178956A/en
Priority to DK119979A priority patent/DK119979A/en
Priority to FR7907414A priority patent/FR2420537B1/en
Priority to AU45368/79A priority patent/AU527128B2/en
Priority to US06/023,645 priority patent/US4291164A/en
Priority to AU45367/79A priority patent/AU528675B2/en
Priority to GB7910507A priority patent/GB2017103B/en
Priority to DE2911787A priority patent/DE2911787C2/en
Priority to CH279079A priority patent/CH640855A5/en
Priority to GB7910506A priority patent/GB2017102B/en
Priority to IT21290/79A priority patent/IT1115153B/en
Priority to DE2911786A priority patent/DE2911786C2/en
Priority to IT67623/79A priority patent/IT1165187B/en
Priority to CH278979A priority patent/CH642369A5/en
Priority to AR275946A priority patent/AR226681A1/en
Publication of JPS54128591A publication Critical patent/JPS54128591A/en
Priority to ES486993A priority patent/ES486993A1/en
Priority to ES486996A priority patent/ES486996A1/en
Priority to ES486995A priority patent/ES486995A1/en
Priority to ES486997A priority patent/ES486997A1/en
Priority to ES486994A priority patent/ES486994A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:A compound of formula I: (X is NH2, N3, or phthalimino group; R1 is H, halogen, lower alkoxy group, etc,; R2 is R1, lower alkyl, N3, etc,; R3 is H, alkyl, aryl group, etc.), and its salt.
EXAMPLE: (±)Cis,2-tert-butyloxycarbonyl-7-azido-1-azabicyclo[4,2,0]oct-2-ene- 8-one.
USE: An intermediate for the synthesis of antibacterials capable of giving powerful antibacterials by introducing various acyl groups into the 7-postion.
PROCESS: A compound of formula II: (R21 is H or lower alkyl group) is reacted with a compound of formula III: (R31 is alkyl, aryl group, etc.), and the reaction product is them reacted with an active derivative of the formula X1CH2COOH (X1 is N3 or phthalylimino group) to give a compound of formula IV, which is then reacted with O3, etc., and subjected to the Horner-Wittig reaction to give the objective compound of formula V.
COPYRIGHT: (C)1979,JPO&Japio
JP3469678A 1978-03-20 1978-03-25 Cephalosporin analog Pending JPS54128591A (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
JP3469678A JPS54128591A (en) 1978-03-25 1978-03-25 Cephalosporin analog
NO790956A NO790956L (en) 1978-03-25 1979-03-21 ANALOGICAL PROCEDURES FOR THE PREPARATION OF CEPHALOSPORINE ANALOG OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
NO790955A NO790955L (en) 1978-03-25 1979-03-21 CEPHALOSPORINE ANALOGUE CARBACEFEM COMPOUNDS AND PROCEDURES FOR MANUFACTURE THEREOF
SE7902598A SE7902598L (en) 1978-03-25 1979-03-22 CEPHALOSPORINE ANALOGES
SE7902599A SE7902599L (en) 1978-03-25 1979-03-22 CEPHALOSPIRINFORENINGAR
AU45368/79A AU527128B2 (en) 1978-03-25 1979-03-23 Cephalosporin analogs
BE0/194181A BE875054A (en) 1978-03-25 1979-03-23 COMPOUNDS ANALOGUE TO CEPHALOSPORINS
BE0/194180A BE875053A (en) 1978-03-25 1979-03-23 COMPOUNDS ANALOGUE TO CEPHALOSPORINS
ES478932A ES478932A1 (en) 1978-03-25 1979-03-23 A procedure for the preparation of cefalosporine analogues. (Machine-translation by Google Translate, not legally binding)
CA324,178A CA1133903A (en) 1978-03-25 1979-03-23 Cephalosporin analogs
NL7902316A NL7902316A (en) 1978-03-25 1979-03-23 CEPHALOSPORIN DERIVATIVES.
FR7907415A FR2420538A1 (en) 1978-03-25 1979-03-23 7-ACYLAMINO-1-CARBA-3-CEPHEM-4-CARBOXYLIC ACIDS, AS COMPOUNDS SIMILAR TO CEPHALOSPORIN, AND PROCESS FOR THE PREPARATION
DK120179A DK120179A (en) 1978-03-25 1979-03-23 CEPHALOSPORINE ANALOG AND METHOD OF MANUFACTURE
NL7902321A NL7902321A (en) 1978-03-25 1979-03-23 CEPHALOSPORIN DERIVATIVES.
CA000324074A CA1178956A (en) 1978-03-25 1979-03-23 Cephalosporin analogs
DK119979A DK119979A (en) 1978-03-25 1979-03-23 CEPHALOSPORINE ANALOG AND METHOD OF MANUFACTURE
FR7907414A FR2420537B1 (en) 1978-03-25 1979-03-23 PRODUCTS SIMILAR TO CEPHALOSPORIN AND THEIR PREPARATION PROCESS
ES478919A ES478919A1 (en) 1978-03-25 1979-03-23 A procedure for the production of cefalosporine analogs. (Machine-translation by Google Translate, not legally binding)
US06/023,645 US4291164A (en) 1978-03-20 1979-03-23 Cephalosporin analogs and methods for production thereof
AU45367/79A AU528675B2 (en) 1978-03-25 1979-03-23 Cephalosporin analogs
GB7910507A GB2017103B (en) 1978-03-25 1979-03-26 Cephalosporin analogues
CH278979A CH642369A5 (en) 1978-03-25 1979-03-26 CEPHALOSPORIN ANALOGS.
CH279079A CH640855A5 (en) 1978-03-25 1979-03-26 CEPHALOSPORIN ANALOGS AND METHOD FOR THE PRODUCTION THEREOF.
GB7910506A GB2017102B (en) 1978-03-25 1979-03-26 Cephalosporin analogues
IT21290/79A IT1115153B (en) 1978-03-25 1979-03-26 Cephalosporin analogues and procedure for their preparation
DE2911786A DE2911786C2 (en) 1978-03-25 1979-03-26 Carbacephem derivatives and their uses
IT67623/79A IT1165187B (en) 1978-03-25 1979-03-26 Cephalosporin analogues and procedure for their preparation
DE2911787A DE2911787C2 (en) 1978-03-25 1979-03-26 Carbacephem derivatives and their uses
AR275946A AR226681A1 (en) 1978-03-25 1979-03-26 PROCEDURE FOR PRODUCING ANALOGS OF CEPHALOSPORIN
ES486993A ES486993A1 (en) 1978-03-25 1979-12-17 A procedure for the production of cefalosporine analogs. (Machine-translation by Google Translate, not legally binding)
ES486996A ES486996A1 (en) 1978-03-25 1979-12-17 A procedure for the production of cefalosporine analogs. (Machine-translation by Google Translate, not legally binding)
ES486995A ES486995A1 (en) 1978-03-25 1979-12-17 A procedure for the preparation of a b-lactama (Machine-translation by Google Translate, not legally binding)
ES486997A ES486997A1 (en) 1978-03-25 1979-12-17 A procedure for the production of cefalosporine analogs. (Machine-translation by Google Translate, not legally binding)
ES486994A ES486994A1 (en) 1978-03-25 1979-12-17 A procedure for the production of cefalosporine analogs. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3469678A JPS54128591A (en) 1978-03-25 1978-03-25 Cephalosporin analog

Publications (1)

Publication Number Publication Date
JPS54128591A true JPS54128591A (en) 1979-10-05

Family

ID=12421522

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3469678A Pending JPS54128591A (en) 1978-03-20 1978-03-25 Cephalosporin analog

Country Status (2)

Country Link
JP (1) JPS54128591A (en)
BE (2) BE875053A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5630976A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Optically active cephalosporin analog

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069832D1 (en) * 1979-09-13 1985-01-31 Kyowa Hakko Kogyo Kk Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
EP2360158A1 (en) 2010-02-18 2011-08-24 Almirall, S.A. Pyrazole derivatives as jak inhibitors
UY33213A (en) 2010-02-18 2011-09-30 Almirall Sa PIRAZOL DERIVATIVES AS JAK INHIBITORS
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
TW201705961A (en) 2015-06-11 2017-02-16 阿爾米雷爾有限公司 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5630976A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Optically active cephalosporin analog
JPS6350356B2 (en) * 1979-08-24 1988-10-07 Kyowa Hakko Kogyo Kk

Also Published As

Publication number Publication date
BE875053A (en) 1979-07-16
BE875054A (en) 1979-07-16

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